Global Collagen and HA-Based Biomaterials Industry

• Publication date: February 2013
• Report size: 617 pages

This report analyzes the worldwide markets for Collagen and HA-Based Biomaterials in US$ Million by the following Classification based on Application Areas: Collagen Based Biomaterials (Urinary Incontinence, Corneal Shields, Facial Aesthetic Dermal Fillers, & Wound Dressings), and Hyaluronic Acid Based Biomaterials (Viscosupplements, Viscoelastics, & Facial Aesthetic Dermal Implants). The report provides separate comprehensive analytics for the U...

This report analyzes the worldwide markets for Collagen and HA-Based Biomaterials in US$ Million by the following Classification based on Application Areas: Collagen Based Biomaterials (Urinary Incontinence, Corneal Shields, Facial Aesthetic Dermal Fillers, & Wound Dressings), and Hyaluronic Acid Based Biomaterials (Viscosupplements, Viscoelastics, & Facial Aesthetic Dermal Implants). The report provides separate comprehensive analytics for the US, Canada, Japan, Europe, and Rest of World. Annual estimates and forecasts are provided for the period 2010 through 2018. Also, a six-year historic analysis is provided for these markets.

The report profiles 63 companies including many key and niche players such as ABBOTT, Alcon Laboratories, Inc., Allergan, Inc., Anika Therapeutics, Inc., Bausch & Lomb, Inc., Lifecore Biomedical, LLC, Q-Med AB, Sanofi SA, Genzyme, Seikagaku Corp., and Teijin Pharma Limited.

Market data and analytics are derived from primary and secondary research. Company profiles are primarily based upon search engine sources in the public domain.

Global Biomaterial Industry

I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS
Study Reliability and Reporting Limitations I-1
Disclaimers I-2
Data Interpretation & Reporting Level I-2
Quantitative Techniques & Analytics I-3
Product Definitions and Scope of Study I-3
Product Definitions I-4
Collagen-based Biomaterials I-4
Urinary Incontinence I-4
Corneal Shields I-4
Facial Aesthetic Dermal Fillers I-4
Wound Dressings I-4
Hyaluronic Acid (HA)-based Biomaterials I-4
Viscosupplements I-4
Viscoelastics I-4
Facial Aesthetic Dermal Fillers I-5


II. EXECUTIVE SUMMARY

1. GLOBAL MARKET OVERVIEW II-1
Outlook II-1
Review of Major Segments II-1
Collagen-Based Biomaterials II-1
Urinary Incontinence II-1
Corneal Shields II-2
Facial Aesthetic Dermal fillers II-2
Wound Dressings II-2
Hyaluronic Acid-based Biomaterials II-2
Viscosupplementation II-3
Viscoelastics market II-3
Facial Aesthetic Dermal Fillers II-3
Select HA-Based Products in the Global Market II-3
Regional Perspective II-4
Growth Drivers- At a Glance II-4
The Impact of Euro Zone Crisis on HA-Based Biomaterials Market II-4
Increasing Difficulties on the Reimbursement Front II-4
Increased Focus on Private Healthcare System II-5
Challenges II-5
Biomaterials Face Competition II-5
Competitive Scenario II-5
Leading Players in the Worldwide Collagen and HA-Based
Biomaterials Market II-6
Table 1: Global Viscosupplements market (2011): Percentage
Breakdown of Sales for Genzyme and Others (includes
corresponding Graph/Chart) II-7
World Collagen-based Wound Care Products (Global 2012)-
Select Products and Manufacturers II-7
Table 2: Global Advanced Wound Care Dressings Market (2012):
Percentage Share Breakdown of Value Sales for Smith & Nephew,
Convatec, Molnlycke, Coloplast, Systagenix, and Others
(includes corresponding Graph/Chart) II-7

2. MARKET TRENDS AND ISSUES II-8
Increasing Preference for Shorter and Convenient Treatment
Options II-8
Manufacturers Target Private Healthcare Market II-8
Population/Baby Boomers Play a Major Role II-8
Injectables Market on a High Growth Curve II-8
Skin Care Products Continue to Dominate Cosmeceuticals II-9
Hyaluronic-Acid Based Products Replace Other Facial Implant
Products II-9
Biomaterial Research Develops New Applications II-9
Issues and Threats II-10
Potential Shortage of Biomaterials II-10
Inadequate Reimbursements II-10

3. BIOMATERIALS - A BRIEF OVERVIEW II-11
Definition II-11
Types of Biomaterials for Medical Devices II-11
Polymers II-11
Composites II-11
Metals & Alloys II-11
Ceramics II-12
Biological Biomaterials II-12
Application of Various Forms of Biomaterials II-12
Collagen & Ha-Based Biomaterials II-12
Collagen Based Biomaterials II-13
What is Collagen? II-13
Collagen-Based Biomaterials II-13
Various Forms of Collagen and Applications II-14
Soft Tissue Fillers Offer Patients More Options II-14
Threatened by Alternatives II-14
Hyaluronic Acid (HA) II-14
Table 3: HA Distribution in the Body (includes corresponding
Graph/Chart) II-15
Properties of HA II-15

4. SEGMENT OVERVIEW II-16
Collagen Based Products II-16
Urinary Incontinence Implants II-16
Classification of Urinary Incontinence II-16
Stress Incontinence II-16
Urge Incontinence II-16
Overflow Incontinence II-16
Functional Incontinence II-17
Treatment of Urinary Incontinence II-17
Periurethral injections (Collagen Injections) II-17
Collagen Corneal Shields II-17
Research Proceedings II-18
Application of Collagen Shields II-18
Ocular Surface Lubrication II-18
Ocular Surface Protection II-18
Drug Delivery II-18
Wound Healing II-18
Facial Aesthetic Dermal fillers II-18
Functions of Collagen-based Facial Implants II-19
Aesthetic Dermal fillers - Playing a Major Role II-19
Normal Skin Changes Associated with Aging II-19
Collagen Injections as Facial implants II-19
Wound Dressings II-19
Leading Players in the Collagen-based Wound Dressings Market II-20
Global Wound Care Market Flaunts Steady Growth II-20
Other Applications of Collagen II-21
Collagen Gene Delivery Systems II-21
Collagen as Bone Graft Substitution II-21
Artificial Skin II-21
Hyaluronic Acid Based Biomaterials II-21
Viscosupplementation II-22
Hyaluronic Acid as Viscosupplement II-22
Viscosupplementation Treatment for Osteoarthritis II-22
Major Hyaluronic Acid Based Viscosupplements II-22
Viscoelastics II-23
Facial Aesthetic Dermal fillers II-23
Commercially Available HA Soft Tissue Fillers II-23
Review of Select HA based Aesthetic Dermal Implant Products II-23
Advantages of HA Based Products Over Collagen Products II-24
Vesicoureteral Reflux Implants II-24
Botox - A Competing Biomaterial II-24

5. PRODUCT INTRODUCTIONS/INNOVATIONS II-25
Innocoll Completes Phase 2 Studies of XaraColl® II-25
Abbott Receives European CE Mark for Healon® EndoCoat OVD II-25
Innocoll Obtains EU Approval of CollaGUARD Surgical Adhesion
Barrier II-25
LSP Bio Introduces SportVis™ and RenehaVis™ II-26
Lupin launches Hyalgan in India II-26
TiGenix Unveils ChondroMimetic™ II-26
TiGenix Develops Collagen Biomaterial for Regenerative Repair II-26
Lincoln Pharma Introduces Collagen Bio-Tech Products II-27
Healthpoint Launches SANTYL® Ointment for Canadian Market II-27
Teijin Pharma Introduces SYNVISC in Japan II-27
MiMedx Group Introduces New Paradis Vaso Shield™ Device II-28
Lifecore Introduces Corgel™ Biohydrogel II-28

6. RECENT INDUSTRY ACTIVITY II-29
Royal DSM Takes Over Kensey Nash II-29
Angel Biotechnology Holdings Acquires Specific Assets of
Collagen and Biomaterial Manufacturing Business II-29
Innocoll Signs License and Distribution Agreement with Inresa
Arzneimittel and Flynn Pharma II-30
ConvaTec Acquires Trio Healthcare International II-30
ConvaTec Holdings UK Acquires SureCalm Healthcare Holdings II-30
Mölnlycke Health Care US Takes Over Burn and Wound Care
Division of Brennen Medical II-31
Systagenix Takes Over O2 Insights II-31
Smith & Nephew Takes Over Kalypto Medical II-32
Novozymes Starts Supply of Hyaluronic Acid II-32
Galderma Acquires Q-Med II-32
Fidia Obtains Commercial Rights of Hyalgan from Sanofi US II-33
Anika Therapeutics and DePuy Mitek Ink licensing and supply
Agreement II-33
Merz Pharmaceutical Acquires BioForm Medical II-33
Landec Corporation Takes Over Lifecore Biomedical II-33
Anika Therapeutics Takes Over Fidia Advanced Biopolymers II-34
Anika Inks Agreement with Visco Technologies II-35
Kinetic Concepts Signs Agreement with Wright Medical Group II-35
Healthpoint Biotherapeutics Takes Over Regranex Gel II-35
Innocoll and Merus Labs Sign License and Distribution
Agreement for CollaGUARD II-36
SCA Acquires Majority Interest in San Saglik II-36
Sanofi Completes Genzyme Buyout II-36
Derma Sciences Inks Exclusive Distribution Agreement with
Medline Industries II-36
Quick- Med Technologies Signs Deal with Biosara Corp II-37
Medline Industries Enters into Wound Dressing Distribution
Agreement with Quick-Med Licensee II-37
BSX Signs Marketing Agreement with BHN II-37
Medtronic Acquires Osteotech II-38
Landec Completes Acquisition of Lifecore Biomedical II-38
Merz Completes Take Overof BioForm Medical II-38

7. CORPORATE ACTIVITY IN THE RECENT PAST - A PERSPECTIVE BUILDER II-39
Getinge AB Merges with Datascope Corp II-39
Human Biosciences GmbH Sets Up New Facility in Luckenwalde,
Germany II-39
TiGenix Takes Over Orthomimetics II-39
Integra LifeSciences Inks Licensing Deal with Organogenesis II-39
Abbott Takes Over Advanced Medical Optics II-40
Anika Signs Exclusive Distribution Agreement with Coapt
Systems II-40
Rousselot Takes Over PEPTAN II-41
Alynx Takes Over MiMedx II-41
Covidien Acquires Tissue Science Laboratories II-41
Warburg Pincus Takes Over Lifecore Biomedical II-41

8. FOCUS ON SELECT KEY PLAYERS II-42
ABBOTT (US) II-42
Alcon Laboratories, Inc. (US) II-42
Allergan, Inc. (US) II-43
Anika Therapeutics, Inc. (US) II-43
Bausch & Lomb, Inc. (US) II-44
Lifecore Biomedical, LLC (US) II-44
Q-Med AB (Sweden) II-45
Sanofi SA (France) II-45
Genzyme (US) II-46
Seikagaku Corp. (Japan) II-46
Teijin Pharma Limited (Japan) II-47

9. GLOBAL MARKET PERSPECTIVE II-48
Table 4: World Recent Past, Current & Future Analysis for
Collagen and HA-Based Biomaterials by Geographic Region - US,
Canada, Japan, Europe and Rest of World Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2010 through 2018 (includes corresponding Graph/Chart) II-48

Table 5: World Historic Review for Collagen and HA-Based
Biomaterials by Geographic Region - US, Canada, Japan, Europe,
and Rest of World Markets Independently Analyzed with Annual
Sales Figures in US$ Million for Years 2004 through 2009
(includes corresponding Graph/Chart) II-49

Table 6: World 15-Year Perspective for Collagen and HA-Based
Biomaterials by Geographic Region - Percentage Breakdown of
Dollar Sales for US, Canada, Japan, Europe and Rest of World
Markets for Years 2004, 2012 & 2018 (includes corresponding
Graph/Chart) II-50
Collagen and HA-Based Biomaterials Market by Product Group/
Segment II-51
Collagen-based Biomaterials Market by Region II-51
Table 7: World Recent Past, Current & Future Analysis for
Collagen Based Biomaterials by Geographic Region - US,
Canada, Japan, Europe, and Rest of World Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2010 through 2018 (includes corresponding
Graph/Chart) II-51

Table 8: World Historic Review for Collagen Based
Biomaterials by Geographic Region - US, Canada, Japan,
Europe, and Rest of World Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2004
through 2009 (includes corresponding Graph/Chart) II-52

Table 9: World 15-Year Perspective for Collagen Based
Biomaterials by Geographic Region - Percentage Breakdown of
Dollar Sales for US, Canada, Japan, Europe, and Rest of
World Markets for Years 2004, 2012 & 2018 (includes
corresponding Graph/Chart) II-53
Collagen Based Biomaterials Market by Product Segment II-54
Table 10: World Recent Past, Current & Future Analysis for
Collagen-based Biomaterials by Product Segment - Urinary
Incontinence Products, Corneal Shields, Facial Aesthetic
Dermal Fillers, and Wound Dressings Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2010 through 2018 (includes corresponding Graph/Chart) II-54

Table 11: World Historic Review for Collagen-based
Biomaterials by Product Segment - Urinary Incontinence
Products, Corneal Shields, Facial Aesthetic Dermal Fillers,
and Wound Dressings Markets Independently Analyzed with
Annual Sales Figures in US$ Million for Years 2004 through
2009 (includes corresponding Graph/Chart) II-55

Table 12: World 15-Year Perspective for Collagen-based
Biomaterials by Product Segment - Percentage Breakdown of
Dollar Sales for Urinary Incontinence Products, Corneal
Shields, Facial Aesthetic Dermal Fillers, and Wound
Dressings Markets for Years 2004, 2012 & 2018 (includes
corresponding Graph/Chart) II-56

Table 13: World Recent Past, Current & Future Analysis for
Collagen-based Urinary Incontinence Products by Geographic
Region - US, Canada, Japan, Europe and Rest of World
Markets Independently Analyzed with Annual Sales Figures in
US$ Million for Years 2010 through 2018 (includes
corresponding Graph/Chart) II-57

Table 14: World Historic Review for Collagen-based Urinary
Incontinence Products by Geographic Region - US, Canada,
Japan, Europe and Rest of World Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2004 through 2009 (includes corresponding Graph/Chart) II-58

Table 15: World 15-Year Perspective for Collagen-based
Urinary Incontinence Products by Geographic Region -
Percentage Breakdown of Dollar Sales for US, Canada, Japan,
Europe and Rest of World Markets for Years 2004, 2012 &
2018 (includes corresponding Graph/Chart) II-59

Table 16: World Recent Past, Current & Future Analysis for
Collagen-based Corneal Shields by Geographic Region - US,
Canada, Japan, Europe and Rest of World Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2010 through 2018 (includes corresponding
Graph/Chart) II-60

Table 17: World Historic Review for Collagen-based Corneal
Shields by Geographic Region - US, Canada, Japan, Europe
and Rest of World Markets Independently Analyzed with
Annual Sales Figures in US$ Million for Years 2004 through
2009 (includes corresponding Graph/Chart) II-61

Table 18: World 15-Year Perspective for Collagen-based
Corneal Shields by Geographic Region - Percentage Breakdown
of Dollar Sales for US, Canada, Japan, Europe and Rest of
World Markets for Years 2004, 2012 & 2018 (includes
corresponding Graph/Chart) II-62

Table 19: World Recent Past, Current & Future Analysis for
Collagen-based Facial Aesthetic Dermal Fillers by
Geographic Region - US, Canada, Japan, Europe, and Rest of
World Markets Independently Analyzed with Annual Sales
Figures in US$ Million for Years 2010 through 2018
(includes corresponding Graph/Chart) II-63

Table 20: World Historic Review for Collagen-based Facial
Aesthetic Dermal Fillers by Geographic Region - US, Canada,
Japan, Europe and Rest of World Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2004 through 2009 (includes corresponding Graph/Chart) II-64

Table 21: World 15-Year Perspective for Collagen-based
Facial Aesthetic Dermal Fillers by Geographic Region -
Percentage Breakdown of Dollar Sales for US, Canada, Japan,
Europe and Rest of World Markets for Years 2004, 2012 &
2018 (includes corresponding Graph/Chart) II-65

Table 22: World Recent Past, Current & Future Analysis for
Collagen-based Wound Dressings by Geographic Region - US,
Canada, Japan, Europe and Rest of World Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2010 through 2018 (includes corresponding
Graph/Chart) II-66

Table 23: World Historic Review for Collagen-based Wound
Dressings by Geographic Region - US, Canada, Japan,
Europe and Rest of World Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2004
through 2009 (includes corresponding Graph/Chart) II-67

Table 24: World 15-Year Perspective for Collagen-based
Wound Dressings by Geographic Region - Percentage Breakdown
of Dollar Sales for US, Canada, Japan, Europe and Rest of
World Markets for Years 2004, 2012 & 2018 (includes
corresponding Graph/Chart) II-68
Hyaluronic Acid Based Biomaterials Market by Geographic
Region II-69
Table 25: World Recent Past, Current & Future Analysis for
Hyaluronic Acid Based Biomaterials by Geographic Region -
US, Canada, Japan, Europe and Rest of World Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2010 through 2018 (includes corresponding
Graph/Chart) II-69

Table 26: World Historic Review for Hyaluronic Acid Based
Biomaterials by Geographic Region - US, Canada, Japan,
Europe and Rest of World Markets Independently Analyzed with
Annual Sales Figures in US$ Million for Years 2004 through
2009 (includes corresponding Graph/Chart) II-70

Table 27: World 15-Year Perspective for Hyaluronic Acid
Based Biomaterials by Geographic Region - Percentage
Breakdown of Dollar Sales for US, Canada, Japan, Europe and
Rest of World Markets for Years 2004, 2012 & 2018 (includes
corresponding Graph/Chart) II-71
Hyaluronic Acid Based Biomaterials Market by Product Segment II-72
Table 28: World Recent Past, Current & Future Analysis for
Hyaluronic Acid Based Biomaterials by Product Segment -
Viscosupplements, Viscoelastics and Facial Aesthetic Dermal
Fillers Independently Analyzed with Annual Sales Figures in
US$ Million for Years 2010 through 2018 (includes
corresponding Graph/Chart) II-72

Table 29: World Historic Review for Hyaluronic Acid Based
Biomaterials by Product Segment - Viscosupplements,
Viscoelastics and Facial Aesthetic Dermal Fillers
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2004 through 2009 (includes corresponding
Graph/Chart) II-73

Table 30: World 15-Year Perspective for Hyaluronic Acid
Based Biomaterials by Product Segment - Percentage
Breakdown of Dollar Sales for Viscosupplements,
Viscoelastics and Facial Aesthetic Dermal Fillers Markets
for Years 2004, 2012 & 2018 (includes corresponding
Graph/Chart) II-74

Table 31: World Recent Past, Current & Future Analysis for
Hyaluronic Acid Based Viscosupplements by Geographic Region
- US, Canada, Japan, Europe and Rest of World Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2010 through 2018 (includes corresponding
Graph/Chart) II-75

Table 32: World Historic Review for Hyaluronic Acid Based
Viscosupplements by Geographic Region - US, Canada, Japan,
Europe and Rest of World Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2004
through 2009 (includes corresponding Graph/Chart) II-76

Table 33: World 15-Year Perspective for Hyaluronic Acid
Based Viscosupplements by Geographic Region - Percentage
Breakdown of Dollar Sales for US, Canada, Japan, Europe and
Rest of World Markets for Years 2004, 2012 & 2018 (includes
corresponding Graph/Chart) II-77

Table 34: World Recent Past, Current & Future Analysis for
Hyaluronic Acid Based Viscoelastics by Geographic Region -
US, Canada, Japan, Europe and Rest of World Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2010 through 2018 (includes corresponding
Graph/Chart) II-78

Table 35: World Historic Review for Hyaluronic Acid Based
Viscoelastics by Geographic Region - US, Canada, Japan,
Europe and Rest of World Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2004
through 2009 (includes corresponding Graph/Chart) II-79

Table 36: World 15-Year Perspective for Hyaluronic Acid
Based Viscoelastics by Geographic Region - Percentage
Breakdown of Dollar Sales for US, Canada, Japan, Europe and
Rest of World Markets for Years 2004, 2012 & 2018 (includes
corresponding Graph/Chart) II-80

Table 37: World Recent Past, Current & Future Analysis for
Hyaluronic Acid Based Facial Aesthetic Dermal Fillersby
Geographic Region - US, Canada, Japan, Europe and Rest of
World Markets Independently Analyzed with Annual Sales
Figures in US$ Million for Years 2010 through 2018
(includes corresponding Graph/Chart) II-81

Table 38: World Historic Review for Hyaluronic Acid Based
Facial Aesthetic Dermal Fillersby Geographic Region - US,
Canada, Japan, Europe and Rest of World Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2004 through 2009 (includes corresponding
Graph/Chart) II-82

Table 39: World 15-Year Perspective for Hyaluronic Acid
Based Facial Aesthetic Dermal Fillersby Geographic Region -
Percentage Breakdown of Dollar Sales for US, Canada, Japan,
Europe and Rest of World Markets for Years 2004, 2012 &
2018 (includes corresponding Graph/Chart) II-83


III. MARKET

1. THE UNITED STATES III-1
A.Market Analysis III-1
Current and Future Analysis III-1
US - The Largest Biomaterials Market III-1
Market Trends III-1
Facial Aesthetics Market Grows in Popularity III-1
Growing Number of Cosmetic Procedures to Boost Sales III-2
Baby Boomers Trigger Growth III-2
Non-Surgical Cosmetic Procedures in the US III-2
US Facial Aesthetic Dermal Fillers Open Doors for New
Players III-2
Market Outlook by Segment III-3
Collagen Based Biomaterials III-3
Urinary Incontinence Products III-3
Leading Players III-3
Table 40: US Collagen-Based Urinary Incontinence
Implants Market by Leading Players (2011): Market Share
Breakdown for Allergan Inc. and Others (includes
corresponding Graph/Chart) III-3
Corneal Shields III-3
Facial Aesthetic Dermal Fillers Market - Highly
Competitive III-3
Wound Dressings Market III-4
HA Based Biomaterials III-4
Overview III-4
Viscosupplements III-4
Viscosupplements Spur Industry Growth III-4
Growth Drivers - A Glance III-5
Trends III-5
Hyaluronic Acid Knee Procedures on the Rise III-5
Table 41: US Viscosupplement Patient Share (2011):
Percentage breakdown of Osteoarthritis Patient Share for
Viscosupplement Treated and Untreated Patients (includes
corresponding Graph/Chart) III-5

Table 42: Number of Primary Knee arthoplasty Procedures
in the US (2011) (includes corresponding Graph/Chart) III-6
Patient Awareness Fuels Demand for Hyaluronic Acid
Viscosupplements III-6
Off-Label Use of Viscosupplement Products on the Rise III-6
Leading Players III-6
Table 43: US Hyaluronic Acid-based Viscosupplements
Market by Leading Players (2011): Market Share
Breakdown by Value Sales for Sanofi and Others
(includes corresponding Graph/Chart) III-7

Table 44: US Viscosupplements Market by Leading Brands
(2011): Percentage Breakdown of Value Sales for Synvisc
One, Synvisc, and Others (includes corresponding
Graph/Chart). III-7
Viscoelastics III-7
Table 45: US Hyaluronic Acid-based Viscoelastics Market
by Leading Players (2011): Market Share Breakdown by
Value Sales for Alcon, Abbott, Bausch & Lomb, and Others
(includes corresponding Graph/Chart) III-8
Dermal Fillers -The Fastest Growing segment III-8
Market Participants III-8
Strategic Corporate Developments III-8
Product Introductions III-14
Focus on Select Key Players III-15
B.Market Analytics III-20
Table 46: The US Recent Past, Current & Future Analysis for
Collagen and HA-based Biomaterials by Product Group/Segment
- Collagen Based Biomaterials (Urinary Incontinence
Products, Corneal Shields, Facial Aesthetic Dermal
Fillersand Wound Dressings); and Hyaluronic Acid Based
Biomaterials (Viscosupplements, Viscoelastics and Facial
Aesthetic Dermal Fillers) Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2010
through 2018 (includes corresponding Graph/Chart) III-20

Table 47: The US Historic Review for Collagen and HA-based
Biomaterials by Product Group/ Segment - Collagen Based
Biomaterials (Urinary Incontinence Products, Corneal
Shields, Facial Aesthetic Dermal Fillersand Wound
Dressings); and Hyaluronic Acid Based Biomaterials
(Viscosupplements, Viscoelastics and Facial Aesthetic Dermal
Fillers) Markets Independently Analyzed with Annual Sales
Figures in US$ Million for Years 2004 through 2009 (includes
corresponding Graph/Chart) III-21

Table 48: The US 15-Year Perspective for Collagen and
HA-based Biomaterials by Product Segment - Percentage
Breakdown of Dollar Sales for Collagen Based Biomaterials
(Urinary Incontinence Products, Corneal Shields, Facial
Aesthetic Dermal Fillersand Wound Dressings); and Hyaluronic
Acid Based Biomaterials (Viscosupplements, Viscoelastics and
Facial Aesthetic Dermal Fillers) Markets for Years 2004,
2012 & 2018 (includes corresponding Graph/Chart) III-22

2. CANADA III-23
A.Market Analysis III-23
Current and Future Analysis III-23
Strategic Corporate Developments III-23
B.Market Analytics III-24
Table 49: Canadian Recent Past, Current & Future Analysis
for Collagen and HA-based Biomaterials by Product
Group/Segment - Collagen Based Biomaterials (Urinary
Incontinence Products, Corneal Shields, Facial Aesthetic
Dermal Fillersand Wound Dressings); and Hyaluronic Acid
Based Biomaterials (Viscosupplements, Viscoelastics and
Facial Aesthetic Dermal Fillers) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2010 through 2018 (includes corresponding Graph/Chart) III-24

Table 50: Canadian Historic Review for Collagen and HA-based
Biomaterials by Product Group/ Segment - Collagen Based
Biomaterials (Urinary Incontinence Products, Corneal
Shields, Facial Aesthetic Dermal Fillersand Wound
Dressings); and Hyaluronic Acid Based Biomaterials
(Viscosupplements, Viscoelastics and Facial Aesthetic Dermal
Fillers) Markets Independently Analyzed with Annual Sales
Figures in US$ Million for Years 2004 through 2009 (includes
corresponding Graph/Chart) III-25

Table 51: Canadian 15-Year Perspective for Collagen and
HA-based Biomaterials by Product Segment - Percentage
Breakdown of Dollar Sales for Collagen Based Biomaterials
(Urinary Incontinence Products, Corneal Shields, Facial
Aesthetic Dermal Fillersand Wound Dressings); and Hyaluronic
Acid Based Biomaterials (Viscosupplements, Viscoelastics and
Facial Aesthetic Dermal Fillers) Markets for Years 2004,
2012 & 2018 (includes corresponding Graph/Chart) III-26

3. JAPAN III-27
A.Market Analysis III-27
Current and Future Analysis III-27
HA-Based Biomaterials III-27
HA-based Viscosupplement Treatment - Highly Popular in
Japan III-27
Competitors III-27
Collagen Based Biomaterials III-27
Product Introduction III-28
Select Key Players III-28
B.Market Analytics III-30
Table 52: Japanese Recent Past, Current & Future Analysis
for Collagen and HA-based Biomaterials by Product
Group/Segment - Collagen Based Biomaterials (Urinary
Incontinence Products, Corneal Shields, Facial Aesthetic
Dermal Fillersand Wound Dressings); and Hyaluronic Acid
Based Biomaterials (Viscosupplements, Viscoelastics and
Facial Aesthetic Dermal Fillers) Markets Independently
Analyzed with annual Sales Figures in US$ Million for Years
2010 through 2018 (includes corresponding Graph/Chart) III-30

Table 53: Japanese Historic Review for Collagen and HA-based
Biomaterials by Product Group/ Segment - Collagen Based
Biomaterials (Urinary Incontinence Products, Corneal
Shields, Facial Aesthetic Dermal Fillersand Wound
Dressings); and Hyaluronic Acid Based Biomaterials
(Viscosupplements, Viscoelastics and Facial Aesthetic Dermal
Fillers) Markets Independently Analyzed with annual Sales
Figures in US$ Million for Years 2004 through 2009 (includes
corresponding Graph/Chart) III-31

Table 54: Japanese 15-Year Perspective for Collagen and
HA-based Biomaterials by Product Segment - Percentage
Breakdown of Dollar Sales for Collagen Based Biomaterials
(Urinary Incontinence Products, Corneal Shields, Facial
Aesthetic Dermal Fillersand Wound Dressings); and Hyaluronic
Acid Based Biomaterials (Viscosupplements, Viscoelastics and
Facial Aesthetic Dermal Fillers) Markets for Years 2004,
2012 & 2018 (includes corresponding Graph/Chart) III-32

4. EUROPE III-33
A.Market Analysis III-33
Current and Future Analysis III-33
Collagen-based Biomaterials III-33
Hyaluronic Acid-based biomaterials III-33
Viscosupplement Market III-33
Competitive Scenario III-34
Table 55: European Viscosupplementation Products Market by
Leading Players (2011): Market Share Breakdown by Value
Sales for Fidia, Genzyme, Curasan, Seikagaku, and Others
(includes corresponding Graph/Chart) III-34
The Impact of Euro Zone Crisis on HA-based Biomaterials
Market III-34
Aesthetic Dermal Fillers Market III-35
B.Market Analytics III-36
Table 56: European Recent Past, Current & Future Analysis
for Collagen and HA-Based Biomaterials by Geographic Region
- France, Germany, Italy, UK & Rest of Europe Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2010 through 2018 (includes corresponding
Graph/Chart) III-36

Table 57: European Historic Review for Collagen and HA-Based
Biomaterials by Geographic Region - France, Germany, Italy,
UK & Rest of Europe Markets Independently Analyzed with
Annual Sales Figures in US$ Million for Years 2004 through
2009 (includes corresponding Graph/Chart) III-37

Table 58: European 15-Year Perspective for Collagen and
HA-Based Biomaterials by Geographic Region - Percentage
Breakdown of Dollar Sales for France, Germany, Italy, UK &
Rest of Europe Markets for Years 2004, 2012 & 2018 (includes
corresponding Graph/Chart) III-38

Table 59: European Recent Past, Current & Future Analysis
for Collagen and HA-based Biomaterials by Product
Group/Segment - Collagen Based Biomaterials (Urinary
Incontinence Products, Corneal Shields, Facial Aesthetic
Dermal Fillersand Wound Dressings); and Hyaluronic Acid
Based Biomaterials (Viscosupplements, Viscoelastics and
Facial Aesthetic Dermal Fillers) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2010 through 2018 (includes corresponding Graph/Chart) III-39

Table 60: European Historic Review for Collagen and HA-based
Biomaterials by Product Group/ Segment - Collagen Based
Biomaterials (Urinary Incontinence Products, Corneal
Shields, Facial Aesthetic Dermal Fillersand Wound
Dressings); and Hyaluronic Acid Based Biomaterials
(Viscosupplements, Viscoelastics and Facial Aesthetic Dermal
Fillers) Markets Independently Analyzed with Annual Sales
Figures in US$ Million for Years 2004 through 2009 (includes
corresponding Graph/Chart) III-40

Table 61: European 15-Year Perspective for Collagen and
HA-based Biomaterials by Product Segment - Percentage
Breakdown of Dollar Sales for Collagen Based Biomaterials
(Urinary Incontinence Products, Corneal Shields, Facial
Aesthetic Dermal Fillersand Wound Dressings); and Hyaluronic
Acid Based Biomaterials (Viscosupplements, Viscoelastics and
Facial Aesthetic Dermal Fillers) Markets for Years 2004,
2012 & 2018 (includes corresponding Graph/Chart) III-41

4a. FRANCE III-42
A.Market Analysis III-42
Current and Future Analysis III-42
Hyaluronic Acid Based Biomaterials III-42
Collagen Based Biomaterials III-42
Sanofi SA (France) - A Key Player III-42
B.Market Analytics III-43
Table 62: French Recent Past, Current & Future Analysis for
Collagen and HA-based Biomaterials by Product Group/Segment
- Collagen Based Biomaterials (Urinary Incontinence
Products, Corneal Shields, Facial Aesthetic Dermal
Fillersand Wound Dressings); and Hyaluronic Acid Based
Biomaterials (Viscosupplements, Viscoelastics and Facial
Aesthetic Dermal Fillers) Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2010
through 2018 (includes corresponding Graph/Chart) III-43

Table 63: French Historic Review for Collagen and HA-based
Biomaterials by Product Group/Segment - Collagen Based
Biomaterials (Urinary Incontinence Products, Corneal
Shields, Facial Aesthetic Dermal Fillersand Wound
Dressings); and Hyaluronic Acid Based Biomaterials
(Viscosupplements, Viscoelastics and Facial Aesthetic Dermal
Fillers) Markets Independently Analyzed with Annual Sales
Figures in US$ Million for Years 2004 through 2009 (includes
corresponding Graph/Chart) III-44

Table 64: French 15-Year Perspective for Collagen and
HA-based Biomaterials by Product Segment - Percentage
Breakdown of Dollar Sales for Collagen Based Biomaterials
(Urinary Incontinence Products, Corneal Shields, Facial
Aesthetic Dermal Fillersand Wound Dressings); and Hyaluronic
Acid Based Biomaterials (Viscosupplements, Viscoelastics and
Facial Aesthetic Dermal Fillers) Markets for Years 2004,
2012 & 2018 (includes corresponding Graph/Chart) III-45

4b. GERMANY III-46
A.Market Analysis III-46
Current and Future Analysis III-46
Hyaluronic Acid Based Biomaterials III-46
Collagen Based Biomaterials III-46
Strategic Corporate Developments III-46
B.Market Analytics III-48
Table 65: German Recent Past, Current & Future Analysis for
Collagen and HA-based Biomaterials by Product Group/Segment
- Collagen Based Biomaterials (Urinary Incontinence
Products, Corneal Shields, Facial Aesthetic Dermal
Fillersand Wound Dressings); and Hyaluronic Acid Based
Biomaterials (Viscosupplements, Viscoelastics and Facial
Aesthetic Dermal Fillers) Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2010
through 2018 (includes corresponding Graph/Chart) III-48

Table 66: German Historic Review for Collagen and HA-based
Biomaterials by Product Group/Segment - Collagen Based
Biomaterials (Urinary Incontinence Products, Corneal
Shields, Facial Aesthetic Dermal Fillersand Wound
Dressings); and Hyaluronic Acid Based Biomaterials
(Viscosupplements, Viscoelastics and Facial Aesthetic Dermal
Fillers) Markets Independently Analyzed with Annual Sales
Figures in US$ Million for Years 2004 through 2009 (includes
corresponding Graph/Chart) III-49

Table 67: German 15-Year Perspective for Collagen and
HA-based Biomaterials by Product Segment - Percentage
Breakdown of Dollar Sales for Collagen Based Biomaterials
(Urinary Incontinence Products, Corneal Shields, Facial
Aesthetic Dermal Fillersand Wound Dressings); and Hyaluronic
Acid Based Biomaterials (Viscosupplements, Viscoelastics and
Facial Aesthetic Dermal Fillers) Markets for Years 2004,
2012 & 2018 (includes corresponding Graph/Chart) III-50

4c. ITALY III-51
A.Market Analysis III-51
Current and Future Analysis III-51
Hyaluronic Acid Based Biomaterials III-51
Collagen Based Biomaterials III-51
Strategic Corporate Developments III-51
B.Market Analytics III-53
Table 68: Italian Recent Past, Current & Future Analysis for
Collagen and HA-based Biomaterials by Product Group/Segment
- Collagen Based Biomaterials (Urinary Incontinence
Products, Corneal Shields, Facial Aesthetic Dermal
Fillersand Wound Dressings); and Hyaluronic Acid Based
Biomaterials (Viscosupplements, Viscoelastics and Facial
Aesthetic Dermal Fillers) Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2010
through 2018 (includes corresponding Graph/Chart) III-53

Table 69: Italian Historic Review for Collagen and HA-based
Biomaterials by Product Group/Segment - Collagen Based
Biomaterials (Urinary Incontinence Products, Corneal
Shields, Facial Aesthetic Dermal Fillersand Wound
Dressings); and Hyaluronic Acid Based Biomaterials
(Viscosupplements, Viscoelastics and Facial Aesthetic Dermal
Fillers) Markets Independently Analyzed with Annual Sales
Figures in US$ Million for Years 2004 through 2009 (includes
corresponding Graph/Chart) III-54

Table 70: Italian 15-Year Perspective for Collagen and
HA-based Biomaterials by Product Segment - Percentage
Breakdown of Dollar Sales for Collagen Based Biomaterials
(Urinary Incontinence Products, Corneal Shields, Facial
Aesthetic Dermal Fillersand Wound Dressings); and Hyaluronic
Acid Based Biomaterials (Viscosupplements, Viscoelastics and
Facial Aesthetic Dermal Fillers) Markets for Years 2004,
2012 & 2018 (includes corresponding Graph/Chart) III-55

4d. THE UNITED KINGDOM III-56
A.Market Analysis III-56
Current and Future Analysis III-56
Hyaluronic Acid Based Biomaterials III-56
Collagen Based Biomaterials III-56
Strategic Corporate Developments III-56
B.Market Analytics III-59
Table 71: The UK Recent Past, Current & Future Analysis for
Collagen and HA-based Biomaterials by Product Group/Segment
- Collagen Based Biomaterials (Urinary Incontinence
Products, Corneal Shields, Facial Aesthetic Dermal
Fillersand Wound Dressings); and Hyaluronic Acid Based
Biomaterials (Viscosupplements, Viscoelastics and Facial
Aesthetic Dermal Fillers) Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2010
through 2018 (includes corresponding Graph/Chart) III-59

Table 72: The UK Historic Review for Collagen and HA-based
Biomaterials by Product Group/ Segment - Collagen Based
Biomaterials (Urinary Incontinence Products, Corneal
Shields, Facial Aesthetic Dermal Fillersand Wound
Dressings); and Hyaluronic Acid Based Biomaterials
(Viscosupplements, Viscoelastics and Facial Aesthetic Dermal
Fillers) Markets Independently Analyzed with Annual Sales
Figures in US$ Million for Years 2004 through 2009 (includes
corresponding Graph/Chart) III-60

Table 73: The UK 15-Year Perspective for Collagen and
HA-based Biomaterials by Product Segment - Percentage
Breakdown of Dollar Sales for Collagen Based Biomaterials
(Urinary Incontinence Products, Corneal Shields, Facial
Aesthetic Dermal Fillersand Wound Dressings); and Hyaluronic
Acid Based Biomaterials (Viscosupplements, Viscoelastics and
Facial Aesthetic Dermal Fillers) Markets for Years 2004,
2012 & 2018 (includes corresponding Graph/Chart) III-61

4e. REST OF EUROPE III-62
A.Market Analysis III-62
Current and Future Analysis III-62
Hyaluronic Acid Based Biomaterials III-62
Collagen Based Biomaterials III-62
Strategic Corporate Developments III-62
Product Introductions III-63
Q-Med AB (Sweden)- a Key Player III-63
B.Market Analytics III-65
Table 74: Rest of European Recent Past, Current & Future
Analysis for Collagen and HA-based Biomaterials by Product
Group/ Segment - Collagen Based Biomaterials (Urinary
Incontinence Products, Corneal Shields, Facial Aesthetic
Dermal Fillersand Wound Dressings); and Hyaluronic Acid
Based Biomaterials (Viscosupplements, Viscoelastics and
Facial Aesthetic Dermal Fillers) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2010 through 2018 (includes corresponding Graph/Chart) III-65

Table 75: Rest of European Historic Review for Collagen and
HA-based Biomaterials by Product Group/Segment - Collagen
Based Biomaterials (Urinary Incontinence Products, Corneal
Shields, Facial Aesthetic Dermal Fillersand Wound
Dressings); and Hyaluronic Acid Based Biomaterials
(Viscosupplements, Viscoelastics and Facial Aesthetic Dermal
Fillers) Markets Independently Analyzed with Annual Sales
Figures in US$ Million for Years 2004 through 2009 (includes
corresponding Graph/Chart) III-66

Table 76: Rest of European 15-Year Perspective for Collagen
and HA-based Biomaterials by Product Segment - Percentage
Breakdown of Dollar Sales for Collagen Based Biomaterials
(Urinary Incontinence Products, Corneal Shields, Facial
Aesthetic Dermal Fillersand Wound Dressings); and Hyaluronic
Acid Based Biomaterials (Viscosupplements, Viscoelastics and
Facial Aesthetic Dermal Fillers) Markets for Years 2004,
2012 & 2018 (includes corresponding Graph/Chart) III-67

5. REST OF WORLD III-68
A.Market Analysis III-68
Current and Future Analysis III-68
Hyaluronic Acid Based Biomaterials III-68
Collagen Based Biomaterials III-68
Asia Pacific Facial Injectables Market Bodes Significant
Potential III-68
Strategic Corporate Developments III-69
Lupin Limited (India) - A Key Player III-70
B.Market Analytics III-71
Table 77: Rest of World Recent Past, Current & Future
Analysis for Collagen and HA- based Biomaterials by Product
Group/Segment - Collagen Based Biomaterials (Urinary
Incontinence Products, Corneal Shields, Facial Aesthetic
Dermal Fillersand Wound Dressings); and Hyaluronic Acid
Based Biomaterials (Viscosupplements, Viscoelastics and
Facial Aesthetic Dermal Fillers) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2010 through 2018 (includes corresponding Graph/Chart) III-71

Table 78: Rest of World Recent Historic Review for Collagen
and HA-based Biomaterials by Product Group/Segment -
Collagen Based Biomaterials (Urinary Incontinence Products,
Corneal Shields, Facial Aesthetic Dermal Fillersand Wound
Dressings); and Hyaluronic Acid Based Biomaterials
(Viscosupplements, Viscoelastics and Facial Aesthetic Dermal
Fillers) Markets Independently Analyzed with Annual Sales
Figures in US$ Million for Years 2004 through 2009
(includes corresponding Graph/Chart) III-72

Table 79: Rest of World 15-Year Perspective for Collagen and
HA-based Biomaterials by Product Segment - Percentage
Breakdown of Dollar Sales for Collagen Based Biomaterials
(Urinary Incontinence Products, Corneal Shields, Facial
Aesthetic Dermal Fillers and Wound Dressings) and Hyaluronic
Acid Based (Viscosupplement, Viscoelastics and Facial
Aesthetic Dermal Fillers) Markets for Years 2004, 2012 &
2018 (includes corresponding Graph/Chart) III-73


IV. COMPETITIVE LANDSCAPE

Total Companies Profiled: 63 (including Divisions/Subsidiaries - 69)

The United States (44)
Canada (2)
Japan (3)
Europe (18)
- France (1)
- Germany (3)
- The United Kingdom (5)
- Italy (1)
- Rest of Europe (8)
Asia-Pacific (Excluding Japan) (1)
Middle-East (1)