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Lebrikizumab (Asthma) - Forecast and Market Analysis to 2023

  • August 2014
  • -
  • GlobalData
  • -
  • 66 pages

Summary

Table of Contents

Lebrikizumab (Asthma) - Forecast and Market Analysis to 2023

Summary

GlobalData has released its new PharmaPoint Drug Evaluation report, “Lebrikizumab (Asthma) - Forecast and Market Analysis to 2023”. The asthma market saw very slow growth over the past decade, as it has become saturated with relatively efficacious standard therapies, such as short-acting beta-agonists (SABAs), inhaled corticosteroids (ICSs), inhaled corticosteroids and long-acting beta-agonists (ICS/LABAs), and leukotriene modifiers, and has also been facing increasing generic competition. However, the launch of seven novel targeted biologic agents and once-daily ICS and ICS/LABA therapies delivered by the next-generation inhalers will strongly drive the market growth over the next 10 years. The biologic agents will not only reshape the market growth, but will also mark the beginning of a new era of a personalized approach to asthma treatment. The realization that asthma is a very heterogeneous disease is highly reflected in the rich assortment of these targeted therapies in the late-stage pipeline.

Roche’s lebrikizumab is under development for the treatment of patients with moderate to severe asthma who respond poorly to medium or high doses of ICSs. Lebrikizumab is a first-in-class immunoglobulin G4 (IgG4) humanized mAb that specifically binds to and inhibits the activity of IL-13. IL-13 is a pleiotropic cytokine of the Th2 cell response that contributes to asthma pathogenesis via increased chemokine secretion and mucus hyperexcretion, increased cholinergic-induced contractions, and smooth muscle proliferation (Khurana Hershey, 2003). Clinical studies have correlated the presence of elevated periostin levels with the increased efficacy of lebrikizumab.

Scope

- Overview of Asthma, including epidemiology, etiology, symptoms, diagnosis, pathology and treatment guidelines as well as an overview on the competitive landscape.
- Detailed information on Lebrikizumab including product description, safety and efficacy profiles as well as a SWOT analysis.
- Sales forecast for Lebrikizumab for the top eight countries from 2013 to 2023.
- Sales information covered for the US, France, Germany, Italy, Spain, the UK, Japan and Australia.

Reasons to buy

- Understand and capitalize by identifying products that are most likely to ensure a robust return
- Stay ahead of the competition by understanding the changing competitive landscape for Asthma
- Effectively plan your M&A and partnership strategies by identifying drugs with the most promising sales potential
- Make more informed business decisions from insightful and in-depth analysis of Lebrikizumab performance
- Obtain sales forecast for Lebrikizumab from 2013-2023 in top eight countries (the US, France, Germany, Italy, Spain, the UK, Japan and Australia)

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