U.S. Market for Dental Bone Graft Substitutes, Dental Membranes and Tissue Engineering Products 2012

The total U.S. market for dental bone graft substitutes and other biomaterials is expected to grow at a CAGR of 12% over the 2012–2018 forecast period. The U.S. market for dental bone graft substitutes and other biomaterials includes the markets for:

- Dental Bone Graft Substitutes including:

o Autografts
o Allografts
o De-mineralized Bone Matrix (DBM) Allografts
o Xenografts
o Synthetics

- Tissue Engineering Products

- Dental Membranes

The dental bone graft substitute market is segmented by:

- Material
- Procedure

The market is expected to grow rapidly as the number of bone graft procedures associated with dental implants rises. The dental bone graft substitute market will therefore be largely driven by the high demand for dental implants. In particular, many dental implant manufacturers are expanding their regenerative product lines to bolster their implant sales.

Within the dental bone graft substitute market, companies such as ACE Dental, BioHorizons, Osteohealth and Zimmer Dental lead the market, among many others. This report provides a comprehensive and detailed analysis of market revenues by device type, market forecasts through 2018, unit sales, average selling prices, market drivers and limiters and a detailed competitive analysis, including manufacturer market shares and product portfolios.

Biomaterial Industry in the United States

TABLE OF CONTENTS

TABLE OF CONTENTS....I
LIST OF FIGURES.V
LIST OF CHARTS......... VII
EXECUTIVE SUMMARY 1
1.1 U.S. DENTAL BONE GRAFT SUBSTITUTES AND OTHER BIOMATERIALS MARKET ..... 1
1.2 DENTAL BONE GRAFT SUBSTITUTE MARKET ....... 2
1.3 DENTAL BONE GRAFTING PROCEDURE NUMBERS 3
1.4 DENTAL BONE GRAFT SUBSTITUTES BY MATERIAL TYPE.......... 4
1.5 TISSUE ENGINEERING PRODUCT MARKET.. 5
1.6 DENTAL MEMBRANE MARKET........ 6
1.7 COMPETITIVE ANALYSIS ...... 7
RESEARCH METHODOLOGY. 8
2.1 RESEARCH SCOPE ...... 8
2.2 IDATA’S 9-STEP METHODOLOGY .... 8
Step 1: Project Initiation & Team Selection .......... 9
Step 2: Prepare Data Systems and Perform Secondary Research........ 11
Step 3: Preparation for Interviews & Questionnaire Design .... 12
Step 4: Performing Primary Research...... 13
Step 5: Research Analysis: Establishing Baseline Estimates .... 15
Step 6: Market Forecast and Analysis ...... 16
Step 7: Identify Strategic Opportunities ... 18
Step 8: Final Review and Market Release 19
Step 9: Customer Feedback and Market Monitoring...... 20
U.S. MARKET FOR DENTAL BONE GRAFT SUBSTITUTES AND OTHER
BIOMATERIALS.. 21
3.1 INTRODUCTION ........ 21
3.1.1 Applications of Dental Bone Graft Substitutes ......... 21
3.1.1.1 Dental Implant Procedures.22
3.1.1.2 Periodontal Procedures......22
3.1.2 Types of Dental Bone Graft Substitutes ......... 23
3.1.2.1 Autografts .....23
3.1.2.2 Allografts ......23
3.1.2.3 De-Mineralized Bone Matrix (DBM) Allografts..24
3.1.2.4 Xenografts.....25
3.1.2.5 Synthetics ......25
3.1.3 Tissue Engineering Products ... 26
3.1.4 Dental Membranes........ 26
3.1.5 Market Penetration and End Users .... 26
3.2 MARKET BY SEGMENT........ 27
3.3 MARKET DRIVERS AND LIMITERS . 31
3.3.1 Market Drivers... 31
3.3.2 Market Limiters.. 32
3.4 COMPETITIVE ANALYSIS .... 35
3.5 MERGERS, ACQUISITIONS AND PARTNERSHIPS ... 40
PROCEDURE NUMBERS......... 42
4.1 INTRODUCTION ........ 42
4.2 DENTAL BONE GRAFTING PROCEDURES .. 43
DENTAL BONE GRAFT SUBSTITUTE MARKET .......... 49
5.1 DENTAL BONE GRAFTING PROCEDURES .. 49
5.1.1 Autografts 49
5.1.2 Allografts 50
5.1.3 De-Mineralized Bone Matrix (DBM).. 51
5.1.4 Xenografts.......... 52
5.1.5 Synthetics 52
5.2 MARKET OVERVIEW 54
5.2.1 Dental Bone Graft Substitute Market by Material.... 54
5.2.2 Dental Bone Graft Substitute Market by Segment .... 56
5.3 MARKET ANALYSIS AND FORECAST ........ 59
5.3.1 Average Selling Price ... 62
5.3.2 Autograft Market 65
5.3.3 Mineralized Allograft Market .. 67
5.3.4 De-Mineralized Bone Matrix (DBM) Market 70
5.3.5 Xenograft Market.......... 73
5.3.6 Synthetic Market 76
5.4 MARKET DRIVERS AND LIMITERS . 78
5.4.1 Total Dental Bone Graft Substitute Market ... 78
5.4.1.1 Market Drivers.........78
5.4.1.2 Market Limiters .......80
5.4.2 Autograft Market 82
5.4.2.1 Market Drivers.........82
5.4.2.2 Market Limiters .......82
5.4.3 Mineralized Allograft Market .. 84
5.4.3.1 Market Drivers.........84
5.4.3.2 Market Limiters .......84
5.4.4 De-Mineralized Bone Matrix Market.. 86
5.4.4.1 Market Drivers.........86
5.4.4.2 Market Limiters .......86
5.4.5 Xenograft Market.......... 87
5.4.5.1 Market Drivers.........87
5.4.5.2 Market Limiters .......87
5.4.6 Synthetic Market 89
5.4.6.1 Market Drivers.........89
5.4.6.2 Market Limiters .......89
5.5 COMPETITIVE ANALYSIS .... 91
5.5.1 Total Dental Bone Graft Substitute Market ... 91
5.5.2 Mineralized Allograft Market .. 97
5.5.3 De-Mineralized Bone Matrix Market 101
5.5.4 Xenograft Market........ 105
5.5.5 Synthetic Market ......... 108
TISSUE ENGINEERING PRODUCT MARKET... 112
6.1 INTRODUCTION ...... 112
6.2 MARKET ANALYSIS AND FORECAST ...... 114
6.2.1 Total Tissue Engineering Product Market... 114
6.2.2 Emdogain™ Market... 117
6.2.3 GEM 21S® Market ...... 119
6.2.4 INFUSE® Market ........ 121
6.2.5 Osteocel® Market ........ 124
6.3 EMERGING TECHNOLOGIES ......... 126
6.3.1 Platelet Rich Plasma (PRP)... 126
6.3.2 Stem Cell Based Therapies .... 127
6.4 MARKET DRIVERS AND LIMITERS .......... 128
6.4.1 Market Drivers. 128
6.4.2 Market Limiters 129
6.5 COMPETITIVE ANALYSIS .. 131
6.5.1 Emerging Competitors and Technological Developments. 134
DENTAL MEMBRANE MARKET ... 135
7.1 INTRODUCTION ...... 135
7.2 MARKET ANALYSIS AND FORECAST ...... 136
7.2.1 Market by Product Type ........ 139
7.2.1.1 Resorbable Membranes ....139
7.2.1.2 Non-Resorbable Membranes .......139
7.3 MARKET DRIVERS AND LIMITERS .......... 142
7.3.1 Market Drivers. 142
7.3.2 Market Limiters 142
7.4 COMPETITIVE ANALYSIS .. 144
ABBREVIATIONS......... 148

LIST OF FIGURES

EXECUTIVE SUMMARY....... 1
RESEARCH METHODOLOGY.......... 8
U.S. MARKET FOR DENTAL BONE GRAFT SUBSTITUTES AND OTHER
BIOMATERIALS .. 21
Figure 3-1: Total Dental Bone Graft Substitutes and Other Biomaterials Market
by Segment, U.S., 2008 – 2018 (US$M) .. 27
Figure 3-2: Drivers and Limiters, Dental Bone Graft Substitutes and Other
Biomaterials Market, U.S., 2011 .. 34
Figure 3-3: Leading Competitors, Dental Bone Graft Substitutes and Other
Biomaterials Market, U.S., 2011 .. 38
PROCEDURE NUMBERS..... 42
Figure 4-1: Procedures and Penetration Rates, Dental Bone Graft Substitute
Market, U.S., 2008 – 2018 44
Figure 4-2: Dental Implant Associated and Periodontal Bone Grafting Procedure
Volume Usage, U.S., 2008 – 2018 (Part 1 of 2) .. 46
Figure 4-3: Dental Implant Associated and Periodontal Bone Grafting Procedure
Volume Usage, U.S., 2008 – 2018 (Part 2 of 2) . 47
DENTAL BONE GRAFT SUBSTITUTE MARKET 49
Figure 5-1: Units Sold by Material, Dental Bone Graft Substitute Market, U.S.,
2008 – 2018 54
Figure 5-2: Dental Bone Graft Substitute Market by Segment, U.S., 2008 – 2018
(US$M) ...... 57
Figure 5-3: Dental Bone Graft Substitute Market, U.S., 2008 – 2018 ....... 60
Figure 5-4: Average Selling Price, Dental Bone Graft Substitute Market, U.S.,
2008 – 2018 62
Figure 5-5: Dental Autograft Potential Market, U.S., 2008 – 2018. 65
Figure 5-6: Mineralized Allograft Market, U.S., 2008 – 2018........ 68
Figure 5-7: De-Mineralized Bone Matrix Market, U.S., 2008 – 2018 ....... 71
Figure 5-8: Xenograft Market, U.S., 2008 – 2018... 74
Figure 5-9: Synthetic Market, U.S., 2008 – 2018.... 76
Figure 5-10: Drivers and Limiters, Dental Bone Graft Substitute Market, U.S.,
2011 81
Figure 5-11: Drivers and Limiters, Autograft Market, U.S., 2011 .. 83
Figure 5-12: Drivers and Limiters, Mineralized Allograft Market, U.S., 2011 ...... 85
Figure 5-13: Drivers and Limiters, De-Mineralized Bone Matrix Market, U.S.,
2011 86
Figure 5-14: Drivers and Limiters, Xenograft Market, U.S., 2011.. 88
Figure 5-15: Drivers and Limiters, Synthetic Market, U.S., 2011... 90
Figure 5-16: Leading Competitors, Dental Bone Graft Substitute Market, U.S.,
2011 95
Figure 5-17: Leading Competitors, Mineralized Allograft Market, U.S., 2011...... 99
Figure 5-18: Leading Competitors, De-Mineralized Bone Matrix Market, U.S.,
2011 ......... 103
Figure 5-19: Leading Competitors, Xenograft Market, U.S., 2011 .......... 106
Figure 5-20: Leading Competitors, Synthetic Market, U.S., 2011 110
TISSUE ENGINEERING PRODUCT MARKET ... 112
Figure 6-1: Tissue Engineering Product Market by Segment, U.S., 2008 – 2018
(US$M) .... 115
Figure 6-2: Emdogain™ Market, U.S., 2008 – 2018 ......... 117
Figure 6-3: GEM 21S® Market, U.S., 2008 – 2018. 119
Figure 6-4: INFUSE® Market, U.S., 2008 – 2018 .. 122
Figure 6-5: Osteocel® Market, U.S., 2008 – 2018 .. 124
Figure 6-6: Drivers and Limiters, Tissue Engineering Product Market, U.S.,
2011 ......... 130
Figure 6-7: Leading Competitors, Tissue Engineering Product Market, U.S.,
2011 ......... 132
DENTAL MEMBRANE MARKET . 135
Figure 7-1: Dental Membrane Market, U.S., 2008 – 2018 . 137
Figure 7-2: Units Sold by Segment, Dental Membrane Market, U.S.,
2008 – 2018......... 140
Figure 7-3: Drivers and Limiters, Dental Membrane Market, U.S., 2011. 143
Figure 7-4: Leading Competitors, Dental Membrane Market, U.S., 2011 146
ABBREVIATIONS .. 148

LIST OF CHARTS

EXECUTIVE SUMMARY....... 1
Chart 1-1: Total Dental Bone Graft Substitutes and Other Biomaterials Market,
U.S., 2008 – 2018 .... 1
Chart 1-2: Dental Bone Graft Substitute Market, U.S., 2008 – 2018 2
Chart 1-3: Dental Bone Graft Procedure Breakdown, U.S., 2008 – 2018 ..... 3
Chart 1-4: Unit Share by Material Type, Dental Bone Graft Substitute Market,
U.S., 2008 – 2018 .... 4
Chart 1-5: Market Share, Tissue Engineering Product Market, U.S.,
2008 – 2018.. 5
Chart 1-6: Units by Type, Dental Membrane Market, U.S., 2008 – 2018 .... 6
Chart 1-7: Leading Competitors, Dental Bone Graft Substitutes and Other
Biomaterials Market, U.S., 2011 .... 7
RESEARCH METHODOLOGY.......... 8
U.S. MARKET FOR DENTAL BONE GRAFT SUBSTITUTES AND OTHER
BIOMATERIALS .. 21
Chart 3-1: Total Dental Bone Graft Substitutes and Other Biomaterials Market by
Segment, U.S., 2008 – 2018 (US$M)....... 28
Chart 3-2: Total Dental Bone Graft Substitutes and Other Biomaterials Market by
Segment, U.S., 2011 ........ 29
Chart 3-3: Total Dental Bone Graft Substitutes and Other Biomaterials Market by
Segment, U.S., 2018 ........ 30
Chart 3-4: Leading Competitors, Dental Bone Graft Substitutes and Other
Biomaterials Market, U.S., 2011 . 39
PROCEDURE NUMBERS..... 42
Chart 4-1: Bone Graft Volume Usage by Application, Dental Bone Graft
Substitute Market, U.S., 2008 – 2018 ..... 45
Chart 4-2: Percentage of Bone Graft Volume Used by Procedure Type, Dental
Bone Graft Substitute Market, U.S., 2008 – 2018 .......... 48
DENTAL BONE GRAFT SUBSTITUTE MARKET 49
Chart 5-1: Units Sold by Material, Dental Bone Graft Substitute Market, U.S.,
2008 – 2018 55
Chart 5-2: Dental Bone Graft Substitute Market by Segment, U.S., 2008 – 2018 . 58
Chart 5-3: Dental Bone Graft Substitutes Market, U.S., 2008 – 2018 ...... 61
Chart 5-4: Average Selling Price, Dental Bone Graft Substitute Market, U.S.,
2008 – 2018 63
Chart 5-5: Dental Bone Graft Substitute Market by Price Range, U.S., 2011 ....... 64
Chart 5-6: Dental Autograft Potential Market, U.S., 2008 – 2018 . 66
Chart 5-7: Mineralized Allograft Market, U.S., 2008 – 2018 ........ 69
Chart 5-8: De-Mineralized Bone Matrix Market, U.S., 2008 – 2018 ........ 72
Chart 5-9: Xenograft Market, U.S., 2008 – 2018 ... 75
Chart 5-10: Synthetic Market, U.S., 2008 – 2018 .. 77
Chart 5-11: Leading Competitors, Dental Bone Graft Substitute Market, U.S.,
2011 .......... 96
Chart 5-12: Leading Competitors, Mineralized Allograft Market, U.S., 2011 .... 100
Chart 5-13: Leading Competitors, De-Mineralized Bone Matrix Market, U.S.,
2011 ........ 104
Chart 5-14: Leading Competitors, Xenograft Market, U.S., 2011 107
Chart 5-15: Leading Competitors, Synthetic Market, U.S., 2011 . 111
TISSUE ENGINEERING PRODUCT MARKET ... 112
Chart 6-1: Tissue Engineering Product Market by Segment, U.S., 2008 – 2018 . 116
Chart 6-2: Emdogain™ Market, U.S., 2008 – 2018 .......... 118
Chart 6-3: GEM 21S® Market, U.S., 2008 – 2018 . 120
Chart 6-4: INFUSE® Market, U.S., 2008 – 2018 ... 123
Chart 6-5: Osteocel® Market, U.S., 2008 – 2018 .. 125
Chart 6-6: Leading Competitors, Tissue Engineering Product Market, U.S.,
2011 ......... 133
DENTAL MEMBRANE MARKET . 135
Chart 7-1: Dental Membrane Market, U.S., 2008 – 2018 . 138
Chart 7-2: Units Sold by Segment, Dental Membrane Market, U.S.,
2008 – 2018 ........ 141
Chart 7-3: Leading Competitors, Dental Membrane Market, U.S., 2011 .. 147
ABBREVIATIONS .. 148