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Impact of Genome Editing Techniques

  • December 2015
  • -
  • Frost & Sullivan
  • -
  • 72 pages

Breakthrough innovations across agriculture and human therapeutics

Improvements and new gene editing techniques are constantly that have a high disruptive and revolutionary impact within the application for healthcare and other verticals. Accurate and highly precise manners of manipulating genetic content has not been present until the recent developments across the space of gene editing techniques. These tools, that have been developed can effectively provide researchers with the capacity to understand disease and potentially cure it. It also has the potential to impact the production rate and quality of agricultural and livestock products.

Recent developments across genome editing technologies have resulted in the creation of next generation nucleases, that have higher levels of accuracy when correcting genetic mutations and defects. The classes under the genome editing technologies are the 4 broad families of nucleases: ZFNs, TALENs, CRISPR/Cas9, and Meganucleases. Though there are non-nuclease-based approaches and various proprietary gene editing techniques, the industry favorites are still the nuclease-based approaches.

Gene editing technologies have an impact across multiple applications areas including plant and animal genetic engineering. However, the area of most disruption is across human cell line engineering, which enables the development of next generations therapies and drugs. However, the agricultural industry has seen more success with gene editing techniques largely due to the less stringent regulatory environment.

From a regional standpoint, the United States of America, has currently contributed the most toward the development of these unique and highly beneficial techniques. While Europe and Asia are closely following with increased investments entering these regions through partnership agreements.

Research Scope
Improvements and new gene editing techniques are constantly that have a high disruptive and revolutionary impact within the application for healthcare and other verticals. Accurate and highly precise manners of manipulating genetic content has not been present until the recent developments across the space of gene editing techniques. These tools, that have been developed can effectively provide researchers with the capacity to understand disease and potentially cure it. It also has the potential to impact the production rate and quality of agricultural and livestock products. Recent developments across genome editing technologies have resulted in the creation of next generation nucleases, that have higher levels of accuracy when correcting genetic mutations and defects. The classes under the genome editing technologies are the 4 broad families of nucleases: ZFNs, TALENs, CRISPR/Cas9, and Meganucleases. Though there are non-nuclease-based approaches and various proprietary gene editing techniques, the industry favorites are still the nuclease-based approaches.

Gene editing technologies have an impact across multiple applications areas including plant and animal genetic engineering. However, the area of most disruption is across human cell line engineering, which enables the development of next generations therapies and drugs. However, the agricultural industry has seen more success with gene editing techniques largely due to the less stringent regulatory environment. From a regional standpoint, the United States of America, has currently contributed the most toward the development of these unique and highly beneficial techniques. While Europe and Asia are closely following with increased investments entering these regions through partnership agreements.

This research service brings out the impact of gene editing techniques on a global scale, through a detailed strategic assessment of the industry environment, including:
- Technology overview and comparison of technological capabilities between various gene editing techniques.
- Impact of gene editing across multiple applications areas such as agriculture, cosmetics, human therapeutics, animal models and livestock cultivation.
- Industry best practices and strategic insights, measuring performance, assessment of partnerships and alliances as well as detailed company profiles and breakthrough innovations.

Where does gene editing stand today?
Gene editing technologies are promising a radical change across the biotechnology community. Every instance when the medical and research community discovered a potentially radical technology that could revolutionize the development of therapeutics, it has resulted in the awakening of the entire stakeholder value chain. This usually leads to the establishment of multi-billion dollar franchise that comprises of venture capitals, biotechnology start-ups, numerous collaborations between university and industry participants. The role of gene editing has been vital across multiple domain areas such as agriculture, veterinary sciences, and also human health and therapeutic research and development. Recently, there has been significant speculation on the ethical and social implications of using certain gene editing techniques like the simple, yet effective CRISPR approach.

Owing to the developments and high level of speculation, as well as large the avid support for and against the utilization of gene editing techniques, an international summit on gene editing was conducted by the National Academies in the United States of America. This event saw the presence of other major national academics, the Royal Society of London and the Chinese Academy of Sciences. The entire summit was spent discussing the progress as well as the future impact that these technologies would have in human health. It culminated with the motivation to move forward in using these techniques, however, with proper
regulatory frameworks as well as a holding off on the clinical use of gene editing for germline manipulation.

Table Of Contents

Impact of Genome Editing Techniques
1. EXECUTIVE SUMMARY

Executive Summary
Research Scope

2. SNEAK PEAK-GENE EDITING

Sneak Peak-Gene editing
Where does gene editing stand today?
Segmentation-Application Overview
Segmentation-Technology overview

3. TECHNOLOGY OVERVIEW

Technology Overview
Main technology areas of focus enabling gene editing
Other technologies enabling gene editing
Technology capability
Technology capability : Comparative assessment
Approach : Technology Readiness Level (TRL)
TRL: ZFNs
TRL: TALENs
TRL: CRISPR/Cas9

4. INDUSTRY INITIATIVES AND MARKET IMPACT

Industry Initiatives and Market Impact
Market Impact of Technology/Business Accelerators
Market Impact of Technology/Business Challenges
Innovation Ecosystem: Key Innovators
Agriculture-Plant-based applications
Player assessment across application
Breakthrough's using gene editing technologies
Industrial bio-based applications
Player assessment across application
Breakthrough's using gene editing technologies
Gene edited animal-based applications
Player assessment across application
Breakthrough's using gene editing technologies
Human therapeutics applications
Player assessment across application
Utilization of Gene editing
Breakthrough's using gene editing technologies
Breakthrough's using gene editing technologies
Stakeholder Assessment
Partnership Assessment

5. OPPORTUNITY ASSESSMENT AND TECHNOLOGY ROADMAP

Opportunity Assessment and Technology Roadmap
Approach-Company Profile
Editas Medicine
Intellia Therapeutics
CRISPR Therapeutics
Caribou
Regulatory Landscape
Geographic Assessment
Technology Roadmap

6. PATENT ANALYSIS

Patent Analysis
Patent search Scope
Patent Publishing Trends, Global, 2010-15*
Top 20 Patent holders, Global, 2010- 15*
Patents per Source Jurisdiction (Top 10 Patent offices), Global, 2010-15*

7. KEY CONTACTS

Key Contacts

8. THE FROST and SULLIVAN STORY

The Frost and Sullivan Story
Legal Disclaimer
Value Proposition: Future of Your Company and Career
Global Perspective
Industry Convergence
360º Research Perspective
Implementation Excellence
Our Blue Ocean Strategy

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