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Global Medical Adhesives and Sealant Industry

  • March 2016
  • -
  • Global Industry Analysts
  • -
  • 326 pages

This report analyzes the worldwide markets for Medical Adhesives and Sealants in US$ Thousand by the following Product Group/Segments: Synthetic Adhesives & Sealants (Acrylic, Cyanoacrylate, Silicone, & Others), and Natural Adhesives & Sealants (Albumin, Collagen, Fibrin, & Others). Further, the market is also analyzed by the following Applications: Dental, and Medical. The report provides separate comprehensive analytics for the US, Canada, Japan, Europe, Asia-Pacific, Latin America, and Rest of World. Annual estimates and forecasts are provided for the period 2015 through 2022. Also, a six-year historic analysis is provided for these markets. Market data and analytics are derived from primary and secondary research. Company profiles are primarily based on public domain information including company URLs. The report profiles 63 companies including many key and niche players such as -

3M Company
Adhesives Research, Inc.
Advanced Medical Solutions Group plc
B. Braun Melsungen AG
Baxter International, Inc.

Table Of Contents

Global Medical Adhesives and Sealant Industry


I. INTRODUCTION, METHODOLOGY and PRODUCT DEFINITIONS

Study Reliability and Reporting Limitations I-1 Disclaimers.............. I-2 Data Interpretation and Reporting Level I-2 Quantitative Techniques and Analytics I-3 Market Definitions and Scope of Study I-3

II. EXECUTIVE SUMMARY

1. INDUSTRY OVERVIEW.............. II-1 Medical Adhesives and Sealants Play An Indispensable Role in Healthcare.............. II-1 Market Overview.............. II-2 Focus on Noteworthy Trends, Drivers and Issues II-3 Health Spending Outstrips Global Economic Growth, Spurring Opportunities for Medical Adhesives and Sealants II-3 Table 1: While All Other Industries Walk the Economic Tight Rope, the Healthcare Industry Remains an Exception With Spending Gains Outstripping Anemic World GDP Growth and Spurring Opportunities for Medical Adhesives and Sealants: World Healthcare Spending and Growth (In US$ Trillion) and % Real GDP Growth for the Years 2012 Through 2016 (includes corresponding Graph/Chart)..............II-4 Demographic Shifts and Societal Changes: The Foundation for Growth in the Healthcare Sector and Its Allied Markets II-4 Table 2: Aging Population Creates Strong Demand for Pharmaceuticals, Medical Devices, Services, Consumables and Supplies, Benefiting Healthcare Value Chain Players: Global Aging Population (in Thousands) by Age Group for the Years 1975, 2000, 2025, and 2050 (includes corresponding Graph/Chart).............. II-5 Growing Number of Surgeries: The Foundation for Growth of Surgical Adhesives and Sealants..............II-6 Conventional Intracutaneous Sutures and Staples Lose Relevance Amid Surgical Procedure Innovation II-7 Growing Prominence of Adhesive Dentistry Drives Growth of Dental Adhesives and Sealants..............II-8 Table 3: Evolving Dental Care System and Favorable Economics of Dental Practice As Measured by Density of Dentists Sets the Right Business Climate for Dental Adhesives and Sealants: Number of Dentists Per Million People by Country for the Year 2015 (includes corresponding Graph/Chart) II-9 Shift to Value-Based Healthcare Pushes the Medical Device Industry Into a Period Transition, Spurring Opportunities for High Value Adhesives and Sealants II-9 Pressure Sensitive Adhesives Gain Significance in Medical Applications.............. II-10 Focus on Infection Control Drives Interest in Sterilization Resistant Adhesives..............II-11 Growing Focus On Regenerative Medicine Spurs Opportunities for Next Generation Tissue Adhesives, Sealants and Hemostatic Agents.............. II-12 Competition: A Review..............II-13 Trends Across Product Markets II-14 Synthetic Adhesives and Sealants: The Largest Product Market II-14 Huge Unmet Needs Open a Hidden Goldmine for Biodegradable, Biocompatible and Elastic Sealants II-14 A Peek Into Challenges Faced by Fibrin Sealants II-15 Cyanoacrylate: The Medical “Superglue” With Potential for Growth.............. II-16 Overview of 2-Octyl Cyanoacrylate Adhesives Market II-16 Dural Sealants Market to Maintain Momentum over the Short-Term II-17 Trend Towards Simplicity Throws the Spotlight on Single Component Adhesives and Multifunctional Adhesive Systems II-18 Elastic Surgical Adhesives Critical for Lung and Cardiovascular Surgeries..............II-19 Regulatory Concerns for Medical Adhesives and Sealants II-20

2. ADHESIVES and SEALANTS - A CURTAIN RAISER II-21 Adhesives.............. II-21 Sealants.............. II-21 Medical Adhesives and Sealants II-21 Medical Adhesives vis-a-vis Industrial Grade Adhesives II-21 Evolution of Adhesives..............II-22 Pressure Sensitive Adhesives Bag Higher Attention II-23 Tissue Sealants Make Surgeries Trouble-Free II-23 Banking on Ongoing Innovations..............II-24

3. SEGMENTAL OVERVIEW.............. II-25 Chemical Nature of Adhesives and Sealants II-25 Surgical Sealant Material and Applications II-25 Synthetic Adhesives and Sealants II-25 Acrylics.............. II-26 Anaerobic Adhesives..............II-26 Cyanoacrylate.............. II-26 Cyanoacrylate Tissue Sealants II-27 Silicones.............. II-28 Types of Silicone Adhesives II-28 Advantages Offered by Silicone Pressure Sensitive Adhesives II-28 Characteristic Traits of Silicones II-28 Other Synthetic Polymers..............II-29 Polyurethane Adhesives..............II-29 Benefits of Polyurethane..............II-29 Drawbacks of Polyurethane..............II-29 Epoxies.............. II-29 Benefits of Epoxies..............II-30 Polymeric Adhesives..............II-30 Thermosets.............. II-30 Thermoplastics..............II-30 Polyethylene Glycol Adhesives II-30 Polyester Adhesives..............II-30 Natural-Polymer based Adhesives and Sealants II-31 Albumin-based Sealants..............II-31 Bovine Serum Albumin..............II-31 Collagen-based Sealants..............II-31 Fibrin Sealants.............. II-32 Human Recombinant Fibrin Sealant II-32 Fibrin Sealant Application in Various Surgeries II-32 Cardiac Surgery.............. II-32 Plastic Surgery.............. II-33 Thoracic Surgery..............II-33 Vascular Surgery..............II-33 Plasma and Protein based Sealants II-33 Other Natural Polymer-based Sealants II-33 Application Specific Categorization II-33 Dental Applications..............II-33 Adhesives and Sealants for Dentistry II-34 A Backdrop.............. II-34 Emerging Adhesive and Sealant Application Trends in Dentistry II-34 Harmful Cavities - A Sealant Seizure II-34 Esthetic Dental Care..............II-35 Dental Sealants and Composites - A Key Note II-35 Composite Resins.............. II-35 Segmental Overview of Dental Adhesives and Sealants II-36 Denture and Orthodontic Bonding Agents II-36 Pit and Fissure Sealants and Luting Cements II-36 Pit and Fissure Sealants..............II-36 Luting Cements.............. II-37 Restorative Adhesives and Sealants II-37 Super Poligrip Adhesive Cream II-38 Secure Denture Adhesive..............II-38 Sea-Bond Denture Adhesive Strips II-38 Fixodent Denture Adhesive Cream II-39 Fitty Dent Adhesive..............II-39 Cushion Grip Adhesive..............II-39 Dental Fluorosis - A Key Application Area II-39 Glass Ionomers - Raging Hot in Restorative Dentistry II-39 Tray Adhesives..............II-40 Dental Surgical Tissue Bonding Agents for Dental Reconstruction.............. II-40 Medical Applications..............II-40 Medical Adhesives and Sealants for Surgical and External Applications.............. II-40 Adhesives and Sealants for Surgical/Internal Medical Applications.............. II-40 Vital Factors to be Considered While Using Surgical Adhesives II-41 Significance of Surgical Adhesives and Sealants II-41 Surgical Adhesive and Sealants Utility in Surgeries II-42 Why Use Medical Adhesives and Sealants Over Traditional Sutures and Staples?..............II-42 Surgical Sealants as an Adjunct to Sutures and Staples II-42 A ‘Functional' Invasion..............II-43 A Focus on Surgical Adhesives and Sealants' Applications in Surgical Procedures..............II-44 Surgical Sealants for PTCA Punctures II-44 Adhesives and Sealants for External Medical Applications II-44 Adhesives for Wound Management: Impressed by Value II-44 Other Categorizations of Medical Adhesives and Sealants II-45 By Curing Methodology..............II-45 Light-Curable Adhesives..............II-45 Radiation-Cured Adhesives..............II-45 By Functional Type.............. II-45 By Physical Form.............. II-45

4. TECHNOLOGICAL INNOVATIONS..............II-46 Nanoparticle Glues for Sealing Surgical Openings II-46 TissueGlu - A Breakthrough for Sealing Internal Incisions II-46 Bio-Adhesives Gain Notable Interest from Researcher Community II-47 Advanced Adhesive Formulations from Medical Device Manufacturers II-47 Loctite 4902 and Loctite 4903 by Henkel II-48 215-CTH-UR-SC by Dymax..............II-48 TissuGlu Surgical Adhesive Presents Effective Solution against Seromas.............. II-48 Adhesive Films with High Porosity Developed for Promotion of Angiogenesis.............. II-49 Bluestar Silicones Unveils New Products under Silbione® Silicone Adhesives Line..............II-50 Dymax Develops 1405-M-UR-SC Medical Device Adhesive II-51 Scapa Healthcare Introduces MEDIFIX Solutions™ for Wearable Mobile Device Applications..............II-51 Researchers Develop Fully-Synthetic Surgical Adhesive for Wet Tissue.............. II-51 Adhesives for use in Balloon Catheter Assemblies II-52 Vancive Medical Technologies™ Launches BeneHold Medical Tape Strips.............. II-53 Fabrico Introduces Custom-Formulated Medical- Grade Adhesives II-53 MAR to Develop Polyurethane-Based Medical Adhesive Products II-54 Researchers at Boston Children's Hospital Develop HLAA Cardiac Glue.............. II-54 EuroMed Develops HydroSoft Soft Adhesives for Long Duration Wearable Device Fixation..............II-55 Adhesive Research Develops SoftWear Adhesives for Affixing Large Wearable Medical Devices..............II-55 Researchers Develop Aldehyde Dextran and Epsilon-PL with Low Cytotoxicity.............. II-56 Researchers Discover Novel Bacterial Glue with Potential Medical Applications..............II-56 Faster Time to Market Needs Shirk the Innovation Lull II-56 Visible and Ultraviolet Light Cured Products II-57 Under Trials.............. II-57 Surgical Sealants to Prevent Fluid and Air Leaches II-57 Transparent Hydrogel for Eye Surgeries II-57

5. PRODUCT INTRODUCTIONS/INNOVATIONS II-58 Connexicon Medical Unveils INDERMIL® flexifuze™ II-58 Wacker Rolls Out Silpuran 2117 Silicone Adhesive II-58 Bluestar Silicones Introduces Silbione HC2 2022 Silicone Skin Adhesive.............. II-58 Dymax to Showcase LED-Optimized Catheter Adhesive II-58 FLEXcon Unveils dermaFLEX™ Adhesives II-58 Sealantis to Launch Seal-V in Europe II-58 Iranian Researchers Develop Dental Adhesives II-58

6. REGULATORY APPROVALS.............. II-59 Cohera Medical Bags FDA Approval for TissuGlu II-59 Ethicon Receives FDA Approval for Evarrest Fibrin Sealant Patch in Adult Liver Surgery..............II-59 Vectura Group Secures FDA Approval for RAPLIXAâ„¢ II-59 Cohera Medical Gains Expedited Access Pathway Designation for Sylys Surgical Sealant..............II-59 Cohera Medical Receives FDA Approval for TissuGlu II-59 Cohera Medical Bags CE Marking Approval for Sylys Surgical Sealant.............. II-59 HemCon Medical Technologies Receives Regulatory Approval to Sell Products in China..............II-59 Ocular Therapeutix Secures FDA Approval for ReSure Sealant II-60 Tenaxis Medical Bags Expanded CE Mark Approval for ArterX Surgical Sealant.............. II-60

7. RECENT INDUSTRY ACTIVITY..............II-61 DENTSPLY International Merges with Sirona Dental Systems II-61 Cohera Medical Inks Agreement with B. Braun Surgical II-61 LaunchPad Medical Inks Agreement with Stryker II-61 Gecko Biomedical Secures Funding from Bpifrance II-61 Cohera Medical Receives $50 Million Funding II-61 LifeBond Bags US$27 Million Funding II-61 Integra LifeSciences Acquires DuraSeal Product Series II-62 Covidien Takes Over Sapheon..............II-62 Cardinal Health Snaps Up AccessClosure II-62 The Medicines Company to Acquire Tenaxis II-62 HemCon Medical Technologies Enters into Hemostasis and Compression Products Agreement with Premier II-62 HemCon Medical Technologies Joins aptitude II-62 Teijin Pharma Collaborates with Chemo-Sero- Therapeutic Research Institute.............. II-62 LifeBond to Raise $25 Million for Development of LifeSeal Product II-63 Cohera Medical Secures Additional $9.3 Million Funding II-63 Covidien to Sell Confluent Surgical Product Line to Integra LifeSciences.............. II-63 Vancive Medical Technologies and CareFusion Inks Exclusive Agreement.............. II-63 Amerinet Choice Enters into a New Agreement with Medical Solutions International..............II-63 Tissuemed Inks Distribution Agreement with MEA Medical Solutions II-63 Chemence Medical Products Terminates Octylseal Supply Agreement II-63

8. FOCUS ON SELECT KEY PLAYERS..............II-64 3M Company (USA).............. II-64 Adhesives Research, Inc. (USA) II-64 Advanced Medical Solutions Group plc (UK) II-65 B. Braun Melsungen AG (Germany)..............II-65 Baxter International, Inc. (USA) II-65 C. R. Bard, Inc. (USA)..............II-66 Cohera Medical, Inc. (USA)..............II-66 CryoLife, Inc. (USA)..............II-67 Dentsply Sirona Inc. (USA)..............II-67 HemCon Medical Technologies, Inc. (USA) II-67 Integra Life Sciences Corporation (USA) II-68 Johnson and Johnson (USA)..............II-68 Ethicon, Inc. (USA)..............II-68 Kerr Corporation (USA)..............II-69 Medtronic Plc (USA).............. II-69 Procter and Gamble Company (USA) II-70 Sealantis Ltd. (Israel)..............II-70 Vivostat A/S (Denmark)..............II-70

9. GLOBAL MARKET PERSPECTIVE..............II-71 Table 4: World Recent Past, Current and Future Analysis for Medical Adhesives and Sealants by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart) II-71

Table 5: World Historic Review for Medical Adhesives and Sealants by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart)..............II-72

Table 6: World 14-Year Perspective for Medical Adhesives and Sealants by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets for Years 2009, 2016 and 2022 (includes corresponding Graph/Chart) II-73 By Product Group/Segment..............II-74 Table 7: World Recent Past, Current and Future Analysis for Synthetic Adhesives and Sealants by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart) II-74

Table 8: World Historic Review for Synthetic Adhesives and Sealants by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart)..............II-75

Table 9: World 14-Year Perspective for Synthetic Adhesives and Sealants by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets for Years 2009, 2016 and 2022 (includes corresponding Graph/Chart) II-76

Table 10: World Recent Past, Current and Future Analysis for Synthetic Adhesives and Sealants by Product Segment - Acrylic, Cyanoacrylate, Silicone and Other Synthetic Adhesives and Sealants Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart)..............II-77

Table 11: World Historic Review for Synthetic Adhesives and Sealants by Product Segment - Acrylic, Cyanoacrylate, Silicone and Other Synthetic Adhesives and Sealants Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart) II-78

Table 12: World 14-Year Perspective for Synthetic Adhesives and Sealants by Product Segment - Percentage Breakdown of Dollar Sales for Acrylic, Cyanoacrylate, Silicone and Other Synthetic Adhesives and Sealants Markets for Years 2009, 2016 and 2022 (includes corresponding Graph/Chart) II-79

Table 13: World Recent Past, Current and Future Analysis for Acrylic Adhesives and Sealants by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart) II-80

Table 14: World Historic Review for Acrylic Adhesives and Sealants by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart)..............II-81

Table 15: World 14-Year Perspective for Acrylic Adhesives and Sealants by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets for Years 2009, 2016 and 2022 (includes corresponding Graph/Chart) II-82

Table 16: World Recent Past, Current and Future Analysis for Cyanoacrylate Adhesives and Sealants by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart) II-83

Table 17: World Historic Review for Cyanoacrylate Adhesives and Sealants by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart)..............II-84

Table 18: World 14-Year Perspective for Cyanoacrylate Adhesives and Sealants by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets for Years 2009, 2016 and 2022 (includes corresponding Graph/Chart)..............II-85

Table 19: World Recent Past, Current and Future Analysis for Silicone Adhesives and Sealants by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart) II-86

Table 20: World Historic Review for Silicone Adhesives and Sealants by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart)..............II-87

Table 21: World 14-Year Perspective for Silicone Adhesives and Sealants by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets for Years 2009, 2016 and 2022 (includes corresponding Graph/Chart) II-88

Table 22: World Recent Past, Current and Future Analysis for Other Synthetic Adhesives and Sealants by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart) II-89

Table 23: World Historic Review for Other Synthetic Adhesives and Sealants by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart)..............II-90

Table 24: World 14-Year Perspective for Other Synthetic Adhesives and Sealants by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets for Years 2009, 2016 and 2022 (includes corresponding Graph/Chart)..............II-91

Table 25: World Recent Past, Current and Future Analysis for Natural Adhesives and Sealants by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart) II-92

Table 26: World Historic Review for Natural Adhesives and Sealants by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart)..............II-93

Table 27: World 14-Year Perspective for Natural Adhesives and Sealants by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets for Years 2009, 2016 and 2022 (includes corresponding Graph/Chart) II-94

Table 28: World Recent Past, Current and Future Analysis for Natural Adhesives and Sealants by Product Segment - Albumin, Collagen, Fibrin and Other Natural Adhesives and Sealants Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart)..............II-95

Table 29: World Historic Review for Natural Adhesives and Sealants by Product Segment - Albumin, Collagen, Fibrin and Other Natural Adhesives and Sealants Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart) II-96

Table 30: World 14-Year Perspective for Natural Adhesives and Sealants by Product Segment - Percentage Breakdown of Dollar Sales for Albumin, Collagen, Fibrin and Other Natural Adhesives and Sealants Markets for Years 2009, 2016 and 2022 (includes corresponding Graph/Chart) II-97

Table 31: World Recent Past, Current and Future Analysis for Albumin Adhesives and Sealants by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart) II-98

Table 32: World Historic Review for Albumin Adhesives and Sealants by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart)..............II-99

Table 33: World 14-Year Perspective for Albumin Adhesives and Sealants by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets for Years 2009, 2016 and 2022 (includes corresponding Graph/Chart) II-100

Table 34: World Recent Past, Current and Future Analysis for Collagen Adhesives and Sealants by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart) II-101

Table 35: World Historic Review for Collagen Adhesives and Sealants by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart)..............II-102

Table 36: World 14-Year Perspective for Collagen Adhesives and Sealants by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets for Years 2009, 2016 and 2022 (includes corresponding Graph/Chart) II-103

Table 37: World Recent Past, Current and Future Analysis for Fibrin Adhesives and Sealants by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart) II-104

Table 38: World Historic Review for Fibrin Adhesives and Sealants by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart)..............II-105

Table 39: World 14-Year Perspective for Fibrin Adhesives and Sealants by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets for Years 2009, 2016 and 2022 (includes corresponding Graph/Chart) II-106

Table 40: World Recent Past, Current and Future Analysis for Other Natural Adhesives and Sealants by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart) II-107

Table 41: World Historic Review for Other Natural Adhesives and Sealants by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart)..............II-108

Table 42: World 14-Year Perspective for Other Natural Adhesives and Sealants by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets for Years 2009, 2016 and 2022 (includes corresponding Graph/Chart)..............II-109 By Application.............. II-110 Table 43: World Recent Past, Current and Future Analysis for Medical Adhesives and Sealants in Dental Applications by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart).............. II-110

Table 44: World Historic Review for Medical Adhesives and Sealants in Dental Applications by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart) II-111

Table 45: World 14-Year Perspective for Medical Adhesives and Sealants in Dental Applications by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets for Years 2009, 2016 and 2022 (includes corresponding Graph/Chart)..............II-112

Table 46: World Recent Past, Current and Future Analysis for Adhesives and Sealants in Medical Applications by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart) II-113

Table 47: World Historic Review for Adhesives and Sealants in Medical Applications by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart)..............II-114

Table 48: World 14-Year Perspective for Adhesives and Sealants in Medical Applications by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets for Years 2009, 2016 and 2022 (includes corresponding Graph/Chart)..............II-115

III. MARKET

1. THE UNITED STATES.............. III-1 A.Market Analysis.............. III-1 Outlook.............. III-1 Advanced Formulations and Efforts by Medical Device Vendors to Support Medical Adhesives and Sealants Market III-1 Product Innovation - A Key Factor to Thrive in Medical Adhesives and Sealants Market III-2 Fibrin-based Patches Gaining Ground III-3 Fissure Sealants for Dental Applications III-3 Cosmetic Surgeries - Going ‘Invasive' on Conventional Sealants III-4 US First-Aid Category Sounds Strong with Ample Choices III-4 Tissue Adhesives and Sealants Harness Growth in the US Market III-4 Tissue Sealants Bank Upon Growing Number of Approved Indications.............. III-4 Competitive Landscape..............III-5 Aging Population Drives Demand III-5 State Agencies Focus on School Sealant Programs to Reduce Healthcare Cost..............III-5 Product Launches/Introduction..............III-6 FDA Approvals.............. III-6 Strategic Corporate Developments III-7 Select Players.............. III-9 B.Market Analytics..............III-16 Table 49: US Recent Past, Current and Future Analysis for Medical Adhesives and Sealants by Product Group/Segment - Synthetic Adhesives and Sealants (Acrylic, Cyanoacrylate, Silicone, and Others), and Natural Adhesives and Sealants (Albumin, Collagen, Fibrin, and Others) Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart).............. III-16

Table 50: US Historic Review for Medical Adhesives and Sealants by Product Group/ Segment - Synthetic Adhesives and Sealants (Acrylic, Cyanoacrylate, Silicone, and Others), and Natural Adhesives and Sealants (Albumin, Collagen, Fibrin, and Others) Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart) III-17

Table 51: US 14-Year Perspective for Medical Adhesives and Sealants by Product Group/ Segment - Percentage Breakdown of Dollar Sales for Synthetic Adhesives and Sealants (Acrylic, Cyanoacrylate, Silicone, and Others), and Natural Adhesives and Sealants (Albumin, Collagen, Fibrin, and Others) Markets for Years 2009, 2016 and 2022 (includes corresponding Graph/Chart).............. III-18

Table 52: US Recent Past, Current and Future Analysis for Medical Adhesives and Sealants by Application - Dental and Medical Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart) III-19

Table 53: US Historic Review for Medical Adhesives and Sealants by Application - Dental and Medical Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart).............. III-20

Table 54: US 14-Year Perspective for Medical Adhesives and Sealants by Application - Percentage Breakdown of Dollar Sales for Dental and medical Markets for Years 2009, 2016 and 2022 (includes corresponding Graph/Chart) III-21

2. CANADA.............. III-22 Market Analysis.............. III-22 Table 55: Canadian Recent Past, Current and Future Analysis for Medical Adhesives and Sealants by Product Group/Segment - Synthetic Adhesives and Sealants (Acrylic, Cyanoacrylate, Silicone, and Others), and Natural Adhesives and Sealants (Albumin, Collagen, Fibrin, and Others) Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart).............. III-23

Table 56: Canadian Historic Review for Medical Adhesives and Sealants by Product Group/Segment - Synthetic Adhesives and Sealants (Acrylic, Cyanoacrylate, Silicone, and Others), and Natural Adhesives and Sealants (Albumin, Collagen, Fibrin, and Others) Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart) III-24

Table 57: Canadian 14-Year Perspective for Medical Adhesives and Sealants by Product Group/Segment - Percentage Breakdown of Dollar Sales for Synthetic Adhesives and Sealants (Acrylic, Cyanoacrylate, Silicone, and Others), and Natural Adhesives and Sealants (Albumin, Collagen, Fibrin, and Others) Markets for Years 2009, 2016 and 2022 (includes corresponding Graph/Chart).............. III-25

Table 58: Canadian Recent Past, Current and Future Analysis for Medical Adhesives and Sealants by Application - Dental and Medical Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart) III-26

Table 59: Canadian Historic Review for Medical Adhesives and Sealants by Application - Dental and Medical Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart).............. III-27

Table 60: Canadian 14-Year Perspective for Medical Adhesives and Sealants by Application - Percentage Breakdown of Dollar Sales for Dental and medical Markets for Years 2009, 2016 and 2022 (includes corresponding Graph/Chart) III-28

3. JAPAN.............. III-29 A.Market Analysis.............. III-29 Strategic Corporate Development III-29 B.Market Analytics..............III-30 Table 61: Japanese Recent Past, Current and Future Analysis for Medical Adhesives and Sealants by Product Group/Segment - Synthetic Adhesives and Sealants (Acrylic, Cyanoacrylate, Silicone, and Others), and Natural Adhesives and Sealants (Albumin, Collagen, Fibrin, and Others) Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart).............. III-30

Table 62: Japanese Historic Review for Medical Adhesives and Sealants by Product Group/ Segment - Synthetic Adhesives and Sealants (Acrylic, Cyanoacrylate, Silicone, and Others), and Natural Adhesives and Sealants (Albumin, Collagen, Fibrin, and Others) Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart) III-31

Table 63: Japanese 14-Year Perspective for Medical Adhesives and Sealants by Product Group/Segment - Percentage Breakdown of Dollar Sales for Synthetic Adhesives and Sealants (Acrylic, Cyanoacrylate, Silicone, and Others), and Natural Adhesives and Sealants (Albumin, Collagen, Fibrin, and Others) Markets for Years 2009, 2016 and 2022 (includes corresponding Graph/Chart).............. III-32

Table 64: Japanese Recent Past, Current and Future Analysis for Medical Adhesives and Sealants by Application - Dental and Medical Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart) III-33

Table 65: Japanese Historic Review for Medical Adhesives and Sealants by Application - Dental and Medical Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart).............. III-34

Table 66: Japanese 14-Year Perspective for Medical Adhesives and Sealants by Application - Percentage Breakdown of Dollar Sales for Dental and medical Markets for Years 2009, 2016 and 2022 (includes corresponding Graph/Chart) III-35

4. EUROPE.............. III-36 A.Market Analysis.............. III-36 Product Launches/Introductions III-36 Strategic Corporate Developments III-37 Select Players.............. III-37 B.Market Analytics..............III-39 Table 67: European Recent Past, Current and Future Analysis for Medical Adhesives and Sealants by Geographic Region - France, Germany, Italy, UK, Spain, Russia and Rest of Europe Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart)..............III-39

Table 68: European Historic Review for Medical Adhesives and Sealants by Geographic Region - France, Germany, Italy, UK, Spain, Russia and Rest of Europe Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart) III-40

Table 69: European 14-Year Perspective for Medical Adhesives and Sealants by Geographic Region - Percentage Breakdown of Dollar Sales for France, Germany, Italy, UK, Spain, Russia and Rest of Europe Markets for Years 2009, 2016 and 2022 (includes corresponding Graph/Chart) III-41

Table 70: European Recent Past, Current and Future Analysis for Medical Adhesives and Sealants by Product Group/Segment - Synthetic Adhesives and Sealants (Acrylic, Cyanoacrylate, Silicone, and Others), and Natural Adhesives and Sealants (Albumin, Collagen, Fibrin, and Others) Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart).............. III-42

Table 71: European Historic Review for Medical Adhesives and Sealants by Product Group/ Segment - Synthetic Adhesives and Sealants (Acrylic, Cyanoacrylate, Silicone, and Others), and Natural Adhesives and Sealants (Albumin, Collagen, Fibrin, and Others) Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart) III-43

Table 72: European 14-Year Perspective for Medical Adhesives and Sealants by Product Group/Segment - Percentage Breakdown of Dollar Sales for Synthetic Adhesives and Sealants (Acrylic, Cyanoacrylate, Silicone, and Others), and Natural Adhesives and Sealants (Albumin, Collagen, Fibrin, and Others) Markets for Years 2009, 2016 and 2022 (includes corresponding Graph/Chart).............. III-44

Table 73: European Recent Past, Current and Future Analysis for Medical Adhesives and Sealants by Application - Dental and Medical Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart) III-45

Table 74: European Historic Review for Medical Adhesives and Sealants by Application - Dental and Medical Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart).............. III-46

Table 75: European 14-Year Perspective for Medical Adhesives and Sealants by Application - Percentage Breakdown of Dollar Sales for Dental and medical Markets for Years 2009, 2016 and 2022 (includes corresponding Graph/Chart) III-47

5. ASIA-PACIFIC.............. III-48 A.Market Analysis.............. III-48 Strategic Corporate Development III-48 B.Market Analytics..............III-49 Table 76: Asia-Pacific Recent Past, Current and Future Analysis for Medical Adhesives and Sealants by Geographic Region - China, India and Rest of Asia-Pacific Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart).............. III-49

Table 77: Asia-Pacific Historic Review for Medical Adhesives and Sealants by Geographic Region - China, India and Rest of Asia-Pacific Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart) III-50

Table 78: Asia-Pacific 14-Year Perspective for Medical Adhesives and Sealants by Geographic Region - Percentage Breakdown of Dollar Sales for China, India and Rest of Asia-Pacific Markets for Years 2009, 2016 and 2022 (includes corresponding Graph/Chart)..............III-51

Table 79: Asia-Pacific Recent Past, Current and Future Analysis for Medical Adhesives and Sealants by Product Group/Segment - Synthetic Adhesives and Sealants (Acrylic, Cyanoacrylate, Silicone, and Others), and Natural Adhesives and Sealants (Albumin, Collagen, Fibrin, and Others) Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart).............. III-52

Table 80: Asia-Pacific Historic Review for Medical Adhesives and Sealants by Product Group/Segment - Synthetic Adhesives and Sealants (Acrylic, Cyanoacrylate, Silicone, and Others), and Natural Adhesives and Sealants (Albumin, Collagen, Fibrin, and Others) Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart) III-53

Table 81: Asia-Pacific 14-Year Perspective for Medical Adhesives and Sealants by Product Group/Segment - Percentage Breakdown of Dollar Sales for Synthetic Adhesives and Sealants (Acrylic, Cyanoacrylate, Silicone, and Others), and Natural Adhesives and Sealants (Albumin, Collagen, Fibrin, and Others) Markets for Years 2009, 2016 and 2022 (includes corresponding Graph/Chart)..............III-54

Table 82: Asia-Pacific Recent Past, Current and Future Analysis for Medical Adhesives and Sealants by Application - Dental and Medical Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart) III-55

Table 83: Asia-Pacific Historic Review for Medical Adhesives and Sealants by Application - Dental and Medical Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart).............. III-56

Table 84: Asia-Pacific 14-Year Perspective for Medical Adhesives and Sealants by Application - Percentage Breakdown of Dollar Sales for Dental and medical Markets for Years 2009, 2016 and 2022 (includes corresponding Graph/Chart) III-57

6. LATIN AMERICA.............. III-58 Market Analysis.............. III-58 Table 85: Latin American Recent Past, Current and Future Analysis for Medical Adhesives and Sealants by Geographic Region - Brazil and Rest of Latin America Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart).............. III-58

Table 86: Latin American Historic Review for Medical Adhesives and Sealants by Geographic Region - Brazil and Rest of Latin America Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart) III-59

Table 87: Latin American 14-Year Perspective for Medical Adhesives and Sealants by Geographic Region - Percentage Breakdown of Dollar Sales for Brazil and Rest of Latin America Markets for Years 2009, 2016 and 2022 (includes corresponding Graph/Chart)..............III-60

Table 88: Latin American Recent Past, Current and Future Analysis for Medical Adhesives and Sealants by Product Group/Segment - Synthetic Adhesives and Sealants (Acrylic, Cyanoacrylate, Silicone, and Others), and Natural Adhesives and Sealants (Albumin, Collagen, Fibrin, and Others) Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart).............. III-61

Table 89: Latin American Historic Review for Medical Adhesives and Sealants by Product Group/Segment - Synthetic Adhesives and Sealants (Acrylic, Cyanoacrylate, Silicone, and Others), and Natural Adhesives and Sealants (Albumin, Collagen, Fibrin, and Others) Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart) III-62

Table 90: Latin American 14-Year Perspective for Medical Adhesives and Sealants by Product Group/Segment - Percentage Breakdown of Dollar Sales for Synthetic Adhesives and Sealants (Acrylic, Cyanoacrylate, Silicone, and Others), and Natural Adhesives and Sealants (Albumin, Collagen, Fibrin, and Others) Markets for Years 2009, 2016 and 2022 (includes corresponding Graph/Chart)..............III-63

Table 91: Latin American Recent Past, Current and Future Analysis for Medical Adhesives and Sealants by Application - Dental and Medical Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart) III-64

Table 92: Latin American Historic Review for Medical Adhesives and Sealants by Application - Dental and Medical Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart)..............III-65

Table 93: Latin American 14-Year Perspective for Medical Adhesives and Sealants by Application - Percentage Breakdown of Dollar Sales for Dental and medical Markets for Years 2009, 2016 and 2022 (includes corresponding Graph/Chart) III-66

7. REST OF WORLD.............. III-67 A.Market Analysis.............. III-67 Product Development..............III-67 Strategic Corporate Developments III-67 Sealantis Ltd. - A Major Israeli Player III-68 B.Market Analytics..............III-69 Table 94: Rest of World Recent Past, Current and Future Analysis for Medical Adhesives and Sealants by Product Group/Segment - Synthetic Adhesives and Sealants (Acrylic, Cyanoacrylate, Silicone, and Others), and Natural Adhesives and Sealants (Albumin, Collagen, Fibrin, and Others) Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart).............. III-69

Table 95: Rest of World Historic Review for Medical Adhesives and Sealants by Product Group/Segment - Synthetic Adhesives and Sealants (Acrylic, Cyanoacrylate, Silicone, and Others), and Natural Adhesives and Sealants (Albumin, Collagen, Fibrin, and Others) Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart) III-70

Table 96: Rest of World 14-Year Perspective for Medical Adhesives and Sealants by Product Group/Segment - Percentage Breakdown of Dollar Sales for Synthetic Adhesives and Sealants (Acrylic, Cyanoacrylate, Silicone, and Others), and Natural Adhesives and Sealants (Albumin, Collagen, Fibrin, and Others) Markets for Years 2009, 2016 and 2022 (includes corresponding Graph/Chart)..............III-71

Table 97: Rest of World Recent Past, Current and Future Analysis for Medical Adhesives and Sealants by Application - Dental and Medical Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart) III-72

Table 98: Rest of World Historic Review for Medical Adhesives and Sealants by Application - Dental and Medical Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart)..............III-73

Table 99: Rest of World 14-Year Perspective for Medical Adhesives and Sealants by Application - Percentage Breakdown of Dollar Sales for Dental and medical Markets for Years 2009, 2016 and 2022 (includes corresponding Graph/Chart) III-74

IV. COMPETITIVE LANDSCAPE

Total Companies Profiled: 63 (including Divisions/Subsidiaries - 69)

The United States (51) Canada (1) Japan (2) Europe (12) - France (1) - Germany (3) - The United Kingdom (3) - Rest of Europe (5) Asia-Pacific (Excluding Japan) (1) Middle East (2)

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