1. Market Research
  2. > Pharmaceutical
  3. > Therapy Market Trends
  4. > A Competitive Analysis of the Global Acute Coronary Syndrome (ACS) Therapeutics Market

Launch of Promising Late-stage Anti-hypertensive Drugs to Drive Growth of Branded ACS Therapeutics

This research service offers an assessment for marketed and pipeline products for the global ACS therapeutics market. Segmentation by drug class is provided along with additional supporting information such as clinical trial timelines and results, historical and projected launch timelines, and epidemiology. The marketed and pipeline products are broadly segmented into anti-platelet therapeutics, anti-hypertensives and cholesterol lowering drugs, anti-thrombins, and others. Other upcoming therapies include anti-inflammatories. The forecast period is 2015–2025.

Executive Summary—Key Findings
- The ACS therapeutics market is comprised of both branded and generics drugs, the latter of which registers the most revenue.
- The market is driven by the ageing population and a prevalence of conditions associated with unhealthy living such as obesity and metabolic disorders such as diabetes.
- There are approximately key marketed branded drugs and hundreds of generics indicated for the treatment of ACS. The current treatments increasingly focus on targeting novel orphan pathways for treatment of ACS and to augment the existing class of therapeutics.
- These new drug classes are being evaluated to merge various unmet gaps among patients such as statin intolerance, bleeding risks associated with existing blood thinning drugs, and an effective treatment of atherosclerotic plaques.
- Among the various classes of ACS therapeutics, anti-hypertensives and cholesterol lowering drugs are currently dominating the ACS therapeutics market with an influx of new drugs targeting novel pathways.
The key drug targets include the proprotein convertase subtilisin/kexin type 9 (PCSK9) and cholesteryl ester transfer protein (CETP).
- The next 5 years are expected to witness the launch of the key drugs Losmapimod (GSK), Praluent (Sanofi & Regeneron), Anacetrapib (Merck & Co.), Evacetrapib (Eli Lilly and Co.), and Evolocumab (Amgen), which will boost market share for branded drugs to approximately %.
o Losmapimod from GSK’s drug portfolio is an anti-inflammatory drug which inhibits the p38 mitogen activated protein kinase (MAPK) and is being evaluated in Phase clinical trials (LATITUDE-TIMI 60).
o Amgen’s Repatha (Evolocumab) Phase 3 clinical trial program PROFICIO has engaged patients for testing the LDL-C and cardiovascular outcomes following inhibition of PCSK9 in different populations. Nearly 10 clinical phase trials are being conducted under this Phase 3 trial program.
- The drug was designed to inhibit PCSK9 from binding to LDL receptors on the liver’s surface. In the absence of PCSK9, enough LDL receptors will not be present on the surface of the liver to remove LDL-C from the blood.
o GSK has so far recruited patients for this trials to evaluate the safety of the drug in reducing the risk of cardiovascular events such as death, heart attack, or near heart attack that require urgent treatment. The enzyme p38 kinase is known for its role in inflammation and its inhibition is expected to stabilize atherosclerotic plaques and reduce plaque rupture thereby preventing thrombosis.
o The drug Evolocumab combined with the standard care treatment benefitted the patients by reducing the LDL-c by % when compared to standard of care treatment alone.
o Sanofi and Regeneron has recently received a priority review certificate for its lead drug Praluent (alirocumab) an investigational monoclonal antibody targeting PCSK9 (proprotein convertase subtilisin/kexin type 9). So far, ten Phase 3 clinical trials, including ODYSSEY OUTCOMES, will include over patients.
o Anacetrapib is being developed by Merck for treatment of hypercholesterolemia and prevention of cardiovascular disease. It has engaged over 30,000 participants in a randomized double-blinded, placebo-controlled trial code named REVEAL and DEFINE Phase 3 trials. The drug is a CETP inhibitor.
- The market size of the ACS therapeutics was approximately $ billion in 2014 and is expected to reach $ billion in 2019 growing at a CAGR of %.

Table Of Contents

A Competitive Analysis of the Global Acute Coronary Syndrome (ACS) Therapeutics Market
1. EXECUTIVE SUMMARY

Executive Summary
Executive Summary—Key Findings
Key Trends
Companies to Watch

2. METHODOLOGY AND SCOPE

Methodology and Scope

3. MARKET OVERVIEW

Market Overview
Market Overview—Introduction
Market Overview—Epidemiology

4. PHYSICIANS TREATMENT GUIDELINES

Physicians Treatment Guidelines
Market Size
Market Size—Segmentation
Market Forecast
Market Segmentation

5. COMPETITIVE LANDSCAPE—ACS THERAPEUTICS (MARKETED AND PIPELINE PRODUCTS)

Competitive Landscape—ACS Therapeutics (Marketed and Pipeline Products)
Competitive Landscape Overview
Competitive Landscape—Marketed and Pipeline Products
Marketed Products—Anti-platelet Therapy
Pipeline Products—Anti-platelet Therapy
Marketed Products—Anti-thrombin Therapy
Pipeline Products—Anti-thrombin Therapy
Marketed Products—Anti-hypertensives and Cholesterol Lowering Drugs
Pipeline Products—Anti-hypertensives and Cholesterol Lowering Drugs
Pipeline Products—Others
Product Launch Timeline
Patent Expirations

6. PIVOTAL PHASE 3 TRIALS

Pivotal Phase 3 Trials
ACS Therapeutics—Major Ongoing/Recently Completed Clinical Trials
Summary of Key Products to Watch

7. PRODUCT DASHBOARD (KEY MARKETED AND PHASE 3 PRODUCTS)

Product Dashboard (Key Marketed and Phase 3 Products)
Product Dashboard: Plavix (clopidogrel)—Bristol-Myers Squibb
Product Dashboard: Brilinta (ticagrelor)—The Medicines Company
Product Dashboard: Angiomax—The Medicines Company
Product Dashboard: Zocor (simvastatin)—Merck
Product Dashboard: Xarelto (rivaroxaban)—Bayer
Product Dashboard: Alirocumab (RGN727)—Sanofi and Regeneron
Product Dashboard: Evolocumab (Repatha)—Amgen
Product Dashboard: Evacetrapib—Eli Lilly and Company
Product Dashboard: Losmapimod—GSK

8. CONCLUSION

Conclusion
Conclusions
Legal Disclaimer

9. APPENDIX

Appendix
Decision Support Database

10. THE FROST and SULLIVAN STORY

The Frost and Sullivan Story
Value Proposition—Future of Your Company and Career
Global Perspective
Industry Convergence
360º Research Perspective
Implementation Excellence
Our Blue Ocean Strategy

View This Report »

Get Industry Insights. Simply.

  • Latest reports & slideshows with insights from top research analysts
  • 24 Million searchable statistics with tables, figures & datasets
  • More than 10,000 trusted sources
24/7 Customer Support

Talk to Veronica

+1 718 514 2762

Purchase Reports From Reputable Market Research Publishers
PharmaPoint: Attention Deficit Hyperactivity Disorder (ADHD) - Global Drug Forecast and Market Analysis to 2024

PharmaPoint: Attention Deficit Hyperactivity Disorder (ADHD) - Global Drug Forecast and Market Analysis to 2024

  • $ 10995
  • Industry report
  • September 2016
  • by Global Data

PharmaPoint: Attention Deficit Hyperactivity Disorder (ADHD) - Global Drug Forecast and Market Analysis to 2024 Summary Attention deficit hyperactivity disorder (ADHD) is characterized by excessive levels ...

Ulcerative Colitis: KOL Insight

Ulcerative Colitis: KOL Insight

  • $ 8085
  • Industry report
  • September 2016
  • by Firstword Pharma

Are UC biosimilars a real or perceived threat to branded drugs? Ulcerative colitis (UC) treatment is on the brink. Patents are ending on various branded drugs and clearing the way for an influx of biosimilars; ...

Colorectal Cancer KOL Insight 2016

Colorectal Cancer KOL Insight 2016

  • $ 8085
  • Industry report
  • October 2016
  • by Firstword Pharma

KOLs embrace novel MoAs as low survival rates drive search for new treatments Faced with persistently low survival rates, KOLs are calling for new approaches to treat late-stage colorectal cancer (CRC). ...

Hepatitis C: Kol Insight

September 2016 $ 8085

ref:plp2015

Reportlinker.com © Copyright 2016. All rights reserved.

ReportLinker simplifies how Analysts and Decision Makers get industry data for their business.