INTRODUCTION

STUDY OBJECTIVES

BCC’s goal in conducting this study is to provide an overview of the current and future characteristics of the global market for media, sera and the reagents used in biotechnology. The key objective is to present a comprehensive analysis of the current market and its future direction in the media, sera and biotechnology reagents markets as an important tool for the cell culture industry.

This report explores present and future strategies within the media and sera market, including reagents used in biotechnology. The improvisation of the market, the setbacks and the needs of the market are discussed in this report. The types of cell cultures and the products from cell culture technology are also presented in this report. The advantages and disadvantages for the use of various types of media are also covered in this report.

A detailed analysis of the cell culture industry structure has been conducted. This includes the biotechnology reagents, media and the sera used. Revenues are broken down by global region. Sales figures are estimated for the five-year period from 2011 through 2016.

Applications for the cell culture industry—media, sera and reagents used in biotechnology—are also discussed in the report, with an emphasis on the usage in the research, production and contract segments. The report also covers significant patents in each segment.

REASONS FOR DOING THIS STUDY

Demand for cell culture products, namely media, sera and reagents, is increasing, with the increasing demand for biopharmaceuticals. Cell culture, a crucial component of the life sciences industry, has witnessed major development during the past three decades. R&D spending, along with increasing competition, patent expiries, new technologies and an international marketplace are moving the cell culture process in a new direction. As cell culture technologies evolved, a number of disciplines such as cell biology, genetic engineering, protein chemistry, genomics and chemical engineering have been successfully incorporated into the cell culture field.

Acquisition strategies and collaborations by companies are also covered in this report. This study also discusses the strength and weaknesses of the different types of media used in light of the new technologies, growing competition and changing customer needs.

INTENDED AUDIENCE

This study contributes to the areas of market growth in the cell culture industry from the point of view of manufacturers and users. Biotechnological companies, physicians, the pharmaceutical and biopharmaceutical industries, hospitals and research institutes will find this study to be of interest.

SCOPE OF THE STUDY

The scope of this study encompasses the biotechnology, pharmaceutical and medical markets. BCC analyzes each market and its applications by its need for development of new medications through cell culture techniques, the regulatory environment, technology involved, market projections and market share. Technological issues include the latest trends and developments.

METHODOLOGY

BCC conducted a comprehensive literature search, which included technical newsletters and journals, and many other sources. Data was collected through interviews and correspondence with various analytical, chemical, pharmaceutical and biotechnical experts. Projections were based on estimates such as the current number of end users, potential end users, mergers and acquisitions, and market trends.

INFORMATION SOURCES

Many companies within the industry were surveyed to obtain data for this study. Included were manufacturers and end users of biopharmaceuticals, and pharmaceutical companies through their production, research and contract manufacturing/research lines. Data were gathered from various industry sources. BCC spoke with officials and physicians within the industry, consulted newsletters, company literature, product literature and a host of technical articles, journals, indexes and abstracts. Exhaustive investigations of databases by key terminology were completed. In addition, data were compiled from current financial, trade and government sources.

ABOUT THE AUTHOR

The study has been carried out by a team of professionals in the biotechnology industry. The project manager for this project is Shalini S. Dewan, who holds a Master’s degree in Pharmaceutical Chemistry and has more than 14 years of industry experience. Among the research topics she has covered are studies on compounds of potential pharmaceutical interest from ibuprofen and 2-naphthyl acetic acid. Shalini was awarded a Gold Medal by the Prime Minister of India for her work and has worked with top companies in India and in the U.S. Some of her other reports with BCC are Reagents for Chromatography; Spectroscopy, an Enduring Market; Advanced Drug Delivery Systems: Technologies and Global Markets; Orthopedic Drugs, Implants and Devices; Medical Imaging Reagents and Analysis Equipment; Pharmaceutical Regulatory Industry; The Dynamic Media, Sera and Reagent Market in Biotechnology; Contract Pharmaceutical Manufacturing, Research and Packaging: Global Markets; Chiral Technology: Global Markets; Autacoids and Related Drugs: Technologies and Global Markets; Contraceptives: Technologies and Global Markets; Liver Disease Treatments: The Global Market; Hormone Replacement Therapies and Other Hormone Therapies: Global Markets; Cardiovascular Medicine: Diagnostics, Drugs and Devices; and Cancer Therapies: Technologies and Global Markets.

The lead consultant for this project was Dr. Kapil A. Setia, who holds a doctoral degree in the life sciences. She has a number of research publications to her credit.

Table Of Contents

TABLE OF CONTENTS

CHAPTER ONE: INTRODUCTION 1
STUDY OBJECTIVES 1
REASONS FOR DOING THIS STUDY 1
INTENDED AUDIENCE 2
SCOPE OF THE STUDY 2
METHODOLOGY 2
INFORMATION SOURCES 2
ABOUT THE AUTHOR 3
RELATED BCC RESEARCH REPORTS 3
BCC ONLINE SERVICES 3
DISCLAIMER 4
CHAPTER TWO: EXECUTIVE SUMMARY 5
EXECUTIVE SUMMARY 5
SUMMARY TABLE GLOBAL REVENUES FROM MEDIA, SERA AND
REAGENTS USED IN THE BIOTECHNOLOGY MARKET,
THROUGH 2016 ($ MILLIONS) 6
SUMMARY FIGURE GLOBAL REVENUES FROM MEDIA, SERA AND
REAGENTS USED IN THE BIOTECHNOLOGY MARKET, 2009-2016
($ MILLIONS) 6
EXECUTIVE SUMMARY (CONTINUED) 7
CHAPTER THREE: OVERVIEW 8
DEFINITIONS 8
HISTORY 8
TABLE 1 (CONTINUED) 10
TYPES OF CELL CULTURES 10
PRIMARY CULTURES 10
TABLE 2 ADVANTAGES AND DISADVANTAGES OF PRIMARY CELL
CULTURE 11
SECONDARY CELL CULTURE 11
CONTINUOUS CELL CULTURE 11
TABLE 3 ADVANTAGES AND DISADVANTAGES OF CONTINUOUS
CELL CULTURE 12
MORPHOLOGY OF CELLS IN CULTURE 12
FIBROBLASTIC CELLS 12
EPITHELIAL-LIKE CELLS 12
LYMPHOBLAST-LIKE CELLS 12
BASIC SYSTEMS FOR CELL CULTURE 12
TABLE 4 ADHERENT CULTURE VS SUSPENSION CULTURE 13
CELL LINE, CELL STRAIN AND TRANSFORMED CELL LINES 13
CHARACTERISTICS OF IMMORTALIZED CELL LINES 14
FACTORS AFFECTING CELL CULTURE 14
APPLICATIONS OF CELL CULTURE 15
MODEL SYSTEM 15
CANCER RESEARCH 15
VIROLOGY 15
TABLE 5 CULTURE MEDIA USED FOR THE PRODUCTION OF
VACCINES 16
TABLE 5 (CONTINUED) 17
GENETICALLY ENGINEERED PROTEINS 17
TABLE 6 POTENTIAL SOURCES OF CELL CULTURE ADDITIVES 18
Recombinant Thrombolytic Agents 19
TABLE 7 RECOMBINANT THROMBOLYTIC AGENTS 19
Recombinant Coagulation Factor 19
TABLE 8 RECOMBINANT COAGULATION FACTOR 20
Cytokines 20
Hematopoietic Growth Factors 21
Human Growth Hormones 22
Monoclonal Antibodies 22
TISSUE AND ORGAN REPLACEMENT 22
GENETIC COUNSELING 23
GENE THERAPY 23
PROBLEMS DURING CELL CULTURE 23
TOXICITY 23
MICROBIAL CONTAMINATION 23
Cross-Contamination 24
BASIC REQUIREMENTS OF CELL CULTURE 24
CELL CULTURE MEDIA 24
Basic Constituents of Media 24
Inorganic Salts 24
TABLE 9 THE ROLES OF DIFFERENT INORGANIC NUTRIENTS 25
Buffering Systems 25
Energy Source 26
Amino Acids 26
Vitamins 26
Proteins and Peptides 27
Fatty Acids and Lipids 27
Trace Elements 27
Antibiotics 28
TABLE 10 COMMONLY USED ANTIBIOTICS IN CELL CULTURES 28
Serum 29
Types of Cell Culture Media 29
Serum-Containing Media 29
TABLE 11 ADVANTAGES AND DISADVANTAGES OF SERUMCONTAINING
MEDIA 30
Serum-free Media 30
TABLE 12 ADVANTAGES AND DISADVANTAGES OF SERUM-FREE
MEDIA 31
Chemically Defined Media 31
Amino Acids 31
Carbohydrates 32
Inorganic Salts 32
Vitamins 32
Protein-Free Media 32
Selection of Cell Culture Media 33
Serum-Free Media: Reasons for Preference 33
Supplements for Serum-Free Media 33
Hormones 34
Transferrin 34
Lipids 34
Hydrolysates 35
SERUM 35
Role of Serum in Cell Culture 35
Serum Components 36
Growth Factors 36
Albumin 36
Protease Inhibitors 36
TABLE 13 NORMAL RANGE OF CONCENTRATION OF SERUM
CONSTITUENTS 36
TABLE 13 (CONTINUED) 37
Sources of Serum 37
Fetal Bovine Serum 37
Calf Serum 37
Calf Serum, Donor (Bovine) 37
Calf Serum, Newborn (Bovine) 37
Other Animal Sera 38
Chicken Serum 38
Dog Serum 38
Donor Donkey Serum 38
Donor Goat Serum 38
Donor Rat Serum 38
Rat Serum 38
Feline Serum 38
Guinea Pig Serum 39
Monkey Serum 39
Mouse Serum 39
Porcine Serum 39
Rabbit Serum 39
Sheep Serum 39
Horse Serum 39
Potential Problems with Serum 40
Serum Selection 40
CELL CULTURE REAGENTS 41
Amino Acids and Vitamins 41
Antibiotics and Antimycotics 41
Buffers 41
Cell Dissociation Agents 42
Growth Supplements 42
REGULATORY ASPECTS 42
APPROVALS OF BIOLOGICAL LICENSE APPLICATIONS 43
TABLE 14 APPROVALS OF BIOLOGICAL LICENSE APPLICATIONS,
2010 TO AUG 2011 43
TABLE 14 (CONTINUED) 44
ADMINISTRATIVE ACTIONS: BIOLOGICS 44
TABLE 15 ADMINISTRATIVE ACTIONS: BIOLOGICS, 2007 TO AUG
2011 44
TABLE 15 (CONTINUED) 45
TABLE 16 PRODUCT RECALLS, 2007 TO AUG 2011 46
TABLE 16 (CONTINUED) 47
TABLE 16 (CONTINUED) 48
LEADING MANUFACTURERS OF MEDIA 48
TABLE 17 LEADING MANUFACTURERS OF MEDIA 48
TABLE 17 (CONTINUED) 49
TABLE 17 (CONTINUED) 50
TABLE 17 (CONTINUED) 51
TABLE 17 (CONTINUED) 52
TABLE 17 (CONTINUED) 53
TABLE 17 (CONTINUED) 54
TABLE 18 LEADING MANUFACTURERS OF SERA 54
TABLE 18 (CONTINUED) 55
TABLE 18 (CONTINUED) 56
TABLE 19 LEADING MANUFACTURERS OF BIOLOGIC RESPONSE
MODIFIERS 57
TABLE 19 (CONTINUED) 58
TABLE 19 (CONTINUED) 59
TABLE 19 (CONTINUED) 60
TABLE 20 LEADING MANUFACTURERS OF CELL DISSOCIATION
REAGENTS 60
TABLE 20 (CONTINUED) 61
TABLE 21 LEADING MANUFACTURERS OF ANTIBIOTICS AND
ANTIMYCOTICS USED IN CELL CULTURE 62
TABLE 21 (CONTINUED) 63
TABLE 22 LEADING MANUFACTURERS OF OTHER REAGENTS 63
TABLE 22 (CONTINUED) 64
TABLE 22 (CONTINUED) 65
NEW DEVELOPMENTS 66
TABLE 23 NEW DEVELOPMENTS IN THE CELL CULTURE
INDUSTRY SINCE 2008 67
TABLE 23 (CONTINUED) 68
NEW DEVELOPMENTS IN APPLICATIONS 68
NEW DEVELOPMENTS IN APPLICATIONS (CONTINUED) 69
TABLE 24 NEW DEVELOPMENTS IN APPLICATION OF CELL
CULTURE 70
TABLE 24 (CONTINUED) 71
CHAPTER FOUR: GLOBAL MARKETS 72
GLOBAL MARKETS 72
GLOBAL MARKETS (CONTINUED) 73
TABLE 25 GLOBAL MARKET FOR CELL CULTURE PRODUCTS,
THROUGH 2016 ($ MILLIONS) 74
FIGURE 1 GLOBAL MARKET FOR CELL CULTURE PRODUCTS,
2009-2016 ($ MILLIONS) 74
MEDIA 75
MARKET REVENUE 76
TABLE 26 GLOBAL MARKET FOR MEDIA USED IN
BIOTECHNOLOGY BY REGION, THROUGH 2016 ($ MILLIONS) 76
FIGURE 2 GLOBAL MARKET FOR MEDIA USED IN
BIOTECHNOLOGY BY REGION, 2009-2016 ($ MILLIONS) 76
MARKET SHARES 77
TABLE 27 GLOBAL BIOTECHNOLOGY MEDIA MARKET SHARES BY
REGION, 2010 (%) 77
FIGURE 3 GLOBAL BIOTECHNOLOGY MEDIA MARKET SHARES BY
REGION, 2010 (%) 77
SERUM-FREE MEDIA AND SERUM-REQUIRING MEDIA 78
Serum-Free Media Market Revenue 78
TABLE 28 GLOBAL MARKET FOR SERUM-FREE MEDIA BY REGION,
THROUGH 2016 ($ MILLIONS) 79
FIGURE 4 GLOBAL MARKET FOR SERUM-FREE MEDIA BY REGION,
2009-2016 ($ MILLIONS) 79
Serum-Requiring Media Market Revenue 80
TABLE 29 GLOBAL MARKET FOR SERUM-REQUIRING MEDIA BY
REGION, THROUGH 2016 ($ MILLIONS) 80
FIGURE 5 GLOBAL MARKET FOR SERUM-REQUIRING MEDIA BY
REGION, 2009-2016 ($ MILLIONS) 81
POWDERED MEDIA AND LIQUID MEDIA 81
Powdered Media Market Revenue 82
TABLE 30 GLOBAL MARKET FOR POWDERED MEDIA, THROUGH
2016 ($ MILLIONS) 82
FIGURE 6 GLOBAL MARKET FOR POWDERED MEDIA, 2009-2016 ($
MILLIONS) 82
Liquid Media Market Revenue 83
TABLE 31 GLOBAL MARKET FOR LIQUID MEDIA BY REGION,
THROUGH 2016 ($ MILLIONS) 83
FIGURE 7 GLOBAL MARKET FOR LIQUID MEDIA BY REGION, 2009-
2016 ($ MILLIONS) 83
CLASSICAL AND SPECIALTY MEDIA 84
Classical Media Market Revenue 84
TABLE 32 GLOBAL MARKET FOR CLASSICAL MEDIA BY REGION,
THROUGH 2016 ($ MILLIONS) 85
FIGURE 8 GLOBAL MARKET FOR CLASSICAL MEDIA BY REGION,
2009-2016 ($ MILLIONS) 85
Specialty Media Market Revenue 86
TABLE 33 GLOBAL MARKET FOR SPECIALTY MEDIA BY REGION,
THROUGH 2016 ($ MILLIONS) 86
FIGURE 9 GLOBAL MARKET FOR SPECIALTY MEDIA BY REGION,
2009-2016 ($ MILLIONS) 86
SERA 87
MARKET REVENUE 88
TABLE 34 GLOBAL MARKET FOR SERA BY REGION, THROUGH
2016 ($ MILLIONS) 88
FIGURE 10 GLOBAL MARKET FOR SERA BY REGION, 2009-2016 ($
MILLIONS) 88
MARKET SHARES 89
TABLE 35 GLOBAL SERA MARKET SHARES BY REGION, 2010 (%) 89
FIGURE 11 GLOBAL SERA MARKET SHARES BY REGION, 2010 (%) 89
BOVINE SERA OR FETAL BOVINE SERA 90
TABLE 36 GLOBAL MARKET FOR BOVINE SERA BY REGION,
THROUGH 2016 ($ MILLIONS) 90
FIGURE 12 GLOBAL MARKET FOR BOVINE SERA BY REGION, 2009-
2016 ($ MILLIONS) 91
OTHER SERA 91
TABLE 37 GLOBAL MARKET FOR OTHER SERA BY REGION,
THROUGH 2016 ($ MILLIONS) 92
FIGURE 13 GLOBAL MARKET FOR OTHER SERA BY REGION, 2009-
2016 ($ MILLIONS) 92
REAGENTS 93
MARKET OVERVIEW 94
MARKET REVENUE 95
TABLE 38 GLOBAL MARKET FOR CELL CULTURE REAGENTS BY
REGION, THROUGH 2016 ($ MILLIONS) 95
FIGURE 14 GLOBAL MARKET FOR CELL CULTURE REAGENTS BY
REGION, 2009-2016 ($ MILLIONS) 96
MARKET SHARES 96
TABLE 39 GLOBAL CELL CULTURE REAGENT MARKET SHARES
BY REGION, 2010 (%) 96
FIGURE 15 GLOBAL CELL CULTURE REAGENT MARKET SHARES
BY REGION, 2010 (%) 97
BIOLOGICAL RESPONSE MODIFIERS 97
TABLE 40 GLOBAL MARKET FOR BIOLOGICAL RESPONSE
MODIFIERS BY REGION, THROUGH 2016 ($ MILLIONS) 97
FIGURE 16 GLOBAL MARKET FOR BIOLOGICAL RESPONSE
MODIFIERS BY REGION, 2009-2016 ($ MILLIONS) 98
Growth Factors 98
TABLE 41 GLOBAL MARKET FOR GROWTH FACTORS BY REGION,
THROUGH 2016 ($ MILLIONS) 99
FIGURE 17 GLOBAL MARKET FOR GROWTH FACTORS BY REGION,
2009- 2016 ($ MILLIONS) 99
Cytokines 99
TABLE 42 GLOBAL MARKET FOR CYTOKINES BY REGION,
THROUGH 2016 ($ MILLIONS) 100
FIGURE 18 GLOBAL MARKET FOR CYTOKINES BY REGION, 2009-
2016 ($ MILLIONS) 100
Other Biological Response Modifiers 100
TABLE 43 GLOBAL MARKET FOR OTHER BIOLOGICAL RESPONSE
MODIFIERS BY REGION, THROUGH 2016 ($ MILLIONS) 101
FIGURE 19 GLOBAL MARKET FOR OTHER BIOLOGICAL RESPONSE
MODIFIERS BY REGION, 2009-2016 ($ MILLIONS) 101
CELL DISSOCIATION REAGENTS 102
TABLE 44 GLOBAL MARKET FOR CELL DISSOCIATION REAGENTS
BY REGION, THROUGH 2016 ($ MILLIONS) 102
FIGURE 20 GLOBAL MARKET FOR CELL DISSOCIATION
REAGENTS BY REGION, 2009-2016 ($ MILLIONS) 102
OTHERS 103
TABLE 45 GLOBAL MARKET FOR OTHERS BY REGION, THROUGH
2016 ($ MILLIONS) 103
FIGURE 21 GLOBAL MARKET FOR OTHERS BY REGION, 2009-2016
($ MILLIONS) 104
CHAPTER FIVE: U S MARKET 105
TABLE 46 U S MARKET FOR CELL CULTURE PRODUCTS,
THROUGH 2016 ($ MILLIONS) 105
FIGURE 22 U S MARKET FOR CELL CULTURE PRODUCTS, 2009-
2016 ($ MILLIONS) 106
MEDIA 106
MARKET OVERVIEW 106
Market Overview (Continued) 107
MARKET REVENUE 108
TABLE 47 U S MARKET FOR CELL CULTURE MEDIA, THROUGH
2016 ($ MILLIONS) 108
FIGURE 23 U S MARKET FOR CELL CULTURE MEDIA, 2009-2016 ($
MILLIONS) 109
SERUM-REQUIRING AND SERUM-FREE MEDIA 109
Market Revenue 110
TABLE 48 U S MARKET FOR SERUM-REQUIRING AND SERUMFREE
MEDIA, THROUGH 2016 ($ MILLIONS) 111
FIGURE 24 U S MARKET FOR SERUM-REQUIRING AND SERUMFREE
MEDIA, 2009-2016 ($ MILLIONS) 111
POWDERED AND LIQUID MEDIA 111
Market Revenue 112
TABLE 49 U S MARKET FOR POWDERED AND LIQUID MEDIA,
THROUGH 2016 ($ MILLIONS) 112
FIGURE 25 U S MARKET FOR POWDERED AND LIQUID MEDIA,
2009-2016 ($ MILLIONS) 113
CLASSICAL AND SPECIALTY MEDIA 113
Market Revenue 114
TABLE 50 U S MARKET FOR CLASSICAL AND SPECIALTY MEDIA,
THROUGH 2016 ($ MILLIONS) 114
FIGURE 26 U S MARKET FOR CLASSICAL AND SPECIALTY MEDIA,
2009-2016 ($ MILLIONS) 114
SERA 115
MARKET OVERVIEW 115
MARKET REVENUE 116
TABLE 51 U S MARKET FOR BOVINE AND OTHER SERA,
THROUGH 2016 ($ MILLIONS) 116
FIGURE 27 U S MARKET FOR BOVINE AND OTHER SERA,
THROUGH 2016 ($ MILLIONS) 117
REAGENTS 117
MARKET OVERVIEW 118
Market Overview (Continued) 119
MARKET REVENUE 120
TABLE 52 U S MARKET FOR CELL CULTURE REAGENTS,
THROUGH 2016 ($ MILLIONS) 120
FIGURE 28 U S MARKET FOR CELL CULTURE REAGENTS, 2009-
2016 ($ MILLIONS) 120
BIOLOGICAL RESPONSE MODIFIERS 121
TABLE 53 U S MARKET FOR BIOLOGICAL RESPONSE MODIFIERS,
THROUGH 2016 ($ MILLIONS) 122
FIGURE 29 U S MARKET FOR BIOLOGICAL RESPONSE
MODIFIERS, 2009-2016 ($ MILLIONS) 122
U S MARKET LEADERS 123
MEDIA 123
Serum-Free Media 123
TABLE 54 U S MARKET SHARES OF SERUM-FREE MEDIA, 2010 (%) 123
FIGURE 30 U S MARKET SHARES OF SERUM-FREE MEDIA, 2010
(%) 124
Serum-Requiring/Containing Media 124
TABLE 55 U S MARKET SHARES OF SERUM-CONTAINING MEDIA,
2010 (%) 124
FIGURE 31 U S MARKET SHARES OF SERUM-CONTAINING
MEDIA, 2010 (%) 125
Powdered Media 125
TABLE 56 U S MARKET SHARES OF POWDERED MEDIA, 2010 (%) 125
FIGURE 32 U S MARKET SHARES OF POWDERED MEDIA, 2010 (%) 126
Liquid Media 126
TABLE 57 U S MARKET SHARES OF LIQUID MEDIA, 2010 (%) 126
FIGURE 33 U S MARKET SHARES OF LIQUID MEDIA, 2010 (%) 127
Classical Media 127
TABLE 58 U S MARKET SHARES OF CLASSICAL MEDIA, 2010 (%) 127
FIGURE 34 U S MARKET SHARES OF CLASSICAL MEDIA, 2010 (%) 128
Specialty Media 128
TABLE 59 U S MARKET SHARES OF SPECIALTY MEDIA, 2010 (%) 128
FIGURE 35 U S MARKET SHARES OF SPECIALTY MEDIA, 2010 (%) 129
SERA 129
Bovine Sera 129
TABLE 60 U S MARKET SHARES OF BOVINE SERA, 2010 (%) 129
FIGURE 36 U S MARKET SHARES OF BOVINE SERA, 2010 (%) 130
Other Sera 130
TABLE 61 U S MARKET SHARES OF OTHER SERA, 2010 (%) 130
FIGURE 37 U S MARKET SHARES OF OTHER SERA, 2010 (%) 131
REAGENTS 131
Biological Response Modifiers 131
TABLE 62 U S MARKET SHARES OF BIOLOGICAL RESPONSE
MODIFIERS, 2010 (%) 132
FIGURE 38 U S MARKET SHARES OF BIOLOGICAL RESPONSE
MODIFIERS, 2010 (%) 132
Cell Dissociation Reagents 132
TABLE 63 U S MARKET SHARES OF CELL DISSOCIATION
REAGENTS, 2010 (%) 133
FIGURE 39 U S MARKET SHARES OF CELL DISSOCIATION
REAGENTS, 2010 (%) 133
Other Reagents 133
TABLE 64 U S MARKET SHARES OF OTHER REAGENTS, 2010 (%) 134
FIGURE 40 U S MARKET SHARES OF OTHER REAGENTS, 2010 (%) 134
CHAPTER SIX: EUROPEAN MARKET 135
TABLE 65 EUROPEAN MARKET FOR CELL CULTURE PRODUCTS,
THROUGH 2016 ($ MILLIONS) 135
MEDIA 136
MARKET OVERVIEW 137
MARKET REVENUE 137
TABLE 66 EUROPEAN MARKET FOR CELL CULTURE MEDIA,
THROUGH 2016 ($ MILLIONS) 137
FIGURE 42 EUROPEAN MARKET FOR CELL CULTURE MEDIA, 2009-
2016 ($ MILLIONS) 138
SERUM-FREE MEDIA AND SERUM-REQUIRING MEDIA 138
Market Revenue 139
TABLE 67 EUROPEAN MARKET FOR SERUM-REQUIRING AND
SERUM-FREE MEDIA, THROUGH 2016 ($ MILLIONS) 139
FIGURE 43 EUROPEAN MARKET FOR CELL CULTURE MEDIA, 2009-
2016 ($ MILLIONS) 140
Market Revenue 140
TABLE 68 EUROPEAN MARKET FOR POWDERED AND LIQUID
MEDIA, THROUGH 2016 ($ MILLIONS) 140
FIGURE 44 EUROPEAN MARKET FOR POWDERED AND LIQUID
MEDIA, THROUGH 2016 ($ MILLIONS) 141
CLASSICAL MEDIA AND SPECIALTY MEDIA 141
Market Revenue 142
TABLE 69 EUROPEAN MARKET FOR CLASSICAL AND SPECIALTY
MEDIA, THROUGH 2016 ($ MILLIONS) 142
FIGURE 45 EUROPEAN MARKET FOR CLASSICAL AND SPECIALTY
MEDIA, THROUGH 2016 ($ MILLIONS) 142
SERA 143
MARKET OVERVIEW 143
MARKET REVENUE 143
TABLE 70 EUROPEAN MARKET FOR BOVINE AND OTHER SERA,
THROUGH 2016 ($ MILLIONS) 144
FIGURE 46 EUROPEAN MARKET FOR BOVINE AND OTHER SERA,
2009-2016 ($ MILLIONS) 144
REAGENTS 144
MARKET OVERVIEW 145
MARKET REVENUE 145
TABLE 71 EUROPEAN MARKET FOR CELL CULTURE REAGENTS,
THROUGH 2016 ($ MILLIONS) 146
FIGURE 47 EUROPEAN MARKET FOR CELL CULTURE REAGENTS,
THROUGH 2016 ($ MILLIONS) 146
BIOLOGICAL RESPONSE MODIFIERS 147
MARKET REVENUE 147
TABLE 72 EUROPEAN MARKET FOR BIOLOGICAL RESPONSE
MODIFIERS, THROUGH 2016 ($ MILLIONS) 148
FIGURE 48 EUROPEAN MARKET FOR BIOLOGICAL RESPONSE
MODIFIERS, 2009-2016 ($ MILLIONS) 148
EUROPEAN MARKET LEADERS 148
MEDIA 149
Serum-Free Media 149
TABLE 73 EUROPEAN MARKET SHARES OF SERUM-FREE MEDIA
BY COMPANY, 2010 (%) 149
FIGURE 49 EUROPEAN MARKET SHARES OF SERUM-FREE MEDIA
BY COMPANY, 2010 (%) 149
Serum-Requiring/Containing Media 150
TABLE 74 EUROPEAN MARKET SHARES OF SERUM-CONTAINING
MEDIA BY COMPANY, 2010 (%) 150
FIGURE 50 EUROPEAN MARKET SHARES OF SERUM-CONTAINING
MEDIA BY COMPANY, 2010 (%) 150
Powdered Media 151
TABLE 75 EUROPEAN MARKET SHARES OF POWDERED MEDIA BY
COMPANY, 2010 (%) 151
FIGURE 51 EUROPEAN MARKET SHARES OF POWDERED MEDIA
BY COMPANY, 2010 (%) 151
Liquid Media 152
TABLE 76 EUROPEAN MARKET SHARES OF LIQUID MEDIA BY
COMPANY, 2010 (%) 152
FIGURE 52 EUROPEAN MARKET SHARES OF LIQUID MEDIA, 2010
(%) 152
Classical Media 153
TABLE 77 EUROPEAN MARKET SHARES OF CLASSICAL MEDIA BY
COMPANY, 2010 (%) 153
FIGURE 53 EUROPEAN MARKET SHARES OF CLASSICAL MEDIA
BY COMPANY, 2010 (%) 153
Specialty Media 154
TABLE 78 EUROPEAN MARKET SHARES OF SPECIALTY MEDIA BY
COMPANY, 2010 (%) 154
FIGURE 54 EUROPEAN MARKET SHARES OF SPECIALTY MEDIA
BY COMPANY, 2010 (%) 154
SERA 155
Bovine Sera 155
TABLE 79 EUROPEAN MARKET SHARES OF BOVINE SERA BY
COMPANY, 2010 (%) 155
FIGURE 55 EUROPEAN MARKET SHARES OF BOVINE SERA BY
COMPANY, 2010 (%) 156
Other Sera 156
TABLE 80 EUROPEAN MARKET SHARES OF OTHER SERA BY
COMPANY, 2010 (%) 156
FIGURE 56 EUROPEAN MARKET SHARES OF OTHER SERA BY
COMPANY, 2010 (%) 157
REAGENTS 157
Biological Response Modifiers 157
TABLE 81 EUROPEAN MARKET SHARES OF BIOLOGICAL
RESPONSE MODIFIERS BY COMPANY, 2010 (%) 158
FIGURE 57 EUROPEAN MARKET SHARES OF BIOLOGICAL
RESPONSE MODIFIERS BY COMPANY, 2010 (%) 158
Cell Dissociation Reagents 159
TABLE 82 EUROPEAN MARKET SHARES OF CELL DISSOCIATION
REAGENTS BY COMPANY, 2010 (%) 159
FIGURE 58 EUROPEAN MARKET SHARES OF CELL DISSOCIATION
REAGENTS BY COMPANY, 2010 (%) 159
Other Reagents 160
TABLE 83 EUROPEAN MARKET SHARES OF OTHER REAGENTS BY
COMPANY, 2010 (%) 160
FIGURE 59 EUROPEAN MARKET SHARES OF OTHER REAGENTS
BY COMPANY, 2010 (%) 160
CHAPTER SEVEN: ASIAN MARKET 161
TABLE 84 ASIAN MARKET FOR CELL CULTURE PRODUCTS,
THROUGH 2016 ($ MILLIONS) 162
FIGURE 60 ASIAN MARKET FOR CELL CULTURE PRODUCTS,
THROUGH 2016 ($ MILLIONS) 162
MEDIA 163
MARKET OVERVIEW 163
MARKET REVENUE 164
TABLE 85 ASIAN MARKET FOR CELL CULTURE MEDIA, THROUGH
2016 ($ MILLIONS) 164
FIGURE 61 ASIAN MARKET FOR CELL CULTURE MEDIA,
THROUGH 2016 ($ MILLIONS) 164
SERUM-FREE MEDIA AND SERUM-REQUIRING MEDIA 165
Market Revenue 165
TABLE 86 ASIAN MARKET FOR SERUM-REQUIRING AND SERUMFREE
MEDIA, THROUGH 2016 ($ MILLIONS) 165
FIGURE 62 ASIAN MARKET FOR SERUM-REQUIRING AND SERUMFREE
MEDIA, 2009-2016 ($ MILLIONS) 166
POWDERED AND LIQUID MEDIA 166
Market Revenue 167
TABLE 87 ASIAN MARKET FOR POWDERED AND LIQUID MEDIA,
THROUGH 2016 ($ MILLIONS) 167
FIGURE 63 ASIAN MARKET FOR POWDERED AND LIQUID MEDIA,
THROUGH 2016 ($ MILLIONS) 167
CLASSICAL MEDIA AND SPECIALTY MEDIA 168
Market Revenue 168
TABLE 88 ASIAN MARKET FOR CLASSICAL AND SPECIALTY
MEDIA, THROUGH 2016 ($ MILLIONS) 169
FIGURE 64 ASIAN MARKET FOR CLASSICAL AND SPECIALTY
MEDIA, THROUGH 2016 ($ MILLIONS) 169
SERA 170
MARKET OVERVIEW 170
MARKET REVENUE 171
TABLE 89 ASIAN MARKET FOR BOVINE AND OTHER SERA,
THROUGH 2016 ($ MILLIONS) 171
FIGURE 65 ASIAN MARKET FOR BOVINE AND OTHER SERA, 2009-
2016 ($ MILLIONS) 171
REAGENTS 172
MARKET OVERVIEW 172
Market Revenue 173
TABLE 90 ASIAN MARKET FOR CELL CULTURE REAGENTS,
THROUGH 2016 ($ MILLIONS) 173
FIGURE 66 ASIAN MARKET FOR CELL CULTURE REAGENTS,
THROUGH 2016 ($ MILLIONS) 174
BIOLOGICAL RESPONSE MODIFIERS 174
Market Revenue 174
TABLE 91 ASIAN MARKET FOR BIOLOGICAL RESPONSE
MODIFIERS, THROUGH 2016 ($ MILLIONS) 175
FIGURE 67 ASIAN MARKET FOR BIOLOGICAL RESPONSE
MODIFIERS, 2009-2016 ($ MILLIONS) 175
ASIAN MARKET LEADERS 175
MEDIA 176
Serum-Free Media 176
TABLE 92 ASIAN MARKET SHARES OF SERUM-FREE MEDIA BY
COMPANY, 2010 (%) 176
FIGURE 68 ASIAN MARKET SHARES OF SERUM-FREE MEDIA BY
COMPANY, 2010 (%) 176
Serum-Requiring/Containing Media 177
TABLE 93 ASIAN MARKET SHARES OF SERUM-CONTAINING
MEDIA BY COMPANY, 2010 (%) 177
FIGURE 69 ASIAN MARKET SHARES OF SERUM CONTAINING
MEDIA BY COMPANY, 2010 (%) 177
Powdered Media 178
TABLE 94 ASIAN MARKET SHARES OF POWDERED MEDIA BY
COMPANY, 2010 (%) 178
FIGURE 70 ASIAN MARKET SHARES OF POWDERED MEDIA BY
COMPANY, 2010 (%) 178
Liquid Media 179
TABLE 95 ASIAN MARKET SHARES OF LIQUID MEDIA BY
COMPANY, 2010 (%) 179
FIGURE 71 ASIAN MARKET SHARES OF LIQUID MEDIA BY
COMPANY, 2010 (%) 179
Classical Media 180
TABLE 96 ASIAN MARKET SHARES OF CLASSICAL MEDIA BY
COMPANY, 2010 (%) 180
FIGURE 72 ASIAN MARKET SHARES OF CLASSICAL MEDIA BY
COMPANY, 2010 (%) 180
Specialty Media 181
TABLE 97 ASIAN MARKET SHARES OF SPECIALTY MEDIA BY
COMPANY, 2010 (%) 181
FIGURE 73 ASIAN MARKET SHARES OF SPECIALTY MEDIA BY
COMPANY, 2010 (%) 181
SERA 182
Bovine Sera 182
TABLE 98 ASIAN MARKET SHARES OF BOVINE SERA BY
COMPANY, 2010 (%) 182
FIGURE 74 ASIAN MARKET SHARES OF BOVINE SERA BY
COMPANY, 2010 (%) 182
Other Sera 183
TABLE 99 ASIAN MARKET SHARES OF OTHER SERA BY COMPANY,
2010 (%) 183
FIGURE 75 ASIAN MARKET SHARES OF OTHER SERA BY
COMPANY, 2010 (%) 183
REAGENTS 184
Biological Response Modifiers 184
TABLE 100 ASIAN MARKET SHARES OF BIOLOGICAL RESPONSE
MODIFIERS BY COMPANY, 2010 (%) 184
FIGURE 76 ASIAN MARKET SHARES OF BIOLOGICAL RESPONSE
MODIFIERS BY COMPANY, 2010 (%) 185
Cell Dissociation Reagents 185
TABLE 101 ASIAN MARKET SHARES OF CELL DISSOCIATION
REAGENTS BY COMPANY, 2010 (%) 185
FIGURE 77 ASIAN MARKET SHARES OF CELL DISSOCIATION
REAGENTS BY COMPANY, 2010 (%) 186
Other Reagents 186
TABLE 102 ASIAN MARKET SHARES OF OTHER REAGENTS BY
COMPANY, 2010 (%) 186
FIGURE 78 ASIAN MARKET SHARES OF OTHER REAGENTS BY
COMPANY, 2010 (%) 187
CHAPTER EIGHT: EMERGING MARKETS/REST OF THE WORLD
MARKET 188
TABLE 103 EMERGING MARKETS FOR CELL CULTURE PRODUCTS,
THROUGH 2016 ($ MILLIONS) 188
FIGURE 79 EMERGING MARKETS FOR CELL CULTURE
PRODUCTS, 2009-2016 ($ MILLIONS) 189
MEDIA 189
MARKET OVERVIEW 190
Market Revenue 190
TABLE 104 EMERGING MARKETS FOR CELL CULTURE MEDIA,
THROUGH 2016 ($ MILLIONS) 191
FIGURE 80 EMERGING MARKETS FOR CELL CULTURE MEDIA,
2009-2016 ($ MILLIONS) 191
SERUM-FREE AND SERUM-REQUIRING MEDIA 192
Market Revenue 192
TABLE 105 EMERGING MARKETS FOR SERUM-REQUIRING AND
SERUM-FREE MEDIA, THROUGH 2016 ($ MILLIONS) 192
FIGURE 81 EMERGING MARKETS FOR SERUM-REQUIRING AND
SERUM-FREE MEDIA, THROUGH 2016 ($ MILLIONS) 193
POWDERED AND LIQUID MEDIA 193
Market Revenue 193
TABLE 106 EMERGING MARKETS FOR POWDERED AND LIQUID
MEDIA, THROUGH 2016 ($ MILLIONS) 194
FIGURE 82 EMERGING MARKETS FOR POWDERED AND LIQUID
MEDIA, 2009-2016 ($ MILLIONS) 194
CLASSICAL MEDIA AND SPECIALTY MEDIA 194
Market Revenue 195
TABLE 107 EMERGING MARKETS FOR CLASSICAL AND
SPECIALTY MEDIA, THROUGH 2016 ($ MILLIONS) 195
FIGURE 83 EMERGING MARKETS FOR CLASSICAL AND
SPECIALTY MEDIA, 2009 2016 ($ MILLIONS) 195
SERA 196
MARKET OVERVIEW 196
MARKET REVENUE 196
TABLE 108 EMERGING MARKETS FOR BOVINE AND OTHER SERA,
THROUGH 2016 ($ MILLIONS) 197
FIGURE 84 EMERGING MARKETS FOR BOVINE AND OTHER SERA,
2009-2016 ($ MILLIONS) 197
REAGENTS 197
MARKET OVERVIEW 198
MARKET REVENUE 198
TABLE 109 EMERGING MARKETS FOR CELL CULTURE REAGENTS,
THROUGH 2016 ($ MILLIONS) 199
FIGURE 85 EMERGING MARKETS FOR CELL CULTURE
REAGENTS, 2009-2016 ($ MILLIONS) 199
BIOLOGICAL RESPONSE MODIFIERS 200
Market Revenue 200
TABLE 110 EMERGING MARKETS FOR BIOLOGICAL RESPONSE
MODIFIERS, THROUGH 2016 ($ MILLIONS) 200
FIGURE 86 EMERGING MARKETS FOR BIOLOGICAL RESPONSE
MODIFIERS, 2009-2016 ($ MILLIONS) 201
MARKET LEADERS IN THE EMERGING MARKETS 201
MEDIA 201
Serum-Free Media 201
TABLE 111 MARKET SHARES OF SERUM FREE MEDIA IN THE
EMERGING MARKETS BY COMPANY, 2010 (%) 202
FIGURE 87 MARKET SHARES OF SERUM FREE MEDIA IN THE
EMERGING MARKETS BY COMPANY, 2010 (%) 202
Serum-Requiring/Containing Media 202
TABLE 112 MARKET SHARES OF SERUM-CONTAINING MEDIA IN
THE EMERGING MARKETS BY COMPANY, 2010 (%) 203
FIGURE 88 MARKET SHARES OF SERUM CONTAINING MEDIA IN
THE EMERGING MARKETS BY COMPANY, 2010 (%) 203
Powdered Media 204
TABLE 113 MARKET SHARES OF POWDERED MEDIA IN THE
EMERGING MARKETS BY COMPANY, 2010 (%) 204
FIGURE 89 MARKET SHARES OF POWDERED MEDIA IN THE
EMERGING MARKETS BY COMPANY, 2010 (%) 204
Liquid Media 205
TABLE 114 MARKET SHARES OF LIQUID MEDIA IN THE
EMERGING MARKETS BY COMPANY, 2010 (%) 205
FIGURE 90 MARKET SHARES OF LIQUID MEDIA IN THE
EMERGING MARKETS BY COMPANY, 2010 (%) 205
Classical Media 206
TABLE 115 MARKET SHARES OF CLASSICAL MEDIA IN THE
EMERGING MARKETS BY COMPANY, 2010 (%) 206
FIGURE 91 MARKET SHARES OF CLASSICAL MEDIA IN THE
EMERGING MARKETS BY COMPANY, 2010 (%) 206
Specialty Media 207
TABLE 116 MARKET SHARES OF SPECIALTY MEDIA IN THE
EMERGING MARKETS BY COMPANY, 2010 (%) 207
FIGURE 92 MARKET SHARES OF SPECIALTY MEDIA IN THE
EMERGING MARKETS BY COMPANY, 2010 (%) 207
SERA 208
Bovine Sera 208
TABLE 117 MARKET SHARES OF BOVINE SERA IN THE EMERGING
MARKETS BY COMPANY, 2010 (%) 208
FIGURE 93 MARKET SHARES OF BOVINE SERA IN THE EMERGING
MARKETS BY COMPANY, 2010 (%) 208
Other Sera 209
TABLE 118 MARKET SHARES OF OTHER SERA IN THE EMERGING
MARKETS BY COMPANY, 2010 (%) 209
FIGURE 94 MARKET SHARES OF OTHER SERA IN THE EMERGING
MARKETS BY COMPANY, 2010 (%) 209
REAGENTS 210
Biological Response Modifiers 210
TABLE 119 MARKET SHARES OF BIOLOGICAL RESPONSE
MODIFIERS IN THE EMERGING MARKETS BY COMPANY, 2010
(%) 210
FIGURE 95 MARKET SHARES OF BIOLOGICAL RESPONSE
MODIFIERS IN THE EMERGING MARKETS BY COMPANY, 2010
(%) 211
Cell Dissociation Reagents 211
TABLE 120 MARKET SHARES OF CELL DISSOCIATION REAGENTS
IN THE EMERGING MARKETS BY COMPANY, 2010 (%) 211
FIGURE 96 MARKET SHARES OF CELL DISSOCIATION REAGENTS
IN THE EMERGING MARKETS BY COMPANY, 2010 (%) 212
Other Reagents 212
TABLE 121 MARKET SHARES OF OTHER REAGENTS IN THE
EMERGING MARKETS BY COMPANY, 2010 (%) 213
FIGURE 97 MARKET SHARES OF OTHER REAGENTS IN THE
EMERGING MARKETS BY COMPANY, 2010 (%) 213
CHAPTER NINE: END USERS 214
MARKET SHARE OF APPLICATIONS 214
TABLE 122 GLOBAL MEDIA, SERA AND REAGENT MARKET
SHARES BY END USER, 2010 (%) 215
FIGURE 98 GLOBAL MEDIA, SERA AND REAGENT MARKET
SHARES BY END USER, 2010 (%) 215
RESEARCH SEGMENT 215
RESEARCH SEGMENT (CONTINUED) 216
RESEARCH SEGMENT (CONTINUED) 217
MARKET REVENUE 218
TABLE 123 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN
THE RESEARCH SEGMENT, THROUGH 2016 ($ MILLIONS) 218
FIGURE 99 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN
THE RESEARCH SEGMENT, 2009-2016 ($ MILLIONS) 219
PRODUCTION SEGMENT 219
PRODUCTION SEGMENT (CONTINUED) 220
MARKET REVENUE 221
TABLE 124 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN
THE PRODUCTION SEGMENT, THROUGH 2016 ($ MILLIONS) 221
FIGURE 100 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN
THE PRODUCTION SEGMENT, 2009-2016 ($ MILLIONS) 222
CONTRACT SEGMENT 222
CONTRACT SEGMENT (CONTINUED) 223
MARKET REVENUE 224
TABLE 125 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN
THE CONTRACT SEGMENT, THROUGH 2016 ($ MILLIONS) 225
FIGURE 101 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN
THE CONTRACT SEGMENT, 2009-2016 ($ MILLIONS) 225
OTHERS SEGMENT 225
MARKET REVENUE 226
TABLE 126 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN
THE OTHERS SEGMENT, THROUGH 2016 ($ MILLIONS) 227
FIGURE 102 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN
THE OTHERS SEGMENT, 2009-2016 ($ MILLIONS) 227
CHAPTER TEN: PATENT ANALYSIS 228
PATENTS BY YEAR 228
TABLE 127 NUMBER OF U S PATENTS ISSUED BY YEAR, 2007 TO
OCT 2011 229
FIGURE 103 U S PATENTS ISSUED BY YEAR, 2007 TO OCT 2011 (%) 229
PATENTS BY TYPE 229
TABLE 128 PATENTS BY TYPE FOR MEDIA, SERA AND REAGENTS
USED IN BIOTECHNOLOGY, 2007-2011 230
FIGURE 104 PATENTS BY TYPE FOR MEDIA, SERA AND REAGENTS
USED IN BIOTECHNOLOGY, 2007-2011 (NO OF PATENTS) 230
PATENTS BY COMPANY 230
TABLE 129 U S PATENTS ISSUED FOR MEDIA, SERA AND
REAGENTS IN BIOTECHNOLOGY BY COMPANY, 2007 TO OCT
2011 (NO ) 231
PATENTS BY COUNTRY 232
TABLE 130 U S PATENTS ISSUED FOR MEDIA, SERA AND
REAGENTS USED IN BIOTECHNOLOGY BY COUNTRY, 2007 TO
OCT 2011 (NO ) 232
TABLE 131 SHARES OF U S PATENTS ISSUED FOR MEDIA, SERA
AND REAGENTS USED IN BIOTECHNOLOGY BY COUNTRY,
2007-OCT 2011 (%) 233
PATENTS BY ASSIGNEE 233
TABLE 132 U S PATENTS ISSUED FOR MEDIA, SERA AND
REAGENTS USED IN BIOTECHNOLOGY BY TYPE OF END USER,
2007 TO OCT 2011 (NO ) 233
CHAPTER ELEVEN: THE CURRENT SITUATION 234
REGIONAL MARKETS 234
UNITED STATES 234
EUROPE 235
ASIA 235
EMERGING MARKETS 236
TRENDS AND ISSUES IN THE CELL CULTURE MARKET 236
GLOBAL ECONOMY 236
INCREASED RESEARCH AND DEVELOPMENT BUDGET 236
TABLE 133 RandD BUDGETS OF TOP 10 COMPANIES IN 2009 AND
2010 ($ BILLIONS) 237
GROWING DEMAND AND RICH PIPELINE OF
BIOTHERAPEUTICS 237
RESEARCH ON THERAPEUTIC VACCINES 238
BIOMEDICAL RESEARCH 239
STEM CELL RESEARCH 239
GOVERNMENT POLICIES ON RESEARCH 239
INNOVATIONS 240
ETHICAL AND ANIMAL WELFARE ISSUES 240
REGULATORY ISSUES 241
USE OF HUMAN BLOOD ALTERNATIVES 241
MERGERS, ACQUISITIONS AND ALLIANCES 242
SHIFT TOWARD CONTRACT MANUFACTURING 242
CHAPTER TWELVE: COMPANY PROFILES 243
ADVANCED BIOTECHNOLOGIES INC 243
AFFYMETRIX 243
AMRESCO LLC 244
ATHENA ENVIRONMENTAL SCIENCES INC 244
ATLANTA BIOLOGICALS INC 245
BD BIOSCIENCES 246
BIORECLAMATION INC 246
BOVOGEN BIOLOGICALS PTY LTD 247
CELL APPLICATIONS INC 247
CELL CULTURE TECHNOLOGIES GMBH 248
CLONTECH LABORATORIES INC 249
EQUITECH-BIO INC 249
GEMINI BIO-PRODUCTS 250
GENEX INDIA BIOSCIENCES PVT LTD 250
HIMEDIA LABORATORIES 251
INVITROGEN CORP 251
IRVINE SCIENTIFIC 252
J R SCIENTIFIC INC 253
LONZA 253
MEDIATECH INC 254
MEDOX BIOTECH INDIA PVT LTD 254
MILLIPORE CORP 255
MP BIOMEDICALS 256
PAA LABORATORIES 257
PEPROTECH INC 257
PROMOCELL GMBH 258
QUALITY BIOLOGICAL INC 258
RandD SYSTEMS 259
ROCHE APPLIED SCIENCES 260
SERA LABORATORIES INTERNATIONAL LTD 260
SERACARE LIFE SCIENCES INC 261
SIGMA-ALDRICH 261
STEMCELL TECHNOLOGIES 262
STEMCELLS INC 262
THERMO FISHER SCIENTIFIC INC 263
TICO EUROPE 264
VALLEY BIOMEDICAL PRODUCTS AND SERVICES INC 265
APPENDIX: ABBREVIATIONS 266
ABBREVIATIONS (CONTINUED) 267
ABBREVIATIONS (CONTINUED) 268

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