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Rheumatoid Arthritis: KOL Insight

  • March 2016
  • Firstword Pharma
Report ID: 3509579


Table of Contents

Leading brands under threat as biosimilars and new pipeline drugs hit the market

Key opinion leaders (KOLs) say Rheumatoid Arthritis (RA) treatment is in for a shakeup thanks to anti-TNF biosimilars, new JAK inhibitors, and in the longer-term, other innovative pipeline drugs. Good news for doctors and patients, but what will it mean for the leading brands?

Find out in FirstWord’s KOL Insight: Rheumatoid Arthritis report.

Covering 9 marketed RA drugs, and 7 pipeline drugs currently in clinical trials, this 98-page report gives you an in-depth look at how 12 KOLs in North America and Europe see the RA landscape.

You’ll get KOLs’ candid thoughts on how new drugs will affect the treatment paradigm, whether they’ll challenge established brands, and how doctors and payers will make key treatment and reimbursement decisions.

View: North American KOLs, EU KOLs, marketed drugs, pipeline drugs

Plus: Order the report today and you’ll also receive three quarterly FirstWord Therapy Trends Update Bulletins absolutely free!

Answering key questions

Marketed Drugs

Humira (adalimumab; AbbVie): Do KOLs think Humira's new formulation is enough to protect it against biosimilar adalimumab?
Enbrel (etanercept; Amgen/Pfizer): How will recently approved etanercept biosimilar, Benepali affect Enbrel’s leading position in the European market?
Remicade (infliximab; Janssen Biotech/Merck & Co): How much of an effect has biosimilar infliximab had on Remicade in Europe?
Simponi (golimumab; Janssen Biotech/Merck & Co): What’s preventing greater uptake of Simponi in the US?
Cimzia (certolizumab pegol; UCB): How likely are biosimilar adalimumab and biosimilar etanercept to threaten Cimzia’s market share?
Actemra/RoActemra (tocilizumab; Roche): Are US doctors following Europe’s lead and changing the way they use Actemra/RoActemra?
Orencia (abatacept; Bristol-Myers Squibb): Are pipeline drugs likely to affect Orencia’s position in the treatment paradigm?

Xeljanz (tofacitinib; Pfizer): How do KOLs expect Xeljanz to fare against pipeline JAK inhibitor, baricitinib?

Pipeline Drugs

Benepali (Samsung Bioepis): Will Benepali impact branded anti-TNFs?
sarilumab (SAR 153191; REGN 88; Sanofi/Regeneron): How do KOLs see the SARIL-RA-MONARCH trial?
sirukumab (CNTO 136; Janssen/GlaxoSmithKline): How will the factors dictating choice of IL6 inhibitors differ in North America and Europe?
secukinumab (AIN 457; Novartis): Do KOLs see anti-IL17 drugs like secukinumab as promising treatments for RA?
baricitinib (INCB 28050, LY 3009104; Incyte/Eli Lilly): How do KOLs view baricitinib’s safety profile compared to Xeljanz’s?
peficitinib (ASP 015K; Astellas): Peficitinib is an oral JAK3 inhibitor - how do KOLs view JAK3 inhibition?
ABT 494 (AbbVie): After seeing its Phase II trial results, are KOLs optimistic about ABT 494?
GP2015 (Novartis): What do KOLs think about prescribing GP2015 for RA?
mavrilimumab (CAM 3001; AstraZeneca/MedImmune): What do KOLs think about mavrilimumab’s novel mechanism of action?

Top Takeaways

Big changes ahead: Find out how the triple-threat of biosimilars, pipeline drugs, and shifts in the treatment paradigm is shaking up the formerly quiet RA market.
Biosimilars threaten branded anti-TNFs: KOLs predict that biosimilars—e.g., recently approved Benepali—will have a big impact on branded anti-TNFs. Are any of the major players safe?
Other biologics also affected: Maybe not by biosimilars, but pipeline drugs are likely to challenge some mainstay biologics. Find out which ones are most at risk.
New JAK inhibitors threaten Xeljanz: Find out what KOLs think will dictate competition among JAK inhibitors, and whether Xeljanz can hold on to its first-to-market advantage.
Moving up or staying put: See which RA drugs are moving up the treatment paradigm, which aren’t, and how pipeline drugs are likely to affect them.
Pipeline drugs a mixed bag: KOLs are excited about some pipeline therapies, lukewarm about others, and in wait-and-see mode about the rest. How do they see your brand?
New MoAs showing promise: KOLs are optimistic about some pipeline drugs’ newer mechanisms of action. Discover which ones, and why.

Key issues explored

Hunger for new treatments: The prospect of lower prices and better patient access has KOLs enthusiastic about biosimilars and pipeline drugs.
Changing treatment paradigm: The RA treatment paradigm is already changing, and KOLs expect pipeline drugs to change it further in the next decade. Find out how.
Payer power: In the US, at least, payers have a big influence on prescription decisions. Learn how KOLs think that will affect new RA treatments.
Uptake will be different in US and Europe: Learn whether KOLs expect the US or European market to be more difficult for new drugs to penetrate.
Phase III trials eagerly anticipated: KOLs are cautiously optimistic about newer pipeline drugs but want Phase III data before drawing any conclusions. Which trials are most important?
Interest in more selective treatments: Find out whether KOLs expect more selective JAK inhibitors to offer better safety and efficacy.
Using extrapolated data: Some biosimilars’ clinical data comes from studies in other disease areas. Are KOLs comfortable extrapolating that data to RA?

A report based on expert knowledge
We interviewed 12 KOLs from North America and Europe between 02/12/2015 and 08/01/2016.

North American KOLs

Prof Michael E Weinblatt, MD. Professor of Medicine, Harvard Medical School; Co-director, Clinical Rheumatology, Brigham and Women's Hospital, Boston, MA, USA.
Dr Rohit Aggarwal, MD. Assistant Professor of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Prof Eric L Matteson, MD. Professor of Medicine and Chair of the Department of Rheumatology, Mayo Clinic, Rochester, MN, USA.
Dr Petros Efthimiou, MD. Associate Chief of Rheumatology, New York Methodist Hospital; Associate Professor of Medicine and Rheumatology, Weill Cornell Medical College, New York, NY, USA.
Dr Yousaf Ali, MD. Associate Professor of Medicine, Division of Rheumatology, Mount Sinai Medical Center, New York, NY, USA.
Dr Michael H Weisman, MD. Director, Division of Rheumatology, Cedars-Sinai, West Hollywood, CA, USA.

European KOLs

Prof Ingrid M'ller. Director and Consultant in Rheumatology and Musculoskeletal Sonography, Institut Poal of Rheumatology, Barcelona, Spain.
Anonymous. Professor of Internal Medicine and Rheumatology at a leading teaching hospital, Germany.
Anonymous. Professor at a leading university hospital, Germany.
Professor Arnaud Constantin. Consultant Physician, Rheumatologist, and university lecturer, University Hospital Toulouse; member of clinical research, Toulouse hospital, Toulouse, France.
Dr Jean David Cohen. Consultant Physician, Rheumatologist, University hospital Montpellier, Montpellier, France.
Dr Andrew Brown. Consultant Rheumatologist, York Teaching Hospital NHS Foundation Trust; Senior Lecturer, Medical Education and Rheumatology, Hull York Medical School, York, UK.

Ongoing Benefits
The world of pharma is ever changing and executives must always be up-to-date with new developments that could affect their own products, position and research. That is why FirstWord's guarantee to keep Therapy Trends clients up to date with Update Bulletins offers a real commercial advantage.
Update Bulletins include expert insight and analysis based on FirstWord analyst re-engagement with the KOLs after major events such as product approvals, key data releases and major conferences to deliver the most valuable insights with each update.
Your Therapy Trends Report purchase entitles you to receive three Update Bulletins, which are published approximately every three months for 12 months following the report's publication date.
You will receive a copy of each Update Bulletin once available, which are issued each quarter after the publication date.

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