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Chronic Lymphocytic Leukaemia: KOL Insight

  • September 2015
  • -
  • Firstword Pharma

In the last few years the emergence of new targeted therapies such as AbbVie’s/Janssen’s kinase inhibitor Imbruvica (ibrutinib) and Gilead’s P13K inhibitor Zydelig (idelalisib) have delivered effective therapies to previously underserved markets. Yet the arrival of AbbVie’s/Roche’s venetoclax looks to be a further game changer with its ability to induce complete remissions within a fixed treatment window. What impact will this new therapy have on the competitive landscape? How might it change the treatment paradigm and how do KOLs see it changing clinical practice?

This comprehensive report reveals critical insights from 12 leading North American and European KOLs – see who they are. Find outhow they view the clinical benefits of current and late stage products, potential drug combinations, and the patient’s condition state and financial concerns that determine therapy choice. See what marketed and pipeline drugs are discussed in the report - click here

Answering key questions

With biosimilar rituximab on the horizon, can Roche successfully protect Rituxan/MabThera revenues, and if so, how?
What combinations are seen by KOLs as key to Roche’s Gazyva/Gazyvaro (obinutuzumab) future competitiveness?
Is there a place for Novartis’ Arzerra (ofatumumab) in the treatment paradigm. And if so, where does it fit in?
While AbbVie’s/Janssen’s Imbruvica (ibrutinib) dominates the market for patients with relapsed or refractory CLL, the high cost and indefinite duration of treatment is limiting growth – how can AbbVie/Janssen respond as competition grows?
What are the prospects for Infinity’s/AbbVie’s duvelisib and Celgene’s lenalidomide pipeline therapies?
Where do KOLs see Roche’s/AbbVie’s impressive venetolax (ABT-199) finding a place in the treatment paradigm now and in the future
How might the treatment algorithm for high-risk CLL patients with the TP35 defect change and which therapies could move into the first-line setting?

Key issues explored

Critical factors affecting prescribing decisions: Know the detailed opinions of the leading KOLs on current and late stage CLL therapies and what they see as the critical clinical advantages/disadvantages affecting their decision to prescribe
The significance of genetic risk factors: Appreciate the role genetic risk factors and co-morbidities play in determining treatment choice and identify key areas for strategic and tactical action
Combination therapies and the treatment paradigm: Understand how combination therapy fits into the treatment paradigm and identify the products that will be positively or adversely affected
Exclusive KOL opinion into current clinical trials: Review KOL attitudes to recently completed or ongoing clinical trials such as HELIOS, CLL11, COMPLEMENT 1 and RESONATE-2

Key Takeaways

Formulate effective strategies for product positioning, pricing and clinician messaging
Map new treatment options to CLL patients and patient sub-groups and identify niche opportunities
Identify product attributes and patient characteristics that the KOLs think are the most important in terms of prescribing decisions and position in the treatment algorithm
Appreciate the growing concern with drug prices and the negative effect it is having on uptake
Discover which clinical trials the KOLs believe will have a significant impact on future treatment decisions and their likely outcomes
Evaluate the changing and challenging competitive landscape as wider clinical adoption and experience with new products impacts prescribing choice

Features of the report

Knowledgeable “real-world” opinions of leading US and European KOLs that is not available in any other report
Detailed and candid views on the future positioning and competitiveness of current and upcoming CLL therapies
Essential insights that answer critical business questions and provide a platform for strategic planning and tactical engagement.

KOL Panel

KOLs from North America:

Steve Coutre, MD, Professor Hematologist, Stanford Cancer Center, Stanford, CA, USA.
Bruce Cheson, MD, FACP, FAAS, Professor of Medicine, Georgetown University Hospital, Lombardi Comprehensive Cancer Center, Washington DC, USA.
Steven T. Rosen, MD, provost and chief scientific officer for City of Hope, Duarte, CA, USA.
Farhad Ravandi, MD, Professor and Chief, Section of Developmental Therapeutics within the Department of Leukemia, Division of Cancer Medicine at MD Anderson, Houston, TX, USA.
David Spaner, MD, FRCPC, PhD, Associate Professor and Senior Scientist Sunnybrook Health Sciences Centre, Odette Cancer Centre, University of Toronto, Canada.
Anonymous US KOL, Associate Professor of Haematology in the Division of Medical Haematology at a large US academic medical center.

KOLs from Europe:

Christopher Fegan Clinical Professor, Institute of Cancer & Genetics, Cardiff University School of Medicine, Cardiff, UK.
Anonymous German KOL, Associate Professor and deputy chairman at the Department of Internal Medicine (Haematology, Oncology, Rheumatology and Infectious Diseases) at a University in Germany.
Anonymous German KOL, Assistant professor and consultant at a large university hospital, Germany.
Paolo Ghia, MD, Associate Professor in Internal Medicine at the Università Vita-Salute San Raffaele; and Deputy Chairman of the Division of Experimental Oncology, San Raffaele Scientific Institute, Italy.
Fortunato Morabito, Contract professor for the Clinical Pathology Specialization program of the Faculty of Pharmacy, University of Calabria, Italy.
Marco Montillo, MD, Director of Chronic Lymphoproliferative Disorders Program at the Department of Hematology of Niguarda Cancer Center, Niguarda Cà Granda Hospital in Milan, Italy.

Get detailed KOL views on:


Marketed drugs
Rituxan/MabThera (rituximab; Roche/Genentech/Biogen)
Gazyva/Gazyvaro (obinutuzumab; Roche)
Arzerra (ofatumumab; Novartis)
Campath/MabCampath (alemtuzumab; Sanofi)
Pipeline drugs
ublituximab (TG-1101; TG Therapeutics)


Marketed drugs
Imbruvica (ibrutinib; AbbVie/Janssen Biotech)
Zydelig (idelalisib; Gilead Sciences)
Pipeline drugs
venetoclax (ABT-199; Roche/AbbVie)
duvelisib (IPI-145; Infinity/AbbVie)
Revlimid (lenalidomide; Celgene)

Table Of Contents

Chronic Lymphocytic Leukaemia: KOL Insight
1.Executive summary 1
2.Research Objectives 3
3.Research Focus 5
4.Chemotherapy Overview 13
5.Monoclonal antibodies 14
5.1.Marketed drugs 15
5.2.Rituxan/MabThera (rituximab; Roche/Biogen Idec) 15
5.3.Gazyva/Gazyvaro (obinutuzumab; Roche) 28
5.4.Arzerra (o

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