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Lucentis (Macular Edema and Macular Degeneration) - Forecast and Market Analysis to 2023


Macular Edema is a condition where fluid accumulates on the macula, leading to vision impairment or in severe cases even vision loss. The three main types of ME are diabetic macular edema (DME), and macular edema following either a central or branch retinal vein occlusion (ME-CRVO and ME-BRVO). Age-related macular degeneration (AMD) is a painless eye condition which leads to gradual, irreversible, loss of central vision, and is one of the leading causes of blindness among people aged 50 and over in the developed world. Currently the ME and AMD markets are dominated by the use of anti-VEGF monotherapy, however, in recent years, corticosteroid implants have been reaching the ME market which could challenge the stronghold these drugs have in this sector. The AMD market will see the arrival of the first therapies to treat dry AMD, fulfilling a huge unmet need in the management of this retinal disease, and these first-in-class therapies will strongly drive the market growth over the next ten years. The launch of wet AMD adjunctive therapies will also see a significant change in the treatment of AMD patients and have a positive impact on the market growth.

Lucentis (ranibizumab) is an anti-VEGF-A monoclonal antibody (mAb) fragment developed by Genentech/Roche. It is derived from the larger parent molecule, bevacizumab, which is another anti-VEGF drug marketed as Avastin by Genentech/Roche/Chugai. It was hoped that Lucentis, as a lower-molecular-weight, humanized fragment of an immunoglobulin G1 (IgG1) mAb, would result in improved retinal penetration over Avastin, and therefore, confer superior efficacy.


- Overview of Macular Edema and Macular Degeneration, including epidemiology, etiology, symptoms, diagnosis, pathology and treatment guidelines as well as an overview on the competitive landscape.
- Detailed information on Lucentis including product description, safety and efficacy profiles as well as a SWOT analysis.
- Sales forecast for Lucentis for the top seven countries from 2013 to 2023.
- Sales information covered for the US, France, Germany, Italy, Spain, the UK and Japan

Reasons to buy

- Understand and capitalize by identifying products that are most likely to ensure a robust return.
- Stay ahead of the competition by understanding the changing competitive landscape for Macular Edema and Macular Degeneration.
- Effectively plan your M&A and partnership strategies by identifying drugs with the most promising sales potential.
- Make more informed business decisions from insightful and in-depth analysis of Lucentis performance.
- Obtain sales forecast for Lucentis from 2013-2023 in top seven countries (the US, France, Germany, Italy, Spain, the UK and Japan).

Table Of Contents

Lucentis (Macular Edema and Macular Degeneration) - Forecast and Market Analysis to 2023
1 Table of Contents
2 Introduction 9
2.1 Related Reports 10
3 Disease Overview 12
3.1 Macular Degeneration Overview 12
3.1.1 Etiology and Pathophysiology 14
3.1.2 Classification 18
3.1.3 Symptoms and Diagnosis 20
3.2 Macular Edema Overview 23
3.2.1 Etiology and Pathophysiology 24
3.2.2 Classification 27
3.2.3 Symptoms and Diagnosis 28
4 Disease Management 31
4.1 Diagnosis and Treatment Overview 31
4.1.1 Macular Edema Diagnosis 31
4.1.2 Macular Degeneration Diagnosis 31
4.1.3 Treatment Guidelines and Leading Prescribed Drugs 32
4.1.4 Clinical Practice 34
5 Competitive Assessment 48
5.1 Overview 48
6 Lucentis (ranibizumab) 50
6.1 Overview 50
6.2 Efficacy - Macular Degeneration 55
6.3 Efficacy - Macular Edema 55
6.4 Safety 58
6.5 SWOT Analysis 59
6.6 Forecast 59
7 Appendix 61
7.1 Bibliography 61
7.2 Abbreviations 74
7.3 Methodology 78
7.4 Forecasting Methodology 78
7.4.1 Diagnosed ME and AMD Patients 78
7.4.2 Percentage of Drug-Treated Patients 79
7.4.3 General Pricing Assumptions 79
7.4.4 Individual Drug Assumptions 80
7.5 Primary Research - KOLs Interviewed for this Report 81
7.6 Primary Research - High-Prescribers Survey 82
7.7 About the Authors 83
7.7.1 Analyst 83
7.7.2 Therapy Area Director 83
7.7.3 Global Head of Healthcare 84
7.8 About GlobalData 85
7.9 Disclaimer 85

1.1 List of Tables

Table 1: ARM System Classification of AMD 19
Table 2: Symptoms of AMD 20
Table 3: National and International Treatment Guidelines for ME and AMD 33
Table 4: Most Prescribed Drugs for ME and AMD in the Global Markets, 2013 34
Table 5: Leading Treatments for ME and AMD, 2014 49
Table 6: Product Profile - Lucentis 54
Table 7: Lucentis SWOT Analysis, 2014 59
Table 8: Global Sales Forecast ($m) for Lucentis, 2013-2023 60
Table 9: Surveyed High-Prescribing Physicians (Non-KOLs), by Country 82

1.2 List of Figures

Figure 1: Anatomy of the Eye and Macula 12
Figure 2: Amsler Grid viewed by Patient with Normal Vision and with wAMD 21
Figure 3: Color Fundus Photographs of Dry and Wet AMD 21
Figure 4: FAF Imaging of GA 22
Figure 5: Imaging of wAMD 23
Figure 6: CMT in DME 29
Figure 7: RVOs (BRVO and CRVO) on an FA 30
Figure 8: Increased CRT in ME-RVO 30
Figure 9: ME Clinical Treatment Flowchart 40
Figure 10: AMD Clinical Treatment Flowchart 47

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