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Cell Culture: The Market for Media, Sera and Reagents

  • May 2015
  • -
  • Kalorama Information
  • -
  • 170 pages

This Kalorama Information report, Cell Culture; The Market for Media, Sera and Reagents, analyzes the world market for media, sera and reagents and the major trends and drivers. It is the fifth time Kalorama Information has looked at this market since 2007.

As growing cells for biopharmaceutical production is slow, expensive and complicated, optimizing cell culture development is of paramount concern to companies developing biopharmaceuticals. The report contains market size projections, product offerings of major companies, current culture practice trends and company market share. The report focuses on three segments of the cell culture market: media, sera and reagents.

Table Of Contents

Cell Culture: The Market for Media, Sera and Reagents
CHAPTER ONE: EXECUTIVE SUMMARY
Scope and Methodology
Cells for Biopharmaceutical Production
Bacteria and Yeasts Systems
Animal Cell Systems
Insect Cell Systems
Cell Lines and Cell Banks
Fermentors and Bioreactors
Stirred-tank Reactors
Airlift Fermentors
Packed Bed Reactors
Hollow-fiber Reactor
Single-use Disposable Systems
Perfusion Bioreactor
Fermentation Processes
Batch and Fed-Batch Fermentation
Suspended vs. Anchored Cells
Microencapsulation
Advancement In Cell Culture Techniques: 3d Cell Culture
Growing cells in three dimensional systems
Cell Culture Environment
Functions and Components of Basal Media
pH and Osmotic Pressure
Energy Sources
Nutrients
Cell Culture Media
Lysogeny broth (LB)
Classical Media
Serum-free Media
Protein-free Media
Chemically Defined Media
Specialty Media
Sera
Reagents
Shifting Towards Non-animal Derived Reagents
Addressing Reagent Safety Issues
Global Cell Culture Market
Cell Culture Market and Forecast
Current and Future Trends
CHAPTER TWO: INTRODUCTION
Growing Demand for Biopharmaceuticals
Biopharmaceutical Growth Increases Demand for Cell Culture Products
A Brief History of Biotechnology
Science of Genetic Manipulation
Biopharmaceutical Market and Production
Biopharmaceutical Production
Top Selling Biopharmaceuticals in 2012, 2013 and 2014
FDA-approved Biopharmaceuticals
Upstream Bioprocessing: Cell Culture Expression Systems
Cells for Biopharmaceutical Production
Bacteria and Yeasts Systems
Animal Cell Systems
Insect Cell Systems
Advantages/Disadvantages of Cell Culture Systems
Cell Lines and Cell Banks
Biopharmaceuticals Produced from Cell Culture
Cell Culture Practices/Guidelines
Validation of Facilities
Maintaining Sterilization Standards
CHAPTER THREE: TECHNOLOGY
Introduction and Overview
Milestones in Cell Culture Development
Cell Lines for Bioproduction
Predominant Cell Lines
Chinese Hamster Ovary (CHO)
SP2/0, and NS0
HEK 293 and PER. C6
Sources: Largest Collections of Cell Lines
Bioreactors
Types of Bioreactors/Fermentors
Stirred-tank Reactors
Airlift Fermentors
Packed Bed Reactors
Hollow-fiber Reactor
Single-use/Disposable Systems
Perfusion Bioreactor
Fermentation Processes
Batch and Fed-Batch Fermentation
Suspended vs. Anchored Cells
Microencapsulation
Advancement In Cell Culture Techniques: 3d Cell Culture
Growing Cells in Three Dimensional Systems
Functions and Components of Basal Media
pH and Osmotic Pressure
Energy Sources
Nutrients
Cell Culture Media
Types of Media
Lysogeny broth (LB)
Classical Media
Serum-free Media
Protein-free Media
Chemically Defined Media
Specialty Media
Sera
Sources of Sera
Bovine Serum Safety Issues and Regulations
Shift to Serum-free Media
Reagents
Major Types of Biologic Reagents
Amino Acids
Growth Factors and Cytokines
Albumin
Transferrin
Thrombin
Growth Supplements
Protease Inhibitor
Attachment Factors
Shifting Towards Non-animal Derived Reagents
Addressing Reagent Safety Issues
CHAPTER FOUR: CELL CULTURE MARKET
Overview
Cell Culture Market
Market Drivers
Cell Culture Market Forecast
Global Cell Culture Market Share, by Region
Global Market Share, by Region, 2014 and 2019
Asia Pacific Region Gaining Market Share
Singapore: Fastest Growing Region
Market Segment Analysis
Media
Percentage of Market by Media Type
Advantages and Disadvantages of Using Serum
Liquid Versus Powdered Media
Sera
Reagents
Reagent Types
Cytokines and growth factors
Cell Dissociation Reagents
Buffers and Salt Solutions
Other Reagents
Cell Culture Supplier Market Share
Market Leaders in Cell Culture, 2014
Current and Future rends
Shift to Serum-free and Animal Product-free Media
Cell Culture-based Vaccine Production
Cell Culture-based Seasonal Vaccines
Stem Cell Research Driving Cell Culture Market
Sigma-Aldrich
ThermoFisher Scientific
Lonza Bioscience
EMD Millipore
BD Bioscience
Impact of Generic Biopharmaceuticals on Cell Culture Market
CHAPTER FIVE: COMPANY PROFILES
Advanced Biotechnologies, Inc.
History and Lines of Business
Cell Culture Products and Services
Affymetrix, Inc
History and Lines of Business
Cell Culture Products, Reagents and Biochemicals
AMRESCO, Inc.
History and Lines of Business
Cell Culture Products
Analytical Biological Services Inc.
History and Lines of Business
Cell Culture Products
Atlanta Biologicals, Inc.
History and Lines of Business
Cell Culture Products
Athena Enzyme Systems
History and Lines of Business
Cell Culture Products
BD Biosciences
History and Lines of Business
Cell Culture Products
Bioreclamation Inc
History and Lines of Business
Cell Culture Products
Cell Essentials, Inc.
History and Lines of Business
Cell Culture Products
CellGenix Technologie Transfer GmbH
History and Lines of Business
Cell Culture Products and Services
ClonTech Laboratories, inc.
History and Lines of Business
Cell Culture Products
Corning Life Sciences
History and Lines of Business
Cell Culture Products
EMD Millipore
History and Lines of Business
Cell Culture Products
GE Heathcare Live Sciences
History and Lines of Business
Cell Culture Products
Gemini Bio-Products
History and Lines of Business
Cell Culture Products
invitria
History and Lines of Business
Cell Culture Products
Irvine Scientific
History and Lines of Business
Cell Culture Products
J R Scientific, Inc.
History and Development
Cell Culture Products
Life Technologies
History and Lines of Business
Cell Culture Products
Lonza Bioscience
History and Lines of Business
Cell Culture Products and Services
MP Biomedicals
History and Lines of Business
Cell Culture Products
Novozymes Biopharma US Inc
History and Lines of Business
Cell Culture Products
PromoCell GmbH
History and Lines of Business
Cell Culture Products
Quality Biological, Inc.
History and Lines of Business
Cell Culture Products
RandD Systems, Inc
History and Lines of Business
Cell Culture Products
SBH Sciences
History and Lines of Business
Cell Culture Products
Selexis SA
History and Lines of Business
Cell Culture Products and Technology
SeraCare Life Sciences, Inc.
History and Lines of Business
Cell Culture Products
Sera Laboratories International Ltd
History and Lines of Business
Cell Culture Products
Product Categories
Sigma-Aldrich
History and Lines of Business
Cell Culture Products
Stemcell Technologies Inc.
History and Lines of Business
Cell Culture Products
Thermo Fisher Scientific, Inc.
History and Lines of Business
Cell Culture Products
Tico Europe
History and Lines of Business
Cell Culture Products
Wisent Bioproducts
History and Lines of Business
Cell Culture Products
TABLE OF EXHIBITS
CHAPTER ONE: EXECUTIVE SUMMARY
Exhibit 1-1: Global Cell Culture Market, 2009-2019
Exhibit 1-2: Cell Culture Global Market Share, 2014 (North America, UK/Ireland, Rest of Europe,
China, Japan, Korea, Singapore/Malaysia, ROW)
CHAPTER TWO: INTRODUCTION
Exhibit 2-1: Top Selling Biological Drugs in 2012 and 2013
Exhibit 2-2: Top Selling Biological Drugs in 2014
Exhibit 2-3: FDA Biopharmaceutical Product Approvals, 2013
Exhibit 2-4: FDA Biopharmaceutical Product Approvals, 2014
Exhibit 2-5: Approximate times from Introduced Gene to Protein Production at Useable Levels
Exhibit 2-6: Disadvantages/Advantages of Cell Culture Systems
Exhibit 2-7: Selected Biopharmaceuticals Produced from Bacteria, Yeast and Mammalian Cells
CHAPTER THREE: TECHNOLOGY
Table 3-1: Five Types of 3D Cell Culture Methods
Exhibit 3-2: Selected Products/Companies Offering Alternatives to Animal Sera Products for Hybridoma,Myeloma and CHO cell lines
CHAPTER FOUR: MARKET ANALYSIS
Exhibit 4-1: Global Cell Culture Market, 2009-2019
Exhibit 4-2: Cell Culture Global Market Share, by Region, 2014 (North America, UK/Ireland, Rest of
Europe, China, Japan, Korea, Singapore/Malaysia, ROW)
Exhibit 4-3: Cell Culture Global Market Share, by Region, 2019
Exhibit 4-4: Global Market Share, 2014 and 2019
Exhibit 4-5: Global Cell Culture Market by Segment Media, Sera and Reagents, 2009-2019
Exhibit 4-6 Media Sales, 2014-2019
Exhibit 4-7 Market Share, by Media Type, 2014 (Animal-Free, Serum-Free, Chemically Defined)
Exhibit 4-8: Market Share, by Media Type, 2019 (Animal-Free, Serum-Free, Chemically Defined)
Exhibit 4-10: Sera Sales, 2009-2019
Exhibit 4-11: Market Share by 2014 by Sera Type(Newborn Calf, Other Bovine, Other Sera, Fetal Bovine Serum)
Exhibit 4-12: Reagent Sales, 2009-2019
Table 4-13: Market Share by Reagent Type, 2014 (Buffers and Salt Solution, Cytokines and Growth Factors, Cell Dissociation Reagents, Buffers and Salt Solutions, Others)
Exhibit 4-14: Cell Culture Company Market Share 2014




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