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MediPoint: Prosthetic Heart Valves - Global Analysis and Market Forecasts

Summary

The global prosthetic heart valves (PHV) market is a dynamic, billion-dollar market that is expected to grow through 2020. Recent advancements in the field of interventional cardiology have greatly improved clinical outcomes for patients. Prosthetic heart valves, including mechanical valves, tissue valves, and transcatheter valves, can be used to treat patients with valvular heart disease affecting the aortic or mitral valves. They can be delivered either via open-heart surgery or transcatheter aortic valve implantation (TAVR).

The rising prevalence of disease and associated risk factors, an aging population, and improved clinical outcomes with minimally invasive techniques are expected to drive the growth of the global prosthetic heart valve market. Emerging technologies such as repositionable and retrievable transcatheter aortic valves will optimize clinical outcomes for patients. With improvements in the design of transcatheter valves, they have the potential to become the standard of treatment for valvular heart disease in the future.

This report focuses on the global prosthetic heart valves market in the 10 major markets (10MM) (US, France, Germany, Italy, Spain, UK, Japan, China, India, and Brazil) for treating valvular heart disease. This report provides insight into the competitive landscape, the marketed and pipeline products, the current and emerging players, and market analysis of each segment. The report identifies the unmet needs in the market while providing an understanding of physicians’ perceptions and decision-making processes in using and evaluating the adoption of different types of prosthetic heart valves.

Highlights

Key Questions Answered

- What is the current and future prosthetic heart valves market outlook in the developed and emerging markets? What trends are affecting the global market?
- Which are the key, high growth markets that valve manufacturers should expand into? Which markets are growing the fastest, and what are the top-selling products in each segment?
- What are the unmet needs with PHVs currently on the market? How will emerging technologies such as repositionable and retrievable valves fulfill these unmet needs?
- What clinical factors and technical specifications influence a physician to use one type of valve over another? What is physician perception and market outlook of PHV?
- What are the challenges and complications of TAVR that have hindered widespread adoption?
- With developing the next-generation of heart valves, what aspects of the technology are device manufacturers focused on optimizing? How will new entrants impact the global PHV market?

Scope

- Overview of valvular heart disease, including anatomy, epidemiology, pathophysiology, symptoms, diagnosis, and treatment guidelines and modalities.
- Annualized total PHV market revenue by type of valve, direct and indirect costs of disease, procedure trends, and market outlooks by country through 2020.
- Key topics covered include strategic competitor assessment, market characterization, identification of unmet needs, reimbursement and regulatory considerations, evaluating market access in each region covered in the report, and implications of the emerging technologies on the market.
- Pipeline analysis: Comprehensive data split across different stages of development, emerging trends and valve designs in development, including investigation of delivery and deployment methods, materials and coatings used, and sizes available.
- Analysis of the current and future market competition in the global prosthetic heart valve market. Insightful review of the key industry drivers, opportunities, barriers and challenges. Each trend is independently researched to provide qualitative analysis of its implications.

Reasons to buy

- “What Physicians Think” quotes provide a unique insight into how healthcare professionals are reacting to events within the industry, and what their responses could mean for industry strategists. In this report you will understand the perceptions of leading Interventional Cardiologists and Cardiac Surgeons from around the world. This information is essential for all strategic decision makers in every organization allowing them to act on high quality information.

Table Of Contents

MediPoint: Prosthetic Heart Valves - Global Analysis and Market Forecasts
1 Table of Contents
1 Table of Contents 7
1.1 List of Tables 14
1.2 List of Figures 20
2 Introduction 23
2.1 Anatomy 23
2.2 Epidemiology 23
2.3 Related Reports 24
3 Industry Overview 25
3.1 Overview 25
3.1.1 Mechanical Heart Valves 25
3.1.2 Tissue Heart Valves 27
3.1.3 Transcatheter Heart Valves 28
3.2 Indications 29
3.2.1 Valvular Stenosis 29
3.2.2 Valvular Regurgitation 30
3.3 Clinical Presentation 30
3.3.1 Diagnosis 30
3.3.2 Risk Assessment Tools 30
3.4 Clinical Outcomes 32
3.4.1 Treatment Options 32
3.4.2 Life Style Changes 33
3.4.3 Complications 33
3.5 Applications of Technology 34
3.6 Market Access 34
3.6.1 Purchasing Decisions 34
3.7 Influence of Clinical Trials 34
3.8 Brand Loyalty 34
3.9 Adoption 35
3.10 Regulation 36
3.10.1 US 36
3.10.2 5EU 37
3.10.3 APAC 38
3.10.4 South America 41
3.11 Reimbursement 42
3.11.1 US 42
3.11.2 5EU 44
3.11.3 APAC 48
3.11.4 South America 51
3.12 Procedure Trends 52
3.12.1 Global Overview 52
3.12.2 By Country 53
3.13 Regulatory Issues/Recalls 74
3.13.1 Portico TAVR Implants Halted Due to Safety Concerns 74
3.14 MandA, Key Partnerships 74
3.14.1 Licensing Agreement Between Symetis and Endoluminal Sciences 74
3.14.2 Manufacturing Agreement Between Sorin Group and Boston Scientific 74
3.15 Economic Impact 74
3.15.1 Indirect Costs 74
3.15.2 Direct Costs 76
4 Unmet Needs 77
4.1 Delivery and Implantation 77
4.1.1 Mechanism of Deployment 77
4.1.2 Anchoring 77
4.1.3 Retrievability 78
4.1.4 Repositionability 78
4.1.5 Artery Accessibility 78
4.1.6 Rapid Pacing 79
4.1.7 Coronary Ostia Occlusion 80
4.1.8 Motorized Delivery Systems 80
4.2 Performance 81
4.2.1 Durability 81
4.2.2 Thrombogenicity 82
4.2.3 Effective Orifice Area 82
4.2.4 Coefficient of Friction 82
4.3 Crimping 83
4.4 Stenting 83
4.5 Replaceable Leaflets 83
4.6 Embolic Protection 84
4.7 Pacemaker Placement 85
5 Market Opportunity Analysis 86
5.1 Overview 86
5.2 Emerging Markets for TAVR 86
5.3 Increasing Tissue Valve Lifespan 87
5.4 Valve-in-Valve Procedures (Re-replacement) 88
5.5 Transcatheter Mitral Valve Replacement 89
5.6 Balloon Valvuloplasty 90
6 Market Drivers and Barriers 91
6.1 Driver: Rising Disease Prevalence 91
6.2 Driver: Multimodality Imaging 92
6.3 Driver: Alternative Access Routes 93
6.4 Driver: Lower Risk Patient Access 93
6.5 Driver: Patient Demand and Awareness 94
6.6 Driver: Advanced Computational Tools 95
6.7 Driver: Rising Competition and Innovation 95
6.8 Barrier: High Device and Procedure Cost 96
6.9 Barrier: Burden of Rising Regulation 96
6.10 Barrier: Medical Device Excise Tax 97
6.11 Barrier: Proving Long-Term Efficacy 97
6.12 Substitute: Valve Repair 98
6.13 Substitute: Balloon Valvuloplasty 98
7 Competitive Assessment 99
7.1 Overview 99
7.2 Classification Based on Features 99
7.2.1 Mechanical Heart Valves 99
7.2.2 Tissue Heart Valves 102
7.2.3 Transcatheter Heart Valves 105
7.3 Market Dynamics Analysis 106
7.4 Product Profiles 108
7.4.1 Mechanical Heart Valves 108
7.4.2 Tissue Heart Valves 114
7.4.3 Transcatheter Heart Valves 120
8 Pipeline Assessment 134
8.1 Overview 134
8.2 Product Profiles 134
8.2.1 Cytograft Tissue Valve (Cytograft Tissue Engineering) 134
8.2.2 Centera Valve (Edwards Lifesciences) 135
8.2.3 Colibri Heart Valve (Colibri Heart Valve) 136
8.2.4 Cormove (Perouse Medical) 137
8.2.5 Endovalve (Micro Interventional Devices) 138
8.2.6 HLT Transcatheter Valve System (Heart Leaflet Technology) 139
8.2.7 Kalangos Valve (Leman Cardiovascular) 140
8.2.8 Tiara Valve (Neovasc) 141
8.2.9 Trinity Valve (Transcatheter Technologies GmbH) 142
8.2.10 Vanguard Exchangeable Heart Valve System (ValveXchange) 143
9 Clinical Trials to Watch 145
9.1 Overview 145
9.2 CoreValve Evolut R (Medtronic) 145
9.3 TRANSFORM Trial - Intuity Valve System (Edwards Lifesciences) 145
9.4 PROACT Trial - On-X Plus 1.5 Mechanical Heart Valve (On-X Life Technologies) 146
9.5 PARTNER II Trial - Sapien XT (Edwards Lifesciences) 146
9.6 PARTNER III Trial - Sapien 3 (Edwards Lifesciences) 146
9.7 REPRISE III IDE/PMA Trial - Lotus Valve System (Boston Scientific) 147
9.8 SENTINEL-H Trial - Sentinel Cerebral Protection System (Claret Medical) 147
10 Current and Future Players 148
10.1 Overview 148
10.2 Trends in Corporate Strategy 148
10.3 Company Profiles 149
10.3.1 AorTech International 149
10.3.2 Boston Scientific 151
10.3.3 Braile Biomedica 152
10.3.4 CardiAQ Valve Technologies 153
10.3.5 Claret Medical 154
10.3.6 Colibri Heart Valve 155
10.3.7 Cytograft Tissue Engineering 156
10.3.8 Direct Flow Medical 157
10.3.9 Edwards Lifesciences 158
10.3.10 Heart Leaflet Technologies 160
10.3.11 JenaValve Technology 161
10.3.12 Leman Cardiovascular 162
10.3.13 Micro Interventional Devices 163
10.3.14 Neovasc 164
10.3.15 On-X Life Technologies, Inc. 165
10.3.16 Perouse Medical 166
10.3.17 Sorin Group 167
10.3.18 St. Jude Medical 168
10.3.19 Symetis 170
10.3.20 Transcatheter Technologies GmbH 171
10.3.21 TTK Healthcare 172
10.3.22 ValveXchange 173
11 Strategic Competitive Assessment 175
11.1 Company Market Share 175
11.1.1 Global Overview 175
11.1.2 By Region 176
11.1.3 By Country 178
12 Market Outlooks by Market Segment 186
12.1 Market Segment Share 186
12.1.1 Global 186
12.1.2 By Region 187
13 Market Outlooks by Geography 191
13.1 Global Overview 191
13.2 US 195
13.3 France 198
13.4 Germany 202
13.5 Italy 206
13.6 Spain 210
13.7 UK 213
13.8 Japan 217
13.9 China 221
13.10 India 225
13.11 Brazil 229
14 Appendix 233
14.1 Bibliography 233
14.2 Abbreviations 244
14.3 Report Methodology 247
14.3.1 Overview 247
14.3.2 Coverage 247
14.3.3 Secondary Research 247
14.4 Forecasting Methodology 249
14.5 Physicians and Specialists Included in This Study 250
14.6 About the Authors 251
14.6.1 Analysts 251
14.6.2 Global Head of Healthcare 252
14.7 About GlobalData 253
14.8 Disclaimer 253

1.1 List of Tables
Table 1: Overview of Symptoms, Risk Factors, and Treatments 25
Table 2: Evolution of the Mechanical Heart Valve 26
Table 3: Evolution of the Tissue Heart Valve 28
Table 4: Comparison of Surgical and Transcatheter Procedures 29
Table 5: NYHA Functional Classification of Cardiac Disease Patients 31
Table 6: Drug Treatment Paradigm for Aortic Valve Disease 32
Table 7: Regulatory Differences Between the US and EU 37
Table 8: Medicare National Average of Inpatient Hospital Reimbursement for Valve Replacement, 2014-2015 43
Table 9: ICD-9 Coding Guide for Valvular Heart Disease, 2014 44
Table 10: Forecast Indirect National Costs For Aortic Valve Disease in the US ($bn), 2011-2020 75
Table 11: Forecast Indirect National Costs For Aortic Valve Disease in the EU ($bn), 2011-2020 75
Table 12: Minimum Arterial Diameter Required for TAVR Systems 79
Table 13: Global Projected Prevalence of Aortic Stenosis, 2013-2020 91
Table 14: Current Access Routes for Transcatheter Aortic Valve Replacement 93
Table 15: Mechanical Heart Valves, SWOT Analysis, 2014 100
Table 16: Marketed Mechanical Heart Valve Products, 2014 101
Table 17: Tissue Heart Valves, SWOT Analysis, 2014 103
Table 18: Marketed Tissue Heart Valve Products, 2014 104
Table 19: Transcatheter Heart Valves, SWOT Analysis, 2014 105
Table 20: Marketed Transcatheter Heart Valve Products, 2014 106
Table 21: Product Profile - Carbomedics Standard Aortic Mechanical Valve (Sorin Group) 108
Table 22: Carbomedics Standard Aortic Mechanical Valve, SWOT Analysis, 2014 109
Table 23: Product Profile - Open Pivot Mechanical Valve (Medtronic) 110
Table 24: Open Pivot Mechanical Valve, SWOT Analysis, 2014 110
Table 25: Product Profile - On-X Mechanical Heart Valve (On-X Life Technologies) 111
Table 26: On-X Mechanical Heart Valve, SWOT Analysis, 2014 112
Table 27: Product Profile - On-X Plus 1.5 Mechanical Heart Valve (On-X Life Technologies) 112
Table 28: On-X Plus 1.5 Mechanical Heart Valve, SWOT Analysis, 2014 113
Table 29: Product Profile - Regent Valve (St. Jude Medical) 113
Table 30: Regent Valve, SWOT Analysis, 2014 114
Table 31: Product Profile - Carpentier-Edwards Perimount Pericardial Valve (Edwards Lifesciences) 115
Table 32: Carpentier-Edwards Perimount Pericardial Valve, SWOT Analysis, 2014 115
Table 33: Product Profile - 3f Enable Sutureless Aortic Bioprosthesis (Medtronic) 116
Table 34: 3f Enable Sutureless Aortic Bioprosthesis, SWOT Analysis, 2014 116
Table 35: Product Profile - Hancock II (Medtronic) 117
Table 36: Medtronic Hancock II, SWOT Analysis, 2014 117
Table 37: Product Profile - Mitroflow Aortic Pericardial Heart Valve (Sorin Group) 118
Table 38: Sorin Group Mitroflow Aortic Pericardial Heart Valve, SWOT Analysis, 2014 118
Table 39: Product Profile - Trifecta Heart Valve (St. Jude Medical) 119
Table 40: St. Jude Medical Trifecta Heart Valve, SWOT Analysis, 2014 120
Table 41: Product Profile - Acurate TA/Acurate neo (Symetis) 120
Table 42: Acurate TA/Acurate neo, SWOT Analysis, 2014 121
Table 43: Product Profile - Lotus Valve System (Boston Scientific) 122
Table 44: Boston Scientific Lotus Valve System, SWOT Analysis, 2014 123
Table 45: Product Profile - Direct Flow Medical Transcatheter Valve (Direct Flow Medical) 124
Table 46: Direct Flow Medical Valve, SWOT Analysis, 2014 124
Table 47: Product Profile - Sapien XT Valve (Edwards Lifesciences) 125
Table 48: Sapien XT Valve, SWOT Analysis, 2014 126
Table 49: Product Profile - JenaValve (JenaValve Technology) 127
Table 50: JenaValve, SWOT Analysis, 2014 127
Table 51: Product Profile - CoreValve (Medtronic) 128
Table 52: CoreValve, SWOT Analysis, 2014 129
Table 53: Product Profile - CoreValve Evolut R (Medtronic) 130
Table 54: CoreValve Evolut R, SWOT Analysis, 2014 130
Table 55: Product Profile - Portico Valve (St. Jude Medical) 131
Table 56: Portico Valve, SWOT Analysis, 2014 131
Table 57: Product Profile - Inovare Valve (Braile Biomedica) 132
Table 58: Inovare Valve, SWOT Analysis, 2014 133
Table 59: Product Profile - Cytograft Tissue Valve (Cytograft Tissue Engineering) 134
Table 60: Cytograft Tissue Valve, SWOT Analysis, 2014 135
Table 61: Product Profile - Centera Valve (Edwards Lifesciences Corporation) 135
Table 62: Centera Valve, SWOT Analysis, 2014 136
Table 63: Product Profile - Colibri Heart Valve (Colibri Heart Valve) 137
Table 64: Colibri Heart Valve, SWOT Analysis, 2014 137
Table 65: Product Profile - Cormove (Perouse Medical) 138
Table 66: Cormove, SWOT Analysis, 2014 138
Table 67: Product Profile - Endovalve (Micro Interventional Devices) 139
Table 68: Endovalve, SWOT Analysis, 2014 139
Table 69: Product Profile - HLT Transcatheter Valve System (Heart Leaflet Technology) 140
Table 70: HLT Transcatheter Valve System, SWOT Analysis, 2014 140
Table 71: Product Profile - Kalangos Valve (Leman Cardiovascular) 141
Table 72: Kalangos Valve, SWOT Analysis, 2014 141
Table 73: Product Profile - Tiara Valve (Neovasc.) 141
Table 74: Tiara Valve, SWOT Analysis, 2014 142
Table 75: Product Profile - Trinity Valve (Transcatheter Technologies GmbH) 142
Table 76: Trinity VALVE, SWOT Analysis, 2014 143
Table 77: Product Profile - Vanguard Exchangeable Heart Valve System (ValveXchange) 144
Table 78: Vanguard Exchangeable Heart Valve System, SWOT Analysis, 2014 144
Table 79: AorTech International plc, Company Profile, 2014 150
Table 80: AorTech International, SWOT Analysis, 2014 150
Table 81: Boston Scientific Corporation, Company Profile, 2014 151
Table 82: Boston Scientific Corporation, SWOT Analysis, 2014 152
Table 83: Braile Biomedica, Company Profile, 2014 153
Table 84: Braile Biomedica, SWOT Analysis, 2014 153
Table 85: CardiAQ Valve Technologies, Company Profile, 2014 154
Table 86: CardiAQ Valve Technologies, SWOT Analysis, 2014 154
Table 87: Claret Medical, Inc., Company Profile, 2014 155
Table 88: Claret Medical, SWOT Analysis, 2014 155
Table 89: Colibri Heart Valve, LLC, Company Profile, 2014 156
Table 90: Colibri Heart Valve, SWOT Analysis, 2014 156
Table 91: Cytograft Tissue Engineering, Inc., Company Profile, 2014 157
Table 92: Cytograft Tissue Engineering, SWOT Analysis, 2014 157
Table 93: Direct Flow Medical, Inc., Company Profile, 2014 158
Table 94: Direct Flow Medical, SWOT Analysis, 2014 158
Table 95: Edwards Lifesciences Corporation, Company Profile, 2014 159
Table 96: Edwards Lifesciences, SWOT Analysis, 2014 160
Table 97: Heart Leaflet Technologies, Company Profile, 2014 160
Table 98: Heart Leaflet Technologies, SWOT Analysis, 2014 161
Table 99: JenaValve Technology, Company Profile, 2014 161
Table 100: JenaValve Technology, SWOT Analysis, 2014 162
Table 101: Leman Cardiovascular, Company Profile, 2014 162
Table 102: Leman Cardiovascular, SWOT Analysis, 2014 163
Table 103: Micro Interventional Devices, Inc., Company Profile, 2014 163
Table 104: Micro Interventional Devices, SWOT Analysis, 2014 164
Table 105: Neovasc, Inc., Company Profile, 2014 164
Table 106: Neovasc, SWOT Analysis, 2014 165
Table 107: On-X Life Technologies, Inc., Company Profile, 2014 165
Table 108: On-X Life Technologies, SWOT Analysis, 2014 166
Table 109: Perouse Medical, Company Profile, 2014 166
Table 110: Perouse Medical, SWOT Analysis, 2014 167
Table 111: Sorin Group, Company Profile, 2014 167
Table 112: Sorin Group, SWOT Analysis, 2014 168
Table 113: St. Jude Medical, Inc., Company Profile, 2014 169
Table 114: St. Jude Medical, Inc., SWOT Analysis, 2014 169
Table 115: Symetis, Company Profile, 2014 170
Table 116: Symetis, SWOT Analysis, 2014 170
Table 117: Transcatheter Technologies GmbH, Company Profile, 2014 171
Table 118: Transcatheter Technologies, SWOT Analysis, 2014 171
Table 119: TTK Healthcare, Company Profile, 2014 172
Table 120: TTK Healthcare, SWOT Analysis, 2014 172
Table 121: ValveXchange, Inc., Company Profile, 2014 173
Table 122: ValveXchange, SWOT Analysis, 2014 174
Table 123:Global Market Value Forecast by Market Segment for Prosthetic Heart Valves, $m, 2011-2020 187
Table 124:5EU Market Value Forecast by Market Segment for Prosthetic Heart Valves, $m, 2011-2020 188
Table 125:APAC Market Value Forecast by Market Segment for Prosthetic Heart Valves, $m, 2011-2020 190
Table 126:US Market Value Forecast by Market Segment for Prosthetic Heart Valves, $m, 2011-2020 196
Table 127:France Market Value Forecast by Market Segment for Prosthetic Heart Valves, $m, 2011-2020 199
Table 128:Germany Market Value Forecast by Market Segment for Prosthetic Heart Valves, $m, 2011-2020 203
Table 129:Italy Market Value Forecast by Market Segment for Prosthetic Heart Valves, $m, 2011-2020 207
Table 130:Spain Market Value Forecast by Market Segment for Prosthetic Heart Valves, $m, 2011-2020 211
Table 131:UK Market Value Forecast by Market Segment for Prosthetic Heart Valves, $m, 2011-2020 214
Table 132:Japan Market Value Forecast by Market Segment for Prosthetic Heart Valves, $m, 2011-2020 218
Table 133:China Market Value Forecast by Market Segment for Prosthetic Heart Valves, $m, 2011-2020 222
Table 134:India Market Value Forecast by Market Segment for Prosthetic Heart Valves, $m, 2011-2020 226
Table 135:Brazil Market Value Forecast by Market Segment for Prosthetic Heart Valves, $m, 2011-2020 230

1.2 List of Figures
Figure 1: Hierarchy of Valvular Heart Disease 29
Figure 2: Operative Risk for Severe, Symptomatic Aortic Valve Disease Patients, 2009 36
Figure 3: US Procedure Volume Forecast by Market Segment, 2011-2020 54
Figure 4: US Procedure Volume Comparison by Market Segment, 2013 and 2020 55
Figure 5: France Procedure Volume Forecast by Market Segment, 2011-2020 56
Figure 6: France Procedure Volume Comparison by Market Segment, 2013 and 2020 57
Figure 7: Germany Procedure Volume Forecast by Market Segment, 2011-2020 58
Figure 8: Germany Procedure Volume Comparison by Market Segment, 2013 and 2020 59
Figure 9: Italy Procedure Volume Forecast by Market Segment, 2011-2020 60
Figure 10: Italy Procedure Volume Comparison by Market Segment, 2013 and 2020 61
Figure 11: Spain Procedure Volume Forecast by Market Segment, 2011-2020 62
Figure 12: Spain Procedure Volume Comparison by Market Segment, 2013 and 2020 63
Figure 13: UK Procedure Volume Forecast by Market Segment, 2011-2020 64
Figure 14: UK Procedure Volume Comparison by Market Segment, 2013 and 2020 65
Figure 15: Japan Procedure Volume Forecast by Market Segment, 2011-2020 66
Figure 16: Japan Procedure Volume Comparison by Market Segment, 2013 and 2020 67
Figure 17: China Procedure Volume Forecast by Market Segment, 2011-2020 68
Figure 18: China Procedure Volume Comparison by Market Segment, 2013 and 2020 69
Figure 19: India Procedure Volume Forecast by Market Segment, 2011-2020 70
Figure 20: India Procedure Volume Comparison by Market Segment, 2013 and 2020 71
Figure 21: Brazil Procedure Volume Forecast by Market Segment, 2011-2020 72
Figure 22: Brazil Procedure Volume Comparison by Market Segment, 2013 and 2020 73
Figure 23: Global Company Market Shares for Prosthetic Heart Valves, 2012 175
Figure 24: EU Company Market Share for Prosthetic Heart Valves, 2012 177
Figure 25: APAC Company Market Shares for Prosthetic Heart Valves, 2012 178
Figure 26: US Company Market Shares for Prosthetic Heart Valves, 2012 179
Figure 27: France Company Market Shares for Prosthetic Heart Valves, 2012 179
Figure 28: Germany Company Market Shares for Prosthetic Heart Valves, 2012 180
Figure 29: Italy Company Market Shares for Prosthetic Heart Valves, 2012 181
Figure 30: Spain Company Market Shares for Prosthetic Heart Valves, 2012 181
Figure 31: UK Company Market Shares for Prosthetic Heart Valves, 2012 182
Figure 32: Japan Company Market Shares for Prosthetic Heart Valves, 2012 183
Figure 33: China Company Market Shares for Prosthetic Heart Valves, 2012 183
Figure 34: India Company Market Shares for Prosthetic Heart Valves, 2012 184
Figure 35: Brazil Company Market Shares for Prosthetic Heart Valves, 2012 185
Figure 36: Global Market Value Forecast by Market Segment for Prosthetic Heart Valves, $m, 2011-2020 186
Figure 37: 5EU Market Value Forecast by Market Segment for Prosthetic Heart Valves, 2011-2020 188
Figure 38: APAC Market Value Forecast by Market Segment for Prosthetic Heart Valves, 2011-2020 189
Figure 39: Global Sales Volume for Prosthetic Heart Valves, Number of Units, 2011-2020 191
Figure 40: Global Market Value Forecast by Country, $m, 2011-2020 192
Figure 41: Global Market Share Comparison by Country, 2013 and 2020 194
Figure 42: US Market Value Forecast by Market Segment, $m, 2011-2020 195
Figure 43: US Market Value Comparison by Market Segment, 2013 and 2020 197
Figure 44: US Average Selling Price by Market Segment, 2011-2020 198
Figure 45: France Market Value Forecast by Market Segment, $m, 2011-2020 199
Figure 46: France Market Value Comparison by Market Segment, 2013 and 2020 201
Figure 47: France Average Selling Price by Market Segment, 2011-2020 202
Figure 48: Germany Market Value Forecast by Market Segment, $m, 2011-2020 203
Figure 49: Germany Market Value Comparison by Market Segment, 2013 and 2020 205
Figure 50: Germany Average Selling Price by Market Segment, 2011-2020 206
Figure 51: Italy Market Value Forecast by Market Segment, $m, 2011-2020 207
Figure 52: Italy Market Value Comparison by Market Segment, 2013 and 2020 208
Figure 53: Italy Average Selling Price by Market Segment, 2011-2020 209
Figure 54: Spain Market Value Forecast by Market Segment, $m, 2011-2020 210
Figure 55: Spain Market Value Comparison by Market Segment, 2013 and 2020 212
Figure 56: Spain Average Selling Price by Market Segment, 2011-2020 213
Figure 57: UK Market Value Forecast by Market Segment, $m, 2011-2020 214
Figure 58: UK Market Value Comparison By Market Segment, 2013 and 2020 216
Figure 59: UK Average Selling Price by Market Segment, 2011-2020 217
Figure 60: Japan Market Value Forecast by Market Segment, $m, 2011-2020 218
Figure 61: Japan Market Value Comparison by Market Segment, 2013 and 2020 220
Figure 62: Japan Average Selling Price by Market Segment, 2011-2020 221
Figure 63: China Market Value Forecast by Market Segment, $m, 2011-2020 222
Figure 64: China Market Value Comparison by Market Segment, 2013 and 2020 224
Figure 65: China Average Selling Price by Market Segment, 2011-2020 225
Figure 66: India Market Value Forecast by Market Segment, $m, 2011-2020 226
Figure 67: India Market Value Comparison by Market Segment, 2013 and 2020 228
Figure 68: India Average Selling Price by Market Segment, 2011-2020 229
Figure 69: Brazil Market Value Forecast by Market Segment, $m, 2011-2020 230
Figure 70: Brazil Market Value Comparison by Market Segment, 2013 and 2020 231
Figure 71: Brazil Average Selling Price by Market Segment, 2011-2020 232

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