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Orencia (abatacept) (Rheumatoid Arthritis) - Forecast and Market Analysis to 2023

Summary

Rheumatoid arthritis (RA) is a chronic autoimmune disease which causes inflammation and deformity of the joints . It affects over seven million individuals in the 10MM covered in this report (US, France, Germany, Italy, Spain, UK, Japan, Australia, China, and India) and the prevalence is expected to grow to just over 8.5 million individuals by 2023. The anti-TNFs have been effective in treating the signs and symptoms of RA and inhibiting progression to erosive bone disease. However, the landscape is quickly changing with the introduction of biosimilars, novel biologics, and a class of oral therapies known as JAK inhibitors, all of which will change the market dynamics between 2013 and 2023. With the anti-TNFs as extremely effective therapies for RA, the market is extremely competitive for new entrants and will undergo further pressure as biosimilars are approved and launch.

BMS’ Orencia (abatacept) is a soluble biologic, and structurally, is a fully-humanized fusion protein of the extracellular domain of the human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), with the Fc domain of human IgG1. The drug functions by preventing T-cell activation. The co-stimulatory molecules CD80 and CD86 are able to bind to CTLA-4, which typically blocks T-cell activation, or to CD28, which activates T cells. Because CTLA-4 has a higher affinity for CD80 and CD86, Orencia is able to block the activation of T cells by competing with CD28 for binding to CD80/CD86.

Scope

- Overview of Rheumatoid Arthritis, including epidemiology, etiology, symptoms, diagnosis, pathology and treatment guidelines as well as an overview on the competitive landscape.
- Detailed information on Orencia (Abatacept) including product description, safety and efficacy profiles as well as a SWOT analysis.
- Sales forecast for Orencia (Abatacept) for the top 9 countries from 2013 to 2023.
- Sales information covered for the US, France, Germany, Italy, Spain, the UK, Japan, Australia and India.

Reasons to buy

- Understand and capitalize by identifying products that are most likely to ensure a robust return.
- Stay ahead of the competition by understanding the changing competitive landscape for Rheumatoid Arthritis.
- Effectively plan your M&A and partnership strategies by identifying drugs with the most promising sales potential.
- Make more informed business decisions from insightful and in-depth analysis of Orencia (Abatacept) performance.
- Obtain sales forecast for Orencia (Abatacept) from 2013-2023 in top 9 countries (the US, France, Germany, Italy, Spain, the UK and Japan, Australia and India).

Table Of Contents

Orencia (abatacept) (Rheumatoid Arthritis) - Forecast and Market Analysis to 2023
1 Table of Contents
2 Introduction 9
2.1 Catalyst 9
2.2 Related Reports 10
3 Disease Overview 13
3.1 Etiology and Pathophysiology 13
3.1.1 Etiology 13
3.1.2 Pathophysiology 13
3.2 Symptoms 18
3.3 Prognosis 19
3.4 Quality of Life 19
4 Disease Management 20
4.1 Diagnosis and Treatment Overview 20
4.1.1 Diagnosis 20
4.1.2 Treatment Guidelines 22
4.1.3 Leading Prescribed Drugs for the Treatment of RA 31
4.1.4 Clinical Practice 33
5 Competitive Assessment 38
5.1 Overview 38
6 Orencia (abatacept) 40
6.1 Overview 40
6.2 Efficacy 42
6.3 Safety 43
6.4 SWOT Analysis 44
6.5 Forecast 45
7 Appendix 46
7.1 Bibliography 46
7.2 Abbreviations 50
7.3 Methodology 53
7.4 Forecasting Methodology 53
7.4.1 Diagnosed RA Patients 53
7.4.2 Percentage of Drug-Treated Patients 54
7.4.3 General Pricing Assumptions 54
7.4.4 Individual Drug Assumptions 55
7.4.5 Generic and Biosimilar Erosion 56
7.5 Primary Research - KOLs Interviewed for This Report 57
7.6 Primary Research - Prescriber Survey 59
7.7 About the Authors 60
7.7.1 Analyst 60
7.7.2 Reviewer 60
7.7.3 Therapy Area Director 61
7.7.4 Global Head of Healthcare 61
7.8 About GlobalData 62
7.9 Disclaimer 62

1.1 List of Tables

Table 1: Symptoms of RA 18
Table 2: 1987 ACR Diagnostic Criteria for RA 21
Table 3: 2010 ACR/EULAR Diagnostic Criteria for RA 22
Table 4: Treatment Guidelines for RA Used by Each Country in the 10MM 24
Table 5: ACR 2012 Criteria for RA Remission and Low/Moderate/High Disease Activity 27
Table 6: EULAR 2013 Criteria for RA Remission 28
Table 7: Most Prescribed Biologics for RA (After csDMARDs) in the Global Markets, 2014 32
Table 8: Leading Branded Treatments for RA 2014 39
Table 9: Product Profile - Orencia 41
Table 10: Orencia SWOT Analysis, 2014 44
Table 11: Global Sales Forecasts ($m) for Orencia, 2013-2023 45
Table 12: High-Prescribing Physicians (non-KOLs) Surveyed, By Country 59

1.2 List of Figures

Figure 1: Normal Synovial Joint and Synovial Joint with RA 14
Figure 2: Cellular and Cytokine Targets for the Current RA Drugs 17
Figure 3: Disease Management Flowchart for Early RA - ACR 2012 28
Figure 4: Disease Management Flowchart for Established RA - ACR 2012 29
Figure 5: Flowchart for the Management of RA - EULAR 2013 30

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