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Nano-based science paving the precision medicine era

The continued development of new treatments associated with the demographic trends and public health considerations is remarkable. Nanotechnology has been identified as one most relevant key enabling technologies of the last ten years, significantly impacting on many different biomedical developments in a broad spectrum of applications therapeutics, diagnostics, theranostics, medical imaging, regenerative medicine, life sciences research and biosciences, among many others. In fact, nanomedicine is present in all therapeutic areas, exhibiting a perceptible and extensive impact in the treatment and diagnosis of some most concerned diseases.

Innovation in nanomedicine fields has played a major role in the improvement of both length and quality of life during the present decade, appreciably advocated to reduce the disease burden for individuals and the society through completely new or improved diagnostic and therapeutic methods. Groundbreaking advances in the scientific understanding of the underlying mechanisms of disease are paving the way for nanomedicine on precision medicine topics.

Frost & Sullivan (www.frost.com/techvision) identified an unprecedented behavior in terms of innovation in nanomedicine fields, with notable acceptance in diagnostics, therapeutics, companion diagnostics, regenerative medicine, and many other applications that are undoubtedly linked to the concept of precision medicine. Nanomedicine enables personalized medicine approaches in many ways. As an instance, nano-based diagnostic tests or nano-imaging diagnosis may help to the stratification of patients and thereby to guarantee a most personalized, patient-centered therapy. In addition, clinical protocols become simpler, more efficient and less costly.

Research Scope
The continued development of new treatments associated with the demographic trends and public health considerations is remarkable. Nanotechnology has been identified as one most relevant key enabling technologies of the last ten years, significantly impacting on many different biomedical developments in a broad spectrum of applications therapeutics, diagnostics, theranostics, medical imaging, regenerative medicine, life sciences research and biosciences, among many others. In fact, nanomedicine is present in all therapeutic areas, exhibiting a perceptible and extensive impact in the treatment and diagnosis of some most concerned diseases.

Innovation in nanomedicine fields has played a major role in the improvement of both length and quality of life during the present decade, appreciably advocated to reduce the disease burden for individuals and the society through completely new or improved diagnostic and therapeutic methods. Groundbreaking advances in the scientific understanding of the underlying mechanisms of disease are paving the way for nanomedicine on precision medicine topics.

This research service (RS) depicts the current landscape and the new trends in nanomedicine development, focusing on:
- Technology trends and capability
- Stakeholder activities, influence, industry initiatives and applications targeted
- Industry initiatives, regulation, standardization approaches for tackling challenges
- Technology benchmarking for specific applications
An appendix is included, comprising lists with major participants in the study and most notable patents in the field

Key Findings
The Nanomedicine Landscape
Main observations related to the present role of nanomedicine in the healthcare sector
- Innovation in nanomedicine fields has found notable acceptance in diagnostics, therapeutics, companion diagnostics, regenerative medicine, and many other applications that are undoubtedly linked to the concept of precision medicine. Nanomedicine enables personalized medicine approaches in many ways. As an instance, nano-based diagnostic tests or nano-imaging diagnosis may help to the stratification of patients and thereby to guarantee a most personalized, patient-centered therapy. In addition, clinical protocols become simpler, more efficient and less costly.
- In order to effectively reach the new precision medicine era, an strict observation of the principal behaviors, exhibiting close and well updated interactions between all the participants in the nanomedicine research and development (R&D) landscape, including academic, industrial, public and private partners, is crucially needed.
- Similarly, the articulation among different stakeholders, with aim to actively facilitate their communication and collaboration, including regulatory bodies and agencies, play a significant role in the effective translation and commercialization of nanomedicine developments, maximizing resources, synergy and cooperation.
- The nanomedicine ideal scenario proposes the framework of a competitive value chain constituted by innovative small and medium enterprises (SMEs) carrying out the first tests and the initial clinical proof of concept (PoC) of novel developments in nanomedicine up to phase I or IIa, to then derive in a effective transfer of such PoC projects to large companies, probably better financially and technically prepared to bring them onto the global market.
- The United States (US) are leading this strategy, followed by the European Commission (EC) countries, underpinning new developments in one of the fastest growing sectors for new drugs over the last two decades.
This strategy is very allied to the concepts of open innovation (OI) and smart specialization (SS).

Table Of Contents

Trends in Nanomedicine - Technology Benchmarking and Innovator Analysis
1. EXECUTIVE SUMMARY

Executive Summary
Research Scope
Research Methodology
Key Findings

2. TECHNOLOGY SNAPSHOT AND TRENDS

Technology Snapshot and Trends
Industry Value Chain and Business Model
Core Technology Applications
Technology Evolution
Core Growth Opportunities
Technology Synergy and Nanobiotechnology
Technology Roadmap
Industry Drivers and Restraints
Industry Technical and Business Challenges
Market Drivers and Restraints
Technology Drivers and Restraints
Porter's Five Forces Analysis

3. INDUSTRY MODELS AND APPLICATIONS TARGETED

Industry Models and Applications Targeted
Nanomedicine Innovation Model
Nanomedicines Application Focus
Nanomedicines Therapeutics Focus
Nanomedicines Diagnostics Focus
Nanomedicines Regenerative Medicine Focus

4. PRODUCT DEVELOPMENT AND MARKET POTENTIAL

Product Development and Market Potential
Nanomedicine Multiple Segmentation
Nanomedicines Principal Industry Facts
Nanomedicine Development Pipeline
Nanomedicine Products by Developmental Phase
Global Nanomedicine Market
Product Pipeline

5. KEY STAKEHOLDER ANALYSIS

Key Stakeholder Analysis
Nanomedicine Marketed Products
Key Companies in North America
Key Companies in North America
Key Companies in Europe
Key Companies in Asia Pacific
Intellectual Property

6. TECHNOLOGY BENCHMARKING

Technology Benchmarking
Multicriteria Approach for Benchmarking
Final Remarks
Legal Disclaimer

7. APPENDIX

Appendix
Key Contacts
Intellectual Property Sources
Key Patents

8. THE FROST and SULLIVAN STORY

The Frost and Sullivan Story
Value Proposition: Future of Your Company and Career
Global Perspective
Industry Convergence
360º Research Perspective
Implementation Excellence
Our Blue Ocean Strategy

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