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Symbicort (Asthma) - Forecast and Market Analysis to 2023

Summary

GlobalData has released its new PharmaPoint Drug Evaluation report, “Symbicort (Asthma) - Forecast and Market Analysis to 2023”. The asthma market saw very slow growth over the past decade, as it has become saturated with relatively efficacious standard therapies, such as short-acting beta-agonists (SABAs), inhaled corticosteroids (ICSs), inhaled corticosteroids and long-acting beta-agonists (ICS/LABAs), and leukotriene modifiers, and has also been facing increasing generic competition. However, the launch of seven novel targeted biologic agents and once-daily ICS and ICS/LABA therapies delivered by the next-generation inhalers will strongly drive the market growth over the next 10 years. The biologic agents will not only reshape the market growth, but will also mark the beginning of a new era of a personalized approach to asthma treatment. The realization that asthma is a very heterogeneous disease is highly reflected in the rich assortment of these targeted therapies in the late-stage pipeline.

Symbicort is an FDC of budenoside and formoterol fumarate developed by AstraZeneca. Budesonide is a synthetic corticosteroid with strong anti-inflammatory activity. It can bind to glucocorticoid receptors with high affinity and inhibit the secretion of mediators involved in asthma. Budesonide is marketed by AstraZeneca as a standalone product called Symbicort. Formoterol fumarate is a highly selective LABA. It acts by increasing cAMP, which, in turn, leads to relaxation of the bronchial smooth muscle.

Scope

- Overview of Asthma, including epidemiology, etiology, symptoms, diagnosis, pathology and treatment guidelines as well as an overview on the competitive landscape.
- Detailed information on Symbicort including product description, safety and efficacy profiles as well as a SWOT analysis.
- Sales forecast for Symbicort for the top eight countries from 2013 to 2023.
- Sales information covered for the US, France, Germany, Italy, Spain, the UK, Japan and Australia.

Reasons to buy

- Understand and capitalize by identifying products that are most likely to ensure a robust return
- Stay ahead of the competition by understanding the changing competitive landscape for Asthma
- Effectively plan your M&A and partnership strategies by identifying drugs with the most promising sales potential
- Make more informed business decisions from insightful and in-depth analysis of Symbicort performance
- Obtain sales forecast for Symbicort from 2013-2023 in top eight countries (the US, France, Germany, Italy, Spain, the UK, Japan and Australia)

Table Of Contents

Symbicort (Asthma) - Forecast and Market Analysis to 2023
1 Table of Contents

2 Introduction 9
2.1 Catalyst 9
2.2 Related Reports 9
2.3 Upcoming Related Reports 11
3 Disease Overview 12
3.1 Etiology and Pathophysiology 12
3.1.1 Etiology 12
3.1.2 Pathophysiology 14
3.1.3 Prognosis 16
3.1.4 Quality of Life 16
3.2 Symptoms 17
4 Disease Management 18
4.1 Diagnosis and Treatment Overview 18
4.1.1 Diagnosis 18
4.1.2 Treatment Guidelines, Clinical Practice, and Leading Prescribed Drugs 19
4.1.3 Clinical Practice 21
5 Competitive Assessment 26
5.1 Overview 26
5.2 Strategic Competitor Assessment 28
6 Symbicort (budenoside/formoterol fumarate) 32
6.1 Overview 32
6.2 Efficacy 34
6.3 Safety 34
6.4 SWOT Analysis 35
6.5 Forecast 36
7 Appendix 37
7.1 Bibliography 37
7.2 Abbreviations 40
7.3 Methodology 43
7.4 Forecasting Methodology 43
7.4.1 Diagnosed Asthma Patients 43
7.4.2 Percent Drug-Treated Patients 44
7.4.3 General Pricing Assumptions 44
7.4.4 Individual Drug Assumptions 45
7.4.5 Generic Erosion 45
7.5 Physicians and Specialists Included in This Study 46
7.6 About the Authors 49
7.6.1 Author 49
7.6.2 Author/Reviewer 49
7.6.3 Reviewer 50
7.6.4 Global Head of Healthcare 50
7.7 About GlobalData 51
7.8 Disclaimer 51

1.1 List of Tables

Table 1: Symptoms of Asthma 17
Table 2: Treatment Guidelines for Asthma by Country 19
Table 3: Most Prescribed Drugs for Asthma by Class and Disease Severity in the Global Markets, 2013 20
Table 4: Dosing of Common ICSs for Adult Asthma Therapy to Achieve Equivalent Therapeutic Potency 23
Table 5: Recommended Low Daily Dose of ICSs in Children with Asthma Under Five Years of Age 25
Table 6: Leading Treatments for Asthma, 2014 31
Table 7: Product Profile - Symbicort 33
Table 8: Efficacy - Symbicort Versus Its Individual Components 34
Table 9: Symbicort, Frequency of Drug-Related Adverse Events 34
Table 10: Symbicort SWOT Analysis, 2014 35
Table 11: Global Sales Forecast ($) for Symbicort, 2013-2023 36
Table 12: High-Prescribing Physicians (non-KOLs) Surveyed, By Country 48

1.2 List of Figures

Figure 1:Stepwise Disease Management Approach for Asthma in Adults 22
Figure 2: Stepwise Disease Management Approach for Asthma in Children Age Five and Younger 24

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