Bio-Detection HLS-HLD Technologies & Global Markets – 2011-2016

  • December 2010
  • -
  • Homeland Security Research Corporation (HSRC)

$5.6 Billion by 2016
Over the next six years, Homeland Security Research Corporation (HSRC) forecasts that, led by the US, Germany, France, China, Japan and India, the annual global bio-detection market (including systems sale, service, upgrades and consumables) will grow to $5.6 billion by 2016 at a CAGR of 12%.
With terrorist organizations posting secure “how-to” bio-agent production manuals to the Internet for download by individual terorists, governments have an urgent need to upgrade their bio-defense infrastructure. As President Obama stated: “Just as we must guard against the spread of nuclear terrorism, it is time for a comprehensive effort to tackle bio-terror”. Meeting this challenge will require, among other things, shortening the bio-attack alarm response time at a reasonable cost of ownership
Developed using HSRC’s tested methodology, The report delves into:
Global bio-detection by systems, upgrade, service and consumables market segments
Global & regional markets by first, second and third generation technology
Global & regional markets by indoor, outdoor, hand-held and mobile labs segment
Leading global bio-security projects
Current and pipeline technologies: e.g., advanced collectors-concentrators, reagent-less triggers, DNA-based diagnostics, antigen/anti-body methods, signal analysis algorithms
Regional markets: e.g., USA, UK, Germany, France, Italy, Spain, China, Taiwan, Japan, India, Middle East
Business opportunities: e.g., emerging threats, human and animal sentinel surveillance, reagent-less detection assays, bio-detection IC3 systems
A comprehensive review of Bio-Detection vendors , products and prices
Market drivers and inhibitors
And much more…

Table Of Contents

1 Executive Summary 25
1.1 Main Findings 25
1.2 Main Conclusions 31
1.3 Global Bio-Detection Market - 2011-2016 35
1.3.1 Global Systems, Service and Upgrade Markets - 2011-2016 35
1.3.2 Markets by Countries and Regions - 2011-2016 37
1.3.3 Markets by Outdoor, Indoor, Hand-Held and Mobile Lab - 2011-2016 39
1.3.4 Systems Market by Technology Generation - 2011-2016 40
1.3.5 Service and Upgrade Market by Generation - 2011-2016 42
1.4 Business Opportunities 44
1.4.1 Bio-Surveillance, Detection and Bio-forensics Business Challenges - 2011-2016 45
1.5 Technology Outlook 49
2 Introduction 50
2.1 Scope 50
2.2 Who is This Report For? 50
2.3 Methodology 51
2.4 Terms of Reference 54
3 Bio-Terror 56
4 Forty Countries: Bio-Security Status Review 57
4.1 Background 57
4.2 Forty Countries Bio-Technology and Bio-Defense Performance Score 57
5 Bio-Detection Market Drivers 59
6 Bio-Detection Market Inhibitors 61
7 Bio-Detection Industry Competitive Analysis 62
8 Industry SWOT Analysis 63
8.1 Scope 63
8.2 SWOT Analysis 64
9 The Bio-Detection Process 65
9.1 Sampling the Environment 65
9.2 Bio-Detectors in a Multitude of Ambient Settings 66
9.3 Bio-Detection Triggering 66
9.4 Sample Collection 66
9.5 Bio-Particle Detectors 67
9.6 Bio-Agent Identification 68
10 Bio-Detection Technological Challenges 69
10.1 Challenge 1 - Detection of Small Particle Concentration 70
10.2 Challenge 2 - Bio-Background Suppression 71
10.3 Challenge 3 - Expensive Reagents 71
10.4 Challenge 4 - Expensive Equipment Maintenance 71
10.5 Challenge 5 - Adapting Equipment to Changing Environments 72
10.6 Challenge 6 - Dealing With Emerging Threats 72
11 Present and Pipeline Bio-Detection Technologies 73
11.1 Bio-Detection - Core Technologies Comparison 73
11.2 Collector/Concentrator Core Technologies 76
11.3 Cyclone Collectors 76
11.4 Variable Particle-Size Impactor 77
11.5 Virtual Impactors 77
11.6 Impingers 78
11.7 Reagent-less Trigger Core Technologies 78
11.7.1 Flow Cytometry 79
11.7.2 Particle Sizing 80
11.7.3 Gas Chromatography 80
11.7.4 Trigger Technologies - Drivers 81
11.7.5 Trigger Technologies - Inhibitors 81
11.8 DNA Based Diagnostic Core Technologies 82
11.8.1 Overview of DNA-Based Detection 82
11.8.2 Polymerase Chain Reaction (PCR) 83
11.8.3 DNA / RNA Microarrays 87
11.8.4 DNA Technology Drivers 89
11.8.5 DNA Technology Inhibitors 89
11.9 Antibody-Antigen Diagnostic Core Technologies 89
11.9.1 Overview of Antibody-Antigen Reaction 89
11.9.2 Hand-Held Immuno-Chromatographic Assays (HHA) 90
11.9.3 Magnetic Microbead-Base Assays 91
11.9.4 Microfluidic Devices - “Lab on a Chip” 91
11.9.5 Fluorescence Imaging 92
11.9.6 Electrochemical-Luminescence (ECL) 92
11.9.7 Antibody/Antigen Technology - Drivers 92
11.9.8 Antibody/Antigen Technology - Inhibitors 92
11.1 Signal Analysis Algorithms 93
11.10.1 Clustering / Classifier Algorithms 93
11.10.2 Image Analysis Algorithms 93
11.10.3 Decision Algorithms 93
11.10.4 Drivers 93
11.10.5 Inhibitors 94
11.11 Rapid Microbiological Technologies 94
12 Bio- Detection - Analysis by Application 96
12.1.1 Application 1 - Emergency Responder Hand-Held Detectors 96
12.1.2 Application 2 - Emergency Responder Mobile Labs 97
12.1.3 Application 3 - Indoor Standoff Detectors 98
12.1.4 Application 4 - Outdoor Standoff Detectors 99
13 Global Bio- Detection Market - 2011-2016 100
13.1 The Global Market Overview 100
13.2 Market by Systems, Upgrade and Service Segments - 2011-2016 101
13.3 Global Market by Countries and Regions - 2011-2016 103
13.4 Global Systems Market by Technological Generation - 2011-2016 106
13.5 Global Systems Market by Indoor, Outdoor, Hand-Held and Mobile Labs Segments - 2011-2016 109
13.6 Global Service and Upgrade Market - 2011-2016 111
13.6.1 Global Service and Upgrade Business by Technological Generation - 2011-2016 111
13.6.2 Global Service and Upgrade Market by Indoor, Outdoor, Hand-Held and Mobile Labs Segments - 2011-2016 113
14 US Bio-Detection Market - 2011-2016 116
14.1 US Bio-Defense Background and Analysis 116
14.2 The Obama Administration Bio Terror Mitigation Strategy 118
14.3 Biosurveillance Network 119
14.4 Bio-Defense Funding 121
14.4.1 Overview 121
14.4.2 DHHS Bio-Defense Missions and Funding 124
14.4.3 DHS Bio-Defense Missions and Funding 124
14.4.4 DOD Bio-Defense Missions and Funding 125
14.4.5 DOA Bio-Defense Missions and Funding 125
14.4.6 EPA Bio-Defense Missions and Funding 125
14.5 Leading Bio-Security Projects 126
14.5.1 Project BioWatch 126
14.5.2 Project BioSense 127
14.5.3 Project BioShield 128
14.6 Market Drivers 129
14.7 Market Inhibitors 129
14.8 US Bio-Detection Systems Market - 2011-2016 130
14.8.1 Sales by Generation Forecast 130
14.8.2 US Bio-Detection Systems Market by Modality Forecast 132
14.9 US Outdoor Standoff Bio-Detection Systems Market - 2011-2016 135
14.9.1 Sales Outlook 135
14.1 US Indoor Bio-Detection Systems Market - 2011-2016 137
14.10.1 Indoor Market Outlook 138
14.11 US Hand-Held Detection Systems Market - 2011-2016 140
14.11.1 Hand-Held Detection Systems Market Outlook 140
14.12 US Mobile Bio-Detection Labs Market - 2011-2016 142
14.12.1 Market Outlook 142
14.13 US Service Business - 2011-2016 144
14.13.1 Service and Upgrade Business by Modality - 2011-2016 144
14.13.2 Service Business by Generation - 2011-2016 145
15 The UK, Germany, France, Italy and Spain HLS-HLD Bio-Detection Market 148
15.1 The European Union 148
15.1.1 The European Union Bio-Defense Background 148
15.1.2 EU Program of Cooperation on Preparedness and Response to Biological and Chemical Agent Attacks (BICHAT) 151
15.1.3 EU Bio-Defense Research Programs 152
15.2 The UK 153
15.2.1 Bio-Defense Strategy 153
15.2.2 Main Bio-Defense Initiatives 155
15.3 Germany 156
15.3.1 Bio-Defense Strategy 156
15.3.2 Main Bio-Defense Initiatives 157
15.3.3 Bio- Detection RandD Projects 159
15.4 France 162
15.5 Italy 163
15.6 Spain 163
15.7 Market Drivers 164
15.8 Market Inhibitors 164
15.9 UK, Germany, France, Italy and Spain Bio-Detection Systems Market - 2011-2016 165
15.9.1 Sales by Technology Generations Forecast 165
15.9.2 Sales by Modality Forecast 167
15.1 UK, Germany, France, Italy and Spain Outdoor Standoff Bio-Detection Systems Market Forecast - 2011-2016 170
15.10.1 Systems Market Outlook 170
15.11 UK, Germany, France, Italy and Spain Indoor Bio-Detection Systems Market - 2011-2016 172
15.11.1 Systems Market Outlook 173
15.12 UK, Germany, France, Italy and Spain Hand-Held Detection Systems Market - 2011-2016 174
15.12.1 Systems Market Outlook 175
15.13 UK, Germany, France, Italy and Spain Mobile Bio-Detection Labs Market - 2011-2016 177
15.13.1 Market Outlook 177
15.14 UK, Germany, France, Italy and Spain Service Business - 2011-2016 180
15.14.1 Service and Upgrade Business by Modality - 2011-2016 180
15.14.2 Service Business by Generation - 2011-2016 182
16 China, Taiwan, Japan, India and Middle East HLS-HLD Bio-Detection Market 185
16.1 Asian Countries Bio- Defense Background 185
16.2 Japan 185
16.3 China 187
16.4 Taiwan 188
16.5 India 189
16.6 Singapore 190
16.7 Middle East 191
16.8 Market Drivers 191
16.9 Market Inhibitors 192
16.1 China, Taiwan, Japan, India and Middle East Bio-Detection Systems Market - 2011-2016 192
16.10.1 Sales by Technology Generation - 2011-2016 192
16.10.2 Market by Modality - 2011-2016 194
16.11 China, Taiwan, Japan, India and Middle East Bio-Detection Outdoor Systems Market - 2011-2016 196
16.11.1 Sales Outlook 196
16.12 China, Taiwan, Japan, India and Middle East Bio-Detection Indoor Systems Market - 2011-2016 198
16.12.1 Market Outlook 199
16.13 China, Taiwan, Japan, India and Middle East Hand-Held Detection Systems Market - 2011-2016 201
16.13.1 Market Outlook 201
16.14 China, Taiwan, Japan, India and Middle East Bio-Detection Mobile Labs Market - 2011-2016 203
16.14.1 Market Outlook 203
16.15 China, Taiwan, Japan, India and Middle East Service Business - 2011-2016 205
16.15.1 Service and Upgrade Business by Modality - 2011-2016 205
16.15.2 Service Business by Generation - 2011-2016 207
17 The Rest of the World HLS-HLD Bio-Detection Market 210
17.1 ROW: Bio-Defense Background 210
17.1.1 Russia and CIS 210
17.1.2 Russian Government Bio-Security Initiatives 211
17.1.3 International Science and Technology Center (ISTC) 212
17.1.4 Canada 213
17.1.5 Australia 214
17.2 Market Drivers 214
17.3 Market Inhibitors 215
17.4 ROW Bio-Detection Systems Market - 2011-2016 215
17.4.1 Sales Forecast by Generation 215
17.4.2 Market by Modality Forecast 217
17.5 ROW Outdoor Bio-Detection Systems Market - 2011-2016 219
17.5.1 Sales Outlook 219
17.6 ROW Indoor Bio-Detection Systems Market - 2011-2016 221
17.6.1 Market Outlook 221
17.7 ROW Hand-Held Detection Systems Market - 2011-2016 223
17.7.1 ROW Market Outlook 223
17.8 ROW Mobile Bio-Detection Labs Market - 2011-2016 225
17.8.1 Market Outlook 225
17.9 ROW Service Business - 2011-2016 227
17.9.1 ROW Service and Upgrade Business by Modality 227
17.9.2 Service Business by Generation - 2011-2016 229
18 Bio-Detection Business Opportunities - 2011-2016 232
18.1 Historical Perspective: A Market Waiting for Transition 232
18.1.1 The Current and Future HLS Bio-Defense Strategy for Detection 232
18.1.2 Factors Affecting Biological Detectors Deployment and Technologies - 2011-2016 233
18.1.3 Biological Detection Technology Timeline 235
18.2 Business Opportunities for Next Generation HLS Bio-Detection Systems 236
18.2.1 Business Opportunity 1 - Emerging Threats 236
18.2.2 Business Opportunity 2 - Human Sentinel Surveillance System 237
18.2.3 Business Opportunity 3 - Animal Sentinel Surveillance System 237
18.2.4 Business Opportunity 4 - Biological IC3 - Biological Threat Assessment Intelligence Command, Control, and Communication Infrastructure 238
18.2.5 Business Opportunity 5 - Reducing False Alarms - Less False Positives and False Negatives 238
18.2.6 Business Opportunity 6 - Reducing Cost - Minimizing Use of Non-Reusable Reagents 238
18.3 Outdoor Standoff Biological Detectors 239
18.3.1 Business Opportunity 7 - Bio-agent Autonomous Networked Detectors (BAND) 239
18.3.2 Business Opportunity 8 - Rapid Automated Biological Identification System (RABIS) 240
18.3.3 Business Opportunity 9 - First Responder Portable Hand-Held Detector 240
18.3.4 Business Opportunity 10 - First-Responder Mobile Biological Detection Station 241
18.3.5 Business Opportunity 11 - Regional Automatic Detector - Outdoor Standoff Detectors 242
18.3.6 Business Opportunity 12 - Networked Automatic Detector - Indoor Standoff Detectors 243
18.3.7 Business Opportunity 13 - External Dissemination of Bio-Agent Detection 243
18.3.8 Business Opportunity 14 - Internal Dissemination of Bio-Agent 244
18.4 Other Bio-Detection Technologies - Business Opportunities 244
18.4.1 Business Opportunity 15 - “Lab on a Chip” - Miniature Detection Devices 244
18.4.2 Business Opportunity 16 - Reagent-less Specific Detection Assays 245
18.4.3 Business Opportunity 17 - Laser-Induced Breakdown Spectroscopy (LIBS) 246
18.4.4 Business Opportunity 18 - Raman Spectroscopy-based Reagent-less Detection 246
18.5 Future Technologies and Systems 246
19 Vendors 247
19.1 20/20 GeneSystems Inc. 247
19.2 Advnt Biotechnologies 248
19.3 Agilent Technologies 249
19.4 Alexeter Technologies 250
19.5 ANP Technologies, Inc. 251
19.6 BAS - Biological Alarm Systems Ltd. (Israel) 251
19.7 BD Biosciences Immunocytometry Systems 253
19.8 Bertin Technologies 253
19.9 BioDefense Corporation 254
19.1 BioDETECT AS 255
19.11 BioSentinel Pharmaceuticals LLC 256
19.12 3M Microbiology (Biotrace International, Ltd.) 257
19.13 BioTraces, Inc. 257
19.14 BioVeris Corporation 258
19.15 Biral 259
19.16 Cepheid 259
19.17 Commonwealth Biotechnologies, Inc. 260
19.18 Dycor Technologies Ltd. 260
19.19 Environics Oy 261
19.2 Evogen, Inc. 263
19.21 General Dynamics Canada 264
19.22 GenPrime, Inc. 265
19.23 Groton Biosystems 266
19.24 Haztech Systems, Inc. 267
19.25 Idaho Technology, Inc. 268
19.26 JMAR Technologies, Inc. 269
19.27 New Horizons Diagnostics 270
19.28 Proengin 271
19.29 QTL Biodetection 271
19.3 Research International 272
19.31 Response Biomedical 273
19.32 Roche Applied Science 273
19.33 Smiths Detection 274
19.34 Tetracore, Inc. 276
20 Prices of Bio-Detection Equipment 278
21 Appendix A: The Threat of Bio-Terror 281
21.1 Biological Terror 281
21.2 Bio-Weapons - Historical Perspective 282
21.3 Biological Terror - Bacterial Agents 284
21.3.1 Anthrax 284
21.3.2 Cholera 285
21.3.3 Plague 286
21.3.4 Tularemia 287
21.4 Biological Terror - Viral Agents 288
21.4.1 Smallpox 288
21.4.2 Hemorrhagic Fever Viruses 289
21.4.3 Venezuelan Equine Encephalitis 291
21.5 Biological Terror - Rickettsiae Agents 292
21.5.1 Q Fever 293
21.5.2 Typhus 293
21.6 Biological Terror - Toxins 294
21.6.1 Botulinum Toxin 294
21.6.2 Ricin 295
21.6.3 Saxitoxin 295
21.6.4 Staphylococcal Enterotoxin B (SEB) 296
22 Appendix B: Legal Issues 297
22.1 International / European Legislation / Agreements 297
22.1.1 The Biological and Toxin Weapons Convention (BTWC) 1972 297
22.2 U.S. Bioterrorism Legislation 302
22.3 The European Treaties and Legislation 305
22.3.1 EU Program of Cooperation on Preparedness and Response to Biological and Chemical Agent Attacks (BICHAT)

Companies Mentioned
1. 20/20 GeneSystems Inc.
2. Advnt Biotechnologies
3. Agilent Technologies
4. Alexeter Technologies
5. ANP Technologies, Inc.
6. BAS - Biological Alarm Systems Ltd. (Israel)
7. BD Biosciences Immunocytometry Systems
8. Bertin Technologies
9. BioDefense Corporation
10. BioDETECT AS
11. BioSentinel Pharmaceuticals LLC
12. 3M Microbiology (Biotrace International, Ltd.)
13. BioTraces, Inc.
14. BioVeris Corporation
15. Biral
16. Cepheid
17. Commonwealth Biotechnologies, Inc.
18. Dycor Technologies Ltd.
19. Environics Oy
20. Evogen, Inc.
21. General Dynamics Canada
22. GenPrime, Inc.
23. Groton Biosystems
24. Haztech Systems, Inc.
25. Idaho Technology, Inc.
26. JMAR Technologies, Inc.
27. New Horizons Diagnostics
28. Proengin
29. QTL Biodetection
30. Research International
31. Response Biomedical
32. Roche Applied Science
33. Smiths Detection
34. Tetracore, Inc.

2. Advnt Biotechnologies
3. Agilent Technologies
4. Alexeter Technologies
5. ANP Technologies, Inc.
6. BAS - Biological Alarm Systems Ltd. (Israel)
7. BD Biosciences Immunocytometry Systems
8. Bertin Technologies
9. BioDefense Corporation
10. BioDETECT AS
11. BioSentinel Pharmaceuticals LLC
12. 3M Microbiology (Biotrace International, Ltd.)
13. BioTraces, Inc.
14. BioVeris Corporation
15. Biral
16. Cepheid
17. Commonwealth Biotechnologies, Inc.
18. Dycor Technologies Ltd.
19. Environics Oy
20. Evogen, Inc.
21. General Dynamics Canada
22. GenPrime, Inc.
23. Groton Biosystems
24. Haztech Systems, Inc.
25. Idaho Technology, Inc.
26. JMAR Technologies, Inc.
27. New Horizons Diagnostics
28. Proengin
29. QTL Biodetection
30. Research International
31. Response Biomedical
32. Roche Applied Science
33. Smiths Detection
34. Tetracore, Inc.
1. 20/20 GeneSystems Inc.
2. Advnt Biotechnologies
3. Agilent Technologies
4. Alexeter Technologies
5. ANP Technologies, Inc.
6. BAS - Biological Alarm Systems Ltd. (Israel)
7. BD Biosciences Immunocytometry Systems
8. Bertin Technologies
9. BioDefense Corporation
10. BioDETECT AS
11. BioSentinel Pharmaceuticals LLC
12. 3M Microbiology (Biotrace International, Ltd.)
13. BioTraces, Inc.
14. BioVeris Corporation
15. Biral
16. Cepheid
17. Commonwealth Biotechnologies, Inc.
18. Dycor Technologies Ltd.
19. Environics Oy
20. Evogen, Inc.
21. General Dynamics Canada
22. GenPrime, Inc.
23. Groton Biosystems
24. Haztech Systems, Inc.
25. Idaho Technology, Inc.
26. JMAR Technologies, Inc.
27. New Horizons Diagnostics
28. Proengin
29. QTL Biodetection
30. Research International
31. Response Biomedical
32. Roche Applied Science
33. Smiths Detection
34. Tetracore, Inc.

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