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Photomedicine: Technologies and Global Markets

  • September 2014
  • -
  • BCC Research
  • -
  • 141 pages

This BCC Research study provides a comprehensive analysis of the market of photomedicine. It addresses the drivers and limiters of the market and offers an exhaustive analysis of both drugs and medical devices for use in this industry. The photomedicine global market is analyzed and historical sales of drugs and medical devices used in photomedicine are included for 2013 and estimates provided for 2014. Revenue forecasts are also included through 2019.

Use this report to:
- Understand the pharmaceutical and medical device markets in photomedicine, as well as the need for innovation and new marketing strategies.
- Receive in-depth market analysis, with segmentation by region, by products and type of products, by therapeutic areas and by type of treatment.
- Focus on the drugs activated by light, ultraviolet phototherapy, photodynamic therapy (PDT), and low-level laser light therapy.
- Learn about the major products that generate the largest revenues, as well as the most-valuable R&D products.

Highlights
- The global market of photomedicine, including drugs and devices, was valued at $609.7 million in 2013. The market is expected to reach $616.8 million in 2014 and $754 million in 2019, a compound annual growth rate (CAGR) of 4.1% for the five-year period, 2014 to 2019.
- North America holds the most market share and is expected to increase from $300.9 million in 2014 to $372 million in 2019, a CAGR of 4.3% from 2014 to 2019.
- The European region is expected to reach $198.6 million in 2014 and $238.8 million in 2019, a CAGR of 3.8% from 2014 to 2019.

Introduction & Scope

INTRODUCTION

STUDY GOALS AND OBJECTIVES
This study provides a comprehensive analysis of the market of photomedicine. Photomedicine is comprehensive of both therapeutics activated by light, as well as light emitting medical devices such as UV lamps and some lasers. In particular, this study will focus on drugs activated by light, ultraviolet phototherapy, photodynamic therapy (PDT), and low-level laser light therapy. Surgical lasers will be excluded from this report.

Phototherapy has been used to treat psoriasis for the past 100 years, and, in the opinion of many experts, it remains underutilized because of a decline in health insurance reimbursements and the increase in price of UV light therapy. The market is mature but not saturated. To overcome the threats posed by competitive treatments, this market requires innovation, new marketing tactics, strategic alliances, and innovative business models. This report addresses the drivers and limiters of the market and offers an exhaustive analysis of both drugs and medical devices for use in photomedicine.

REASON FOR DOING THE STUDY
Some of the health conditions discussed in the report have very few approved treatments; in some cases, photomedicine is the only available option to the patients.
However, due to the rapid transformations occurring in research and development, new healthcare reforms, and the advent of personalized medicine, the dynamics of the
market are changing. The report analyzes the global market and includes historical sales of drugs and medical devices used in photomedicine in 2013 and estimates for
2014. Sales are forecast through 2019. This study in an invaluable instrument for understanding the pharmaceutical and medical device markets in photomedicine, as well as the need for innovation and new marketing strategies. The market is characterized by the creation of partnerships, collaborations and mergers and acquisitions (M&A) between pharmaceutical companies and the medical device industries.

SCOPE OF THE REPORT
The global market of photomedicine will grow to about $754 million by 2019 at a compound annual growth rate of 4.1% from 2014 to 2019. This report provides a detailed segmentation by region, by products and type of products, by therapeutic areas and by type of treatment. Profiles of key market players are also included. Major products that generate the largest revenues, as well as the most-valuable R&D products that will come on the market up to 2019 are provided.

In-depth competitive market analysis is discussed, with examples of how new products will enter the market or how existing products will survive or perish. The report also
includes descriptions of current and future technologies for drugs and devices used in photomedicine. In the future, nanotechnology will play a pivotal role in drug and
discovery innovation.

Table Of Contents

Photomedicine: Technologies and Global Markets
TABLE OF CONTENTS
CHAPTER 1 INTRODUCTION 2
STUDY GOALS AND OBJECTIVES 2
REASON FOR DOING THE STUDY 2
SCOPE OF THE REPORT 2
INTENDED AUDIENCE 3
METHODOLOGY AND INFORMATION SOURCE 3
ANALYST'S CREDENTIALS 3
RELATED BCC RESEARCH REPORTS 4
BCC RESEARCH WEBSITE 4
DISCLAIMER 4
CHAPTER 2 SUMMARY 6
SUMMARY TABLE GLOBAL MARKET FOR PHOTOMEDICINE BY REGION, THROUGH
2019 ($ MILLIONS) 7
SUMMARY FIGURE GLOBAL MARKET FOR PHOTOMEDICINE BY REGION, 2013-2019
($ MILLIONS) 7
CHAPTER 3 OVERVIEW 9
TABLE 1 EXAMPLES OF DRUGS AND MEDICAL DEVICES MARKETED AS A COMBO IN
PHOTOMEDICINE 9
HISTORY OF PHOTOMEDICINE 10
EARLY HISTORY OF PHOTOMEDICINE 10
DISCOVERY OF INVOLVEMENT OF LIGHT IN HUMAN DISEASES 10
DEVELOPMENT OF PHOTOTHERAPY (HELIOTHERAPY) IN CLINICAL
APPLICATIONS 11
DISCOVERY OF PHOTODYNAMIC THERAPY 12
DEVELOPMENT OF LASER BASED THERAPIES 13
DEVELOPMENT OF ULTRA-VIOLET LIGHT THERAPIES 13
PRESENT STATUS OF PHOTOMEDICINE 14
NEW AND FUTURE APPLICATIONS OF PHOTOMEDICINE AND PHOTODYNAMIC
THERAPY 14
DEVELOPMENT OF IMPROVED PHOTOSENSITIZERS 14
IMPROVING LIGHT EXCITATION PROCEDURES 16
Applications in Oncology 17
Advances in Antibacterial Applications 17
Other General Applications 18
CHAPTER 4 GLOBAL PHOTOMEDICINE MARKET 21
MARKET FOR PHOTOMEDICINE 21
TABLE 2 GLOBAL MARKET FOR PHOTOMEDICINE BY REGION, THROUGH 2019 ($
MILLIONS) 21
TABLE 3 GLOBAL MARKET SHARE FOR PHOTOMEDICINE BY REGION, 2013-2019 (%) 21
FIGURE 1 GLOBAL MARKET SHARE FOR PHOTOMEDICINE BY REGION, 2014 (%) 21
MARKET FOR DRUGS IN PHOTOMEDICINE 22
TABLE 4 GLOBAL MARKET FOR DRUGS IN PHOTOMEDICINE, THROUGH 2019 ($
MILLIONS) 22
TABLE 5 GLOBAL MARKET FOR DRUGS IN PHOTOMEDICINE BY REGION, THROUGH
2019 ($ MILLIONS) 23
TABLE 6 GLOBAL MARKET SHARE FOR DRUGS IN PHOTOMEDICINE BY
THERAPEUTIC AREA, 2014 AND 2019 (%) 23
FIGURE 2 GLOBAL MARKET SHARE FOR DRUGS IN PHOTOMEDICINE BY
THERAPEUTIC AREA, 2014 AND 2019 (%) 23
TABLE 7 GLOBAL MARKET FOR DRUGS IN PHOTOMEDICINE BY CHEMICAL
SPECIALTY, THROUGH 2019 ($ MILLIONS) 24
TREATMENT MARKET IN PHOTOMEDICINE 25
TABLE 8 GLOBAL MARKET FOR PHOTOMEDICINE, BY TREATMENT, THROUGH 2019
($ MILLIONS) 25
TABLE 9 GLOBAL MARKET SHARE FOR PHOTOMEDICINE BY TREATMENT,
2013-2019 (%) 25
FIGURE 3 GLOBAL MARKET SHARE FOR PHOTOMEDICINE BY TREATMENT, 2014 (%) 25
TABLE 10 GLOBAL MARKET FOR PUVA THERAPY BY REGION, THROUGH 2019 ($
MILLIONS) 26
TABLE 11 GLOBAL MARKET FOR UVB THERAPY BY REGION, THROUGH 2019 ($
MILLIONS) 27
TABLE 12 GLOBAL MARKET FOR LLLT IN PHOTOMEDICINE BY REGION, THROUGH
2019 ($ MILLIONS) 27
TABLE 13 GLOBAL MARKET FOR PHOTODYNAMIC THERAPY, THROUGH 2019 ($
MILLIONS) 27
TABLE 14 GLOBAL MARKET FOR PHOTODYNAMIC THERAPY BY REGION, THROUGH
2019 ($ MILLIONS) 28
TABLE 15 GLOBAL MARKET FOR PHOTODYNAMIC THERAPY LASERS FOR CANCER
BY REGION, THROUGH 2019 ($ MILLIONS) 28
CHAPTER 5 LIGHT 30
ULTRAVIOLET RADIATION 30
ARTIFICIAL SOURCES OF UV LIGHT 30
Black lights 30
Short-wave UV Lamps 30
Gas-discharge Lamps 30
Ultraviolet Light-emitting Diodes (LEDs) 31
Ultraviolet Lasers 31
TABLE 16 ULTRAVIOLET RADIATION CLASSIFICATION BY NAME, WAVELENGTH AND
ENERGY 31
VISIBLE LIGHT 31
TABLE 17 VISIBLE SPECTRUM BY COLOR, WAVELENGTH AND ENERGY 32
CHAPTER 6 PHOTOPROTECTION 34
SKIN 34
UV RADIATION EFFECTS ON SKIN 34
TABLE 18 DISEASES SOMETIMES AGGRAVATED BY UV IRRADIATION 34
PHOTOPROTECTION 35
UV FILTERS 35
TABLE 19 UV FILTER BY TYPE 35
Organic UV Absorbers 35
UVB Filters 36
UVA Filters 36
Broad-Spectrum UVB and UVA Filters 37
Organic Particulates 37
Inorganic Particulates 38
TABLE 20 CHEMICAL COMPOUNDS USED AS PHOTOPROTECTOR 38
CHAPTER 7 PHOTOTHERAPY: HEALTH CONDITIONS AND TREATMENTS 40
UVB THERAPY 40
MANAGEMENT OF PSORIASIS USING UVB 40
PRINCIPLES INVOLVED IN THE MANAGEMENT OF PSORIASIS USING UVB 40
LASER THERAPY 41
ADDITIONAL TREATMENT OPTIONS 41
THE USE OF UVB THERAPY FOR THE TREATMENT OF OTHER DISORDERS 41
PUVA THERAPY 42
MECHANISM OF ACTION OF PUVA 42
THERAPEUTIC RESULTS 42
REPUVA 43
EXTRACORPOREAL PHOTOPHERESIS (ECP) 43
USE OF ULTRAVIOLET C (UVC) FOR THE TREATMENT OF INFECTIONS 44
MECHANISM OF ACTION OF UVC 45
ULTRAVIOLET BLOOD IRRADIATION 45
TABLE 21 ADVANTAGES OF USING UBI THERAPY 46
PHOTODYNAMIC THERAPY (PDT) 46
INTRODUCTION 46
TABLE 22 PHOTODYNAMIC THERAPY PROS AND CONS 50
USE OF CLINICAL PDT IN CHINA 50
ALA 51
Hemoporfin 51
Deuteporfin 51
Suftalan Zinc 51
Radion 52
Sources of Light 52
PDT IN RUSSIA 52
TABLE 23 PHOTOSENSITIZERS FOR PDT DEVELOPED IN RUSSIA 53
LOW-LEVEL LASER LIGHT THERAPY (LLLT) 54
BIOCHEMICAL MECHANISMS 55
ACTION SPECTRA 55
WOUND HEALING 56
WAVELENGTH 57
LASER VS. NON-COHERENT LIGHT 57
PULSED OR CW 57
POLARIZATION STATUS 58
SYSTEMIC EFFECTS 58
SURGICAL LASER THERAPY 58
INTRODUCTION 58
HAIR REMOVAL 58
WRINKLE TREATMENT 59
DENTAL TREATMENTS 59
EYE SURGERY 59
OTHER MEDICAL USES 60
PRACTITIONERS 60
BIOSTIMULATION LASERS 60
LASER RADIATION SAFETY 60
DRUGS USED IN PHOTOTHERAPY 61
TABLE 24 DRUGS USED IN PHOTOTHERAPY BY TYPE OF CHEMICAL COMPOUND 61
APTOCINE 61
FOSCAN 62
PHOTOCHLORIN 62
PHOTOFRIN 62
VISUDYNE 62
ALLUMERA 63
HEXVIX 63
LEVULAN 64
METVIXIA 64
PSORALEN 64
ANTHRALIN 64
VISONAC 65
LUMACAN 65
CALCIPOTRIENE 66
DEVICES USED IN PHOTOTHERAPY 66
XTRACT 66
LEVIA 67
UVA LAMPS 68
TABLE 25 EXAMPLE OF DRUGS AND MEDICAL DEVICES MARKETED AS A COMBO IN
PHOTOMEDICINE 68
TABLE 26 KEY MARKET PLAYERS IN PHOTOTHERAPY BY COMPANY AND PRODUCT 69
TABLE 27 KEY MARKET PLAYERS IN PHOTOTHERAPY, PRODUCTS PIPELINE 69
PSORIASIS 69
TABLE 28 PSORIASIS INCIDENCE BY COUNTRY IN 2011 70
TABLE 29 PSORALEN BRAND NAMES BY COMPANY AND BY COUNTRY 71
CHAPTER 8 NANOTECHNOLOGY IN PHOTOMEDICINE 73
CANCER PHOTOTHERMAL THERAPY 73
FULLERENE C60 73
C60 TOXICITY 74
UPTAKE AND BIODISTRIBUTION 74
PHOTODYANIMC THERAPY 74
GOLD NANOPARTICLES 75
CONTRAST ENHANCERS 75
Polymer-Based Imaging Probes for Cancer Imaging 76
QUANTUM DOTS IN CANCER IMAGING AND THERAPY 77
QUANTUM DOTS IN PHOTODYNAMIC THERAPY AND IMAGING 77
MULTIFUNCTIONAL MAGNETIC NANOPARTICLES FOR CANCER IMAGING AND
THERAPY 77
GOLD NANOMATERIALS FOR PHOTOTHERMAL THERAPY 78
CHAPTER 9 DRIVERS AND RESTRAINTS 80
TABLE 30 BIOLOGICS APPROVED FOR PSORIASIS 80
TABLE 31 DRIVERS FOR THE PHOTOMEDICINE MARKET 81
TABLE 32 LIMITERS FOR THE PHOTOMEDICINE MARKET 82
COMPARISON BETWEEN PHOTOTHERAPY AND ORAL MEDICATIONS 82
TABLE 33 COST OF PSORIASIS FOR A TYPICAL WESTERN EUROPEAN COUNTRY 83
CHAPTER 10 PATENT ANALYSIS 85
TABLE 34 PATENTS IN PHOTOTHERAPY BY YEAR, 2003-2013 (NUMBER) 85
FIGURE 4 PATENTS IN PHOTOTHERAPY BY YEAR. 2003-2013 (NUMBER) 85
TABLE 35 PATENTS IN PHOTODYNAMIC THERAPY BY YEAR, 2003-2013 (NUMBER) 86
FIGURE 5 PATENTS ABOUT PHOTODYNAMIC THERAPY BY YEAR, 2003-2013
(NUMBER) 86
CHAPTER 11 HEALTHCARE SYSTEMS IN THE WORLD 88
EUROPE 88
BELGIUM 88
SWEDEN 89
NORTH AMERICA 89
SOUTH AMERICA 90
ASIA 90
CHINA 90
INDIA 91
AFRICA 91
TABLE 36 WORLD HEALTH ORGANIZATION HEALTHCARE RANKING, 2000 92
TABLE 37 EURO HEALTH CONSUMER INDEX HEALTHCARE RANKING IN EUROPE,
2013 93
TABLE 38 BLOOMBERG HEALTHCARE RANKING, 2013 94
CHAPTER 12 PRESS RELEASES 97
TABLE 39 RELEVANT PRESS RELEASES IN PHOTOMEDICINE 97
CHAPTER 13 PROFILES OF COMPANIES 122
ABBOTT MEDICAL OPTICS 122
ABBVIE 122
AESCULIGHT 122
AGENUS 123
AICURIS 123
ALCON 123
ALLERGAN 124
ALMIRALL 124
AMGEN 124
AMJO 125
ANACOR 125
ANGES 125
ANGIODYNAMICS 126
APEIRON 126
ASTELLAS 126
ASTION 127
ASTRAZENECA 127
ASUKA LASER SYSTEMS 127
BARRIER THERAPEUTICS 128
BASILEA 128
BELMEDPREPARATY 128
BIOLASE TECHNOLOGY 129
BIOLITEC 129
BRISTOL-MYERS SQUIBB 129
CANDELA 130
CELGENE 130
CIPHER PHARMACEUTICALS 130
COHERENT 131
CONVERGENT LASER TECHNOLOGIES 131
CYNOSURE 131
DB PHARMA 132
DEKA LASER 132
DENFOTEX LIGHT SYSTEMS 133
DORNIER MEDTECH GMBH 133
DUSA PHARMACEUTICALS 133
ELI LILLY 134
ELLEX MEDICAL LASERS 134
ERCHONIA MEDICAL 134
FRANCO-INDIAN PHARMACEUTICALS 135
GALDERMA 135
GENENTECH 135
GLAXOSMITHKLINE 136
HANALL BIOPHARMA 136
HEIDELBERG ENGINEERING 136
IMMUNE TECHNOLOGIES and MEDICINE 137
INCYTE 137
INGA LABORATORIES 137
IRIDEX 138
JANSSEN BIOTECH 138
KAKEN PHARMACEUTICALS 138
KELA 139
LANTIS LASER 139
LEO 139
LISA LASER PRODUCTS 140
LIGHT SCIENCES ONCOLOGY 140
LUMENIS 140
MEDA 141
NANOBIO 141
NATIONAL BIOLOGICAL 141
NAVIDEA 142
NIDEK COMPANY 142
NITRIC BIOTHERAPEUTICS 143
NOVARTIS 143
ONDINE BIOPHARMA 143
OPTOS 144
PARALLAX TECHNOLOGY 144
PFIZER 144
PHILIPS 145
PHOTOCURE 145
PHOTOMEDEX 146
PINNACLE BIOLOGICS 146
PLC SYSTEMS 147
QUANTEL MEDICAL 147
RADAPHARMA 147
REGENERON 148
SHANGHAI FUDAN-ZHANGJIAN BIO-PHARMACEUTICAL 148
SOLARC SYSTEMS 149
SOLTA MEDICAL 149
SPECTRANETICS 149
STEBA BIOTECH 150
SWITCH BIOTECH 150
THERAKOS 151
TRIA BEAUTY 151
TRIMEDYNE 151
UCLA HEALTH 152
UVBIOTEK 152
VALEANT PHARMACEUTICALS 152
VASCULAR SOLUTIONS 153
VERILUX 153
VETA GRAND 153
WORLD OF MEDICINE 154
ZEISS MEDITEC 154

LIST OF TABLES

SUMMARY TABLE GLOBAL MARKET FOR PHOTOMEDICINE BY REGION, THROUGH
2019 ($ MILLIONS) 7
TABLE 1 EXAMPLES OF DRUGS AND MEDICAL DEVICES MARKETED AS A COMBO IN
PHOTOMEDICINE 9
TABLE 2 GLOBAL MARKET FOR PHOTOMEDICINE BY REGION, THROUGH 2019 ($
MILLIONS) 21
TABLE 3 GLOBAL MARKET SHARE FOR PHOTOMEDICINE BY REGION, 2013-2019 (%) 21
TABLE 4 GLOBAL MARKET FOR DRUGS IN PHOTOMEDICINE, THROUGH 2019 ($
MILLIONS) 22
TABLE 5 GLOBAL MARKET FOR DRUGS IN PHOTOMEDICINE BY REGION, THROUGH
2019 ($ MILLIONS) 23
TABLE 6 GLOBAL MARKET SHARE FOR DRUGS IN PHOTOMEDICINE BY THERAPEUTIC
AREA, 2014 AND 2019 (%) 23
TABLE 7 GLOBAL MARKET FOR DRUGS IN PHOTOMEDICINE BY CHEMICAL SPECIALTY,
THROUGH 2019 ($ MILLIONS) 24
TABLE 8 GLOBAL MARKET FOR PHOTOMEDICINE, BY TREATMENT, THROUGH 2019 ($
MILLIONS) 25
TABLE 9 GLOBAL MARKET SHARE FOR PHOTOMEDICINE BY TREATMENT, 2013-2019
(%) 25
TABLE 10 GLOBAL MARKET FOR PUVA THERAPY BY REGION, THROUGH 2019 ($
MILLIONS) 26
TABLE 11 GLOBAL MARKET FOR UVB THERAPY BY REGION, THROUGH 2019 ($
MILLIONS) 27
TABLE 12 GLOBAL MARKET FOR LLLT IN PHOTOMEDICINE BY REGION, THROUGH
2019 ($ MILLIONS) 27
TABLE 13 GLOBAL MARKET FOR PHOTODYNAMIC THERAPY, THROUGH 2019 ($
MILLIONS) 27
TABLE 14 GLOBAL MARKET FOR PHOTODYNAMIC THERAPY BY REGION, THROUGH
2019 ($ MILLIONS) 28
TABLE 15 GLOBAL MARKET FOR PHOTODYNAMIC THERAPY LASERS FOR CANCER BY
REGION, THROUGH 2019 ($ MILLIONS) 28
TABLE 16 ULTRAVIOLET RADIATION CLASSIFICATION BY NAME, WAVELENGTH AND
ENERGY 31
TABLE 17 VISIBLE SPECTRUM BY COLOR, WAVELENGTH AND ENERGY 32
TABLE 18 DISEASES SOMETIMES AGGRAVATED BY UV IRRADIATION 34
TABLE 19 UV FILTER BY TYPE 35
TABLE 20 CHEMICAL COMPOUNDS USED AS PHOTOPROTECTOR 38
TABLE 21 ADVANTAGES OF USING UBI THERAPY 46
TABLE 22 PHOTODYNAMIC THERAPY PROS AND CONS 50
TABLE 23 PHOTOSENSITIZERS FOR PDT DEVELOPED IN RUSSIA 53
TABLE 24 DRUGS USED IN PHOTOTHERAPY BY TYPE OF CHEMICAL COMPOUND 61
TABLE 25 EXAMPLE OF DRUGS AND MEDICAL DEVICES MARKETED AS A COMBO IN
PHOTOMEDICINE 68
TABLE 26 KEY MARKET PLAYERS IN PHOTOTHERAPY BY COMPANY AND PRODUCT 69
TABLE 27 KEY MARKET PLAYERS IN PHOTOTHERAPY, PRODUCTS PIPELINE 69
TABLE 28 PSORIASIS INCIDENCE BY COUNTRY IN 2011 70
TABLE 29 PSORALEN BRAND NAMES BY COMPANY AND BY COUNTRY 71
TABLE 30 BIOLOGICS APPROVED FOR PSORIASIS 80
TABLE 31 DRIVERS FOR THE PHOTOMEDICINE MARKET 81
TABLE 32 LIMITERS FOR THE PHOTOMEDICINE MARKET 82
TABLE 33 COST OF PSORIASIS FOR A TYPICAL WESTERN EUROPEAN COUNTRY 83
TABLE 34 PATENTS IN PHOTOTHERAPY BY YEAR, 2003-2013 (NUMBER) 85
TABLE 35 PATENTS IN PHOTODYNAMIC THERAPY BY YEAR, 2003-2013 (NUMBER) 86
TABLE 36 WORLD HEALTH ORGANIZATION HEALTHCARE RANKING, 2000 92
TABLE 37 EURO HEALTH CONSUMER INDEX HEALTHCARE RANKING IN EUROPE,
2013 93
TABLE 38 BLOOMBERG HEALTHCARE RANKING, 2013 94
TABLE 39 RELEVANT PRESS RELEASES IN PHOTOMEDICINE 97

LIST OF FIGURES

SUMMARY FIGURE GLOBAL MARKET FOR PHOTOMEDICINE BY REGION, 2013-2019 ($
MILLIONS) 7
FIGURE 1 GLOBAL MARKET SHARE FOR PHOTOMEDICINE BY REGION, 2014 (%) 21
FIGURE 2 GLOBAL MARKET SHARE FOR DRUGS IN PHOTOMEDICINE BY
THERAPEUTIC AREA, 2014 AND 2019 (%) 23
FIGURE 3 GLOBAL MARKET SHARE FOR PHOTOMEDICINE BY TREATMENT, 2014 (%) 25
FIGURE 4 PATENTS IN PHOTOTHERAPY BY YEAR. 2003-2013 (NUMBER) 85
FIGURE 5 PATENTS ABOUT PHOTODYNAMIC THERAPY BY YEAR, 2003-2013 (NUMBER) 86

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