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Viscosupplementation - 5EU Analysis and Market Forecasts

Summary

Osteoarthritis (OA) constitutes a growing public health burden, and is the most common cause of musculoskeletal disability across the globe. Intra-articular viscosupplementation with hyaluronic acid (HA) has become an increasingly accepted therapeutic alternative to knee replacement surgery in the symptomatic management of OA over the past decade. Going forward, palliative pain treatments are likely to continue to fare well as healthcare reform kicks in and lag times for knee replacement become the norm.

The increasing prevalence of OA and the lower cost of prescribing viscosupplementation compared with knee replacement surgery have prompted the medical community to take a closer look at this therapy. However, there is a growing concern among physicians that the updated American Academy of Orthopaedic Surgeons (AAOS) and Osteoarthritis Research Society International (OARSI) treatment guidelines for knee OA will result in increased insurance denials for viscosupplementation. Moving forward, industry consolidation and intense competition in the viscosupplementation arena will cause increasing numbers of companies to augment their research efforts to differentiate their products from the lower-end competitors. The motivation to incorporate the favorable properties of different agents into a more effective viscosupplementation product has led to the manipulation and development of next-generation HA formulations consisting of not only HAs, but also pharmaceuticals, such as corticosteroids.

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Highlights

Key Questions Answered

- Future growth in the viscosupplementation market lies in the one-injection segment. What are the current adoption trends in different geographies? How will one-injection segment drive the market revenue growth in the upcoming years?
- Reimbursement is the single greatest barrier to the market growth for viscosupplementation procedures. How does the current payer mix look like in different countries?
- In recent years, there has been an expansion in the use of intra-articular HA viscosupplementation for treating OA at hips, shoulders, and other small joints. What are the current adoption trends in different regions?
- Because the most prevalent treatment regimen varies from region to region, the competitive landscape in the viscosupplementation space can be quite different across the geographies covered in this report. Who are the leading players in the viscosupplementation market in different countries?

Reasons to buy

- “What Do Physicians Think” quotes provide a unique insight into how healthcare professionals are reacting to events within the industry, and what their responses could mean for industry strategists. This information is essential for all strategic decision makers in every organization allowing them to act on high quality information.

Table Of Contents

Viscosupplementation - 5EU Analysis and Market Forecasts
1 Table of Contents
1.1 List of Tables
1.2 List of Figures
2 Introduction
2.1 Catalyst
2.2 Related Reports
3 Treatment Modalities Overview
3.1 Treatment Paradigm
3.1.1 Physical Therapies
3.1.2 Medications
3.1.3 Hyaluronic Acid Viscosupplementation
3.1.4 Surgical Intervention
4 Industry Overview
4.1 Procedural Trends
4.2 Market Access
4.3 Reimbursement
4.4 Mergers and Acquisitions/Key Partnerships
4.4.1 Meda AB Acquires Rottapharm|Medaus for $3.1 Billion (October 2014)
4.4.2 Founders of Anteis Establish Aptissen (March 2014)
4.4.3 Bioventus Acquires Durolane Assets from Galderma (February 2014)
4.4.4 Zimmer to Combine with Biomet in a Transaction Valued at $13.35 Billion (April 2014)
4.4.5 Johnson and Johnson Acquires Synthes for $19.7 Billion (June 2012)
5 Market Drivers, Opportunities, and Barriers
5.1 Driver: Rising Prevalence of OA
5.2 Driver: Multimodal Treatment Paradigm for OA
5.3 Driver: Viscosupplementation Delays Total Knee Replacement
5.4 Driver: Side Effects of NSAIDs, Corticosteroids, and Narcotics
5.5 Driver: Direct-To-Consumer Marketing
5.6 Opportunity: Expanding Indications
5.7 Opportunity: New-Generation HA Derivatives
5.8 Opportunity: Increased Use After Arthroscopic Surgeries
5.9 Opportunity: Self-Pay Market
5.10 Opportunity: Emerging Countries
5.11 Barrier: Unfavorable Reimbursement Scenario
5.12 Barrier: Pricing Erosion
5.13 Barrier: Cost-Effective Pharmacological Therapies
5.14 Barrier: Will The Rising Popularity of PRP Injection Impact the Viscosupplementation Market?
5.15 Barrier: Cost-Conscious Patients in Emerging Countries
6 Unmet Needs
6.1 Lack of Consensus on Clinical Efficacy of Viscosupplementation in Knee OA
6.2 Insufficient Evidence to Prove the Clinical Efficacy of Viscosupplementation in Other Joints
6.3 Better Understanding of the Basic Science
6.4 Ultrasound-Guided Injection
7 Competitive Assessment
7.1 Major Viscosupplementation Products
7.1.1 Adant
7.1.2 Arthrum
7.1.3 Curavisc
7.1.4 Durolane
7.1.5 Euflexxa
7.1.6 Fermathron
7.1.7 Gel-One
7.1.8 Go-On
7.1.9 Hyalgan
7.1.10 Hyalubrix and HyalOne
7.1.11 Jonexa
7.1.12 NeoVisc
7.1.13 Orthovisc and Monovisc
7.1.14 Ostenil
7.1.15 Recosyn
7.1.16 RenehaVis
7.1.17 Supartz/ARTZ
7.1.18 Suplasyn
7.1.19 Synocrom
7.1.20 Synolis V-A
7.1.21 Synovial
7.1.22 Synvisc and Synvisc-One
7.2 Other Viscosupplementation Products
8 Pipeline Products
8.1 Overview
8.2 Gel-Syn (IBSA Institut Biochimique S.A.)
8.3 Cingal (Anika Therapeutics)
8.4 Hydros-TA (Carbylan Therapeutics)
8.5 Additional Indication for Synvisc-One (Sanofi)
8.6 Hymovis (Fidia Farmaceutici S.p.A.)
8.7 HA-NSAID Conjugates (Seikagaku Corporation)
8.8 Additional Indication for Supartz/ARTZ (Seikagaku Corporation)
8.9 Clodronate-HA Conjugates (Abiogen Pharma)
9 Current and Future Players
9.1 Trends in Corporate Strategy
9.2 Major Manufacturers
9.2.1 Anika Therapeutics
9.2.2 Ferring Pharmaceuticals
9.2.3 Fidia Farmaceutici S.p.A.
9.2.4 Meda AB
9.2.5 Sanofi
9.2.6 Seikagaku Corporation
9.3 Major Marketing Partners
9.3.1 Bioventus
9.3.2 DePuy Synthes
9.3.3 Zimmer-Biomet
10 Market Outlook
10.1 Market Share Analysis by Country
10.2 By Market Segment
10.2.1 One-Injection Segment
10.2.2 Three-Injection Segment
10.2.3 Five-Injection Segment
10.3 By Geography
10.3.1 Overview
10.3.2 France
10.3.3 Germany
10.3.4 Italy
10.3.5 Spain
10.3.6 UK
11 Appendix
11.1 Bibliography
11.2 Abbreviations
11.3 Report Methodology
11.3.1 Overview
11.3.2 Coverage
11.3.3 Secondary Research
11.3.4 Forecasting Methodology
11.3.5 Primary Research — Key Opinion Leader Interviews
11.3.6 Expert Panel Validation
11.4 Physicians and Specialists Included in This Study
11.5 About the Authors
11.5.1 Analysts
11.5.2 Jim Coutcher, MS, Global Head of Healthcare
11.6 About MediPoint
11.7 About GlobalData
11.8 Contact Us
11.9 Disclaimer

1.1 List of Tables
Table 1: 5EU Procedure Trends for Viscosupplementation, by Joint Type, 2012-2021
Table 2: 5EU Procedure Trends for Viscosupplementation, by Treatment Regimen, 2012-2021
Table 3: Differences Between US FDA Approval and EU CE Marking of Medical Devices
Table 4: Potential Clinical Benefits of HA-NSAIDs Conjugates
Table 5: Current CPGs on the Use of Viscosupplementation in Joints Other Than the Knee
Table 6: Product Profile - Adant
Table 7: Product Profile - Arthrum
Table 8: Product Profile - Curavisc
Table 9: Product Profile - Durolane
Table 10: Product Profile - Euflexxa
Table 11: Product Profile - Fermathron
Table 12: Product Profile - Gel-One
Table 13: Product Profile - Go-On
Table 14: Product Profile - Hyalgan
Table 15: Product Profile - Hyalubrix and HyalOne
Table 16: Product Profile - Jonexa
Table 17: Product Profile - NeoVisc
Table 18: Product Profile - Orthovisc and Monovisc
Table 19: Product Profile - Ostenil
Table 20: Product Profile - Recosyn
Table 21: Product Profile - RenehaVis
Table 22: Product Profile - Supartz/ARTZ
Table 23: Product Profile - Suplasyn
Table 24: Product Profile - Synocrom
Table 25: Product Profile - Synolis V-A
Table 26: Product Profile - Synovial
Table 27: Product Profile - Synvisc and Synvisc-One
Table 28: Other Viscosupplementation Products in the 5EU Market, 2015
Table 29: Major Pipeline Products in the Viscosupplementation Market, 2015
Table 30: Company Profile - Anika Therapeutics
Table 31: Anika Therapeutics' Viscosupplementation Portfolio Assessment, 2015
Table 32: SWOT Analysis - Anika Therapeutics
Table 33: Company Profile - Ferring Pharmaceuticals
Table 34: Ferring Pharmaceutical's Viscosupplementation Portfolio Assessment, 2015
Table 35: SWOT Analysis - Ferring Pharmaceuticals
Table 36: Company Profile - Fidia Farmaceutici S.p.A.
Table 37: Fidia Farmaceutici S.p.A.'s Viscosupplementation Portfolio Assessment, 2015
Table 38: SWOT Analysis - Fidia Farmaceutici S.p.A.
Table 39: Company Profile - Meda AB
Table 40: Meda AB's Viscosupplementation Portfolio Assessment, 2015
Table 41: SWOT Analysis - Meda AB
Table 42: Company Profile - Sanofi
Table 43: Sanofi's Viscosupplementation Portfolio Assessment, 2015
Table 44: SWOT Analysis - Sanofi
Table 45: Company Profile - Seikagaku Corporation
Table 46: Seikagaku Corporation's Viscosupplementation Portfolio Assessment, 2015
Table 47: SWOT Analysis - Seikagaku Corporation
Table 48: Company Profile - Bioventus
Table 49: Bioventus' Viscosupplementation Portfolio Assessment, 2015
Table 50: SWOT Analysis - Bioventus
Table 51: Company Profile - DePuy Synthes
Table 52: DePuy Synthes' Viscosupplementation Portfolio Assessment, 2015
Table 53: SWOT Analysis - DePuy Synthes
Table 54: Company Profile - Zimmer-Biomet
Table 55: Zimmer-Biomet's Viscosupplementation Portfolio Assessment, 2015
Table 56: SWOT Analysis - Zimmer-Biomet
Table 57: 5EU Viscosupplementation One-Injection Market Revenue ($m), by Region, 2012-2021
Table 58: 5EU Viscosupplementation Three-Injection Market Revenue ($m), by Region, 2012-2021
Table 59: 5EU Viscosupplementation Five-Injection Market Revenue ($m), by Region, 2012-2021
Table 60: 5EU Viscosupplementation Market Revenue ($m), by Segment, 2011-2020
Table 61: 5EU Viscosupplementation Market Revenue ($m), by Geography, 2012-2021
Table 62: France Viscosupplementation Market Revenue ($m), 2012-2021
Table 63: Germany Viscosupplementation Market Revenue ($m), 2012-2021
Table 64: Italy Viscosupplementation Market Revenue ($m), 2012-2021
Table 65: Spain Viscosupplementation Market Revenue ($m), 2012-2021
Table 66: UK Viscosupplementation Market Revenue ($m), 2012-2021

1.2 List of Figures
Figure 1: 5EU Procedure Trends for Viscosupplementation, by Joint Type, 2014
Figure 2: 5EU Adoption Trends for Viscosupplementation, by Treatment Regimen, 2014
Figure 3: 5EU Procedure Trends for Viscosupplementation, by Treatment Regimen, 2012-2021
Figure 4: Payer Mix for Viscosupplementation in France, 2014
Figure 5: Payer Mix for Viscosupplementation in Germany, 2014
Figure 6: Payer Mix for Viscosupplementation in Italy, 2014
Figure 7: Payer Mix for Viscosupplementation in Spain, 2014
Figure 8: Payer Mix for Viscosupplementation in the UK, 2014
Figure 9: France Viscosupplementation Market Share, by Product, 2014
Figure 10: Germany Viscosupplementation Market Share, by Product, 2014
Figure 11: Italy Viscosupplementation Market Share, by Product, 2014
Figure 12: Spain Viscosupplementation Market Share, by Product, 2014
Figure 13: UK Viscosupplementation Market Share, by Product, 2014
Figure 14: 5EU Viscosupplementation One-Injection Market Revenue ($m), by Region, 2012-2021
Figure 15: 5EU Viscosupplementation Three-Injection Market Revenue ($m), by Region, 2012-2021
Figure 16: 5EU Viscosupplementation Five-Injection Market Revenue ($m), by Region, 2012-2021
Figure 17: 5EU Viscosupplementation Market Revenue ($m), by Segment, 2012-2021
Figure 18: 5EU Viscosupplementation Market Revenue ($m), by Segment, 2014 and 2021
Figure 19: 5EU Viscosupplementation Market Revenue ($m), by Geography, 2014 and 2021
Figure 20: France Viscosupplementation Market Revenue ($m), 2012-2021
Figure 21: France Viscosupplementation Market Revenue Distribution, 2014 and 2021
Figure 22: Germany Viscosupplementation Market Revenue ($m), 2012-2021
Figure 23: Germany Viscosupplementation Market Revenue Distribution, 2014 and 2021
Figure 24: Italy Viscosupplementation Market Revenue ($m), 2012-2021
Figure 25: Italy Viscosupplementation Market Revenue Distribution, 2014 and 2021
Figure 26: Spain Viscosupplementation Market Revenue ($m), 2012-2021
Figure 27: Spain Viscosupplementation Market Revenue Distribution, 2014 and 2021
Figure 28: UK Viscosupplementation Market Revenue ($m), 2012-2021
Figure 29: UK Viscosupplementation Market Revenue Distribution, 2014 and 2021
Figure 30: Breakdown of Physician Survey Participants by Geography (N=61)
Figure 31: Breakdown of Other Primary Research Participants by Geography (N=50)

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