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Complete 2015-16 Global Cord Blood Banking Industry Report

  • August 2015
  • -
  • BioInformant Worldwide, L.L.C.
  • -
  • 204 pages

This 204 page global strategic report is a must-read document for cord blood banking executives and investors In addition to containing market size, segments, trends, and projections through 2020, it contains a 40-question, 52-page survey of 600+ recent and expectant parents worldwide Additionally, BioInformant has been tracking the cord blood banking industry for a decade (2006 to present) using dashboards of key industry metrics, combined with a system of alerts that identify unexpected variation

The global cord blood banking industry has matured substantially over the past few years, creating both serious threats and novel opportunities

Serious threats to the industry include:

New accreditation requirements that have increased the cost structure of cord blood banks
A decline in cord blood transplants, within the US and other geographical regions
Low rates of turnover for stored cord blood units
Expensive cord blood transplantation procedures, costing from $200-300K each
Difficulty with educating obstetricians about cellular therapies
Poor press coverage in many regions worldwide, including major news outlets
Other uncontrollable factors that could threaten the industry include: new legislation, changes in transplant reimbursement, continually evolving accreditation requirements, the potential for competitive approaches to be shown as more optimal, patent challenges for processing or transplant technologies, changes in public perception of private vs public banking, shift in policy recommendations by influential medical organizations, and changes in government support

Marketing pressures are also impacting the industry, with the term “cord blood” becoming one of the 20 most expensive search terms on Google, reaching more than $20 per click for global search traffic and close to $40 per click for US search traffic

However, there are also emerging opportunities, including:

The potential to expand market size through increasing public awareness
New clinical trial data supporting applications for hematopoietic stem cells (HSCs) from cord blood and mesenchymal stem cells (MSCs) from cord tissue
Improving public perception toward stem cell therapies
Substantial deal-making within the industry, including mergers, acquisitions, and funding rounds
The potential for cross-organizational collaboration through formation of Cord Blood Industry Associations (occurring in within US and South America)
A trend toward diversification within the industry, with cord blood banks effectively becoming stem cell banks through the storage of cord blood, cord tissue, and in some cases, placental tissue, amniotic fluid, and more
Within this rapidly evolving ecosystem, those who choose to commit to understanding current opportunities and threats will be positioned for a substantial strategic advantage

A Global Market Requires Global Understanding

While these factors vary somewhat by market, there is a substantial advantage to having a global understanding of the market You need to understand successes and failures by region to be fully informed of your competitive environment You need to have a firm understanding of emerging trends that could expand to new regions and impact your business model In addition, research advances, clinical trial findings, and technology advances do not know international boundaries They are shared nearly instantly from region-to-region

The cord blood market is global in nature and understanding dynamics limited to your region is not sufficient for making strategic, informed, and profitable decisions

Furthermore, cord blood banks now exist in every developed country, as well as within most developing nations With approximately 500 cord blood banks operating worldwide, maturation of the global cord blood market means that each cord blood bank is now fighting harder for market share

Key Report Findings

The report is designed to guide the decision-making of cord blood banks worldwide, as well as to advise private, corporate, and institutional investors entering into this market

As such, it considers a range of metrics that impact the global cord blood banking market It includes trend rate data for cord blood clinical trials, patents, grants, scientific publications and more For instance, there are now more than 500 studies involving cord blood listed on wwwClinicalTrialsgov, and there have been hundreds of patents related to cord blood collection, processing, and storage filed through the United States Patent and Trademark Office (wwwUSPTOgov) Globally, this patent count is even larger

Additionally, the year-over-year increase in scientific publications on PubMedgov containing the term “cord blood” has been increasing PubMedgov is a global database of scientific publications containing more than 24 million citations for biomedical literature, which makes it an excellent resource for gauging biomedical research trends However, grant rate data reveals that funding for cord blood related research has been declining from 2012 to present

BioInformant also analyzes the types of investments being made within the cord blood marketplace, including investments made by:

ABS Capital Partners & HLM Management
KKR & Company
Bay City Capital
GTCR, LLC
Excalibur

Key report findings include:

Market size determinations for the global cord blood market
Trend rate data for umbilical cord blood grants, patents, and scientific publications
Clinical trial rate analysis, including comparison of cord blood vs cord tissue frequency
Rates of global cord blood storage (units per year)
Rates of global cord blood transplant (units per year)
Current and future conditions treatable with cord blood
Probability of requiring a stem cell transplant by age
Trends in medical opinions of cord blood banking
Changes in legislative support for cord blood banking
Investors impacting the global cord blood banking marketplace
Competitive environment analysis, including assessment of cord blood market leaders
Influential alliances within the cord blood industry
“SWOT” analysis for global cord blood industry (Strengths, Weaknesses, Opportunities, Threats)
Crucial trends and unmet market needs

Table Of Contents

Complete 2015-16 Global Cord Blood Banking Industry Report
I Abstractp12
Overview of Technical and Medical Characteristics of Cord Blood p 17
A Introduction to Cord Blood and Cord Tissue
B Definitions and Nomenclature
C Technical Advantages of Cord Blood
- (Image) TECHNICAL ADVANTAGES OF CORD BLOOD TRANSPLANT, OVER BONE MARROW OR
PERIPHERAL BLOOD STEM CELL TRANSPLANT
D Likelihood of Needing a Stem Cell Transplant
1 Childhood Probability
- (Table) CHILDHOOD PROBABILITY OF REQUIRING A STEM CELL TRANSPLANT
2 Adulthood Probability
- (Table) ADULTHOOD PROBABILITY OF REQUIRING A STEM CELL TRANSPLANT
- (Chart) LIKELIHOOD OF REQUIRING A STEM CELL TRANSPLANT (FROM CORD BLOOD,
BONE MARROW, OR PERIPHERAL BLOOD)
E Comparison of Cord Blood, Bone Marrow, and Peripheral Blood Stem Cell Transplant
- (Image) GROUNDBREAKING YEARS IN TRANSPLANT HISTORY
F Conditions Treatable with Cord Blood Transplant
- (Image) CORD BLOOD TREATMENT OPTIONS: NOW and IN THE FUTURE
- (Table) DISEASE CATEGORIES TREATABLE WITH HEMATOPOIETIC STEM CELL TRANSPLANT
- (Table) FUTURE DISEASE CATEGORIES TREATABLE WITH CORD BLOOD TRANSPLANT
III Cord Blood Market Overviewp27
A Market Variation
B Cord Blood Banking Structures
- (Table) FREE CORD BLOOD PROGRAM FOR FAMILIES IN NEED IN THE UNITED STATES
C Accreditation Standards and Requirements
1 Types of Accreditation
2 AABB Accreditation
- (Table) COUNTRIES CONTAINING AABB ACCREDITED CORD BLOOD BANKS
- (Chart) COUNTRIES WITH AABB ACCREDITED CORD BLOOD FACILITIES
IV Cord Tissue Market Overviewp34
A History of Cord Tissue Storage
B Comparison of Cord Blood and Cord Tissue Storage
- (Image) COMPARISON OF UMBILICAL CORD BLOOD VS UMBILICAL CORD TISSUE
C Clinical Trials Investigating Cord Tissue Derived Mesenchymal Stem Cells (CT-MSCs)
- (Table) MEDICAL CONDITIONS BEING INVESTIGATED FOR POTENTIAL TO BE TREATED WITH CORD
TISSUE DERIVED MESENCHYMAL STEM CELL (CT-MSCs)
- (Image) SOURCES OF MESENCHYMAL STEM CELLS
D Market Penetration of Cord Tissue within the US
- (Table) US CORD BLOOD BANKS OFFERING CORD TISSUE STORAGE IN 2013
- (Table) US CORD BLOOD BANKS OFFERING CORD TISSUE STORAGE IN 2015
E Pricing of Cord Tissue Storage (Global Analysis)
- (Table) PRICING STRUCTURES FOR CORD TISSUE STORAGE
V Timeline of Key Cord Blood Industry Eventsp41
VI Key Processing Technologies within Cord Blood Marketplacep45

- (Image) THE FOUR KEY PROCESSING TECHNOLOGIES OPERATING WITHIN THE CORD BLOOD
BANKING MARKET
A AutoXpress® Platform (“AXP®”) and BioArchive System
(By Thermogenesis, a Division of Cesca Therapeutics in Rancho Cordova, California, USA)
B Sepax (By Biosafe, in Eysins, Switzerland)
C PrepaCyte®
-CB (By BioE in St Paul, Minnesota, USA)
D Cord Blood 20TM (By Americord, in New York, NY, USA)
VII Strategic Collaborations: Key Alliances within Cord Blood Industryp48
A Cord Blood Registry and Women's Health Alliance (Largest Women's Healthcare Groups)
B ViaCord and Destination Maternity (Largest Retailer of Maternity Clothing)
C Precious Cells Miracle and the Croydon Health Services NHS Trust
D CarePilot and “Cord for Life” (Lifeforce Cryobank's Cord Blood Storage Program)
E Cesca Therapeutics and UpState Public Cord Blood Bank
VIII Cord Blood Industry Trend: Diversification into Stem Cell Bio-Bankingp53
A Overview
- (TABLE) TYPES OF STEM CELL BIO-BANKING
B Dental Stem Cell Storage
- (Table) COMPANIES OFFERING DENTAL STEM CELL STORAGE (BOTH DIVERSIFIED CORD
BLOOD BANKS AND SPECIALTY COMPANIES)
C Adipose-Derived Stem Cell Storage
- (Table) COMPANIES OFFERING ADIPOSE-DERIVED STORAGE (BOTH DIVERSIFIED CORD BLOOD
BANKS AND SPECIALTY COMPANIES)
D Other Types of Stem Cell Bio-Banking: Placental Tissue, Menstrual Stem Cells, Peripheral Blood
Stem Cells, Bone Marrow Stem Cells, and More
IX Comparative Analysis of Cord Blood Market Leadersp57
A Largest Cord Blood Banks, by Units Banked
1 Top 3 US Cord Blood Banks
a Cord Blood Registry (Acquired by AMAG Pharmaceuticals)
b ViaCord
c Cryo-Cell International
d Comparative Analysis of Top 3 US Cord Blood Banks
- (Table) COMPARATIVE ANALYSIS OF SERVICES and FEATURES (US)
- (Table) COMPARATIVE ANALYSIS OF PRICING (US)
2 Top 3 Global Cord Blood Banks
a Cryo-Save
b CordVida
c China Cord Blood Corporation
d Comparative Analysis of Top 3 Global Cord Blood Banks
- (Table) COMPARATIVE ANALYSIS OF SERVICES and FEATURES (Worldwide)
B Fastest Growing Cord Blood Banks, by Revenue
1 US Analysis
2 International Analysis
- (Chart) China Cord Blood Corporation Compounded Annual Growth Rates (CAGR), FY2009-
FY2014
- (Chart) China Cord Blood Corporation's Public Division Compounded Annual Growth Rates
(CAGR), FY2009-FY2014
X “SWOT” Analysis for Cord Blood Marketplacep66
- (Image) SWOT MATRIX
A Strengths
- (Table) STRENGTHS OF THE GLOBAL CORD BLOOD BANKING MARKET
B Weaknesses
- (Table) WEAKNESSES OF THE GLOBAL CORD BLOOD BANKING MARKET
C Opportunities
- (Table) OPPORTUNITIES WITHIN THE GLOBAL CORD BLOOD BANKING MARKET
D Threats
- (Table) THREATS TO THE GLOBAL CORD BLOOD BANKING MARKET
XI Trend Rate Analysisp73
A Scientific Publication Rate Analysis
- (Table) TREND RATE ANALYSIS OF SCIENTIFIC PUBLICATION RATES, BY YEAR
- (Chart) ANALYSIS OF SCIENTIFIC PUBLICATIONS CONTAINING “CORD BLOOD” (SOURCE:
PUBMED)
- (Chart) FIVE-YEAR FUTURE PROJECTION ANALYSIS OF SCIENTIFIC PUBLICATIONS CONTAINING
“CORD BLOOD” (SOURCE: PUBMED)
- (Chart) ANALYSIS OF SCIENTIFIC PUBLICATIONS CONTAINING “CORD TISSUE” (SOURCE:
PUBMED)
- (Chart) FIVE-YEAR FUTURE PROJECTION ANALYSIS OF SCIENTIFIC PUBLICATIONS CONTAINING
“CORD TISSUE” (SOURCE: PUBMED)
B Grant Funding Analysis
- (Table) TREND RATE ANALYSIS OF CORD BLOOD GRANTS, BY YEAR (RePORTER Tool)
- (Chart) ANALYSIS OF RESEARCH GRANTS CONTAINING “CORD BLOOD” (SOURCE: RePORTER
TOOL BY NATIONAL INSTITUTES OF HEALTH)
- (Image) DENSITY OF RESEARCH GRANTS IN THE US CONTAINING “CORD BLOOD” IN
DESCRIPTION
- (Image) EUROPEAN SITES OF ORGANIZATIONS THAT HAVE FUNDED PROJECTS CONTAINING
“CORD BLOOD” IN DESCRIPTION
- (Image) WORLDWIDE SITES OF ORGANIZATIONS THAT HAVE FUNDED PROJECTS CONTAINING
“CORD BLOOD” IN DESCRIPTION
C Patent Analysis
- (Table) PATENTS CONTAINING THE WORD “CORD BLOOD” IN THE TITLE (USPTOGOV)
- (Table) CATEGORICAL BREAKDOWN OF US PATENTS WITH “CORD BLOOD” IN TITLE
- (Chart) CATEGORICAL BREAKDOWN OF US PATENTS WITH “CORD BLOOD” IN TITLE
D Clinical Trial Rate Analysis
1 Quantitative Analysis (Year-by-Year)
- (Table) CLINICAL TRIALS WITH “CORD BLOOD” IN THE DESCRIPTION (CLINICALTRIALSGOV)
- (Chart) NUMBER OF CLINICAL TRIALS WITH “CORD BLOOD” IN THE DESCRIPTION
2 Geographic Analysis
- (Table) GEOGRAPHICAL BREAKDOWN OF CLINICAL STUDIES WITH “CORD BLOOD” IN
DESCRIPTION (CLINICALTRIALSGOV)
- (Image) GEOGRAPHICAL BREAKDOWN OF CLINICAL STUDIES WITH “CORD BLOOD” IN
DESCRIPTION (CLINICALTRIALSGOV)
E Market Penetration Rate of Cord Blood Storage
XII Cord Blood Marketing Analysis: Search Terms “Cord Blood” and “Cord Tissue”p87
- (Image) GOOGLE ADWORDS PRICE-PER-CLICK FOR TERM “CORD BLOOD” (GEOGRAPHY: USA
ONLY)
- (Image) GOOGLE ADWORDS PRICE-PER-CLICK FOR TERM “CORD BLOOD” (GEOGRAPHY:
WORLDWIDE)
- (Image) SEARCH TERMS CONTAINING THE PHRASE “CORD BLOOD” WITHIN THEM (GEOGRAPHY:
USA ONLY)
- (Image) SEARCH TERMS CONTAINING THE PHRASE “CORD BLOOD” WITHIN THEM (GEOGRAPHY:
WORLDWIDE)
- (Table) GOOGLE ADWORDS PAY-PER-CLICK PRICES FOR CORD BLOOD RELATED SEARCH TERMS
XIII Key Cord Blood Industry Benchmarksp91
A Medical Society Opinions of Cord Blood Banking
- (Table) CORD BLOOD BANKING OPINIONS ISSUED BY MEDICAL SOCIETIES
B Rates of Parental Awareness
- (Image) LACK OF AWARENESS A MAJOR PROBLEM FOR CORD BLOOD PRESERVATION
C Rates of Worldwide Storage, by Year
- (Table) CORD BLOOD BANKING UNITS IN THE BONE MARROW DONORS WORLDWIDE
DATABASE
- (Chart) NUMBER OF CORD BLOOD UNITS IN THE BMDW CORD BLOOD REGISTRY, BY YEAR
- (Chart) TOTAL NUMBER OF CORD BLOOD UNITS IN THE BMDW CORD BLOOD REGISTRY,
JUNE - NOVEMBER 2014
D Transplant Data
- (Image) # OF CORD BLOOD TRANSPLANTS, BY YEAR (BMDW)
E Quality Guarantee Comparison
- (Table) COMPARISON OF LEADING PRIVATE CORD BLOOD BANKS IN THE USA (RANKED BY
VALUE OF "QUALITY GUARANTEE")
XIV Market Size Analysisp100
A Definitions
B Methodology
- (Chart) PERCENT OF GLOBAL CORD BLOOD BANKING MARKET, BY SEGMENT
C Market Size Estimations
- (Table) REVENUE ESTIMATIONS BY MARKET SEGMENT
XV Global Analysis of Cord Blood Market Authoritiesp104
A People: Top Five Cord Blood Influencers
1 Dr Elaine Gluckman; Performed the First Related Cord Blood Transplant
2 Dr Joanne Kurtzberg; Performed First Unrelated Cord Blood Transplant
3 Dr Pablo Rubinstein; Co-founder and Director of the National Cord Blood Program in the New York
Blood Center
4 Dr Hal Broxmeyer; First to Suggest Cord Blood as a Source of Hematopoietic Stem Cells
5 Jeffrey Crouse; CEO of Cord Blood Registry
B Cord Blood Banks: Top Ten Most Influential Cord Blood Banks Worldwide
1 Cord Blood Registry (San Bruno, California, USA)
2 ViaCord (Waltham, Massachusetts, USA)
3 CryoCell (Oldsmar, Florida, USA)
4 China Cord Blood Corporation (Daxing, Beijing, China)
5 Cryo-Save (Zutphen, Netherlands)
6 New York Cord Blood Program (New York City, New York, USA)
7 CordVida: (São Paulo, Brazil)
8 Americord (New York City, New York, USA)
9 Cord Blood America (Las Vegas, Nevada, USA)
10 Crioestaminal (BioCant Park, Portugal)
C Events: Global Cord Blood Conferences and Events
- (Table) GLOBAL CORD BLOOD CONFERENCES and EVENTS
D Investors and Acquisitions Impacting the Cord Blood Market
1 ABS Capital Partners and HLM Management
2 KKR and Company
3 Bay City Capital
4 GTCR, LLC
5 Related Industry Investments
XVI INVESTORS AND ACQUISITIONS IMPACTING THE CORD BLOOD MARKETp109
- (Table) INDUSTRY INVESTORS WITHIN CORD BLOOD MARKET
- (Table) MAJOR ACQUISITIONS WITHIN CORD BLOOD MARKET
A Investors Impacting the Global Cord Blood Market
1 ABS Capital Partners and HLM Management
2 KKR and Company
3 Bay City Capital
4 GTCR, LLC
5 Excalibur (Private Equity Firm) and Christopher Evans (Biotech Entrepreneur)
B Acquisitions Impacting the Global Cord Blood Market
1 Summary of Acquisitions
2 Strange Similarities between Acquisition of Cord Blood Registry and ViaCord
a Sample Multiple on Revenue
b Same Location of Acquiring Company
c Two Largest Cord Blood Banks within the United States
- (Table) COMPARISON OF ACQUISITION OF CORD BLOOD REGISTRY BY AMAG
PHARMACEUTICALS AND VIACORD BY PERKINELMER
XVII Cord Blood Industry Analysis: Geographic Regions with Shifting Conditionsp114
A China
B France and Italy
C Taiwan
D Ecuador
E South Africa
F Brazil
XVIII Cord Blood Banking Survey: 600+ Recent and Expectant Parents (Geography: Worldwide)p118
A Overview of Survey Design
B Population Characteristics of Respondents (Questions 1 - 7; All Respondents)
C Survey Results: Respondents who Banked Privately (Questions 8 - 25; 61 Respondents)
D Survey Results: Respondents who Banked Publicly (Questions 26 - 29; 154 Respondents)
E Survey Results: Respondents who Did Not Bank (Question 30 - 33; 377 Respondents)
F General Findings (Questions 34 - 40; All Respondents)
XIX Summary of Conclusionsp169
APPENDICES
APPENDIX A - Existing Conditions Treatable with Hematopoietic Stem Cell Transplantp171
APPENDIX B - AABB Accredited Cord Blood Banks Worldwidep174
APPENDIX C - List of US Cord Blood Banks, by Type of Bank (Private, Hybrid, or Public)p176
APPENDIX D - Global List of All Active Cord Blood Banks Worldwidep178

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