1. Market Research
  2. > Healthcare
  3. > Pathology
  4. > Cancer Market Trends
  5. > Hematological Malignancies: Multiple Myeloma (MM) – Early and Robust Diagnosis along with New Treatment Options can have Considerable Impact on Management of the Disease

While targeting unmet needs in the treatment of hematological malignancies/ cancer through innovative drug development strategies have witnessed favorable outcomes, the specific choice of the therapies is dependent on the identification of important genomic alterations in cancerous cells that allow for the tumor’s sub classification. Over the past decade, Proteasome inhibitor and the immunomodulatory drugs have become the cornerstone of treatment for pts with Multiple Myeloma (MM) resulting in improved survival. However, eventually all pts relapse and use of modern diagnosis will enable risk stratification to help distinguish pts along the spectrum of the condition.

This can aid in the selection of new treatment options for Relapsed/ Refractory Multiple Myeloma (RRMM) to further improve survival and quality of life of each patient. Two new drugs have successfully fulfilled this need – POMALYST/ IMNOVID (pomalidomide – POM, Celgene, approved) and Kyprolis (carfilzomib-CFZ, Amgen/ Ono Pharma – JP, approved). While novel targets address unmet need, the pertinent Question remains – is there a need for further improvement? What should be the diagnosis criteria and/or novel imaging / diagnostic tools that can further stratify a pts’ risk profile?

Precision medicine approaches in myeloma require fast, robust, and practicable molecular diagnostic tools, and the current diagnostic standard iFISH (interphase fluorescence in situ hybridization) is unable to fulfill any of these criteria. Integration of Diagnostics into therapeutic products/ industry has potential to improve trial design, enhance safety profile, enhance therapeutic efficacy, accelerate trial outcome, and increase commercial success. However, there are few hurdles which are also associated with new model, such as understanding the diagnostic industry, complex trial execution, seeking a ‘right’ diagnostic partner, managing the co-development process, regulatory uncertainty around companion diagnostics and intellectual property issues.

Table Of Contents

Hematological Malignancies: Multiple Myeloma (MM) - Early and Robust Diagnosis along with New Treatment Options can have Considerable Impact on Management of the Disease
1. Executive Summary
2. Disease Overview, Diagnosis, and Current Treatment
2.1 Overview of Diagnostic tools for Multiple Myeloma
2.2 Diagnostic Criteria of Myeloma and Recent Amendment
2.3 Diagnostic Approaches for Multiple Myeloma
2.3.1 Molecular pathogenesis of Myeloma
2.3.2 Unmet Need
2.3.3 New Diagnostics Perspective and Technologies
a ‘Companion' Diagnostics (CDx)
b Genome-wide array
c RAN based technologies
d Next-Generation Sequencing (NGS) technology
3. Diagnostic Tools for Multiple Myeloma
3.1 Affymetrix GeneChip
3.2 SkylineDx MMprofiler
3.3 AgenaBio iPLEX Genotyping
3.4 Signal Genetics MyPRS
3.5 Cancer Genetics Genomic Products
3.6 Illumina NGS
3.7 NeoGenomics CLIA-certified Cancer Test
3.8 Exiqon microRNA PCR
3.9 Regulus Therapeutics microRNA Marker
3.10 Rosetta Genomics Cancer Origin Test
3.11 Sequenta LymphoSIGHT Platform
4. MandA Deals and Market Opportunity in Diagnostic Space
5. Current Therapies
5.1 Newly Diagnosed Multiple Myeloma (NDMM)
5.1.1 Competitive Landscape for NDMM
5.2 Relapsed and/or Refractory Multiple Myeloma (RRMM)
5.2.1 Competitive Landscape for RRMM
5.3 Approved Therapies
5.3.1 Revlimid
5.3.2 Velcade
5.3.1 Kyprolis
5.3.2 POMALYST
5.1 Data Comparison
5.4.1 Newly Diagnosed Multiple Myeloma (NDMM)
5.4.2 Relapsed and/or Refractory Multiple Myeloma (RRMM)
1. Novel Targets
6.1 Monoclonal Antibodies
6.1.1 Elotuzumab
6.1.2 Situximab
6.1.3 Daratumumab
6.1.4 MOR202
6.1.5 SAR650984
6.1.6 BI-505
6.1.7 BHQ880
6.1.8 CT-011
6.1.9 IPH2101/ Lirilumab
6.1.10 BMS-936564 (ulocuplumab)
6.2 Small Molecules
6.2.1 Panobinostat
6.2.2 Ixazomib (MLN9708)
6.2.3 Aplidin (plitidepsin)
6.2.4 ARRY-520 (filanesib)
6.2.5 Oprozomib
6.2.6 KPT-330 (selinexor)
6.2.7 SNS01-T
6.2.8 Ibrutinib
6.2.9 Ricolinostat
6.2.10 Afuresertib
6.2.11 KW-2478
6.2.12 BT-062
2. Clinical Milestones
3. Launch Timeline and Commercial Opportunity of Late-Stage Pipeline
4. MandA/ Licensing Deals and Unpartnered Product Opportunities


View This Report »

Get Industry Insights. Simply.

  • Latest reports & slideshows with insights from top research analysts
  • 24 Million searchable statistics with tables, figures & datasets
  • More than 10,000 trusted sources
24/7 Customer Support

Talk to Veronica

+1 718 514 2762

Purchase Reports From Reputable Market Research Publishers
PharmaPoint: Non-Small Cell Lung Cancer (NSCLC) - Global Drug Forecast and Market Analysis to 2025

PharmaPoint: Non-Small Cell Lung Cancer (NSCLC) - Global Drug Forecast and Market Analysis to 2025

  • $ 10995
  • Industry report
  • November 2016
  • by GlobalData

PharmaPoint: Non-Small Cell Lung Cancer (NSCLC) - Global Drug Forecast and Market Analysis to 2025 Summary Lung cancer is currently is the most common cause of death from cancer worldwide. Of total lung ...

Non-Small Cell Lung Cancer (NSCLC) - 5EU Drug Forecast and Market Analysis to 2025

Non-Small Cell Lung Cancer (NSCLC) - 5EU Drug Forecast and Market Analysis to 2025

  • $ 6995
  • Industry report
  • November 2016
  • by GlobalData

Non-Small Cell Lung Cancer (NSCLC) - 5EU Drug Forecast and Market Analysis to 2025 Summary Lung cancer is currently is the most common cause of death from cancer worldwide. Of total lung cancer incident ...

Immunotherapy Drugs Market by Type of Drugs, Therapy Area, End-User, Region - Global Forecast to 2021

Immunotherapy Drugs Market by Type of Drugs, Therapy Area, End-User, Region - Global Forecast to 2021

  • $ 5650
  • Industry report
  • January 2017
  • by MarketsandMarkets

The global immunotherapy drugs market is projected to reach USD 201.52 billion by 2021 from USD 108.41 billion in 2016, growing at a CAGR of 13.5% during the forecast period of 2016 to 2021. In this report, ...


Download Unlimited Documents from Trusted Public Sources

Hormone and Therapy Market in Pakistan and the US

  • February 2017
    7 pages
  • Hormone  

    Therapy  

    Diabetes  

  • Pakistan  

    United States  

View report >

Breast Cancer Statistics

  • February 2017
    7 pages
  • Breast Cancer  

    Risky Behaviour  

View report >

Cancer and Breast Cancer Statistics in Switzerland

  • February 2017
    138 pages
  • Cancer  

    Breast Cancer  

    Obesity  

  • Switzerland  

View report >

Related Market Segments :

Therapy

ref:plp2015

Reportlinker.com © Copyright 2017. All rights reserved.

ReportLinker simplifies how Analysts and Decision Makers get industry data for their business.