1. Market Research
  2. > Healthcare
  3. > Pathology
  4. > Mental Health Market Trends
  5. > Major Depressive Disorder Therapeutics in Major Developed Markets to 2020 - New Launches and Modest Uptake of New Adjunctive Treatments to Offset Patent Expiries

Major Depressive Disorder Therapeutics in Major Developed Markets to 2020 - New Launches and Modest Uptake of New Adjunctive Treatments to Offset Patent Expiries

Summary

GBI Research, the leading business intelligence provider, has released its latest research, "Major Depressive Disorder Therapeutics in Major Developed Markets to 2020 - New Launches and Modest Uptake of New Adjunctive Treatments to Offset Patent Expiries", which provides insights into Major Depressive Disorder (MDD) in the major developed markets of the US, the UK, France, Germany, Italy, Spain, Japan and Canada. The report provides an estimation of market size for 2013, along with market forecast until 2020. It also covers disease epidemiology, treatment algorithms, treatment use patterns, in-depth analysis of the pipeline, clinical trial failure rate and deal analysis for MDD. The report is built using data and information sourced from proprietary databases, primary and secondary research and in-house analysis carried out by GBI Research’s team of industry experts. In 2013, the value of the MDD therapeutics market in major developed countries amounted to an estimated $8.7 billion. The market is forecast to decline at a negative Compound Annual Growth Rate (CAGR) of 1.1% between 2013 and 2020 to reach $8.1 billion. The decline is due to key patent expiries of blockbuster drugs such as Lexapro, Cymbalta, Abilify, and Seroquel XR during the forecast period. The expected launch of few promising pipeline molecules such as brexpiprazole, cariprazine, ALKS-5461, GLYX-13 is likely to offset the key patent expiries. Recently launched Brintellix which has a novel multimodal mechanism of action and is the only drug which can provide improvements in cognitive function is expected to lead the market by the end of forecasting period.

Scope

The report analyzes treatment use patterns, market characterization, pipeline analysis and key licensing and co-development deals MDD in the major developed markets of the US, the UK, France, Germany, Italy, Spain, Japan and Canada.The report includes -
- A brief introduction to MDD, including the disease’s pathophysiology, etiology, diagnosis and treatment algorithms.
- In-depth analysis of currently marketed drugs for MDD, including analysis of their safety, efficacy, treatment patterns and strengths/weaknesses. Including a heat map comparing the drugs in terms of safety and efficacy
- A comprehensive review of the pipeline for MDD, including individual analysis of a number of late-stage pipeline drugs that are likely to enter the market during the forecast period. The pipeline is analyzed on the basis of phase distribution, molecule types, program types, mechanisms of action and molecular targets
- Additional in-depth analysis of pipeline drug clinical trials by phase, trial size, trial duration and program failure rate for each molecule type.
- Multi-scenario forecast data of the market to 2020, taking into account how the market may be affected by the introduction of new drugs, the expiry of key patents on current drugs and the changes in disease epidemiology across the key developed markets.
Discussion of the drivers and barriers for market growth.
- In-depth analysis of all licensing and co-development deals that have occurred in the MDD market since 2006.

Reasons to buy

The report will enhance your decision-making capability by allowing you to -
- Understand the MDD pipeline and the factors that indicate that it is becoming more innovative. Observe detailed profiles for promising pipeline products and gain insights into how they are likely to compete in the market and who their main competitors will be.
- Follow the trends in MDD clinical trial size and duration in relation to industry averages. In addition, the report will enable you to assess the potential risk of future developmental programs for MDD therapeutics, depending on the mechanism of action, by considering the recorded clinical trial failure rates.
- Observe the potential growth patterns expected for the MDD market over the forecast period. Identify which countries are expected to contribute the most to this growth and devise a more effectively tailored country strategy through the understanding of key drivers and barriers in the MDD market
- Accelerate and strengthen your market position by identifying key companies for strategic partnerships.

Table Of Contents

Major Depressive Disorder Therapeutics in Major Developed Markets to 2020 - New Launches and Modest Uptake of New Adjunctive Treatments to Offset Patent Expiries
1 Table of Contents
1 Table of Contents 5
1.1 List of Tables 7
1.2 List of Figures 8
2 Introduction 9
2.1 Etiology 9
2.2 Pathophysiology 10
2.3 Diagnosis 11
2.4 Classification 12
2.5 Epidemiology 13
2.6 Prognosis 14
2.7 Treatment and Management 14
2.7.1 Antidepressants 16
3 Marketed Products 17
3.1 Therapeutic Landscape 17
3.1.1 Lexapro/Cipralex (escitalopram) - Lundbeck/Forest Laboratories 17
3.1.2 Viibryd (vilazodone) - Forest (Actavis) 19
3.1.3 Cymbalta (duloxetine) - Eli Lilly 20
3.1.4 Pristiq (desvenlafaxine) - Pfizer 22
3.1.5 Seroquel XR (quetiapine) - AstraZeneca 24
3.1.6 Brintellix (vortioxetine) - Takeda and Lundbeck 25
3.1.7 Abilify (aripiprazole) - Otsuka 26
3.2 Comparative Efficacy and Safety 27
4 Major Depressive Disorder Market to 2020 - Pipeline Products 29
4.1 Overall Pipeline 29
4.2 Pipeline Analysis by Molecule Type 30
4.3 Pipeline Analysis by Mechanism of Action 31
4.4 Clinical Trials 33
4.4.1 Failure Rate 33
4.4.2 Patient Enrollment and Clinical Trial Size 35
4.4.3 Duration 36
4.5 Promising Drug Candidates in the Pipeline 37
4.5.1 OPC-34712 (brexpiprazole) - Otsuka and Lundbeck 37
4.5.2 ALKS-5461 - Alkermes 38
4.5.3 Amitifadine (EB-1010) - Euthymics Bioscience 39
5 Market Forecast to 2020 40
5.1 Geographical Markets 40
5.1.1 Global Market 40
5.1.2 North America 41
5.1.3 Top Five European Countries 44
5.1.4 Japan 47
5.2 Drivers and Barriers 49
5.2.1 Drivers 49
5.2.2 Barriers 50
6 Deals and Strategic Consolidations 51
6.1 Major Licensing Deals 52
6.1.1 Ranbaxy Pharma Enters into Licensing Agreement with Alembic Pharma for desvenlafaxine Base Extended-Release Tablets 53
6.1.2 Forest Labs Enters into Licensing Agreement with Moksha8 for Viibryd 53
6.1.3 AstraZeneca Enters into Collaboration and Licensing Agreement with Targacept 53
6.1.4 Impax Labs Enters into Licensing Agreement with Wyeth 54
6.2 Major Co-development Deals 54
6.2.1 Lundbeck Enters into Co-Development Agreement with Otsuka Pharma 55
6.2.2 Azaya Lundbeck Enters into Co-Development Agreement with Takeda 55
7 Appendix 56
7.1 All Pipeline Drugs by Phase 56
7.1.1 Discovery 56
7.1.2 Preclinical 56
7.1.3 Phase I 57
7.1.4 Phase II 57
7.1.5 Phase III 58
7.1.6 Pre-registration 58
7.1.7 Undisclosed 58
7.2 Market Forecasts to 2019 59
7.2.1 Global 59
7.2.2 US 59
7.2.3 UK 59
7.2.4 France 60
7.2.5 Germany 60
7.2.6 Italy 60
7.2.7 Spain 60
7.2.8 Japan 61
7.2.9 Canada 61
7.3 Market Definitions 61
7.4 Abbreviations 62
7.5 References 63
7.6 Research Methodology 66
7.6.1 Coverage 66
7.6.2 Secondary Research 67
7.6.3 Primary Research 67
7.6.4 Therapeutic Landscape 67
7.6.5 Geographical Landscape 69
7.6.6 Pipeline Analysis 70
7.7 Expert Panel Validation 70
7.8 Contact Us 70
7.9 Disclaimer 70

1.1 List of Tables

Table 1: Major Depressive Disorder Market, Global, Symptoms and Associated Features, 2008 9
Table 2: Major Depressive Disorder Market, Global, Classification and Criteria of Major Depressive Disorder (DSM-IV) and Major Depressive Episode (ICD-10), 2013 12
Table 3: Major Depressive Disorder Market, Global, Prevalence (%), 2011 13
Table 4: Major Depressive Disorder Market, Global, Pharmaceutical Pipeline (Discovery), 2013 56
Table 5: Major Depressive Disorder Market, Global, Pharmaceutical Pipeline (Preclinical), 2013 56
Table 6: Major Depressive Disorder Market, Global, Pharmaceutical Pipeline (Phase I), 2013 57
Table 7: Major Depressive Disorder Market, Global, Pharmaceutical Pipeline (Phase II), 2013 57
Table 8: Major Depressive Disorder Market, Global, Pharmaceutical Pipeline (Phase III), 2013 58
Table 9: Major Depressive Disorder Market, Global, Pharmaceutical Pipeline (Pre-registration), 2013 58
Table 10: Major Depressive Disorder Market, Global, Pharmaceutical Pipeline (Undisclosed), 2013 58
Table 11: Major Depressive Disorder Market, Global, Forecast Data, 2013-2020 59
Table 12: Major Depressive Disorder Market, US, Forecast Data, 2013-2020 59
Table 13: Major Depressive Disorder Market, UK, Forecast Data, 2013-2020 59
Table 14: Major Depressive Disorder Market, France, Forecast Data, 2013-2020 60
Table 15: Major Depressive Disorder Market, Germany, Forecast Data, 2013-2020 60
Table 16: Major Depressive Disorder Market, Italy, Forecast Data, 2013-2020 60
Table 17: Major Depressive Disorder Market, Spain, Forecast Data, 2013-2020 60
Table 18: Major Depressive Disorder Market, Japan, Forecast Data, 2013-2020 61
Table 19: Major Depressive Disorder Market, Canada, Forecast Data, 2013-2020 61

1.2 List of Figures

Figure 1: Major Depressive Disorder Market, Global, Pathology, 2010 10
Figure 2: Major Depressive Disorder Market, Global, Stages of Major Depressive Disorder and Respective Treatment Approach, 2010 15
Figure 3: Major Depressive Disorder Market, Global, Treatment Phases, 2010 16
Figure 4: Major Depressive Disorder Market, Global, Lexapro (escitalopram) Annual Sales ($bn), 2006-2013 19
Figure 5: Major Depressive Disorder Market, Global, Viibryd (vilazodone) Annual Sales ($m), 2011-2013 20
Figure 6: Major Depressive Disorder Market, Global, Cymbalta (duloxetine) Annual Sales ($bn), 2005-2013 22
Figure 7: Major Depressive Disorder Market, Global, Pristiq (desvenlafaxine) Annual Sales ($m), 2009-2013 23
Figure 8: Major Depressive Disorder Market, Global, Seroquel XR (quetiapine) Annual Sales ($bn), 2008-2013 25
Figure 9: Major Depressive Disorder Market, Global, Abilify (aripiprazole) Annual Sales ($bn), 2005-2013 27
Figure 10: Major Depressive Disorder Market, Global, Comparative Safety and Efficacy of Marketed Products Heatmap, 2013 28
Figure 11: Major Depressive Disorder Market, Global, Pipeline by Stage of Development, Program Type and Route of Administration, 2013 30
Figure 12: Major Depressive Disorder Market, Global, Pipeline by Molecule Type and Stage of Development, 2013 31
Figure 13: Major Depressive Disorder Market, Global, Pipeline by Mechanism of Action, 2013 32
Figure 14: Major Depressive Disorder Market, Global, Pipeline by Mechanism of Action, Molecule Type and Stage of Development, 2013 33
Figure 15: Major Depressive Disorder Market, Global, Clinical Trial Failure Rate (%), 2013 34
Figure 16: Major Depressive Disorder Market, Global, Clinical Trial Failure Rate by Mechanism of Action (%), 2013 35
Figure 17: Major Depressive Disorder Market, Global, Clinical Trial Size (Participants), 2013 36
Figure 18: Major Depressive Disorder Market, Global, Pipeline Clinical Trial Duration (months), 2013 37
Figure 19: Major Depressive Disorder Market, Global, Treatment Use Patterns and Market Size, 2013-2020 41
Figure 20: Major Depressive Disorder Market, US and Canada, Treatment Use Patterns (million), 2013-2020 42
Figure 21: Major Depressive Disorder Market, US and Canada, Annual Cost of Therapy ($), 2013-2020 43
Figure 22: Major Depressive Disorder Market, US and Canada, Market Size, 2013-2020 44
Figure 23: Major Depressive Disorder Market, Top Five European Markets, Treatment Use Patterns (million), 2013-2020 45
Figure 24: Major Depressive Disorder Market, Top Five European Markets, Annual Cost of Therapy ($), 2013-2020 46
Figure 25: Major Depressive Disorder Market, Top Five European Markets, Market Size ($m), 2013-2020 47
Figure 26: Major Depressive Disorder Market, Japan, Treatment Use Patterns (million), 2013-2020 48
Figure 27: Major Depressive Disorder Market, Japan, Annual Cost of Therapy ($), 2013-2020 48
Figure 28: Major Depressive Disorder Market, Japan, Market Size ($m), 2013-2020 49
Figure 29: Major Depressive Disorder Market, Global, Deals by Value, Year and Stage of Development, 2006-2013 51
Figure 30: Major Depressive Disorder Market, Global, Deals by Phase, Molecule Type and Mechanism of Action, 2006-2013 52
Figure 31: Major Depressive Disorder Market, Global, Licensing Deals by Geography, 2006-2013 53
Figure 32: Major Depressive Disorder Market, Global, Co-development Deals by Geography, 2006-2013 54
Figure 33: GBI Research Market Forecasting Model (Example) 69

View This Report »

Get Industry Insights. Simply.

  • Latest reports & slideshows with insights from top research analysts
  • 24 Million searchable statistics with tables, figures & datasets
  • More than 10,000 trusted sources
24/7 Customer Support

Talk to Veronica

+1 718 514 2762

Purchase Reports From Reputable Market Research Publishers
PharmaPoint: Major Depressive Disorder - Global Drug Forecast and Market Assessment to 2025

PharmaPoint: Major Depressive Disorder - Global Drug Forecast and Market Assessment to 2025

  • $ 10995
  • Industry report
  • October 2016
  • by Global Data

PharmaPoint: Major Depressive Disorder - Global Drug Forecast and Market Assessment to 2025 Summary Major depressive disorder (MDD) is one of the most common psychiatric diseases worldwide. It is characterized ...

Anxiety Disorders And Depression Treatment Market Analysis By Product (Antidepressant Drugs, SSRIs, SNRIs, Benzodiazepines, Devices And Therapy, TNS, DBS, VBS), By Indication (MDD, OCD, Phobia), And Segment Forecasts, 2014 - 2025

Anxiety Disorders And Depression Treatment Market Analysis By Product (Antidepressant Drugs, SSRIs, SNRIs, Benzodiazepines, Devices And Therapy, TNS, DBS, VBS), By Indication (MDD, OCD, Phobia), And Segment Forecasts, 2014 - 2025

  • $ 4950
  • Industry report
  • December 2016
  • by Grand View Research

The global anxiety disorders and depression treatment market is expected to reach a value of USD 18.3 billion by 2025. The rising incidence of depression worldwide is anticipated to drive the market growth ...

EpiCast Report: Major Depressive Disorder - Epidemiology Forecast to 2025

EpiCast Report: Major Depressive Disorder - Epidemiology Forecast to 2025

  • $ 3995
  • Industry report
  • October 2016
  • by Global Data

EpiCast Report: Major Depressive Disorder - Epidemiology Forecast to 2025 Summary Major depressive disorder (MDD), also known as clinical depression or major depression, is widely recognized as a mood ...


ref:plp2014

Reportlinker.com © Copyright 2017. All rights reserved.

ReportLinker simplifies how Analysts and Decision Makers get industry data for their business.