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EpiCast Report: Sepsis - Epidemiology Forecast to 2023

Summary

Sepsis is a life-threatening complication arising from an infection; it occurs when the body’s response to the infection damages its own tissues and organs. Anyone can develop sepsis; however, the condition is more common among children <1 year of age, older adults, and those with weakened immune systems (Mayo Clinic, 2014). Global estimates for the year 2013 showed that there are around 20 to 30 million patients affected by sepsis every year, of which around 8 million patients die (Reinhart et al., 2013).

In the 6MM, the diagnosed incident cases of sepsis will grow from 1,060,052 cases in 2013 to 1,129,816 cases in 2023, at an Annual Growth Rate (AGR) of 0.66% over the forecast period. Throughout the forecast period, the US will have the highest number of diagnosed incident cases of sepsis in the 6MM. the sepsis mortality cases will increase from 439,015 cases in 2013 to 531,282 cases in 2023, at an AGR of 2.10% from 2013 to 2023 in the 6MM. GlobalData epidemiologists attribute the growth in the diagnosed incident cases of sepsis and sepsis mortality cases in the 6MM to changing population demographics in the respective markets.

GlobalData’s epidemiological analysis is supported by the use of country-specific diagnosed incidence and mortality data from epidemiological studies published in peer-reviewed journals. GlobalData epidemiologists used uniform methodology across the 6MM to forecast the diagnosed incident cases of sepsis and sepsis mortality cases to allow for a meaningful comparison of the disease populations across markets.

Scope

- The Sepsis EpiCast Report provides an overview of the risk factors and global trends of sepsis in the 6MM (US, France, Germany, Italy, Spain, and UK). It includes a 10-year epidemiology forecast for the diagnosed incident cases of sepsis segmented by sex, age, severity stage, and causative organism; a 10-year epidemiology forecast for the sepsis mortality cases segmented by sex, age, severity stage, and causative organism. Additionally, the report provides a 10-year epidemiological forecast for the diagnosed incident cases of sepsis that have comorbid conditions disseminated intravascular coagulopathy (DIC), acute respiratory distress syndrome (ARDS), acute lung injury (ALI), and acute kidney injury (AKI) in the 6MM.
- The sepsis epidemiology report is written and developed by Masters- and PhD-level epidemiologists.
- The EpiCast Report is in-depth, high quality, transparent and market-driven, providing expert analysis of disease trends in the 6MM.

Reasons to buy

- Develop business strategies by understanding the trends shaping and driving the global sepsis market.
- Quantify patient populations in the global sepsis market to improve product design, pricing, and launch plans.
- Organize sales and marketing efforts by identifying the age groups and sex that present the best opportunities for sepsis therapeutics in each of the markets covered.
- Identify the percentage of sepsis incident and mortality cases by severity stage and causative organism.

Table Of Contents

EpiCast Report: Sepsis - Epidemiology Forecast to 2023
1 Table of Contents
2 Introduction 8
2.1 Catalyst 8
2.2 Related Reports 9
2.3 Upcoming Reports 9
3 Epidemiology 10
3.1 Disease Background 10
3.2 Risk Factors and Comorbidities 11
3.3 Global Trends 12
3.3.1 US 12
3.3.2 5EU 12
3.4 Forecast Methodology 13
3.4.1 Sources Used 18
3.4.2 Forecast Assumptions and Methods - Diagnosed Incident Cases of Sepsis 24
3.4.3 Forecast Assumptions and Methods - Sepsis Mortality Cases 26
3.4.4 Forecast Assumptions and Methods - Diagnosed Incident Cases of Sepsis by Severity 27
3.4.5 Forecast Assumptions and Methods - Sepsis Mortality Cases by Severity 28
3.4.6 Forecast Assumptions and Methods - Diagnosed Incident Cases of Sepsis by Causative Organism 29
3.4.7 Forecast Assumptions and Methods - Sepsis Mortality Cases by Causative Organism 31
3.4.8 Forecast Assumptions and Methods - Diagnosed Incident Cases of Sepsis by Comorbid Conditions 32
3.5 Epidemiological Forecast for Sepsis (2013-2023) 34
3.5.1 Diagnosed Incident Cases of Sepsis 34
3.5.2 Age-Specific Diagnosed Incident Cases of Sepsis 35
3.5.3 Sex-Specific Diagnosed Incident Cases of Sepsis 37
3.5.4 Sepsis Mortality Cases 39
3.5.5 Age-Specific Sepsis Mortality Cases 41
3.5.6 Sex-Specific Sepsis Mortality Cases 42
3.5.7 Diagnosed Incident Cases of Sepsis by Severity 44
3.5.8 Sepsis Mortality Cases by Severity 46
3.5.9 Diagnosed Incident Cases of Sepsis by Causative Organism 48
3.5.10 Sepsis Mortality Cases by Causative Organism 50
3.5.11 Diagnosed Incident Cases of Sepsis with a Comorbid Condition 52
3.6 Discussion 54
3.6.1 Epidemiological Forecast Insight 54
3.6.2 Limitations of the Analysis 54
3.6.3 Strengths of the Analysis 56
4 Appendix 57
4.1 Bibliography 57
4.2 About the Authors 60
4.2.1 Epidemiologists 60
4.2.2 Reviewers 60
4.2.3 Global Director of Therapy Analysis and Epidemiology 62
4.2.4 Global Head of Healthcare 62
4.3 About GlobalData 63
4.4 About EpiCast 63
4.5 Disclaimer 64

1.1 List of Tables

Table 1: Comorbid Conditions of Sepsis 11
Table 2: ACCP/SCCM Criteria for Classification of Sepsis by Severity 13
Table 3: 6MM, Sources of Diagnosed Incidence Data of Sepsis 14
Table 4: 6MM, Sources of Mortality Data of Sepsis 14
Table 5: 6MM, Sources of Diagnosed Incidence Data of Sepsis by Severity 15
Table 6: 6MM, Sources of Mortality Data of Sepsis by Severity 15
Table 7: 6MM, Sources of Diagnosed Incidence Data of Sepsis by Causative Organism 16
Table 8: 6MM, Sources of Mortality Data of Sepsis by Causative Organism 16
Table 9: 6MM, Sources of Diagnosed Incident Cases of Sepsis with DIC 16
Table 10: 6MM, Sources of Diagnosed Incident Cases of Sepsis with ARDS 17
Table 11: 6MM, Sources of Diagnosed Incident Cases of Sepsis with ALI 17
Table 12: 6MM, Sources of Diagnosed Incident Cases of Sepsis with AKI 17
Table 13: 6MM, Diagnosed Incident Cases of Sepsis, All Ages, Both Sexes, N, 2013-2023 34
Table 14: 6MM, Diagnosed Incident Cases of Sepsis, by Age, Both Sexes, N, (Row %), 2013 36
Table 15: 6MM, Diagnosed Incident Cases of Sepsis, by Sex, All Ages, N (Row %), 2013 38
Table 16: 6MM, Sepsis Mortality Cases, All Ages, Both Sexes, N, 2013-2023 40
Table 17: 6MM, Sepsis Mortality Cases, by Age, Both Sexes, N, (Row %), 2013 41
Table 18: 6MM, Sepsis Mortality Cases, by Sex, All Ages, N (Row %), 2013 43
Table 19: 6MM, Diagnosed Incident Cases of Sepsis by Severity, All Ages, Both Sexes, N, 2013 45
Table 20: 6MM, Sepsis Mortality Cases by Severity, All Ages, Both Sexes, N, (Row %), 2013 47
Table 21: 6MM, Diagnosed Incident Cases of Sepsis by Causative Organism, All Ages, Both Sexes, N (Row %), 2013 49
Table 22: 6MM, Sepsis Mortality Cases by Causative Organism, All Ages, Both Sexes, N (Row %), 2013 51
Table 23: 6MM, Diagnosed Incident Cases of Sepsis with a Comorbid Condition, All Ages, Both Sexes, N, 2013 53

1.2 List of Figures

Figure 1: 6MM, Diagnosed Incident Cases of Sepsis, All Ages, Both Sexes, N, 2013-2023 35
Figure 2: 6MM, Diagnosed Incident Cases of Sepsis, by Age, Both Sexes, N, 2013 37
Figure 3: 6MM, Diagnosed Incident Cases of Sepsis, by Sex, All Ages, N, 2013 39
Figure 4: 6MM, Sepsis Mortality Cases, All Ages, Both Sexes, N, 2013-2023 40
Figure 5: 6MM, Sepsis Mortality Cases, by Age, Both Sexes, N, 2013 42
Figure 6: 6MM, Sepsis Mortality Cases, by Sex, All Ages, N, 2013 44
Figure 7: 6MM, Diagnosed Incident Cases of Sepsis by Severity, All Ages, Both Sexes, N (Row %), 2013 46
Figure 8: 6MM, Sepsis Mortality Cases by Severity, All Ages, Both Sexes, N, 2013 48
Figure 9: 6MM, Diagnosed Incident Cases of Sepsis by Causative Organism, All Ages, Both Sexes, N, 2013 50
Figure 10: 6MM, Sepsis Mortality Cases by Causative Organism, All Ages, Both Sexes, N, 2013 52
Figure 11: 6MM, Diagnosed Incident Cases of Sepsis with a Comorbid Condition, All Ages, Both Sexes, N, 2013 53

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