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This BCC Research report explores the current and future PCR product market, which includes instruments, reagents and consumables, and software and services. It also looks at innovations, market drivers and forces holding back the market. Market forecast provided from 2016 through 2021.

Use this report to:

Analyze the current and future PCR product market in terms of instruments, reagents and consumables, software and services.
Explore the global market of PCR products and for an updated review of the technology’s basic design and its applications in the arenas of biomedical and life science research.
Identify the strengths and weaknesses of many PCR companies in light of new technologies, growing competition and changing customer needs.
Study the innovations, market drivers and forces holding back the PCR product market

Highlights

The global PCR product market should reach $9.8 billion by 2021 from $7.9 billion in 2016 at a compound annual growth rate (CAGR) of 4.4% from 2016 to 2021.
The U.S. PCR product market should reach $4.5 billion by 2021 from $3.4 billion in 2016, at a CAGR of 5.7% from 2016 to 2021.
The European product market should reach $2.7 billion by 2021 from $2.4 billion in 2016, at a CAGR of 2.9% from 2016 to 2021.

Introduction & Scope

Polymerase chain reaction (PCR) allows DNA sequencing as well as the production of millions of copies of a specific DNA sequence within minutes. PCR technology has help make molecular diagnosis to be easier and faster and as a result is used frequently in the diagnosis of disease, in the identification of bacteria and viruses, and in the linking of criminals to crime scenes. BCC Research’s goal in conducting this study is to provide an overview of the current and future global market for PCR products. This report explores the current and future PCR product market, which includes instruments, reagents and consumables, software and services. The report looks at innovations, market drivers and forces holding back the market. In this analysis of the PCR product industry, revenues are broken down by region and sales figures are estimated for the five-year period from 2016 through 2021. Applications and technologies of various PCR products are also discussed. The report also covers significant patents related to PCR technology.

REASONS FOR DOING THIS STUDY

PCR technologies are widely used in many areas, including R&D, clinical domain and other applications. DNA cloning and sequencing, gene expression, genotyping, forensic science, bioinformatics, disease diagnosis, tissue typing, and blood screening are some of the domains where PCR techniques are frequently used. PCR has become a popular clinical molecular diagnostic method due to its ability to make early diagnoses, because it takes less time to perform the test and generate the result. PCR companies’ acquisition strategies and collaborations are also covered in this report. This study also discusses the strengths and weaknesses of many PCR companies in light of new technologies, growing competition and changing customer needs.

SCOPE OF THE STUDY

This report focuses on the global market of PCR products and provides an updated review of the technology’s basic design and its applications in the arenas of biomedical and life science research. The report covers the total market for PCR products, which includes instruments, reagents, consumables and accessories, software and services. The applications included are research applications, clinical applications and other applications (detection of pathogens like fungus and parasites in animals and plants). These categories are further subdivided into types, i.e., types of instruments. The report also covers the market of PCR products by technology, which includes thermal cyclers, real-time PCR, reverse transcriptase (RT) PCR, inverse and standard PCR, assembly and nested PCR, hot start and touchdown PCR, multiplex and other PCR. The reagent market includes individual reagents (such as buffers, dNTPs, controls templates, enzymes, primers and probes), master mixes and kits and other reagents such as PCR calibration kits and PCR cleanup kits. The consumables market includes plates and frames, PCR tubes, PCR sealers and plastics. The PCR software market includes primer design and sequencing software, PCR analyzer software, integrated software and others.

The scope of the study is global. BCC analyzes each market and its application, regulatory environment, new products and advancements, market projections and market shares. The geographical regions covered in the report are the U.S., Europe and emerging markets. The emerging market region covers countries such as India, China, Japan, Korea, Taiwan, Africa, Australia, New Zealand, Canada, etc. Also included in the report are relevant patent analysis and profiles of leading PCR companies. The key players in this market are Thermo Fisher Scientific Inc., Agilent Technologies, Bio-Rad Laboratories Inc., Becton Dickinson & Co., Merck KGaA (Sigma Aldrich), Affymetrix Inc., F. Hoffmann-La Roche Ltd. and Qiagen N.V.

Table Of Contents

Polymerase Chain Reaction (PCR) Technologies and Global Markets
STUDY GOALS AND OBJECTIVES 2
REASONS FOR DOING THIS STUDY 2
INTENDED AUDIENCE 2
SCOPE OF THE STUDY 2
METHODOLOGY 3
INFORMATION SOURCES 3
ANALYSTS' CREDENTIALS 3
RELATED BCC RESEARCH REPORTS 4
BCC RESEARCH WEBSITE 4
DISCLAIMER 5
CHAPTER 2 EXECUTIVE SUMMARY 7
SUMMARY TABLE GLOBAL MARKET FOR PCR PRODUCTS BY REGION, THROUGH
2021 ($ MILLIONS) 8
SUMMARY FIGURE 8
CHAPTER 3 OVERVIEW 10
POLYMERASE CHAIN REACTION 10
EVOLUTION OF PCR 10
TABLE 1 EVOLUTION OF PCR TECHNOLOGY 11
PRINCIPLES OF PCR 11
INSTRUMENTS AND COMPONENTS OF PCR 12
INSTRUMENTS 12
TARGET DNA 12
PRIMERS 12
ENZYME AND ENZYME CONCENTRATION 13
BUFFERS 13
MAGNESIUM CONCENTRATION 13
DEOXYRIBONUCLEOSIDE TRIPHOSPHATES 13
TYPES OF PCR 13
REVERSE TRANSCRIPTION PCR 14
NESTED PCR 14
HOT START AND TOUCHDOWN PCR 15
INVERSE PCR 15
MULTIPLEX PCR 15
QUANTITATIVE PCR 15
TRADITIONAL PCR VS. REAL-TIME PCR 16
TABLE 2 TRADITIONAL VS. REAL-TIME PCR 16
DESIGN OF PRIMER FOR PCR 17
PRIMER SELECTION 17
PRIMER LENGTH 17
MELTING TEMPERATURE 17
SPECIFICITY 18
G/C CONTENT AND POLYPYRIMIDINE (T, C) OR POLYPURINE (A, G)
STRETCHES 18
3' END SEQUENCE 18
PCR QUANTIFICATION METHODS 18
ABSOLUTE QUANTIFICATION 18
Standard Curve Method 18
Digital PCR 19
RELATIVE QUANTIFICATION 19
COMPONENTS OF QUANTITATIVE PCR 19
DNA BINDING DYES 20
TABLE 3 ADVANTAGES AND DISADVANTAGES OF DYE-BASED DETECTION 20
PROBES IN QPCR 20
Linear Probes 21
Structured Probes 21
Molecular Beacon Probes 21
Scorpion Probes 21
CONTROLS FOR QUANTITATIVE PCR EXPERIMENTS 22
APPLICATIONS OF PCR 22
TABLE 4 KEY APPLICATIONS OF PCR TECHNOLOGY 23
THE HUMAN GENOME PROJECT AND PCR 23
CHAPTER 4 REGULATORY APPROVALS 25
GENERAL CONTROLS 25
SPECIAL CONTROLS 25
PREMARKET APPROVAL 25
TABLE 5 NEW APPROVALS OF PCR DEVICES AND KITS BY PREMARKET APPROVAL,
2013- JANUARY 2016 26
NEW APPROVALS OF PCR MACHINES AND KITS BY 510(K) CLEARANCES FROM
2013- JANUARY 2016 27
TABLE 6 NEW APPROVALS OF PCR DEVICES AND KITS BY 510(K) CLEARANCES,
2013- JANUARY 2016 27
RECALLS 31
TABLE 7 RECALLS OF DEVICES, FROM 2013 TO JANUARY 2016 31
CHAPTER 5 NEW DEVELOPMENTS 34
NEW PRODUCT LAUNCHES 34
TABLE 8 NEW PCR PRODUCTS FROM TOP MANUFACTURERS, 2013-JANUARY 2016 34
ALTERNATIVE TECHNOLOGIES TO PCR-BASED ANALYTICAL METHODS 37
LAMP 37
MAP 38
NASBA 38
TMA 39
MERGERS AND ACQUISITIONS 39
TABLE 9 MERGERS AND ACQUISITIONS OF TOP PCR COMPANIES, 2013-JANUARY
2016 39
CHAPTER 6 MARKET ANALYSIS 42
MARKET BY PRODUCT TYPE 42
MARKET OVERVIEW 42
MARKET REVENUE 43
TABLE 10 GLOBAL MARKET FOR PCR PRODUCTS BY TYPE, THROUGH 2021 ($
MILLIONS) 44
FIGURE 1 GLOBAL MARKET FOR PCR PRODUCTS BY TYPE, 2014-2021 ($ MILLIONS) 44
MARKET SHARE 44
TABLE 11 GLOBAL MARKET SHARE OF PCR PRODUCTS BY TYPE, 2015 (%) 44
FIGURE 2 GLOBAL MARKET SHARE OF PCR PRODUCTS BY TYPE, 2015 (%) 45
INSTRUMENT MARKET BY TYPE AND REGION 45
Market Overview 46
Market Revenue by Type 46
TABLE 12 GLOBAL MARKET FOR PCR INSTRUMENTS BY TYPE, THROUGH 2021 ($
MILLIONS) 47
FIGURE 3 GLOBAL MARKET FOR PCR INSTRUMENTS BY TYPE, 2014-2021 ($
MILLIONS) 47
Market Revenue by Region 47
TABLE 13 GLOBAL MARKET FOR PCR INSTRUMENTS BY REGION,THROUGH 2021 ($
MILLIONS) 48
FIGURE 4 GLOBAL MARKET FOR PCR INSTRUMENTS BY REGION, 2014-2021 ($
MILLIONS) 48
Thermal Cyclers 48
Market Overview 48
Market Revenue 49
TABLE 14 GLOBAL MARKET FOR THERMAL CYCLERS BY REGION, THROUGH 2021 ($
MILLIONS) 49
FIGURE 5 GLOBAL MARKET FOR THERMAL CYCLERS BY REGION, 2014-2021 ($
MILLIONS) 49
Real-time PCR Instruments 50
Market Overview 50
Market Revenue 51
TABLE 15 GLOBAL MARKET FOR REAL-TIME PCR INSTRUMENTS BY REGION,
THROUGH 2021 ($ MILLIONS) 51
FIGURE 6 GLOBAL MARKET FOR REAL-TIME PCR INSTRUMENTS BY REGION,
2014-2021 ($ MILLIONS) 51
MARKET FOR REAGENTS AND CONSUMABLES BY TYPE AND REGION 52
Market Overview 52
Market Revenue by Type 53
TABLE 16 GLOBAL MARKET FOR PCR REAGENTS AND CONSUMABLES BY TYPE,
THROUGH 2021 ($ MILLIONS) 54
FIGURE 7 GLOBAL MARKET FOR PCR REAGENTS AND CONSUMABLES BY TYPE,
2014-2021 ($ MILLIONS) 54
Market Revenue by Region 54
TABLE 17 GLOBAL MARKET FOR PCR REAGENTS AND CONSUMABLES BY REGION,
THROUGH 2021 ($ MILLIONS) 55
FIGURE 8 GLOBAL MARKET FOR PCR REAGENTS AND CONSUMABLES BY REGION,
2014-2021 ($ MILLIONS) 55
Individual Reagents 56
Market Overview 57
Market Revenue by Type 57
TABLE 18 GLOBAL MARKET FOR PCR INDIVIDUAL REAGENTS BY TYPE, THROUGH
2021 ($ MILLIONS) 58
FIGURE 9 GLOBAL MARKET FOR PCR INDIVIDUAL REAGENTS BY TYPE, 2014-2021
($ MILLIONS) 58
Market Revenue by Region 59
TABLE 19 GLOBAL MARKET FOR PCR INDIVIDUAL REAGENTS BY REGION, THROUGH
2021 ($ MILLIONS) 59
FIGURE 10 GLOBAL MARKET FOR PCR INDIVIDUAL REAGENTS BY REGION,
2014-2021 ($ MILLIONS) 59
Master Mixes and Reagent Kits 60
Market Overview 60
Market Revenue 61
TABLE 20 GLOBAL MARKET FOR PCR MASTER MIXES/ REAGENT KITS BY REGION,
THROUGH 2021 ($ MILLIONS) 61
FIGURE 11 GLOBAL MARKET FOR PCR MASTER MIXES/REAGENT KITS BY REGION,
2014-2021 ($ MILLIONS) 61
Other Reagents 62
Market Overview 62
Market Revenue 62
TABLE 21 GLOBAL MARKET FOR OTHER REAGENTS BY REGION, THROUGH 2021 ($
MILLIONS) 63
FIGURE 12 GLOBAL MARKET FOR OTHER REAGENTS BY REGION, 2014-2021 ($
MILLIONS) 63
Consumables 63
Market Overview 64
Market Revenue 64
TABLE 22 GLOBAL MARKET FOR CONSUMABLES BY REGION, THROUGH 2021 ($
MILLIONS) 64
FIGURE 13 GLOBAL MARKET FOR CONSUMABLES BY REGION, 2014-2021 ($
MILLIONS) 64
PCR SOFTWARE MARKET BY TYPE AND REGION 65
Market Overview 65
Market Revenue by Type 66
TABLE 23 GLOBAL MARKET FOR PCR SOFTWARE BY TYPE, THROUGH 2021 ($
MILLIONS) 66
FIGURE 14 GLOBAL MARKET FOR PCR SOFTWARE BY TYPE, 2014-2021 ($ MILLIONS) 66
Market Revenue by Region 67
TABLE 24 GLOBAL MARKET FOR PCR SOFTWARE BY REGION, THROUGH 2021 ($
MILLIONS) 67
FIGURE 15 GLOBAL MARKET FOR PCR SOFTWARE BY REGION, 2014-2021 ($
MILLIONS) 68
Primer Design and Sequencing Software 68
Market Overview 68
Market Revenue 69
TABLE 25 GLOBAL MARKET FOR PRIMER DESIGN AND SEQUENCING SOFTWARE BY
REGION, THROUGH 2021 ($ MILLIONS) 69
FIGURE 16 GLOBAL MARKET FOR PRIMER DESIGN AND SEQUENCING SOFTWARE
BY REGION, 2014-2021 ($ MILLIONS) 69
PCR Analyzer Software 70
Market Overview 70
Market Revenue 70
TABLE 26 GLOBAL MARKET FOR PCR ANALYZER SOFTWARE BY REGION, THROUGH
2021 ($ MILLIONS) 71
FIGURE 17 GLOBAL MARKET FOR PCR ANALYZER SOFTWARE BY REGION,
2014-2021 ($ MILLIONS) 71
Other Software Markets 71
Market Overview 72
Market Revenue 72
TABLE 27 GLOBAL MARKET FOR OTHER SOFTWARE BY REGION, THROUGH 2021 ($
MILLIONS) 72
FIGURE 18 GLOBAL MARKET FOR OTHER SOFTWARE BY REGION, 2014-2021 ($
MILLIONS) 73
SERVICES MARKET 73
Market Overview 73
Market Revenue 74
TABLE 28 GLOBAL MARKET FOR PCR SERVICES BY REGION, THROUGH 2021 ($
MILLIONS) 74
FIGURE 19 GLOBAL MARKET FOR PCR SERVICES BY REGION, 2014-2021 ($
MILLIONS) 74
CHAPTER 7 INDUSTRY STRUCTURE 76
PCR INSTRUMENTS 76
MARKET LEADERS 76
TABLE 29 LEADING MANUFACTURERS/SUPPLIERS OF PCR INSTRUMENTS, 2015 76
MARKET SHARE 77
TABLE 30 GLOBAL MARKET SHARE OF MANUFACTURERS/SUPPLIERS OF PCR
INSTRUMENTS, 2015 (%) 77
FIGURE 20 GLOBAL MARKET SHARE OF MANUFACTURERS/SUPPLIERS OF PCR
INSTRUMENTS, 2015 (%) 77
REAGENTS AND CONSUMABLES 78
MARKET LEADERS 78
TABLE 31 LEADING MANUFACTURERS/SUPPLIERS OF PCR REAGENTS AND
CONSUMABLES, 2015 78
MARKET SHARE 81
TABLE 32 GLOBAL MARKET SHARE OF MANUFACTURERS/SUPPLIERS OF PCR
REAGENTS AND CONSUMABLES, 2015 (%) 81
FIGURE 21 GLOBAL MARKET SHARE OF MANUFACTURERS/SUPPLIERS OF PCR
REAGENTS AND CONSUMABLES, 2015 (%) 82
PCR SOFTWARE 82
MARKET LEADERS 82
TABLE 33 LEADING MANUFACTURERS/SUPPLIERS OF PCR SOFTWARE, 2015 83
MARKET SHARE 83
TABLE 34 GLOBAL MARKET SHARE OF MANUFACTURERS/SUPPLIERS OF PCR
SOFTWARE, 2015 (%) 84
FIGURE 22 GLOBAL MARKET SHARE OF MANUFACTURERS/SUPPLIERS OF PCR
SOFTWARE, 2015 (%) 84
CHAPTER 8 MARKET BY APPLICATION AND TECHNOLOGY 86
MARKET BY TECHNOLOGY 86
MARKET OVERVIEW 86
MARKET REVENUE 87
TABLE 35 GLOBAL MARKET FOR PCR TECHNOLOGY BY TYPE, THROUGH 2021 ($
MILLIONS) 88
FIGURE 23 GLOBAL MARKET FOR PCR TECHNOLOGY BY TYPE, 2014-2021 ($
MILLIONS) 88
MARKET SHARE 88
TABLE 36 GLOBAL MARKET SHARE OF PCR TECHNOLOGY BY TYPE, 2015 (%) 88
FIGURE 24 GLOBAL MARKET SHARE OF PCR TECHNOLOGY BY TYPE, 2015 (%) 89
REAL-TIME PCR 89
Market Overview 90
Market Revenue 90
TABLE 37 GLOBAL MARKET FOR REAL-TIME PCR TECHNOLOGY BY REGION,
THROUGH 2021 ($ MILLIONS) 91
FIGURE 25 GLOBAL MARKET FOR REAL-TIME PCR TECHNOLOGY BY REGION,
2014-2021 ($ MILLIONS) 91
REVERSE TRANSCRIPTASE PCR 91
Market Overview 92
Market Revenue 92
TABLE 38 GLOBAL MARKET FOR REVERSE TRANSCRIPTASE PCR TECHNOLOGY BY
REGION, THROUGH 2021 ($ MILLIONS) 92
FIGURE 26 GLOBAL MARKET FOR REVERSE TRANSCRIPTASE PCR TECHNOLOGY, BY
REGION, 2014-2021 ($ MILLIONS) 93
INVERSE AND STANDARD PCR 93
Market Overview 93
Market Revenue 94
TABLE 39 GLOBAL MARKET FOR INVERSE AND STANDARD PCR TECHNOLOGY BY
REGION, THROUGH 2021 ($ MILLIONS) 94
FIGURE 27 GLOBAL MARKET FOR INVERSE AND STANDARD PCR TECHNOLOGY BY
REGION, 2014-2021 ($ MILLIONS) 94
ASSEMBLY AND NESTED PCR 95
Market Overview 95
Market Revenue 95
TABLE 40 GLOBAL MARKET FOR ASSEMBLY AND NESTED PCR TECHNOLOGY BY
REGION, THROUGH 2021 ($ MILLIONS) 96
FIGURE 28 GLOBAL MARKET FOR ASSEMBLY AND NESTED PCR TECHNOLOGY BY
REGION, 2014-2021 ($ MILLIONS) 96
HOT START AND TOUCHDOWN PCR 96
Market Overview 97
Market Revenue 97
TABLE 41 GLOBAL MARKET FOR HOT START AND TOUCHDOWN PCR TECHNOLOGY
BY REGION, THROUGH 2021 ($ MILLIONS) 97
FIGURE 29 GLOBAL MARKET FOR HOT START AND TOUCHDOWN PCR
TECHNOLOGY BY REGION, 2014-2021 ($ MILLIONS) 98
MULTIPLEX PCR AND OTHER PCR 98
Market Overview 98
Market Revenue 99
TABLE 42 GLOBAL MARKET FOR MULTIPLEX AND OTHER PCR TECHNOLOGIES BY
REGION, THROUGH 2021 ($ MILLIONS) 99
FIGURE 30 GLOBAL MARKET FOR MULTIPLEX AND OTHER PCR TECHNOLOGIES BY
REGION, 2014-2021 ($ MILLIONS) 99
MARKET BY APPLICATION 100
MARKET OVERVIEW 100
MARKET REVENUE 101
TABLE 43 GLOBAL MARKET FOR PCR PRODUCTS BY APPLICATION, THROUGH 2021
($ MILLIONS) 101
FIGURE 31 GLOBAL MARKET FOR PCR PRODUCTS BY APPLICATION, 2014-2021 ($
MILLIONS) 101
MARKET SHARE 102
TABLE 44 GLOBAL MARKET SHARE OF PCR PRODUCTS BY APPLICATION, 2015 (%) 102
FIGURE 32 GLOBAL MARKET SHARE OF PCR PRODUCTS BY APPLICATION, 2015 (%) 102
RESEARCH APPLICATIONS 102
Market Overview 103
Market Revenue by Type 103
TABLE 45 GLOBAL MARKET FOR PCR PRODUCTS FOR RESEARCH APPLICATIONS BY
TYPE, THROUGH 2021 ($ MILLIONS) 104
FIGURE 33 GLOBAL MARKET FOR PCR PRODUCTS FOR RESEARCH APPLICATIONS
BY TYPE, 2014-2021 ($ MILLIONS) 104
Market Revenue by Region 105
TABLE 46 GLOBAL MARKET FOR PCR PRODUCTS FOR RESEARCH APPLICATIONS BY
REGION, THROUGH 2021 ($ MILLIONS) 105
FIGURE 34 GLOBAL MARKET FOR PCR PRODUCTS FOR RESEARCH APPLICATIONS
BY REGION, 2014-2021 ($ MILLIONS) 105
DNA Cloning 106
Market Overview 106
Market Revenue 106
TABLE 47 GLOBAL MARKET FOR DNA CLONING BY REGION, THROUGH 2021 ($
MILLIONS) 107
FIGURE 35 GLOBAL MARKET FOR DNA CLONING BY REGION, 2014-2021 ($
MILLIONS) 107
Gene Expression and Genetic Mapping 107
Market Overview 108
Market Revenue 108
TABLE 48 GLOBAL MARKET FOR GENE EXPRESSION AND GENETIC MAPPING BY
REGION, THROUGH 2021 ($ MILLIONS) 109
FIGURE 36 GLOBAL MARKET FOR GENE EXPRESSION AND GENETIC MAPPING BY
REGION, 2014-2021 ($ MILLIONS) 109
Genotyping 109
Market Overview 110
Market Revenue 110
TABLE 49 GLOBAL MARKET FOR GENOTYPING BY REGION, THROUGH 2021 ($
MILLIONS) 111
FIGURE 37 GLOBAL MARKET FOR GENOTYPING BY REGION, 2014-2021 ($ MILLIONS) 111
DNA Sequencing 111
Market Overview 112
Market Revenue 112
TABLE 50 GLOBAL MARKET FOR DNA SEQUENCING BY REGION, THROUGH 2021 ($
MILLIONS) 113
FIGURE 38 GLOBAL MARKET FOR DNA SEQUENCING BY REGION, 2014-2021 ($
MILLIONS) 113
Forensic Science 113
Market Overview 114
Market Revenue 114
TABLE 51 GLOBAL MARKET FOR FORENSIC SCIENCE BY REGION, THROUGH 2021
($ MILLIONS) 115
FIGURE 39 GLOBAL MARKET FOR FORENSIC SCIENCE BY REGION, 2014-2021 ($
MILLIONS) 115
Bioinformatics 115
Market Overview 116
Market Revenue 116
TABLE 52 GLOBAL MARKET FOR BIOINFORMATICS BY REGION, THROUGH 2021 ($
MILLIONS) 116
FIGURE 40 GLOBAL MARKET FOR BIOINFORMATICS BY REGION, 2014-2021 ($
MILLIONS) 117
Other Research Applications 117
Market Overview 117
Market Revenue 117
TABLE 53 GLOBAL MARKET FOR OTHER RESEARCH BY REGION, THROUGH 2021 ($
MILLIONS) 118
FIGURE 41 GLOBAL MARKET FOR OTHER RESEARCH BY REGION, 2014-2021 ($
MILLIONS) 118
CLINICAL APPLICATIONS 118
Market Overview 119
Market Revenue by Type 119
TABLE 54 GLOBAL MARKET FOR PCR PRODUCTS FOR CLINICAL RESEARCH
APPLICATIONS BY TYPE, THROUGH 2021 ($ MILLIONS) 120
FIGURE 42 GLOBAL MARKET FOR PCR PRODUCTS FOR CLINICAL RESEARCH
APPLICATIONS BY TYPE, 2014-2021 ($ MILLIONS) 120
Market Revenue by Region 121
TABLE 55 GLOBAL MARKET FOR PCR PRODUCTS FOR CLINICAL RESEARCH
APPLICATIONS BY REGION, THROUGH 2021 ($ MILLIONS) 121
FIGURE 43 GLOBAL MARKET FOR PCR PRODUCTS FOR CLINICAL RESEARCH
APPLICATIONS BY REGION, 2014-2021 ($ MILLIONS) 121
Infectious Disease Diagnosis 122
Market Overview 122
Market Revenue 123
TABLE 56 GLOBAL MARKET FOR INFECTIOUS DISEASE DIAGNOSIS BY REGION,
THROUGH 2021 ($ MILLIONS) 123
FIGURE 44 GLOBAL MARKET FOR INFECTIOUS DISEASE DIAGNOSIS BY REGION,
2014-2021 ($ MILLIONS) 123
Genetic Testing 124
Market Overview 124
Market Revenue 125
TABLE 57 GLOBAL MARKET FOR GENETIC TESTING BY REGION, THROUGH 2021 ($
MILLIONS) 125
FIGURE 45 GLOBAL MARKET FOR GENETIC TESTING BY REGION, 2014-2021 ($
MILLIONS) 125
Cancer Therapy Determination 126
Market Overview 126
Market Revenue 127
TABLE 58 GLOBAL MARKET FOR CANCER THERAPY BY REGION, THROUGH 2021 ($
MILLIONS) 127
FIGURE 46 GLOBAL MARKET FOR CANCER THERAPY BY REGION, 2014-2021 ($
MILLIONS) 127
Blood Screening 128
Market Overview 128
Market Revenue 128
TABLE 59 GLOBAL MARKET FOR BLOOD SCREENING BY REGION, THROUGH 2021
($ MILLIONS) 128
FIGURE 47 GLOBAL MARKET FOR BLOOD SCREENING BY REGION, 2014-2021 ($
MILLIONS) 129
Tissue Typing 129
Market Overview 129
Market Revenue 130
TABLE 60 GLOBAL MARKET FOR TISSUE TYPING BY REGION, THROUGH 2021 ($
MILLIONS) 130
FIGURE 48 GLOBAL MARKET FOR TISSUE TYPING BY REGION, 2014-2021 ($
MILLIONS) 130
Prenatal Diagnosis 131
Market Overview 131
Market Revenue 131
TABLE 61 GLOBAL MARKET FOR PRENATAL DIAGNOSIS BY REGION, THROUGH
2021 ($ MILLIONS) 131
FIGURE 49 GLOBAL MARKET FOR PRENATAL DIAGNOSIS BY REGION, 2014-2021 ($
MILLIONS) 132
OTHER PCR APPLICATIONS 132
Market Overview 133
Market Revenue 133
TABLE 62 GLOBAL MARKET FOR OTHER PCR APPLICATION BY REGION, THROUGH
2021 ($ MILLIONS) 133
FIGURE 50 GLOBAL MARKET FOR OTHER PCR APPLICATION BY REGION, 2014-2021
($ MILLIONS) 133
CHAPTER 9 PATENT ANALYSIS 136
PATENTS BY YEAR 136
TABLE 63 NUMBER OF PATENTS BY YEAR, JANUARY 2013-JANUARY 2016 137
FIGURE 51 NUMBER OF PATENTS BY YEAR, JANUARY 2013-JANUARY 2016 137
PATENTS BY TYPE 137
TABLE 64 NUMBER OF PATENTS BY TYPE, JANUARY 2013-JANUARY 2016 137
FIGURE 52 NUMBER OF PATENTS BY TYPE, JANUARY 2013-JANUARY 2016 137
PATENTS BY COMPANY 138
TABLE 65 NUMBER OF PATENTS BY COMPANY, JANUARY 2013-JANUARY 2016 138
PATENTS BY COUNTRY 139
TABLE 66 NUMBER OF PATENTS BY COUNTRY, JANUARY 2013-JANUARY 2016 140
TABLE 67 PATENT SHARES BY COUNTRY, JANUARY 2013-JANUARY 2016 (NO./%) 140
FIGURE 53 PATENT SHARES BY COUNTRY, JANUARY 2013-JANUARY 2016 (%) 140
PATENTS BY ASSIGNEE 141
TABLE 68 NUMBER OF PATENTS BY ASSIGNEE, JANUARY 2013-JANUARY 2016 141
FIGURE 54 NUMBER OF PATENTS BY ASSIGNEE, JANUARY 2013-JANUARY 2016 141
CHAPTER 10 CURRENT SITUATION 144
FACTORS AFFECTING THE PCR MARKET 144
DRIVERS 144
Growth in Proteomics and Genomics 144
Product Launches and Increased Technology Adoption 145
Prevalence of Chronic Diseases and Growth in the Molecular
Diagnostic Industry 145
Broad Range of Applications 146
RESTRAINTS AND CHALLENGES 146
Product Prices 146
Lack of Trained Professionals 146
Lack of Awareness 146
Development of Alternative Technologies 147
OPPORTUNITIES 147
CHAPTER 11 COMPANY PROFILES 149
ABBOTT LABORATORIES 149
AFFYMETRIX INC. 149
AGILENT TECHNOLOGIES INC. 150
ALPHAHELIX MOLECULAR DIAGNOSTICS AB 150
AMPLICON EXPRESS INC. 151
ANASPEC INC. (EUROGENTEC GROUP) 151
BECKMAN COULTER INC. 151
BECTON, DICKINSON and CO. 152
BIOLINE GMBH 152
BIONEER CORP. 153
BIOFIRE DIAGNOSTICS LLC 153
BIO-RAD LABORATORIES INC. 154
COMPLETE GENOMICS INC. 154
ELITECH GROUP MOLECULAR DIAGNOSTICS 155
EPPENDORF AG 156
EXIQON 156
F. HOFFMAN-LA ROCHE LTD. 157
GE ELECTRIC HEALTHCARE LIFE SCIENCES. 157
KAPA BIOSYSTEMS INC. 158
LUCIGEN CORP. 158
LUMINEX CORP. 159
NEW ENGLAND BIOLABS 159
PROMEGA CORP. 159
QIAGEN N.V. 160
QUANTA BIOSCIENCES INC. 160
SIGMA-ALDRICH CORP. 161
TAKARA BIO INC. 161
THERMO FISHER SCIENTIFIC INC. 162
CHAPTER 12 APPENDIX I-ABBREVIATIONS 165
ABBREVIATIONS 165

LIST OF TABLES

SUMMARY TABLE GLOBAL MARKET FOR PCR PRODUCTS BY REGION, THROUGH 2021
($ MILLIONS) 8
TABLE 1 EVOLUTION OF PCR TECHNOLOGY 11
TABLE 2 TRADITIONAL VS. REAL-TIME PCR 16
TABLE 3 ADVANTAGES AND DISADVANTAGES OF DYE-BASED DETECTION 20
TABLE 4 KEY APPLICATIONS OF PCR TECHNOLOGY 23
TABLE 5 NEW APPROVALS OF PCR DEVICES AND KITS BY PREMARKET APPROVAL,
2013- JANUARY 2016 26
TABLE 6 NEW APPROVALS OF PCR DEVICES AND KITS BY 510(K) CLEARANCES,
2013- JANUARY 2016 27
TABLE 7 RECALLS OF DEVICES, FROM 2013 TO JANUARY 2016 31
TABLE 8 NEW PCR PRODUCTS FROM TOP MANUFACTURERS, 2013-JANUARY 2016 34
TABLE 9 MERGERS AND ACQUISITIONS OF TOP PCR COMPANIES, 2013-JANUARY
2016 39
TABLE 10 GLOBAL MARKET FOR PCR PRODUCTS BY TYPE, THROUGH 2021 ($
MILLIONS) 44
TABLE 11 GLOBAL MARKET SHARE OF PCR PRODUCTS BY TYPE, 2015 (%) 44
TABLE 12 GLOBAL MARKET FOR PCR INSTRUMENTS BY TYPE, THROUGH 2021 ($
MILLIONS) 47
TABLE 13 GLOBAL MARKET FOR PCR INSTRUMENTS BY REGION,THROUGH 2021 ($
MILLIONS) 48
TABLE 14 GLOBAL MARKET FOR THERMAL CYCLERS BY REGION, THROUGH 2021 ($
MILLIONS) 49
TABLE 15 GLOBAL MARKET FOR REAL-TIME PCR INSTRUMENTS BY REGION,
THROUGH 2021 ($ MILLIONS) 51
TABLE 16 GLOBAL MARKET FOR PCR REAGENTS AND CONSUMABLES BY TYPE,
THROUGH 2021 ($ MILLIONS) 54
TABLE 17 GLOBAL MARKET FOR PCR REAGENTS AND CONSUMABLES BY REGION,
THROUGH 2021 ($ MILLIONS) 55
TABLE 18 GLOBAL MARKET FOR PCR INDIVIDUAL REAGENTS BY TYPE, THROUGH
2021 ($ MILLIONS) 58
TABLE 19 GLOBAL MARKET FOR PCR INDIVIDUAL REAGENTS BY REGION, THROUGH
2021 ($ MILLIONS) 59
TABLE 20 GLOBAL MARKET FOR PCR MASTER MIXES/ REAGENT KITS BY REGION,
THROUGH 2021 ($ MILLIONS) 61
TABLE 21 GLOBAL MARKET FOR OTHER REAGENTS BY REGION, THROUGH 2021 ($
MILLIONS) 63
TABLE 22 GLOBAL MARKET FOR CONSUMABLES BY REGION, THROUGH 2021 ($
MILLIONS) 64
TABLE 23 GLOBAL MARKET FOR PCR SOFTWARE BY TYPE, THROUGH 2021 ($
MILLIONS) 66
TABLE 24 GLOBAL MARKET FOR PCR SOFTWARE BY REGION, THROUGH 2021 ($
MILLIONS) 67
TABLE 25 GLOBAL MARKET FOR PRIMER DESIGN AND SEQUENCING SOFTWARE BY
REGION, THROUGH 2021 ($ MILLIONS) 69
TABLE 26 GLOBAL MARKET FOR PCR ANALYZER SOFTWARE BY REGION, THROUGH
2021 ($ MILLIONS) 71
TABLE 27 GLOBAL MARKET FOR OTHER SOFTWARE BY REGION, THROUGH 2021 ($
MILLIONS) 72
TABLE 28 GLOBAL MARKET FOR PCR SERVICES BY REGION, THROUGH 2021 ($
MILLIONS) 74
TABLE 29 LEADING MANUFACTURERS/SUPPLIERS OF PCR INSTRUMENTS, 2015 76
TABLE 30 GLOBAL MARKET SHARE OF MANUFACTURERS/SUPPLIERS OF PCR
INSTRUMENTS, 2015 (%) 77
TABLE 31 LEADING MANUFACTURERS/SUPPLIERS OF PCR REAGENTS AND
CONSUMABLES, 2015 78
TABLE 32 GLOBAL MARKET SHARE OF MANUFACTURERS/SUPPLIERS OF PCR
REAGENTS AND CONSUMABLES, 2015 (%) 81
TABLE 33 LEADING MANUFACTURERS/SUPPLIERS OF PCR SOFTWARE, 2015 83
TABLE 34 GLOBAL MARKET SHARE OF MANUFACTURERS/SUPPLIERS OF PCR
SOFTWARE, 2015 (%) 84
TABLE 35 GLOBAL MARKET FOR PCR TECHNOLOGY BY TYPE, THROUGH 2021 ($
MILLIONS) 88
TABLE 36 GLOBAL MARKET SHARE OF PCR TECHNOLOGY BY TYPE, 2015 (%) 88
TABLE 37 GLOBAL MARKET FOR REAL-TIME PCR TECHNOLOGY BY REGION,
THROUGH 2021 ($ MILLIONS) 91
TABLE 38 GLOBAL MARKET FOR REVERSE TRANSCRIPTASE PCR TECHNOLOGY BY
REGION, THROUGH 2021 ($ MILLIONS) 92
TABLE 39 GLOBAL MARKET FOR INVERSE AND STANDARD PCR TECHNOLOGY BY
REGION, THROUGH 2021 ($ MILLIONS) 94
TABLE 40 GLOBAL MARKET FOR ASSEMBLY AND NESTED PCR TECHNOLOGY BY
REGION, THROUGH 2021 ($ MILLIONS) 96
TABLE 41 GLOBAL MARKET FOR HOT START AND TOUCHDOWN PCR TECHNOLOGY
BY REGION, THROUGH 2021 ($ MILLIONS) 97
TABLE 42 GLOBAL MARKET FOR MULTIPLEX AND OTHER PCR TECHNOLOGIES BY
REGION, THROUGH 2021 ($ MILLIONS) 99
TABLE 43 GLOBAL MARKET FOR PCR PRODUCTS BY APPLICATION, THROUGH 2021
($ MILLIONS) 101
TABLE 44 GLOBAL MARKET SHARE OF PCR PRODUCTS BY APPLICATION, 2015 (%) 102
TABLE 45 GLOBAL MARKET FOR PCR PRODUCTS FOR RESEARCH APPLICATIONS BY
TYPE, THROUGH 2021 ($ MILLIONS) 104
TABLE 46 GLOBAL MARKET FOR PCR PRODUCTS FOR RESEARCH APPLICATIONS BY
REGION, THROUGH 2021 ($ MILLIONS) 105
TABLE 47 GLOBAL MARKET FOR DNA CLONING BY REGION, THROUGH 2021 ($
MILLIONS) 107
TABLE 48 GLOBAL MARKET FOR GENE EXPRESSION AND GENETIC MAPPING BY
REGION, THROUGH 2021 ($ MILLIONS) 109
TABLE 49 GLOBAL MARKET FOR GENOTYPING BY REGION, THROUGH 2021 ($
MILLIONS) 111
TABLE 50 GLOBAL MARKET FOR DNA SEQUENCING BY REGION, THROUGH 2021 ($
MILLIONS) 113
TABLE 51 GLOBAL MARKET FOR FORENSIC SCIENCE BY REGION, THROUGH 2021 ($
MILLIONS) 115
TABLE 52 GLOBAL MARKET FOR BIOINFORMATICS BY REGION, THROUGH 2021 ($
MILLIONS) 116
TABLE 53 GLOBAL MARKET FOR OTHER RESEARCH BY REGION, THROUGH 2021 ($
MILLIONS) 118
TABLE 54 GLOBAL MARKET FOR PCR PRODUCTS FOR CLINICAL RESEARCH
APPLICATIONS BY TYPE, THROUGH 2021 ($ MILLIONS) 120
TABLE 55 GLOBAL MARKET FOR PCR PRODUCTS FOR CLINICAL RESEARCH
APPLICATIONS BY REGION, THROUGH 2021 ($ MILLIONS) 121
TABLE 56 GLOBAL MARKET FOR INFECTIOUS DISEASE DIAGNOSIS BY REGION,
THROUGH 2021 ($ MILLIONS) 123
TABLE 57 GLOBAL MARKET FOR GENETIC TESTING BY REGION, THROUGH 2021 ($
MILLIONS) 125
TABLE 58 GLOBAL MARKET FOR CANCER THERAPY BY REGION, THROUGH 2021 ($
MILLIONS) 127
TABLE 59 GLOBAL MARKET FOR BLOOD SCREENING BY REGION, THROUGH 2021 ($
MILLIONS) 128
TABLE 60 GLOBAL MARKET FOR TISSUE TYPING BY REGION, THROUGH 2021 ($
MILLIONS) 130
TABLE 61 GLOBAL MARKET FOR PRENATAL DIAGNOSIS BY REGION, THROUGH 2021
($ MILLIONS) 131
TABLE 62 GLOBAL MARKET FOR OTHER PCR APPLICATION BY REGION, THROUGH
2021 ($ MILLIONS) 133
TABLE 63 NUMBER OF PATENTS BY YEAR, JANUARY 2013-JANUARY 2016 137
TABLE 64 NUMBER OF PATENTS BY TYPE, JANUARY 2013-JANUARY 2016 137
TABLE 65 NUMBER OF PATENTS BY COMPANY, JANUARY 2013-JANUARY 2016 138
TABLE 66 NUMBER OF PATENTS BY COUNTRY, JANUARY 2013-JANUARY 2016 140
TABLE 67 PATENT SHARES BY COUNTRY, JANUARY 2013-JANUARY 2016 (NO./%) 140
TABLE 68 NUMBER OF PATENTS BY ASSIGNEE, JANUARY 2013-JANUARY 2016 141

LIST OF FIGURES

SUMMARY FIGURE 8
FIGURE 1 GLOBAL MARKET FOR PCR PRODUCTS BY TYPE, 2014-2021 ($ MILLIONS) 44
FIGURE 2 GLOBAL MARKET SHARE OF PCR PRODUCTS BY TYPE, 2015 (%) 45
FIGURE 3 GLOBAL MARKET FOR PCR INSTRUMENTS BY TYPE, 2014-2021 ($
MILLIONS) 47
FIGURE 4 GLOBAL MARKET FOR PCR INSTRUMENTS BY REGION, 2014-2021 ($
MILLIONS) 48
FIGURE 5 GLOBAL MARKET FOR THERMAL CYCLERS BY REGION, 2014-2021 ($
MILLIONS) 49
FIGURE 6 GLOBAL MARKET FOR REAL-TIME PCR INSTRUMENTS BY REGION,
2014-2021 ($ MILLIONS) 51
FIGURE 7 GLOBAL MARKET FOR PCR REAGENTS AND CONSUMABLES BY TYPE,
2014-2021 ($ MILLIONS) 54
FIGURE 8 GLOBAL MARKET FOR PCR REAGENTS AND CONSUMABLES BY REGION,
2014-2021 ($ MILLIONS) 55
FIGURE 9 GLOBAL MARKET FOR PCR INDIVIDUAL REAGENTS BY TYPE, 2014-2021 ($
MILLIONS) 58
FIGURE 10 GLOBAL MARKET FOR PCR INDIVIDUAL REAGENTS BY REGION,
2014-2021 ($ MILLIONS) 59
FIGURE 11 GLOBAL MARKET FOR PCR MASTER MIXES/REAGENT KITS BY REGION,
2014-2021 ($ MILLIONS) 61
FIGURE 12 GLOBAL MARKET FOR OTHER REAGENTS BY REGION, 2014-2021 ($
MILLIONS) 63
FIGURE 13 GLOBAL MARKET FOR CONSUMABLES BY REGION, 2014-2021 ($
MILLIONS) 64
FIGURE 14 GLOBAL MARKET FOR PCR SOFTWARE BY TYPE, 2014-2021 ($ MILLIONS) 66
FIGURE 15 GLOBAL MARKET FOR PCR SOFTWARE BY REGION, 2014-2021 ($
MILLIONS) 68
FIGURE 16 GLOBAL MARKET FOR PRIMER DESIGN AND SEQUENCING SOFTWARE BY
REGION, 2014-2021 ($ MILLIONS) 69
FIGURE 17 GLOBAL MARKET FOR PCR ANALYZER SOFTWARE BY REGION, 2014-2021
($ MILLIONS) 71
FIGURE 18 GLOBAL MARKET FOR OTHER SOFTWARE BY REGION, 2014-2021 ($
MILLIONS) 73
FIGURE 19 GLOBAL MARKET FOR PCR SERVICES BY REGION, 2014-2021 ($ MILLIONS) 74
FIGURE 20 GLOBAL MARKET SHARE OF MANUFACTURERS/SUPPLIERS OF PCR
INSTRUMENTS, 2015 (%) 77
FIGURE 21 GLOBAL MARKET SHARE OF MANUFACTURERS/SUPPLIERS OF PCR
REAGENTS AND CONSUMABLES, 2015 (%) 82
FIGURE 22 GLOBAL MARKET SHARE OF MANUFACTURERS/SUPPLIERS OF PCR
SOFTWARE, 2015 (%) 84
FIGURE 23 GLOBAL MARKET FOR PCR TECHNOLOGY BY TYPE, 2014-2021 ($
MILLIONS) 88
FIGURE 24 GLOBAL MARKET SHARE OF PCR TECHNOLOGY BY TYPE, 2015 (%) 89
FIGURE 25 GLOBAL MARKET FOR REAL-TIME PCR TECHNOLOGY BY REGION,
2014-2021 ($ MILLIONS) 91
FIGURE 26 GLOBAL MARKET FOR REVERSE TRANSCRIPTASE PCR TECHNOLOGY, BY
REGION, 2014-2021 ($ MILLIONS) 93
FIGURE 27 GLOBAL MARKET FOR INVERSE AND STANDARD PCR TECHNOLOGY BY
REGION, 2014-2021 ($ MILLIONS) 94
FIGURE 28 GLOBAL MARKET FOR ASSEMBLY AND NESTED PCR TECHNOLOGY BY
REGION, 2014-2021 ($ MILLIONS) 96
FIGURE 29 GLOBAL MARKET FOR HOT START AND TOUCHDOWN PCR TECHNOLOGY
BY REGION, 2014-2021 ($ MILLIONS) 98
FIGURE 30 GLOBAL MARKET FOR MULTIPLEX AND OTHER PCR TECHNOLOGIES BY
REGION, 2014-2021 ($ MILLIONS) 99
FIGURE 31 GLOBAL MARKET FOR PCR PRODUCTS BY APPLICATION, 2014-2021 ($
MILLIONS) 101
FIGURE 32 GLOBAL MARKET SHARE OF PCR PRODUCTS BY APPLICATION, 2015 (%) 102
FIGURE 33 GLOBAL MARKET FOR PCR PRODUCTS FOR RESEARCH APPLICATIONS BY
TYPE, 2014-2021 ($ MILLIONS) 104
FIGURE 34 GLOBAL MARKET FOR PCR PRODUCTS FOR RESEARCH APPLICATIONS BY
REGION, 2014-2021 ($ MILLIONS) 105
FIGURE 35 GLOBAL MARKET FOR DNA CLONING BY REGION, 2014-2021 ($ MILLIONS) 107
FIGURE 36 GLOBAL MARKET FOR GENE EXPRESSION AND GENETIC MAPPING BY
REGION, 2014-2021 ($ MILLIONS) 109
FIGURE 37 GLOBAL MARKET FOR GENOTYPING BY REGION, 2014-2021 ($ MILLIONS) 111
FIGURE 38 GLOBAL MARKET FOR DNA SEQUENCING BY REGION, 2014-2021 ($
MILLIONS) 113
FIGURE 39 GLOBAL MARKET FOR FORENSIC SCIENCE BY REGION, 2014-2021 ($
MILLIONS) 115
FIGURE 40 GLOBAL MARKET FOR BIOINFORMATICS BY REGION, 2014-2021 ($
MILLIONS) 117
FIGURE 41 GLOBAL MARKET FOR OTHER RESEARCH BY REGION, 2014-2021 ($
MILLIONS) 118
FIGURE 42 GLOBAL MARKET FOR PCR PRODUCTS FOR CLINICAL RESEARCH
APPLICATIONS BY TYPE, 2014-2021 ($ MILLIONS) 120
FIGURE 43 GLOBAL MARKET FOR PCR PRODUCTS FOR CLINICAL RESEARCH
APPLICATIONS BY REGION, 2014-2021 ($ MILLIONS) 121
FIGURE 44 GLOBAL MARKET FOR INFECTIOUS DISEASE DIAGNOSIS BY REGION,
2014-2021 ($ MILLIONS) 123
FIGURE 45 GLOBAL MARKET FOR GENETIC TESTING BY REGION, 2014-2021 ($
MILLIONS) 125
FIGURE 46 GLOBAL MARKET FOR CANCER THERAPY BY REGION, 2014-2021 ($
MILLIONS) 127
FIGURE 47 GLOBAL MARKET FOR BLOOD SCREENING BY REGION, 2014-2021 ($
MILLIONS) 129
FIGURE 48 GLOBAL MARKET FOR TISSUE TYPING BY REGION, 2014-2021 ($
MILLIONS) 130
FIGURE 49 GLOBAL MARKET FOR PRENATAL DIAGNOSIS BY REGION, 2014-2021 ($
MILLIONS) 132
FIGURE 50 GLOBAL MARKET FOR OTHER PCR APPLICATION BY REGION, 2014-2021
($ MILLIONS) 133
FIGURE 51 NUMBER OF PATENTS BY YEAR, JANUARY 2013-JANUARY 2016 137
FIGURE 52 NUMBER OF PATENTS BY TYPE, JANUARY 2013-JANUARY 2016 137
FIGURE 53 PATENT SHARES BY COUNTRY, JANUARY 2013-JANUARY 2016 (%) 140
FIGURE 54 NUMBER OF PATENTS BY ASSIGNEE, JANUARY 2013-JANUARY 2016 141

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