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Synthetic Biology : Global Markets

  • June 2014
  • -
  • BCC Research
  • -
  • 270 pages

Synthetic biology is an emerging biotechnology discipline with a wide range of applications. This BCC Research report determines the specific applications and forecast global market demand for synthetic biology products through 2018. This analysis provides a quantitative basis and market context for companies to make strategic choices about participation in the synthetic biology industry.Synthetic biology technologies, growth driving forces, market applications, industry structure and competitive dynamics, companies and industry alliances, future market potential, and product sales forecasts for the period 2013 through 2018 are also analyzed.

Use this report to:
- Receive a comprehensive analysis of the emerging synthetic biology industry.
- Receive information on the forces driving synthetic biology market growth.
- Receive an analysis of the synthetic biology industry's structure, competition, and intellectual property landscape.
- Receive information on companies and industry alliances, and key segments of the industry.

Highlights
- The global synthetic biology market reached nearly $2.1 billion in 2012 and $2.7 billion in 2013. This market is expected to grow to $11.8 billion in 2018 with a compound annual growth rate (CAGR) of 34.4% over the five-year period from 2013 to 2018.
- Enabled products, as a segment, reached $2.0 billion in 2013. The segment is projected to grow to nearly $9.8 billion in 2018, a CAGR of 36.7% over the five-year period from 2013 to 2018.
- Core products, as a segment, reached $349.8 million in 2013. The segment is projected to grow to nearly $1.1 billion in 2018, a CAGR of 25.4% over the five-year period from 2013 to 2018.

INTRODUCTION

STUDY GOALS AND OBJECTIVES
BCC Research’s goal for this study is to determine the specific applications and forecast global market demand for synthetic biology products over a five–year period
from 2013 through 2018. Our particular interest is to characterize and quantify the synthetic biology product market potential by product type and end use market
segments. We also analyze the synthetic biology industry structure, competitors and intellectual property landscape. Synthetic biology markets reviewed in this report include Enabling Products, Biologic Components, Integrated Systems and Enabled Products.

Our key objective is to present a comprehensive analysis of the emerging synthetic biology industry, with an emphasis on products and technologies that are commercially
important in the 2013 through 2018 time period. Market segments with rapid growth rates are highlighted, as well as those segments with large market potential. This
analysis provides a quantitative basis and market context for companies to make strategic choices about participation in the synthetic biology industry. The study will be particularly useful to companies supplying synthetic genes and DNA, oligonucleotides, DNA sequencing instruments, bioinformatics, cell culture media,biofuels, specialty chemicals, pharmaceuticals, vaccines, diagnostics, agricultural seeds, pest control systems, microfluidics, and life sciences tools.

REASONS FOR DOING THE STUDY
Synthetic biology is an emerging biotechnology discipline with a wide range of applications. While there is enormous potential for future applications, synthetic
biology has a significant number of near–term commercial opportunities, and the list of new products and applications is continuously growing. Applications include specialty
chemicals, enzymes, synthetic genes and other DNA parts as well as pharmaceuticals, diagnostics, agricultural seeds, vaccines, biofuels, and chassis microorganisms.
It is important for companies in industries impacted by synthetic biology to sort through the many potential applications; to identify near–term commercial
opportunities for product development and competitive strategy. This report provides pertinent information to assist companies in prioritizing product opportunities, and
establishing a solid framework for strategic planning.

Synthetic biology encompasses a range of industries including life science tools, biotechnology, pharmaceuticals, diagnostics, energy, and chemicals. Because of its
wide scope, synthetic biology plays an important role in the future industrial economy. Continuing advances in enabling technologies such as DNA synthesis and sequencing,
specialty media, and bioinformatics, as well as a need for renewable feedstocks, are driving the growth of the synthetic biology market. Developments in these
multidisciplinary fields promise to advance the synthetic biology industry and create unique market opportunities. This report analyzes these trends and their impact on the
future markets for synthetic biology products. Based on these market and technology dynamics, it is especially timely to examine the current and future synthetic biology markets.

CONTRIBUTION OF THE STUDY AND FOR WHOM
We have compiled a study of existing and future synthetic biology products and technologies that will be commercially important in the main end–user segments of life
science research, pharmaceuticals, diagnostics, energy, chemicals, and agriculture. We present markets by end–user segment (R&D, diagnostics and pharmaceuticals,
energy, chemicals, and agriculture) and by product type (enabling products, biologic components, integrated systems, and enabled products). Key market segments are
covered, including synthetic genes, agriculture, biofuels, specialty chemicals, and pharmaceuticals. We analyze synthetic biology technologies, growth driving forces, market applications, industry structure and competitive dynamics, companies and industry alliances, future market potential, and product sales forecasts for the period 2013 through 2018. We project the future use of synthetic biology products in the main end–user segments and by product type.

This report will be of particular interest to companies in the industries of pharmaceuticals, chemicals, enzymes, energy, agriculture, diagnostics, bioinformatics, biotechnology, and nanobiotechnology, as well as suppliers of genomics tools, DNA synthesis and DNA sequencing products. It will also be of high interest to professionals
within governments and regulatory agencies to understand the scope and pace of synthetic biology technologies as they reach the market.

SCOPE AND FORMAT
The study scope includes core synthetic biology products (synthetic genes, other DNA parts, chassis organisms, synthetic cells), enabling technologies (DNA sequencing,
oligonucleotides, specialty media, bioinformatics), and enabled technologies (biofuels, specialty chemicals, diagnostics, pharmaceuticals, agriculture) that are already
commercialized or are forecast to be commercialized within the next five years. We analyze key synthetic biology technologies and products to determine present and
future market status, and forecasted growth from 2013 through 2018. We also discuss strategic alliances, industry structures, competitive dynamics, patents, and market
driving forces.

BCC Research examines the synthetic biology industry by market segment, including suppliers of synthetic genes, enzymes, pharmaceuticals, biofuels, and specialty
chemicals. The role of key strategic alliances from 2012 through 2014 is discussed. Emerging markets including synthetic genes, synthetic biology–enabled drugs and
vaccines, chassis organisms, as well as metabolically–engineered factories for producing synthetic fuels and specialty chemicals are analyzed and more than 130
companies in these fields are highlighted.

METHODOLOGY
BCC Research surveys key users and producers in each of the end–user market segments and technology fields that will be commercially important during the next
five years. Discussions with industry thought leaders, as well as secondary market research was performed. Based on our analysis, we project the future applications of synthetic biology technologies in the major end–user market segments and by technology type, and forecast sales revenues for 2013 through 2018.

Table Of Contents

Synthetic Biology : Global Markets
TABLE OF CONTENTS

CHAPTER 1 INTRODUCTION 2
STUDY GOALS AND OBJECTIVES 2
REASONS FOR DOING THE STUDY 2
CONTRIBUTION OF THE STUDY AND FOR WHOM 3
SCOPE AND FORMAT 3
TABLE A SCOPE OF REPORT 4
METHODOLOGY 4
INFORMATION SOURCES 4
RELATED BCC RESEARCH REPORTS 5
ANALYST'S CREDENTIALS 5
BCC RESEARCH WEBSITE 5
DISCLAIMER 6

CHAPTER 2 SUMMARY 8
SUMMARY TABLE GLOBAL VALUE OF SYNTHETIC BIOLOGY MARKET, BY PRODUCT
TYPE, THROUGH 2018 ($ MILLIONS) 8
SUMMARY FIGURE GLOBAL VALUE OF SYNTHETIC BIOLOGY MARKET, BY PRODUCT
TYPE, 2012-2018 ($ MILLIONS) 8

CHAPTER 3 OVERVIEW 12
SYNTHETIC BIOLOGY TECHNOLOGIES COVERED IN THIS REPORT 12
TABLE 1 SCOPE OF THIS REPORT 12
FIGURE 1 SYNTHETIC BIOLOGY VALUE-ADDED CHAIN 12
WHAT IS SYNTHETIC BIOLOGY? 13
DEVELOPMENT STAGE OF SYNTHETIC BIOLOGY 14
FIGURE 2 FROM THE NATURAL TO THE ARTIFICIAL 14
TABLE 2 SYNTHETIC BIOLOGY PARADIGM 15
FORCES DRIVING SYNTHETIC BIOLOGY MARKET GROWTH 15
TABLE 3 SYNTHETIC BIOLOGY GROWTH: DRIVING FORCES 16
GLOBAL MARKETS FOR SYNTHETIC BIOLOGY PRODUCTS 17
TABLE 4 GLOBAL VALUE OF SYNTHETIC BIOLOGY MARKET, BY END-USER
INDUSTRY, THROUGH 2018 ($ MILLIONS) 17
LIFE CYCLE STATUS OF PRODUCTS AND TECHNOLOGIES 18
TABLE 5 SYNTHETIC BIOLOGY PRODUCTS AND TECHNOLOGY LIFE CYCLE STAGE 18
THE SYNTHETIC BIOLOGY INDUSTRY 19
TABLE 6 SYNTHETIC BIOLOGY COMPETITORS BY MARKET FOCUS 19

CHAPTER 4 SYNTHETIC BIOLOGY TECHNOLOGIES 22
INTRODUCTION 22
SYNTHETIC BIOLOGY DEFINED 22
TABLE 7 SYNTHETIC BIOLOGY DEFINITIONS 22
HISTORY OF SYNTHETIC BIOLOGY 23
TABLE 8 SYNTHETIC BIOLOGY HISTORY 23
PARADIGM SHIFT IN BIOLOGY 25
TABLE 9 PARADIGM SHIFT CAUSED BY SYNTHETIC BIOLOGY 26
SUMMARY FIGURE 26
TABLE 10 GENETIC ENGINEERING AND SYNTHETIC BIOLOGY COMPARED 27
FIGURE 3 SCALE OF SYNTHETIC BIOLOGY 28
SYNTHETIC BIOLOGY TECHNOLOGY OVERVIEW 29
TABLE 11 SYNTHETIC BIOLOGY APPLICATIONS BY TECHNOLOGY 29
ENABLING TECHNOLOGIES 30
TABLE 12 IMPORTANCE OF ENABLING TECHNOLOGIES 30
DNA SYNTHESIS AND SEQUENCING COST TRENDS 31
TABLE 13 COSTS TO SEQUENCE AND SYNTHESIZE A HUMAN GENOME, 2001-2014 31
DNA SYNTHESIS TECHNOLOGIES 32
FIGURE 4 SCHEMATIC OF GENE SYNTHESIS TECHNOLOGIES 32
TABLE 14 COMPARISONS OF GENE SYNTHESIS TECHNOLOGIES 34
PCR-based approaches 34
Solid-phase Approaches 35
MICROFLUIDIC TECHNOLOGIES 35
TABLE 15 IMPORTANCE OF MICROFLUIDICS TECHNOLOGIES IN SYNTHETIC
BIOLOGY 35
DNA Microarrays - Oligos Synthesis 36
TABLE 16 MICROARRAY TYPES 36
TABLE 17 DNA MICROARRAY PLATFORM FEATURES 37
TABLE 18 DNA MICROARRAY PLATFORM COMPARISON FOR MAJOR
MANUFACTURERS 38
FIGURE 5 MICROARRAYS IN GENE SYNTHESIS 40
DNA SEQUENCING TECHNOLOGIES 41
TABLE 19 WORKFLOW COMPARISON OF SELECTED NEXT-GENERATION DNA
SEQUENCING PLATFORMS 41
TABLE 20 BIOCHIP CONTENT IN NEXT-GENERATION SEQUENCING MACHINES 42
BIOINFORMATICS TECHNOLOGIES 43
TABLE 21 SYNTHETIC BIOLOGY BIOINFORMATICS TECHNOLOGIES 44
BIOLOGICAL COMPONENTS AND INTEGRATED SYSTEMS TECHNOLOGIES 44
TABLE 22 NUCLEIC ACIDS, GENES, AND GENOMES 45
SYNTHETIC GENES 45
TABLE 23 SYNTHETIC GENES AS MOLECULAR BIOLOGY TOOL 46
TABLE 24 SYNTHETIC GENES VERSUS PCR CLONING 47
BIOBRICK PARTS 49
TABLE 25 BIOBRICK PARTS 49
FIGURE 6 ROLE OF PROMOTERS AND REPORTERS IN SYNTHETIC BIOLOGY
SYSTEMS 50
MINIMAL GENOMES AND CHASSIS ORGANISMS 51
TABLE 26 ATTRIBUTES OF A MINIMAL GENOME 51
Case Study: Minimal E. coli Genome 52
Role of Directed Evolution in Designing Biologic Parts 53
ENABLED TECHNOLOGIES 53
TABLE 27 ENABLED TECHNOLOGIES: EXISTING AND NEAR-TERM APPLICATIONS 54
PATHWAY ENGINEERING 54
FIGURE 7 HOW SYNTHETIC BIOLOGY CREATES ENABLED PRODUCTS 54
TABLE 28 METABOLIC ENGINEERING FOR ARTEMISINIC ACID 56
SYNTHETIC MICROBIAL CONSOTRIA 57
TABLE 29 APPLICATIONS FOR SYNTHETIC MICROBIAL CONSORTIA 57
RESEARCH AND DEVELOPMENT APPLICATIONS 58
TABLE 30 RESEARCH and DEVELOPMENT APPLICATIONS FOR SYNTHETIC BIOLOGY
PRODUCTS 59
BIOFUELS TECHNOLOGIES 59
OVERVIEW 59
TABLE 31 ADVANCED BIOFUELS TYPES 60
FIRST AND SECOND GENERATION BIOFUEL TECHNOLOGIES 61
TABLE 32 FIRST AND SECOND GENERATION BIOFUELS COMPARED 61
CROP FEEDSTOCKS 62
TABLE 33 ENERGY BALANCE OF SELECTED FIRST-GENERATION BIOFUEL
FEEDSTOCKS 62
CELLULOSIC FEEDSTOCKS 63
TABLE 34 APPROXIMATE COMPOSITION OF CELLULOSIC BIOMASS (%) 63
TABLE 35 SYNTHETIC BIOLOGY STRATEGIES FOR CONVERTING CELLULOSIC
BIOMASS INTO ETHANOL 64
TABLE 36 BIOMASS ECONOMICS, 2013 64
ALGAE FEEDSTOCKS 64
TABLE 37 BIODIESEL YIELD OF SELECTED CROPS 64
CARBON DIOXIDE FEEDSTOCKS 66
BIOFUEL END PRODUCTS 66
TABLE 38 EFFICIENCY OF VARIOUS FUELS (%) 66
Cellulosic Ethanol 67
FIGURE 8 CELLULOSIC ETHANOL PRODUCTION SCHEMATIC 67
Biodiesel 68
TABLE 39 IODINE NUMBER OF VARIOUS OILS 69
Other Biofuels 69
Role of Genetic Engineering and Synthetic Biology in Biofuels 69
TABLE 40 CONTRIBUTION OF SYNTHETIC BIOLOGY TO BIOFUELS 70

CHAPTER 5 SYNTHETIC BIOLOGY APPLICATIONS 72
INTRODUCTION 72
ENABLING TECHNOLOGIES APPLICATIONS 72
TABLE 41 SYNTHETIC BIOLOGY PRODUCTS IMPACTED BY ENABLING
TECHNOLOGIES 72
BIOLOGIC COMPONENTS AND INTEGRATED SYSTEMS APPLICATIONS 73
TABLE 42 BIOLOGICAL COMPONENTS AND INTEGRATED SYSTEMS NEAR-TERM
APPLICATIONS 73
SYNTHETIC GENE APPLICATIONS 73
TABLE 43 SYNTHETIC GENES NEAR-TERM APPLICATIONS 74
BIOBRICK PARTS APPLICATIONS 76
INTEGRATED SYSTEMS APPLICATIONS 77
TABLE 44 E. COLI AS A CHASSIS ORGANISM 77
Synthetic Cells and Tissues 78
Cellular Factories 79
ENABLED PRODUCTS APPLICATIONS 79
PHARMACEUTICALS 79
TABLE 45 SYNTHETIC BIOLOGY-ENABLED DRUG CLASSES 80
TABLE 46 DRUG DISCOVERY AND DEVELOPMENT APPLICATIONS FOR SYNTHETIC
BIOLOGY PRODUCTS 80
TABLE 47 SYNTHETIC BIOLOGY-ENABLED PHARMACEUTICAL APPLICATIONS 81
DIAGNOSTICS 87
TABLE 48 SYNTHETIC BIOLOGY-ENABLED DIAGNOSTICS APPLICATIONS 87
BIOFUELS 88
TABLE 49 SYNTHETIC BIOLOGY-ENABLED BIOFUELS APPLICATIONS 88
TABLE 50 GROWTH STATUS OF SPECIALTY VERSUS DROP-IN BIOFUELS 89
CHEMICALS 89
TABLE 51 SYNTHETIC BIOLOGY-ENABLED CHEMICALS APPLICATIONS 90
ENGINEERED PLANTS AND INSECTS 91
TABLE 52 SYNTHETIC BIOLOGY-ENABLED ENGINEERED PLANTS AND INSECTS
APPLICATIONS 91
PRODUCTION PROCESSES 92
TABLE 53 SYNTHETIC BIOLOGY-ENABLED PRODUCTION PROCESSES APPLICATIONS 92

CHAPTER 6 SYNTHETIC BIOLOGY INDUSTRY 94
INDUSTRIAL BIOTECHNOLOGY VALUE CHAIN 94
FIGURE 9 INDUSTRIAL BIOTECHNOLOGY VALUE CHAIN WITH SYNTHETIC BIOLOGY
LEVERAGE POINTS 94
INDUSTRY STRUCTURAL FORCES 95
TABLE 54 SYNTHETIC BIOLOGY INDUSTRY STRUCTURAL FORCES 95
PRODUCTS AND TECHNOLOGY LIFE CYCLE 97
TABLE 55 SYNTHETIC BIOLOGY PRODUCTS AND TECHNOLOGY LIFE CYCLE STAGE 97
GENE SYNTHESIS INDUSTRY 98
GENE SYNTHESIS WORKFLOW 98
TABLE 56 GENE SYNTHESIS WORKFLOW 98
GENE SYNTHESIS COMPETITORS 100
TABLE 57 SYNTHETIC GENE COMPANY ESTIMATED 2013 MARKET SHARES 100
TABLE 58 SYNTHETIC GENE KEY COMPETITOR STRATEGIES 102
GENE SYNTHESIS VALUE CHAIN 104
SYNTHETIC GENE MARKET SEGMENTS 105
Standardized Segment 105
Value Added Segment 105
TABLE 59 GENE SYNTHESIS MARKET FACTORS OF DIFFERENTIATION 106
BIOFUEL INDUSTRY 107
COMPETITIVE DIFFERENTIATION 107
FEEDSTOCKS 107
TABLE 60 BIOFUELS: FEEDSTOCKS, PRODUCTION AND PRODUCTS 108
TABLE 61 BIOFUELS FEEDSTOCKS: RELATIVE SUPPLY VOLUME AND COSTS 109
TABLE 62 BIODIESEL YIELD OF SELECTED CROPS 110
BIOFUEL COMPETITOR STRATEGIES 111
TABLE 63 SYNTHETIC BIOLOGY BIOFUELS COMPANY STRATEGIES 111
TABLE 64 UNITED STATES SYNTHETIC BIOLOGY-ENABLED BIOFUELS CAPACITY,
2013-2018 116
CHEMICALS INDUSTRY 117
TABLE 65 SYNTHETIC BIOLOGY-ENABLED CHEMICALS APPLICATIONS 117
TABLE 66 VALUE-ADDED IN SELECTED END MARKETS ($/TON) 118
ENZYMES INDUSTRY 119
TABLE 67 SYNTHETIC BIOLOGY ENZYME COMPANY KEY ALLIANCES 120
PHARMACEUTICALS INDUSTRY 121
TABLE 68 PHARMACEUTICAL COMPANY SYNTHETIC BIOLOGY STRATEGIES 121
ACQUISITIONS AND STRATEGIC ALLIANCES 123
TABLE 69 SYNTHETIC BIOLOGY INDUSTRY ACQUISITIONS, 2012 THROUGH 2014 123
TABLE 70 STRATEGIC ALLIANCES, 2012-2014 125

CHAPTER 7 SYNTHETIC BIOLOGY MARKETS 134
INDUSTRY GROWTH DRIVING FORCES 134
TABLE 71 SYNTHETIC BIOLOGY GROWTH DRIVING FORCES 134
SYNTHETIC BIOLOGY MARKETS BY END USER INDUSTRY 136
TABLE 72 GLOBAL VALUE OF SYNTHETIC BIOLOGY MARKET, BY END USER
INDUSTRY, THROUGH 2018 ($ MILLIONS) 136
RandD MARKET 137
TABLE 73 GLOBAL VALUE OF R andD MARKET, BY PRODUCT TYPE, THROUGH 2018 ($
MILLIONS) 137
DIAGNOSTICS AND PHARMACEUTICALS MARKET 138
TABLE 74 GLOBAL VALUE OF DIAGNOSTICS AND PHARMACEUTIALS MARKET BY
PRODUCT TYPE, THROUGH 2018 ($ MILLIONS) 139
CHEMICALS MARKET 140
TABLE 75 GLOBAL VALUE OF CHEMICALS MARKET, BY PRODUCT TYPE, THROUGH
2018 ($ MILLIONS) 141
ENERGY MARKET 141
TABLE 76 GLOBAL VALUE OF ENERGY MARKET, BY PRODUCT TYPE, THROUGH
2018 ($ MILLIONS) 142
AGRICULTURE MARKET 142
TABLE 77 GLOBAL VALUE OF AGRICULTURE MARKET, BY PRODUCT TYPE,
THROUGH 2018 ($ MILLIONS) 143
SYNTHETIC BIOLOGY MARKETS BY PRODUCT TYPE 143
TABLE 78 GLOBAL VALUE OF SYNTHETIC BIOLOGY MARKET, BY PRODUCT TYPE,
THROUGH 2018 ($ MILLIONS) 143
ENABLING PRODUCTS MARKETS 145
TABLE 79 GLOBAL VALUE OF SYNTHETIC BIOLOGY ENABLING PRODUCTS, BY TYPE,
THROUGH 2018 ($ MILLIONS) 145
TABLE 80 GLOBAL VALUE OF SYNTHETIC BIOLOGY ENABLING PRODUCTS, BY
INDUSTRY, THROUGH 2018 ($ MILLIONS) 146
BIOLOGIC COMPONENTS MARKET 147
TABLE 81 GLOBAL VALUE OF BIOLOGIC COMPONENTS MARKET, BY TYPE,
THROUGH 2018 ($ MILLIONS) 147
Synthetic Gene Standardized Market Segment 148
Synthetic Gene Value added Market Segment 148
TABLE 82 GLOBAL VALUE OF BIOLOGIC COMPONENTS MARKET, BY INDUSTRY,
THROUGH 2018 ($ MILLIONS) 149
INTEGRATED SYSTEMS MARKET 150
TABLE 83 GLOBAL VALUE OF INTEGRATED SYSTEMS MARKET, BY TYPE, THROUGH
2018 ($ MILLIONS) 150
Integrated Systems Market by Industry 151
TABLE 84 GLOBAL VALUE OF INTEGRATED SYSTEMS MARKET, BY INDUSTRY,
THROUGH 2018 ($ MILLIONS) 151
ENABLED PRODUCTS MARKET 152
Sources of Competitive Advantage 152
TABLE 85 BIODIESEL FUEL PERFORMANCE COMPARISON 152
TABLE 86 ARTEMISININ DRUG PRODUCTION COMPARISON 153
TABLE 87 GLOBAL VALUE OF SYNTHETIC BIOLOGY ENABLED PRODUCTS MARKET,
BY INDUSTRY, THROUGH 2018 ($ MILLIONS) 153
DIAGNOSTICS AND PHARMACEUTICALS MARKET 154
TABLE 88 GLOBAL VALUE OF ENABLED DIAGNOSTIC AND PHARMACEUTICALS
MARKET, BY INDUSTRY, THROUGH 2018 ($ MILLIONS) 155
TABLE 89 GLOBAL VALUE OF SYNTHETIC BIOLOGY-ENABLED DIAGNOSTICS
MARKET, BY INDICATION, THROUGH 2018 ($ MILLIONS) 155
TABLE 90 FOOD DIAGNOSTICS INDUSTRY, 2013 ($ MILLIONS/%) 157
TABLE 91 GLOBAL VALUE OF ENABLED PHARMACEUTICALS MARKET, BY DRUG
CLASS, THROUGH 2018 ($ MILLIONS) 158
CHEMICALS MARKET 160
TABLE 92 FACTORS FOR SYNTHETIC BIOLOGY-BASED CHEMICAL PROCESSES 160
TABLE 93 GLOBAL VALUE OF ENABLED CHEMICALS MARKET, BY PRODUCT TYPE,
THROUGH 2018 ($ MILLIONS) 161
BIOFUELS MARKET 166
TABLE 94 ADVANCED BIOFUEL GROWTH DRIVING FACTORS 166
TABLE 95 KEY SYNTHETIC BIOLOGY-BIOFUEL ALLIANCES: 2012 THROUGH 2014 168
TABLE 96 GLOBAL VALUE OF SYNTHETIC BIOLOGY-ENABLED BIOFUELS MARKET,
BY FUEL TYPE, THROUGH 2018 ($ MILLIONS) 168
AGRICULTURE MARKET 170
TABLE 97 GLOBAL VALUE OF AGRICULTURE MARKET, BY APPLICATION, THROUGH
2018 ($ MILLIONS) 170
SYNTHETIC BIOLOGY MARKET BY REGION 172
ALL SYNTHETIC BIOLOGY PRODUCTS BY REGION 172
TABLE 98 GLOBAL VALUE OF SYNTHETIC BIOLOGY MARKET, BY REGION, THROUGH
2018 ($ MILLIONS) 172
ENABLING PRODUCTS MARKET BY GEOGRAPHY 173
TABLE 99 GLOBAL VALUE OF ENABLING PRODUCTS MARKET, BY REGION,
THROUGH 2018 ($ MILLIONS) 174
CORE PRODUCTS BY REGION 174
TABLE 100 GLOBAL VALUE OF CORE PRODUCTS MARKET, BY REGION, THROUGH
2018 ($ MILLIONS) 174
ENABLED PRODUCTS BY REGION 175
TABLE 101 GLOBAL VALUE OF ENABLED PRODUCTS MARKET, BY REGION,
THROUGH 2018 ($ MILLIONS) 175

CHAPTER 8 PATENTS 179
INTRODUCTION 179
TABLE 102 SYNTHETIC BIOLOGY PATENT SCOPE 179
FOUNDATIONAL PATENTS 180
TABLE 103 SYNTHETIC BIOLOGY FOUNDATIONAL PATENTS 181
SYNTHETIC BIOLOGY INDUSTRY PATENT ANALYSIS 182
TABLE 104 SYNTHETIC BIOLOGY PATENT LANDSCAPE, BY COMPANY 183
TABLE 105 PATENT DESCRIPTION BY COMPANY 184
PATENT STRATEGY OF SELECTED COMPANIES 186
METABOLIX 186
DUPONT 187
GENEART (LIFE TECHNOLOGIES) 187

CHAPTER 9 COMPANY PROFILES 190
ACTIVE MOTIF 190
AGILIS BIOTHERAPEUTICS LLC 190
AGRIVIDA 191
TABLE 106 AGRIVIDA TECHNICAL APPROACH 191
ALGENICS 192
ALGENOL BIOFUELS 192
ALGENUITY 193
ALLYLIX 193
AMBRX INC. 194
AMYRIS INC. 194
TABLE 107 AMYRIS BIODIESEL ADVANTAGES 195
ARZEDA CORP. 196
ATG BIOSYNTHETICS GMBH 196
AUTODESK INC. 197
AVIDBIOTICS CORP. 197
BACTERIAL ROBOTICS LLC 198
BASF AG 199
BAYER AG 200
BETA RENEWABLES 201
BIOAMBER INC. 201
BIO BASIC CANADA INC. 202
BIOMAX INFORMATICS AG 202
BIONEER CORP. 203
BIONEXUS INC. 203
BIOSEARCH TECHNOLOGIES INC. 204
BIO SandT INC. 204
BLUE MARBLE BIOMATERIALS 204
BRITISH PETROLEUM 205
CALYSTA ENERGY INC. 206
CAMBRIAN GENOMICS INC. 206
CARIBOU BIOSCIENCES INC. 207
CELLECTIS SA 207
CHEVRON CORP. 208
COBALT TECHNOLOGIES 209
CODEXIS INC. 209
DEMURIS LTD. 210
DESKTOP GENETICS LTD. 211
DNA2.0 211
DOW CHEMICAL COMPANY 212
E.I DU PONT DE NEMOURS AND COMPANY 213
DYADIC INTERNATIONAL INC. 214
ENBIOTIX INC. 215
ENEVOLV INC. 215
EPOCH LIFE SCIENCE INC. 216
EUROFINS MWG OPERON 216
EVOLUTIONARY SOLUTIONS INC. 217
EVOLVA SA 218
TABLE 108 EVOLVA'S GENETIC CHEMISTRY PLATFORM 218
TABLE 109 EVOLVA PRODUCT STATUS 219
EVOZYM BIOLOGICS INC. 220
EXXONMOBILE CORP. 220
GEN9 INC. 221
TABLE 110 LINEAR GENE SYNTHESIS PRODUCTS 222
GENABLER LTD. 222
GENEMED SYNTHESIS INC. 223
GENEWORKS PTY. LTD. 223
GENEORACLE INC. 223
GENOMATICA 224
GENOME COMPILER CORP. 225
GENSCRIPT USA INC. 225
GEVO INC. 226
GINKGO BIOWORKS 226
GLOBAL BIOENERGIES 227
GLOWING PLANT 228
GLYCOS BIOTECHNOLOGIES INC. 228
GOODYEAR TIRE and RUBBER CO. 228
GREEN BIOLOGICS LTD. 229
HELIX NANOTECHNOLOGIES INC. 229
ILLUMINA INC. 230
INGENZA LTD. 230
INTEGRATED DNA TECHNOLOGIES INC. 231
INTERNATIONAL BUSINESS MACHINES 231
INTREXON CORP. 232
TABLE 111 INTREXON ULTRAVECTOR PARTS INVENTORY EXAMPLES 232
TABLE 112 INTREXON CHANNEL PARTNER STATUS 233
IOGEN CORP. 234
JOULE UNLIMITED 234
LABGENIUS LTD. 235
LANZATECH 235
LATTICE AUTOMATION 236
LC SCIENCES 236
LS9 INC. 237
LYGOS INC. 237
MASCOMA CORP. 238
MERCK and CO. 238
METABOLIX INC. 239
TABLE 113 MIREL COMPETITORS IN BIOPLASTICS 240
MICHELIN SA 240
MICROSOFT CORP. 240
MODULAR GENETICS 241
MORPH BIOINFORMATICS 241
MORPHOSYS AG 242
MYRIANT CORP. 243
NEW ENGLAND BIOLABS 243
NOVACTA BIOSYSTEMS LTD. 244
NOVARTIS AG 245
TABLE 114 STEPS TO PRODUCE SYNTHETIC BIOLOGICALLY-DERIVED FLU SEED 246
NOVOZYMES A/S 246
OMEGA BIO-TEK INC. 248
OPX BIOTECHNOLOGIES INC. 248
ORAGENICS 249
ORIGENE TECHNOLOGIES INC. 250
OXITEC LTD. 251
PACIFIC BIOSCIENCES OF CALIFORNIA INC. 252
PARETO BIOTECHNOLOGIES INC. 253
PEACCEL INC. 253
PFIZER 254
PHYLOGIA LIMITED 255
PHYTOWELT GREEN TECHNOLOGIES GMBH 255
PROKARIUM LTD. 256
PROTERRO INC. 256
QTEROS INC. 257
RADIANT GENOMICS INC. 257
REFACTORED MATERIALS 257
RENNOVIA INC. 258
ROOSTERBIO INC. 258
ROYAL DSM N.V. 258
SAMPLE6 259
SANGAMO BIOSCIENCES INC. 260
TABLE 115 SANGAMO KEY STRATEGIC ALLIANCES 261
SANOFI AVENTIS 263
SAPPHIRE ENERGY 264
SCARAB GENOMICS LLC. 264
SEA6 ENERGY LTD. 265
SGI-DNA INC. 265
SHANGHAI GENERAY BIOTECH CO. LTD. 266
SHANGHAI SHINEGENE MOLECULAR BIO-TECHNOLOGIES INC. 266
SIGMA ALDRICH CORP. 266
SILICOLIFE LDA. 267
SOLAZYME INC. 267
TABLE 116 FACTORS AFFECTING BIOFUELS ADOPTION 269
SOLIGENIX INC. 269
SUTRO BIOPHARMA INC. 270
SYNPROMICS LTD. 270
SYNTHACE LTD. 271
SYNTHETIC BIOLOGICS INC. 271
SYNTHETIC GENOMICS INC. 272
SYNTHORX INC. 273
TAURIGA SCIENCES INC. 274
TESELAGEN BIOTECHNOLOGY INC. 274
THERMO FISHER SCIENTIFIC INC. 275
TRITON ALGAE INNOVATIONS LTD. 276
UNIVERSAL BIOMINING 276
VERDEZYNE INC. 276
VG LIFE SCIENCES INC. 278
ZIOPHARM ONCOLOGY INC. 278


LIST OF TABLES

TABLE A SCOPE OF REPORT 4
SUMMARY TABLE GLOBAL VALUE OF SYNTHETIC BIOLOGY MARKET, BY PRODUCT
TYPE, THROUGH 2018 ($ MILLIONS) 8
TABLE 1 SCOPE OF THIS REPORT 12
TABLE 2 SYNTHETIC BIOLOGY PARADIGM 15
TABLE 3 SYNTHETIC BIOLOGY GROWTH: DRIVING FORCES 16
TABLE 4 GLOBAL VALUE OF SYNTHETIC BIOLOGY MARKET, BY END-USER INDUSTRY,
THROUGH 2018 ($ MILLIONS) 17
TABLE 5 SYNTHETIC BIOLOGY PRODUCTS AND TECHNOLOGY LIFE CYCLE STAGE 18
TABLE 6 SYNTHETIC BIOLOGY COMPETITORS BY MARKET FOCUS 19
TABLE 7 SYNTHETIC BIOLOGY DEFINITIONS 22
TABLE 8 SYNTHETIC BIOLOGY HISTORY 23
TABLE 9 PARADIGM SHIFT CAUSED BY SYNTHETIC BIOLOGY 26
TABLE 10 GENETIC ENGINEERING AND SYNTHETIC BIOLOGY COMPARED 27
TABLE 11 SYNTHETIC BIOLOGY APPLICATIONS BY TECHNOLOGY 29
TABLE 12 IMPORTANCE OF ENABLING TECHNOLOGIES 30
TABLE 13 COSTS TO SEQUENCE AND SYNTHESIZE A HUMAN GENOME, 2001-2014 31
TABLE 14 COMPARISONS OF GENE SYNTHESIS TECHNOLOGIES 34
TABLE 15 IMPORTANCE OF MICROFLUIDICS TECHNOLOGIES IN SYNTHETIC BIOLOGY 35
TABLE 16 MICROARRAY TYPES 36
TABLE 17 DNA MICROARRAY PLATFORM FEATURES 37
TABLE 18 DNA MICROARRAY PLATFORM COMPARISON FOR MAJOR MANUFACTURERS 38
TABLE 19 WORKFLOW COMPARISON OF SELECTED NEXT-GENERATION DNA
SEQUENCING PLATFORMS 41
TABLE 20 BIOCHIP CONTENT IN NEXT-GENERATION SEQUENCING MACHINES 42
TABLE 21 SYNTHETIC BIOLOGY BIOINFORMATICS TECHNOLOGIES 44
TABLE 22 NUCLEIC ACIDS, GENES, AND GENOMES 45
TABLE 23 SYNTHETIC GENES AS MOLECULAR BIOLOGY TOOL 46
TABLE 24 SYNTHETIC GENES VERSUS PCR CLONING 47
TABLE 25 BIOBRICK PARTS 49
TABLE 26 ATTRIBUTES OF A MINIMAL GENOME 51
TABLE 27 ENABLED TECHNOLOGIES: EXISTING AND NEAR-TERM APPLICATIONS 54
TABLE 28 METABOLIC ENGINEERING FOR ARTEMISINIC ACID 56
TABLE 29 APPLICATIONS FOR SYNTHETIC MICROBIAL CONSORTIA 57
TABLE 30 RESEARCH and DEVELOPMENT APPLICATIONS FOR SYNTHETIC BIOLOGY
PRODUCTS 59
TABLE 31 ADVANCED BIOFUELS TYPES 60
TABLE 32 FIRST AND SECOND GENERATION BIOFUELS COMPARED 61
TABLE 33 ENERGY BALANCE OF SELECTED FIRST-GENERATION BIOFUEL
FEEDSTOCKS 62
TABLE 34 APPROXIMATE COMPOSITION OF CELLULOSIC BIOMASS (%) 63
TABLE 35 SYNTHETIC BIOLOGY STRATEGIES FOR CONVERTING CELLULOSIC
BIOMASS INTO ETHANOL 64
TABLE 36 BIOMASS ECONOMICS, 2013 64
TABLE 37 BIODIESEL YIELD OF SELECTED CROPS 64
TABLE 38 EFFICIENCY OF VARIOUS FUELS (%) 66
TABLE 39 IODINE NUMBER OF VARIOUS OILS 69
TABLE 40 CONTRIBUTION OF SYNTHETIC BIOLOGY TO BIOFUELS 70
TABLE 41 SYNTHETIC BIOLOGY PRODUCTS IMPACTED BY ENABLING TECHNOLOGIES 72
TABLE 42 BIOLOGICAL COMPONENTS AND INTEGRATED SYSTEMS NEAR-TERM
APPLICATIONS 73
TABLE 43 SYNTHETIC GENES NEAR-TERM APPLICATIONS 74
TABLE 44 E. COLI AS A CHASSIS ORGANISM 77
TABLE 45 SYNTHETIC BIOLOGY-ENABLED DRUG CLASSES 80
TABLE 46 DRUG DISCOVERY AND DEVELOPMENT APPLICATIONS FOR SYNTHETIC
BIOLOGY PRODUCTS 80
TABLE 47 SYNTHETIC BIOLOGY-ENABLED PHARMACEUTICAL APPLICATIONS 81
TABLE 48 SYNTHETIC BIOLOGY-ENABLED DIAGNOSTICS APPLICATIONS 87
TABLE 49 SYNTHETIC BIOLOGY-ENABLED BIOFUELS APPLICATIONS 88
TABLE 50 GROWTH STATUS OF SPECIALTY VERSUS DROP-IN BIOFUELS 89
TABLE 51 SYNTHETIC BIOLOGY-ENABLED CHEMICALS APPLICATIONS 90
TABLE 52 SYNTHETIC BIOLOGY-ENABLED ENGINEERED PLANTS AND INSECTS
APPLICATIONS 91
TABLE 53 SYNTHETIC BIOLOGY-ENABLED PRODUCTION PROCESSES APPLICATIONS 92
TABLE 54 SYNTHETIC BIOLOGY INDUSTRY STRUCTURAL FORCES 95
TABLE 55 SYNTHETIC BIOLOGY PRODUCTS AND TECHNOLOGY LIFE CYCLE STAGE 97
TABLE 56 GENE SYNTHESIS WORKFLOW 98
TABLE 57 SYNTHETIC GENE COMPANY ESTIMATED 2013 MARKET SHARES 100
TABLE 58 SYNTHETIC GENE KEY COMPETITOR STRATEGIES 102
TABLE 59 GENE SYNTHESIS MARKET FACTORS OF DIFFERENTIATION 106
TABLE 60 BIOFUELS: FEEDSTOCKS, PRODUCTION AND PRODUCTS 108
TABLE 61 BIOFUELS FEEDSTOCKS: RELATIVE SUPPLY VOLUME AND COSTS 109
TABLE 62 BIODIESEL YIELD OF SELECTED CROPS 110
TABLE 63 SYNTHETIC BIOLOGY BIOFUELS COMPANY STRATEGIES 111
TABLE 64 UNITED STATES SYNTHETIC BIOLOGY-ENABLED BIOFUELS CAPACITY,
2013-2018 116
TABLE 65 SYNTHETIC BIOLOGY-ENABLED CHEMICALS APPLICATIONS 117
TABLE 66 VALUE-ADDED IN SELECTED END MARKETS ($/TON) 118
TABLE 67 SYNTHETIC BIOLOGY ENZYME COMPANY KEY ALLIANCES 120
TABLE 68 PHARMACEUTICAL COMPANY SYNTHETIC BIOLOGY STRATEGIES 121
TABLE 69 SYNTHETIC BIOLOGY INDUSTRY ACQUISITIONS, 2012 THROUGH 2014 123
TABLE 70 STRATEGIC ALLIANCES, 2012-2014 125
TABLE 71 SYNTHETIC BIOLOGY GROWTH DRIVING FORCES 134
TABLE 72 GLOBAL VALUE OF SYNTHETIC BIOLOGY MARKET, BY END USER INDUSTRY,
THROUGH 2018 ($ MILLIONS) 136
TABLE 73 GLOBAL VALUE OF R andD MARKET, BY PRODUCT TYPE, THROUGH 2018 ($
MILLIONS) 137
TABLE 74 GLOBAL VALUE OF DIAGNOSTICS AND PHARMACEUTIALS MARKET BY
PRODUCT TYPE, THROUGH 2018 ($ MILLIONS) 139
TABLE 75 GLOBAL VALUE OF CHEMICALS MARKET, BY PRODUCT TYPE, THROUGH
2018 ($ MILLIONS) 141
TABLE 76 GLOBAL VALUE OF ENERGY MARKET, BY PRODUCT TYPE, THROUGH 2018
($ MILLIONS) 142
TABLE 77 GLOBAL VALUE OF AGRICULTURE MARKET, BY PRODUCT TYPE, THROUGH
2018 ($ MILLIONS) 143
TABLE 78 GLOBAL VALUE OF SYNTHETIC BIOLOGY MARKET, BY PRODUCT TYPE,
THROUGH 2018 ($ MILLIONS) 143
TABLE 79 GLOBAL VALUE OF SYNTHETIC BIOLOGY ENABLING PRODUCTS, BY TYPE,
THROUGH 2018 ($ MILLIONS) 145
TABLE 80 GLOBAL VALUE OF SYNTHETIC BIOLOGY ENABLING PRODUCTS, BY
INDUSTRY, THROUGH 2018 ($ MILLIONS) 146
TABLE 81 GLOBAL VALUE OF BIOLOGIC COMPONENTS MARKET, BY TYPE, THROUGH
2018 ($ MILLIONS) 147
TABLE 82 GLOBAL VALUE OF BIOLOGIC COMPONENTS MARKET, BY INDUSTRY,
THROUGH 2018 ($ MILLIONS) 149
TABLE 83 GLOBAL VALUE OF INTEGRATED SYSTEMS MARKET, BY TYPE, THROUGH
2018 ($ MILLIONS) 150
TABLE 84 GLOBAL VALUE OF INTEGRATED SYSTEMS MARKET, BY INDUSTRY,
THROUGH 2018 ($ MILLIONS) 151
TABLE 85 BIODIESEL FUEL PERFORMANCE COMPARISON 152
TABLE 86 ARTEMISININ DRUG PRODUCTION COMPARISON 153
TABLE 87 GLOBAL VALUE OF SYNTHETIC BIOLOGY ENABLED PRODUCTS MARKET, BY
INDUSTRY, THROUGH 2018 ($ MILLIONS) 153
TABLE 88 GLOBAL VALUE OF ENABLED DIAGNOSTIC AND PHARMACEUTICALS
MARKET, BY INDUSTRY, THROUGH 2018 ($ MILLIONS) 155
TABLE 89 GLOBAL VALUE OF SYNTHETIC BIOLOGY-ENABLED DIAGNOSTICS MARKET,
BY INDICATION, THROUGH 2018 ($ MILLIONS) 155
TABLE 90 FOOD DIAGNOSTICS INDUSTRY, 2013 ($ MILLIONS/%) 157
TABLE 91 GLOBAL VALUE OF ENABLED PHARMACEUTICALS MARKET, BY DRUG
CLASS, THROUGH 2018 ($ MILLIONS) 158
TABLE 92 FACTORS FOR SYNTHETIC BIOLOGY-BASED CHEMICAL PROCESSES 160
TABLE 93 GLOBAL VALUE OF ENABLED CHEMICALS MARKET, BY PRODUCT TYPE,
THROUGH 2018 ($ MILLIONS) 161
TABLE 94 ADVANCED BIOFUEL GROWTH DRIVING FACTORS 166
TABLE 95 KEY SYNTHETIC BIOLOGY-BIOFUEL ALLIANCES: 2012 THROUGH 2014 168
TABLE 96 GLOBAL VALUE OF SYNTHETIC BIOLOGY-ENABLED BIOFUELS MARKET, BY
FUEL TYPE, THROUGH 2018 ($ MILLIONS) 168
TABLE 97 GLOBAL VALUE OF AGRICULTURE MARKET, BY APPLICATION, THROUGH
2018 ($ MILLIONS) 170
TABLE 98 GLOBAL VALUE OF SYNTHETIC BIOLOGY MARKET, BY REGION, THROUGH
2018 ($ MILLIONS) 172
TABLE 99 GLOBAL VALUE OF ENABLING PRODUCTS MARKET, BY REGION, THROUGH
2018 ($ MILLIONS) 174
TABLE 100 GLOBAL VALUE OF CORE PRODUCTS MARKET, BY REGION, THROUGH
2018 ($ MILLIONS) 174
TABLE 101 GLOBAL VALUE OF ENABLED PRODUCTS MARKET, BY REGION, THROUGH
2018 ($ MILLIONS) 175
TABLE 102 SYNTHETIC BIOLOGY PATENT SCOPE 179
TABLE 103 SYNTHETIC BIOLOGY FOUNDATIONAL PATENTS 181
TABLE 104 SYNTHETIC BIOLOGY PATENT LANDSCAPE, BY COMPANY 183
TABLE 105 PATENT DESCRIPTION BY COMPANY 184
TABLE 106 AGRIVIDA TECHNICAL APPROACH 191
TABLE 107 AMYRIS BIODIESEL ADVANTAGES 195
TABLE 108 EVOLVA'S GENETIC CHEMISTRY PLATFORM 218
TABLE 109 EVOLVA PRODUCT STATUS 219
TABLE 110 LINEAR GENE SYNTHESIS PRODUCTS 222
TABLE 111 INTREXON ULTRAVECTOR PARTS INVENTORY EXAMPLES 232
TABLE 112 INTREXON CHANNEL PARTNER STATUS 233
TABLE 113 MIREL COMPETITORS IN BIOPLASTICS 240
TABLE 114 STEPS TO PRODUCE SYNTHETIC BIOLOGICALLY-DERIVED FLU SEED 246
TABLE 115 SANGAMO KEY STRATEGIC ALLIANCES 261
TABLE 116 FACTORS AFFECTING BIOFUELS ADOPTION 269


LIST OF FIGURES

SUMMARY FIGURE GLOBAL VALUE OF SYNTHETIC BIOLOGY MARKET, BY PRODUCT
TYPE, 2012-2018 ($ MILLIONS) 8
FIGURE 1 SYNTHETIC BIOLOGY VALUE-ADDED CHAIN 12
FIGURE 2 FROM THE NATURAL TO THE ARTIFICIAL 14
SUMMARY FIGURE 26
FIGURE 3 SCALE OF SYNTHETIC BIOLOGY 28
FIGURE 4 SCHEMATIC OF GENE SYNTHESIS TECHNOLOGIES 32
FIGURE 5 MICROARRAYS IN GENE SYNTHESIS 40
FIGURE 6 ROLE OF PROMOTERS AND REPORTERS IN SYNTHETIC BIOLOGY SYSTEMS 50
FIGURE 7 HOW SYNTHETIC BIOLOGY CREATES ENABLED PRODUCTS 54
FIGURE 8 CELLULOSIC ETHANOL PRODUCTION SCHEMATIC 67
FIGURE 9 INDUSTRIAL BIOTECHNOLOGY VALUE CHAIN WITH SYNTHETIC BIOLOGY
LEVERAGE POINTS 94

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