Flow Cytometry: Products, Technologies and Global Markets

  • October 2013
  • -
  • BCC Research
  • -
  • 130 pages

INTRODUCTION

BCC Research measures and segments the flow cytometry market on the basis of instruments, reagents, software, services, technologies, applications and end users. Key instruments discussed in the report include analyzers, cell sorters, detectors, measuring systems, amplification systems, immunocytometry products, fluidics and optical systems. The market for reagents includes conjugated antibodies, dyes, beads and other consumables. Other markets covered in the report are the related software market, chemistry kits and the flow cytometry services market.

STUDY BACKGROUND

Increasing research and commercialization in various fields of the life sciences, such as proteomics, genomics, pharmacogenomics and stem cell research, have resulted in increased demand for high-throughput technologies such as flow cytometry. The introduction of multicolor flow cytometers with multiple lasers capable of simultaneously detecting up to 18 cell parameters is also having a strong impact on the growth of the market. However, several constraints, such as the high cost of the equipment, are hindering market growth. This report aims to present the issues that are driving and constraining market growth, as well as probable solutions that can address these concerns. The report also highlights key needs of the market such as the importance of reducing the size and cost of flow cytometry equipment. The market forecast of the key market segments will enable the reader to quantitatively assess the flow cytometry market.

STUDY GOALS AND OBJECTIVES

The key objective of the report is to offer a comprehensive analysis of the changing dynamics within the flow cytometry market and the relevant business impact thereof. The report provides intensive analysis with respect to top innovations, key market players and opportunities. Market forecasting forms a very key element of this report, which aims to assist industry participants in making key business decisions. Detailed market segmentation on several different levels provides comprehensive market intelligence. The report also aims to shed light on novel opportunities that can enhance market share for companies involved in flow cytometry.

INTENDED AUDIENCE

The key audience for this study includes:
• R&D directors, CEOs and marketing managers of flow cytometry and allied technology manufacturers and service providers.
• Universities.
• Research centers.
• Consulting firms.

The study will enable the audience to understand the changing market scenario and acceptance levels of the technology. The life sciences industry will utilize the data to understand the benefits and restraints of flow cytometry technologies in working toward greater market penetration.

SCOPE AND FORMAT

New product introductions that have been launched since 2010 are covered. Due to the timing of the writing of this report, the figures for 2013 are estimated except where actual results have been reported.
The key content of the report highlights:
• Key market analysis.
• Strategic recommendations.
• Market dynamics.
• Market estimation for the forecast period of 2010 through 2018.
• Competitive developments.
• Profiles of key market players.
• Patents.

RESEARCH METHODOLOGY AND INFORMATION SOURCES

Both primary and secondary research methodologies were used in preparing this study. Because there is a chain of markets involved in the report, the markets have been assessed via the top-down method. The macro markets have been analyzed and qualitative information was taken into consideration in forecasting the market values of the segments. The historic and base numbers were derived from both primary and secondary sources. These numbers were further distributed to the micro segments and were effectively validated by market players and secondary sources. The other contents of the report were derived from primary research, which included key market participants, key opinion leaders and research institutes. Secondary data was gathered from paid sources, such as Factiva, and OneSource and other free sources such as SEC filings and company websites.

Market figures are based on revenues at the manufacturers’ level. The base year for analysis and projection is 2013. Trends are assessed based on a number of parameters, including projected sales for existing products, new productintroductions and expanded indications for existing products.
This report also includes overviews and forecasts the market for flow cytometry by product, company and geographic region through 2018. The global market is analyzed and data are provided for each segment.

ANALYST CREDENTIALS

Jackson Highsmith is a life sciences research consultant with more than 16 years of experience. Jackson has been consulting with specialty pharmaceuticals and large pharmaceutical industry players since 2007. Prior to that, he worked at a large research consultancy where he focused on in-depth research; he also has worked at a large pharmaceutical company dealing with a wide range of medical therapeutics in early and mid-stage drug development.

REPORT HIGHLIGHTS

This report will provide:
• An overview of the flow cytometry market
• Analyses of global market trends, with data from 2012, estimates for 2013, and projections of compound annual growth rates (CAGRs) through 2018
• Breakdowns of the flow cytometry market into segments such as instruments, reagents, software, services, technologies, applications, and end users
• Discussions of how constraints such as increased equipment costs are hindering market growth
• Comprehensive company profiles of major players.

Table Of Contents

TABLE OF CONTENTS

CHAPTER 1 INTRODUCTION 2

STUDY BACKGROUND 2
STUDY GOALS AND OBJECTIVES 2
INTENDED AUDIENCE 2
SCOPE AND FORMAT 3
RESEARCH METHODOLOGY AND INFORMATION SOURCES 3
ANALYST CREDENTIALS 3
RELATED BCC RESEARCH REPORTS 4
BCC RESEARCH ON-LINE SERVICES 4
DISCLAIMER 4

CHAPTER 2 SUMMARY 6

SUMMARY TABLE GLOBAL MARKET FOR FLOW CYTOMETRY PRODUCTS BY TYPE,
THROUGH 2018 ($ MILLIONS) 6
SUMMARY FIGURE GLOBAL MARKET FOR FLOW CYTOMETRY PRODUCTS BY TYPE,
2010-2018 ($ MILLIONS) 6

CHAPTER 3 MARKET OVERVIEW 9

CURRENT MARKET DYNAMICS 10
OUTLOOK THROUGH FORECAST PERIOD 10
MARKET DRIVERS 11
RECENT CONSOLIDATION WITHIN THE INDUSTRY 11
PRODUCT/TECHNOLOGY INNOVATIONS 11
EMERGING MAINSTREAM ROLE IN DRUG DISCOVERY AND DEVELOPMENT 12
WIDE RANGE OF APPLICATIONS 12
CONTRACT RESEARCH AND CLINICAL TRIAL ORGANIZATIONS 12
EXPECTED FURTHER MandA ACTIVITY WITHIN THE INDUSTRY 13
HIGH COST OF INSTRUMENTS 13
LACK OF AWARENESS 14
REQUIREMENT OF HIGHLY TRAINED PERSONNEL 14
OPPORTUNITIES 14
EVOLUTION OF FLOW CYTOMETRY 15
ANALYSIS OF FLOW CYTOMETRY'S CAPABILITIES 15
FLOW CYTOMETRY IMMUNOPHENOTYPING 17
FIGURE 1 FLOW CYTOMETRY IMMUNOPHENOTYPING VERSUS CONVENTIONAL
MICROSCOPY-BASED IMMUNOPHENOTYPING TECHNIQUES 18
FIGURE 2 DISEASE, DIAGNOSIS AND MANAGEMENT POTENTIAL OF FLOW
CYTOMETRY IMMUNOPHENOTYPING 19
USE OF FLOW CYTOMETRY IN RESOURCE-POOR REGIONS IS GAINING
IMPORTANCE 20
ACQUISITION SUMMARY AND MARKET IMPLICATIONS 20
Danaher Purchase of Beckman Coulter 20
Beckman Coulter Life Sciences Acquires ReaMetrix 21
BD Acquires Accuri Cytometers 21
ANALYSES: KEY PLAYERS, COMPETITORS AND MARKET 22
FIGURE 3 GLOBAL FLOW CYTOMETRY MARKET SHARES BY PRODUCT TYPE, 2013
(%) 23
FIGURE 4 ANALYSIS OF MARKET PLAYERS—STRATEGIES AND DEVELOPMENTS,
2006-2013 23
EMERGING ECONOMIES AND TECHNOLOGY ADOPTION 26
STRATEGIC RECOMMENDATIONS 27
PATENT ANALYSIS 27
FIGURE 5 PATENT ANALYSIS BY TYPE OF PRODUCT, 2011-2012 (%) 28
FIGURE 6 PATENTS BY REGION, 2011-2012 (%) 29

CHAPTER 4 GLOBAL MARKET FOR FLOW CYTOMETRY PRODUCTS 31

TABLE 1 GLOBAL FLOW CYTOMETRY MARKET BY REGION, THROUGH 2018 ($
MILLIONS) 31
MARKET FOR FLOW CYTOMETRY INSTRUMENTS 31
TABLE 2 GLOBAL MARKET FOR FLOW CYTOMETRY INSTRUMENTS, THROUGH 2018
($ MILLIONS) 32
TABLE 3 GLOBAL MARKET FOR FLOW CYTOMETRY INSTRUMENTS BY REGION,
THROUGH 2018 ($ MILLIONS) 32
MARKET DRIVERS 33
TECHNOLOGICAL ADVANCES IN INSTRUMENT COMPONENTS ARE
BOOSTING DEMAND 33
GROWING ADOPTION OF BENCHTOP FLOW CYTOMETERS 33
MARKET RESTRAINTS 34
MAINTENANCE AND SERVICES COSTS 34
CYTOMETRY PLATFORMS 34
TABLE 4 GLOBAL MARKET FOR FLOW CYTOMETRY PLATFORMS, THROUGH 2018 ($
MILLIONS) 35
TABLE 5 GLOBAL MARKET FOR FLOW CYTOMETRY PLATFORMS BY REGION,
THROUGH 2018 ($ MILLIONS) 35
FLOW CYTOMETRY CELL SORTERS 35
TABLE 6 GLOBAL MARKET FOR FLOW CYTOMETRY CELL SORTERS BY REGION,
THROUGH 2018 ($ MILLIONS) 36
FLOW CYTOMETRY ANALYZERS 36
TABLE 7 GLOBAL MARKET FOR FLOW CYTOMETRY ANALYZERS BY REGION,
THROUGH 2018 ($ MILLIONS) 36
REPLACEABLE COMPONENTS 37
TABLE 8 GLOBAL MARKET FOR THE REPLACEABLE COMPONENTS OF FLOW
CYTOMETERS, THROUGH 2018 ($ MILLIONS) 37
TABLE 9 GLOBAL MARKET FOR THE REPLACEABLE COMPONENTS OF FLOW
CYTOMETERS BY REGION, THROUGH 2018 ($ MILLIONS) 37
FILTERS 38
TABLE 10 GLOBAL MARKET FOR REPLACEABLE FILTERS USED IN FLOW
CYTOMETERS BY REGION, THROUGH 2018 ($ MILLIONS) 38
LASERS 38
TABLE 11 GLOBAL MARKET FOR FLOW CYTOMETRY LASERS BY REGION, THROUGH
2018 ($ MILLIONS) 39
DETECTORS 39
TABLE 12 GLOBAL MARKET FOR FLOW CYTOMETRY DETECTORS BY REGION,
THROUGH 2018 ($ MILLIONS) 39
OTHERS 40
TABLE 13 GLOBAL MARKET FOR OTHER REPLACEABLE COMPONENTS OF FLOW
CYTOMETERS BY REGION, THROUGH 2018 ($ MILLIONS) 40
FLOW CYTOMETRY SYSTEMS AND DEVICES 40
TABLE 14 GLOBAL MARKET FOR FLOW CYTOMETRY SYSTEMS AND DEVICES BY
REGION, THROUGH 2018 ($ MILLIONS) 41
MARKET FOR FLOW CYTOMETRY REAGENTS AND CONSUMABLES 41
TABLE 15 GLOBAL MARKET FOR FLOW CYTOMETRY REAGENTS, THROUGH 2018 ($
MILLIONS) 41
TABLE 16 GLOBAL MARKET FOR FLOW CYTOMETRY REAGENTS BY REGION,
THROUGH 2018 ($ MILLIONS) 42
DRIVERS AND CHALLENGES 42
ANTIBODIES 42
TABLE 17 GLOBAL MARKET FOR FLOW CYTOMETRY ANTIBODIES BY REGION,
THROUGH 2018 ($ MILLIONS) 43
DYES AND FLUOROCHROMES 43
TABLE 18 GLOBAL MARKET FOR FLOW CYTOMETRY DYES BY REGION, THROUGH
2018 ($ MILLIONS) 44
BEADS 44
TABLE 19 GLOBAL MARKET FOR FLOW CYTOMETRY BEADS BY REGION, THROUGH
2018 ($ MILLIONS) 45
OTHERS 45
TABLE 20 GLOBAL MARKET FOR OTHER FLOW CYTOMETRY REAGENTS BY REGION,
THROUGH 2018 ($ MILLIONS) 45
SOFTWARE MARKET 45
TABLE 21 GLOBAL MARKET FOR FLOW CYTOMETRY SOFTWARE BY TYPE, THROUGH
2018 ($ MILLIONS) 46
TABLE 22 GLOBAL FLOW CYTOMETRY SOFTWARE MARKET BY REGION, THROUGH
2018 ($ MILLIONS) 46
WITHIN-SYSTEM SOFTWARE 47
TABLE 23 GLOBAL MARKET FOR WITHIN-SYSTEM FLOW CYTOMETRY SOFTWARE BY
REGION, THROUGH 2018 ($ MILLIONS) 47
THIRD-PARTY SOFTWARE 47
TABLE 24 GLOBAL MARKET FOR THIRD-PARTY FLOW CYTOMETRY SOFTWARE BY
REGION, THROUGH 2018 ($ MILLIONS) 48
SERVICES 48
TABLE 25 GLOBAL FLOW CYTOMETRY SERVICE MARKET BY REGION, THROUGH
2018 ($ MILLIONS) 48

CHAPTER 5 GLOBAL MARKET FOR APPLICATIONS OF FLOW CYTOMETRY 51

TABLE 26 GLOBAL FLOW CYTOMETRY MARKET BY APPLICATION, THROUGH 2018 ($
MILLIONS) 51
TABLE 27 GLOBAL MARKET FOR FLOW CYTOMETRY APPLICATIONS BY REGION,
THROUGH 2018 ($ MILLIONS) 52
MARKET DRIVERS 52
GOVERNMENT INITIATIVES AND AVAILABILITY OF RESEARCH FUNDING 52
PRESSING NEED FOR PATIENT AND DISEASE MANAGEMENT 52
EXPANDING END-USER BASE 53
NEED FOR HIGH-THROUGHPUT SCREENING/HIGH-CONTENT SCREENING 53
MARKET RESTRAINTS 54
FLOW CYTOMETRY REQUIRES A HIGH DEGREE OF CLINICAL AND
MANUFACTURING EXPERTISE 54
RESEARCH APPLICATIONS 54
TABLE 28 GLOBAL MARKET FOR FLOW CYTOMETRY IN RESEARCH APPLICATIONS,
THROUGH 2018 ($ MILLIONS) 54
TABLE 29 GLOBAL MARKET FOR FLOW CYTOMETRY IN RESEARCH APPLICATIONS
BY REGION, THROUGH 2018 ($ MILLIONS) 55
CELL CYCLE ANALYSIS AND CELL PROLIFERATION 55
TABLE 30 GLOBAL MARKET FOR THE APPLICATION OF FLOW CYTOMETRY IN CELL
CYCLE ANALYSIS AND CELL PROLIFERATION BY REGION, THROUGH 2018 ($
MILLIONS)
56
APOPTOSIS 56
TABLE 31 GLOBAL MARKET FOR THE APPLICATION OF FLOW CYTOMETRY IN THE
ANALYSIS OF APOPTOSIS BY REGION, THROUGH 2018 ($ MILLIONS) 56
CELL SORTING 57
TABLE 32 GLOBAL MARKET FOR CELL SORTING BY FLOW CYTOMETRY BY REGION,
THROUGH 2018 ($ MILLIONS) 57
TRANSFECTION AND CELL VIABILITY 58
TABLE 33 GLOBAL MARKET FOR THE APPLICATION OF FLOW CYTOMETRY IN
ANALYZING TRANSFECTION AND CELL VIABILITY BY REGION, THROUGH 2018 ($
MILLIONS)
58
OTHERS 58
TABLE 34 GLOBAL MARKET FOR OTHER APPLICATIONS OF FLOW CYTOMETRY BY
REGION, THROUGH 2018 ($ MILLIONS) 59
CLINICAL APPLICATIONS 59
TABLE 35 GLOBAL MARKET FOR CLINICAL APPLICATIONS OF FLOW CYTOMETRY,
THROUGH 2018 ($ MILLIONS) 59
TABLE 36 GLOBAL MARKET FOR CLINICAL APPLICATIONS OF FLOW CYTOMETRY BY
REGION, THROUGH 2018 ($ MILLIONS) 60
ORGAN TRANSPLANTATION 60
TABLE 37 GLOBAL MARKET FOR CLINICAL APPLICATIONS OF FLOW CYTOMETRY IN
ORGAN TRANSPLANTS BY REGION, THROUGH 2018 ($ MILLIONS) 61
HEMATOLOGY 61
TABLE 38 GLOBAL MARKET FOR CLINICAL APPLICATIONS OF FLOW CYTOMETRY IN
HEMATOLOGY BY REGION, THROUGH 2018 ($ MILLIONS) 62
CANCER AND SOLID TUMOR IMMUNOLOGY 62
TABLE 39 GLOBAL MARKET FOR CLINICAL APPLICATIONS OF FLOW CYTOMETRY IN
ONCOLOGY AND TUMOR IMMUNOLOGY BY REGION, THROUGH 2018 ($ MILLIONS) 63
IMMUNODEFICIENCY DISEASE-HIV INFECTION 63
TABLE 40 GLOBAL MARKET FOR THE CLINICAL APPLICATION OF FLOW CYTOMETRY
IN HIV BY REGION, THROUGH 2018 ($ MILLIONS) 64
OTHERS 64
TABLE 41 GLOBAL MARKET FOR "OTHER" CLINICAL APPLICATIONS OF FLOW
CYTOMETRY BY REGION, THROUGH 2018 ($ MILLIONS) 64

CHAPTER 6 GLOBAL MARKET FOR FLOW CYTOMETRY TECHNOLOGY 67

FLOW CYTOMETRY TECHNOLOGY 67
TABLE 42 GLOBAL MARKET FOR FLOW CYTOMETRY BY TECHNOLOGY, THROUGH
2018 ($ MILLIONS) 67
TABLE 43 GLOBAL MARKET FOR FLOW CYTOMETRY TECHNOLOGY BY REGION,
THROUGH 2018 ($ MILLIONS) 68
CELL-BASED FLOW CYTOMETRY 68
TABLE 44 GLOBAL MARKET FOR CELL-BASED FLOW CYTOMETRY BY REGION,
THROUGH 2018 ($ MILLIONS) 69
Drivers 69
Increasing HIV/AIDS Awareness 69
Several Clinical Applications 69
BEAD-BASED FLOW CYTOMETRY 69
TABLE 45 GLOBAL MARKET FOR BEAD-BASED FLOW CYTOMETRY BY REGION,
THROUGH 2018 ($ MILLIONS) 70
Market Drivers 70
Rapid Progress and Increasing Application in Proteomics 70
Application in Genomics 70
Competitive Edge over ELISA Technique and Microarrays 71
Market Restraints 71
Obtaining Quality Data Poses a Challenge 71

CHAPTER 7 FLOW CYTOMETRY END-USER MARKET 74

FLOW CYTOMETRY END-USER MARKET 74
FIGURE 7 GLOBAL MARKET FOR FLOW CYTOMETRY BY TYPE OF END USER, 2013
AND 2018 (%) 74
TABLE 46 GLOBAL MARKET FOR FLOW CYTOMETRY BY TYPE OF END USER,
THROUGH 2018 ($ MILLIONS) 76
TABLE 47 GLOBAL FLOW CYTOMETRY END-USER MARKET BY REGION, THROUGH
2018 ($ MILLIONS) 76
COMMERCIAL ORGANIZATIONS 76
TABLE 48 GLOBAL COMMERCIAL END-USER MARKET FOR FLOW CYTOMETRY BY
REGION, THROUGH 2018 ($ MILLIONS) 77
ACADEMIC INSTITUTIONS 77
TABLE 49 GLOBAL ACADEMIC END-USER MARKET FOR FLOW CYTOMETRY BY
REGION, THROUGH 2018 ($ MILLIONS) 78
HOSPITALS 78
TABLE 50 GLOBAL HOSPITAL END-USER MARKET FOR FLOW CYTOMETRY BY
REGION, THROUGH 2018 ($ MILLIONS) 79
MEDICAL SCHOOLS AND CLINICAL TESTING LABS 79
TABLE 51 GLOBAL MEDICAL SCHOOL/CLINICAL LABORATORY END-USER MARKET
FOR FLOW CYTOMETRY BY REGION, THROUGH 2018 ($ MILLIONS) 79
OTHERS 80
TABLE 52 GLOBAL MARKET FOR "OTHER" END USERS OF FLOW CYTOMETRY BY
REGION, THROUGH 2018 ($ MILLIONS) 80

CHAPTER 8 COMPETITIVE LANDSCAPE 82

FIGURE 8 DEVELOPMENTS IN GLOBAL FLOW CYTOMETRY MARKET, 2010 TO JUNE
2013 (%) 82
RECENT FLOW CYTOMETRY INDUSTRY DEVELOPMENTS 83
ACQUISITIONS 83
PRODUCT LAUNCHES 84
AGREEMENTS/PARTNERSHIPS/COLLABORATIONS 85

CHAPTER 9 GEOGRAPHIC ANALYSIS OF THE GLOBAL FLOW CYTOMETRY MARKET 87

GEOGRAPHIC ANALYSIS 87
FIGURE 9 TOTAL FLOW CYTOMETRY MARKET BY REGION, 2013 AND 2018 (%) 88
UNITED STATES 89
TABLE 53 U.S. FLOW CYTOMETRY MARKET, THROUGH 2018 ($ MILLIONS) 89
EUROPE 89
TABLE 54 EUROPEAN FLOW CYTOMETRY MARKET, THROUGH 2018 ($ MILLIONS) 90
ASIA AND ROW 90
TABLE 55 ASIA AND ROW FLOW CYTOMETRY MARKET, THROUGH 2018 ($
MILLIONS) 91

CHAPTER 10 COMPANY PROFILES 93

ADVANCED ANALYTICAL TECHNOLOGIES INC. 93
TABLE 56 RECENT DEVELOPMENTS—ADVANCED ANALYTICAL TECHNOLOGIES 94
ALPCO DIAGNOSTICS 94
TABLE 57 RECENT DEVELOPMENTS-ALPCO DIAGNOSTICS 95
APOGEE FLOW SYSTEMS 95
APPLIED CYTOMETRY 96
TABLE 58 RECENT DEVELOPMENTS—APPLIED CYTOMETRY 97
BANGS LABORATORY INC. (BLI) 97
TABLE 59 RECENT DEVELOPMENTS—BANGS LABORATORY INC. (BLI) 98
BECKMAN COULTER INC. 98
TABLE 60 RECENT DEVELOPMENTS—BECKMAN COULTER INC. 100
BECTON, DICKINSON AND CO. 101
TABLE 61 RECENT DEVELOPMENTS—BECTON, DICKINSON AND CO. 102
BIOCYTEX 104
BIOLEGEND 104
TABLE 62 RECENT DEVELOPMENTS—BIOLEGEND 105
BIO-RAD/ABD SEROTEC 105
TABLE 63 RECENT DEVELOPMENTS—BIO-RAD/ABD SEROTEC 106
BIOVISION INC. 107
CELL SIGNALING TECHNOLOGY 107
TABLE 64 RECENT DEVELOPMENTS—CELL SIGNALING TECHNOLOGY (CST) 108
CYTEK DEVELOPMENT INC. 109
DAKO DENMARK A/S 110
TABLE 65 RECENT DEVELOPMENTS—DAKO 110
EBIOSCIENCE INC. 111
TABLE 66 RECENT DEVELOPMENTS—EBIOSCIENCE 112
EMD MILLIPORE 113
TABLE 67 RECENT DEVELOPMENTS—EMD MILLIPORE 114
INTELLICYT CORP. 115
TABLE 68 RECENT DEVELOPMENTS-INTELLICYT CORP. 115
LIFE TECHNOLOGIES CORP. 116
TABLE 69 RECENT DEVELOPMENTS—LIFE TECHNOLOGIES CORP. 117
LUMINEX CORP. 118
TABLE 70 RECENT DEVELOPMENTS-LUMINEX CORP. 118
MILTENYI BIOTEC 120
TABLE 71 RECENT DEVELOPMENTS-MILTENYI BIOTEC 121
MORPHOSYS AG 122
TABLE 72 RECENT DEVELOPMENTS—MORPHOSYS 122
PARTEC GMBH 123
POINTCARE TECHNOLOGIES INC. 124
TABLE 73 RECENT DEVELOPMENTS-POINTCARE TECHNOLOGIES INC. 124
PROMEGA CORP. 124
TABLE 74 RECENT DEVELOPMENTS—PROMEGA CORP. 125
RandD SYSTEMS INC. 126
SANTA CRUZ BIOTECHNOLOGY INC. 127
SIGMA-ALDRICH CORP. 127
TABLE 75 RECENT DEVELOPMENTS-SIGMA-ALDRICH CORP. 128
SOUTHERN BIOTECH 130
UNION BIOMETRICA INC. 130

CHAPTER 11 APPENDIX LIST OF PATENTS 133

TABLE 76 U.S. PATENTS AND PATENT APPLICATIONS 133
TABLE 77 EUROPEAN PATENTS 138
TABLE 78 JAPANESE PATENTS 140



LIST OF TABLES

SUMMARY TABLE GLOBAL MARKET FOR FLOW CYTOMETRY PRODUCTS BY TYPE,
THROUGH 2018 ($ MILLIONS) 6
TABLE 1 GLOBAL FLOW CYTOMETRY MARKET BY REGION, THROUGH 2018 ($
MILLIONS) 31
TABLE 2 GLOBAL MARKET FOR FLOW CYTOMETRY INSTRUMENTS, THROUGH 2018 ($
MILLIONS) 32
TABLE 3 GLOBAL MARKET FOR FLOW CYTOMETRY INSTRUMENTS BY REGION,
THROUGH 2018 ($ MILLIONS) 32
TABLE 4 GLOBAL MARKET FOR FLOW CYTOMETRY PLATFORMS, THROUGH 2018 ($
MILLIONS) 35
TABLE 5 GLOBAL MARKET FOR FLOW CYTOMETRY PLATFORMS BY REGION,
THROUGH 2018 ($ MILLIONS) 35
TABLE 6 GLOBAL MARKET FOR FLOW CYTOMETRY CELL SORTERS BY REGION,
THROUGH 2018 ($ MILLIONS) 36
TABLE 7 GLOBAL MARKET FOR FLOW CYTOMETRY ANALYZERS BY REGION,
THROUGH 2018 ($ MILLIONS) 36
TABLE 8 GLOBAL MARKET FOR THE REPLACEABLE COMPONENTS OF FLOW
CYTOMETERS, THROUGH 2018 ($ MILLIONS) 37
TABLE 9 GLOBAL MARKET FOR THE REPLACEABLE COMPONENTS OF FLOW
CYTOMETERS BY REGION, THROUGH 2018 ($ MILLIONS) 37
TABLE 10 GLOBAL MARKET FOR REPLACEABLE FILTERS USED IN FLOW CYTOMETERS
BY REGION, THROUGH 2018 ($ MILLIONS) 38
TABLE 11 GLOBAL MARKET FOR FLOW CYTOMETRY LASERS BY REGION, THROUGH
2018 ($ MILLIONS) 39
TABLE 12 GLOBAL MARKET FOR FLOW CYTOMETRY DETECTORS BY REGION,
THROUGH 2018 ($ MILLIONS) 39
TABLE 13 GLOBAL MARKET FOR OTHER REPLACEABLE COMPONENTS OF FLOW
CYTOMETERS BY REGION, THROUGH 2018 ($ MILLIONS) 40
TABLE 14 GLOBAL MARKET FOR FLOW CYTOMETRY SYSTEMS AND DEVICES BY
REGION, THROUGH 2018 ($ MILLIONS) 41
TABLE 15 GLOBAL MARKET FOR FLOW CYTOMETRY REAGENTS, THROUGH 2018 ($
MILLIONS) 41
TABLE 16 GLOBAL MARKET FOR FLOW CYTOMETRY REAGENTS BY REGION,
THROUGH 2018 ($ MILLIONS) 42
TABLE 17 GLOBAL MARKET FOR FLOW CYTOMETRY ANTIBODIES BY REGION,
THROUGH 2018 ($ MILLIONS) 43
TABLE 18 GLOBAL MARKET FOR FLOW CYTOMETRY DYES BY REGION, THROUGH
2018 ($ MILLIONS) 44
TABLE 19 GLOBAL MARKET FOR FLOW CYTOMETRY BEADS BY REGION, THROUGH
2018 ($ MILLIONS) 45
TABLE 20 GLOBAL MARKET FOR OTHER FLOW CYTOMETRY REAGENTS BY REGION,
THROUGH 2018 ($ MILLIONS) 45
TABLE 21 GLOBAL MARKET FOR FLOW CYTOMETRY SOFTWARE BY TYPE, THROUGH
2018 ($ MILLIONS) 46
TABLE 22 GLOBAL FLOW CYTOMETRY SOFTWARE MARKET BY REGION, THROUGH
2018 ($ MILLIONS) 46
TABLE 23 GLOBAL MARKET FOR WITHIN-SYSTEM FLOW CYTOMETRY SOFTWARE BY
REGION, THROUGH 2018 ($ MILLIONS) 47
TABLE 24 GLOBAL MARKET FOR THIRD-PARTY FLOW CYTOMETRY SOFTWARE BY
REGION, THROUGH 2018 ($ MILLIONS) 48
TABLE 25 GLOBAL FLOW CYTOMETRY SERVICE MARKET BY REGION, THROUGH 2018
($ MILLIONS) 48
TABLE 26 GLOBAL FLOW CYTOMETRY MARKET BY APPLICATION, THROUGH 2018 ($
MILLIONS) 51
TABLE 27 GLOBAL MARKET FOR FLOW CYTOMETRY APPLICATIONS BY REGION,
THROUGH 2018 ($ MILLIONS) 52
TABLE 28 GLOBAL MARKET FOR FLOW CYTOMETRY IN RESEARCH APPLICATIONS,
THROUGH 2018 ($ MILLIONS) 54
TABLE 29 GLOBAL MARKET FOR FLOW CYTOMETRY IN RESEARCH APPLICATIONS BY
REGION, THROUGH 2018 ($ MILLIONS) 55
TABLE 30 GLOBAL MARKET FOR THE APPLICATION OF FLOW CYTOMETRY IN CELL
CYCLE ANALYSIS AND CELL PROLIFERATION BY REGION, THROUGH 2018 ($
MILLIONS)
56
TABLE 31 GLOBAL MARKET FOR THE APPLICATION OF FLOW CYTOMETRY IN THE
ANALYSIS OF APOPTOSIS BY REGION, THROUGH 2018 ($ MILLIONS) 56
TABLE 32 GLOBAL MARKET FOR CELL SORTING BY FLOW CYTOMETRY BY REGION,
THROUGH 2018 ($ MILLIONS) 57
TABLE 33 GLOBAL MARKET FOR THE APPLICATION OF FLOW CYTOMETRY IN
ANALYZING TRANSFECTION AND CELL VIABILITY BY REGION, THROUGH 2018 ($
MILLIONS)
58
TABLE 34 GLOBAL MARKET FOR OTHER APPLICATIONS OF FLOW CYTOMETRY BY
REGION, THROUGH 2018 ($ MILLIONS) 59
TABLE 35 GLOBAL MARKET FOR CLINICAL APPLICATIONS OF FLOW CYTOMETRY,
THROUGH 2018 ($ MILLIONS) 59
TABLE 36 GLOBAL MARKET FOR CLINICAL APPLICATIONS OF FLOW CYTOMETRY BY
REGION, THROUGH 2018 ($ MILLIONS) 60
TABLE 37 GLOBAL MARKET FOR CLINICAL APPLICATIONS OF FLOW CYTOMETRY IN
ORGAN TRANSPLANTS BY REGION, THROUGH 2018 ($ MILLIONS) 61
TABLE 38 GLOBAL MARKET FOR CLINICAL APPLICATIONS OF FLOW CYTOMETRY IN
HEMATOLOGY BY REGION, THROUGH 2018 ($ MILLIONS) 62
TABLE 39 GLOBAL MARKET FOR CLINICAL APPLICATIONS OF FLOW CYTOMETRY IN
ONCOLOGY AND TUMOR IMMUNOLOGY BY REGION, THROUGH 2018 ($ MILLIONS) 63
TABLE 40 GLOBAL MARKET FOR THE CLINICAL APPLICATION OF FLOW CYTOMETRY
IN HIV BY REGION, THROUGH 2018 ($ MILLIONS) 64
TABLE 41 GLOBAL MARKET FOR "OTHER" CLINICAL APPLICATIONS OF FLOW
CYTOMETRY BY REGION, THROUGH 2018 ($ MILLIONS) 64
TABLE 42 GLOBAL MARKET FOR FLOW CYTOMETRY BY TECHNOLOGY, THROUGH
2018 ($ MILLIONS) 67
TABLE 43 GLOBAL MARKET FOR FLOW CYTOMETRY TECHNOLOGY BY REGION,
THROUGH 2018 ($ MILLIONS) 68
TABLE 44 GLOBAL MARKET FOR CELL-BASED FLOW CYTOMETRY BY REGION,
THROUGH 2018 ($ MILLIONS) 69
TABLE 45 GLOBAL MARKET FOR BEAD-BASED FLOW CYTOMETRY BY REGION,
THROUGH 2018 ($ MILLIONS) 70
TABLE 46 GLOBAL MARKET FOR FLOW CYTOMETRY BY TYPE OF END USER,
THROUGH 2018 ($ MILLIONS) 76
TABLE 47 GLOBAL FLOW CYTOMETRY END-USER MARKET BY REGION, THROUGH
2018 ($ MILLIONS) 76
TABLE 48 GLOBAL COMMERCIAL END-USER MARKET FOR FLOW CYTOMETRY BY
REGION, THROUGH 2018 ($ MILLIONS) 77
TABLE 49 GLOBAL ACADEMIC END-USER MARKET FOR FLOW CYTOMETRY BY
REGION, THROUGH 2018 ($ MILLIONS) 78
TABLE 50 GLOBAL HOSPITAL END-USER MARKET FOR FLOW CYTOMETRY BY REGION,
THROUGH 2018 ($ MILLIONS) 79
TABLE 51 GLOBAL MEDICAL SCHOOL/CLINICAL LABORATORY END-USER MARKET
FOR FLOW CYTOMETRY BY REGION, THROUGH 2018 ($ MILLIONS) 79
TABLE 52 GLOBAL MARKET FOR "OTHER" END USERS OF FLOW CYTOMETRY BY
REGION, THROUGH 2018 ($ MILLIONS) 80
TABLE 53 U.S. FLOW CYTOMETRY MARKET, THROUGH 2018 ($ MILLIONS) 89
TABLE 54 EUROPEAN FLOW CYTOMETRY MARKET, THROUGH 2018 ($ MILLIONS) 90
TABLE 55 ASIA AND ROW FLOW CYTOMETRY MARKET, THROUGH 2018 ($ MILLIONS) 91
TABLE 56 RECENT DEVELOPMENTS—ADVANCED ANALYTICAL TECHNOLOGIES 94
TABLE 57 RECENT DEVELOPMENTS-ALPCO DIAGNOSTICS 95
TABLE 58 RECENT DEVELOPMENTS—APPLIED CYTOMETRY 97
TABLE 59 RECENT DEVELOPMENTS—BANGS LABORATORY INC. (BLI) 98
TABLE 60 RECENT DEVELOPMENTS—BECKMAN COULTER INC. 100
TABLE 61 RECENT DEVELOPMENTS—BECTON, DICKINSON AND CO. 102
TABLE 62 RECENT DEVELOPMENTS—BIOLEGEND 105
TABLE 63 RECENT DEVELOPMENTS—BIO-RAD/ABD SEROTEC 106
TABLE 64 RECENT DEVELOPMENTS—CELL SIGNALING TECHNOLOGY (CST) 108
TABLE 65 RECENT DEVELOPMENTS—DAKO 110
TABLE 66 RECENT DEVELOPMENTS—EBIOSCIENCE 112
TABLE 67 RECENT DEVELOPMENTS—EMD MILLIPORE 114
TABLE 68 RECENT DEVELOPMENTS-INTELLICYT CORP. 115
TABLE 69 RECENT DEVELOPMENTS—LIFE TECHNOLOGIES CORP. 117
TABLE 70 RECENT DEVELOPMENTS-LUMINEX CORP. 118
TABLE 71 RECENT DEVELOPMENTS-MILTENYI BIOTEC 121
TABLE 72 RECENT DEVELOPMENTS—MORPHOSYS 122
TABLE 73 RECENT DEVELOPMENTS-POINTCARE TECHNOLOGIES INC. 124
TABLE 74 RECENT DEVELOPMENTS—PROMEGA CORP. 125
TABLE 75 RECENT DEVELOPMENTS-SIGMA-ALDRICH CORP. 128
TABLE 76 U.S. PATENTS AND PATENT APPLICATIONS 133
TABLE 77 EUROPEAN PATENTS 138
TABLE 78 JAPANESE PATENTS 140



LIST OF FIGURES

SUMMARY FIGURE GLOBAL MARKET FOR FLOW CYTOMETRY PRODUCTS BY TYPE,
2010-2018 ($ MILLIONS) 6
FIGURE 1 FLOW CYTOMETRY IMMUNOPHENOTYPING VERSUS CONVENTIONAL
MICROSCOPY-BASED IMMUNOPHENOTYPING TECHNIQUES 18
FIGURE 2 DISEASE, DIAGNOSIS AND MANAGEMENT POTENTIAL OF FLOW
CYTOMETRY IMMUNOPHENOTYPING 19
FIGURE 3 GLOBAL FLOW CYTOMETRY MARKET SHARES BY PRODUCT TYPE, 2013 (%) 23
FIGURE 4 ANALYSIS OF MARKET PLAYERS—STRATEGIES AND DEVELOPMENTS,
2006-2013 23
FIGURE 5 PATENT ANALYSIS BY TYPE OF PRODUCT, 2011-2012 (%) 28
FIGURE 6 PATENTS BY REGION, 2011-2012 (%) 29
FIGURE 7 GLOBAL MARKET FOR FLOW CYTOMETRY BY TYPE OF END USER, 2013
AND 2018 (%) 74
FIGURE 8 DEVELOPMENTS IN GLOBAL FLOW CYTOMETRY MARKET, 2010 TO JUNE
2013 (%) 82
FIGURE 9 TOTAL FLOW CYTOMETRY MARKET BY REGION, 2013 AND 2018 (%) 88

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