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Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline Review, H1 2016

Summary

Global Markets Direct’s, ‘Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline Review, H1 2016’, provides an overview of the Cognitive Impairment Associated With Schizophrenia (CIAS) pipeline landscape.

The report provides comprehensive information on the therapeutics under development for Cognitive Impairment Associated With Schizophrenia (CIAS), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. The report also covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases. Additionally, the report provides an overview of key players involved in therapeutic development for Cognitive Impairment Associated With Schizophrenia (CIAS) and features dormant and discontinued projects.

Global Markets Direct’s report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct’s proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources. Drug profiles featured in the report undergoes periodic review following a stringent set of processes to ensure that all the profiles are updated with the latest set of information. Additionally, various dynamic tracking processes ensure that the most recent developments are captured on a real time basis.

The report helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage.

Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data.

Scope

- The report provides a snapshot of the global therapeutic landscape of Cognitive Impairment Associated With Schizophrenia (CIAS)
- The report reviews pipeline therapeutics for Cognitive Impairment Associated With Schizophrenia (CIAS) by companies and universities/research institutes based on information derived from company and industry-specific sources
- The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages
- The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
- The report reviews key players involved Cognitive Impairment Associated With Schizophrenia (CIAS) therapeutics and enlists all their major and minor projects
- The report assesses Cognitive Impairment Associated With Schizophrenia (CIAS) therapeutics based on drug target, mechanism of action (MoA), route of administration (RoA) and molecule type
- The report summarizes all the dormant and discontinued pipeline projects
- The report reviews latest news related to pipeline therapeutics for Cognitive Impairment Associated With Schizophrenia (CIAS)

Reasons to buy

- Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
- Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
- Identify and understand important and diverse types of therapeutics under development for Cognitive Impairment Associated With Schizophrenia (CIAS)
- Identify potential new clients or partners in the target demographic
- Develop strategic initiatives by understanding the focus areas of leading companies
- Plan mergers and acquisitions effectively by identifying key players and it’s most promising pipeline therapeutics
- Devise corrective measures for pipeline projects by understanding Cognitive Impairment Associated With Schizophrenia (CIAS) pipeline depth and focus of Indication therapeutics
- Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope
- Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline

Table Of Contents

Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline Review, H1 2016
Table of Contents
Table of Contents 2
List of Tables 7
List of Figures 8
Introduction 9
Global Markets Direct Report Coverage 9
Cognitive Impairment Associated With Schizophrenia (CIAS) Overview 10
Therapeutics Development 11
Pipeline Products for Cognitive Impairment Associated With Schizophrenia (CIAS) - Overview 11
Cognitive Impairment Associated With Schizophrenia (CIAS) - Therapeutics under Development by Companies 12
Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline Products Glance 14
Late Stage Products 14
Clinical Stage Products 15
Early Stage Products 16
Cognitive Impairment Associated With Schizophrenia (CIAS) - Products under Development by Companies 17
Cognitive Impairment Associated With Schizophrenia (CIAS) - Companies Involved in Therapeutics Development 19
AbbVie Inc. 19
Amarantus Bioscience Holdings, Inc. 20
Astellas Pharma Inc. 21
AstraZeneca Plc 22
Avineuro Pharmaceuticals, Inc. 23
Bristol-Myers Squibb Company 24
Eli Lilly and Company 25
FORUM Pharmaceuticals Inc. 26
H. Lundbeck A/S 27
Intra-Cellular Therapies, Inc. 28
Iproteos S.L. 29
Luc Therapeutics, Inc. 30
Neuralstem, Inc. 31
Pfizer Inc. 32
Saniona AB 33
SK Biopharmaceuticals Co., Ltd. 34
Spherium Biomed S.L. 35
Sunovion Pharmaceuticals Inc. 36
Takeda Pharmaceutical Company Limited 37
Vanda Pharmaceuticals Inc. 38
Cognitive Impairment Associated With Schizophrenia (CIAS) - Therapeutics Assessment 39
Assessment by Monotherapy Products 39
Assessment by Target 40
Assessment by Mechanism of Action 42
Assessment by Route of Administration 44
Assessment by Molecule Type 45
Drug Profiles 47
A-431404 - Drug Profile 47
Product Description 47
Mechanism of Action 47
RandD Progress 47
AN-761 - Drug Profile 48
Product Description 48
Mechanism of Action 48
RandD Progress 48
AQW-051 - Drug Profile 49
Product Description 49
Mechanism of Action 49
RandD Progress 49
ASP-4345 - Drug Profile 51
Product Description 51
Mechanism of Action 51
RandD Progress 51
ASP-5736 - Drug Profile 52
Product Description 52
Mechanism of Action 52
RandD Progress 52
AUT-1 - Drug Profile 53
Product Description 53
Mechanism of Action 53
RandD Progress 53
AUT-6 - Drug Profile 54
Product Description 54
Mechanism of Action 54
RandD Progress 54
AUT-9 - Drug Profile 55
Product Description 55
Mechanism of Action 55
RandD Progress 55
AVL-3288 - Drug Profile 56
Product Description 56
Mechanism of Action 56
RandD Progress 56
AVN-211 - Drug Profile 57
Product Description 57
Mechanism of Action 57
RandD Progress 57
DSP-3748 - Drug Profile 58
Product Description 58
Mechanism of Action 58
RandD Progress 58
eltoprazine - Drug Profile 59
Product Description 59
Mechanism of Action 59
RandD Progress 59
encenicline hydrochloride - Drug Profile 62
Product Description 62
Mechanism of Action 62
RandD Progress 62
erteberel - Drug Profile 65
Product Description 65
Mechanism of Action 65
RandD Progress 65
FRM-17874 - Drug Profile 66
Product Description 66
Mechanism of Action 66
RandD Progress 66
IC-041 - Drug Profile 67
Product Description 67
Mechanism of Action 67
RandD Progress 67
IPR-001 - Drug Profile 68
Product Description 68
Mechanism of Action 68
RandD Progress 68
IPR-088 - Drug Profile 69
Product Description 69
Mechanism of Action 69
RandD Progress 69
IPR-19 - Drug Profile 70
Product Description 70
Mechanism of Action 70
RandD Progress 70
ITI-214 - Drug Profile 71
Product Description 71
Mechanism of Action 71
RandD Progress 71
LUAF-64280 - Drug Profile 72
Product Description 72
Mechanism of Action 72
RandD Progress 72
NSI-189 - Drug Profile 73
Product Description 73
Mechanism of Action 73
RandD Progress 73
PF-04958242 - Drug Profile 75
Product Description 75
Mechanism of Action 75
RandD Progress 75
PNU-120596 - Drug Profile 77
Product Description 77
Mechanism of Action 77
RandD Progress 77
roflumilast - Drug Profile 78
Product Description 78
Mechanism of Action 78
RandD Progress 78
SEN-15924 - Drug Profile 81
Product Description 81
Mechanism of Action 81
RandD Progress 81
SKL-15508 - Drug Profile 82
Product Description 82
Mechanism of Action 82
RandD Progress 82
SKL-A4R - Drug Profile 83
Product Description 83
Mechanism of Action 83
RandD Progress 83
Small Molecules for Cognitive Impairment Associated with Schizophrenia - Drug Profile 84
Product Description 84
Mechanism of Action 84
RandD Progress 84
Small Molecules to Agonize Dopamine D1 Receptor for Cognitive Impairment Associated with Schizophrenia - Drug Profile 85
Product Description 85
Mechanism of Action 85
RandD Progress 85
Small Molecules to Agonize NMDA2B for Cognitive Impairment Associated With Schizophrenia - Drug Profile 86
Product Description 86
Mechanism of Action 86
RandD Progress 86
SP-14040 - Drug Profile 88
Product Description 88
Mechanism of Action 88
RandD Progress 88
TAK-058 - Drug Profile 89
Product Description 89
Mechanism of Action 89
RandD Progress 89
TAK-831 - Drug Profile 90
Product Description 90
Mechanism of Action 90
RandD Progress 90
TAK-915 - Drug Profile 91
Product Description 91
Mechanism of Action 91
RandD Progress 91
VU-0467154 - Drug Profile 92
Product Description 92
Mechanism of Action 92
RandD Progress 92
Cognitive Impairment Associated With Schizophrenia (CIAS) - Recent Pipeline Updates 93
Cognitive Impairment Associated With Schizophrenia (CIAS) - Dormant Projects 106
Cognitive Impairment Associated With Schizophrenia (CIAS) - Discontinued Products 108
Cognitive Impairment Associated With Schizophrenia (CIAS) - Product Development Milestones 109
Featured News and Press Releases 109
Nov 11, 2015: FORUM Pharmaceuticals Announces Removal of Partial Clinical Hold on Phase 3 Encenicline Program for Cognitive Impairment in Schizophrenia 109
Sep 14, 2015: FORUM Pharmaceuticals Updates Encenicline Phase 3 Clinical Trial Programs in Alzheimer's Disease and Cognitive Impairment in Schizophrenia 109
Jul 15, 2015: FORUM Pharmaceuticals Announces Publication of Encenicline Phase 2 Clinical Trial Results for Cognitive Impairment in Schizophrenia 109
Jun 22, 2015: FORUM Pharmaceuticals Receives FDA Fast Track Designation for Lead Compound Encenicline to Treat Cognitive Impairment in Schizophrenia 110
Jun 11, 2015: FORUM Pharmaceuticals Completes Patient Enrollment in Pivotal Phase 3 Clinical Trial Program of Encenicline for Cognitive Impairment in Schizophrenia 111
Feb 01, 2015: ASCIL Biopharm cooperates in a Project awarded with a “RETOS-Colaboración” grant 112
Apr 17, 2013: SK Biopharma Announces FDA's Authorization Of IND For SKL15508 For Treatment Of Cognitive Impairment Associated With Schizophrenia 112
Feb 19, 2013: Intra-Cellular Therapies Completes Phase I Single Rising Dose Trial Of Selective Phosphodiesterase 1 Inhibitor 112
Appendix 114
Methodology 114
Coverage 114
Secondary Research 114
Primary Research 114
Expert Panel Validation 114
Contact Us 114
Disclaimer 115

List of Tables
Number of Products under Development for Cognitive Impairment Associated With Schizophrenia (CIAS), H1 2016 11
Number of Products under Development by Companies, H1 2016 13
Comparative Analysis by Late Stage Development, H1 2016 14
Comparative Analysis by Clinical Stage Development, H1 2016 15
Comparative Analysis by Early Stage Development, H1 2016 16
Products under Development by Companies, H1 2016 17
Products under Development by Companies, H1 2016 (Contd..1) 18
Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by AbbVie Inc., H1 2016 19
Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Amarantus Bioscience Holdings, Inc., H1 2016 20
Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Astellas Pharma Inc., H1 2016 21
Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by AstraZeneca Plc, H1 2016 22
Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Avineuro Pharmaceuticals, Inc., H1 2016 23
Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Bristol-Myers Squibb Company, H1 2016 24
Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Eli Lilly and Company, H1 2016 25
Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by FORUM Pharmaceuticals Inc., H1 2016 26
Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by H. Lundbeck A/S, H1 2016 27
Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Intra-Cellular Therapies, Inc., H1 2016 28
Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Iproteos S.L., H1 2016 29
Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Luc Therapeutics, Inc., H1 2016 30
Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Neuralstem, Inc., H1 2016 31
Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Pfizer Inc., H1 2016 32
Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Saniona AB, H1 2016 33
Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by SK Biopharmaceuticals Co., Ltd., H1 2016 34
Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Spherium Biomed S.L., H1 2016 35
Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Sunovion Pharmaceuticals Inc., H1 2016 36
Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Takeda Pharmaceutical Company Limited, H1 2016 37
Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Vanda Pharmaceuticals Inc., H1 2016 38
Assessment by Monotherapy Products, H1 2016 39
Number of Products by Stage and Target, H1 2016 41
Number of Products by Stage and Mechanism of Action, H1 2016 43
Number of Products by Stage and Route of Administration, H1 2016 44
Number of Products by Stage and Molecule Type, H1 2016 46
Cognitive Impairment Associated With Schizophrenia (CIAS) Therapeutics - Recent Pipeline Updates, H1 2016 93
Cognitive Impairment Associated With Schizophrenia (CIAS) - Dormant Projects, H1 2016 106
Cognitive Impairment Associated With Schizophrenia (CIAS) - Dormant Projects (Contd..1), H1 2016 107
Cognitive Impairment Associated With Schizophrenia (CIAS) - Discontinued Products, H1 2016 108

List of Figures
Number of Products under Development for Cognitive Impairment Associated With Schizophrenia (CIAS), H1 2016 11
Number of Products under Development by Companies, H1 2016 12
Comparative Analysis by Clinical Stage Development, H1 2016 15
Comparative Analysis by Early Stage Products, H1 2016 16
Assessment by Monotherapy Products, H1 2016 39
Number of Products by Top 10 Targets, H1 2016 40
Number of Products by Stage and Top 10 Targets, H1 2016 40
Number of Products by Top 10 Mechanism of Actions, H1 2016 42
Number of Products by Stage and Top 10 Mechanism of Actions, H1 2016 42
Number of Products by Stage and Routes of Administration, H1 2016 44
Number of Products by Molecule Types, H1 2016 45
Number of Products by Stage and Molecule Types, H1 2016 45

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