Sustained Release Injectables: Evolving Formulations, Improving Dosing Regimens

• Publication date: March 2011

The ability to formulate injectable drugs to increase the duration of efficacy for a given dose and simultaneously reduce the dosing frequency addresses several important health care issues. Less frequent dosing is believed to improve patient safety, reduce the incidence of injection site complications and improve compliance with drug protocols. Sustained release formulations mitigate the bolus effect at the time of injection, and thus have a sal...

The ability to formulate injectable drugs to increase the duration of efficacy for a given dose and simultaneously reduce the dosing frequency addresses several important health care issues. Less frequent dosing is believed to improve patient safety, reduce the incidence of injection site complications and improve compliance with drug protocols. Sustained release formulations mitigate the bolus effect at the time of injection, and thus have a salutary influence on drug side effects. All of these advantages, along with the need for fewer patient caregiver visits (for practitioner-administered drugs) have a positive, downward impact on overall healthcare costs. Currently approved sustained release injectables rely on a spectrum of branded formulation technologies to modulate the drug’s release profile post-injection. Typically off-patent or generic drugs, they include drug therapies for almost a dozen major therapeutic segments, including neurological conditions, metabolic diseases, oncology, pain management and reproductive health. As the incidence and prevalence of chronic illnesses increases with the aging population, the attraction and interest in sustained release injectables will increase.

Highlights

• Provides detailed analysis of sustained release injectable products, market segments, market dynamics and market demographics
• Analyzes therapeutic demand drivers and evaluates commercial sustained release injectables in eleven major therapeutic segments
• Charts sustained release product data and market share, and provides forecasts to 2015
• Profiles sustained release technology participants, their product development activities, business strategies, and corporate alliances and affiliations

Drug And Medication Industry

Executive Summary

Injectable Drug Market Dynamics

The Trend toward Self-Administration
Shifting Demographics
Injectable Drug Formulation Technology
Innovation in Injectable Device Designs
Therapeutic Demand Drivers
Competitive Landscape
Risk Factors

Sustained Release Injectables - Branded Formulation Technologies

Biodegradable Polymers
PEG
PLG/PLA/PLGA
Polyether ester
Other Polymers
ChroniJect
CriticalMix
Depofoam
LinkeRx
Liposomes
Medisorb
Medusa
Optisomes
OxtoDEX
SABER/SAIB
Sucrose acetate isobutyrate
SynBiosys
Supercritical Fluid

Analysis of FDA Approved Sustained Release Injectables

cytarabine
goserelin acetate
Interferon
lanreotide acetate
leuprolide acetate
morphine
naltrexone
olanzapine
octreotide acetate
risperidone
paliperidone palmitate
somatostatin
triptorelin pamoate


Development-Stage SR Injectable Drug Candidate Assessment

Addiction
Antivirals
Hormones
Immune Modulators
Incretin Mimetics
Local Anesthetics
Opioid Antagonists
Psychotropics
Antineoplastics


SR Injectables – Therapeutic Sector Impact Analysis & Forecasts

Addiction
Autoimmune Diseases
Diabetes
Infectious Disease
Macular Degeneration
Metabolic Diseases
Neurology
Oncology
Pain Management
Reproductive Health


Sustained Release Injectables – Company Profiles