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This BCC Research report provides a comprehensive discussion of single cell technologies, clinical applications, industry structure, important single cell analysis funding initiatives, global markets, patent status and companies. The market sizes are given for the years 2014, 2015 and 2020.

Use this report to:

Identify top research initiatives that are contributing to the growth of single-cell applications.
Analyze the global single-cell analysis market by end user, application, type, workflow step and geography. Learn about single-cell workflow steps and technologies.Receive a summary of the main industry acquisitions and strategic alliances from 2013 through 2015, including key alliance trends.

Highlights

The global single-cell analysis market was valued at $541.2 million in 2014. This market is projected to grow from $626.2 million in 2015 to $1.6 billion in 2020, a compound annual growth rate (CAGR) of 20.7% from 2015 to 2020.The global market for single-cell analysis products among research, drug development and applied end users is expected to increase from $386.1 million in 2015 to $808.5 million in 2020, a CAGR of 15.9% from 2015 to 2020.The global single-cell analysis diagnostics market segment is expected to increase from $240.1 million in 2015 to $796.8 million in 2020 with a CAGR of 27.1% from 2015 to 2020.

STUDY GOALS AND OBJECTIVES

The goal of BCC Research for this study is to provide an in-depth study of thesingle-cell analysis industry, an emerging industry with high market potential. Theglobal market is analyzed from five points of view: by end user, field of application,workflow step, technology and geography. The diagnostics market is examined byindication and test purpose. The market sizes are given for the years 2014, 2015 and2020.Market segments that provide exceptional growth opportunities include cancer andreproductive health.The report provides a comprehensive discussion of single-cell technologies, clinicalapplications, industry structure, important single-cell analysis funding initiatives, globalmarkets, patent status and companies. The report is designed to aid companies in theirstrategic planning efforts relating to life science tools and diagnostics.

REASONS FOR DOING THE STUDY

The life science industry is moving towards digitization with the advent of newertechnologies including advanced genetic sequencing and microfluidics systems. Asmany biological systems contain heterogeneous populations of cells, many analysismethods heretofore measured mixtures of different cell types.Single-cell analysis is a disruptive technology that enables analysis of single cells out ofa complex mixture of cells. This type of analysis is key to understanding complexsystems in fields as diverse as neurology, stem cell biology and cancer.

At the same time, advances in microfluidics technologies have enabled the analysis ofsmaller samples that are common with single cells.Based on this, single-cell analysis markets are rapidly emerging, and the need forindustry and market characterization is great.Also, the single-cell field is growing beyond basic research into applied fields andmolecular diagnostics applications.The outstanding growth potential for single-cell analysis products makes this reportparticularly timely.

SCOPE AND FORMAT

The scope of the report includes single-cell analysis technologies, applications,industries, major funding initiatives, patents and companies. The market sizes forsingle-cell products are given for the years 2014, 2015 and 2020.

This report reviews the single-cell workflow steps and technologies and providesbackground on why single-cell analysis is important. It then discusses some of the topresearch initiatives that are contributing to the growth of single-cell applications.Market driving forces are also discussed.The structure of several important industry subsectors are reviewed as well as majorindustry acquisitions and strategic alliances from 2013 to the present. Industrysubsectors analyzed include NGS instruments, droplet digital PCR, single-cellproteomics, target enrichment and amplification, single-cell DNA polymerase,preimplantation genetic diagnosis and screening, liquid biopsy and immunesequencing.

The market for single-cell analysis technologies is analyzed in depth. The market isanalyzed by end user, application, product type, field of use, analysis method, workflowstep and geography.The single-cell diagnostics market is analyzed by indication and by test purpose.Specific geographic markets are discussed, including North America, Europe,Asia-Pacific and the rest of the world (ROW).Market data covers the years 2014, 2015 and 2020.More than 75 companies in the single-cell analysis industry are profiled in this report.BCC Research provides a summary of the main industry acquisitions and strategicalliances from 2013 through 2015, including key alliance trends.

Table Of Contents

Single-Cell Genomics and Proteomics: Emerging Technologies and Markets
CHAPTER 1 INTRODUCTION 2
STUDY GOALS AND OBJECTIVES 2
REASONS FOR DOING THE STUDY 2
CONTRIBUTION OF THE STUDY AND FOR WHOM 3
SCOPE AND FORMAT 3
METHODOLOGY 4
INFORMATION SOURCES 4
ANALYST'S CREDENTIALS 4
RELATED BCC RESEARCH REPORTS 4
BCC RESEARCH WEBSITE 5
DISCLAIMER 5
CHAPTER 2 EXECUTIVE SUMMARY 7
SUMMARY TABLE GLOBAL SINGLE-CELL ANALYSIS MARKET BY END USER
INDUSTRY, THROUGH 2020 ($ MILLIONS) 7
SUMMARY FIGURE GLOBAL SINGLE-CELL ANALYSIS MARKET BY END USER
INDUSTRY, 2014-2020 ($ MILLIONS) 7
CHAPTER 3 OVERVIEW 10
INTRODUCTION 10
REPORT SCOPE 10
TABLE 1 KEY SINGLE-CELL ANALYSIS MARKET SEGMENTS COVERED 11
WORKFLOW 11
TABLE 2 SINGLE-CELL ANALYSIS WORKFLOW 11
TECHNOLOGY CHALLENGES 12
MARKETS 13
TABLE 3 GLOBAL SINGLE-CELL ANALYSIS MARKET BY APPLICATION FIELD,
THROUGH 2020 ($ MILLIONS) 13
GROWTH DRIVING FORCES 14
TABLE 4 SINGLE-CELL ANALYSIS MARKET GROWTH DRIVING FORCES 14
KEY TRENDS 15
TABLE 5 TRENDS IN SINGLE-CELL ANALYSIS 15
INDUSTRY 16
TABLE 6 SINGLE-CELL ANALYSIS INDUSTRY SUBSECTORS 16
CHAPTER 4 TECHNOLOGIES 19
WHAT MAKES SINGLE-CELL ANALYSIS UNIQUE 19
TABLE 7 UNIQUE TECHNICAL CHALLENGES OF SINGLE-CELL ANALYSIS 19
SINGLE-CELL ANALYSIS WORKFLOW 20
TABLE 8 SINGLE-CELL ANALYSIS WORKFLOW 20
CELL ISOLATION TECHNOLOGIES 20
TABLE 9 CELL DIFFERENTIATORS 21
TABLE 10 CELL ISOLATION TECHNOLOGIES 22
SAMPLE PREPARATION TECHNOLOGIES 23
TABLE 11 SINGLE-CELL SAMPLE PREPARATION TECHNOLOGIES 23
ANALYSIS TECHNOLOGIES 24
TABLE 12 SINGLE-CELL ANALYSIS TECHNOLOGIES 25
CHAPTER 5 SINGLE-CELL INITIATIVES 27
SINGLE-CELL RandD 27
TABLE 13 TOP-TEN SINGLE-CELL RESEARCH and DEVELOPMENT PROJECTS 27
ALLEN INSTITUTE OF CELL SCIENCE 28
CAMBRIDGE SINGLE-CELL ANALYSIS CORE FACILITY 28
CENTRE OF SINGLE-CELL BIOLOGY 28
NATIONAL CENTER FOR SINGLE-CELL BIOLOGY 28
MICROBIAL DARK MATTER PROJECT 28
SINGLE-CELL ANALYSIS CORE 29
SINGLE-CELL ANALYSIS PROGRAM 29
SINGLE-CELL ANALYSIS PROGRAM - TRANSRCIPTOME PROJECT 30
SINGLE-CELL FUNCTIONAL GENOMICS PROGRAM 30
SINGLE-CELL PROTEOMICS AND LIPIDOMICS PROJECT 30
CHAPTER 6 APPLICATIONS 32
INTRODUCTION 32
TABLE 14 SINGLE-CELL ANALYSIS - NEAR- TO MID-TERM APPLICATIONS 32
BASIC CELL BIOLOGY 32
TABLE 15 KEY OBJECTIVES OF BASIC SINGLE-CELL BIOLOGY 33
IMMUNOLOGY 33
MICROBIOLOGY 34
NEUROLOGY 34
ONCOLOGY 35
TABLE 16 SSA ANALYSIS TO IDENTIFY CANCER DRIVER MUTATIONS 35
STEM CELL BIOLOGY 36
TABLE 17 STEM CELLS TYPES 36
LIQUID BIOPSY 37
TABLE 18 BIOMARKERS IN LIQUID BIOPSY 37
TABLE 19 FACTORS IN TISSUE BIOPSY 38
PREIMPLANTATION GENETIC DIAGNOSIS AND SCREENING 39
TABLE 20 PREIMPLANTATION GENETIC DIAGNOSIS AND SCREENING APPLICATIONS 40
HUMAN IDENTIFICATION 40
AGRICULTURE 41
CHAPTER 7 SINGLE-CELL ANALYSIS INDUSTRY 43
INTRODUCTION 43
TABLE 21 KEY SEGMENTS WITHIN THE SINGLE-CELL ANALYSIS INDUSTRY 43
NGS INSTRUMENT INDUSTRY 44
TABLE 22 NEXT-GENERATION SEQUENCING INSTRUMENT COMPANIES SUMMARY 44
DROPLET DIGITAL PCR INDUSTRY 47
TABLE 23 ADVANTAGES OF DROPLET DIGITAL PCR FOR SINGLE-CELL ANALYSIS 47
TABLE 24 DROPLET DIGITAL PCR INDUSTRY 48
SINGLE-CELL PROTEOMICS INDUSTRY 49
TABLE 25 SINGLE-CELL PROTEOMICS INDUSTRY 49
TARGET ENRICHMENT AND AMPLIFICATION INDUSTRY 50
TABLE 26 SINGLE-CELL TARGET ENRICHMENT INDUSTRY 51
SINGLE-CELL DNA POLYMERASE INDUSTRY 52
TABLE 27 SINGLE-CELL DNA POLYMERASE INDUSTRY 53
PREIMPLANTATION GENETICS DIAGNOSIS AND SCREENING INDUSTRY 53
TABLE 28 PREIMPLANTATION DIAGNOSTICS PLATFORMS 54
TABLE 29 PREIMPLANTATION GENETIC DIAGNOSIS AND SCREENING INDUSTRY 55
LIQUID BIOPSY INDUSTRY 58
TABLE 30 LIQUID BIOPSY INDUSTRY 59
IMMUNE SEQUENCING INDUSTRY 66
TABLE 31 IMMUNE SYSTEM PROFILING INDUSTRY 66
CHAPTER 8 ACQUISITIONS AND STRATEGIC ALLIANCES 69
ACQUISITIONS 69
TABLE 32 SINGLE-CELL INDUSTRY ACQUISITIONS, JANUARY 2013 THROUGH
AUGUST 2015 69
STRATEGIC ALLIANCES 72
TABLE 33 SINGLE-CELL INDUSTRY STRATEGIC ALLIANCES, JANUARY 2013
THROUGH AUGUST 2015 72
CHAPTER 9 MARKETS 82
FORCES DRIVING GROWTH 82
TABLE 34 ANALYSIS OF FORCES DRIVING GROWTH OF THE SINGLE-CELL MARKET 82
SINGLE-CELL ANALYSIS TYPE MARKET 83
TABLE 35 GLOBAL SINGLE-CELL ANALYSIS MARKET BY ANALYSIS TYPE, THROUGH
2020 ($ MILLIONS) 83
SINGLE-CELL GENOMICS ANALYSIS MARKET BY TECHNOLOGY 85
TABLE 36 GLOBAL SINGLE-CELL GENOMICS ANALYSIS MARKET BY TECHNOLOGY,
THROUGH 2020 ($ MILLIONS) 85
SINGLE-CELL ANALYSIS END USER MARKETS 86
TABLE 37 GLOBAL SINGLE-CELL ANALYSIS MARKET BY END USER INDUSTRY,
THROUGH 2020 ($ MILLIONS) 86
SINGLE-CELL ANALYSIS WOKFLOW STEP MARKETS 87
TABLE 38 GLOBAL SINGLE-CELL ANALYSIS MARKET BY WORKFLOW STEP,
THROUGH 2020 ($ MILLIONS) 88
TABLE 39 GLOBAL SINGLE-CELL CELL ISOLATION ANALYSIS MARKET BY TYPE,
THROUGH 2020 ($ MILLIONS) 89
SINGLE-CELL ANALYSIS DIAGNOSTICS MARKETS 90
TABLE 40 GLOBAL SINGLE-CELL DIAGNOSTICS MARKET BY INDICATION, THROUGH
2020 ($ MILLIONS) 90
TABLE 41 GLOBAL SINGLE-CELL CANCER DIAGNOSTICS MARKET BY TEST PURPOSE,
THROUGH 2020 ($ MILLIONS) 91
TABLE 42 GLOBAL SINGLE-CELL CANCER DIAGNOSTICS MARKET BY INDICATION,
THROUGH 2020 ($ MILLIONS) 93
SINGLE-CELL ANALYSIS GEOGRAPHICAL MARKET 94
TABLE 43 GLOBAL SINGLE-CELL ANALYSIS MARKET BY GEOGRAPHY, THROUGH
2020 ($ MILLIONS) 94
CHAPTER 10 PATENTS 97
TABLE 44 SINGLE-CELL TECHNOLOGY PATENTS BY REGION, 2005-AUGUST 2015
(NO. OF PATENTS) 97
OF PATENTS) 98
CHAPTER 11 COMPANY PROFILES 101
OVERVIEW 101
10X GENOMICS 101
ACCELERATE DIAGNOSTICS INC. 101
AFFYMETRIX 102
AGILENT TECHNOLOGIES INC. 102
ANGLE PLC 104
APOCELL 105
ASURAGEN INC. 105
ATRECA INC. 106
AVIVA BIOSCIENCES 107
BECTON, DICKINSON AND CO. 107
BERRY GENOMICS CO. LTD. 108
BGI SHENZHEN 109
BIOARRAY S.L. 111
BIOCEPT INC. 111
BIOFLUIDICA INC. 112
BIO-RAD LABORATORIES INC. 112
BOREAL GENOMICS 113
CELGENE 114
CELL MICROSYSTEMS INC. 114
CELLULAR RESEARCH INC. 115
CHRONIX BIOMEDICAL 116
CIRCULOMICS INC. 116
CLONTECH LABORATORIES INC. 116
CYNVENIO BIOSYSTEMS INC. 117
CYTOTRACK APS 117
DANAHER CORP. 118
DENOVO SCIENCES INC. 119
DIAGNOLOGIX LLC 119
DNA ELECTRONICS LTD. 120
ENUMERAL 121
EPIC SCIENCES 121
EXOSOME DIAGNOSTICS INC. 122
FLUIDIGM CORP 123
FLUXION BIOSCIENCES INC. 123
GE HEALTHCARE 124
GENOMIC HEALTH INC. 125
GIGAGEN INC. 126
GOOD START GENETICS INC. 127
HTG MOLECULAR DIAGNOSTICS INC. 128
ILLUMINA INC. 128
TABLE 46 NEW PLATFORMS INTRODUCED BY ILLUMINA IN 2015 ($) 129
JOHNSON and JOHNSON 133
KELLBENX INC. 133
LABORATORY CORP. OF AMERICA INC. 134
MERCK KGAA 136
NATERA INC. 136
NEW ENGLAND BIOLABS 137
NEW ONCOLOGY AG 138
NODALITY INC. 138
NUGEN TECHNOLOGIES INC. 139
OXFORD GENE TECHNOLOGY 139
OXFORD NANOPORE TECHNOLOGIES LTD. 140
PACIFIC BIOSCIENCES OF CALIFORNIA INC. 141
PERKIN ELMER INC. 143
PERSONAL GENOME DIAGNOSTICS INC. 144
PGXL LABORATORIES 144
PICOSEQ 145
QIAGEN NV 145
RAINDANCE TECHNOLOGIES INC. 148
RARECELLS SAS 149
RARECYTE INC. 149
REPRODUCTIVE HEALTH SCIENCE PTY LTD 150
REPROGENETICS 150
RESOLUTION BIOSCIENCE INC. 151
ROCHE HOLDING AG 151
TABLE 47 COMMERCIAL SEQUENCER COMPETITIVE POSITIONING 153
RUBICON GENOMICS 154
SCREENCELL 155
SENGENICS INTERNATIONAL PTE LTD. 155
SEQUENOM INC. 156
SILICON BIOSYSTEMS 157
SPHERE FLUIDICS LTD. 157
STRATEC BIOMEDICAL AG 158
SYGNIS AG 158
THERMO FISHER SCIENTIFIC INC. 159
THORNE DIAGNOSTICS INC. 160
TROVAGENE INC. 160
VITATEX INC. 161
WAFERGEN BIO-SYSTEMS INC. 162
TABLE 48 WAFERGEN STRATEGIC ALLIANCES 162
YIKON GENOMICS CO. LTD. 163
ZEPHYRUS BIOSCIENCES INC. 164

LIST OF TABLES
SUMMARY TABLE GLOBAL SINGLE-CELL ANALYSIS MARKET BY END USER INDUSTRY,
THROUGH 2020 ($ MILLIONS) 7
TABLE 1 KEY SINGLE-CELL ANALYSIS MARKET SEGMENTS COVERED 11
TABLE 2 SINGLE-CELL ANALYSIS WORKFLOW 11
TABLE 3 GLOBAL SINGLE-CELL ANALYSIS MARKET BY APPLICATION FIELD, THROUGH
2020 ($ MILLIONS) 13
TABLE 4 SINGLE-CELL ANALYSIS MARKET GROWTH DRIVING FORCES 14
TABLE 5 TRENDS IN SINGLE-CELL ANALYSIS 15
TABLE 6 SINGLE-CELL ANALYSIS INDUSTRY SUBSECTORS 16
TABLE 7 UNIQUE TECHNICAL CHALLENGES OF SINGLE-CELL ANALYSIS 19
TABLE 8 SINGLE-CELL ANALYSIS WORKFLOW 20
TABLE 9 CELL DIFFERENTIATORS 21
TABLE 10 CELL ISOLATION TECHNOLOGIES 22
TABLE 11 SINGLE-CELL SAMPLE PREPARATION TECHNOLOGIES 23
TABLE 12 SINGLE-CELL ANALYSIS TECHNOLOGIES 25
TABLE 13 TOP-TEN SINGLE-CELL RESEARCH and DEVELOPMENT PROJECTS 27
TABLE 14 SINGLE-CELL ANALYSIS - NEAR- TO MID-TERM APPLICATIONS 32
TABLE 15 KEY OBJECTIVES OF BASIC SINGLE-CELL BIOLOGY 33
TABLE 16 SSA ANALYSIS TO IDENTIFY CANCER DRIVER MUTATIONS 35
TABLE 17 STEM CELLS TYPES 36
TABLE 18 BIOMARKERS IN LIQUID BIOPSY 37
TABLE 19 FACTORS IN TISSUE BIOPSY 38
TABLE 20 PREIMPLANTATION GENETIC DIAGNOSIS AND SCREENING APPLICATIONS 40
TABLE 21 KEY SEGMENTS WITHIN THE SINGLE-CELL ANALYSIS INDUSTRY 43
TABLE 22 NEXT-GENERATION SEQUENCING INSTRUMENT COMPANIES SUMMARY 44
TABLE 23 ADVANTAGES OF DROPLET DIGITAL PCR FOR SINGLE-CELL ANALYSIS 47
TABLE 24 DROPLET DIGITAL PCR INDUSTRY 48
TABLE 25 SINGLE-CELL PROTEOMICS INDUSTRY 49
TABLE 26 SINGLE-CELL TARGET ENRICHMENT INDUSTRY 51
TABLE 27 SINGLE-CELL DNA POLYMERASE INDUSTRY 53
TABLE 28 PREIMPLANTATION DIAGNOSTICS PLATFORMS 54
TABLE 29 PREIMPLANTATION GENETIC DIAGNOSIS AND SCREENING INDUSTRY 55
TABLE 30 LIQUID BIOPSY INDUSTRY 59
TABLE 31 IMMUNE SYSTEM PROFILING INDUSTRY 66
TABLE 32 SINGLE-CELL INDUSTRY ACQUISITIONS, JANUARY 2013 THROUGH AUGUST
2015 69
TABLE 33 SINGLE-CELL INDUSTRY STRATEGIC ALLIANCES, JANUARY 2013 THROUGH
AUGUST 2015 72
TABLE 34 ANALYSIS OF FORCES DRIVING GROWTH OF THE SINGLE-CELL MARKET 82
TABLE 35 GLOBAL SINGLE-CELL ANALYSIS MARKET BY ANALYSIS TYPE, THROUGH
2020 ($ MILLIONS) 83
TABLE 36 GLOBAL SINGLE-CELL GENOMICS ANALYSIS MARKET BY TECHNOLOGY,
THROUGH 2020 ($ MILLIONS) 85
TABLE 37 GLOBAL SINGLE-CELL ANALYSIS MARKET BY END USER INDUSTRY,
THROUGH 2020 ($ MILLIONS) 86
TABLE 38 GLOBAL SINGLE-CELL ANALYSIS MARKET BY WORKFLOW STEP, THROUGH
2020 ($ MILLIONS) 88
TABLE 39 GLOBAL SINGLE-CELL CELL ISOLATION ANALYSIS MARKET BY TYPE,
THROUGH 2020 ($ MILLIONS) 89
TABLE 40 GLOBAL SINGLE-CELL DIAGNOSTICS MARKET BY INDICATION, THROUGH
2020 ($ MILLIONS) 90
TABLE 41 GLOBAL SINGLE-CELL CANCER DIAGNOSTICS MARKET BY TEST PURPOSE,
THROUGH 2020 ($ MILLIONS) 91
TABLE 42 GLOBAL SINGLE-CELL CANCER DIAGNOSTICS MARKET BY INDICATION,
THROUGH 2020 ($ MILLIONS) 93
TABLE 43 GLOBAL SINGLE-CELL ANALYSIS MARKET BY GEOGRAPHY, THROUGH 2020
($ MILLIONS) 94
TABLE 44 SINGLE-CELL TECHNOLOGY PATENTS BY REGION, 2005-AUGUST 2015 (NO.
OF PATENTS) 97
TABLE 45 SINGLE-CELL PATENTS BY WORKFLOW STEP, 2005-AUGUST 2015 (NO. OF
PATENTS) 98
TABLE 46 NEW PLATFORMS INTRODUCED BY ILLUMINA IN 2015 ($) 129
TABLE 47 COMMERCIAL SEQUENCER COMPETITIVE POSITIONING 153
TABLE 48 WAFERGEN STRATEGIC ALLIANCES 162

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