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This BCC Research report quantifies, analyzes and projects the future of the global market for process analytical technology (PAT) applications in the pharmaceutical industry. Furthermore, the report also covers the advances and innovations in PAT instrumentation and the progress of implementation of PAT in various segments of the pharmaceutical industry.

Use this report to:
- Focus on the PAT tools and techniques, their implementation, market activities and the benefits and challenges of implementing PAT.
- Receive the global and regional breakdown of sales/revenue data with the present and forecasted values.
- Learn about the advances and innovations in PAT instrumentation.
- Receive a view on the utilization of PAT instruments by the pharmaceutical industry, market leaders and their market shares.

Highlights
- The global market for process analytical technology (PAT) instrumentation in 2013 was $305.1 million, which is expected to reach about $326.3 million by year-end 2014. The
projected PAT instrumentation market is expected to be valued at around $450.6 million by 2019 at a compound annual growth rate (CAGR) of 6.7% for the period of 2014 to 2019.
- North America is expected to generate the highest revenue within the global market for PAT in 2014 with sales of nearly $137.2 million. This is expected to reach $190.3 million by 2019, at a CAGR of 6.8% for the period of 2014 to 2019.
- The European market is also expected to grow at a similar pace with a CAGR of 6.8% from 2014 to 2019, reaching about $139.1 million by 2019 from a value of $100.2 million in 2014.

Introduction & Scope

INTRODUCTION

STUDY OBJECTIVES
BCC Research’s objective in preparing this report is to quantify, analyze and project the future of the market for process analytical technology (PAT) applications in the pharmaceutical industry. Furthermore, the report also covers the advances and innovations in PAT instrumentation and the progress of implementation of PAT in various segments of the pharmaceutical industry. The market analysis and application of PAT solutions are drawn from the products available in the market, the launch of novel products and techniques, their usage and utility, and alliances, research and development and market opportunities.

The market for process analytical technologies (PATs) is still in a nascent stage and thus the market forecasts are based on the feasible implementation of the instruments
for various stages of pharmaceutical manufacturing and operations. The report, in addition to projecting the present market, also projects the future market for PAT instrumentation and techniques. Further, the report offers a view on the utilization of PAT instruments by the pharmaceutical industry, market leaders and market shares,
profiles of leading companies, alliances and mergers, patent analysis, regulatory aspects, advancements in technology platforms, new developments, opportunities and
challenges, and drivers and factors determining the PAT market.

Revenue and sales data for process analytical technologies are acquired from the annual reports of manufacturing companies and other relevant data sources. A market
analysis is done for the period from 2011 to 2013. Revenue projections are carried out for the year 2014 and 2019 with a detailed region-wise analysis for geographies such
as North America (U.S. and Canada), Europe, Asia-Pacific and the emerging markets.

REASONS FOR DOING THIS STUDY
In 2002, the U.S. Food and Drug Administration (FDA) introduced the PAT Initiative for the pharmaceutical industry. However, growth in the implementation of PAT has been
slow as can be seen from its market size of a little more than $300 million. The report offers insight into PAT tools and techniques, their implementation, market activities
and the benefits and challenges of implementing PAT. The PAT instrumentation market has immense prospects in the multibillion dollar pharmaceutical industry. The report
details some of the reasons behind its growth potential, with an emphasis on the requirement of PAT solutions from the perspective of their overall business benefits.

CONTRIBUTIONS OF THE STUDY AND INTENDED AUDIENCE
The report emphasizes the high potential the PAT instrumentation and techniques market holds for the pharmaceutical industry. The report offers a view on how the
implementation of the techniques will become necessary in ensuring the development of quality products. Advances in PAT technologies and increased implementation of
PAT solutions will primarily benefit the overall pharmaceutical industry along with drug developers/manufacturers, pharmaceutical and PAT solution development companies of all sizes, multinational companies, scientists, researchers, research organizations, educational institutes, government and non-government organization and others.

SCOPE OF THE STUDY
BCC Research carries out the market evaluation, the global and regional breakdown of sales/revenue data, market projection, current PAT solutions available in the market,
the present and prospective applications of PAT solutions, regulatory aspects, patent analysis, advantages and challenges, market leaders and market shares of the PAT
instrumentation and techniques market. Sales data for the global and markets for all geographies are corroborated for the present and forecasted values via statistical analysis and primary sources. Product information and the technologies/platforms in the report are based on their present/prospective application and practicality.

An abstract of the global PAT instrumentation and techniques market is provided in the report. In addition, the report presents sales analyses broken down geographically for
North America (U.S. and Canada), Europe, Asia-Pacific and the emerging markets. Applications of PAT tools are summed up from the perspective of commercial and R&D
usage.

Table Of Contents

Process Analytical Technologies for Pharmaceuticals: Global Markets
TABLE OF CONTENTS
CHAPTER 1 INTRODUCTION 2
STUDY OBJECTIVES 2
REASONS FOR DOING THIS STUDY 2
CONTRIBUTIONS OF THE STUDY AND INTENDED AUDIENCE 2
SCOPE OF THE STUDY 3
METHODOLOGY 3
INFORMATION SOURCES 3
ANALYSTS' CREDENTIALS 4
RELATED BCC RESEARCH REPORTS 4
BCC RESEARCH WEBSITE 5
DISCLAIMER 5
CHAPTER 2 EXECUTIVE SUMMARY 7
SUMMARY TABLE GLOBAL MARKET FOR PROCESS ANALYTICAL TECHNOLOGY
INSTRUMENTATION BY REGION, THROUGH 2019 ($ THOUSANDS) 8
SUMMARY FIGURE GLOBAL MARKET FOR PROCESS ANALYTICAL TECHNOLOGY
INSTRUMENTATION BY REGION, 2011-2019 ($ THOUSANDS) 8
CHAPTER 3 OVERVIEW 10
PAT PROCESS STEPS 11
FIGURE 1 PAT PROCESS STEPS 11
CLASSIFICATION 11
CHROMATOGRAPHY 12
High Performance Liquid Chromatography 13
Gas Chromatography 13
Gas Chromatography/Mass Spectrometry 14
Thin Layer Chromatography 14
TABLE 1 ADVANTAGES AND DISADVANTAGES OF CHROMATOGRAPHIC
TECHNIQUES 15
SPECTROPHOTOMETRY 17
Near-Infrared 17
Ultraviolet-Visible 18
Nuclear Magnetic Resonance 18
Atomic Absorption 18
Infrared 19
X-ray Diffraction 19
Mass Spectrometry 19
Raman Spectroscopy 20
TABLE 2 ADVANTAGES AND DISADVANTAGES OF SPECTROPHOTOMETRIC
TECHNIQUES 21
CAPILLARY ELECTROPHORESIS 24
Isoelectric Focusing 24
Isotachophoresis 25
TABLE 3 ADVANTAGES AND DISADVANTAGES OF CAPILLARY ELECTROPHORESIS
TECHNIQUES 25
PARTICLE SIZE ANALYSIS METHODS 26
Laser Diffraction 26
Microscopic 27
Photozone 27
Sieving 27
Size-Exclusion Chromatography 28
TABLE 4 ADVANTAGES AND DISADVANTAGES OF PARTICLE SIZE ANALYSIS
TECHNIQUES 28
DISSOLUTION METHODS 30
Automated 31
Ultraviolet-Visible/Ultraviolet 31
High Performance Liquid Chromatography 31
TABLE 5 ADVANTAGES AND DISADVANTAGES OF DISSOLUTION METHODS 32
AUTOMATED ANALYTICAL METHODS 32
Automated Analysis 33
Robots 33
Others 33
Automated Sample Preparation and Analysis 33
TABLE 6 ADVANTAGES AND DISADVANTAGES OF AUTOMATED ANALYTICAL
METHODS 34
TITRATION TOOLS 35
TABLE 7 ADVANTAGES AND DISADVANTAGES OF TITRATION TOOLS 35
PROCESS ANALYTICAL TECHNOLOGY IN THE PHARMACEUTICAL
MANUFACTURING PROCESS 35
RAW MATERIAL IDENTIFICATION 36
BLENDING 36
GRANULATION 36
DRYING 36
COMPRESSION 37
COATING 37
PACKAGING 37
TABLE 8 BENEFITS AND CONSIDERATIONS OF PROCESS ANALYTICAL TECHNOLOGY
FOR PHARMACEUTICAL PRODUCTS MANUFACTURING 38
FERMENTATION 38
CRYSTALLIZATION 39
LYOPHILIZATION 39
SOLVENT RECOVERY 39
DOWNSTREAM PROCESSING 39
MEASUREMENT BY PROCESS ANALYTICAL TECHNOLOGY TOOLS AND
TECHNIQUES 40
ACTIVE PHARMACEUTICAL INGREDIENT CONCENTRATION 40
CONTENT UNIFORMITY 40
COATING THICKNESS 41
BIOMASS MEASUREMENT 41
IMPURITY CONCENTRATION 41
OFF-GAS MONITORING 41
PURITY 42
LUBRICANT UNIFORMITY 42
MOISTURE 42
COATING COVERAGE 42
NUTRIENT CONCENTRATION 43
OPTICAL DENSITY 43
REACTION MONITORING 43
CHAPTER 4 REGULATORY ASPECTS 45
CATEGORIZATION OF TOOLS IN THE PAT FRAMEWORK 46
MULTIVARIATE TOOLS FOR DESIGN, DATA ACQUISITION AND ANALYSIS 46
PROCESS ANALYZERS 46
PROCESS CONTROL TOOLS 47
CONTINUOUS IMPROVEMENT AND KNOWLEDGE MANAGEMENT TOOLS 48
PAT SUPPORT IN EUROPE 49
EU PAT TEAM ACTIVITIES 49
REGULATORY COMPLIANCE AND DEVELOPMENTS OF PROCESS ANALYTICAL
TECHNOLOGIES FOR THE PHARMACEUTICAL INDUSTRY 50
CHAPTER 5 NEW DEVELOPMENTS 52
TABLE 9 NEW DEVELOPMENTS FOR PROCESS ANALYTICAL TECHNOLOGIES IN
PHARMACEUTICALS, 2013 THROUGH MARCH 2014 52
TABLE 10 AWARDS FOR PROCESS ANALYTICAL TECHNOLOGIES IN
PHARMACEUTICALS, 2013 THROUGH MARCH 2014 55
TABLE 11 NEW DEVELOPMENTS IN PROCESS ANALYTICAL TECHNOLOGIES FOR
PHARMACEUTICALS, 2012 57
TABLE 12 AWARDS FOR PROCESS ANALYTICAL TECHNOLOGIES IN
PHARMACEUTICALS, 2012 59
TABLE 13 NEW DEVELOPMENTS IN PROCESS ANALYTICAL TECHNOLOGIES FOR
PHARMACEUTICALS, 2011 60
TABLE 14 AWARDS FOR PROCESS ANALYTICAL TECHNOLOGIES IN
PHARMACEUTICALS, 2011 62
CHAPTER 6 MARKET ANALYSIS 66
MARKET BY PAT CATEGORY 66
TABLE 15 GLOBAL MARKET FOR PROCESS ANALYTICAL TECHNOLOGY
INSTRUMENTATION BY CATEGORY, THROUGH 2019 ($ THOUSANDS) 68
FIGURE 2 GLOBAL MARKET FOR PROCESS ANALYTICAL TECHNOLOGY
INSTRUMENTATION BY CATEGORY, 2011-2019 ($ THOUSANDS) 68
CHROMATOGRAPHIC TOOLS AND TECHNIQUES 69
Market Overview 69
Market Revenue 69
TABLE 16 CHROMATOGRAPHIC TOOLS AND TECHNIQUES MARKET BY TYPE,
THROUGH 2019 ($ THOUSANDS) 70
FIGURE 3 CHROMATOGRAPHIC TOOLS AND TECHNIQUES MARKET BY TYPE,
2011-2019 ($ THOUSANDS) 70
Gas Chromatography/Mass Spectrometry 70
Market Overview 71
Market Revenue 71
TABLE 17 GC/MS TOOLS AND METHODS MARKET BY REGION, THROUGH 2019 ($
THOUSANDS) 72
FIGURE 4 GC/MS TOOLS AND METHODS MARKET BY REGION, 2011-2019 ($
THOUSANDS) 72
Gas Chromatography 72
Market Overview 73
Market Revenue 73
TABLE 18 GAS CHROMATOGRAPHY TOOLS AND METHODS MARKET BY REGION,
THROUGH 2019 ($ THOUSANDS) 74
FIGURE 5 GAS CHROMATOGRAPHY TOOLS AND METHODS MARKET BY REGION,
2011-2019 ($ THOUSANDS) 74
High Performance Liquid Chromatography 75
Market Overview 75
Market Revenue 75
TABLE 19 HIGH PERFORMANCE LIQUID CHROMATOGRAPHY TOOLS AND METHODS
MARKET BY REGION, THROUGH 2019 ($ THOUSANDS) 76
FIGURE 6 HIGH PERFORMANCE LIQUID CHROMATOGRAPHY TOOLS AND METHODS
MARKET BY REGION, 2011-2019 ($ THOUSANDS) 76
Thin Layer Chromatography 77
Market Overview 77
Market Revenue 77
TABLE 20 THIN LAYER CHROMATOGRAPHY TOOLS AND METHODS MARKET BY
REGION, THROUGH 2019 ($ THOUSANDS) 78
FIGURE 7 THIN LAYER CHROMATOGRAPHY TOOLS AND METHODS MARKET BY
REGION, 2011-2019 ($ THOUSANDS) 78
SPECTROPHOTOMETRIC TOOLS AND TECHNIQUES 79
Market Overview 79
Market Revenue 79
TABLE 21 SPECTROPHOTOMETRIC TOOLS AND TECHNIQUES MARKET BY TYPE,
THROUGH 2019 ($ THOUSANDS) 80
FIGURE 8 SPECTROPHOTOMETRIC TOOLS AND TECHNIQUES MARKET BY TYPE,
2011-2019 ($ THOUSANDS) 80
Near-Infrared 81
Market Overview 81
Market Revenue 82
TABLE 22 NEAR-INFRARED TOOLS AND TECHNIQUES MARKET BY REGION,
THROUGH 2019 ($ THOUSANDS) 82
FIGURE 9 NEAR-INFRARED TOOLS AND TECHNIQUES MARKET BY REGION,
2011-2019 ($ THOUSANDS) 82
Ultraviolet-Visible 83
Market Overview 83
Market Revenue 84
TABLE 23 ULTRAVIOLET-VISIBLE TOOLS AND TECHNIQUES MARKET BY REGION,
THROUGH 2019 ($ THOUSANDS) 84
FIGURE 10 ULTRAVIOLET-VISIBLE TOOLS AND TECHNIQUES MARKET BY REGION,
2011-2019 ($ THOUSANDS) 84
Nuclear Magnetic Resonance 85
Market Overview 85
Market Revenue 86
TABLE 24 NUCLEAR MAGNETIC RESONANCE TOOLS AND TECHNIQUES MARKET BY
REGION, THROUGH 2019 ($ THOUSANDS) 86
FIGURE 11 NUCLEAR MAGNETIC RESONANCE TOOLS AND TECHNIQUES MARKET BY
REGION, 2011-2019 ($ THOUSANDS) 86
Atomic Absorption Spectrometry 87
Market Overview 87
Market Revenue 88
TABLE 25 ATOMIC ABSORPTION TOOLS AND TECHNIQUES MARKET BY REGION,
THROUGH 2019 ($ THOUSANDS) 88
FIGURE 12 ATOMIC ABSORPTION TOOLS AND TECHNIQUES MARKET BY REGION,
2011-2019 ($ THOUSANDS) 89
Infrared 89
Market Overview 89
Market Revenue 90
TABLE 26 INFRARED TOOLS AND TECHNIQUES MARKET BY REGION, THROUGH
2019 ($ THOUSANDS) 90
FIGURE 13 INFRARED TOOLS AND TECHNIQUES MARKET BY REGION, 2011-2019 ($
THOUSANDS) 90
X-ray Diffraction 91
Market Overview 91
Market Revenue 92
TABLE 27 X-RAY DIFFRACTION TOOLS AND TECHNIQUES MARKET BY REGION,
THROUGH 2019 ($ THOUSANDS) 92
FIGURE 14 X-RAY DIFFRACTION TOOLS AND TECHNIQUES MARKET BY REGION,
2011-2019 ($ THOUSANDS) 92
Mass Spectrometry 93
Market Overview 93
Market Revenue 94
TABLE 28 MASS SPECTROMETRY TOOLS AND TECHNIQUES MARKET BY REGION,
THROUGH 2019 ($ THOUSANDS) 94
FIGURE 15 MASS SPECTROMETRY TOOLS AND TECHNIQUES MARKET BY REGION,
2011-2019 ($ THOUSANDS) 94
Raman Spectroscopy 95
Market Overview 95
Market Revenue 96
TABLE 29 RAMAN SPECTROSCOPY TOOLS AND TECHNIQUES MARKET BY REGION,
THROUGH 2019 ($ THOUSANDS) 96
FIGURE 16 RAMAN SPECTROSCOPY TOOLS AND TECHNIQUES MARKET BY REGION,
2011-2019 ($ THOUSANDS) 96
CAPILLARY ELECTROPHORESIS 97
Market Overview 97
Market Revenue 98
TABLE 30 CAPILLARY ELECTROPHORESIS MARKET BY TYPE, THROUGH 2019 ($
THOUSANDS) 98
FIGURE 17 CAPILLARY ELECTROPHORESIS MARKET BY TYPE, 2011-2019 ($
THOUSANDS) 98
Isoelectric focusing 99
Market Overview 99
Market Revenue 100
TABLE 31 ISOELECTRIC FOCUSING TOOLS AND TECHNIQUES MARKET BY REGION,
THROUGH 2019 ($ THOUSANDS) 100
FIGURE 18 ISOELECTRIC FOCUSING TOOLS AND TECHNIQUES MARKET BY REGION,
2011-2019 ($ THOUSANDS) 100
Isotachophoresis 101
Market Overview 101
Market Revenue 102
TABLE 32 ISOTACHOPHORESIS TOOLS AND TECHNIQUES MARKET BY REGION,
THROUGH 2019 ($ THOUSANDS) 102
FIGURE 19 ISOTACHOPHORESIS TOOLS AND TECHNIQUES MARKET BY REGION,
2011-2019 ($ THOUSANDS) 102
PARTICLE SIZE ANALYSIS 103
Market Overview 103
Market Revenue 104
TABLE 33 PARTICLE SIZE ANALYSIS TOOLS AND TECHNIQUES MARKET BY TYPE,
THROUGH 2019 ($ THOUSANDS) 105
FIGURE 20 PARTICLE SIZE ANALYSIS TOOLS AND TECHNIQUES MARKET BY TYPE,
2011-2019 ($ THOUSANDS) 105
Laser Tools and Techniques 105
Market Overview 106
Market Revenue 106
TABLE 34 LASER TOOLS AND TECHNIQUES MARKET BY REGION, THROUGH 2019 ($
THOUSANDS) 107
FIGURE 21 LASER TOOLS AND TECHNIQUES MARKET BY REGION, 2011-2019 ($
THOUSANDS) 107
Microscopic Tools and Techniques 107
Market Overview 108
Market Revenue 108
TABLE 35 MICROSCOPIC TOOLS AND TECHNIQUES MARKET BY REGION, THROUGH
2019 ($ THOUSANDS) 108
FIGURE 22 MICROSCOPIC TOOLS AND TECHNIQUES MARKET BY REGION,
2011-2019 ($ THOUSANDS) 109
Size-Exclusion Chromatography Tools and Techniques 109
Market Overview 110
Market Revenue 110
TABLE 36 SIZE EXCLUSION CHROMATOGRAPHY TOOLS AND TECHNIQUES MARKET
BY REGION, THROUGH 2019 ($ THOUSANDS) 111
FIGURE 23 SIZE EXCLUSION CHROMATOGRAPHY TOOLS AND TECHNIQUES
MARKET BY REGION, 2011-2019 ($ THOUSANDS) 111
Photozone Tools and Techniques 111
Market Overview 112
Market Revenue 112
TABLE 37 PHOTOZONE TOOLS AND TECHNIQUES MARKET BY REGION, THROUGH
2019 ($ THOUSANDS) 113
FIGURE 24 PHOTOZONE TOOLS AND TECHNIQUES MARKET BY REGION, 2011-2019
($ THOUSANDS) 113
Sieving Tools and Techniques 113
Market Overview 114
Market Revenue 114
TABLE 38 SIEVING TOOLS AND TECHNIQUES MARKET BY REGION, THROUGH 2019
($ THOUSANDS) 115
FIGURE 25 SIEVING TOOLS AND TECHNIQUES MARKET BY REGION, 2011-2019 ($
THOUSANDS) 115
DISSOLUTION METHODS 115
Market Overview 116
Market Revenue 116
TABLE 39 DISSOLUTION METHOD TOOLS AND TECHNIQUES MARKET BY TYPE,
THROUGH 2019 ($ THOUSANDS) 117
FIGURE 26 DISSOLUTION METHOD TOOLS AND TECHNIQUES MARKET BY TYPE,
2011-2019 ($ THOUSANDS) 117
Automated Dissolution Tools and Techniques 117
Market Overview 118
Market Revenue 118
TABLE 40 AUTOMATED DISSOLUTION TOOLS AND TECHNIQUES MARKET BY
REGION, THROUGH 2019 ($ THOUSANDS) 119
FIGURE 27 AUTOMATED DISSOLUTION TOOLS AND TECHNIQUES MARKET BY
REGION, 2011-2019 ($ THOUSANDS) 119
Ultraviolet Dissolution Tools and Techniques 119
Market Overview 120
Market Revenue 120
TABLE 41 UV DISSOLUTION TOOLS AND TECHNIQUES MARKET BY REGION,
THROUGH 2019 ($ THOUSANDS) 121
FIGURE 28 UV DISSOLUTION TOOLS AND TECHNIQUES MARKET BY REGION,
2011-2019 ($ THOUSANDS) 121
HPLC Dissolution Tools and Techniques 121
Market Overview 122
Market Revenue 122
TABLE 42 HPLC DISSOLUTION TOOLS AND TECHNIQUES MARKET BY REGION,
THROUGH 2019 ($ THOUSANDS) 123
FIGURE 29 HPLC DISSOLUTION TOOLS AND TECHNIQUES MARKET BY REGION,
2011-2019 ($ THOUSANDS) 123
AUTOMATED ANALYTICAL METHODS 123
Market Overview 124
Market Revenue 124
TABLE 43 AUTOMATED ANALYTICAL METHODS TOOLS AND TECHNIQUES MARKET
BY TYPE, THROUGH 2019 ($ THOUSANDS) 124
FIGURE 30 AUTOMATED ANALYTICAL METHODS TOOLS AND TECHNIQUES MARKET
BY TYPE, 2011-2019 ($ THOUSANDS) 125
Automated Analysis 125
Market Overview 126
Market Revenue 126
TABLE 44 AUTOMATED ANALYSIS TOOLS AND TECHNIQUES MARKET BY REGION,
THROUGH 2019 ($ THOUSANDS) 127
FIGURE 31 AUTOMATED ANALYSIS TOOLS AND TECHNIQUES MARKET BY REGION,
2011-2019 ($ THOUSANDS) 127
Robotics 128
Market Overview 128
Market Revenue 128
TABLE 45 ROBOTICS TOOLS AND TECHNIQUES MARKET BY REGION, THROUGH
2019 ($ THOUSANDS) 129
FIGURE 32 ROBOTICS TOOLS AND TECHNIQUES MARKET BY REGION, 2011-2019 ($
THOUSANDS) 129
Other Automated Analytical Methods 130
Market Overview 130
Market Revenue 130
TABLE 46 OTHER AUTOMATED ANALYTICAL METHODS MARKET BY REGION,
THROUGH 2019 ($ THOUSANDS) 131
FIGURE 33 OTHER AUTOMATED ANALYTICAL METHODS MARKET BY REGION,
2011-2019 ($ THOUSANDS) 131
TITRATION TOOLS 131
Market Overview 132
Market Revenue 132
TABLE 47 TITRATION TOOLS AND TECHNIQUES MARKET BY REGION, THROUGH
2019 ($ THOUSANDS) 133
FIGURE 34 TITRATION TOOLS AND TECHNIQUES MARKET BY REGION, 2011-2019 ($
THOUSANDS) 133
MARKET SHARE 133
TABLE 48 MARKET SHARE OF PROCESS ANALYTICAL TECHNOLOGY
INSTRUMENTATION BY TYPE, 2013 (%) 134
FIGURE 35 MARKET SHARE OF PROCESS ANALYTICAL TECHNOLOGY
INSTRUMENTATION BY TYPE, 2013 (%) 134
MARKET BY REGION 134
MARKET OVERVIEW 135
MARKET REVENUE 136
TABLE 49 REGIONAL BREAKDOWN OF SALES OF PROCESS ANALYTICAL
TECHNOLOGY INSTRUMENTATION, THROUGH 2019 ($ THOUSANDS) 137
FIGURE 36 REGIONAL BREAKDOWN FOR SALES OF PROCESS ANALYTICAL
TECHNOLOGY INSTRUMENTATION, 2011-2019 ($ THOUSANDS) 137
MARKET SHARE 137
TABLE 50 MARKET SHARES OF PROCESS ANALYTICAL TECHNOLOGY
INSTRUMENTATION BY REGION, IN 2013 (%) 138
FIGURE 37 MARKET SHARES OF PROCESS ANALYTICAL TECHNOLOGY
INSTRUMENTATION BY REGION, IN 2013 (%) 138
CHAPTER 7 INDUSTRY STRUCTURE 140
CHROMATOGRAPHIC TOOLS AND TECHNIQUES 140
MARKET LEADERS 140
TABLE 51 LEADING MANUFACTURERS/SUPPLIERS OF PAT CHROMATOGRAPHIC
INSTRUMENTATION, 2013 140
MARKET SHARES 141
TABLE 52 MARKET SHARES OF MANUFACTURERS/SUPPLIERS OF
CHROMATOGRAPHIC TOOLS AND TECHNIQUES, 2013 (%) 142
FIGURE 38 MARKET SHARES OF MANUFACTURERS/SUPPLIERS OF
CHROMATOGRAPHIC TOOLS AND TECHNIQUES, 2013 (%) 142
SPECTROPHOTOMETRIC TOOLS AND TECHNIQUES 143
MARKET LEADERS 143
TABLE 53 LEADING MANUFACTURERS/SUPPLIERS OF PAT SPECTROPHOTOMETRIC
TOOLS AND TECHNIQUES, 2013 143
MARKET SHARES 145
TABLE 54 MARKET SHARES OF MANUFACTURERS/SUPPLIERS OF
SPECTROPHOTOMETRIC TOOLS AND TECHNIQUES, 2013 (%) 145
FIGURE 39 MARKET SHARES OF MANUFACTURERS/SUPPLIERS OF
SPECTROPHOTOMETRIC TOOLS AND TECHNIQUES, 2013 (%) 146
CAPILLARY ELECTROPHORESIS TOOLS AND TECHNIQUES 146
MARKET LEADERS 146
TABLE 55 LEADING MANUFACTURERS/SUPPLIERS OF PAT CAPILLARY
ELECTROPHORESIS TOOLS AND TECHNIQUES, 2013 147
MARKET SHARES 147
TABLE 56 MARKET SHARES OF MANUFACTURERS/SUPPLIERS OF CAPILLARY
ELECTROPHORESIS TOOLS AND TECHNIQUES, 2013 (%) 147
FIGURE 40 MARKET SHARES OF MANUFACTURERS/SUPPLIERS OF CAPILLARY
ELECTROPHORESIS TOOLS AND TECHNIQUES, 2013 (%) 147
PARTICLE SIZE ANALYSIS TOOLS AND TECHNIQUES 148
MARKET LEADERS 148
TABLE 57 LEADING MANUFACTURERS/SUPPLIERS OF PAT PARTICLE SIZE ANALYSIS
TOOLS AND TECHNIQUES, 2013 148
MARKET SHARES 150
TABLE 58 MARKET SHARES OF MANUFACTURERS/SUPPLIERS OF PARTICLE SIZE
ANALYSIS TOOLS AND TECHNIQUES, 2013 (%) 150
FIGURE 41 MARKET SHARES OF MANUFACTURERS/SUPPLIERS OF PARTICLE SIZE
ANALYSIS TOOLS AND TECHNIQUES, 2013 (%) 151
DISSOLUTION METHODS TOOLS AND TECHNIQUES 151
MARKET LEADERS 151
TABLE 59 LEADING MANUFACTURERS/SUPPLIERS OF PAT DISSOLUTION METHODS
TOOLS AND TECHNIQUES, 2013 151
MARKET SHARES 152
TABLE 60 MARKET SHARES OF MANUFACTURERS/SUPPLIERS OF DISSOLUTION
METHODS TOOLS AND TECHNIQUES, 2013 (%) 152
FIGURE 42 MARKET SHARES OF MANUFACTURERS/SUPPLIERS OF DISSOLUTION
METHODS TOOLS AND TECHNIQUES, 2013 (%) 152
AUTOMATED ANALYTICAL METHODS TOOLS AND TECHNIQUES 153
MARKET LEADERS 153
TABLE 61 LEADING MANUFACTURERS/SUPPLIERS OF PAT AUTOMATED ANALYTICAL
METHODS TOOLS AND TECHNIQUES, 2013 153
MARKET SHARES 155
TABLE 62 MARKET SHARES OF MANUFACTURERS/SUPPLIERS OF AUTOMATED
ANALYTICAL METHODS TOOLS AND TECHNIQUES, 2013 (%) 156
FIGURE 43 MARKET SHARES OF MANUFACTURERS/SUPPLIERS OF AUTOMATED
ANALYTICAL METHODS TOOLS AND TECHNIQUES, 2013 (%) 156
TITRATION TOOLS AND TECHNIQUES 157
MARKET LEADERS 157
TABLE 63 LEADING MANUFACTURERS/SUPPLIERS OF PAT TITRATION TOOLS AND
TECHNIQUES, 2013 157
MARKET SHARES 158
TABLE 64 MARKET SHARES OF MANUFACTURERS/SUPPLIERS OF TITRATION TOOLS
AND TECHNIQUES, 2013 (%) 158
FIGURE 44 MARKET SHARES OF MANUFACTURERS/SUPPLIERS OF TITRATION
TOOLS AND TECHNIQUES, 2013 (%) 158
CHAPTER 8 PROCESS ANALYTICAL TECHNOLOGY MARKET BY APPLICATION 161
INDUSTRIAL PHARMACEUTICAL MANUFACTURING 161
FIGURE 45 APPLICATION OF PAT IN PHARMACEUTICAL TABLET MANUFACTURING 161
PHARMACEUTICAL RESEARCH AND DEVELOPMENT 162
MARKET OVERVIEW 163
MARKET REVENUE 164
TABLE 65 GLOBAL MARKET FOR PROCESS ANALYTICAL TECHNOLOGY BY
APPLICATION, THROUGH 2019 ($ THOUSANDS) 165
FIGURE 46 GLOBAL MARKET FOR PROCESS ANALYTICAL TECHNOLOGY BY
APPLICATION, 2011-2019 ($ THOUSANDS) 165
MARKET SHARE 166
TABLE 66 MARKET SHARES OF PROCESS ANALYTICAL TECHNOLOGY BY
APPLICATION, 2013 (%) 166
FIGURE 47 MARKET SHARES OF PROCESS ANALYTICAL TECHNOLOGY BY
APPLICATION, IN 2013 (%) 166
CHAPTER 9 PATENT ANALYSIS 168
PATENTS BY YEAR 169
TABLE 67 NUMBER OF U.S. PATENTS ISSUED FOR PAT INSTRUMENTATION AND
METHODS FOR APPLICATION IN PHARMACEUTICALS BY YEAR, 2011-2013 (NUMBER
OF PATENTS)
169
FIGURE 48 NUMBER OF U.S. PATENTS ISSUED FOR PAT INSTRUMENTATION AND
METHODS FOR APPLICATION IN PHARMACEUTICALS BY YEAR, 2011-2013 (NUMBER
OF PATENTS)
169
PATENTS BY TYPE 170
TABLE 68 U.S. PATENTS ISSUED FOR PROCESS ANALYTICAL TECHNOLOGY
INSTRUMENTATION AND TECHNIQUES BY CATEGORY, 2011-2013 (NUMBER OF
PATENTS)
170
FIGURE 49 U.S. PATENTS ISSUED FOR PROCESS ANALYTICAL TECHNOLOGY
INSTRUMENTATION AND TECHNIQUES BY CATEGORY, 2011-2013 (NUMBER OF
PATENTS)
171
PATENTS BY COUNTRY 171
CHROMATOGRAPHIC TOOLS AND TECHNIQUES 171
TABLE 69 U.S. PATENTS ISSUED FOR CHROMATOGRAPHIC TOOLS AND
TECHNIQUES BY PATENT HOLDER'S COUNTRY, 2011-2013 (NUMBER OF PATENTS) 172
TABLE 70 SHARES OF U.S. PATENTS ISSUED FOR CHROMATOGRAPHIC TOOLS AND
TECHNIQUES BY PATENT HOLDER'S COUNTRY, 2011-2013 (NUMBER OF
PATENTS/%)
172
FIGURE 50 SHARES OF U.S. PATENT ISSUED FOR CHROMATOGRAPHIC TOOLS AND
TECHNIQUES BY PATENT HOLDER'S COUNTRY, 2011-2013 (%) 173
SPECTROPHOTOMETRIC TOOLS AND TECHNIQUES 173
TABLE 71 U.S. PATENTS ISSUED FOR SPECTROPHOTOMETRIC TOOLS AND
TECHNIQUES BY PATENT HOLDER'S COUNTRY, 2011-2013 (NUMBER OF PATENTS) 174
TABLE 72 SHARES OF U.S. PATENTS ISSUED FOR SPECTROPHOTOMETRIC TOOLS
AND TECHNIQUES BY PATENT HOLDER'S COUNTRY, 2011-2013 (NUMBER OF
PATENTS/%)
174
FIGURE 51 SHARES OF U.S. PATENTS ISSUED FOR SPECTROPHOTOMETRIC TOOLS
AND TECHNIQUES BY PATENT HOLDER'S COUNTRY, 2011-2013 (%) 175
CAPILLARY ELECTROPHORESIS TOOLS AND TECHNIQUES 176
TABLE 73 U.S. PATENTS ISSUED FOR CAPILLARY ELECTROPHORESIS TOOLS AND
TECHNIQUES BY PATENT HOLDER'S COUNTRY, 2011-2013 (NUMBER OF PATENTS) 176
TABLE 74 SHARES OF U.S. PATENTS ISSUED FOR CAPILLARY ELECTROPHORESIS
TOOLS AND TECHNIQUES BY PATENT HOLDER'S COUNTRY, 2011-2013 (NUMBER
OF PATENTS/%)
177
PARTICLE SIZE ANALYSIS TOOLS AND TECHNIQUES 177
TABLE 75 U.S. PATENTS ISSUED FOR PARTICLE SIZE ANALYSIS TOOLS AND
TECHNIQUES BY PATENT HOLDER'S COUNTRY, 2011-2013 (NUMBER OF PATENTS) 177
TABLE 76 SHARES OF U.S. PATENTS ISSUED FOR PARTICLE SIZE ANALYSIS TOOLS
AND TECHNIQUES BY PATENT HOLDER'S COUNTRY, 2011-2013 (NUMBER OF
PATENTS/%)
178
FIGURE 52 SHARES OF U.S. PATENTS ISSUED FOR PARTICLE SIZE ANALYSIS TOOLS
AND TECHNIQUES BY PATENT HOLDER'S COUNTRY, 2011-2013 (%) 179
DISSOLUTION METHODS TOOLS AND TECHNIQUES 179
TABLE 77 U.S. PATENTS ISSUED FOR DISSOLUTION METHODS TOOLS AND
TECHNIQUES BY PATENT HOLDER'S COUNTRY, 2011-2013 (NUMBER OF PATENTS) 179
TABLE 78 SHARES OF U.S. PATENTS ISSUED FOR DISSOLUTION METHODS TOOLS
AND TECHNIQUES BY PATENT HOLDER'S COUNTRY, 2011-2013 (NUMBER OF
PATENTS/%)
180
FIGURE 53 SHARES OF U.S. PATENTS ISSUED FOR DISSOLUTION METHODS TOOLS
AND TECHNIQUES BY PATENT HOLDER'S COUNTRY, 2011-2013 (%) 181
AUTOMATED ANALYTICAL METHODS TOOLS AND TECHNIQUES 181
TABLE 79 U.S. PATENTS ISSUED FOR AUTOMATED ANALYTICAL METHODS TOOLS
AND TECHNIQUES BY PATENT HOLDER'S COUNTRY, 2011-2013 (NUMBER OF
PATENTS)
181
TABLE 80 SHARES OF U.S. PATENTS ISSUED FOR AUTOMATED ANALYTICAL
METHODS TOOLS AND TECHNIQUES BY PATENT HOLDER'S COUNTRY, 2011-2013
(NUMBER OF PATENTS/%)
182
FIGURE 54 SHARES OF U.S. PATENTS ISSUED FOR AUTOMATED ANALYTICAL
METHODS TOOLS AND TECHNIQUES BY PATENT HOLDER'S COUNTRY, 2011-2013
(%)
183
TITRATION TOOLS AND TECHNIQUES 183
TABLE 81 U.S. PATENTS ISSUED FOR TITRATION TOOLS AND TECHNIQUES TO U.S.
PATENT HOLDERS, 2011-2013 (NUMBER OF PATENTS) 183
TABLE 82 PATENT SHARES BY COUNTRY FOR TITRATION TOOLS AND TECHNIQUES,
2011-2013 (NUMBER OF PATENTS/%) 184
PATENTS BY COMPANY 184
CHROMATOGRAPHIC TOOLS AND TECHNIQUES 184
TABLE 83 U.S. PATENTS ISSUED FOR CHROMATOGRAPHIC TOOLS AND
TECHNIQUES BY COMPANY, 2011-2013 (NUMBER OF PATENTS) 185
SPECTROPHOTOMETRIC TOOLS AND TECHNIQUES 186
TABLE 84 U.S. PATENTS ISSUED FOR SPECTROPHOTOMETRIC TOOLS AND
TECHNIQUES BY COMPANY, 2011-2013 (NUMBER OF PATENTS) 187
CAPILLARY ELECTROPHORESIS TOOLS AND TECHNIQUES 191
TABLE 85 U.S. PATENTS ISSUED FOR CAPILLARY ELECTROPHORESIS TOOLS AND
TECHNIQUES BY COMPANY, 2011-2013 (NUMBER OF PATENTS) 191
PARTICLE SIZE ANALYSIS TOOLS AND TECHNIQUES 192
TABLE 86 U.S. PATENTS ISSUED FOR PARTICLE SIZE ANALYSIS TOOLS AND
TECHNIQUES BY COMPANY, 2011-2013 (NUMBER OF PATENTS) 192
DISSOLUTION METHODS TOOLS AND TECHNIQUES 193
TABLE 87 U.S. PATENTS ISSUED FOR DISSOLUTION METHODS TOOLS AND
TECHNIQUES BY COMPANY, 2011-2013 (NUMBER OF PATENTS) 194
AUTOMATED ANALYTICAL METHODS TOOLS AND TECHNIQUES 195
TABLE 88 U.S. PATENTS ISSUED FOR AUTOMATED ANALYTICAL METHODS TOOLS
AND TECHNIQUES BY COMPANY, 2011-2013 (NUMBER OF PATENTS) 195
TITRATION TOOLS AND TECHNIQUES 197
TABLE 89 U.S. PATENTS ISSUED FOR TITRATION TOOLS AND TECHNIQUES BY
COMPANY, 2011-2013 (NUMBER OF PATENTS) 197
PATENTS BY ASSIGNEE 197
CHROMATOGRAPHIC TOOLS AND TECHNIQUES 197
TABLE 90 U.S. PATENTS ISSUED FOR CHROMATOGRAPHIC TOOLS AND
TECHNIQUES BY TYPE OF ASSIGNEE, 2011-2013 (NUMBER OF PATENTS) 197
SPECTROPHOTOMETRIC TOOLS AND TECHNIQUES 198
TABLE 91 U.S. PATENTS ISSUED FOR SPECTROPHOTOMETRIC TOOLS AND
TECHNIQUES BY TYPE OF ASSIGNEE, 2011-2013 (NUMBER OF PATENTS) 198
FIGURE 55 U.S. PATENTS ISSUED FOR SPECTROPHOTOMETRIC TOOLS AND
TECHNIQUES BY TYPE OF ASSIGNEE, 2011-2013 (NUMBER OF PATENTS) 198
CAPILLARY ELECTROPHORESIS TOOLS AND TECHNIQUES 199
TABLE 92 U.S. PATENTS ISSUED FOR CAPILLARY ELECTROPHORESIS TOOLS AND
TECHNIQUES BY TYPE OF ASSIGNEE, 2011-2013 (NUMBER OF PATENTS) 199
PARTICLE SIZE ANALYSIS TOOLS AND TECHNIQUES 199
TABLE 93 U.S. PATENTS ISSUED FOR PARTICLE SIZE ANALYSIS TOOLS AND
TECHNIQUES BY TYPE OF ASSIGNEE, 2011-2013 (NUMBER OF PATENTS) 199
FIGURE 56 U.S. PATENTS ISSUED FOR PARTICLE SIZE ANALYSIS TOOLS AND
TECHNIQUES BY TYPE OF ASSIGNEE, 2011-2013 (NUMBER OF PATENTS) 199
DISSOLUTION METHODS TOOLS AND TECHNIQUES 200
TABLE 94 U.S. PATENTS ISSUED FOR DISSOLUTION METHODS TOOLS AND
TECHNIQUES BY TYPE OF ASSIGNEE, 2011-2013 (NUMBER OF PATENTS) 200
AUTOMATED ANALYTICAL METHODS TOOLS AND TECHNIQUES 201
TABLE 95 U.S. PATENTS ISSUED FOR AUTOMATED ANALYTICAL METHODS TOOLS
AND TECHNIQUES BY TYPE OF ASSIGNEE, 2011-2013 (NUMBER OF PATENTS) 201
FIGURE 57 U.S. PATENTS ISSUED FOR AUTOMATED ANALYTICAL METHODS TOOLS
AND TECHNIQUES BY TYPE OF ASSIGNEE, 2011-2013 (NUMBER OF PATENTS) 201
TITRATION TOOLS AND TECHNIQUES 202
TABLE 96 U.S. PATENTS ISSUED FOR TITRATION TOOLS AND TECHNIQUES BY TYPE
OF ASSIGNEE, 2011-2013 (NUMBER OF PATENTS) 202
CHAPTER 10 CURRENT SITUATION 204
NEW TECHNOLOGIES AND PLATFORMS IN PROCESS ANALYTICAL TECHNOLOGY
IMPLEMENTATION 204
DIONEX INTEGRAL PLATFORM 205
NANOPARTICLE TRACKING ANALYSIS 205
NEXION ENHANCED SECURITY SOFTWARE 205
LABSOLUTIONS DIRECT FUNCTION 205
ZYMARK MULTIDOSE AUTOMATED DISSOLUTION PLATFORM 206
FACTORS AFFECTING THE PROCESS ANALYTICAL TECHNOLOGY MARKET 206
CURRENT DRIVERS OF PROCESS ANALYTICAL TECHNOLOGY MARKET 206
COLLABORATIONS/ACQUISITIONS 207
CHAPTER 11 COMPANY PROFILES 210
CHAPTER 12 APPENDIX I: ABBREVIATIONS 246

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