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  5. > Epithelial Cancer: Disease and Pipeline Analysis

Epithelial Cancer: Disease and Pipeline Analysis

  • January 2015
  • -
  • Industry Standard Research
  • -
  • 98 pages

Report Overview

This report offers a unique therapeutic assessment and in-depth market and pipeline analysis, providing a view of the epithelial ovarian cancer market not available elsewhere. This reports gives an overview of the current and future ovarian cancer clinical development market, the activities of the key market players, and
outlines trial and commercial regulatory environments.

What you will learn in this report:

- Global and country-specific incidence rates for ovarian cancer
- Active development pipeline, including promising new therapies currently in Early and Late-Stage Phases of development
- Analysis of clinical trial environments for new ovarian cancer therapies
- Areas of unmet need

How you can use this report:

- Identify and enhance commercial and development opportunities with an in-depth and current analysis of the global ovarian cancer market
- Understand how products currently in development could impact this market
- Assess the competition with an analysis and summary of companies active in this space

Table Of Contents

Epithelial Cancer: Disease and Pipeline Analysis
Table of Contents

Copyright and Usage Guidelines 6
Chapter 1 - Ovarian Cancer Disease Overview 9
Ovarian Cancer 10
Pathogenesis of Ovarian Cancer 11
Pathophysiology of Ovarian Cancer 12
Ovarian Cancer Risk Factors 13
Age 13
Reproductive History …13
Family History …13
Other factors …14
Infographic 15
Chapter 2 - Ovarian Cancer Epidemiology 16
Ovarian Cancer Incidence …17
Ovarian Cancer Mortality …22
Chapter 3 - Ovarian Cancer Diagnosis and Staging 24
Signs and Symptoms 25
Screening …25
Diagnosis …25
Serum CA 125 …25
Imaging 26
Malignancy Indices 27
Biopsy 27
Chapter 4 - Ovarian Cancer Staging 28
Chapter 5 - Treatment of Ovarian Cancer 32
Surgery for Ovarian Cancer …33
Chemotherapy …33
Paclitaxel 33
Carboplatin 34
Cisplatin 34
Docetaxel … 34
Pegylated Liposomal Doxorubicin (PLD) 34
Gemcitabine (Gemzar) …35
Topotecan …35
Pemetrexed 36
Yondelis (trabectedin) … 36
Targeted Therapy …38
Bevacizumab (Avastin) …38
Treatment by Disease Stage and Type …40
Early Stage Ovarian Cancer 40
Late Stage Ovarian Cancer …40
Recurrent Ovarian Cancer …44
Chapter 6 Ovarian Cancer Prognosis 46
Chapter 7 Environmental Analysis 49
Areas of Unmet Need …50
Patient and Physician Awareness 50
Effective Screening and Early Diagnosis …50
Implementation of Clinical Best Practice 50
Clinical Trial Design Issues …51
Prevention of Tumour Recurrence …52
Targeted Approaches to Treatment …53
Major Market Analysis 54
Trial and Recruitment Environment 54
Regulatory Environment 55
Competitive Product Landscape 56
Pricing and Reimbursement Environment …57
Emerging Market Analysis …59
Trial and Recruitment Environment 59
Regulatory Environment 61
Competitive Product Landscape 62
Pricing and Reimbursement Environment …62
Patient Recruitment Environment 64
Drug Development Field …65
Chapter 8 Drug Development in Ovarian Cancer 66
Angiogenesis Inhibitors …70
Pazopanib (Votrient), GlaxoSmithKline …71
Cediranib, AstraZeneca 72
Nintedanib (Vargatef), Boehringer Ingelheim …74
Trebananib, Amgen 75
PARP (poly ADP ribose polymerase) inhibitors …76
Olaparib, AstraZeneca …79
Niraparib (MK-4827), Tesaro 80
Rucaparib, Clovis Oncology …81
Folate Receptor Overexpression 82
Vintafolide (Vynfinit), Merck and Endocyte …83
Farletuzumab, Eisai (Morphotek) 84
Immunotherapy 85
CVac, PrimaBiomed 86
Intracellular Signalling Cascades 88
Binimetinib (MEK162), Array Pharma/Novartis …88
Cytotoxics 91
Karenitecin, BioNumerik 92
Trabectedin (Yondelis), Janssen (JandJ) …93
Opaxio (paclitaxel poliglumex), Cell Therapeutics 93
Paclical (encapsulated paclitaxel), Oasmia Pharmaceutical …94
Other Mechanisms 95
Citations 96
Ovarian Cancer Diagnosis and Treatment Guidelines 97
About Industry Standard Research 98

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