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3D Cell Cultures: Technologies and Global Markets

  • January 2015
  • -
  • BCC Research
  • -
  • 222 pages

REPORT HIGHLIGHTS

The three dimensional cell culture market was $438 million in 2013. This market is expected to grow to $586.1 million and about $2.2 billion in 2019, a compound annual growth rate(CAGR) of 30.1%.

This report provides:

An overview of the global markets and technologies for 3D cell cultures.
Analyses of global market trends, with data from 2013, estimates for 2014, and projections of compound annual growth rates (CAGRs) through 2019.
Information on 3D technologies with a focus on representative platforms including cube, spherical droplet, stacked plate, magnetic bead, and other platforms.
Value chain analysis at the following levels: key innovation or founding intellectual property, prototyping, beta testing, and research collaborations or reltationship building.
Analysis of the market's dynamics, specifically growth drivers, restraints, and opportunities.
Relevant patent analysis including recent activity and a list of key patents.
Comprehensive profiles of major players in the industry.

SCOPE OF REPORT

The scope of the report encompasses the major types of 3D cell culture that have been used, as well as the major applications being developed by industry, academic researchers and their commercialization offices, and government agencies. It analyzes current market status, examines future market drivers and presents forecasts of growth over the next five years. Technology developments, including the latest trends, are discussed. Other influential factors such as screening strategies for pharmaceuticals have also been included.

Table Of Contents

3D Cell Cultures: Technologies and Global Markets

Chapter- 1: INTRODUCTION - Complimentary 3

STUDY GOALS AND OBJECTIVES
REASONS FOR DOING THE STUDY
SCOPE OF REPORT
INTENDED AUDIENCE
METHODOLOGY AND INFORMATION SOURCES
ANALYST'S CREDENTIALS
RELATED BCC RESEARCH REPORTS
BCC RESEARCH WEBSITE
DISCLAIMER

Chapter- 2: SUMMARY 4

Table Summary : THREE-DIMENSIONAL CELL CULTURE MARKET, THROUGH 2019
Figure Summary : THREE-DIMENSIONAL CELL CULTURE MARKET, 2013-2019

Chapter- 3: TISSUE AND CELL CULTURE 15

OVERVIEW
TISSUE
CELLS
TISSUE CULTURE AND CELL CULTURE DEFINITIONS
OBTAINING CELL CULTURES
CELL TYPES BASED ON MORPHOLOGY
CELL TYPES BASED ON HYBRIDOMAS
CELL CULTURE: BASIC REQUIREMENTS
BASIC CELL CULTURE SYSTEMS
HISTORY AND EARLY APPLICATIONS

Chapter- 4: TISSUE AND CELL CULTURE SYSTEMS LANDSCAPE 10

LARGE-SCALE MANUFACTURE OF BIOPHARMACEUTICALS AND VACCINES
SMALL-SCALE ADHERENT TO MAKE SOMATIC CELLS, STEM CELLS AND TISSUES
TECHNOLOGY OVERVIEW BY CELL CULTURE TYPE
ADHERENT APPROACHES
THREE-DIMENSIONAL BIOREACTORS
REVENUE ESTIMATE
Table 3 : CELL CULTURE APPLICATIONS

Chapter- 5: RESEARCH LANDSCAPE AND CONSUMABLES USED IN THREE-DIMENSIONAL CELL CULTURE 15

MICROPLATES
CELLOMICS OVERVIEW
TWO-DIMENSIONAL CULTURES VERSUS THREE- DIMENSIONAL CULTURES
REVENUE SUMMARY
REVENUE ESTIMATE

Chapter- 6: THREE-DIMENSIONAL TECHNOLOGIES AND BASIC PRODUCTS 34

MICROTITER PLATES PROVIDE PLATFORM
THREE-DIMENSIONAL CELL CULTURE TECHNOLOGIES
IMPORTANCE OF TWO-DIMENSIONAL VERSUS THREE- DIMENSIONAL SYSTEMS
BASIC CELL CULTURE VARIABLES
THREE-DIMENSIONAL TECHNOLOGY AND PRODUCTS
REVENUE SUMMARY
REVENUE ESTIMATE

Chapter- 7: ASSAY KITS AND CONTRACT RESEARCH ORGANIZATION SERVICES 13

BASIC CELL CULTURE VARIABLES
REVENUE SUMMARY
LEADING SUPPLIERS

Chapter- 8: THREE-DIMENSIONAL MODELS FOR CANCER 20

CANCER AT CELLULAR LEVEL OVERVIEW
APPROACHES TO DATE
THREE-DIMENSIONAL REQUIREMENTS
THREE-DIMENSIONAL BENEFITS TO CANCER RESEARCH
BREAST CANCER AS A DRIVER OF THREE-DIMENSIONAL CULTURES
MELANOMA AS A DRIVER OF THREE-DIMENSIONAL CULTURES
THREE-DIMENSIONAL SYSTEMS IN CANCER RESEARCH
THREE-DIMENSIONAL ENGINEERED SCAFFOLDS
LEARNINGS FROM DRUG SENSITIVITY AND RESISTANCE
CELLULAR SIGNALING
DRUG SCREENING
FUTURE HORIZONS
STANDARDS CHALLENGE
WE'VE COME A LONG WAY

Chapter- 9: LANDSCAPE FOR TOXICOLOGY AND DRUG SAFETY TESTING 35

TOXICOLOGY BACKGROUND
CHRONIC AND REPEATED DOSE TOXICITY
CARCINOGENICITY AND GENOTOXICITY
REPRODUCTIVE AND DEVELOPMENTAL TOXICITY
ENDOCRINE DISRUPTOR SCREENING
TOXICOKINETICS AND ADME
IN VITRO DEVELOPMENTS
ORGANOTYPIC MODELS
ABSORPTION BARRIER MODELS
OTHER APPLICATIONS IN LIVER TOXICITY
KIDNEY TOXICITY APPLICATIONS
FUTURE CHALLENGE: STEM-CELL DERIVED KIDNEY CELLS
PANCREATIC TOXICOLOGY APPLICATIONS
CARDIOVASCULAR SAFETY TESTING OF NEW DRUG CANDIDATES
REVENUE ESTIMATE

Chapter- 10: THREE-DIMENSIONAL CULTURES AND THE LIVER 24

UNIQUENESS AND COMPLEXITY OF LIVER
LIVER AS A KEY DRIVER FOR THREE-DIMENSIONAL INNOVATION
IN VITRO LIVER APPLICATIONS
IN VIVO LIVER FUNCTION AND STRUCTURE
LIVER METABOLISM
LIVER IN VITRO MODELS
CO-CULTURES OF HEPATOCYTES AND MACROPHAGES
THREE-DIMENSIONAL LIVER MODELS
DETECTED HEPATOSPHERE STRUCTURES AND FUNCTIONALITY
IDEAL CRITERIA
DRUG RESISTANCE
TRANSPORTER STUDIES
ACHIEVING HETEROTYPIC CELL-CELL CONTACTS
SUMMARY LEARNINGS
UNMET NEEDS AND FUTURE DRIVERS OF INNOVATION
MORPHOGEN SIGNALING
MICROFLUIDICS APPLICATIONS

Chapter- 11: THREE-DIMENSIONAL CULTURE ROLE IN STEM CELLS 8

EARLY LEARNINGS
EMBRYOGENESIS
THREE-DIMENSIONAL STEM CELL CULTURE SYSTEMS
CONTROLLING EMBRYOID BODY FORMATION
APPLICATIONS
REVENUE ESTIMATE

Chapter- 12: THREE-DIMENSIONAL NEXT-GENERATION OUTLOOK 8

OVERVIEW
CANCER
LIVER
REGENERATIVE MEDICINE AND CELL THERAPY
BIOLOGICS DEVELOPMENT
CHARACTERIZATION OF NEW CELL LINES
FUTURE CHALLENGES

Chapter- 13: COMPANY PROFILES 28

3D BIOMATRIX INC.
3D BIOTEK LLC
3D CELL TECHNOLOGIES LLC
ACEA BIOSCIENCES INC.
AKRON BIOTECHNOLOGY LLC
AMSBIO LLC
APPLIKON BIOTECHNOLOGY
BIOGELX LTD.
CELLULAR DYNAMICS INTERNATIONAL INC.
CORNING LIFE SCIENCES
CYTOO INC.
GE HEALTHCARE LIFE SCIENCES
GREINER BIO-ONE BVBA
HEPREGEN CORP.
HµREL CORP.
INSPHERO AG
KIYATEC INC.
MEDICYTE GMBH
METABOLON INC.
MOLECULAR DEVICES LLC
NANO3D BIOSCIENCES INC.
ORGANOVO HOLDINGS INC.
REINNERVATE LTD
STRATATECH CORP.
SYNVIVO INC.
TAP BIOSYSTEMS
THERMO FISHER SCIENTIFIC
VISTAGEN THERAPEUTICS INC.
WYSS INSTITUTE FOR BIOLOGICALLY INSPIRED ENGINEERING AT HARVARD UNIVERSITY
ZEN-BIO INC.

Chapter- 14: INTELLECTUAL PROPERTY ANALYSIS 5

Table 28 : PATENTS AND APPLICATIONS, 2006-2012

List of Tables

Summary Table : THREE-DIMENSIONAL CELL CULTURE MARKET, THROUGH 2019
Table 1 : TISSUE TYPES
Table 2 : CELL TYPES
Table 3 : CELL CULTURE APPLICATIONS
Table 4 : LEADING BIOREACTOR SUPPLIERS, 2014
Table 5 : THREE-DIMENSIONAL BIOREACTOR AND MICROCARRIERS MARKET, THROUGH 2019
Table 6 : HIGH-CONTENT SCREENING SUPPLIERS AND KEY ATTRIBUTES, JANUARY 2014
Table 7 : LABEL-FREE TECHNOLOGIES AND SUPPLIERS, JANUARY 2014
Table 8 : AUTOMATED PATCH CLAMPING COMPANIES AND TECHNOLOGIES, JANUARY 2014
Table 9 : LEADING TISSUE PRODUCT SUPPLIERS, JANUARY 2014
Table 10 : LEADING CELL LINE SUPPLIERS, JANUARY 2014
Table 11 : LEADING PRIMARY CELL SUPPLIERS, JANUARY 2014
Table 12 : LEADING STEM CELL SUPPLIERS, JANUARY 2014
Table 13 : CELLS AND REAGENTS USED IN THREE-DIMENSIONAL CELL CULTURE MARKET, THROUGH 2019
Table 14 : CELLS USED IN THREE-DIMENSIONAL CELL CULTURE MARKET BY TYPE, THROUGH 2019
Table 15 : REAGENTS, MEDIA AND SERA USED IN THREE-DIMENSIONAL CELL CULTURE MARKET, 2013-2019
Table 16 : LEADING REAGENT, MEDIA AND MICROPLATE SUPPLIERS, JANUARY 2014
Table 17 : THREE-DIMENSIONAL TECHNOLOGY PRODUCT MARKET, THROUGH 2019
Table 18 : THREE-DIMENSIONAL STANDALONE TECHNOLOGY PRODUCT MARKET, THROUGH 2019
Table 19 : TYPICAL ASSAY ENDPOINTS AND TESTS
Table 20 : LEADING PRECLINICAL CONTRACT RESEARCH ORGANIZATIONS, JANUARY 2014
Table 21 : ASSAYS KIT AND CONTRACT RESEARCH ORGANIZATIONS SERVICE MARKET, 2013-2019
Table 22 : COMMON THREE-DIMENSIONAL ASSAYS
Table 23 : THREE-DIMENSIONAL TUMOR MODELS DEVELOPED FOR DRUG DISCOVERY, JUNE 2014
Table 24 : THREE-DIMENSIONAL CULTURE USED IN CANCER APPLICATIONS MARKET, THROUGH 2019
Table 25 : IN VITRO AND IN VIVO ASSAYS IN THE TIER 1 SCREENING BATTERY, JANUARY 2014
Table 26 : THREE-DIMENSIONAL CULTURES USED IN PREDICTIVE TOX APPLICATIONS MARKET, THROUGH 2019
Table 27 : THREE-DIMENSIONAL CULTURES USED IN STEM CELL RESEARCH APPLICATIONS MARKET, THROUGH 2019
Table 28 : PATENTS AND APPLICATIONS, 2006-2012

List of Figures

Summary Figure : THREE-DIMENSIONAL CELL CULTURE MARKET, 2013-2019
Figure 1 : TECHNOLOGY MATURITY

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