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World Collagen and HA-Based Biomaterials Industry

  • January 2015
  • -
  • Global Industry Analysts
  • -
  • 227 pages

This report analyzes the worldwide markets for Collagen and HA-Based Biomaterials in US$ Thousands by the following Product Segments: Collagen-based Biomaterials (Urinary Incontinence, Corneal Shields, Facial Aesthetic Dermal Fillers, Wound Dressings), and Hyaluronic Acid-based Biomaterials (Viscosupplements, Viscoelastics, and Facial Aesthetic Dermal Fillers). The report provides separate comprehensive analytics for the US, Canada, Japan, Europe, Asia-Pacific, and Rest of World. Annual estimates and forecasts are provided for the period 2013 through 2020. Also, a seven-year historic analysis is provided for these markets. Market data and analytics are derived from primary and secondary research. Company profiles are primarily based on public domain information including company URLs. The report profiles 55 companies including many key and niche players such as -

Abbott Medical Optics, Inc.
Alcon Laboratories, Inc.
Allergan, Inc.
Anika Therapeutics, Inc.
Bausch & Lomb, Inc.

Table Of Contents

World Collagen and HA-Based Biomaterials Industry



I. INTRODUCTION, METHODOLOGY and PRODUCT DEFINITIONS
Study Reliability and Reporting Limitations I-1
Disclaimers I-2
Data Interpretation and Reporting Level I-2
Quantitative Techniques and Analytics I-3
Product Definitions and Scope of Study I-3
Product Definitions I-4
Collagen-based Biomaterials I-4
Urinary Incontinence I-4
Corneal Shields I-4
Facial Aesthetic Dermal Fillers I-4
Wound Dressings I-4
Hyaluronic Acid (HA)-based Biomaterials I-4
Viscosupplements I-4
Viscoelastics I-4
Facial Aesthetic Dermal Fillers I-5


II. EXECUTIVE SUMMARY

1. GLOBAL MARKET OVERVIEW II-1
Outlook II-1
Review of Major Segments II-1
Collagen-Based Biomaterials II-1
Urinary Incontinence Products II-1
Corneal Shields II-2
Facial Aesthetic Dermal fillers II-2
Wound Dressings II-2
Hyaluronic Acid-based Biomaterials II-2
Viscosupplementation II-3
HA-based Viscoelastics market II-3
Table 1: Recent Past, Current and Future Analysis of
Cataract Procedures Worldwide Analyzed in terms of Number
of Procedures in Millions for Years 2010 through 2018
(includes corresponding Graph/Chart) II-3
Facial Aesthetic Dermal Fillers II-4
Select HA-Based Products in the Global Market II-4
Regional Perspective II-4
Growth Drivers- At a Glance II-4
Challenges Faced II-5
Biomaterials Face Competition II-5
Competitive Scenario II-5
Leading Players in the Worldwide Collagen and HA-Based
Biomaterials Market II-6
Table 2: Global Viscosupplements Market (2013): Market Share
Breakdown of Sales in Percentage for Genzyme and Others
(includes corresponding Graph/Chart) II-6
Burgeoning Global Population Offers Significant Growth
Opportunities II-7
Table 3: Top 25 Countries Worldwide in Terms of Population
(2010 and 2013) (includes corresponding Graph/Chart) II-7
Aging Global Population: Need for New Effective Treatments II-8
Table 4: Global Population Statistics for the 65+ Age Group
(2012) (includes corresponding Graph/Chart) II-9
Rising Disposable Income: Another Favorable Factor II-10
Table 5: Annual Disposable Incomes in US$ ‘000 for Select
Countries (2012) (includes corresponding Graph/Chart) II-10
Longer Life Expectancy Bolsters Market Growth II-11
Table 6: Life Expectancy for Select Countries in Number of
Years (2013) (includes corresponding Graph/Chart) II-11

Table 7: Life Expectancy at Age 60 and 80 Years- (2010-2015),
(2020-2025) and (2045-2050) (includes corresponding
Graph/Chart) II-12
Orthobiologics - A Thriving Market II-12
Table 8: Global Orthobiologics Market (2012): Percentage
Share Breakdown of Value Sales for Viscosupplements,
Allograft and DBM, Hemostasis, Synthetic Bone Graft
Substitutes, Growth Factors, and Blood and Marrow-based
Products (includes corresponding Graph/Chart) II-13
Chronic Wounds and Healthcare Burden II-14
Wound Care Biologics Gain Prominence with Bioactive Products II-14
Prevalence and Incidence of Wounds - Select Statistics II-15
Table 9: Global Prevalence of Wounds (2013) (includes
corresponding Graph/Chart) II-15

Table 10: Global Wound Care Market (2014): Percentage
Breakdown of Share by Wound Type (includes corresponding
Graph/Chart) II-15
World Collagen-based Wound Care Products Market (2014) -
Select Products and Manufacturers II-15

2. MARKET TRENDS AND ISSUES II-16
Increasing Preference for Shorter and Convenient Treatment
Options II-16
Manufacturers Target Private Healthcare Market II-16
Population/Baby Boomers Play a Major Role II-16
Injectables Market on a High Growth Curve II-16
Collagen-based Bioengineered Alternatives to Bone Grafts II-17
Skin Care Products Continue to Dominate Cosmeceuticals II-17
Hyaluronic-Acid Based Products Replace Other Facial Implant
Products II-18
Biomaterial Research Develops New Applications II-18
Hyaluronic Acid Applications in Medical Aesthetics II-18
Issues and Threats II-19
Potential Shortage of Biomaterials II-19
Inadequate Reimbursements II-19

3. BIOMATERIALS - A BRIEF OVERVIEW II-20
Definition II-20
Types of Biomaterials for Medical Devices II-20
Polymers II-20
Composites II-20
Metals and Alloys II-20
Ceramics II-21
Biological Biomaterials II-21
Application of Various Forms of Biomaterials II-21
Collagen and Ha-Based Biomaterials II-21
Collagen Based Biomaterials II-22
What is Collagen? II-22
Collagen-based Biomaterials II-22
Various Forms of Collagen and Applications II-23
Soft Tissue Fillers Offer Patients More Options II-23
Threatened by Alternatives II-23
Hyaluronic Acid (HA) II-23
Table 11: HA Distribution in the Body (includes
corresponding Graph/Chart) II-24
Properties of HA II-24

4. SEGMENT OVERVIEW II-25
Collagen Based Products II-25
Urinary Incontinence Implants II-25
Classification of Urinary Incontinence II-25
Stress Incontinence II-25
Urge Incontinence II-25
Overflow Incontinence II-25
Functional Incontinence II-26
Treatment of Urinary Incontinence II-26
Periurethral Injections (Collagen Injections) II-26
Collagen Corneal Shields II-26
Research Proceedings II-27
Application of Collagen Shields II-27
Ocular Surface Lubrication II-27
Ocular Surface Protection II-27
Drug Delivery II-27
Wound Healing II-27
Facial Aesthetic Dermal fillers II-27
Functions of Collagen-based Facial Implants II-28
Aesthetic Dermal fillers - Playing a Major Role II-28
Normal Skin Changes Associated with Aging II-28
Collagen Injections as Facial Implants II-28
Wound Dressings II-28
Leading Players in the Collagen-based Wound Dressings Market II-29
Global Wound Care Market Flaunts Steady Growth II-29
Other Applications of Collagen II-30
Collagen Gene Delivery Systems II-30
Collagen as Bone Graft Substitution II-30
Artificial Skin II-30
Hyaluronic Acid Based Biomaterials II-30
Viscosupplementation II-31
Hyaluronic Acid as Viscosupplement II-31
Viscosupplementation Treatment for Osteoarthritis II-31
Major Hyaluronic Acid Based Viscosupplements II-31
Viscoelastics II-31
Facial Aesthetic Dermal fillers II-32
Commercially Available HA Soft Tissue Fillers II-32
Review of Select HA based Aesthetic Dermal Implant Products II-32
Advantages of HA Based Products Over Collagen Products II-32
Vesicoureteral Reflux Implants II-33
Botox - A Competing Biomaterial II-33

5. PRODUCT INTRODUCTIONS/INNOVATIONS II-34
Anika Launches Monovisc® for Osteoarthritis II-34
Invibio Biomaterial Solution Introduces PEEK-OPTIMA Polymer II-34
Zimmer Holdings Introduces Gel-One® Injectable Gel II-34
Innocoll Completes Phase 2 Studies of XaraColl® II-34

6. RECENT INDUSTRY ACTIVITY II-35
Royal DSM Takes Over Kensey Nash II-35
Angel Biotechnology Holdings Acquires Specific Assets of
Collagen and Biomaterial Manufacturing Business II-35
Innocoll Signs License and Distribution Agreement with Inresa
Arzneimittel and Flynn Pharma II-35
ConvaTec Acquires Trio Healthcare International II-35
ConvaTec Holdings UK Acquires SureCalm Healthcare Holdings II-35
Mölnlycke Health Care US Takes Over Burn and Wound Care
Division of Brennen Medical II-35
Systagenix Takes Over O2 Insights II-36
Novozymes Begins Supply of Hyaluronic Acid II-36

7. FOCUS ON SELECT KEY PLAYERS II-37
Abbott Medical Optics, Inc. (US) II-37
Alcon Laboratories, Inc. (US) II-37
Allergan, Inc. (US) II-38
Anika Therapeutics, Inc. (US) II-38
Bausch and Lomb, Inc. (US) II-38
Collagen Solutions Plc. (UK) II-39
Galderma (Switzerland) II-39
Genzyme (US) II-39
Lifecore Biomedical, LLC (US) II-40
Seikagaku Corp. (Japan) II-40
Teijin Pharma Limited (Japan) II-41

8. GLOBAL MARKET PERSPECTIVE II-42
Table 12: World Recent Past, Current and Future Analysis for
Collagen and HA-Based Biomaterials by Geographic Region - US,
Canada, Japan, Europe, Asia-Pacific, and Rest of World Markets
Independently Analyzed with Annual Sales Figures in US$
Thousand for Years 2013 through 2020 (includes corresponding
Graph/Chart) II-42

Table 13: World Historic Review for Collagen and HA-Based
Biomaterials by Geographic Region - US, Canada, Japan, Europe,
Asia-Pacific, and Rest of World Markets Independently Analyzed
with Annual Sales Figures in US$ Thousand for Years 2006
through 2012 (includes corresponding Graph/Chart) II-43

Table 14: World 15-Year Perspective for Collagen and HA-Based
Biomaterials by Geographic Region - Percentage Breakdown of
Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific, and
Rest of World Markets for Years 2006, 2014 and 2020 (includes
corresponding Graph/Chart) II-44
Collagen and HA-Based Biomaterials Market by Product Group/
Segment II-45
Collagen-based Biomaterials Market by Region II-45
Table 15: World Recent Past, Current and Future Analysis for
Collagen Based Biomaterials by Geographic Region - US,
Canada, Japan, Europe, Asia-Pacific, and Rest of World
Markets Independently Analyzed with Annual Sales Figures in
US$ Thousand for Years 2013 through 2020 (includes
corresponding Graph/Chart) II-45

Table 16: World Historic Review for Collagen Based
Biomaterials by Geographic Region - US, Canada, Japan,
Europe, Asia-Pacific, and Rest of World Markets
Independently Analyzed with Annual Sales Figures in US$
Thousand for Years 2006 through 2012 (includes corresponding
Graph/Chart) II-46

Table 17: World 15-Year Perspective for Collagen Based
Biomaterials by Geographic Region - Percentage Breakdown of
Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific,
and Rest of World Markets for Years 2006, 2014 and 2020
(includes corresponding Graph/Chart) II-47

Table 18: World Recent Past, Current and Future Analysis for
Collagen-based Urinary Incontinence Products by Geographic
Region - US, Canada, Japan, Europe, Asia-Pacific, and Rest
of World Markets Independently Analyzed with Annual Sales
Figures in US$ Thousand for Years 2013 through 2020
(includes corresponding Graph/Chart) II-48

Table 19: World Historic Review for Collagen-based Urinary
Incontinence Products by Geographic Region - US, Canada,
Japan, Europe, Asia-Pacific, and Rest of World Markets
Independently Analyzed with Annual Sales Figures in US$
Thousand for Years 2006 through 2012 (includes corresponding
Graph/Chart) II-49

Table 20: World 15-Year Perspective for Collagen-based
Urinary Incontinence Products by Geographic Region -
Percentage Breakdown of Dollar Sales for US, Canada, Japan,
Europe, Asia-Pacific, and Rest of World Markets for Years
2006, 2014 and 2020 (includes corresponding Graph/Chart) II-50

Table 21: World Recent Past, Current and Future Analysis for
Collagen-based Corneal Shields by Geographic Region - US,
Canada, Japan, Europe, Asia-Pacific, and Rest of World
Markets Independently Analyzed with Annual Sales Figures in
US$ Thousand for Years 2013 through 2020 (includes
corresponding Graph/Chart) II-51

Table 22: World Historic Review for Collagen-based Corneal
Shields by Geographic Region - US, Canada, Japan, Europe,
Asia-Pacific, and Rest of World Markets Independently
Analyzed with Annual Sales Figures in US$ Thousand for Years
2006 through 2012 (includes corresponding Graph/Chart) II-52

Table 23: World 15-Year Perspective for Collagen-based
Corneal Shields by Geographic Region - Percentage Breakdown
of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific,
and Rest of World Markets for Years 2006, 2014 and 2020
(includes corresponding Graph/Chart) II-53

Table 24: World Recent Past, Current and Future Analysis for
Collagen-based Facial Aesthetic Dermal Fillers by Geographic
Region - US, Canada, Japan, Europe, Asia-Pacific, and Rest
of World Markets Independently Analyzed with Annual Sales
Figures in US$ Thousand for Years 2013 through 2020
(includes corresponding Graph/Chart) II-54

Table 25: World Historic Review for Collagen-based Facial
Aesthetic Dermal Fillers by Geographic Region - US, Canada,
Japan, Europe, Asia-Pacific, and Rest of World Markets
Independently Analyzed with Annual Sales Figures in US$
Thousand for Years 2006 through 2012 (includes corresponding
Graph/Chart) II-55

Table 26: World 15-Year Perspective for Collagen-based
Facial Aesthetic Dermal Fillers by Geographic Region -
Percentage Breakdown of Dollar Sales for US, Canada, Japan,
Europe, Asia-Pacific, and Rest of World Markets for Years
2006, 2014 and 2020 (includes corresponding Graph/Chart) II-56

Table 27: World Recent Past, Current and Future Analysis for
Collagen-based Wound Dressings by Geographic Region - US,
Canada, Japan, Europe, Asia-Pacific, and Rest of World
Markets Independently Analyzed with Annual Sales Figures in
US$ Thousand for Years 2013 through 2020 (includes
corresponding Graph/Chart) II-57

Table 28: World Historic Review for Collagen-based Wound
Dressings by Geographic Region - US, Canada, Japan, Europe,
Asia-Pacific, and Rest of World Markets Independently
Analyzed with Annual Sales Figures in US$ Thousand for Years
2006 through 2012 (includes corresponding Graph/Chart) II-58

Table 29: World 15-Year Perspective for Collagen-based Wound
Dressings by Geographic Region - Percentage Breakdown of
Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific,
and Rest of World Markets for Years 2006, 2014 and 2020
(includes corresponding Graph/Chart) II-59
Hyaluronic Acid Based Biomaterials Market by Geographic Region II-60
Table 30: World Recent Past, Current and Future Analysis for
Hyaluronic Acid Based Biomaterials by Geographic Region -
US, Canada, Japan, Europe, Asia-Pacific, and Rest of World
Markets Independently Analyzed with Annual Sales Figures in
US$ Thousand for Years 2013 through 2020 (includes
corresponding Graph/Chart) II-60

Table 31: World Historic Review for Hyaluronic Acid Based
Biomaterials by Geographic Region - US, Canada, Japan,
Europe, Asia-Pacific, and Rest of World Markets
Independently Analyzed with Annual Sales Figures in US$
Thousand for Years 2006 through 2012 (includes corresponding
Graph/Chart) II-61

Table 32: World 15-Year Perspective for Hyaluronic Acid
Based Biomaterials by Geographic Region - Percentage
Breakdown of Dollar Sales for US, Canada, Japan, Europe,
Asia-Pacific, and Rest of World Markets for Years 2006, 2014 and
2020 (includes corresponding Graph/Chart) II-62

Table 33: World Recent Past, Current and Future Analysis for
Hyaluronic Acid Based Viscosupplements by Geographic Region -
US, Canada, Japan, Europe, Asia-Pacific, and Rest of World
Markets Independently Analyzed with Annual Sales Figures in
US$ Thousand for Years 2013 through 2020 (includes
corresponding Graph/Chart) II-63

Table 34: World Historic Review for Hyaluronic Acid Based
Viscosupplements by Geographic Region - US, Canada, Japan,
Europe, Asia-Pacific, and Rest of World Markets
Independently Analyzed with Annual Sales Figures in US$
Thousand for Years 2006 through 2012 (includes corresponding
Graph/Chart) II-64

Table 35: World 15-Year Perspective for Hyaluronic Acid
Based Viscosupplements by Geographic Region - Percentage
Breakdown of Dollar Sales for US, Canada, Japan, Europe,
Asia-Pacific, and Rest of World Markets for Years 2006, 2014 and
2020 (includes corresponding Graph/Chart) II-65

Table 36: World Recent Past, Current and Future Analysis for
Hyaluronic Acid Based Viscoelastics by Geographic Region -
US, Canada, Japan, Europe, Asia-Pacific, and Rest of World
Markets Independently Analyzed with Annual Sales Figures in
US$ Thousand for Years 2013 through 2020 (includes
corresponding Graph/Chart) II-66

Table 37: World Historic Review for Hyaluronic Acid Based
Viscoelastics by Geographic Region - US, Canada, Japan,
Europe, Asia-Pacific, and Rest of World Markets
Independently Analyzed with Annual Sales Figures in US$
Thousand for Years 2006 through 2012 (includes corresponding
Graph/Chart) II-67

Table 38: World 15-Year Perspective for Hyaluronic Acid
Based Viscoelastics by Geographic Region - Percentage
Breakdown of Dollar Sales for US, Canada, Japan, Europe,
Asia-Pacific, and Rest of World Markets for Years 2006, 2014 and
2020 (includes corresponding Graph/Chart) II-68

Table 39: World Recent Past, Current and Future Analysis for
Hyaluronic Acid Based Facial Aesthetic Dermal Fillers by
Geographic Region - US, Canada, Japan, Europe, Asia-Pacific,
and Rest of World Markets Independently Analyzed with Annual
Sales Figures in US$ Thousand for Years 2013 through 2020
(includes corresponding Graph/Chart) II-69

Table 40: World Historic Review for Hyaluronic Acid Based
Facial Aesthetic Dermal Fillers by Geographic Region - US,
Canada, Japan, Europe, Asia-Pacific, and Rest of World
Markets Independently Analyzed with Annual Sales Figures in
US$ Thousand for Years 2006 through 2012 (includes
corresponding Graph/Chart) II-70

Table 41: World 15-Year Perspective for Hyaluronic Acid
Based Facial Aesthetic Dermal Fillers by Geographic Region -
Percentage Breakdown of Dollar Sales for US, Canada, Japan,
Europe, Asia-Pacific, and Rest of World Markets for Years
2006, 2014 and 2020 (includes corresponding Graph/Chart) II-71


III. MARKET

1. THE UNITED STATES III-1
A.Market Analysis III-1
US - The Largest Biomaterials Market Globally III-1
Market Trends III-1
Facial Aesthetics Market Grows in Popularity III-1
Growing Number of Cosmetic Procedures to Boost Sales III-2
Rising Demand for Non-Surgical Cosmetic Procedures in the US III-2
US Facial Aesthetic Dermal Fillers Open Doors for New Players III-2
Market Outlook by Segment III-2
Collagen Based Biomaterials III-2
Urinary Incontinence Products III-2
Corneal Shields III-3
Facial Aesthetic Dermal Fillers Market - Highly Competitive III-3
Wound Dressings Market III-3
Table 42: The US Biologic Wound Dressings Market by
Leading Player (2013): Percentage Share Breakdown for
Integra, MiMedx, Organogenesis, Shire, Smith and Nephew,
and Others (includes corresponding Graph/Chart) III-3
HA Based Biomaterials III-3
Viscosupplements III-3
Growth Drivers - At a Glance III-4
Aging Population: A Strong Demographic Driver III-4
Table 43: North American Elderly Population by Age Group
(1975-2050) (includes corresponding Graph/Chart) III-5

Table 44: The US Population Breakdown by Age Group
(2012) (includes corresponding Graph/Chart) III-5
Rising Obesity Prevalence: Increases the Risk of
Osteoarthritis III-6
Table 45: Obesity Prevalence in US Adults by Type of
Obesity (2013) (includes corresponding Graph/Chart) III-6

Table 46: The US Obesity Prevalence by Age Group (2013)
(includes corresponding Graph/Chart) III-6
Growing Incidence of Osteoarthritis Drives
Viscosupplements Market III-6
Table 47: Population Diagnosed with Arthritis in the US
by Age Group (In %) (includes corresponding Graph/Chart) III-7
Hyaluronic Acid Knee Procedures on the Rise III-7
Table 48: US Viscosupplement Patient Share (2013):
Percentage Breakdown of Osteoarthritis Patient Share for
Viscosupplement Treated and Untreated Patients (includes
corresponding Graph/Chart) III-8
Growing Patient Awareness Fuels Demand for Hyaluronic-
Acid Viscosupplements III-8
Off-Label Use of Viscosupplement products on the Rise III-8
Leading Players III-8
Table 49: The US Hyaluronic Acid-based Viscosupplements
Market by Leading Player (2013): Market Share Breakdown
by Value Sales in Percentage for Genzyme/Sanofi, and
Others (includes corresponding Graph/Chart) III-9

Table 50: The US Viscosupplements Market by Leading
Brands (2013): Market Share Breakdown of Value Sales in
Percentage for Synvisc One, Synvisc, and Others
(includes corresponding Graph/Chart) III-9
Viscoelastics III-9
A Snapshot of US Demographic Profile and Cataracts III-10
Table 51: Cataract Prevalence in the US by Age Group
(includes corresponding Graph/Chart) III-10
Leading Players III-10
Table 52: The US Hyaluronic Acid-based Viscoelastics
Market by Leading Players (2013): Market Share Breakdown
by Value Sales in Percentage for Alcon, Abbott, Bausch and
Lomb, and Others (includes corresponding Graph/Chart) III-10
Dermal Fillers -The Fastest Growing Segment III-10
Competition III-11
Product Launches III-11
Strategic Corporate Developments III-12
Focus on Select Players III-12
B.Market Analytics III-16
Table 53: The US Recent Past, Current and Future Analysis for
Collagen and HA-based Biomaterials by Product Group/Segment -
Collagen Based Biomaterials (Urinary Incontinence
Products, Corneal Shields, Facial Aesthetic Dermal Fillers
and Wound Dressings); and Hyaluronic Acid Based Biomaterials
(Viscosupplements, Viscoelastics and Facial Aesthetic Dermal
Fillers) Markets Independently Analyzed with Annual Sales
Figures in US$ Thousand for Years 2013 through 2020
(includes corresponding Graph/Chart) III-16

Table 54: The US Historic Review for Collagen and HA-based
Biomaterials by Product Group/Segment - Collagen Based
Biomaterials (Urinary Incontinence Products, Corneal
Shields, Facial Aesthetic Dermal Fillers and Wound
Dressings); and Hyaluronic Acid Based Biomaterials
(Viscosupplements, Viscoelastics and Facial Aesthetic Dermal
Fillers) Markets Independently Analyzed with Annual Sales
Figures in US$ Thousand for Years 2006 through 2012
(includes corresponding Graph/Chart) III-17

Table 55: The US 15-Year Perspective for Collagen and
HA-based Biomaterials by Product Segment - Percentage
Breakdown of Dollar Sales for Collagen Based Biomaterials
(Urinary Incontinence Products, Corneal Shields, Facial
Aesthetic Dermal Fillers and Wound Dressings); and
Hyaluronic Acid Based Biomaterials (Viscosupplements,
Viscoelastics and Facial Aesthetic Dermal Fillers) Markets
for Years 2006, 2014 and 2020 (includes corresponding
Graph/Chart) III-18

2. CANADA III-19
Market Analysis III-19
Table 56: Canadian Recent Past, Current and Future Analysis
for Collagen and HA-based Biomaterials by Product
Group/Segment - Collagen Based Biomaterials (Urinary
Incontinence Products, Corneal Shields, Facial Aesthetic
Dermal Fillers and Wound Dressings); and Hyaluronic Acid
Based Biomaterials (Viscosupplements, Viscoelastics and
Facial Aesthetic Dermal Fillers) Markets Independently
Analyzed with Annual Sales Figures in US$ Thousand for Years
2013 through 2020 (includes corresponding Graph/Chart) III-20

Table 57: Canadian Historic Review for Collagen and HA-based
Biomaterials by Product Group/ Segment - Collagen Based
Biomaterials (Urinary Incontinence Products, Corneal
Shields, Facial Aesthetic Dermal Fillers and Wound
Dressings); and Hyaluronic Acid Based Biomaterials
(Viscosupplements, Viscoelastics and Facial Aesthetic Dermal
Fillers) Markets Independently Analyzed with Annual Sales
Figures in US$ Thousand for Years 2006 through 2012
(includes corresponding Graph/Chart) III-21

Table 58: Canadian 15-Year Perspective for Collagen and
HA-based Biomaterials by Product Segment - Percentage
Breakdown of Dollar Sales for Collagen Based Biomaterials
(Urinary Incontinence Products, Corneal Shields, Facial
Aesthetic Dermal Fillers and Wound Dressings); and
Hyaluronic Acid Based Biomaterials (Viscosupplements,
Viscoelastics and Facial Aesthetic Dermal Fillers) Markets
for Years 2006, 2014 and 2020 (includes corresponding
Graph/Chart) III-22

3. JAPAN III-23
A.Market Analysis III-23
Graying Population Spurs Growth of Collagen and HA-Based
Biomaterials III-23
Table 59: Japanese Elderly (65+ Years) Population:
2000-2020 (includes corresponding Graph/Chart) III-23
HA-based Viscosupplement Treatment - Highly Popular in Japan III-23
Competitors III-24
Collagen-based Biomaterials III-24
Select Key Players III-24
B.Market Analytics III-25
Table 60: Japanese Recent Past, Current and Future Analysis
for Collagen and HA-based Biomaterials by Product
Group/Segment - Collagen Based Biomaterials (Urinary
Incontinence Products, Corneal Shields, Facial Aesthetic
Dermal Fillers and Wound Dressings); and Hyaluronic Acid
Based Biomaterials (Viscosupplements, Viscoelastics and
Facial Aesthetic Dermal Fillers) Markets Independently
Analyzed with Annual Sales Figures in US$ Thousand for Years
2013 through 2020 (includes corresponding Graph/Chart) III-25

Table 61: Japanese Historic Review for Collagen and HA-based
Biomaterials by Product Group/ Segment - Collagen Based
Biomaterials (Urinary Incontinence Products, Corneal
Shields, Facial Aesthetic Dermal Fillers and Wound
Dressings); and Hyaluronic Acid Based Biomaterials
(Viscosupplements, Viscoelastics and Facial Aesthetic Dermal
Fillers) Markets Independently Analyzed with annual Sales
Figures in US$ Thousand for Years 2006 through 2012
(includes corresponding Graph/Chart) III-26

Table 62: Japanese 15-Year Perspective for Collagen and
HA-based Biomaterials by Product Segment - Percentage
Breakdown of Dollar Sales for Collagen Based Biomaterials
(Urinary Incontinence Products, Corneal Shields, Facial
Aesthetic Dermal Fillers and Wound Dressings); and
Hyaluronic Acid Based Biomaterials (Viscosupplements,
Viscoelastics and Facial Aesthetic Dermal Fillers) Markets
for Years 2006, 2014 and 2020 (includes corresponding
Graph/Chart) III-27

4. EUROPE III-28
A.Market Analysis III-28
A Key Market in the Advanced Wound Care Sector III-28
Viscosupplement Market III-28
Competitive Scenario III-29
Table 63: European Viscosupplementation Products Market by
Leading Players (2013): Market Share Breakdown by Value
Sales in Percentage for Curasan, Fidia, Genzyme,
Seikagaku, and Others (includes corresponding Graph/Chart) III-29
Ageing Population Boosts Demand III-30
Table 64: European Country-wise Statistics of 60+
Population as % of Total Population: 2013 (includes
corresponding Graph/Chart) III-30
The Impact of Euro Zone Crisis on HA-based Biomaterials Market III-31
Viscosupplement Market III-31
Viscoelastics Market III-31
Aesthetic Dermal Fillers Market III-31
B.Market Analytics III-32
Table 65: European Recent Past, Current and Future Analysis
for Collagen and HA-Based Biomaterials by Geographic Region -
France, Germany, Italy, UK, Spain, Russia, and Rest of
Europe Markets Independently Analyzed with Annual Sales
Figures in US$ Thousand for Years 2013 through 2020
(includes corresponding Graph/Chart) III-32

Table 66: European Historic Review for Collagen and HA-Based
Biomaterials by Geographic Region - France, Germany, Italy,
UK, Spain, Russia, and Rest of Europe Markets Independently
Analyzed with Annual Sales Figures in US$ Thousand for Years
2006 through 2012 (includes corresponding Graph/Chart) III-33

Table 67: European 15-Year Perspective for Collagen and
HA-Based Biomaterials by Geographic Region - Percentage
Breakdown of Dollar Sales for France, Germany, Italy, UK,
Spain, Russia, and Rest of Europe Markets for Years 2006, 2014 and
2020 (includes corresponding Graph/Chart) III-34

Table 68: European Recent Past, Current and Future Analysis
for Collagen and HA-based Biomaterials by Product
Group/Segment - Collagen Based Biomaterials (Urinary
Incontinence Products, Corneal Shields, Facial Aesthetic
Dermal Fillers and Wound Dressings); and Hyaluronic Acid
Based Biomaterials (Viscosupplements, Viscoelastics and
Facial Aesthetic Dermal Fillers) Markets Independently
Analyzed with Annual Sales Figures in US$ Thousand for Years
2013 through 2020 (includes corresponding Graph/Chart) III-35

Table 69: European Historic Review for Collagen and HA-based
Biomaterials by Product Group/Segment - Collagen Based
Biomaterials (Urinary Incontinence Products, Corneal
Shields, Facial Aesthetic Dermal Fillers and Wound
Dressings); and Hyaluronic Acid Based Biomaterials
(Viscosupplements, Viscoelastics and Facial Aesthetic Dermal
Fillers) Markets Independently Analyzed with Annual Sales
Figures in US$ Thousand for Years 2006 through 2012
(includes corresponding Graph/Chart) III-36

Table 70: European 15-Year Perspective for Collagen and
HA-based Biomaterials by Product Segment - Percentage
Breakdown of Dollar Sales for Collagen Based Biomaterials
(Urinary Incontinence Products, Corneal Shields, Facial
Aesthetic Dermal Fillers and Wound Dressings); and
Hyaluronic Acid Based Biomaterials (Viscosupplements,
Viscoelastics and Facial Aesthetic Dermal Fillers) Markets
for Years 2006, 2014 and 2020 (includes corresponding
Graph/Chart) III-37

4a. FRANCE III-38
A.Market Analysis III-38
Sanofi Sa (France) - A Key Player III-38
B.Market Analytics III-39
Table 71: French Recent Past, Current and Future Analysis for
Collagen and HA-based Biomaterials by Product Group/Segment -
Collagen Based Biomaterials (Urinary Incontinence
Products, Corneal Shields, Facial Aesthetic Dermal Fillers
and Wound Dressings); and Hyaluronic Acid Based Biomaterials
(Viscosupplements, Viscoelastics and Facial Aesthetic Dermal
Fillers) Markets Independently Analyzed with Annual Sales
Figures in US$ Thousand for Years 2013 through 2020
(includes corresponding Graph/Chart) III-39

Table 72: French Historic Review for Collagen and HA-based
Biomaterials by Product Group/ Segment - Collagen Based
Biomaterials (Urinary Incontinence Products, Corneal
Shields, Facial Aesthetic Dermal Fillers and Wound
Dressings); and Hyaluronic Acid Based Biomaterials
(Viscosupplements, Viscoelastics and Facial Aesthetic Dermal
Fillers) Markets Independently Analyzed with Annual Sales
Figures in US$ Thousand for Years 2006 through 2012
(includes corresponding Graph/Chart) III-40

Table 73: French 15-Year Perspective for Collagen and
HA-based Biomaterials by Product Segment - Percentage
Breakdown of Dollar Sales for Collagen Based Biomaterials
(Urinary Incontinence Products, Corneal Shields, Facial
Aesthetic Dermal Fillers and Wound Dressings); and
Hyaluronic Acid Based Biomaterials (Viscosupplements,
Viscoelastics and Facial Aesthetic Dermal Fillers) Markets
for Years 2006, 2014 and 2020 (includes corresponding
Graph/Chart) III-41

4b. GERMANY III-42
A.Market Analysis III-42
5-Injection HA Products - Market with High Potential III-42
B.Market Analytics III-43
Table 74: German Recent Past, Current and Future Analysis for
Collagen and HA-based Biomaterials by Product Group/Segment -
Collagen Based Biomaterials (Urinary Incontinence
Products, Corneal Shields, Facial Aesthetic Dermal Fillers
and Wound Dressings); and Hyaluronic Acid Based Biomaterials
(Viscosupplements, Viscoelastics and Facial Aesthetic Dermal
Fillers) Markets Independently Analyzed with Annual Sales
Figures in US$ Thousand for Years 2013 through 2020
(includes corresponding Graph/Chart) III-43

Table 75: German Historic Review for Collagen and HA-based
Biomaterials by Product Group/ Segment - Collagen Based
Biomaterials (Urinary Incontinence Products, Corneal
Shields, Facial Aesthetic Dermal Fillers and Wound
Dressings); and Hyaluronic Acid Based Biomaterials
(Viscosupplements, Viscoelastics and Facial Aesthetic Dermal
Fillers) Markets Independently Analyzed with Annual Sales
Figures in US$ Thousand for Years 2006 through 2012
(includes corresponding Graph/Chart) III-44

Table 76: German 15-Year Perspective for Collagen and
HA-based Biomaterials by Product Segment - Percentage
Breakdown of Dollar Sales for Collagen Based Biomaterials
(Urinary Incontinence Products, Corneal Shields, Facial
Aesthetic Dermal Fillers and Wound Dressings); and
Hyaluronic Acid Based Biomaterials (Viscosupplements,
Viscoelastics and Facial Aesthetic Dermal Fillers) Markets
for Years 2006, 2014 and 2020 (includes corresponding
Graph/Chart) III-45

4c. ITALY III-46
Market Analysis III-46
Table 77: Italian Recent Past, Current and Future Analysis for
Collagen and HA-based Biomaterials by Product Group/Segment -
Collagen Based Biomaterials (Urinary Incontinence
Products, Corneal Shields, Facial Aesthetic Dermal Fillers
and Wound Dressings); and Hyaluronic Acid Based Biomaterials
(Viscosupplements, Viscoelastics and Facial Aesthetic Dermal
Fillers) Markets Independently Analyzed with Annual Sales
Figures in US$ Thousand for Years 2013 through 2020
(includes corresponding Graph/Chart) III-47

Table 78: Italian Historic Review for Collagen and HA-based
Biomaterials by Product Group/Segment - Collagen Based
Biomaterials (Urinary Incontinence Products, Corneal
Shields, Facial Aesthetic Dermal Fillers and Wound
Dressings); and Hyaluronic Acid Based Biomaterials
(Viscosupplements, Viscoelastics and Facial Aesthetic Dermal
Fillers) Markets Independently Analyzed with Annual Sales
Figures in US$ Thousand for Years 2006 through 2012
(includes corresponding Graph/Chart) III-48

Table 79: Italian 15-Year Perspective for Collagen and
HA-based Biomaterials by Product Segment - Percentage
Breakdown of Dollar Sales for Collagen Based Biomaterials
(Urinary Incontinence Products, Corneal Shields, Facial
Aesthetic Dermal Fillers and Wound Dressings); and
Hyaluronic Acid Based Biomaterials (Viscosupplements,
Viscoelastics and Facial Aesthetic Dermal Fillers) Markets
for Years 2006, 2014 and 2020 (includes corresponding
Graph/Chart) III-49

4d. THE UNITED KINGDOM III-50
A.Market Analysis III-50
Product Launch III-50
Strategic Corporate Developments III-50
Collagen Solutions Plc - A Key UK Player III-51
B.Market Analytics III-52
Table 80: The UK Recent Past, Current and Future Analysis for
Collagen and HA-based Biomaterials by Product Group/Segment -
Collagen Based Biomaterials (Urinary Incontinence
Products, Corneal Shields, Facial Aesthetic Dermal Fillers
and Wound Dressings); and Hyaluronic Acid Based Biomaterials
(Viscosupplements, Viscoelastics and Facial Aesthetic Dermal
Fillers) Markets Independently Analyzed with Annual Sales
Figures in US$ Thousand for Years 2013 through 2020
(includes corresponding Graph/Chart) III-52

Table 81: The UK Historic Review for Collagen and HA-based
Biomaterials by Product Group/ Segment - Collagen Based
Biomaterials (Urinary Incontinence Products, Corneal
Shields, Facial Aesthetic Dermal Fillers and Wound
Dressings); and Hyaluronic Acid Based Biomaterials
(Viscosupplements, Viscoelastics and Facial Aesthetic Dermal
Fillers) Markets Independently Analyzed with Annual Sales
Figures in US$ Thousand for Years 2006 through 2012
(includes corresponding Graph/Chart) III-53

Table 82: The UK 15-Year Perspective for Collagen and
HA-based Biomaterials by Product Segment - Percentage
Breakdown of Dollar Sales for Collagen Based Biomaterials
(Urinary Incontinence Products, Corneal Shields, Facial
Aesthetic Dermal Fillers and Wound Dressings); and
Hyaluronic Acid Based Biomaterials (Viscosupplements,
Viscoelastics and Facial Aesthetic Dermal Fillers) Markets
for Years 2006, 2014 and 2020 (includes corresponding
Graph/Chart) III-54

4e. SPAIN III-55
Market Analysis III-55
Table 83: Spanish Recent Past, Current and Future Analysis for
Collagen and HA-based Biomaterials by Product Group/Segment -
Collagen Based Biomaterials (Urinary Incontinence
Products, Corneal Shields, Facial Aesthetic Dermal Fillers
and Wound Dressings); and Hyaluronic Acid Based Biomaterials
(Viscosupplements, Viscoelastics and Facial Aesthetic Dermal
Fillers) Markets Independently Analyzed with Annual Sales
Figures in US$ Thousand for Years 2013 through 2020
(includes corresponding Graph/Chart) III-56

Table 84: Spanish Historic Review for Collagen and HA-based
Biomaterials by Product Group/ Segment - Collagen Based
Biomaterials (Urinary Incontinence Products, Corneal
Shields, Facial Aesthetic Dermal Fillers and Wound
Dressings); and Hyaluronic Acid Based Biomaterials
(Viscosupplements, Viscoelastics and Facial Aesthetic Dermal
Fillers) Markets Independently Analyzed with Annual Sales
Figures in US$ Thousand for Years 2006 through 2012
(includes corresponding Graph/Chart) III-57

Table 85: Spanish 15-Year Perspective for Collagen and
HA-based Biomaterials by Product Segment - Percentage
Breakdown of Dollar Sales for Collagen Based Biomaterials
(Urinary Incontinence Products, Corneal Shields, Facial
Aesthetic Dermal Fillers and Wound Dressings); and
Hyaluronic Acid Based Biomaterials (Viscosupplements,
Viscoelastics and Facial Aesthetic Dermal Fillers) Markets
for Years 2006, 2014 and 2020 (includes corresponding
Graph/Chart) III-58

4f. RUSSIA III-59
Market Analysis III-59
Table 86: Russian Recent Past, Current and Future Analysis for
Collagen and HA-based Biomaterials by Product Group/Segment -
Collagen Based Biomaterials (Urinary Incontinence
Products, Corneal Shields, Facial Aesthetic Dermal Fillers
and Wound Dressings); and Hyaluronic Acid Based Biomaterials
(Viscosupplements, Viscoelastics and Facial Aesthetic Dermal
Fillers) Markets Independently Analyzed with Annual Sales
Figures in US$ Thousand for Years 2013 through 2020
(includes corresponding Graph/Chart) III-60

Table 87: Russian Historic Review for Collagen and HA-based
Biomaterials by Product Group/Segment - Collagen Based
Biomaterials (Urinary Incontinence Products, Corneal
Shields, Facial Aesthetic Dermal Fillers and Wound
Dressings); and Hyaluronic Acid Based Biomaterials
(Viscosupplements, Viscoelastics and Facial Aesthetic Dermal
Fillers) Markets Independently Analyzed with Annual Sales
Figures in US$ Thousand for Years 2006 through 2012
(includes corresponding Graph/Chart) III-61

Table 88: Russian 15-Year Perspective for Collagen and
HA-based Biomaterials by Product Segment - Percentage
Breakdown of Dollar Sales for Collagen Based Biomaterials
(Urinary Incontinence Products, Corneal Shields, Facial
Aesthetic Dermal Fillers and Wound Dressings); and
Hyaluronic Acid Based Biomaterials (Viscosupplements,
Viscoelastics and Facial Aesthetic Dermal Fillers) Markets
for Years 2006, 2014 and 2020 (includes corresponding
Graph/Chart) III-62

4g. REST OF EUROPE III-63
A.Market Analysis III-63
Strategic Corporate Development III-63
Galderma (Switzerland) - A Key Player III-63
B.Market Analytics III-64
Table 89: Rest of European Recent Past, Current and Future
Analysis for Collagen and HA-based Biomaterials by Product
Group/Segment - Collagen Based Biomaterials (Urinary
Incontinence Products, Corneal Shields, Facial Aesthetic
Dermal Fillers and Wound Dressings); and Hyaluronic Acid
Based Biomaterials (Viscosupplements, Viscoelastics and
Facial Aesthetic Dermal Fillers) Markets Independently
Analyzed with Annual Sales Figures in US$ Thousand for Years
2013 through 2020 (includes corresponding Graph/Chart) III-64

Table 90: Rest of European Historic Review for Collagen and
HA-based Biomaterials by Product Group/Segment - Collagen
Based Biomaterials (Urinary Incontinence Products, Corneal
Shields, Facial Aesthetic Dermal Fillers and Wound
Dressings); and Hyaluronic Acid Based Biomaterials
(Viscosupplements, Viscoelastics and Facial Aesthetic Dermal
Fillers) Markets Independently Analyzed with Annual Sales
Figures in US$ Thousand for Years 2006 through 2012
(includes corresponding Graph/Chart) III-65

Table 91: Rest of European 15-Year Perspective for Collagen
and HA-based Biomaterials by Product Segment - Percentage
Breakdown of Dollar Sales for Collagen Based Biomaterials
(Urinary Incontinence Products, Corneal Shields, Facial
Aesthetic Dermal Fillers and Wound Dressings); and
Hyaluronic Acid Based Biomaterials (Viscosupplements,
Viscoelastics and Facial Aesthetic Dermal Fillers) Markets
for Years 2006, 2014 and 2020 (includes corresponding
Graph/Chart) III-66

5. ASIA-PACIFIC III-67
A.Market Analysis III-67
Increasing Cataract Surgeries Drive Viscoelastics Market III-67
Facial Injectables Market Bodes Significant Potential III-67
India and China Offer Significant Growth Opportunities III-68
Table 92: China and India Lead Global Population (July
2013): Table Depicting China and India's Huge Population
Vis-a-vis Other Countries' Population (in Million) by Age
Group (includes corresponding Graph/Chart) III-68
China III-69
Orthopedic Biomaterials Market - A Review III-69
Singapore III-69
A Major Hub for Spine, Knee, and Hip Surgeries III-69
Strategic Corporate Development III-69
Lupin Limited (India) - A Key Player III-69
B.Market Analytics III-70
Table 93: Asia-Pacific Recent Past, Current and Future
Analysis for Collagen and HA- based Biomaterials by Product
Group/Segment - Collagen Based Biomaterials (Urinary
Incontinence Products, Corneal Shields, Facial Aesthetic
Dermal Fillers and Wound Dressings); and Hyaluronic Acid
Based Biomaterials (Viscosupplements, Viscoelastics and
Facial Aesthetic Dermal Fillers) Markets Independently
Analyzed with Annual Sales Figures in US$ Thousand for Years
2013 through 2020 (includes corresponding Graph/Chart) III-70

Table 94: Asia-Pacific Historic Review for Collagen and
HA-based Biomaterials by Product Group/ Segment - Collagen
Based Biomaterials (Urinary Incontinence Products, Corneal
Shields, Facial Aesthetic Dermal Fillers and Wound
Dressings); and Hyaluronic Acid Based Biomaterials
(Viscosupplements, Viscoelastics and Facial Aesthetic Dermal
Fillers) Markets Independently Analyzed with Annual Sales
Figures in US$ Thousand for Years 2006 through 2012
(includes corresponding Graph/Chart) III-71

Table 95: Asia-Pacific 15-Year Perspective for Collagen and
HA-based Biomaterials by Product Segment - Percentage
Breakdown of Dollar Sales for Collagen Based Biomaterials
(Urinary Incontinence Products, Corneal Shields, Facial
Aesthetic Dermal Fillers and Wound Dressings) and Hyaluronic
Acid Based (Viscosupplement, Viscoelastics and Facial
Aesthetic Dermal Fillers) Markets for Years 2006, 2014 and
2020 (includes corresponding Graph/Chart) III-72

6. REST OF WORLD III-73
Market Analysis III-73
Table 96: Rest of World Recent Past, Current and Future
Analysis for Collagen and HA- based Biomaterials by Product
Group/Segment - Collagen Based Biomaterials (Urinary
Incontinence Products, Corneal Shields, Facial Aesthetic
Dermal Fillers and Wound Dressings); and Hyaluronic Acid
Based Biomaterials (Viscosupplements, Viscoelastics and
Facial Aesthetic Dermal Fillers) Markets Independently
Analyzed with Annual Sales Figures in US$ Thousand for Years
2013 through 2020 (includes corresponding Graph/Chart) III-74

Table 97: Rest of World Historic Review for Collagen and
HA-based Biomaterials by Product Group/Segment - Collagen
Based Biomaterials (Urinary Incontinence Products, Corneal
Shields, Facial Aesthetic Dermal Fillers and Wound
Dressings); and Hyaluronic Acid Based Biomaterials
(Viscosupplements, Viscoelastics and Facial Aesthetic Dermal
Fillers) Markets Independently Analyzed with Annual Sales
Figures in US$ Thousand for Years 2006 through 2012
(includes corresponding Graph/Chart) III-75

Table 98: Rest of World 15-Year Perspective for Collagen and
HA-based Biomaterials by Product Segment - Percentage
Breakdown of Dollar Sales for Collagen Based Biomaterials
(Urinary Incontinence Products, Corneal Shields, Facial
Aesthetic Dermal Fillers and Wound Dressings) and Hyaluronic
Acid Based (Viscosupplement, Viscoelastics and Facial
Aesthetic Dermal Fillers) Markets for Years 2006, 2014 and
2020 (includes corresponding Graph/Chart) III-76


IV. COMPETITIVE LANDSCAPE

Total Companies Profiled: 55 (including Divisions/Subsidiaries - 60)

The United States (36)
Canada (1)
Japan (3)
Europe (18)
- France (1)
- Germany (4)
- The United Kingdom (5)
- Italy (1)
- Rest of Europe (7)
Asia-Pacific (Excluding Japan) (1)
Middle East (1)

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