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Genome Editing: Technologies and Global Markets

  • March 2016
  • -
  • BCC Research
  • -
  • 129 pages

This BCC Research report provides detailed market and industry analyses of the rapidly growing global market for genome editing. Important trends of the field and market segments are identified, and market sizes and sales forecasts by segmented markets are provided through 2020.

Use this report to:

Gain insight into the genome editing market, along with a comprehensive review of genome editing technologies with related latest progresses in the field.
Gain a clear understanding about the global market for genome editing by region, industry, application, product and type, technology, and end-user.
Assess information about companies and their corporate profiles, and the most relevant patents.

Highlights

The global market for genome editing totaled $206.0 million in 2014 and $395.0 million in 2015. The market should total over $2.0 billion by 2020, growing at a compound annual growth rate (CAGR) of 38.9% from 2015 to 2020.
The U.S. market for genome editing totaled $151.0 million in 2015, and should total $806.0 million by 2020, growing at a CAGR of 39.8% from 2015 to 2020.
The genome editing market in European totaled $116.0 million in 2015 and should total $568.0 million by 2020 at a CAGR of 37.4% from 2015 to 2020.

INTRODUCTION

In today’s life science industry, genome editing’s popularity is rising. Genome editing is a type of genetic engineering technologies where DNA is inserted, replaced or removed from a genome by using artificially engineered nucleases. Genome editing is a logical next step to the next-generation sequencing technologies and functional genomics studies in understanding and manipulating genes. The technologies and related
applications for precise genome editing have exploded in growth in the past two years.

Despite ethical issues debates, precisely manipulating genes is a major life science tool to understand and manipulate related genes in the treatment of a variety of genetic diseases.

STUDY GOALS AND OBJECTIVES

This report provides detailed market and industry analyses to help readers quantify and qualify the rapidly growing global market for genome editing. Important trends of the field and market segments are identified, and market sizes and sales forecasts by segmented markets are provided through 2020.

This report emphasizes the market side rather than the technical side. The detailed market segmentation, market shares, major drivers, trend analysis and forecasts for the entire genome editing market are analyzed. Particularly, this report mainly includes:

An overview of the global genome editing industry, including its technologies, applications and markets.

Analysis of global market trends, with data from 2014, estimates for 2015, and projections of compound annual growth rates (CAGRs) through 2020.

Breakdowns of the market by region, product type, application and technology.

A focus on the market size and segmentation of genome editing products, including genome editing tools, cell lines, animal models and potential clinical products.

A look at the recent technical breakthrough on the use of clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9, and how it has fueled the rapid growth of the genome editing industry.
A look at the growth driving factors and the factors that may limit the market’s growth.

A look at the major technical issues to overcome before genome editing is used in clinic applications.

Current status on the intellectual property right of the CRISPR-Cas9 genome editing technology.

Discussion of the ethical and regulatory issues, as well as patent analysis, publication analysis and research funding in this area.

Analysis of the competitive landscape and opportunities.

Comprehensive company profiles of the major players in the current genome editing field.



Table Of Contents

Genome Editing: Technologies and Global Markets

CHAPTER 1 INTRODUCTION 2
STUDY GOALS AND OBJECTIVES 2
REASONS FOR DOING THIS STUDY 3
INTENDED AUDIENCE 3
SCOPE OF REPORT 3
METHODOLOGY 4
INFORMATION SOURCES 4
ANALYST'S CREDENTIALS 4
RELATED BCC RESEARCH REPORTS 5
BCC RESEARCH WEBSITE 5
DISCLAIMER 5
CHAPTER 2 MARKET SUMMARY 7
KEY DRIVERS FOR MARKET GROWTH 7
SUMMARY TABLE GLOBAL GENOME EDITING MARKET BY REGION, THROUGH 2020
($ MILLIONS) 8
SUMMARY FIGURE GLOBAL GENOME EDITING MARKET BY REGION, 2014-2020 ($
MILLIONS) 8
CHAPTER 3 CURRENT GENOME EDITING TECHNOLOGIES 10
OVERVIEW 10
HISTORY OF GENOME EDITING 10
COMPARISON OF GENOME EDITORS 11
DISCOVERY OF CRISPR/CAS9 12
COMPONENTS OF CRISPR/CAS SYSTEMS 13
SGRNA 14
CAS9 NUCLEASES 14
HOW CRISPR/CAS WORKS 14
ADVANTAGES OF THE CRISPR/CAS9 SYSTEM 16
POPULARITY OF CRISPR GENOME EDITING 16
MAJOR TECHNOLOGICAL ISSUES 17
EFFICIENCY 17
SPECIFICITY/OFF-TARGET EFFECT 18
DELIVERY SYSTEMS 20
Viral Delivery Systems 20
Non-Viral Delivery Systems 21
Physical Delivery Systems 21
A NEW GENOME EDITING SYSTEM: CRISPR-CPF1 22
STUDIES ON TREATING DISEASES USING GENOME EDITING 23
IMPACTS OF GENOME EDITING 24
FUTURE OF CRISPR 25
CHAPTER 4 APPLICATIONS OF GENOME EDITING 27
INTRODUCTION 27
ACADEMIC RESEARCH 27
DRUG DISCOVERY AND DEVELOPMENT 30
CLINICAL THERAPY 33
NON-TRANSGENIC BREEDING 35
OTHER APPLICATIONS 37
CHAPTER 5 MARKET SEGMENTATION AND FORECAST 39
MARKET OVERVIEW 39
MAJOR PLAYERS 39
TABLE 1 MAJOR COMPANIES THAT HAVE BUSINESS RELATED TO GENOME EDITING 40
TABLE 2 DISTRIBUTION OF COMPANIES THAT HAVE GENOME EDITING RELATED
BUSINESSES BY REGION, AS OF JANUARY 2016 41
FIGURE 1 DISTRIBUTION OF COMPANIES THAT HAVE GENOME EDITING RELATED
BUSINESSES BY REGION, AS OF JANUARY 2016 (%) 41
TABLE 3 DISTRIBUTION OF COMPANIES THAT HAVE GENOME EDITING RELATED
BUSINESSES BY STATE IN THE U.S., AS OF JANUARY 2016 (NUMBER/%) 42
MARKET SEGMENTS BY REGION 42
TABLE 4 GLOBAL MARKET FOR GENOME EDITING BY REGION, THROUGH 2020 ($
MILLIONS) 43
FIGURE 2 GLOBAL MARKET FOR GENOME EDITING BY REGION, 2014-2020 ($
MILLIONS) 43
FIGURE 3 GLOBAL GENOME EDITING MARKET SHARE BY REGION, 2014 (%) 43
FIGURE 4 GLOBAL GENOME EDITING MARKET SHARE BY REGION, 2020 (%) 44
MARKET SEGMENTS BY APPLICATION 45
TABLE 5 GLOBAL MARKETS FOR GENOME EDITING BY APPLICATION, THROUGH
2020 ($ MILLIONS) 46
FIGURE 5 GLOBAL MARKET SHARES FOR GENOME EDITING BY APPLICATION, 2014
(%) 46
FIGURE 6 GLOBAL MARKET SHARES FOR GENOME EDITING BY APPLICATION, 2020
(%) 46
TABLE 6 U.S. MARKET FOR GENOME EDITING BY APPLICATION, THROUGH 2020 ($
MILLIONS) 48
FIGURE 7 U.S. MARKET SHARES FOR GENOME EDITING BY APPLICATION, 2014 (%) 48
FIGURE 8 U.S. MARKET SHARES FOR GENOME EDITING BY APPLICATION, 2020 (%) 49
TABLE 7 EUROPEAN MARKET FOR GENOME EDITING BY APPLICATION, THROUGH
2020 ($ MILLIONS) 50
FIGURE 9 EUROPEAN MARKET SHARES FOR GENOME EDITING BY APPLICATION,
2014 (%) 50
FIGURE 10 EUROPEAN MARKET SHARES FOR GENOME EDITING BY APPLICATION,
2020 (%) 50
TABLE 8 ASIA-PACIFIC MARKET FOR GENOME EDITING BY APPLICATION, THROUGH
2020 ($ MILLIONS) 52
FIGURE 11 ASIA-PACIFIC MARKET SHARES FOR GENOME EDITING BY APPLICATION,
2014 (%) 52
FIGURE 12 ASIA-PACIFIC MARKET SHARES FOR GENOME EDITING BY APPLICATION,
2020 (%) 52
TABLE 9 REST OF WORLD MARKET FOR GENOME EDITING BY APPLICATION,
THROUGH 2020 ($ MILLIONS) 54
MARKET SEGMENTS BY TECHNOLOGY 54
TABLE 10 GLOBAL MARKET FOR GENOME EDITING BY TECHNOLOGY, THROUGH
2020 ($ MILLIONS) 55
FIGURE 13 GLOBAL MARKET SHARES FOR GENOME EDITING BY TECHNOLOGY,
2014 (%) 55
FIGURE 14 GLOBAL MARKET SHARES FOR GENOME EDITING BY TECHNOLOGY,
2020 (%) 55
TABLE 11 U.S. MARKET FOR GENOME EDITING BY TECHNOLOGY, THROUGH 2020
($ MILLIONS) 57
FIGURE 15 U.S. MARKET SHARES FOR GENOME EDITING BY TECHNOLOGY, 2014 (%) 57
FIGURE 16 U.S. MARKET SHARES FOR GENOME EDITING BY TECHNOLOGY, 2020 (%) 57
TABLE 12 EUROPEAN MARKET FOR GENOME EDITING BY TECHNOLOGY, THROUGH
2020 ($ MILLIONS) 59
FIGURE 17 EUROPEAN MARKET SHARES FOR GENOME EDITING BY TECHNOLOGY,
2014 (%) 59
FIGURE 18 EUROPEAN MARKET SHARES FOR GENOME EDITING BY TECHNOLOGY,
2020 (%) 59
TABLE 13 ASIA-PACIFIC MARKET FOR GENOME EDITING BY TECHNOLOGY,
THROUGH 2020 ($ MILLIONS) 61
FIGURE 19 ASIA-PACIFIC MARKET SHARES FOR GENOME EDITING BY TECHNOLOGY,
2014 (%) 61
FIGURE 20 ASIA-PACIFIC MARKET SHARES FOR GENOME EDITING BY TECHNOLOGY,
2020 (%) 61
TABLE 14 REST OF WORLD MARKET FOR GENOME EDITING BY TECHNOLOGY,
THROUGH 2020 ($ MILLIONS) 62
MARKET SEGMENTS BY PRODUCT TYPE 63
TABLE 15 GLOBAL MARKET FOR GENOME EDITING BY PRODUCT TYPE, THROUGH
2020 ($ MILLIONS) 63
FIGURE 21 GLOBAL MARKET SHARES FOR GENOME EDITING BY PRODUCT TYPE,
2014 (%) 64
FIGURE 22 GLOBAL MARKET SHARES FOR GENOME EDITING BY PRODUCT TYPE,
2020 (%) 64
TABLE 16 U.S. MARKET FOR GENOME EDITING BY PRODUCT TYPE, THROUGH 2020
($ MILLIONS) 66
TABLE 17 EUROPEAN MARKET FOR GENOME EDITING BY PRODUCT TYPE,
THROUGH 2020 ($ MILLIONS) 66
TABLE 18 ASIA-PACIFIC MARKET FOR GENOME EDITING BY PRODUCT TYPE,
THROUGH 2020 ($ MILLIONS) 67
TABLE 19 REST OF WORLD MARKET FOR GENOME EDITING BY PRODUCT TYPE,
THROUGH 2020 ($ MILLIONS) 67
CHAPTER 6 CONTRACT SERVICES MARKET ANALYSIS 69
MARKET OVERVIEW 69
MAJOR PLAYERS 69
TABLE 20 MAJOR COMPANIES THAT PROVIDE GENOME EDITING RELATED SERVICES,
AS OF JANUARY 31, 2016 69
MARKET SHARE AND PROJECTION 70
TABLE 21 GLOBAL MARKET FOR GENOME EDITING SERVICES BY REGION,
THROUGH 2020 ($ MILLIONS) 70
FIGURE 23 GLOBAL MARKET SHARES FOR GENOME EDITING SERVICES BY REGION,
2014 (%) 70
FIGURE 24 GLOBAL MARKET SHARES FOR GENOME EDITING SERVICES BY REGION,
2020 (%) 71
COMPARISON WITH PRODUCT SEGMENT 72
TABLE 22 GLOBAL MARKET FOR GENOME EDITING BY PRODUCT AND SERVICE,
THROUGH 2020 ($ MILLIONS) 72
FIGURE 25 GLOBAL MARKET SHARES FOR GENOME EDITING BY PRODUCT AND
SERVICE, 2014 (%) 73
FIGURE 26 GLOBAL MARKET SHARES FOR GENOME EDITING BY PRODUCT AND
SERVICE, 2020 (%) 73
TABLE 23 U.S. MARKET FOR GENOME EDITING BY PRODUCT AND SERVICE,
THROUGH 2020 ($ MILLIONS) 74
TABLE 24 EUROPEAN MARKET FOR GENOME EDITING BY PRODUCT AND SERVICE,
THROUGH 2020 ($ MILLIONS) 74
TABLE 25 ASIA-PACIFIC MARKET FOR GENOME EDITING BY PRODUCT AND SERVICE,
THROUGH 2020 ($ MILLIONS) 75
TABLE 26 REST OF WORLD MARKET FOR GENOME EDITING BY PRODUCT AND
SERVICE, THROUGH 2020 ($ MILLIONS) 75
CHAPTER 7 RESEARCH MARKET ANALYSIS 77
MARKET OVERVIEW 77
MARKER SHARE AND PROJECTIONS 77
TABLE 27 GLOBAL ACADEMIC RESEARCH MARKET FOR GENOME EDITING BY
REGION, THROUGH 2020 ($ MILLIONS) 78
FIGURE 27 GLOBAL ACADEMIC RESEARCH MARKET SHARES FOR GENOME EDITING
BY REGION, 2014 (%) 78
FIGURE 28 GLOBAL ACADEMIC RESEARCH MARKET SHARES FOR GENOME EDITING
BY REGION, 2020 (%) 79
PATENT ANALYSIS 79
TABLE 28 DISTRIBUTION OF GENOME EDITING PATENTS AND PATENT
APPLICATIONS AT USPTO BY COUNTRY (NUMBER/%) 80
TABLE 29 DISTRIBUTION OF U.S. GENOME EDITING PATENTS AND PATENT
APPLICATIONS AT WIPO BY STATE (NUMBER/%) 80
TABLE 30 DISTRIBUTION OF GENOME EDITING PATENTS AND PATENT
APPLICATIONS AT WIPO BY PATENT OFFICE (NUMBER/%) 81
TABLE 31 GENOME EDITING PATENTS AND PATENT APPLICATIONS AT USPTO BY
YEAR, 2007-2015 81
TABLE 32 GENOME EDITING PATENTS AND PATENT APPLICATIONS AT WIPO BY
YEAR, 2007-2015 82
TABLE 33 GENOME EDITING PATENTS AND PATENT APPLICATIONS AT USPTO BY
TECHNOLOGY, 2007-2015 (NUMBER/%) 82
FIGURE 29 GENOME EDITING PATENTS AND PATENT APPLICATIONS BY
TECHNOLOGY, 2007-2015 (%) 82
PUBLICATION ANALYSIS 83
FIGURE 30 NUMBER OF CRISPR PUBLICATIONS BY YEAR, 2005-2015 84
FIGURE 31 NUMBER OF ZFNS PUBLICATIONS BY YEAR, 2005-2015 84
FIGURE 32 NUMBER OF TALENS PUBLICATIONS BY YEAR, 2011-2015 84
RESEARCH FUNDING ANALYSIS 85
TABLE 34 NIH FUNDING FOR GENE/GENOME EDITING BY YEAR, 2007-2015 ($
MILLIONS) 85
FIGURE 33 NIH FUNDING FOR GENE/GENOME EDITING BY YEAR, 2007-2015 ($
MILLIONS) 85
TABLE 35 NIH-FUNDED RESEARCH GRANTS BY YEAR, 2007-2015 (NUMBER OF
GRANTS) 86
FIGURE 34 NIH-FUNDED RESEARCH GRANTS BY YEAR, 2007-2015 (NUMBER OF
GRANTS) 86
CHAPTER 8 DRUG DEVELOPMENT MARKET ANALYSIS 88
MARKET OVERVIEW 88
MARKET SHARE AND FORECAST 88
TABLE 36 GLOBAL DRUG DEVELOPMENT MARKET FOR GENOME EDITING BY
REGION, THROUGH 2020 ($ MILLIONS) 89
FIGURE 35 GLOBAL DRUG DEVELOPMENT MARKET FOR GENOME EDITING BY
REGION, 2014 (%) 89
FIGURE 36 GLOBAL DRUG DEVELOPMENT MARKET FOR GENOME EDITING BY
REGION, 2020 (%) 90
CHAPTER 9 AGRICULTURAL BIOTECHNOLOGY MARKET ANALYSIS 93
MARKET OVERVIEW 93
MARKET SHARE AND FORECAST 93
TABLE 37 GLOBAL PLANT BREEDING MARKET FOR GENOME EDITING BY REGION,
THROUGH 2020 ($ MILLIONS) 94
FIGURE 37 GLOBAL PLANT BREEDING MARKET FOR GENOME EDITING BY REGION,
2014 (%) 94
FIGURE 38 GLOBAL PLANT BREEDING MARKET FOR GENOME EDITING BY REGION,
2020 (%) 95
CHAPTER 10 CLINICAL MARKET ANALYSIS 97
MARKET OVERVIEW 97
MARKET SHARE AND FORECAST 97
FIGURE 39 GLOBAL CLINIC GENOME EDITING MARKET BY REGION, 2020 (%) 97
COMPARISON WITH NON-CLINICAL MARKET 98
TABLE 38 GLOBAL MARKET FOR GENOME EDITING BY CLINICAL PRODUCT AND
NON-CLINICAL PRODUCT, THROUGH 2020 ($ MILLIONS) 99
FIGURE 40 GLOBAL MARKET FOR GENOME EDITING BY CLINICAL PRODUCT AND
NON-CLINICAL PRODUCT, 2020 (%) 99
TABLE 39 U.S. MARKET FOR GENOME EDITING BY CLINICAL PRODUCT AND
NON-CLINICAL PRODUCT, THROUGH 2020 ($ MILLIONS) 99
TABLE 40 EUROPEAN MARKET FOR GENOME EDITING BY CLINICAL PRODUCT AND
NON-CLINICAL PRODUCT, THROUGH 2020 ($ MILLIONS) 100
TABLE 41 ASIA-PACIFIC MARKET FOR GENOME EDITING BY CLINICAL PRODUCT
AND NON-CLINICAL PRODUCT, THROUGH 2020 ($ MILLIONS) 101
TABLE 42 REST OF WORLD MARKET FOR GENOME EDITING BY CLINICAL PRODUCT
AND NON-CLINICAL PRODUCT, THROUGH 2020 ($ MILLIONS) 101
CHAPTER 11 COMPETITION LANDSCAPE AND OPPORTUNITIES 103
OVERVIEW 103
GROWTH STRATEGIES 103
LICENSING AND AGREEMENTS 103
COLLABORATIONS WITH BIG BIOPHARMACEUTICAL COMPANIES 104
IN-HOUSE RandD PROGRAM 105
STARTUP 105
STRATEGIC ALLIANCE AND JOINT VENTURE 105
FOCUS ON SPECIFIC APPLICATION AREAS 106
VENTURE CAPITAL FUNDING 107
OPPORTUNITIES 108
CHAPTER 12 FACTORS INFLUENCING THE GENOME EDITING MARKET 110
INTRODUCTION 110
DRIVING FORCES 110
NEW GENOME EDITING TECHNOLOGIES AND RELATED ADVANCEMENTS 110
NEW APPLICATIONS OF GENOME EDITING 110
NEED OF PRECISION MEDICINE 111
NEED OF IMPROVING DRUG DISCOVERY PROCESS 111
INCREASING DEMAND FOR SYNTHETIC GENES IN SYNTHETIC BIOLOGY 111
INVESTMENTS FROM BOTH PUBLIC AND PRIVATE SECTORS 111
INCREASED RandD EXPENDITURES IN RELATED INDUSTRIAL SECTORS 112
HIGH PREVALENCE OF GENETIC BIRTH DISORDERS 112
CONCERNS ON GENETICALLY MODIFIED CROPS 112
FACTORS LIMITING THE MARKET'S GROWTH 112
STRINGENT REGULATORY FRAMEWORKS AND TIME-CONSUMING
APPROVAL PROCESSES 112
RESEARCH FUNDING 113
PATENT DISPUTE 113
GOVERNMENTAL POLICIES AND REGULATIONS 114
REGULATORY UNCERTAINTY ON GENOME EDITED CROPS 115
ETHICAL ISSUE 115
CHAPTER 13 COMPANY PROFILES 119
ADDGENE 119
AGILENT TECHNOLOGIES INC. 119
APPLIED STEMCELL INC. 120
ASTRA ZENECA 120
CALYXT 121
CARIBOU BIOSCIENCES 121
CELLECTA INC. 122
CELLECTIS S.A. 123
CIBUS 124
CLONTECH LABORATORIES 124
CRISPR THERAPEUTICS 125
DESKTOP GENETICS 125
DNA2.0 126
EDITAS MEDICINE 127
GE HEALTHCARE DHARMACON 127
GENECOPOEIA 128
GENSCRIPT 129
HORIZON DISCOVERY 129
INNOVATIVE GENOMICS INITIATIVE 131
INTELLIA THERAPEUTICS INC. 131
INTEGRATED DNA TECHNOLOGIES 132
IXCELLS BIOTECHNOLOGIES 132
JUNO THERAPEUTICS 133
LONZA 133
NEW ENGLAND BIOLABS 134
NOVA SYNTHETIX 134
ORIGENE TECHNOLOGIES 135
PRECISION BIOSCIENCES INC. 135
RECOMBINETICS 136
REGENERON PHARMACEUTALS INC. 137
SANGAMO BIOSCIENCES 137
SIGMA-ALDRICH CORP. 138
SYSTEM BIOSCIENCES 139
THERMO FISHER SCIENTIFIC 139
TOOLGEN INC. 139
TRANS GENIC INC. 140
TRANSOMIC TECHNOLOGIES INC. 141
TRANSPOSAGEN BIOPHARMACEUTICALS INC. 141

LIST OF TABLES

SUMMARY TABLE GLOBAL GENOME EDITING MARKET BY REGION, THROUGH 2020 ($
MILLIONS) 8
TABLE 1 MAJOR COMPANIES THAT HAVE BUSINESS RELATED TO GENOME EDITING 40
TABLE 2 DISTRIBUTION OF COMPANIES THAT HAVE GENOME EDITING RELATED
BUSINESSES BY REGION, AS OF JANUARY 2016 41
TABLE 3 DISTRIBUTION OF COMPANIES THAT HAVE GENOME EDITING RELATED
BUSINESSES BY STATE IN THE U.S., AS OF JANUARY 2016 (NUMBER/%) 42
TABLE 4 GLOBAL MARKET FOR GENOME EDITING BY REGION, THROUGH 2020 ($
MILLIONS) 43
TABLE 5 GLOBAL MARKETS FOR GENOME EDITING BY APPLICATION, THROUGH 2020
($ MILLIONS) 46
TABLE 6 U.S. MARKET FOR GENOME EDITING BY APPLICATION, THROUGH 2020 ($
MILLIONS) 48
TABLE 7 EUROPEAN MARKET FOR GENOME EDITING BY APPLICATION, THROUGH
2020 ($ MILLIONS) 50
TABLE 8 ASIA-PACIFIC MARKET FOR GENOME EDITING BY APPLICATION, THROUGH
2020 ($ MILLIONS) 52
TABLE 9 REST OF WORLD MARKET FOR GENOME EDITING BY APPLICATION,
THROUGH 2020 ($ MILLIONS) 54
TABLE 10 GLOBAL MARKET FOR GENOME EDITING BY TECHNOLOGY, THROUGH
2020 ($ MILLIONS) 55
TABLE 11 U.S. MARKET FOR GENOME EDITING BY TECHNOLOGY, THROUGH 2020 ($
MILLIONS) 57
TABLE 12 EUROPEAN MARKET FOR GENOME EDITING BY TECHNOLOGY, THROUGH
2020 ($ MILLIONS) 59
TABLE 13 ASIA-PACIFIC MARKET FOR GENOME EDITING BY TECHNOLOGY, THROUGH
2020 ($ MILLIONS) 61
TABLE 14 REST OF WORLD MARKET FOR GENOME EDITING BY TECHNOLOGY,
THROUGH 2020 ($ MILLIONS) 62
TABLE 15 GLOBAL MARKET FOR GENOME EDITING BY PRODUCT TYPE, THROUGH
2020 ($ MILLIONS) 63
TABLE 16 U.S. MARKET FOR GENOME EDITING BY PRODUCT TYPE, THROUGH 2020
($ MILLIONS) 66
TABLE 17 EUROPEAN MARKET FOR GENOME EDITING BY PRODUCT TYPE, THROUGH
2020 ($ MILLIONS) 66
TABLE 18 ASIA-PACIFIC MARKET FOR GENOME EDITING BY PRODUCT TYPE,
THROUGH 2020 ($ MILLIONS) 67
TABLE 19 REST OF WORLD MARKET FOR GENOME EDITING BY PRODUCT TYPE,
THROUGH 2020 ($ MILLIONS) 67
TABLE 20 MAJOR COMPANIES THAT PROVIDE GENOME EDITING RELATED SERVICES,
AS OF JANUARY 31, 2016 69
TABLE 21 GLOBAL MARKET FOR GENOME EDITING SERVICES BY REGION, THROUGH
2020 ($ MILLIONS) 70
TABLE 22 GLOBAL MARKET FOR GENOME EDITING BY PRODUCT AND SERVICE,
THROUGH 2020 ($ MILLIONS) 72
TABLE 23 U.S. MARKET FOR GENOME EDITING BY PRODUCT AND SERVICE,
THROUGH 2020 ($ MILLIONS) 74
TABLE 24 EUROPEAN MARKET FOR GENOME EDITING BY PRODUCT AND SERVICE,
THROUGH 2020 ($ MILLIONS) 74
TABLE 25 ASIA-PACIFIC MARKET FOR GENOME EDITING BY PRODUCT AND SERVICE,
THROUGH 2020 ($ MILLIONS) 75
TABLE 26 REST OF WORLD MARKET FOR GENOME EDITING BY PRODUCT AND
SERVICE, THROUGH 2020 ($ MILLIONS) 75
TABLE 27 GLOBAL ACADEMIC RESEARCH MARKET FOR GENOME EDITING BY REGION,
THROUGH 2020 ($ MILLIONS) 78
TABLE 28 DISTRIBUTION OF GENOME EDITING PATENTS AND PATENT APPLICATIONS
AT USPTO BY COUNTRY (NUMBER/%) 80
TABLE 29 DISTRIBUTION OF U.S. GENOME EDITING PATENTS AND PATENT
APPLICATIONS AT WIPO BY STATE (NUMBER/%) 80
TABLE 30 DISTRIBUTION OF GENOME EDITING PATENTS AND PATENT APPLICATIONS
AT WIPO BY PATENT OFFICE (NUMBER/%) 81
TABLE 31 GENOME EDITING PATENTS AND PATENT APPLICATIONS AT USPTO BY
YEAR, 2007-2015 81
TABLE 32 GENOME EDITING PATENTS AND PATENT APPLICATIONS AT WIPO BY YEAR,
2007-2015 82
TABLE 33 GENOME EDITING PATENTS AND PATENT APPLICATIONS AT USPTO BY
TECHNOLOGY, 2007-2015 (NUMBER/%) 82
TABLE 34 NIH FUNDING FOR GENE/GENOME EDITING BY YEAR, 2007-2015 ($
MILLIONS) 85
TABLE 35 NIH-FUNDED RESEARCH GRANTS BY YEAR, 2007-2015 (NUMBER OF
GRANTS) 86
TABLE 36 GLOBAL DRUG DEVELOPMENT MARKET FOR GENOME EDITING BY REGION,
THROUGH 2020 ($ MILLIONS) 89
TABLE 37 GLOBAL PLANT BREEDING MARKET FOR GENOME EDITING BY REGION,
THROUGH 2020 ($ MILLIONS) 94
TABLE 38 GLOBAL MARKET FOR GENOME EDITING BY CLINICAL PRODUCT AND
NON-CLINICAL PRODUCT, THROUGH 2020 ($ MILLIONS) 99
TABLE 39 U.S. MARKET FOR GENOME EDITING BY CLINICAL PRODUCT AND
NON-CLINICAL PRODUCT, THROUGH 2020 ($ MILLIONS) 99
TABLE 40 EUROPEAN MARKET FOR GENOME EDITING BY CLINICAL PRODUCT AND
NON-CLINICAL PRODUCT, THROUGH 2020 ($ MILLIONS) 100
TABLE 41 ASIA-PACIFIC MARKET FOR GENOME EDITING BY CLINICAL PRODUCT AND
NON-CLINICAL PRODUCT, THROUGH 2020 ($ MILLIONS) 101
TABLE 42 REST OF WORLD MARKET FOR GENOME EDITING BY CLINICAL PRODUCT
AND NON-CLINICAL PRODUCT, THROUGH 2020 ($ MILLIONS) 101

LIST OF FIGURES

SUMMARY FIGURE GLOBAL GENOME EDITING MARKET BY REGION, 2014-2020 ($
MILLIONS) 8
FIGURE 1 DISTRIBUTION OF COMPANIES THAT HAVE GENOME EDITING RELATED
BUSINESSES BY REGION, AS OF JANUARY 2016 (%) 41
FIGURE 2 GLOBAL MARKET FOR GENOME EDITING BY REGION, 2014-2020 ($
MILLIONS) 43
FIGURE 3 GLOBAL GENOME EDITING MARKET SHARE BY REGION, 2014 (%) 43
FIGURE 4 GLOBAL GENOME EDITING MARKET SHARE BY REGION, 2020 (%) 44
FIGURE 5 GLOBAL MARKET SHARES FOR GENOME EDITING BY APPLICATION, 2014
(%) 46
FIGURE 6 GLOBAL MARKET SHARES FOR GENOME EDITING BY APPLICATION, 2020
(%) 46
FIGURE 7 U.S. MARKET SHARES FOR GENOME EDITING BY APPLICATION, 2014 (%) 48
FIGURE 8 U.S. MARKET SHARES FOR GENOME EDITING BY APPLICATION, 2020 (%) 49
FIGURE 9 EUROPEAN MARKET SHARES FOR GENOME EDITING BY APPLICATION,
2014 (%) 50
FIGURE 10 EUROPEAN MARKET SHARES FOR GENOME EDITING BY APPLICATION,
2020 (%) 50
FIGURE 11 ASIA-PACIFIC MARKET SHARES FOR GENOME EDITING BY APPLICATION,
2014 (%) 52
FIGURE 12 ASIA-PACIFIC MARKET SHARES FOR GENOME EDITING BY APPLICATION,
2020 (%) 52
FIGURE 13 GLOBAL MARKET SHARES FOR GENOME EDITING BY TECHNOLOGY, 2014
(%) 55
FIGURE 14 GLOBAL MARKET SHARES FOR GENOME EDITING BY TECHNOLOGY, 2020
(%) 55
FIGURE 15 U.S. MARKET SHARES FOR GENOME EDITING BY TECHNOLOGY, 2014 (%) 57
FIGURE 16 U.S. MARKET SHARES FOR GENOME EDITING BY TECHNOLOGY, 2020 (%) 57
FIGURE 17 EUROPEAN MARKET SHARES FOR GENOME EDITING BY TECHNOLOGY,
2014 (%) 59
FIGURE 18 EUROPEAN MARKET SHARES FOR GENOME EDITING BY TECHNOLOGY,
2020 (%) 59
FIGURE 19 ASIA-PACIFIC MARKET SHARES FOR GENOME EDITING BY TECHNOLOGY,
2014 (%) 61
FIGURE 20 ASIA-PACIFIC MARKET SHARES FOR GENOME EDITING BY TECHNOLOGY,
2020 (%) 61
FIGURE 21 GLOBAL MARKET SHARES FOR GENOME EDITING BY PRODUCT TYPE,
2014 (%) 64
FIGURE 22 GLOBAL MARKET SHARES FOR GENOME EDITING BY PRODUCT TYPE,
2020 (%) 64
FIGURE 23 GLOBAL MARKET SHARES FOR GENOME EDITING SERVICES BY REGION,
2014 (%) 70
FIGURE 24 GLOBAL MARKET SHARES FOR GENOME EDITING SERVICES BY REGION,
2020 (%) 71
FIGURE 25 GLOBAL MARKET SHARES FOR GENOME EDITING BY PRODUCT AND
SERVICE, 2014 (%) 73
FIGURE 26 GLOBAL MARKET SHARES FOR GENOME EDITING BY PRODUCT AND
SERVICE, 2020 (%) 73
FIGURE 27 GLOBAL ACADEMIC RESEARCH MARKET SHARES FOR GENOME EDITING
BY REGION, 2014 (%) 78
FIGURE 28 GLOBAL ACADEMIC RESEARCH MARKET SHARES FOR GENOME EDITING
BY REGION, 2020 (%) 79
FIGURE 29 GENOME EDITING PATENTS AND PATENT APPLICATIONS BY TECHNOLOGY,
2007-2015 (%) 82
FIGURE 30 NUMBER OF CRISPR PUBLICATIONS BY YEAR, 2005-2015 84
FIGURE 31 NUMBER OF ZFNS PUBLICATIONS BY YEAR, 2005-2015 84
FIGURE 32 NUMBER OF TALENS PUBLICATIONS BY YEAR, 2011-2015 84
FIGURE 33 NIH FUNDING FOR GENE/GENOME EDITING BY YEAR, 2007-2015 ($
MILLIONS) 85
FIGURE 34 NIH-FUNDED RESEARCH GRANTS BY YEAR, 2007-2015 (NUMBER OF
GRANTS) 86
FIGURE 35 GLOBAL DRUG DEVELOPMENT MARKET FOR GENOME EDITING BY
REGION, 2014 (%) 89
FIGURE 36 GLOBAL DRUG DEVELOPMENT MARKET FOR GENOME EDITING BY
REGION, 2020 (%) 90
FIGURE 37 GLOBAL PLANT BREEDING MARKET FOR GENOME EDITING BY REGION,
2014 (%) 94
FIGURE 38 GLOBAL PLANT BREEDING MARKET FOR GENOME EDITING BY REGION,
2020 (%) 95
FIGURE 39 GLOBAL CLINIC GENOME EDITING MARKET BY REGION, 2020 (%) 97
FIGURE 40 GLOBAL MARKET FOR GENOME EDITING BY CLINICAL PRODUCT AND
NON-CLINICAL PRODUCT, 2020 (%) 99

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