Report description
The Personalized Medicine Partnering Terms and Agreements report provides comprehensive understanding and unprecedented access to the personalized medicine partnering deals and agreements entered into by the worlds leading healthcare companies.
The report provides a detailed understanding and analysis of how and why companies enter personalized medicine partnering deals. The majority of deals are discovery or development stage whereby the licensee obtains a right or an option right to license the licensors personalized medicine technology. These deals tend to be multicomponent, starting with collaborative R&D, and commercialization of outcomes.
Understanding the flexibility of a prospective partner’s negotiated deals terms provides critical insight into the negotiation process in terms of what you can expect to achieve during the negotiation of terms. Whilst many smaller companies will be seeking details of the payments clauses, the devil is in the detail in terms of how payments are triggered – contract documents provide this insight where press releases do not.
This report contains over 1,500 links to online copies of actual personalized medicine deals and contract documents as submitted to the Securities Exchange Commission by companies and their partners. Contract documents provide the answers to numerous questions about a prospective partner’s flexibility on a wide range of important issues, many of which will have a significant impact on each party’s ability to derive value from the deal.
The initial chapters of this report provide an orientation of personalized medicine dealmaking and business activities. Chapter 1 provides an introduction to the report, whilst chapter 2 provides an overview of the trends in personalized medicine dealmaking since 2007, including details of average headline, upfront, milestone and royalty terms.
Chapter 3 provides a review of the leading biomarker deals since 2007. Deals are listed by headline value, signed by bigpharma, most active bigpharma, and most active of all biopharma companies. Where the deal has an agreement contract published at the SEC a link provides online access to the contract.
Chapter 4 provides a review of the leading companion diagnostic deals since 2007. Deals are listed by headline value, signed by bigpharma, most active bigpharma, and most active of all biopharma companies. Where the deal has an agreement contract published at the SEC a link provides online access to the contract.
Chapter 5 provides a review of the leading pharmacogenomic deals since 2007. Deals are listed by headline value, signed by bigpharma, most active bigpharma, and most active of all biopharma companies. Where the deal has an agreement contract published at the SEC a link provides online access to the contract.
Chapter 6 provides a comprehensive listing of the top 50 bigpharma companies with a brief summary followed by a comprehensive listing of personalized medicine deals including biomarker, companion diagnostic, pharmacogenomics, as well as contract documents available in the public domain. Where available, each deal title links via Weblink to an online version of the actual contract document, providing easy access to each contract document on demand.
Chapter 7 provides a comprehensive and detailed review of biomarker partnering deals signed and announced since 2007, where a contract document is available in the public domain. The chapter is organized by company A-Z, stage of development at signing, deal type (collaborative R&D, co-promotion, licensing etc), and specific therapy focus. Each deal title links via Weblink to an online version of the deal record and where available, the contract document, providing easy access to each contract document on demand.
Chapter 8 provides a comprehensive and detailed review of companion diagnostics partnering deals signed and announced since 2007, where a contract document is available in the public domain. The chapter is organized by company A-Z, stage of development at signing, deal type (collaborative R&D, co-promotion, licensing etc), and specific therapy focus. Each deal title links via Weblink to an online version of the deal record and where available, the contract document, providing easy access to each contract document on demand.
Chapter 9 provides a comprehensive and detailed review of pharmacogenomic partnering deals signed and announced since 2007, where a contract document is available in the public domain. The chapter is organized by company A-Z, stage of development at signing, deal type (collaborative R&D, co-promotion, licensing etc), and specific therapy focus. Each deal title links via Weblink to an online version of the deal record and where available, the contract document, providing easy access to each contract document on demand.
The report also includes numerous tables and figures that illustrate the trends and activities in personalized medicine partnering and dealmaking since 2007.
In conclusion, this report provides everything a prospective dealmaker needs to know about partnering in the research, development and commercialization of personalized medicine technologies and products.
Key benefits
Personalized Medicine Partnering Terms and Agreements provides the reader with the following Key benefits:
• In-depth understanding of personalized medicine deal trends since 2007
• Access to headline, upfront, milestone and royalty data
• Analysis of the structure of personalized medicine agreements with numerous real life case studies
• Comprehensive access to over 1,500 actual personalized medicine deals entered into by the world’s biopharma companies
• Detailed access to actual personalized medicine contracts enter into by the leading fifty bigpharma companies
• Insight into the terms included in a personalized medicine agreement, together with real world clause examples
• Understand the key deal terms companies have agreed in previous deals
• Undertake due diligence to assess suitability of your proposed deal terms for partner companies
Report scope
Personalized Medicine Partnering Terms and Agreements is intended to provide the reader with an in-depth understanding and access to personalized medicine trends and structure of deals entered into by leading companies worldwide.
Personalized Medicine Partnering Terms and Agreements includes:
o Trends in personalized medicine dealmaking in the biopharma industry since 2007
o Analysis of personalized medicine deal structure
o Access to headline, upfront, milestone and royalty data
o Case studies of real-life personalized medicine deals
o Access to over 1500 personalized medicine contract documents
o The leading personalized medicine deals by value since 2007
o Most active personalized medicine dealmakers since 2007
o The leading personalized medicine partnering resources
In Personalized Medicine Partnering Terms and Agreements, the available contracts are listed by:
o Company A-Z
o Headline value
o Stage of development at signing
o Deal component type
o Specific therapy target
Each deal title links via Weblink to an online version of the deal record and where available, the contract document, providing easy access to each contract document on demand.
The Personalized Medicine Partnering Terms and Agreements report provides comprehensive access to available deals and contract documents for over 1500 personalized medicine deals. Analyzing actual contract agreements allows assessment of the following:
o What are the precise personalized medicine rights granted or optioned?
o What is actually granted by the agreement to the partner company?
o What exclusivity is granted?
o What is the payment structure for the deal?
o How are sales and payments audited?
o What is the deal term?
o How are the key terms of the agreement defined?
o How are IPRs handled and owned?
o Who is responsible for commercialization?
o Who is responsible for development, supply, and manufacture?
o How is confidentiality and publication managed?
o How are disputes to be resolved?
o Under what conditions can the deal be terminated?
o What happens when there is a change of ownership?
o What sublicensing and subcontracting provisions have been agreed?
o Which boilerplate clauses does the company insist upon?
o Which boilerplate clauses appear to differ from partner to partner or deal type to deal type?
o Which jurisdiction does the company insist upon for agreement law?
Number of pages:
The report is comprised of 992 pages.
Therapy Industry
Table of contents
Executive Summary
Chapter 1 – Introduction
Chapter 2 – Trends in personalized medicine dealmaking
2.1. Introduction
2.2. Personalized medicine partnering over the years
2.2.1 Biomarker partnering over the years
2.2.2 Companion diagnostic partnering over the years
2.2.3 Pharmacogenomic partnering over the years
2.3. Bigpharma personalized medicine dealmaking activity
2.3.1 Bigpharma biomarker dealmaking activity
2.3.2 Bigpharma companion diagnostic dealmaking activity
2.3.3 Bigpharma pharmacogenomic dealmaking activity
2.4. Bigpharma not active in personalized medicine
2.4.1 Bigpharma not active in biomarker dealmaking
2.4.2 Bigpharma not active in companion diagnostics dealmaking
2.4.3 Bigpharma not active in pharmacogenomic dealmaking
2.5. Personalized medicine partnering by deal type
2.5.1 Biomarker partnering by deal type
2.5.2 Companion diagnostic partnering by deal type
2.5.3 Pharmacogenomic partnering by deal type
2.6. Personalized medicine partnering by disease type
2.6.1 Biomarker partnering by disease type
2.6.2 Companion diagnostic partnering by disease type
2.6.3 Pharmacogenomic partnering by disease type
2.7 Average deal terms for personalized medicine
2.7.1 Biomarker headline values
2.7.2 Biomarker upfront payments
2.7.3 Biomarker milestone payments
2.7.4 Biomarker royalty rates
2.8 Average deal terms for companion diagnostics
2.8.1 Companion diagnostic headline values
2.8.2 Companion diagnostic upfront payments
2.8.3 Companion diagnostic milestone payments
2.8.4 Companion diagnostic royalty rates
2.9 Average deal terms for pharmacogenomics
2.9.1 Pharmacogenomic headline values
2.9.2 Pharmacogenomic upfront payments
2.9.3 Pharmacogenomic milestone payments
2.9.4 Pharmacogenomic royalty rates
Chapter 3 – Leading biomarker deals
3.1. Introduction
3.2. Top biomarker deals by value
3.3. Top biomarker deals involving bigpharma
Chapter 4 – Leading companion diagnostic deals
4.1. Introduction
4.2. Top companion diagnostic deals by value
4.3. Top companion diagnostic deals involving bigpharma
Chapter 5 – Leading pharmacogenomic deals
5.1. Introduction
5.2. Top pharmacogenomics deals by value
5.3. Top pharmacogenomic deals involving bigpharma
Chapter 6 – Bigpharma personalized medicine deals
6.1. Introduction
6.2. How to use bigpharma personalized medicine partnering deals
6.3. Bigpharma personalized medicine partnering company profiles
Abbott
Actavis
Alcon Labs
Allergan
Amgen
Apotex
Astellas
AstraZeneca
Baxter International
Bayer
Biogen Idec
Boehringer Ingelheim
Bristol-Myers Squibb
Celgene
Cephalon
Chugai
CSL
Daiichi Sankyo
Dainippon Sumitomo
Eisai
Eli Lilly
Forest Laboratories
Genzyme
Gilead Sciences
GlaxoSmithKline
Hospira
Johnson & Johnson
Kyowa Hakko Kirin
Lundbeck
Menarini
Merck & Co
Merck KGaA
Mitsubishi Tanabe
Mylan
Novartis
Novo Nordisk
Nycomed Pharma
Otsuka
Pfizer
Roche
Sanofi
Servier
Shionogi
Shire
Stada
Takeda
Teva
UCB
Warner Chilcott
Watson
Chapter 7 – Biomarker dealmaking directory
7.1. Introduction
7.2. Company A-Z
7.3. By stage of development
Discovery
Preclinical
Phase I
Phase II
Phase III
Regulatory
Marketed
7.4. By deal type
Asset purchase
Bigpharma outlicensing
Co-development
Collaborative R&D
Co-market
Contract service
Co-promotion
CRADA
Cross-licensing
Development
Distribution
Equity purchase
Evaluation
Grant
Joint venture
Licensing
Manufacturing
Manufacturing - OEM
Marketing
Option
Promotion
Research
Settlement
Spin out
Sub-license
Supply
Termination
7.5. By therapy area
Cardiovascular
Central Nervous System
Dental
Dermatology
Gastrointestinal
Genetic disorders
Genitourinary
Hematology
Hospital care
Immunology
Infectives
Inflammatory
Metabolic
Musculoskeletal
Oncology
Respiratory
Chapter 8 – Companion diagnostic dealmaking directory
8.1. Introduction
8.2. Company A-Z
8.3. By stage of development
Discovery
Pre-clinical
Phase I
Phase II
Phase III
Registration
Marketed
8.4. By deal type
Asset purchase
Bigpharma outlicensing
Co-development
Collaborative R&D
Co-market
Contract service
Development
Distribution
Equity purchase
Evaluation
Grant
Licensing
Manufacturing
Marketing
Option
Research
Settlement
Spin out
Sub-license
Supply
Technology transfer
8.5. By therapy area
Cardiovascular
Central nervous system
Dental
Dermatology
Gastrointestinal
Genetic disorders
Genitourinary
Hematology
Hormonal disorders
Hospital care
Immunology
Infection
Inflammatory
Metabolic
Musculoskeletal
Oncology
Ophthalmics
Respiratory
Sensory organ
Chapter 9 – Pharmacogenomics dealmaking directory
9.1. Introduction
9.2. Company A-Z
9.3. By stage of development
Discovery
Pre-clinical
Phase I
Phase II
Phase III
Registration
Marketed
9.4. By deal type
Asset purchase
Bigpharma outlicensing
Co-development
Collaborative R&D
Co-market
Contract service
Development
Distribution
Equity purchase
Evaluation
Grant
Joint venture
Licensing
Manufacturing
Marketing
Option
Research
Supply
9.5. By therapy area
Cardiovascular
Central nervous system
Dental
Dermatology
Gastrointestinal
Genetic disorders
Genitourinary
Hematology
Hormonal disorders
Hospital care
Immunology
Infection
Inflammatory
Metabolic
Musculoskeletal
Oncology
Ophthalmics
Respiratory
Sensory organ
Chapter 10 – Personalized medicine partnering resource center
10.1. Online personalized medicine partnering
10.2. Personalized medicine partnering events
10.3. Further reading on personalized medicine dealmaking
Appendices
Appendix 1 – Deal type definitions
Appendix 2 – Example companion diagnostic partnering agreement
About Wildwood Ventures
Current Partnering
Current Agreements
Recent titles from CurrentPartnering
Order Form – Reports
Table of figures
Figure 1: Personalized medicine partnering since 2007
Figure 2: Biomarker partnering since 2007
Figure 3: Companion diagnostic partnering since 2007
Figure 4: Pharmacogenomic partnering since 2007
Figure 5: Bigpharma – top 50 – personalized medicine deals 2007 to 2011
Figure 6: Bigpharma personalized medicine deal frequency – 2007 to 2011
Figure 7: Bigpharma – top 50 – biomarker deals 2007 to 2011
Figure 8: Bigpharma biomarker deal frequency – 2007 to 2011
Figure 9: Bigpharma – top 50 – companion diagnostic deals 2007 to 2011
Figure 10: Bigpharma companion diagnostic deal frequency – 2007 to 2011
Figure 11: Bigpharma – top 50 – pharmacogenomic deals 2007 to 2011
Figure 12: Bigpharma pharmacogenomics deal frequency – 2007 to 2011
Figure 13: Inactive bigpharma in personalized medicine 2007-2011
Figure 14: Inactive bigpharma in biomarkers 2007-2011
Figure 15: Inactive bigpharma in companion diagnostic 2007-2011
Figure 16: Inactive bigpharma in pharmacogenomics - 2007-2011
Figure 17: Personalized medicine partnering by deal type since 2007
Figure 18: Biomarker partnering by deal type since 2007
Figure 19: Companion diagnositc partnering by deal type since 2007
Figure 20: Pharmacogenomics partnering by deal type since 2007
Figure 21: Personalized medicine partnering by disease type since 2007
Figure 22: Personalized medicine partnering by oncology target since 2007
Figure 23: Biomarker partnering by disease type since 2007
Figure 24: Biomarker partnering by oncology target since 2007
Figure 25: Companion diagnostic partnering by disease type since 2007
Figure 26: Companion diagnostic partnering by oncology target since 2007
Figure 27: Pharmacogenomics partnering by disease type since 2007
Figure 28: Pharmacogenomic partnering by oncology target since 2007
Figure 29: Biomarker deals with a headline value
Figure 30: Biomarker deal headline value distribution, US$million – 2007-2011 – Discovery stage
Figure 31: Biomarker deal headline value distribution, US$million – 2007-2011 – Discovery stage - detail
Figure 32: Biomarker deals with upfront payment values
Figure 33: Biomarker deals with milestone payments
Figure 34: Biomarker deals with royalty rates, %
Figure 35: Companion diagnostic deals with a headline value
Figure 36: Companion diagnostic deal headline value distribution, US$million
Figure 37: Companion diagnostic deal headline value distribution, US$million
Figure 38: Companion diagnostic deals with upfront payment values
Figure 39: Companion diagnostic deal upfront payment distribution, US$million
Figure 40: Companion diagnostic deals with milestone payments
Figure 41: Companion diagnostic deals with royalty rates, %
Figure 42: Pharmacogenomic deals with a headline value
Figure 43: Pharmacogenomic deal headline value distribution, US$million
Figure 44: Pharmacogenomic deals with upfront payment values
Figure 45: Pharmacogenomic deal upfront payment distribution, US$million
Figure 46: Pharmacogenomic deals with milestone payments
Figure 47: Top biomarker deals by value since 2007
Figure 48: Top biomarker deals signed by bigpharma value since 2007
Figure 49: Top companion diagnostic deals by value since 2007
Figure 50: Top companion diagnostic deals signed by bigpharma value since 2007
Figure 51: Top pharmacogenomic deals by value since 2007
Figure 52: Top pharmacogenomic deals signed by bigpharma value since 2007
Figure 53: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Cardiovascular)
Figure 54: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Central Nervous System)
Figure 55: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Dental)
Figure 56: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Dermatology)
Figure 57: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Gastrointestinal)
Figure 58: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Genetic disorders)
Figure 59: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Genitourinary)
Figure 60: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Hematology)
Figure 61: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Hospital care)
Figure 62: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Immunology)
Figure 63: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Infectives)
Figure 64: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Inflammatory)
Figure 65: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Metabolic)
Figure 66: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Musculoskeletal)
Figure 67: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Oncology)
Figure 68: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Respiratory)
Figure 69: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Cardiovascular)
Figure 70: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Central Nervous System)
Figure 71: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Dermatology)
Figure 72: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Gastrointestinal)
Figure 73: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Hematology)
Figure 74: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Hormonal)
Figure 75: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Hospital care)
Figure 76: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Immunology)
Figure 77: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Infectives)
Figure 78:Recent deals (Jan 2007 to Dec 2011) - By therapy area (Inflammatory)
Figure 79: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Metabolic)
Figure 80: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Musculoskeletal)
Figure 81: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Oncology)
Figure 82: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Ophthalmics)
Figure 83: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Cardiovascular)
Figure 84: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Central Nervous System)
Figure 85: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Gastrointestinal)
Figure 86: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Genetic disorders)
Figure 87: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Hematology)
Figure 88: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Hormonal)
Figure 89: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Hospital care)
Figure 90: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Immunology)
Figure 91: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Infectives)
Figure 92: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Inflammatory)
Figure 93: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Metabolic)
Figure 94: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Oncology)
Figure 95: Recent deals (Jan 2007 to Dec 2011) - By therapy area (Respiratory)
Figure 96: Online partnering resources
Figure 97: Forthcoming partnering events
Figure 98: Deal type definitions
Figure 99: Companion diagnostic partnering agreement between Roche, Rules-Based Medicine, and Psynova Neurotech, December 2009
