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Sleep Aids: Technologies and Global Markets

  • October 2016
  • -
  • BCC Research
  • -
  • 253 pages

Use this report to:
- Analyze the current market dynamics and evaluate the effect of strategic factors such as technology-driven change and industry consolidation of sleep aids and technologies.
- Review the main products in each sector and plan a product entry strategy in line with the strengths and weaknesses of the competition.
- Assess products, trends, new developments and compensation issues.
- Discuss the major stakeholders in each of the regional markets and explain the global drivers, current trends, challenges and regional dynamics of the market.

Highlights
- The global market for sleep aids and technologies is expected to reach $84.9 billion by 2021 from $66.3 billion in 2016, rising at a compound annual growth rate (CAGR) of 5.1% from 2016 through 2021.
- The mattresses and pillows market is the largest segment, expected to grow from $31.5 billion in 2016 to $35.9 billion in 2021 at a CAGR of 2.6% for the period 2016-2021.
- The global market for sleep apnea devices is expected to grow from $17.8 billion in 2016 to $27.5 billion in 2021 at a CAGR of 9.1% for the period 2016-2021.

Introduction & Scope


INTRODUCTION


STUDY GOALS AND OBJECTIVES
Insomnia, sleep apnea, restless leg syndrome (RLS), bruxism, narcolepsy and sleepwalking are all serious sleep disorders that bring about negative health consequences. Often undiagnosed and thus not treated, sleep disorders can not only take a toll on personal health but can also have adverse effects on personal relationships and reduce worker productivity. In examining the steep increase in a variety of sleep disorders, this report will analyze the causes and available treatments for sleep disorder sufferers. This report describes in detail the overall market for sleep aids and then gives an account of the segment revenues.

REASONS FOR DOING THE STUDY
This BCC Research study provides the latest highlights in the exciting area of sleep disorders. Research on the working of the human brain in relation to sleep is a fairly
new area, with many new and novel theories. The discovery of new mechanisms and chemicals in the brain has provided expanding avenues for research and development
(R&D) of products that are likely to alter the course of sleep disorders or modify the outcome. This study analyzes the current therapies for sleep disorders and new therapies that are in the pipeline. The report provides the latest information on leading products and R&D initiatives in the area of sleep disorders. Moreover, the report gives an extensive review of the leading firms in this market sector.

SCOPE OF STUDY
This report primarily focuses on the following sleep disorders:
- Insomnia.
- Sleep apnea.
- RLS.
- Bruxism.
- Narcolepsy.
- Sleepwalking.

The report discusses products, trends, new developments and compensation issues that are currently affecting or are likely to affect the market soon. Analyses are
provided for each of the key companies in the major and minor market segments. The sleep aids and diagnostic centers discussed in this report include:
- Medications.
- Prescriptions.
- Over-the-counter (OTC).
- Herbal remedies.
- Sleep laboratories.
- Sleep apnea devices.
- Mattresses and pillows.

All markets are further broken down into specific types of products that are discussed in detail, measuring current and potential market size, identifying current and potential
market drivers, detailing the markets from 2015, 2016 and 2021 and assessing the competitors in the market and their respective shares in various market segments.




METHODOLOGY AND INFORMATION SOURCES
Both primary and secondary research methodologies were used in preparing this research report. The information and analysis presented are based on extensive first-hand interviews with primary executives, product managers, clinical specialists and doctors involved in the sleep disorder arena. Background information was obtained from various government, business, medical journal and trade magazine sources. Interviews were also used to confirm and/or adjust market size and market share estimates, as well as to formulate market projections. The segments in this report on mattresses, medications and devices measure retail sales based on industry and trade association reporting, in conjunction with a spectrum of perspectives from industry contacts and personal sources, buttressed by the author’s views and expert analysis.

Table Of Contents

Sleep Aids: Technologies and Global Markets
CHAPTER 1 INTRODUCTION 2
STUDY GOALS AND OBJECTIVES 2
REASONS FOR DOING THE STUDY 2
SCOPE OF STUDY 2
METHODOLOGY AND INFORMATION SOURCES 3
ANALYST'S CREDENTIALS 3
RELATED BCC RESEARCH REPORTS 3
BCC RESEARCH WEBSITE 3
DISCLAIMER 4
CHAPTER 2 EXECUTIVE SUMMARY 6
SUMMARY TABLE A GLOBAL MARKET FOR SLEEP AIDS AND TECHNOLOGIES, BY
TYPE, THROUGH 2021 ($ BILLIONS) 9
SUMMARY FIGURE A GLOBAL MARKET FOR SLEEP AIDS AND TECHNOLOGIES, BY
TYPE, 2015-2021 ($ BILLIONS) 9
SUMMARY TABLE B GLOBAL MARKET SHARES FOR SLEEP AIDS AND
TECHNOLOGIES, BY REGION, THROUGH 2021 (%) 10
SUMMARY FIGURE B GLOBAL MARKET SHARES OF SLEEP AIDS AND
TECHNOLOGIES, BY REGION, 2015-2021 (%) 10
CHAPTER 3 NORMAL SLEEP AND SLEEP DISORDERS: AN OVERVIEW 12
TABLE 1 NORMAL SLEEP ARCHITECTURE 12
PHYSIOLOGY OF NORMAL SLEEP 12
FIGURE 1 PROGRESSION OF SLEEP STATES ACROSS A SINGLE NIGHT IN YOUNG
ADULTS 13
NREM AND REM SLEEP CYCLES 13
Four Stages of NREM Sleep 13
FIGURE 2 CHARACTERISTIC EEG ACTIVITY OF EACH OF THE FOUR STAGES OF
NREM SLEEP 14
Stage 1 Sleep 14
Stage 2 Sleep 14
Stages 3 and 4 Sleep 15
REM Sleep 15
PHYSIOLOGY DURING SLEEP 15
TABLE 2 PHYSIOLOGICAL CHANGES DURING NREM AND REM SLEEP 16
NEWLY RECOMMENDED SLEEP DURATIONS 17
TABLE 3 NEWLY RECOMMENDED SLEEP DURATIONS BY THE NATIONAL SLEEP
FOUNDATION (HOURS) 17
CURRENT RESEARCH FOCUSED ON SLEEP 17
NIH Funding for Research on Sleep 18
FIGURE 3 NIH SLEEP RESEARCH FUNDING, 2010-2017 ($ MILLIONS) 18
NICHD's Focus on Sleep Research 19
TABLE 4 NICHD-FUNDED RESEARCH ON SLEEP 19
SELECTED CLINICAL TRIALS ON SLEEP 20
TABLE 5 SELECTED CLINICAL TRIALS ON SLEEP 20
CHAPTER 4 SLEEP DISORDERS AND TREATMENT OPTIONS: AN OVERVIEW 22
CLASSIFICATION OF SLEEP DISORDERS 22
INSOMNIA 24
Acute Insomnia (Short-time Insomnia) 25
Diagnosis of Acute Insomnia 25
Chronic Insomnia 25
Causes of Chronic Insomnia 25
Evaluation of Chronic Insomnia 26
TABLE 6 MANDATORY ASSESSMENT OF CHRONIC INSOMNIA 26
Physician's Examinations for the Diagnosis 27
TABLE 7 PHYSICIANS' EXAMINATIONS FOR THE DIAGNOSIS OF CHRONIC INSOMNIA 27
Treatment for Insomnia 28
Behavioral Therapy 28
Stimulus Control Therapy 28
Sleep Restriction Therapy 28
Relaxation Therapy 29
Cognitive Therapy 29
Paradoxical Intension Therapy 29
Sleep Hygiene Education Method 29
Behavioral Intervention Therapy 29
Drug Therapy for Insomnia 30
First-line Drug Therapy 30
Benzodiazepines 30
Non-Benzodiazepines 30
Second-line Drug Therapy 31
Alternative Drugs 31
TABLE 8 DRUGS FOR INSOMNIA, BY TYPE (MG) 31
OBSTRUCTIVE SLEEP APNEA 32
Symptoms and Risk Factors of OSA 32
Diagnosis of OSA 33
Treatment of OSA 33
NARCOLEPSY 34
Symptoms of Narcolepsy 34
Treatments for Narcolepsy 35
TABLE 9 PRESCRIPTION DRUGS USED FOR NARCOLEPSY 36
RESTLESS LEG SYNDROME 36
Causes and Symptoms of RLS 36
Treatments for RLS 37
CHAPTER 5 SLEEP DISORDERS: DISEASE MANAGEMENT 39
TYPES OF SLEEP TESTING 39
HOME SLEEP TESTING 39
Process of HST 40
TABLE 10 HOME SLEEP TESTS VS. FACILITY-BASED TESTING 40
Disadvantages of HST 40
Contents of an HST Test Kit 41
U.S. Market Share of HST Sleep Disorder Tests 41
FIGURE 4 U.S. MARKET SHARE FOR HST AND IN-CLINIC TESTS (%) 41
IN-LAB SLEEP STUDY 42
Percent of Sleep Disorder Types Diagnosed in Sleep Centers 42
FIGURE 5 TYPES OF SLEEP DISORDERS DIAGNOSED IN SLEEP CENTERS (%) 42
POLYSOMNOGRAM TESTS 43
Disorders Diagnosed by PSG 44
Equipment Used for Diagnosis of PSG 44
Results of a PSG 45
MULTIPLE SLEEP LATENCY TEST 45
PROCEDURE OF A MAINTENANCE OF WAKEFULNESS TEST 46
ACTIGRAPHY TESTS 46
CONTINUOUS POSITIVE AIRWAY PRESSURE 47
CPAP TITRATION STUDY 47
Process of CPAP Titration Study 47
SURGERY FOR SLEEP DISORDERS 48
SLEEP-AID SUPPLEMENTS AND ALTERNATIVE THERAPIES 48
MELATONIN SUPPLEMENTS 48
HERBAL INSOMNIA MEDICATIONS THAT TARGET GABA SYSTEMS 48
TABLE 11 HERBAL SLEEP MEDICINES 49
Piper Methysticum 49
Zizyphus Jujuba 50
Valeriana Officinalis 50
Hypericum Montbrettii 50
Pinus Massoniana 51
Scutellaria Baicalensis 51
Atractylodes Macrocephala 51
Ipomoea Tyrianthina 51
Temstroemia Lineate 52
Rhus Parviflora 52
Dimocarpus Longan 52
Crassocephalum Bauchiense 52
Chrysanthemum Morifolium 53
Dorstenia Arifolia 53
Magnolia Officinalis 53
Glycyrrhiza Glabra 54
Ecklonia Cava 54
Melissa Officinalis 54
HOMEOPATHIC MEDICINES FOR SLEEP DISORDERS 54
Coffea Cruda 54
Nux Vomica 55
Pulsatilla 55
Sulphur 55
Phosphorus 56
Passiflora Incarnata 56
Kali Phosphoricum 56
AROMA THERAPY FOR SLEEP DISORDERS 56
Lavender 56
Vetiver 57
Roman Chamomile 57
Bergamot 57
Sandalwood 57
Marjoram 57
Clary Sage 58
Frankincense 58
CHAPTER 6 SLEEP-AID MEDICATIONS: AN OVERVIEW 60
NEW SLEEP DRUGS (NON-BENZODIAZEPINES) 60
TABLE 12 EXAMPLES OF NEW SLEEPING PILLS 60
EFFECTIVENESS OF NEW SLEEPING PILLS 61
TABLE 13 COMPARATIVE EFFICACIES OF SELECTED NEW SLEEPING PILLS (MINUTES) 61
SIDE EFFECTS OF NEW SLEEP DRUGS 61
PRIOR SLEEP DRUGS 62
TABLE 14 EXAMPLES OF BENZODIAZEPINES 62
DIFFERENCES BETWEEN THE NEW AND PRIOR SLEEPING PILLS 63
TABLE 15 PHARMACOKINETIC PROFILES OF COMMON BENZODIAZEPINES AND
THEIR APPROVED INDICATIONS 64
MOST FREQUENTLY PRESCRIBED INSOMNIA DRUGS 64
TABLE 16 MOST FREQUENTLY PRESCRIBED INSOMNIA DRUGS 64
Zaleplon (Sonata) 65
Zolpidem (Ambien) 65
Triazolam (Halcion) 66
Ramelteon (Rozerem) 66
Eszopiclone (Lunesta) 67
Suvorexant (Belsomra) 67
OTHER POPULAR SLEEP DRUGS 67
Butisol Sodium (Butabarbital Sodium Tablets) 67
Doxepine Hydrochloride 67
Estazolam 68
Flurazepam 68
Horizant (Gabapentin Enacarbil) 68
Melatonin Pyridoxine HCL 68
Nuvigil (Armodafinil) 68
Provigil (Modafinil) 69
Quazepam 69
Restoril (Temazepam) 69
Rozerem (Ramelteon) 69
Seconal Sodium 70
Somnote (Chloral Hydrate) 70
Xyrem (Sodium Oxybate) 70
Zolpimist (Zolpidem Tartrate) 70
PRICES OF INSOMNIA DRUGS 71
TABLE 17 PRICES OF SLEEPING PILLS ($) 71
MECHANISM OF ACTION FOR DIFFERENT SLEEP DRUGS 71
TABLE 18 SELECTED SLEEP DRUGS, MECHANISM OF ACTION, DURATION OF
EFFECT AND ADDICTION RISK 72
PRECAUTIONS FOR USING SLEEPING PILLS 73
TREATING INSOMNIA WITHOUT PRESCRIPTION DRUGS 74
OTC Sleeping Pills 74
TABLE 19 OTC INSOMNIA DRUGS 74
OTC Natural Sleep Aids 75
TABLE 20 EXAMPLES OF OTC NATURAL SLEEP AIDS 76
CHAPTER 7 SLEEP-AID DEVICES: AN OVERVIEW 80
HOME SLEEP TESTING DEVICES 80
POPULAR HST DEVICES IN THE MARKET 81
Sleep Profiler 81
MediByte Jr 81
SleepView 81
TABLE 21 COMPARISON OF SLEEP PROFILER, MEDIBYTE JR AND SLEEP VIEW 82
Somte 82
Apnea Risk Evaluation System 82
Zmachine Insight 83
TABLE 22 COMPARISON OF SOMTE, ARES AND ZMACHINE INSIGHT 83
WatchPAT 83
Embletta MPR 84
Nomad 84
TABLE 23 COMPARISON OF WATCHPAT, EMBLETTA MPR AND NOMAD 84
LX Sleep/OxyHolter 84
AccuSom 85
NOX-T3 85
TABLE 24 COMPARISON OF LX SLEEP/OXYHOLTER, ACCUSOM AND NOX-T3 85
Alice NightOne 85
ApneaLink 86
ARES 86
TABLE 25 COMPARISON OF ALICE NIGHTONE, APNEALINK AIR AND ARES 86
BWMini HST/PSG 86
SomnoTouch RESP 87
TABLE 26 COMPARISON OF BWMINI HST/PSG AND SOMNOTOUCH RESP 87
PSG DEVICES FOR IN-LAB SLEEP STUDIES 87
Easy II Amplifier 87
Easy Ambulatory with Easy III Software 88
TABLE 27 COMPARISON OF EASY III AMPLIFIER WITH EASY III SOFTWARE AND EASY
AMBULATORY WITH EASY III SOFTWARE 88
SomnoStar z4 Sleep System 89
Sapphire PSG 89
TABLE 28 COMPARISON OF SOMNOSTAR SOFTWARE WITH Z4 AMPLIFIER AND
SAPHIRE PSG AMPLIFIER WITH CRYSTAL PSG SOFTWARE 90
Grael HD-PSG 91
Somte PSG 91
TABLE 29 COMPARISON OF GRAEL HD-PSG AMPLIFIER WITH PROFUSION PSG 3
SOFTWARE AND SOMTE PSG SYSTEM WITH PROFUSION PSG 3 SOFTWARE 92
Sandman Elite 93
PSG-1100 Sleep System 93
TABLE 30 COMPARISON OF SANDMAN SOFTWARE WITH S4500/MDRIVE AMPLIFIER
AND PSG-1100 SLEEP SYSTEM 94
Alice 6 LDxN 95
Galaxy PSG Diagnostic Platform 95
TABLE 31 COMPARISON OF ALICE 6 LDXW WITH SLEEPWARE G3 AND GALAXY PSG
DIAGNOSTIC PLATFORM WITH JUPITER AMPLIFIER 95
Sleepvirtual BWIII 97
SomnoScreen Plus PSG 97
TABLE 32 COMPARISON OF SLEEPVIRTUAL BWIII AND SOMNOSCREEN PLUS PSG
WITH DOMINO SOFTWARE 97
ACTIGRAPHS 98
GT9X ActiGraph Link 99
Night Shift 99
TABLE 33 COMPARISON OF ACTIGRAPH LINK AND NIGHT SHIFT 99
Micro Motion Logger Watch 100
Motionlogger Watch 100
TABLE 34 COMPARISON OF MICRO MOTION LOGGER WATCH AND MOTIONLOGGER
WATCH 100
MotionWatch8 100
Pro-Diary 101
TABLE 35 COMPARISON OF MOTIONWATCH 8 AND PRO-DIARY 101
Actiwatch Spectrum Pro 101
SomnoWatch 101
TABLE 36 COMPARISON OF ACTIWATCH SPECTRUM PRO AND SOMNOWATCH 101
CPAP MACHINES 102
Top CPAP Machines 102
XT Fit 102
Transcend Travel 103
RESmart 103
60 Series Pro Bluetooth 103
TABLE 37 COMPARISON OF XT FIT CPAP, TRANSCEND TRAVEL, RESMART CPAP
AND 60 SERIES PRO BLUETOOTH 103
SleepStyle 234 CPAP 104
Z1 Travel 105
IntelliPAP Standard Plus 105
Transcend EZEX 105
TABLE 38 COMPARISON OF SLEEPSTYLE HC234, Z1 TRAVEL, INTELLIPAP
STANDARD PLUS AND TRANSCEND EZEX 105
IntelliPAP Standard 106
AirSense 10 106
Curasa 107
AirSense 10 Elite 107
TABLE 39 COMPARISON OF INTELLIPAP STANDARD, AIRSENSE 10, CURASA AND
AIRSENSE 10 ELITE 107
ICON Premo 108
DreamStation Pro 108
DreamStation 108
Luna 109
TABLE 40 COMPARISON OF ICON PROMO, DREAMSTATION PRO, DREAMSTATION
AND LUNA 109
CPAP INTERFACES 110
Ecco Full Face Mask 110
Nonny 110
myTAP PAP Nasal Pillow Mask 111
Advantage Series Full Face Mask 111
SleepWeaver Advance Nasal 111
Simplus Full Face 111
V2 Full Face 111
Quest Homecare Full 111
Aloha Nasal 112
Amara View 112
TABLE 41 COMPARISON OF TEN POPULAR CPAP MASKS 112
ORAL APPLIANCES 113
Apnea Guard 113
myTAP 113
TAP 113
ApneaRx 114
Adjustable TheraSnore 114
Oasys 114
aveoTSD 114
Silent Nite 114
MPow Rx 115
Moses 115
Myerson EMA 115
Narval CC 115
Adjustable Dorsal 115
Full Breath Solution 116
Lamberg Sleep Well 116
ZQuiet Pro-Plus 116
SomnoDent Flex 116
SomnoDent G2 116
Standard SUAD 117
SUE 2G 117
TABLE 42 SELECTED FEATURES OF 20 ORAL APPLIANCES 117
WHITE NOISE AND SOUND MACHINES FOR SLEEP 118
Popular Sound Machines 118
HoMedics Deep Sleep 118
LectroFan 118
Sound + Sleep 119
Sound Oasis S-650-01 119
Sound Oasis BST-100 119
Marpac Dohm 119
Sound Oasis S-550-05 120
HoMedics Sound Spa 120
CONSUMER SLEEP MONITORS 120
Misfit Beddit 120
Withings Aura 120
LifeTrack Brite R450 121
ResMed S+ 121
SleepRate 121
Omvana 121
Philips HF3520 Wake-Up Light 121
Talking Alarm Clock and Night Light 122
Fitbit 122
Cloud B Tranquil Turtle 122
REM Dreamer 122
Zero Sleep Manager Pro 122
TABLE 43 FEATURES OF COMMON CONSUMER SLEEP MONITORS 123
MATTRESSES AND PILLOWS 123
Types of Mattresses 123
Innerspring Mattresses 123
TABLE 44 COMPARISON OF SELECTED INNERSPRING MATTRESSES 124
Memory Foam Mattresses 124
TABLE 45 COMPARISON OF SELECTED MEMORY FOAM MATTRESSES 124
Inflatable Air Mattresses 125
TABLE 46 COMPARISON OF SELECTED AIR MATTRESSES 125
Gel Mattresses 125
Popular Mattresses 125
SureTemp 126
Ultimate Dreams 126
Dynasty Cool Breeze 126
Stanberry 126
Beauty Rest 126
TABLE 47 COMPARISON OF SELECTED MATTRESSES 127
PILLOWS 127
Natural Fill Pillow 127
TABLE 48 COMPARISON OF NATURAL FILL PILLOWS 127
Synthetic Fill Pillow 128
Poly Cluster Fill Pillow 128
TABLE 49 SELECTED POLY CLUSTER PILLOWS 128
Memory Foam Pillows 128
TABLE 50 COMPARISON OF SELECTED MEMORY FOAM PILLOWS 129
Memory Foam Gel Pillows 129
TABLE 51 SELECTED MEMORY FOAM GEL PILLOWS 129
CHAPTER 8 SLEEP-AID MARKET SIZE AND GROWTH 131
MEDICATIONS 131
PRESCRIPTION SLEEP MEDICINES 131
OVER-THE-COUNTER SLEEP MEDICINES 132
HERBAL AND NATURAL SLEEP MEDICINES 132
SLEEP MEDICATION MARKET SIZE AND FORECAST 133
TABLE 52 GLOBAL MARKET FOR SLEEP-AID MEDICATIONS, BY TYPE, THROUGH
2021 ($ BILLIONS) 133
FIGURE 6 GLOBAL MARKET FOR SLEEP-AID MEDICATIONS, BY TYPE, 2015-2021 ($
BILLIONS) 133
Types of Prescription Sleep Medications 134
Nonbenzodiazepines 134
TABLE 53 HALF-LIFE AND DOSE RANGE OF NONBENZODIAZEPINES (HOUR/MG) 135
Benzodiazepines 135
TABLE 54 HALF-LIFE AND DOSAGE RANGE OF BENZODIAZEPINES (HOUR/MG) 135
Medications for Narcolepsy 136
TABLE 55 HALF-LIFE AND DOSAGE RANGE FOR NARCOLEPSY DRUGS (HOUR/MG) 136
Drugs for Restless Leg Syndrome 137
TABLE 56 HALF-LIFE AND DOSAGE RANGE OF DRUGS USED FOR RESTLESS LEG
SYNDROME (HOUR/MG) 137
Melatonin Receptor Agonists for Sleep Disorders 138
TABLE 57 HALF-LIFE AND DOSAGE RANGE FOR MELATONIN RECEPTOR AGONISTS
(HOUR/MG) 138
Global Market for Prescription Sleep Medications 138
TABLE 58 GLOBAL MARKET FOR PRESCRIPTION SLEEP-AID MEDICATIONS, BY TYPE,
THROUGH 2021 ($ BILLIONS) 139
FIGURE 7 GLOBAL MARKET FOR PRESCRIPTION SLEEP-AID MEDICATIONS, BY TYPE,
2015-2021 ($ BILLIONS) 139
Types of OTC/Herbal Drugs for Sleep Disorders 140
OTC Analgesics and Combination Drugs 140
TABLE 59 ANALGESICS AND COMBINATION DRUGS FOR SLEEP 140
OTC Antihistamines 140
TABLE 60 HALF-LIFE AND DOSAGE RANGE OF OTC ANTIHISTAMINES (HOURS/MG) 141
OTC Natural Sleep Aids 141
TABLE 61 SOME OTC NATURAL SLEEP AIDS AND THEIR INGREDIENTS 141
Global Market for OTC/Herbal Drugs for Sleep Disorders 141
TABLE 62 GLOBAL MARKET FOR OTC/HERBAL SUPPLEMENTS FOR SLEEP, BY TYPE,
THROUGH 2021 ($ BILLIONS) 142
FIGURE 8 GLOBAL MARKET FOR OTC/HERBAL SUPPLEMENTS FOR SLEEP, BY TYPE,
2015-2021 ($ BILLIONS) 142
GLOBAL MARKET FOR SLEEP-AID MEDICATIONS BY REGION 143
TABLE 63 GLOBAL MARKET FOR SLEEP MEDICATIONS, BY REGION, THROUGH 2021
($ BILLIONS) 144
FIGURE 9 GLOBAL MARKET FOR SLEEP MEDICATIONS, BY REGION, 2015-2021 ($
BILLIONS) 144
SLEEP APNEA DEVICES 145
FIGURE 10 GLOBAL MARKET FOR SLEEP APNEA DEVICES, 2015-2021 ($ BILLIONS) 146
GLOBAL MARKET FOR SLEEP APNEA DEVICES BY REGION 146
TABLE 64 GLOBAL MARKET FOR SLEEP APNEA DEVICES, BY REGION, THROUGH
2021 ($ BILLIONS) 147
FIGURE 11 GLOBAL MARKET FOR SLEEP APNEA DEVICES, BY REGION, 2015-2021
($ BILLIONS) 147
GLOBAL MARKET FOR CPAP DEVICES 148
FIGURE 12 GLOBAL MARKET FOR CPAP DEVICES, 2015-2021 ($ BILLIONS) 149
Global Market for Auto-PAP Devices 149
FIGURE 13 GLOBAL MARKET FOR APAP DEVICES, 2015-2021 ($ BILLIONS) 149
Unit Shipments of CPAP Devices in the U.S. 150
FIGURE 14 U.S. MARKET FOR CPAP DEVICES, 2015-2021 (NUMBER OF UNITS IN
THOUSANDS) 150
Unit Shipments of Bi-Level Devices in the U.S. 151
FIGURE 15 U.S. MARKET FOR BIPAP DEVICES, 2015-2021 (NUMBER OF UNITS IN
THOUSANDS) 151
Unit Shipments of APAP Devices in the U.S. 152
FIGURE 16 U.S. MARKET FOR APAP DEVICES, 2015-2021 (NUMBER OF UNITS IN
THOUSANDS) 152
U.S. Market for Sleep Apnea Devices by Product Type 153
FIGURE 17 U.S. MARKET FOR SLEEP APNEA DEVICES, BY DEVICE TYPE, 2015-2021
(NUMBER OF UNITS IN THOUSANDS) 154
SLEEP DISORDER TESTING 154
HOME SLEEP TEST DEVICES 154
FIGURE 18 GLOBAL MARKET FOR HST DEVICES, 2015-2021 ($ BILLIONS) 155
Cost Comparison of HST and PSG 155
TABLE 65 COST COMPARISON OF PSG AND HST ($) 156
Market Leaders in Home Sleep Testing Devices 156
FIGURE 19 MARKET SHARE OF HOME SLEEP TESTING DEVICES, BY COMPANY, 2015
(%) 157
SLEEP LABORATORIES 157
FIGURE 20 GLOBAL MARKET FOR SLEEP LABORATORIES, 2015-2021 ($ BILLIONS) 158
GLOBAL REVENUES FOR SLEEP LABORATORIES BY REGION 158
TABLE 66 GLOBAL MARKET FOR SLEEP LABORATORIES, BY REGION, THROUGH
2021 ($ BILLIONS) 159
FIGURE 21 GLOBAL MARKET FOR SLEEP LABORATORIES, BY REGION, 2015-2021 ($
BILLIONS) 159
Number of Sleep Centers in the U.S. 160
FIGURE 22 NUMBER OF ACCREDITED SLEEP CENTERS IN THE U.S, 1996-2015
(NUMBER OF SLEEP CENTERS) 160
AASM Accreditation Process for Sleep Centers 161
TABLE 67 ACCREDITATION PRICING 161
MATTRESSES AND PILLOWS 162
FIGURE 23 GLOBAL MARKET FOR MATTRESSES AND PILLOWS, BY REGION,
2015-2021 ($ BILLIONS) 162
GLOBAL MARKET FOR MATTRESSES AND PILLOWS BY REGION 162
TABLE 68 GLOBAL MARKET FOR MATTRESSES AND PILLOWS, BY REGION,
THROUGH 2021 ($ BILLIONS) 163
FIGURE 24 GLOBAL MARKET FOR MATTRESSES AND PILLOWS, BY REGION,
2015-2021 ($ BILLIONS) 163
FIGURE 25 GLOBAL MARKET FOR MATTRESSES AND PILLOWS, BY REGION, 2021 (%) 164
GLOBAL MATTRESS PRODUCTION BY MATERIAL 164
FIGURE 26 GLOBAL MATTRESS PRODUCTION, BY MATERIAL, 2015 (%) 164
Leading U.S. Mattress Companies 165
FIGURE 27 U.S. MARKET SHARES OF LEADING MATTRESS AND PILLOW VENDORS,
2015 (%) 167
Price Point Comparisons of Leading Mattresses 167
TABLE 69 PRICE POINT COMPARISON OF MATTRESSES, BY MARKET LEADERS ($) 167
Mattresses: The Leading Household Consumables 168
FIGURE 28 PERCENT USE OF NEW MATTRESSES IN RELATION TO OTHER
HOUSEHOLD CONSUMABLES (%) 168
CHAPTER 9 RECENT DEVELOPMENTS IN THE SLEEP INDUSTRY 171
NEW METHODS FOR PAP THERAPY DATA DOWNLOADING 171
OBJECTIVE MONITORING FOR INSOMNIA 171
FIRST FDA-APPROVED IMPLANTABLE NEUROSTIMULATION DEVICE 171
SURVEY ON ORAL APPLIANCE THERAPY 172
SWISS NARCOLEPSY SCALE 172
IMPROVED DAWN STIMULATION LIGHT 172
POSITIONAL COMBINATION THERAPY 173
COMFORT INNOVATIONS IN CPAP INTERFACES 173
SLEEP ANCHORING 174
AASM SLEEP 174
CHAPTER 10 SLEEP AIDS: MARKET SUMMARY 176
SLEEP AIDS AND TECHNOLOGIES GLOBAL MARKET 176
FIGURE 29 GLOBAL MARKET FOR SLEEP AIDS AND TECHNOLOGIES, 2015-2021 ($
BILLIONS) 176
TOTAL MARKET BY PRODUCT TYPE 176
TABLE 70 GLOBAL MARKET FOR SLEEP AIDS, BY TYPE, THROUGH 2021 ($ BILLIONS) 178
FIGURE 30 GLOBAL MARKET FOR SLEEP AIDS, BY TYPE, 2015-2021 ($ BILLIONS) 178
FIGURE 31 GLOBAL MARKET FOR SLEEP AIDS, BY TYPE, 2021 (%) 179
TOTAL SLEEP-AID MARKET BY REGION 180
TABLE 71 GLOBAL MARKET SHARE FOR SLEEP AIDS AND TECHNOLOGIES, BY
REGION, 2015-2021 (%) 181
FIGURE 32 GLOBAL MARKET SHARE FOR SLEEP AIDS AND TECHNOLOGIES, BY
REGION, 2015-2021 (%) 181
SLEEP INDUSTRY PARTICIPANTS BY PRODUCT TYPE 182
TABLE 72 SLEEP INDUSTRY PARTICIPANTS, BY MANUFACTURER 182
CHAPTER 11 COMPANY PROFILES 185
3B MEDICAL INC. 185
PRODUCTS 185
Aerie 185
Aloha 185
Ecco 186
Elara 186
Hybrid 186
iO Mini-Nasal 187
Luna 187
RESmart BPAP Auto Bi-level 187
RESmart Auto CPAP 188
RESmart CPAP 188
ACTIGRAPH LLC 188
PRODUCTS 189
ActiGraph Link 189
wGT3X-BT 189
ActiLife 189
ADVANCED BRAIN MONITORING INC. 190
PRODUCTS 190
Sleep Profiler 190
Apnea Guard 190
Night Shift 190
Sleep Profiler PSG2 191
AIRWAY LABS INC. 191
PRODUCTS 191
TAP 3 Elite 191
TAP 3 192
AMBULATORY MONITORING INC. 192
PRODUCTS 192
MotionLogger Actigraph 192
Inductotrace 192
APNEA SCIENCES CORP. 193
PRODUCT 193
ApneaRx 193
APNICURE INC. 193
PRODUCT 193
Winx 193
BLAIREX LABORATORIES INC. 194
PRODUCT 194
Sleepinal 194
BOEHRINGER INGELHEIM PHARMACEUTICALS INC. 194
PRODUCT 195
Mirapex 195
Sifrol 195
Pexola 195
Mirapex 195
BRAEBON MEDICAL CORP. 195
SELECTED SLEEP PRODUCTS 196
PureFlow 196
Disposable Airflow 196
MediByte Junior 196
MediByte 196
DentiTrac 197
CADWELL LABORATORIES INC. 197
SLEEP PRODUCTS 197
Easy III PSG 197
EASY Ambulatory PSG 197
CAMNTECH LTD. 198
PRODUCTS 198
MotionWatch 8 198
Pro-Diary 198
CAREFUSION CORP. 198
PRODUCTS 199
ApneaRx 199
Aura Nasal Mask 199
IQ Nasal Mask 199
MiniMe Nasal Mask 199
MiniMe 2 Nasal Mask 200
Mojo Full Face Mask 200
NOX T3 Portable Sleep Monitor 200
PureSom Headgear and Chinstrap 200
QDC-Pro 201
SomnoStar z4 Sleep System 201
Advantage Series Full Face Mask 201
Advantage Series Nasal Mask 201
Veraseal 2 Disposable Mask 201
CIRCADIANCE LLC 202
PRODUCTS 202
SleepWeaver Anew 202
SleepWeaver Elan 202
SleepWeaver Advance 202
SleepWeaver Advance Small 203
SleepWeaver Feather Weight Tube 203
SmartMonitor 2 203
NeoPAP 203
CLEVELAND MEDICAL DEVICES INC. 204
PRODUCTS 204
SleepView 204
SleepScout 204
Sapphire PSG 204
COMPUMEDICS LTD. 205
PRODUCTS 205
Grael 4K PSG/EEG 205
ProFusion Sleep Software 206
ProFusion NeXus LMS 206
HD Digital Video 207
Somte PSG 207
Siesta 802 PSG 208
TABLE 73 COMPUMEDICS' REVENUES, 2010-2015 ($ THOUSANDS) 208
DEVILBISS HEALTHCARE LTD. 208
PRODUCTS 209
IntelliPAP Standard 209
IntelliPAP AutoAdjust 209
IntelliPAP Bilevel 209
IntelliPAP AutoBilevel 209
NasalFit Deluxe EZ CPAP Mask 210
D100 Nasal CPAP Mask 210
EasyFit Nasal 210
EasyFit Lite Nasal Mask 211
EasyFit SilkGel Nasal Mask 211
DeVilbiss FlexSeta Nasal CPAP Mask 212
Innova Nasal CPAP Mask 212
DeVilbiss Serenity Nasal CPAP Mask 212
Nasal Aire II CPAP Interface 213
Full Face ComfortFit Deluxe CPAP Mask 213
Full Face ComfortFit Deluxe EZ CPAP Mask 213
D100 Full Face CPAP Mask 213
EasyFit Full Face Mask 214
EasyFit SilkGel Full Face Mask 214
Innova Full Face CPAP Mask 214
V2 Full Face Mask 215
Quest Full Face CPAP Mask 215
PillowFit Deluxe Nasal Pillow CPAP System 216
Aloha Nasal Pillow System 216
DISTAR LLC 216
PRODUCTS 217
Original TheraSnore 217
Adjustable TheraSnore 217
FISHER and PAYKEL HEALTHCARE CORP. LTD. 217
PRODUCTS 218
Full Face Masks 218
FandP Simplus 218
Nasal Masks 218
FandP Eson 218
FandP Eson 2 218
Nasal Pillow Mask 219
FandP Pilairo Q 219
CPAP Devices 219
FandP Icon+ Auto 219
FandP ICON+ Premo 219
FandP ICON+ Novo 219
TABLE 74 FISHER and PAYKEL'S REVENUES, 2011-2015 (NZ$ THOUSANDS) 220
GLIDEWELL LABORATORIES 220
PRODUCTS 220
Silent Nite sl 220
aveoTSD 220
EMA 221
TAP 3 Elite 221
HANS RUDOLPH INC. 221
PRODUCTS 221
HUMAN DESIGN MEDICAL 222
PRODUCTS 222
Z1 Auto 222
Z1 CPAP 222
Nitelog Mobile App 223
INNOMED TECHNOLOGIES INC. 223
PRODUCTS 223
Aspen 223
Aloha Nasal Pillow 223
Hybrid Universal Interface 223
Nasal-Aire II 224
Nasal-Aire II Petite 224
Bravo CPAP Interface 224
Bravo II Nasal Pillow System 224
Stylent NE Disposable Mask 224
INSPIRE MEDICAL SYSTEMS INC. 225
BRIEF HISTORY 225
INSPIRE THERAPY 225
ITAMAR MEDICAL LTD. 225
PRODUCT 226
WatchPAT 226
JOHNSON and JOHNSON 226
PRODUCT 226
Tylenol PM 226
MODERN DENTAL LABORATORY USA 226
PRODUCT 227
Moses 227
EMA 227
EMA First Step 227
NATUS MEDICAL INC. 227
PRODUCTS 228
Embla N7000 228
S4500 PSG Amplifier 228
Embletta MPR and MPR PG 228
Embla MDrive 228
Other Sleep Products 228
TABLE 75 NATUS MEDICAL'S REVENUES, 2009-2015 ($ THOUSANDS) 229
NIHON KOHDEN AMERICA INC. 229
PRODUCTS 229
PSG-1100 229
EEG/PSG Multi-Modality Sleep Studies 230
Nomad 230
Sphinx 230
NORTHEAST MONITORING INC. 231
PRODUCT 231
LX Sleep Software 231
NOVASOM INC. 231
PRODUCT 232
AccuSom 232
NOX MEDICAL 232
PRODUCTS 232
Nox T3 Sleep Monitor 232
Nox A1 PSG System 233
PERNIX THERAPEUTICS HOLDINGS INC. 233
PRODUCT 233
Silenor 233
PFIZER INC. 234
PRODUCTS 234
Advil PM 234
Zaleplon 234
TABLE 76 PFIZER'S REVENUES, 2011-2015 ($ MILLIONS) 234
RESMED INC. 235
PRODUCTS 235
Nasal Pillow Mask 235
AirFit P10 235
AirFit N10 235
Swift FX Nano 235
Mirage Micro 236
Mirage SoftGel 236
Full Face Masks 236
Quattro-Air 236
Mirage Quattro 236
Pixi 236
Mirage Kidsta 236
Devices 237
AirSense 10 AutoSet 237
S9 AutoSet 237
S9 Escape Auto 237
S9 Auto 25 237
TABLE 77 RESMED'S REVENUES, 2009-2015 ($ THOUSANDS) 237
RESPIRONICS INC. 238
PRODUCTS 238
DreamStation Auto CPAP 238
BiPAP Auto with Bi-Flex 239
BiPAP Auto with Bi-Flex 239
REMstar Auto with A-Flex 240
REMstar SE 240
Alice 6 LDx 240
Alice 6 LDE 240
Alice NightOne 241
Alice PDx 241
RUSleeping RTS 241
Sleepware G3 with Somnolyzer 241
Sleep Diagnostic Somnolyzer 24x7 Scoring Solution 241
Actigraph 2 242
Actiwatch Spectrum PRO 242
Actiwatch Spectrum Plus 242
DreamMapper 243
DreamWear Nasal CPAP Mask 243
AmaraView 243
Wisp 243
TABLE 78 PHILIPS HEALTHCARE REVENUES, 2010-2015 ($ MILLIONS) 244
SANOFI 244
PRODUCTS 244
Zolpidem 244
TABLE 79 SANOFI'S REVENUES, 2008-2015 (€ MILLIONS) 244
SELECT COMFORT CORP. 245
PRODUCT 245
Classic Series Mattresses 245
The Sleep Number c2 Bed 245
Sleep Number c3 Bed 245
Sleep Number c4 Bed 246
Performance Series Mattresses 246
Sleep Number p5 Bed 246
Sleep Number p6 Bed 247
Memory Foam Series Mattresses 247
Sleep Number m9 Bed 247
Sleep Number m7 Bed 247
Innovation Series Mattresses 248
Sleep Number i8 Bed 248
Sleep Number i10 Bed 248
Sleep Number x12 Bed 248
Specialty Beds 248
Sleep Number RV Mattress Deluxe 248
Sleep Number RV Mattress Premier 249
TABLE 80 SELECT COMFORT'S REVENUES, 2008-2015 ($ MILLIONS) 249
SERTA INC. 249
PRODUCTS 250
Innerspring Mattresses 250
Perfect Sleeper Essentials 250
Perfect Sleeper Smart Surface 250
Memory Foam Mattresses 251
iComfort 251
iComfort Directions 251
iComfort EFX 251
iComfort Perfect Elements 251
Memory Foam Hybrid Mattresses 252
Perfect Day iSeries 252
Trump Home iSeries 252
Bellagio at Home iSeries 252
SIMMONS BEDDING CO. 252
PRODUCTS 253
SimmonsCURV 253
Simmons BeautySleep 253
SOMNETICS INTERNATIONAL INC. 253
PRODUCTS 253
Transcend AUTO Mini CPAP 253
Transcend EEX Mini CPAP 254
Transcend Mini CPAP 254
SLEEPVIRTUAL/NEUROVIRTUAL 254
PRODUCTS 254
BWII Portable PSG 254
BW3 PSG/EEG 254
SOMNOMED LTD. 255
PRODUCTS 255
SomnoDent 255
SomnoBrux 255
SOMNOMEDICS LLC 255
PRODUCTS 256
SomnoScreen Plus PSG 256
SomnoWatch Actigraphy 256
SomnoWatch Plus RESP 256
SUNOVION PHARMACEUTICALS INC. 256
PRODUCT 257
Lunesta 257
SYNTHON BV 257
TAKEDA PHARMACEUTICAL CO. LTD. 257
PRODUCT 257
Rozerem 257
TABLE 81 TAKEDA'S REVENUES, 2009-2015 (Â¥ MILLIONS) 258
TEMPUR SEALY INTERNATIONAL INC. 258
PRODUCTS 258
Tempur-Pedic 258
Tempur 258
Sealy Posturepedic 259
Sealy Optimum 259
TABLE 82 TEMPUR SEALY'S REVENUES, 2009-2015 ($ MILLIONS) 259
TEVA PHARMACEUTICAL INDUSTRIES LTD. 259
PRODUCTS 260
Provigil (Modafinil) 260
Nuvigil (Armodafinil) 260
TOMED GMBH 260
PRODUCTS 260
SomnoGuard AP 2 260
SomnoGuard SP 261
SomnoGuard 3 261
SomnoGuard AP PRO 262
VANDA PHARMACEUTICALS 262
PRODUCT 262
Heltioz (Trazimelteon) 262
WEINMANN GERATE FUR MEDIZIN GMBH + CO. KG 263
PRODUCTS 263
XENOPORT INC. 264
BRIEF HISTORY 264
PRODUCT 264
Horizant (Gabapentin Enacarbil) 264

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