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This BCC Research report provides an overview of the current state of the microRNA (miRNA) market, focusing mainly on continuing research endeavors, newly emerging sophisticated tools, reagents, techniques, diagnostics and therapeutic products.

Use this report to:
- Learn about the current state of the microRNA market, focusing mainly on continuing research endeavors, newly emerging sophisticated tools, reagents, techniques,
diagnostics and therapeutic products.
- Focus on the products and tests currently on the market and receive detailed analysis of the competitive environments.
- Evaluate emerging commercial opportunities in the microRNA reagent, diagnostic, and therapeutic submarkets.
- Receive profiles of leading players in the industry.

Highlights
- The global market for microRNA (miRNA) research tools, services, diagnostics, and drug discovery was valued at $478.8 million in 2013. This market is expected to reach $572 million in 2014 and $1 billion in 2019, increasing at a compound annual growth rate (CAGR) of 12.6% for the period of 2014 to 2019.
- The miRNA research tools market is expected to increase from $441.2 million in 2014 to $813.2 million by 2019, at a CAGR of 13% for the period of 2014 to 2019.
- The miRNA drug discovery market is expected to increase from $83 million in 2014 to $145.5 million in 2019, at a CAGR of 11.9% for the period of 2014 to 2019.

Introduction & Scope

INTRODUCTION

STUDY GOALS AND OBJECTIVES
This BCC Research report, MicroRNA Research Tools, Diagnostics and Therapeutics: Global Markets, provides an overview of the current state of the microRNA (miRNA)
market, focusing mainly on continuing research endeavors, newly emerging sophisticated tools, reagents, techniques, diagnostics and therapeutic products. The report describes products and tests currently on the market and a detailed analysis of the competitive environments, including new emerging trends and markets for novel
products and assay development.

REASONS FOR DOING THIS STUDY
MicroRNAs are a recently discovered class of gene regulators, which, when produced by a cell, are able to turn off specific sets of genes through post-transcriptional
mechanisms. They include a large family of small ~21-nucleotide long, noncoding (nRNAs) that are capable of controlling a variety of cellular processes such as cell
proliferation, differentiation and apoptosis. MicroRNAs are found to be regulating a wide array of gene targets and therefore may exert diverse, highly potent and
context-dependent functions. The last decade witnessed significant advancement in miRNA research leading to identification of novel miRNA genes, validation of miRNA
targets and delineation of the biological significance of miRNAs.

A growing number of pharmaceutical and biotech companies are becoming involved in miRNA research due to advancements in molecular diagnostics and therapeutics.
Consequently, a larger number of distribution companies are providing miRNA research tools and expanding the spectrum of their applications to cater to a wider range of life
sciences areas. Research on miRNA has expanded, embracing cardiovascular, virology, endocrinology, plant science and genetic disease fields.

As an increasing number of miRNAs and their functions are discovered, additional research fields may evince an interest in the role of miRNAs in their disciplines, leading
to the need for a wider variety of research tools. An upswing in miRNA research over the past few years has already led several life sciences vendors to offer miRNA
research tools. This report from BCC Research provides an insight into the various segments of the miRNA industry for the benefit of its participants in the segments of
research tools such as reagents, devices and diagnostics and miRNA therapeutics.

SCOPE AND FORMAT
This BCC Research report is a business tool that is intended to help biotechnology companies evaluate emerging commercial opportunities in the microRNA reagent,
diagnostic and therapeutic submarkets. The existing leading players in this market segment are provided with an opportunity to learn what the other competitors in this
nascent arena have achieved to gain a stronger foothold in the sector in their quest for bringing to the market blockbuster therapeutics to treat diseases with significant
unmet medical needs.

Table Of Contents

MicroRNA Research Tools, Diagnostics and Therapeutics: Global Markets
TABLE OF CONTENTS
CHAPTER 1 INTRODUCTION 2
STUDY GOALS AND OBJECTIVES 2
REASONS FOR DOING THIS STUDY 2
SCOPE AND FORMAT 3
METHODOLOGY AND INFORMATION SOURCES 3
INTENDED AUDIENCE 3
ANALYST'S CREDENTIALS 3
RELATED BCC RESEARCH REPORTS 3
BCC RESEARCH WEBSITE 4
DISCLAIMER 4
CHAPTER 2 EXECUTIVE SUMMARY 6
SUMMARY TABLE GLOBAL MARKET FOR MICRORNA RESEARCH TOOLS, SERVICES,
DIAGNOSTICS AND DRUG DISCOVERY, THROUGH 2019 ($ MILLIONS) 7
SUMMARY FIGURE GLOBAL MARKET FOR MICRORNA RESEARCH TOOLS, SERVICES,
DIAGNOSTICS AND DRUG DISCOVERY, 2013-2019 ($ MILLIONS) 7
CHAPTER 3 INTRODUCTION TO MICRORNA RESEARCH 9
HISTORICAL OVERVIEW OF MICRORNA RESEARCH 9
TABLE 1 MICRORNA TIMELINE 10
LANDMARK DISCOVERIES IN MICRORNA 11
Discovery of lin-4 in 1993 11
Discovery of let-7 in 2000 11
Discovery of miRNA in Plants in 2002 12
Discovery of miRNA Alterations in Cancer Cells (miR15 and miR16) in
2002 12
Discovery of miRNA Genes in Cancer-Associated Genomic Regions in
2004 12
Discovery of miRNA-Target Interaction Relevant to Cancer in 2005 12
Discovery of miRNA Deregulation in Cancer Metastasis in 2007 13
Discovery of miR-373 in 2008 13
Development of Proof of Concept of miRNA Delivery as Cancer
Therapy in 2009 13
Discovery of miRNA as Molecular Decoys in 2010 13
Discovery of Food-Derived Exogenous miRNAs in Serum and Plasma
in 2012 13
NOMENCLATURE OF MICRORNA 14
BIOGENESIS OF MICRORNA 14
FIGURE 1 BIOGENESIS OF MICRORNA 14
MICRORNA RESEARCH BY ORGANISM 16
FIGURE 2 MICRORNA RESEARCH SHARE BY ORGANISM, 2013 (%) 16
MICRORNA RESEARCH BY AREA 17
FIGURE 3 MICRORNA RESEARCH SHARES BY AREA, 2013 (%) 17
MICRORNAS ASSOCIATED WITH HUMAN DISEASES 18
TABLE 2 MICRORNA ASSOCIATED WITH HUMAN DISEASES 18
TABLE 3 EXIQON MICRORNA RESEARCH GRANT PROGRAMS, 2011-2014 23
GROWTH IN MICRORNA DATABASE 25
FIGURE 4 GROWTH OF MICRORNA DATABASE, 2002-2013 (NUMBER) 25
PEER-REVIEWED SCIENTIFIC PUBLICATIONS ON MICRORNA 26
FIGURE 5 PEER-REVIEWED SCIENTIFIC PUBLICATIONS ON MICRORNA, 2003-2013
(NUMBER OF PUBLICATIONS) 26
PATENTS RELATED TO MICRORNA 27
MICRORNA PATENTS BY TECHNOLOGICAL CATEGORY 27
TABLE 4 PERCENTAGE SHARE OF MICRORNA PATENTS BY TECHNOLOGICAL
CATEGORY, 2013 (%) 28
TABLE 5 U.S. PATENT APPLICATIONS RELATED TO MICRORNA, 2014 28
MICRORNA PATENTS BY DISEASE CATEGORY 31
TABLE 6 PERCENTAGE OF MICRORNA PATENTS BY DISEASE CATEGORY, 2013 (%) 31
MAJOR COLLABORATIONS WITHIN THE MICRORNA MARKET IN 2013 AND 2014 32
SANTARIS PHARMA A/S AND MIRAGEN THERAPEUTICS INC. 32
SANTARIS PHARMA A/S AND BRISTOL-MYERS SQUIBB CO. 32
SANTARIS PHARMA A/S AND PFIZER INC. 32
SANTARIS PHARMA A/S AND SHIRE PLC 33
SANTARIS PHARMA A/S AND WYETH PHARMACEUTICALS 33
SANTARIS PHARMA A/S AND GLAXOSMITHKLINE 33
MARINA BIOTECH AND MIRNA THERAPEUTICS 33
GLOBAL MARKET FOR MICRORNA RESEARCH TOOLS 34
FIGURE 6 GLOBAL MARKET FOR MICRORNA RESEARCH TOOLS, 2013-2019 ($
MILLIONS) 35
GLOBAL MARKET FOR MICRORNA RESEARCH PRODUCTS BY
GEOGRAPHICAL REGION 35
FIGURE 7 GLOBAL MARKET SHARES OF MICRORNA RESEARCH PRODUCTS BY
REGION, 2013 (%) 36
CHAPTER 4 MICRORNA-TARGETED THERAPEUTICS: AN OVERVIEW 38
RNA THERAPEUTICS: FOURTH MOST IMPORTANT EMERGING TECHNOLOGY IN
2014 38
TABLE 7 TOP 10 EMERGING TECHNOLOGIES IN 2014 38
DISEASE CLASSES ADDRESSED BY MICRORNA THERAPEUTICS 38
TABLE 8 DISEASE CLASSES ADDRESSED BY MICRORNA THERAPEUTICS 39
CURRENT STATUS OF MICRORNA-TARGETING THERAPEUTICS 39
TABLE 9 CURRENT CLINICAL APPLICATIONS TARGETING MICRORNA 40
Anti-miR-122 Therapy against Chronic Hepatitis C 40
FIGURE 8 INHIBITION OF MIR-122 BY MIRAVIRSEN 40
miR-34 Mimics as a Therapeutic against Primary and Metastatic Liver
Cancer 42
Preclinical In Vivo Experiments with MicroRNA 42
TABLE 10 A SMALL SAMPLE OF PRECLINICAL IN VIVO EXPERIMENTS WITH
MICRORNA 42
COMPANIES DEVELOPING MICRORNA TECHNOLOGIES AND THERAPEUTICS 45
TABLE 11 SELECTED COMPANIES DEVELOPING MICRORNA THERAPEUTICS 45
miRagen Therapeutics and Santaris Pharma 47
Regulus Therapeutics 47
Mirna Therapeutics 47
ADVANTAGES OF MICRORNA THERAPEUTICS 47
THERAPEUTIC TARGETING OF CARDIOVASCULAR MICRORNAS 48
TABLE 12 THERAPEUTIC TARGETING OF CARDIOVASCULAR MICRORNA 48
MICRORNA-TARGETED DRUG DISCOVERY MARKET 49
FIGURE 9 GLOBAL MICRORNA DRUG DISCOVERY MARKET, 2013-2019 ($ MILLIONS) 50
CHAPTER 5 MICRORNA SERVICE SECTOR: AN OVERVIEW 52
MICRORNA SERVICE PROVIDERS 52
TABLE 13 SELECTED COMPANIES OFFERING MICRORNA PROFILING SERVICES 52
SELECTED MICRORNA SERVICE PROVIDERS 53
miRNA Services from Applied Biological Materials Inc. 53
TABLE 14 PRICES OF RNA SEQUENCING SERVICES BY ABM ($) 53
miRNA Services from Asuragen 53
Biomarker Solutions 54
Platform and Technologies 54
Next-Generation Sequencing Services 54
miRNA Services from Cogenics 54
RNA Extraction and Biobanking 54
miRNA Profiling 55
Microarray Analysis 55
qRT-PCR 56
Experimental Design, Bioinformatics and Data Analysis 56
miRNA Services from Dharmacon (GE Healthcare Life Sciences) 56
miRNA Phenotypic Screening: Functional Characterization of
miRNA Biology 57
Functional Characterization of miRNAs 57
miRNA Services from Exiqon 57
Biomarker Discovery from Exiqon 57
miRNA Services from Comprehensive Biomarker Center GmbH 58
miRNA Profiling 58
miRNA Services from Genome Explorations 58
miRNA Services from LC Sciences 59
miRNA Sequencing Service 59
miRNA Microarray Service 59
miRNA qRT-PCR Service 59
Degradome Sequencing 59
Seq-Array for miRNA Discovery and Profiling 60
Services from Life Technologies 60
Total RNA Isolation from Cells or Tissues 60
miRNA Isolation from Cells, Tissues or Total RNA 60
NCode miRNA Microarray Expression Profiling 60
NCode SYBR Green miRNA qRT-PCR Analysis 61
TaqMan Service Provider Programs (Life Technologies) 61
TABLE 15 TAQMAN SERVICE PROVIDERS 61
Services from Oxford Gene Technology 62
TABLE 16 PREDESIGNED MICROARRAYS FROM OXFORD GENE TECHNOLOGY 62
Services from ServiceXS 62
TABLE 17 SERVICEXS' SOLUTIONS FOR RNA ANALYSIS 63
Services from System Biosciences Inc. 63
MicroRNA Expression Profiling Services 63
SBI's Custom Service to Profile Serum miRNAs 64
miRNA Services from Affymetrix 64
TABLE 18 AFFYMETRIX SERVICES PRICE LIST ($) 65
NGS-Specific Service Providers 65
TABLE 19 LIST OF SELECTED NGS-SPECIFIC SERVICE PROVIDERS 66
MICRORNA SERVICE MARKET 68
FIGURE 10 GLOBAL MICRORNA SERVICES MARKET, 2013-2019 ($ MILLIONS) 69
CHAPTER 6 MICRORNA IN DIAGNOSTICS: AN OVERVIEW 71
POTENTIAL USES OF MICRORNA AS BIOMARKERS FOR DIAGNOSIS 71
MAJOR APPLICATIONS OF MICRORNA AS BIOMARKERS 72
TABLE 20 MAJOR APPLICATIONS OF MICRORNA AS BIOMARKERS 72
COMPARISON OF VARIOUS MICRORNA DETECTION METHODS IN DIAGNOSTICS 73
TABLE 21 COMPARISON OF VARIOUS MICRORNA DETECTION METHODS 73
ROSETTA GENOMICS' LEADERSHIP IN MICRORNA-BASED DIAGNOSTICS 74
ROSETTA GENOMICS' CANCER ORIGIN TEST 74
ROSETTA GENOMICS' LUNG CANCER TEST 74
ROSETTA GENOMICS' KIDNEY CANCER TEST 74
ROSETTA GENOMICS' MESOTHELIOMA TEST 75
MICRORNA AS CANCER DIAGNOSTICS 75
TABLE 22 EXPRESSION PROFILE OF MICRORNA IN DIFFERENT TYPES OF CANCERS 75
CIRCULATING MICRORNAS AS CANCER DIAGNOSTICS 76
Prostrate Cancer 76
TABLE 23 SELECTED CIRCULATING MICRORNA REPORTED TO BE BIOMARKERS FOR
PROSTRATE CANCER 76
Breast Cancer 77
TABLE 24 SELECTED CIRCULATING MICRORNAS AS BIOMARKERS FOR BREAST
CANCER 78
Lung Cancer 79
TABLE 25 CIRCULATING MICRORNA AS BIOMARKERS FOR LUNG CANCER 79
GLOBAL MARKET FOR MICRORNA DIAGNOSTICS 81
FIGURE 11 GLOBAL MICRORNA DIAGNOSTICS MARKET, 2013-2019 ($ MILLIONS) 82
CHAPTER 7 BIOINFORMATICS: APPLICATIONS IN MICRORNA RESEARCH 84
MICRORNA TARGET PREDICTION TOOLS 84
POPULAR COMPUTATIONAL TOOLS 84
miRanda 84
TABLE 26 PROFILE OF MIRANDA 84
miRanda-mirSVR 85
TABLE 27 PROFILE OF MIRANDA-MIRSVR 85
TargetScan 85
TABLE 28 PROFILE OF TARGETSCAN 85
DIANA-micro T-CDS 86
TABLE 29 PROFILE OF DIANA-MICRO T-CDS 86
MirTarget2 86
TABLE 30 PROFILE OF MIRTARGET2 86
rna-22-GUI 87
TABLE 31 PROFILE OF RNA-22-GUI 87
TargetMiner 87
TABLE 32 PROFILE OF TARGETMINER 87
SVMicrO 88
TABLE 33 PROFILE OF SVMICRO 88
Probability of Interaction by Target Accessibility (PITA) 88
TABLE 34 PROFILE OF PITA 88
RNAhybrid 89
TABLE 35 PROFILE OF RNAHYBRID 89
MICRORNA DATABASES 89
miRBase Database 89
deepBase 89
microRNA.org 90
miRGen 2.0 90
miRNAMap 90
PMRD 90
MICRORNA NGS DATA ANALYSIS TOOLS 91
miRanalyzer 91
miRCat 91
miRDeep Package 91
miRExpress 91
GLOBAL BIOINFORMATICS MARKET 92
FIGURE 12 GLOBAL BIOINFORMATICS MARKET, 2013-2019 ($ BILLIONS) 93
CHAPTER 8 MICRORNA TECHNOLOGIES: AN OVERVIEW 95
MICRORNA PROFILING 95
MICRORNA PROFILING METHODS 96
TABLE 36 IMPORTANT MICRORNA PROFILING TECHNOLOGIES AND VENDORS 96
miRNA Profiling Technologies and Related Assays 97
TABLE 37 A SAMPLE MICRORNA PROFILING TECHNOLOGIES AND RELATED ASSAYS 97
MICRORNA PROFILING WORKFLOW 98
MICRORNA PROFILING TOOLS FROM LIFE TECHNOLOGIES 98
TaqMan miRNA ABC Purification Kit 98
miRVana miRNA Isolation Kit 98
RecoverAll Total Nucleic Acid Isolation Kit for FFPE 99
Ambion TaqMan microRNA Cells-to-CT Kit 99
MICRORNA PROFILING PRODUCTS FROM EXIQON 100
miRCURY RNA Isolation Kit 100
TABLE 38 MIRCURY RNA ISOLATION KITS OFFERED BY EXIQON 100
miRCURY LNA miRNA Arrays 100
TABLE 39 EXIQON'S MICRORNA MICROARRAY PRODUCTS 101
miRCURY LNA Universal RT miRNA PCR 101
REAGENT KITS FROM EXIQON 101
Universal cDNA Synthesis Kit II 101
TABLE 40 EXIQON'S UNIVERSAL CDNA SYNTHESIS KIT II 102
miRCURY LNA Universal RT microRNA PCR Starter Kit 102
TABLE 41 EXIQON'S MIRCURY LNA UNIVERSAL RT MICRORNA PCR STARTER KIT 102
ExiLENT SYBR Green Master Mix 2.5 mL 102
TABLE 42 EXIQON'S EXILENT SYBR GREEN MASTER MIX 2.5 ML 103
ExiLENT SYBR Green Master Mix 20 mL 103
TABLE 43 EXIQON'S EXILENT SYBR GREEN MASTER MIX 20 ML 103
PRIMER SETS AND PANELS FROM EXIQON 103
miRNA LNA PCR Primer Set 103
Reference Gene Primer Set 104
Predefined microRNA PCR Panels 104
TABLE 44 CONTENTS OF EXIQON'S HUMAN MIRNOME PANEL I AND II, V3 104
TABLE 45 CONTENTS OF EXIQON'S MOUSE, RAT MIRNOME PANEL I AND II, V3 104
TABLE 46 CONTENTS OF EXIQON'S SERUM/PLASMA FOCUS MICRORNA PCR PANEL
V3 105
TABLE 47 CONTENTS OF EXIQON'S CANCER FOCUS MICRORNA PCR PANEL, V3 105
Pick-and-Mix miRNA PCR Panel 105
TABLE 48 CONTENTS OF EXIQON'S PICK-and-MIX MICRORNA PCR PANEL 106
Exiqon's miRCURY LNA microRNA Detection Probes for Northern
Blotting 106
FLUIDIGM'S NUCLEIC ACID PROFILING PRODUCTS 107
C1 Single-Cell Auto Prep IFC 107
Dynamic Array IFC 107
Digital Array IFC 107
Access Array IFC 108
Quantitative Real-Time Digital PCR IFC 108
WAFERGEN'S MICRORNA PROFILING PRODUCTS 108
SmartChip Human miRNA Panel, V3 108
SmartChip Human lncRNA 1 Panel 108
SmartChip Real-Time PCR System 108
QIAGEN'S MICRORNA PROFILING PRODUCTS 109
TABLE 49 QIAGEN'S PRODUCTS FOR MICRORNA PROFILING 109
MICRORNA PROFILING PRODUCTS FROM CBC 110
Geniom RT Analyzer from CBC 110
CBC's microRNA Biomarkers in Cancer 110
MICRORNA PROFILING TOOLS FROM AFFYMETRIX 111
GeneChip miRNA Arrays 111
TABLE 50 AFFYMETRIX' GENECHIP MICRORNA ARRAY PRODUCTS 111
Affymetrix FlashTag Biotin HSR RNA Labeling Kits 112
TABLE 51 AFFYMETRIX FLASHTAG BIOTIN HSR RNA LABELING KIT 112
MICRORNA PROFILING TOOLS FROM GENOSENSOR 112
TABLE 52 GENOSENSOR'S MICRORNA PROFILING TOOLS 112
MICRORNA PROFILING TOOLS FROM AGILENT TECHNOLOGIES 113
Human miRNA Microarrays 113
TABLE 53 AGILENT TECHNOLOGIES' HUMAN MICRORNA MICROARRAYS 113
MICRORNA PROFILING TOOLS FROM LIFE TECHNOLOGIES 113
NCode miRNA Arrays 113
TABLE 54 NCODE HUMAN RNA MICROARRAYS FROM LIFE TECHNOLOGIES 114
NCOUNTER ANALYSIS SYSTEMS FROM NANOSTRING TECHNOLOGIES 114
ONE ARRAY PRODUCTS FROM PHALANX BIOTECH 115
TABLE 55 ONE ARRAY PRODUCTS FROM PHALANX BIOTECH 115
MPARAFLO BIOCHIP ARRAY FROM LC BIOSCIENCES 115
TABLE 56 PARAFLO BIOCHIP ARRAY SERVICES FROM LC BIOSCIENCES 116
SOLID SYSTEM FROM LIFE TECHNOLOGIES 116
GS FLX+ SYSTEM FROM ROCHE 116
MISEQ SYSTEMS FROM ILLUMINA 116
TABLE 57 COMPARISONS OF MISEQ SYSTEMS FROM ILLUMINA 117
HISEQ 2000 FROM ILLUMINA 117
ION TORRENT TECHNOLOGY FROM LIFE TECHNOLOGIES 117
GS JUNIOR FROM ROCHE 117
MARKET LEADING MICRORNA PROFILING TECHNOLOGIES 118
FIGURE 13 MARKET SHARES OF LEADING MICRORNA PROFILING TECHNOLOGIES,
2013 (%) 118
PREDOMINANTLY USED MICRORNA PROFILING TECHNOLOGIES 119
miRNA Isolation Tools 119
TABLE 58 MICRORNA ISOLATION KITS AND VENDORS 119
Most Commonly Used RNA Extraction Kits 119
TABLE 59 MOST COMMONLY USED RNA EXTRACTION KITS 120
Specimen-Specific RNA Kits 120
TABLE 60 COMMONLY USED RNA KITS BY TYPE OF SPECIMEN 121
MICRORNA EXTRACTION PRODUCTS 121
mirVana Kit Family 121
TABLE 61 MIRVANA MICRORNA ISOLATION KIT FAMILY 121
mirPremier miRNA Isolation Kit 122
miRCURY RNA Isolation Kit 122
TABLE 62 EXIQON'S MIRCURY RNA ISOLATION KITS 123
High Pure miRNA Isolation Kit from Roche 123
Favorgen miRNA Isolation Kit 123
RNeasy Mini Kit from Qiagen 123
TABLE 63 RNEASY MINI KIT FROM QIAGEN 124
Arcturus PicoPure RNA Isolation Kit from Life Technologies 124
Absolutely Total miRNA Purification Kits from Agilent Technologies 124
SV Total RNA Isolation Kit from Promega 124
TABLE 64 SV TOTAL RNA ISOLATION KIT FROM PROMEGA 125
RNAqueous Kit from Life Technologies 125
AllPrep DNA/RNA Micro Kit from Qiagen 125
NUCLEIC ACID ISOLATION AND PURIFICATION MARKET 125
FIGURE 14 GLOBAL MARKET FOR NUCLEIC ACID ISOLATION AND PURIFICATION,
2013-2019 ($ BILLIONS) 126
MICRORNA MICROARRAY TOOLS 127
TABLE 65 COMPARISON OF FOUR MICRORNA MICROARRAY PLATFORMS 127
Human miRNA V3 from Agilent 128
TABLE 66 HUMAN MICRORNA V3 MICROARRAYS FROM AGILENT 128
miRCURY LNA miRNA Array from Exiqon 128
TABLE 67 MIRCURY LNA MICRORNA ARRAYS FROM EXICON 129
Human miRNA V2 from Illumina 129
TABLE 68 HUMAN MICRORNA V2 FROM ILLUMINA 130
miRXplore Microarray V5 from Miltenyi 130
TABLE 69 MIRXPLORE MICROARRAYS FROM MILTENYI 130
Global Microarray Market 131
FIGURE 15 GLOBAL MICROARRAY DIAGNOSTIC ANALYSIS MARKET, 2013-2019 ($
BILLIONS) 131
Microarray Tools Market for miRNA Research 132
FIGURE 16 GLOBAL MARKET FOR MICROARRAY TOOLS USED IN MICRORNA
RESEARCH, 2013-2019 ($ MILLIONS) 133
REAL-TIME PCR 133
FIGURE 17 STEPS INVOLVED IN PLANNING RT-QPCR ASSAY 133
RT-qPCR: The Preferred Choice of Researchers 134
Enhanced Features for Traditional PCR 135
Continued Demand for Higher Throughput 136
New Trends in PCR Enzymes 136
Popular qRT-PCR Systems in the Market 136
TABLE 70 SELECTED PCR SYSTEMS AND VENDORS 137
Selected Reagent Suppliers for PCR 138
TABLE 71 SELECTED REAGENT SUPPLIERS FOR PCR 138
Description of Selected Reagents 139
TRIzol Reagent 139
mirVana miRNA Isolation Kit 140
TABLE 72 REAGENTS PROVIDED WITH MIRVANA MIRNA ISOLATION KIT 140
mirVana qRT-PCR miRNA Detection Kit 140
TABLE 73 COMPONENTS OF MIRVANA QRT-PCR MICRORNA DETECTION KIT 141
PureLink miRNA Isolation Kit 141
TABLE 74 COMPONENTS OF PURELINK MICRORNA ISOLATION KIT 141
siPORT NeoFX Transfection Agent 142
miRNA-Specific Stem-Loop Primers 142
TaqMan miRNA Reverse Transcription Kit 142
Early Access TaqMan qRT-PCR miRNA panel 143
NCode miRNA First-Strand cDNA Synthesis Kit 143
Global PCR Market 143
FIGURE 18 GLOBAL MARKET FOR PCR PLATFORMS, 2013-2019 ($ BILLIONS) 144
Global Demand for PCR by End-Use Segment 144
FIGURE 19 GLOBAL DEMAND FOR PCR BY END-USE SEGMENT, 2013-2019 ($
BILLIONS) 145
Patenting Trends in PCR-Based Diagnostics in Cancer 145
TABLE 75 PATENTING TRENDS IN PCR-BASED DIAGNOSTICS FOR CANCER,
1991-2013 (NO. OF HITS) 146
PCR Instruments Market Shares 146
TABLE 76 REAL-TIME PCR MARKET SHARES IN LIFE SCIENCES RESEARCH, 2013 (%) 146
Global Market for qRT-PCR Tools and Reagents in miRNA
Research 147
FIGURE 20 GLOBAL MARKET FOR QRT-PCR TOOLS AND REAGENTS FOR MICRORNA
RESEARCH, 2013-2019 ($ MILLIONS) 147
NEXT-GENERATION SEQUENCING 148
TABLE 77 POPULAR NGS PLATFORMS CURRENTLY AVAILABLE IN THE MARKET 148
Choosing the Right NGS Instrument 148
TABLE 78 COMPARISON OF THE FOUR MAJOR NGS PLATFORMS 149
TABLE 79 COMPARISON OF ALL NGS SYSTEMS 150
Number of NGS Systems and Facilities across the World 156
TABLE 80 NUMBER OF SEQUENCING CENTERS AND NUMBER OF NGS SYSTEMS BY
COUNTRY, AS OF 2013 (NUMBER) 156
Number of NGS Systems by Geographical Region 158
TABLE 81 NUMBER OF NGS SYSTEMS BY REGION, 2013 (NUMBER) 158
NGS Platforms by Number of Centers and Machines 158
TABLE 82 NGS PLATFORMS BY NUMBER OF CENTERS AND MACHINES (NUMBER) 159
Number of NGS Systems in Top Genome Centers around the World 159
TABLE 83 NUMBER OF NGS SYSTEMS IN TOP GENOME CENTERS AROUND THE
WORLD 159
NGS Systems in North American Facilities 164
TABLE 84 TYPES OF NGS SYSTEMS IN SELECTED NORTH AMERICAN FACILITIES 165
Most Cited Concerns in the Purchase of NGS Systems 166
TABLE 85 MOST CITED CONCERNS IN THE PURCHASE OF NGS SYSTEMS (%) 166
NGS Service Providers across the World 167
TABLE 86 LIST OF SELECTED NGS SERVICE PROVIDERS 167
NGS-Focused Publications 169
FIGURE 21 NGS-FOCUSED PUBLICATIONS, 2005-2013 (NUMBER) 169
Selected NGS-Based Tests with Clinical Application 170
TABLE 87 SELECTED NGS-BASED TESTS WITH CLINICAL APPLICATION 170
Utilization of NGS by Type of Research 171
FIGURE 22 APPLICATION SHARES OF NGS BY TYPE OF RESEARCH, 2013 (%) 171
Commercial Reagents and Kits for NGS-Based Research 172
TABLE 88 COMMERCIAL REAGENTS AND KITS FOR NGS-BASED RESEARCH 172
Most Popular NGS Methods 176
FIGURE 23 SHARES OF THE MOST POPULAR NGS METHODS, 2013 (%) 176
Utilization of NGS Platforms by Type of Instrument 177
FIGURE 24 UTILIZATION SHARES OF NGS PLATFORMS BY TYPE OF INSTRUMENT,
2013 (%) 177
Percentage of Utilization of NGS by Type of Study 178
FIGURE 25 SHARE OF PRIMARY SEQUENCING WORK PERFORMED IN
LABORATORIES BY TYPE, 2013 (%) 178
Comparison of NGS with Microarray 179
NGS vs. Microarrays in ChIP Experiments 180
NGS vs. Microarrays in Gene Expression Experiments 180
NGS vs. Microarrays in Genotyping Studies 180
NGS vs. Microarrays in Methylation Projects 180
NGS vs. Microarrays in the Diagnostics Market 181
NGS vs. Microarrays in Cytogenetics 181
Global NGS Market 181
FIGURE 26 GLOBAL NGS MARKET, 2013-2019 ($ BILLIONS) 181
Global NGS Informatics Market 182
FIGURE 27 GLOBAL NGS INFORMATICS MARKET, 2013-2019 ($ MILLIONS) 182
NGS Market Shares by Region 183
FIGURE 28 GLOBAL NGS MARKET SHARES BY GEOGRAPHY, 2013-2019 (%) 183
NGS Platform Market Shares by Company 184
FIGURE 29 NGS PLATFORM MARKET SHARES BY COMPANY, 2013 (%) 185
Breakdown of NGS Market by Area of Research 185
FIGURE 30 BREAKDOWN OF NGS MARKET BY AREA OF RESEARCH, 2013 (%) 186
Cost Comparison of NGS Sequencers 187
TABLE 89 COST COMPARISON OF NEXT-GENERATION SEQUENCERS 187
NGS Sequence Platform Market Outlook in Units 187
FIGURE 31 NGS SEQUENCING PLATFORM MARKET OUTLOOK IN UNITS, 2013-2019
(UNITS) 188
Global NGS Consumables Market 188
FIGURE 32 GLOBAL NGS CONSUMABLES MARKET, 2013-2019 ($ BILLIONS) 189
Global Market for NGS and Functional Assays in miRNA Research 189
FIGURE 33 GLOBAL MARKET FOR NGS AND FUNCTIONAL ASSAYS IN MICRORNA
RESEARCH, 2013-2019 ($ MILLIONS) 190
FLUORESCENCE MICRORNA IN SITU HYBRIDIZATION (MIRNA FISH) 190
FISH Tool from Affymetrix 191
ViewRNA miRNA In Situ Hybridization 191
TABLE 90 VIEWRNA MICRORNA ISH CELL ASSAY PROFILE 192
miRCURY LNA miRNA Detection Probes for In Situ Hybridization from
Exiqon 192
TABLE 91 MIRCURY LNA PRODUCT FAMILY FROM EXIQON 193
Global Market for In Situ Hybridization Assays 193
FIGURE 34 GLOBAL MARKET FOR IN SITU HYBRIDIZATION ASSAYS, 2013-2019 ($
BILLIONS) 193
CHAPTER 9 SUMMARY OF TOOLS AND REAGENTS MARKET IN MICRORNA RESEARCH 196
TABLE 92 GLOBAL MARKET FOR MICRORNA RESEARCH TOOLS, THROUGH 2019 ($
MILLIONS) 196
FIGURE 35 GLOBAL MARKET FOR MICRORNA RESEARCH TOOLS, 2013-2019 ($
MILLIONS) 196
CHAPTER 10 MARKET SUMMARY FOR MICRORNA RESEARCH TOOLS, SERVICES,
DIAGNOSTICS AND DRUG DISCOVERY PRODUCT DEVELOPMENT 199
TABLE 93 GLOBAL MARKET FOR MICRORNA RESEARCH TOOLS, SERVICES,
DIAGNOSTICS AND DRUG DISCOVERY, THROUGH 2019 ($ MILLIONS) 200
FIGURE 36 GLOBAL MARKET FOR MICRORNA RESEARCH TOOLS, SERVICES,
DIAGNOSTICS AND DRUG DISCOVERY, 2013-2019 ($ MILLIONS) 200
SELECTED MICRORNA MARKET PARTICIPANTS 201
TABLE 94 SELECTED MICRORNA MARKET PARTICIPANTS 201
CHAPTER 11 SELECTED COMPANY PROFILES 204
AFFYMETRIX INC. 204
BRIEF HISTORY 204
PRODUCTS 204
AGILENT TECHNOLOGIES INC. 207
BRIEF HISTORY 207
PRODUCTS 207
Human miRNA Microarrays 207
TABLE 95 AGILENT'S HUMAN MICRORNA MICROARRAYS 208
Agilent's Custom miRNA Microarrays 208
TABLE 96 AGILENT'S CUSTOM MICRORNA MICROARRAYS 208
Agilent's Universal Reference RNAs 208
TABLE 97 AGILENT'S UNIVERSAL REFERENCE RNAS 209
Agilent's miRNA Complete Labeling and Hybridization Kit 209
TABLE 98 AGILENTS MICRORNA COMPLETE LABELING AND HYBRIDIZATION KIT 209
ALNYLAM PHARMACEUTICALS INC. 209
BRIEF HISTORY 209
PRODUCT PIPELINE 210
Alnylam 5x15 210
TABLE 99 ALNYLAM 5 X 15 DEVELOPMENT PIPELINE 211
AMBION INC. (LIFE TECHNOLOGIES) 211
BRIEF HISTORY 211
PRODUCTS 212
TABLE 100 MICRORNA FROM AMBION 212
APPLIED BIOLOGICAL MATERIALS (ABM) INC. 212
BRIEF HISTORY 212
PRODUCTS 213
ASURAGEN INC. 214
BRIEF HISTORY 214
PRODUCTS 214
miRNA Services 214
miRNA Sequencing 215
miRInform Thyroid 215
BIOFIRE DIAGNOSTICS INC. 215
BRIEF HISTORY 215
PRODUCTS 216
FilmArray Multiplex PCR 216
BIO-RAD LABORATORIES INC. 216
BRIEF HISTORY 216
PRODUCTS 217
QX 200 Droplet Digital PCR System 217
CFX96 Touch Real-Time PCR Detection System 217
CSF384 Touch Real-Time PCR Detection System 217
CFX Connect Real-Time PCR Detection System 217
CFX96 Touch Deep Well Real-Time PCR Detection System 217
CBC (COMPREHENSIVE BIOMARKER CENTER) 218
BRIEF HISTORY 218
PRODUCTS 218
RNA Extraction Services 218
miRNA Profiling Services 218
miRNA Microarray Profiling Services 219
EXIQON A/S 219
BRIEF HISTORY 219
PRODUCTS AND SERVICES 220
miRCURY RNA Isolation Kits 220
TABLE 101 MIRCURY RNA ISOLATION KITS FROM EXIQON 220
miRCURY LNA miRNA Power Labeling Kits 220
TABLE 102 MIRCURY LNA MICRORNA POWER LABELING KITS FROM EXIQON 220
miRCURY LNA miRNA Arrays 221
TABLE 103 MIRCURY LNA MICRORNA ARRAYS 221
miRCURY LNA Universal RT microRNA PCR 222
TABLE 104 MIRCURY LNA UNIVERSAL RT MICRORNA PCR FROM EXICON 223
miRCURY LNA microRNA Detection Probes for Northern Blotting 224
TABLE 105 MIRCURY LNA MICRORNA DETECTION PROBES FOR NORTHERN
BLOTTING FROM EXICON 224
miRCURY LNA microRNA Detection Probes for In Situ Hybridization 225
TABLE 106 MIRCURY LNA MICRORNA DETECTION PROBES FOR IN SITU
HYBRIDIZATION FROM EXIQON 225
miRCURY LNA miRNA Inhibitors and Power Inhibitors 226
TABLE 107 MIRCURY LNA MICRORNA INHIBITORS AND POWER INHIBITORS 226
miRCURY LNA miRNA Inhibitor Libraries 226
TABLE 108 MIRCURY LNA MICRORNA INHIBITOR LIBRARIES FROM EXIQON 227
EXIQON'S STRONG PIPELINE OF MIRNA DIAGNOSTICS 227
TABLE 109 EXIQON'S STRONG PIPELINE OF MICRORNA DIAGNOSTICS 227
EXIQON'S REVENUE HISTORY 227
TABLE 110 EXIQON'S REVENUES, 2009-2013 (DKK THOUSAND) 227
FIGURE 37 COMPARISON OF EXIQON'S SEGMENTAL REVENUE SHARES, 2012 AND
2013 (%) 228
FIREFLY BIOWORKS INC. 229
FLUIDIGM CORP. 230
GENECOPOEIA INC. 232
TABLE 111 COMPARISON OF VECTOR-BASED INHIBITORS AND SYNTHESIZED
MICRORNA INHIBITORS 233
Mechanism of Action 234
All-in-One miRNA qRT-PCR Reagent Kits and Validated Primers 234
miRNA Lentivirus 234
GENOSENSOR CORP. 235
GENSIGNIA LIFE SCIENCES INC. 236
GROOVE BIOPHARMA CORP. 237
HTG MOLECULAR DIAGNOSTICS INC. 237
ILLUMINA INC. 240
ILLUMINA'S SERVICES 242
INTEGRATED DNA TECHNOLOGIES INC. 242
INTERNA TECHNOLOGIES BV 243
ISIS PHARMACEUTICALS INC. 244
TABLE 113 ISIS PHARMACEUTICALS' PIPELINE 245
LC SCIENCES LLC 247
LIFE TECHNOLOGIES CORP. 249
MILTENYI BIOTEC 251
MIRAGEN THERAPEUTICS INC. 253
TABLE 115 MIRAGEN'S PIPELINE PRODUCTS 254
MIRNA THERAPEUTICS INC. 256
TABLE 116 MIRNA'S PIPELINE 256
MIRUS BIO LLC 257
NANOSTRING TECHNOLOGIES INC. 257
ORIGENE TECHNOLOGIES INC. 260
PACIFIC BIOSCIENCES OF CALIFORNIA INC. 262
PHALANX BIOTECH GROUP INC. 263
PROLIAS TECHNOLOGIES 264
QIAGEN NV 265
REGULUS THERAPEUTICS INC. 266
TABLE 118 REGULUS' CLINICAL MAP INITIATIVE 267
TABLE 119 REGULUS' INITIAL MICRORNA DEVELOPMENT PROGRAMS 268
ROCHE HOLDING AG 268
ROSETTA GENOMICS LTD. 270
TABLE 120 ROSETTA'S PIPELINE: ROSETTA'S PROPRIETARY TESTS, 2013-2017 271
FIGURE 38 ACTUAL AND PROJECTED REVENUES FOR ROSETTA, 2011-2020 ($
MILLIONS) 272
SANTARIS PHARMA A/S 272
TABLE 121 PRODUCT PIPELINE FROM SANTARIS PHARMA 273
SAREPTA THERAPEUTICS INC. 273
TABLE 122 SAREPTA THERAPEUTICS' PIPELINE 274
THERADIAG SA 275
THERMO FISHER SCIENTIFIC INC. 276
WAFERGEN BIOSYSTEMS INC. 277
WAKO PURE CHEMICAL INDUSTRIES LTD. 280
CHAPTER 12 APPENDIX: ACRONYMS AND ABBREVIATIONS 283
TABLE 123 ACRONYMS AND ABBREVIATIONS 283

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