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RNA Sequencing: Technologies and Global Markets

  • March 2016
  • -
  • BCC Research
  • -
  • 135 pages

This BCC Research report provides an overview of the current and future states of the RNA Sequencing (RNA Seq) market for the years 2015, 2016 and 2020 in segments such as instruments, tools and reagents, data analysis, and services.

Use this report to:

Analyze various segments of the RNA-Sequencing market such as RNA-Sequencing tools and reagents, RNA-Sequencing data analysis, and RNA-Sequencing services
Identify the main factors affecting each segment and forecast their market growth, future trends and product development
Evaluate infrastructure for the health and growth of the RNA-Sequencing market as a whole

Highlights

The global RNA-Sequencing market reached nearly $1.1 billion in 2015, and should reach $1.2 billion in 2016 and $2.1 billion in 2020, registering a compound annual growth rate CAGR) of 14.9%.
The tools and reagents segment should reach over $1.0 billion in 2020 from $566.8 million in 2015, a CAGR of 13.0%.
The services segment should reach $460.5 million by 2020 from $170.5 million in 2015, a CAGR of 9.1%.

STUDY GOALS AND OBJECTIVES

This BCC Research report, RNA Sequencing: Technologies and Global Markets, provides an overview of the current and future states of the RNA Sequencing (RNA-Seq) market for the years 2015, 2016 and 2020 in the following segments: instruments, tools and reagents, data analysis, and services. Special emphasis is placed on RNA-Seq technology development because RNA-Seq depends on the development of new and improved high throughput sequencing technologies.

This report describes the available technologies and the major players currently working in the market, as well as detailed analysis of the competitive environments, including new or potential trends in research and product development. This report also includes information regarding opportunities and obstacles affecting this market and its different sectors.

Each of the four RNA-Seq segments has healthy growth potential. Each of them also face serious and unique challenges. This report has a comprehensive discussion of technologies as well as the competitive landscape in the global market. It is designed to aim companies in their strategic planning efforts for exploiting RNA-Seq industry opportunities.

REASONS FOR DOING THE STUDY

RNA-Seq, introduced around 2010, is a method for transcriptomics. In a few short years, it has become the method of choice for transcriptome studies, rapidly replacing another transcriptomics method; the microarray. Transcriptomics is the study of transcriptome, the complete set of RNA transcripts that are produced by the genome, under specific circumstances or in a specific cell, using high-throughput methods.

RNA-Seq not only provides benefits to the scientific research community, but also has huge clinical potential in diagnostics and drug discovery. The RNA-Seq industry is an emerging, evolving and important biomedical sector; a comprehensive and critical study about its technologies and markets is needed for better understanding.

SCOPE AND FORMAT

The geographic scope is global. The RNA-Seq market is complex, consisting of a number of different segments. The market segments are: RNA-Seq instruments; RNA-Seq tools and reagents; RNA-Seq data analysis and RNA-Seq services. Each segment is affected differently by technological and regulatory developments. This
report identifies the main factors affecting each segment and forecasts market growth, future trends and product development in every major market segment. Market forecasts are given for the years 2015, 2016 and 2020.

The report is organized by presenting the core segment (sequencing instruments) first, followed by its derivative segments (tools and reagents, data analysis, services). The development of sequencing instruments is vital for RNA-Seq development; thus sequencing instruments segment is classified as the core segment. However, it does
not suggest that the derivative segments are not important. In fact, the RNA-Seq instruments segment is neither the biggest nor the fastest growing among the four segments. The instruments segment, however, provides the infrastructure for the health and growth of the RNA-Seq market as a whole.

Table Of Contents

RNA Sequencing: Technologies and Global Markets
CHAPTER 1 INTRODUCTION 2
STUDY GOALS AND OBJECTIVES 2
REASONS FOR DOING THE STUDY 2
INTENDED AUDIENCE 2
SCOPE AND FORMAT 3
METHODOLOGY AND INFORMATION SOURCES 3
ANALYST'S CREDENTIALS 3
RELATED BCC RESEARCH REPORTS 4
BCC RESEARCH WEBSITE 4
DISCLAIMER 4
CHAPTER 2 SUMMARY 6
SUMMARY TABLE GLOBAL RNA-SEQ MARKET BY SEGMENT, THROUGH 2020 ($
MILLIONS) 8
SUMMARY FIGURE GLOBAL RNA-SEQ MARKET TRENDS BY SEGMENT, 2014-2020 ($
MILLIONS) 8
CHAPTER 3 INTRODUCTION ON RNA-SEQ 10
TRANSCRIPTOMICS 10
TABLE 1 TYPES OF RNAS IN CELLS 10
TABLE 2 TRANSCRIPTOMICS INSIGHTS 10
TECHNOLOGIES FOR TRANSCRIPTOMICS 11
FIGURE 1 COST OF SEQUENCING ONE RAW MEGABASE OF DNA 11
FIGURE 2 COST OF SEQUENCING ONE HUMAN GENOME 12
RNA-SEQ FOR TRANSCRIPTOMICS 13
TABLE 3 COMPARISON OF TRANSCRIPTOMICS METHODS 13
RNA-SEQ EXPERIMENT 14
FIGURE 3 GENERIC RNA-SEQ EXPERIMENT WORKFLOW 14
EXPERIMENTAL DESIGN 14
FIGURE 4 RNA-SEQ EXPERIMENTS FOR TRANSCRIPTOMICS 14
Establish the Primary Experimental Objective 15
TABLE 4 RNA-SEQ ANNOTATION/DGE OPTIONS 15
Replication, Depth and Complexity of the Experiment 17
RNA SAMPLE PREPARATION 17
LIBRARY PREPARATION 18
TABLE 5 FUNCTIONAL ELEMENTS IN SEQUENCING ADAPTERS 19
HIGH-THROUGHPUT SEQUENCING 19
Choosing a Sequencing Platform 20
DATA ANALYSIS 20
CHALLENGES FOR RNA-SEQ 21
LIBRARY CONSTRUCTION CHALLENGES 21
TABLE 6 FRAGMENTATION METHODS AND BIAS 21
BIOINFORMATIC CHALLENGES 22
COST VERSUS COVERAGE CHALLENGES 23
RNA-SEQ INSIGHTS AND APPLICATIONS 23
MAPPING GENE AND EXON BOUNDARIES 23
EXTENSIVE TRANSCRIPT COMPLEXITY 24
NOVEL TRANSCRIPTION 24
DEFINING TRANSCRIPTION LEVEL 24
FUTURE DIRECTION 25
CHAPTER 4 RNA-SEQUENCING INSTRUMENTS 27
OVERVIEW 27
SEQUENCING TECHNOLOGIES FOR RNA-SEQ 27
NOTABLE RNA-SEQ PLATFORMS 28
TABLE 7 ILLUMINA SEQUENCING INSTRUMENTS 28
TABLE 8 THERMO FISHER SEQUENCING INSTRUMENTS 29
TABLE 9 ROCHE SEQUENCING INSTRUMENTS 31
TABLE 10 PACBIO SEQUENCING INSTRUMENTS 32
SEQUENCING PLATFORMS TO WATCH 32
TABLE 11 SIGNIFICANT PLAYERS IN SEQUENCING MARKET 33
TECHNOLOGY AND RNA-SEQ ON ILLUMINA PLATFORMS 33
SBS SEQUENCING TECHNOLOGY 33
Cluster Generation 34
Sequencing by Synthesis 34
SEQUENCING WORKFLOW 34
TABLE 12 WORKFLOW STEPS FOR SEQUENCING SYSTEM 34
RNA-SEQ APPLICATIONS ON ILLUMINA SEQUENCING PLATFORMS 35
TABLE 13 RNA-SEQ APPLICATIONS ON ILLUMINA PLATFORMS 35
mRNA-Seq on Illumina Instruments 35
TABLE 14 MRNA-SEQ ON ILLUMINA PLATFORMS 36
Total RNA-Seq on Illumina Platforms 36
TABLE 15 TOTAL RNA-SEQ ON ILLUMINA PLATFORMS 37
Targeted RNA-Seq 38
TABLE 16 RECOMMENDED SETUP FOR TARGETED RNA-SEQ ON MISEQ PLATFORMS 38
Small RNA Sequencing 38
TABLE 17 SMALL RNA-SEQ ON ILLUMINA PLATFORMS 39
Ribosome Profiling 39
TABLE 18 RIBOSOMAL PROFILING ON ILLUMINA PLATFORMS 40
Ultra-Low-Input and Single-Cell RNA-Seq 40
Low-Quality and FFPE RNA-Seq 41
TECHNOLOGIES AND RNA-SEQ ON THERMO FISHER PLATFORMS 41
SANGER SEQUENCING 41
ION TORRENT TECHNOLOGY 42
Library Construction 42
Template Prep or Amplification 42
Sequencing 43
Data Analysis 43
RNA-SEQ ON ION TORRENT PLATFORMS 43
TABLE 19 RNA-SEQ APPLICATIONS ON ION SYSTEMS 44
SOLID SEQUENCING PLATFORM 44
TABLE 20 SOLID 5500 SEQUENCING PLATFORM PERFORMANCES 45
SOLiD Total RNA-Seq, Small RNA-Seq and miRNA Profiling 45
FIGURE 5 SOLID RNA-SEQ WORKFLOW 45
TECHNOLOGIES AND RNA-SEQ ON PACBIO PLATFORMS 46
SMRT TECHNOLOGY 46
RNA-SEQ APPLICATIONS ON PACBIO PLATFORMS 47
TABLE 21 PACBIO RNA-SEQ APPLICATIONS 47
Human/Plant/Animal RNA-Seq 47
TABLE 22 PACBIO RNA-SEQ WORKFLOW 48
RNA-SEQ APPLICATIONS ON 454 PLATFORMS 48
FIGURE 6 454'S DNA SEQUENCER MECHANISM 48
CDNA RAPID LIBRARY PREP 49
LOW-INPUT RNA SAMPLES 49
TABLE 23 WORKFLOW FOR 454 SEQUENCER 49
OTHER COMMERCIAL SEQUENCING PLATFORMS 50
BGI (COMPLETE GENOMICS) 50
GENEPSYS 50
OXFORD NANOPORE 51
QIAGEN (INTELLIGENT BIOSYSTEMS) 52
NEW SEQUENCING TECHNOLOGIES AND RNA-SEQ APPLICATIONS 52
GENIA 52
BASE4 AND HITACHI 53
GNUBIO/BIO-RAD 53
NABSYS 54
STRATOS GENOMICS 54
TWO PORE GUYS 54
MARKET SHARE OF EACH PLATFORM 54
TABLE 24 HIGH-THROUGHPUT INSTRUMENT COMPETITORS BY INSTALLED
INSTRUMENT BASE, AS OF DECEMBER 2015 (NUMBER/%) 55
TABLE 25 BENCHTOP INSTRUMENT COMPETITORS BY INSTALLED INSTRUMENT
BASE, AS OF DECEMBER 2015 (NUMBER/%) 55
RNA-SEQ INSTRUMENT MARKET PROJECTION 56
TABLE 26 GLOBAL MARKET FOR INSTRUMENTS USED IN DNA SEQUENCING AND
RNA-SEQUENCING, THROUGH 2020 ($ MILLIONS) 56
MARKET TRENDS 56
TABLE 27 REQUIREMENTS FOR RNA-SEQ ON SEQUENCING PLATFORMS 57
CHAPTER 5 RNA-SEQ TOOLS AND REAGENTS 59
OVERVIEW 59
MARKET LANDSCAPE 59
RNA-SEQ AUTOMATION 60
TABLE 28 NOTABLE LIQUID HANDLING PLATFORMS FOR RNA-SEQ AUTOMATION 60
TABLE 29 RNA SAMPLE AND LIBRARY PREPARATION PLATFORMS 60
NEOPREP FROM ILLUMINA 61
REM E SYSTEM FROM ROCHE 61
ION TORRENT ION CHEF SYSTEM FROM THERMO FISHER 61
SOLID EZ BEAD SYSTEM FROM THERMO FISHER 61
C1 SYSTEM FROM FLUIDIGM 61
QIACUBE FROM QIAGEN 61
RNA-SEQ SAMPLE PREPARATION 62
RNA SAMPLE ISOLATION AND PURIFICATION 62
TABLE 30 LEADING PRODUCTS PRESERVING RNA EXPRESSION PROFILE 62
TABLE 31 LEADING COMMERCIAL EXTRACTION OR PURIFICATION KITS 63
RNA CONCENTRATION AND PURITY DETERMINATION 63
TABLE 32 RNA QUANTIFICATION INSTRUMENT 64
RNA SAMPLE QUALITY CONTROL 64
TABLE 33 RNA INTEGRITY MEASURING INSTRUMENT 64
Agilent 2100 Bioanalyzer 65
QIAxcel Advanced System 65
RNA DEPLETION OR ENRICHMENT 65
RRNA DEPLETION 65
TABLE 34 RRNA DELETION KITS 66
RiboMinus Technology from Thermo Fisher 66
NEBNext rRNA Depletion Kit (Human/Mouse/Rat) from NEB 66
GeneRead rRNA Depletion Kits from Qiagen 66
Ribo-Zero rRNA Removal Kit from Illumina 67
RiboGone from Clontech 67
MRNA ENRICHMENT 67
TABLE 35 MRNA ENRICHMENT KITS 67
MagJET mRNA Enrichment Kit from Thermo Fisher 68
Dynabeads from Thermo Fisher 68
Ambion Poly(A)Purist MAG Kit from Thermo Fisher 68
SideStep mRNA Enrichment Kit from Agilent 69
GeneRead Pure mRNA Kit from Qiagen 69
RNA-SEQ LIBRARY PREPARATION 69
RNA-SEQ LIBRARY PREP KITS FROM ILLUMINA 69
TABLE 36 RNA-SEQ KITS FOR ILLUMINA PLATFORM 70
RNA-SEQ LIBRARY PREP PRODUCTS FROM THERMO FISHER 70
TABLE 37 THERMO FISHER RNA-SEQ PRODUCTS FOR ION TORRENT 71
TABLE 38 THERMO FISHER'S RNA-SEQ LIBRARY PREP KITS FOR SOLID 71
RNA-SEQ LIBRARY PREP KITS FROM ROCHE 454 72
TABLE 39 RNA-SEQ LIBRARY PREP KITS FROM 454 72
RNA-SEQ LIBRARY PREP KITS FROM PACBIO PLATFORM 72
TABLE 40 PACBIO'S RNA-SEQ REAGENTS PRODUCTS 72
RNA-SEQ PRODUCTS FROM NEW ENGLAND BIOLABS 73
TABLE 41 RNA-SEQ PRODUCTS FROM NEW ENGLAND BIOLABS 73
RNA-SEQ LIBRARY PREPARATION PRODUCTS FROM KAPA BIOSYSTEMS 74
TABLE 42 RNA-SEQ KITS FROM KAPA BIOSYSTEMS 74
RNA-SEQ PRODUCTS FROM CLONTECH (TAKARA) 74
TABLE 43 RNA-SEQ PRODUCTS FROM CLONTECH 75
RNA-SEQ PRODUCTS FROM AGILENT 75
RNA-SEQ PRODUCTS FROM QIAGEN 75
RNA-SEQ REAGENTS FROM NIMBLEGEN (ROCHE) 75
TABLE 44 RNA-SEQ REAGENTS FROM NIMBLEGEN 75
MARKET ANALYSIS 76
TABLE 45 AVERAGE CONSUMABLE COST OF RUNNING SEQUENCING MACHINES 76
TABLE 46 GLOBAL MARKET FOR DNA-SEQ AND RNA-SEQ CONSUMABLES,
THROUGH 2020 ($ MILLIONS) 77
CHAPTER 6 RNA-SEQ DATA ANALYSIS 79
OVERVIEW 79
FIGURE 7 NEXT-GENERATION SEQUENCING DATA ANALYSIS 79
RNA-SEQ DATA ANALYSIS CHALLENGES 80
DATA SOLUTION 80
ALIGNMENT AND ANNOTATION 80
DATA ANALYSIS FOR LONG-READ SEQUENCERS 80
RNA-SEQ DATA CLOUD SERVICES 80
TABLE 47 CLOUD COMPUTING PROVIDERS FOR GENOMICS/RNA-SEQ 81
STAND-ALONE TOOLS FOR RNA-SEQ DATA ANALYSIS 81
TABLE 48 STAND-ALONE RNA-SEQ DATA ANALYSIS TOOLS 82
RNA-SEQ DATA ANALYSIS ON ILLUMINA PLATFORMS 82
BASESPACE 83
TABLE 49 BASESPACE NOTABLE RNA-SEQ APPS 84
RNA-SEQ DATA ANALYSIS ON OTHER PLATFORMS 85
RNA-SEQ DATA ANALYSIS ON ION TORRENT PLATFORMS 85
RNA-SEQ DATA ANALYSIS ON SOLID PLATFORMS 86
RNA-SEQ DATA ANALYSIS ON 454 PLATFORMS 86
RNA-SEQ DATA ANALYSIS ON PACBIO PLATFORMS 86
RNA-SEQ DATA ANALYSIS MARKET ANALYSIS 86
TABLE 50 GLOBAL MARKET FOR RNA-SEQ DATA ANALYSIS, THROUGH 2020 ($
MILLIONS) 87
CHAPTER 7 RNA-SEQ SERVICE MARKET 89
OVERVIEW 89
PLATFORM-SPECIFIC CERTIFIED SERVICE PROVIDERS 89
ILLUMINA CERTIFIED SERVICE PROVIDERS (CSPRO) 90
TABLE 51 ILLUMINA CERTIFIED SERVICE PROVIDERS (CSPRO) NORTH AMERICA, AS
OF NOVEMBER 2015 91
TABLE 52 ILLUMINA CERTIFIED SERVICE PROVIDERS (CSPRO) EUROPE, AS OF
NOVEMBER 2015 92
TABLE 53 ILLUMINA CERTIFIED SERVICE PROVIDERS (CSPRO) ASIA-PACIFIC, AS OF
NOVEMBER 2015 93
ION TORRENT CERTIFIED SERVICE PROVIDER PROGRAM 94
TABLE 54 ION TORRENT CERTIFIED SERVICE PROVIDERS, AS OF NOVEMBER 2015 94
SOLID NEXT-GENERATION SEQUENCING ANALYSIS SERVICES 96
TABLE 55 SOLID SEQUENCING SERVICE PROVIDERS, AS OF NOVEMBER 2015 96
NIMBLEGEN CERTIFIED SERVICE PROVIDERS ON 454 PLATFORMS 96
TABLE 56 ROCHE SEQUENCING EFFORTS 97
TABLE 57 NIMBLEGEN CERTIFIED SERVICE PROVIDERS 97
PACIFIC BIOSCIENCES (PACBIO) CERTIFIED SERVICE PROVIDERS 98
TABLE 58 PACBIO CERTIFIED SERVICE PROVIDERS, AS OF NOVEMBER 2015 98
TABLE 59 ADDITIONAL SERVICE PROVIDERS ON PACBIO PLATFORMS, AS OF
NOVEMBER 2015 98
AGILENT'S CERTIFIED SERVICE PROVIDERS-TARGET ENRICHMENT 99
TABLE 60 AGILENT CERTIFIED SERVICE PROVIDERS, AS OF NOVEMBER 2015 100
NON-CERTIFIED SERVICE PROVIDERS 100
TABLE 61 NON-CERTIFIED RNA-SEQ PROVIDERS, AS OF NOVEMBER 2015 101
TABLE 62 NON-CERTIFIED, NON-PROFIT SEQUENCING SERVICE PROVIDERS, AS OF
NOVEMBER 2015 101
TABLE 63 NON-CERTIFIED, COMMERCIAL SEQUENCING SERVICE PROVIDERS, AS OF
NOVEMBER 2015 106
NOTABLE SERVICE PROVIDERS 108
TABLE 64 SEQUENCING SERVICE PROVIDERS CERTIFIED BY MULTIPLE PROGRAMS,
AS OF NOVEMBER 2015 108
AMBRY GENETICS 109
BASECLEAR 109
BECKMAN COULTER GENOMICS 109
BGI 109
CEGAT 110
DNA LINK 110
DNAVISION 110
EXIQON A/S 110
EXPRESSION ANALYSIS (Q2 SOLUTIONS) 111
FASTERIS 111
GATC 111
GENEWIZ 111
INTEGRAGEN 111
PERKINELMER INC 112
SEQLL 112
SEQWRIGHT (NOW GE HEALTHCARE) 112
MARKET ANALYSIS 112
TABLE 65 GLOBAL MARKET FOR RNA-SEQ RESEARCH SERVICES, THROUGH 2020 ($
MILLIONS) 113
CHAPTER 8 COMPANY PROFILES 115
AGILENT TECHNOLOGIES INC. 115
AMAZON.COM INC. 115
BGI 116
BIO-RAD 116
DNANEXUS INC. 117
GENERAL ELECTRIC COMPANY 117
ILLUMINA INC. 118
NEW ENGLAND BIOLAB INC. 118
OXFORD NANOPORE TEHNOLOGIES LTD. 119
PACIFIC BIOSCIENCES OF CALIFORNIA INC. 119
QIAGEN NV 120
ROCHE HOLDING AG 120
TAKARA BIO INC. 121
THERMO FISHER SCIENTIFIC INC. 121
CHAPTER 9 COMPANIES MENTIONED IN THE REPORT 123
ACGT INC. 123
ADVANCED GENOMICS 123
AFFILIATED GENETICS INC. 123
AGRESEARCH LIMITED 123
AGYSIS BIOLABS 123
AITBIOTECH 123
ALACRIS 123
ALPHABIOLABS 124
ALTHEA DX 124
AMBRY GENETICS 124
AMPLICON EXPRESS 124
AMRESCO 124
APPLIED BIOLOGICAL MATERIAL INC. 124
AROS APPLIED BIOTECHNOLOGY A/S 124
ARRAYXPRESS INC. 124
ASURAGEN INC. 124
BIORELIANCE 125
CD GENOMICS 125
CEGAT GMBH 125
CENTOGENE AG 125
CHUNLAB INC. 125
CLARITAS GENOMICS 125
CLC BIO 125
CLINICAL GENOMICS 125
CLONTECH LABORATORIES INC. 126
COFACTOR GENOMICS 126
COGENTECH 126
CREATIVE GENOMICS 126
CUROVERSE 126
CYPHER GENOMICS 126
DECODE GENETICS 126
DELTAGENE MOLECULAR DIAGNOSTIC 126
DENA LIFE SCIENCE INC. 126
DNA ANALYSIS LLC. 127
DNA LINK INC. 127
DNANEXUS 127
DNAVISION 127
EAGLE GENOMICS 127
EDGEBIO 127
ELIM BIOPHARMACEUTICALS 127
ENSIGNA BIOSYSTEMS INC. 127
EPICENTRE 128
EPOCH LIFE SCIENCE 128
EPPENDORF 128
ERA7 BIOINFORMATICS 128
EUREKA GENOMICS 128
EUROFINS MWG OPERON 128
EXIQON 128
EXPRESSION ANALYSIS 128
FASTERIS SA 129
FAVORGEN BIOTECH COMPANY 129
FIRST BASE LABORATORIES 129
FLUIDIGM 129
FUNCTIONAL BIOSCIENCES 129
GATC BIOTECH AG 129
GE HEALTHCARE 129
GENAPSYS 130
GENE DX 130
GENEAID BIOTECH 130
GENEBLITZ 130
GENECHRON 130
GENERGY BIOTECHNOLOGY 130
GENES DIFFUSION 130
GENESEEK 130
GENESTACK 130
GENETIC VISIONS INC. 131
GENETICLAB CO. LTD. 131
GENEWIZ INC. 131
GENIA TECHNOLOGIES 131
GENOMA 131
GOOGLE GENOME CLOUD 131
GENOME INTERNATIONAL CORP. 131
GENOMED 132
GENOSPACE 132
GENOTECH CORP. 132
GEOSPIZA 132
GIRIHLET INC. 132
GLOBUS GENOMICS 132
GNUBIO 132
HAMILTON ROBOTICS 133
HOKKAIDO SYSTEM SCIENCE CO., LTD 133
IGA TECHNOLOGY SERVICES SRL 133
ILLUMINA 133
IMGM LABORATORIES GMBH 133
INGENUITY 133
INQABA BIOTEC 133
INTEGRAGEN 133
INTELLIGENT BIO-SYSTEM 134
KAPA BIOSYSTEMS 134
KEYGENE 134
LAB FELLOWS INC. 134
LABCORP CLINICAL TRIALS 134
LARAGEN 134
LC SCIENCES 134
LGC GENOMICS 134
LI-COR BIOSCIENCES 135
LIFESEQUENCING SL 135
LOFSTRAND LABS 135
LONE STAR LABS INC. 135
LUCIGEN CORP. 135
MACROGEN 135
MCLAB 135
MICROSYNTH AG 135
MOGENE, LC 136
NABSYS 136
NEW ENGLAND BIOLABS 136
NIMBLEGEN 136
NIMGENETICS 136
NORGEN BIOTEK CORP 136
OMEGA BIOSERVICES 136
OMICIA 136
ONECODEX 137
OTOGENETICS CORP. 137
OXFORD NANOPORE TECHNOLOGIES 137
PACIFIC BIOSCIENCES 137
PARTEK 137
PERSONALIS 137
PROMEGA 137
QIAGEN 137
RETROGEN 138
RIKENGENESIS CO. LTD. 138
RNASSIST 138
ROCHE SEQUENCING 138
SELAH GENOMICS 138
SEQLL INC. 138
SEQMATIC 138
SEQUENCEBASE 138
SEQUENSYS 139
SEQUETECH 139
SEQUISERVE 139
SEQXCEL 139
SERVICEXS B.V. 139
SEVEN BRIDGES GENOMICS 139
SHIMADZU 139
SIGMA-ALDRICH 139
SINOGENOMAX CO. LTD. 140
SISTEMAS GENOMICOS 140
SNP GENETICS INC. 140
SOLVEBIO 140
SOLVIAS 140
SORENSON GENOMICS 140
SOURCE BIOSCIENCE 140
SPIRAL GENETICS 140
STARSEQ 141
STRAND NGS 141
STRATOS GENOMICS 141
SYAPSE 141
SYNERGENE BIOTECH GMBH 141
SYNTHETIC GENOMICS 141
SYSTEM BIOSCIENCES 141
TAKARA BIO INC. 141
TAUERET LABORATORIES 142
TECAN 142
TEPNEL PHARMACEUTICAL SERVICES 142
THERMO FISHER SCIENTIFIC 142
TRAITGENETICSGMBH 142
TUTE GENOMICS 142
TWO PORE GUYS 142
VBC-BIOTECH 142
VIA GENETICS 143
WAFERGEN 143
WUXI APPTEC 143
WUXI NEXTCODE 143
YORKSHIRE BIOSCIENCE 143
YOURGENE BIOSCIENCE 143
ZOETIS GENETICS 143
ZS GENETICS 144
ZYMO RESEARCH 144

LIST OF TABLES

SUMMARY TABLE GLOBAL RNA-SEQ MARKET BY SEGMENT, THROUGH 2020 ($
MILLIONS) 8
TABLE 1 TYPES OF RNAS IN CELLS 10
TABLE 2 TRANSCRIPTOMICS INSIGHTS 10
TABLE 3 COMPARISON OF TRANSCRIPTOMICS METHODS 13
TABLE 4 RNA-SEQ ANNOTATION/DGE OPTIONS 15
TABLE 5 FUNCTIONAL ELEMENTS IN SEQUENCING ADAPTERS 19
TABLE 6 FRAGMENTATION METHODS AND BIAS 21
TABLE 7 ILLUMINA SEQUENCING INSTRUMENTS 28
TABLE 8 THERMO FISHER SEQUENCING INSTRUMENTS 29
TABLE 9 ROCHE SEQUENCING INSTRUMENTS 31
TABLE 10 PACBIO SEQUENCING INSTRUMENTS 32
TABLE 11 SIGNIFICANT PLAYERS IN SEQUENCING MARKET 33
TABLE 12 WORKFLOW STEPS FOR SEQUENCING SYSTEM 34
TABLE 13 RNA-SEQ APPLICATIONS ON ILLUMINA PLATFORMS 35
TABLE 14 MRNA-SEQ ON ILLUMINA PLATFORMS 36
TABLE 15 TOTAL RNA-SEQ ON ILLUMINA PLATFORMS 37
TABLE 16 RECOMMENDED SETUP FOR TARGETED RNA-SEQ ON MISEQ PLATFORMS 38
TABLE 17 SMALL RNA-SEQ ON ILLUMINA PLATFORMS 39
TABLE 18 RIBOSOMAL PROFILING ON ILLUMINA PLATFORMS 40
TABLE 19 RNA-SEQ APPLICATIONS ON ION SYSTEMS 44
TABLE 20 SOLID 5500 SEQUENCING PLATFORM PERFORMANCES 45
TABLE 21 PACBIO RNA-SEQ APPLICATIONS 47
TABLE 22 PACBIO RNA-SEQ WORKFLOW 48
TABLE 23 WORKFLOW FOR 454 SEQUENCER 49
TABLE 24 HIGH-THROUGHPUT INSTRUMENT COMPETITORS BY INSTALLED
INSTRUMENT BASE, AS OF DECEMBER 2015 (NUMBER/%) 55
TABLE 25 BENCHTOP INSTRUMENT COMPETITORS BY INSTALLED INSTRUMENT BASE,
AS OF DECEMBER 2015 (NUMBER/%) 55
TABLE 26 GLOBAL MARKET FOR INSTRUMENTS USED IN DNA SEQUENCING AND
RNA-SEQUENCING, THROUGH 2020 ($ MILLIONS) 56
TABLE 27 REQUIREMENTS FOR RNA-SEQ ON SEQUENCING PLATFORMS 57
TABLE 28 NOTABLE LIQUID HANDLING PLATFORMS FOR RNA-SEQ AUTOMATION 60
TABLE 29 RNA SAMPLE AND LIBRARY PREPARATION PLATFORMS 60
TABLE 30 LEADING PRODUCTS PRESERVING RNA EXPRESSION PROFILE 62
TABLE 31 LEADING COMMERCIAL EXTRACTION OR PURIFICATION KITS 63
TABLE 32 RNA QUANTIFICATION INSTRUMENT 64
TABLE 33 RNA INTEGRITY MEASURING INSTRUMENT 64
TABLE 34 RRNA DELETION KITS 66
TABLE 35 MRNA ENRICHMENT KITS 67
TABLE 36 RNA-SEQ KITS FOR ILLUMINA PLATFORM 70
TABLE 37 THERMO FISHER RNA-SEQ PRODUCTS FOR ION TORRENT 71
TABLE 38 THERMO FISHER'S RNA-SEQ LIBRARY PREP KITS FOR SOLID 71
TABLE 39 RNA-SEQ LIBRARY PREP KITS FROM 454 72
TABLE 40 PACBIO'S RNA-SEQ REAGENTS PRODUCTS 72
TABLE 41 RNA-SEQ PRODUCTS FROM NEW ENGLAND BIOLABS 73
TABLE 42 RNA-SEQ KITS FROM KAPA BIOSYSTEMS 74
TABLE 43 RNA-SEQ PRODUCTS FROM CLONTECH 75
TABLE 44 RNA-SEQ REAGENTS FROM NIMBLEGEN 75
TABLE 45 AVERAGE CONSUMABLE COST OF RUNNING SEQUENCING MACHINES 76
TABLE 46 GLOBAL MARKET FOR DNA-SEQ AND RNA-SEQ CONSUMABLES, THROUGH
2020 ($ MILLIONS) 77
TABLE 47 CLOUD COMPUTING PROVIDERS FOR GENOMICS/RNA-SEQ 81
TABLE 48 STAND-ALONE RNA-SEQ DATA ANALYSIS TOOLS 82
TABLE 49 BASESPACE NOTABLE RNA-SEQ APPS 84
TABLE 50 GLOBAL MARKET FOR RNA-SEQ DATA ANALYSIS, THROUGH 2020 ($
MILLIONS) 87
TABLE 51 ILLUMINA CERTIFIED SERVICE PROVIDERS (CSPRO) NORTH AMERICA, AS
OF NOVEMBER 2015 91
TABLE 52 ILLUMINA CERTIFIED SERVICE PROVIDERS (CSPRO) EUROPE, AS OF
NOVEMBER 2015 92
TABLE 53 ILLUMINA CERTIFIED SERVICE PROVIDERS (CSPRO) ASIA-PACIFIC, AS OF
NOVEMBER 2015 93
TABLE 54 ION TORRENT CERTIFIED SERVICE PROVIDERS, AS OF NOVEMBER 2015 94
TABLE 55 SOLID SEQUENCING SERVICE PROVIDERS, AS OF NOVEMBER 2015 96
TABLE 56 ROCHE SEQUENCING EFFORTS 97
TABLE 57 NIMBLEGEN CERTIFIED SERVICE PROVIDERS 97
TABLE 58 PACBIO CERTIFIED SERVICE PROVIDERS, AS OF NOVEMBER 2015 98
TABLE 59 ADDITIONAL SERVICE PROVIDERS ON PACBIO PLATFORMS, AS OF
NOVEMBER 2015 98
TABLE 60 AGILENT CERTIFIED SERVICE PROVIDERS, AS OF NOVEMBER 2015 100
TABLE 61 NON-CERTIFIED RNA-SEQ PROVIDERS, AS OF NOVEMBER 2015 101
TABLE 62 NON-CERTIFIED, NON-PROFIT SEQUENCING SERVICE PROVIDERS, AS OF
NOVEMBER 2015 101
TABLE 63 NON-CERTIFIED, COMMERCIAL SEQUENCING SERVICE PROVIDERS, AS OF
NOVEMBER 2015 106
TABLE 64 SEQUENCING SERVICE PROVIDERS CERTIFIED BY MULTIPLE PROGRAMS,
AS OF NOVEMBER 2015 108
TABLE 65 GLOBAL MARKET FOR RNA-SEQ RESEARCH SERVICES, THROUGH 2020 ($
MILLIONS) 113

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    Japan  

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Genome Sequencing Industry in the UK

  • November 2016
    29 pages
  • Genome Sequenci...  

    Infectious Dise...  

  • United Kingdom  

    United States  

View report >

Related Market Segments :

Genome Sequencing

ref:plp2016

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