The Impact of Nanotechnology on the Life Sciences and Healthcare Market to 2015

The Impact of Nanotechnology on the Life Sciences and Healthcare Market to 2015

One of the most active and important current areas of research and application of nanotechnology is in the field of life sciences and healthcare. Many industry and business analysts now expect nanotechnology to revolutionize the pharmaceutical, medical devices, diagnostics and imaging sectors with annual markets of billions of pounds likely within five-ten years. Nanotechnologies for Life Sciences and Healthcare includes:

- Analysis of key nanotechnologies and commercialization activity thereof
- Analysis of impact of nanotechnology on the life science and healthcare markets to 2015
- Analysis of most promising product areas in Pharmaceuticals, Drug Delivery, Medical Supplies and Devices, Implants, Coatings, Wound Care, Diagnostics, Non-Invasive Therapy, Imaging and Tissue Engineering.
- Profiles of companies and research centres developing nanotechnologies for commercial application in Life Sciences and Healthcare

1 INTRODUCTION 9
1.1 Nanotechnology in Life Sciences and Healthcare 9
1.2 Key applications and market opportunity to 2015 11
1.2.1 Global revenue forecasts 11
1.2.2 Market for nanomaterials in life sciences and healthcare 14
1.2.2.1 Nanoscale biosensors 14
1.2.2.2 Molecular imaging 16
1.2.2.3 Nanocoatings on surfaces and implants 17
1.2.2.4 Nanoparticulate drug delivery 18
1.3 Key Players 19
2 KEY NANOTECHNOLOGIES 22
2.1 NANOPARTICLES 23
2.1.1 Market for nanoparticles 24
2.1.2 Key players 26
2.1.2.1 Manufacturers and End Users 26
2.1.2.2 Nanomaterials suppliers 27
2.1.2.3 Application manufacturers 27
2.2 NANOCAPSULES 29
2.2.1 Market for nanocapsules 29
2.2.2 Key players 31
2.2.2.1 Manufacturers and End Users 31
2.2.2.2 Nanomaterials suppliers 32
2.2.2.3 Application manufacturers 32
2.3 NANOPOROUS MATERIALS 33
2.3.1 Market for nanoporous materials 33
2.3.2 Key Players 36
2.3.2.1 Manufacturers and End Users 36
2.3.2.2 Nanomaterials suppliers 36
2.3.2.3 Application manufacturers 37
2.4 QUANTUM DOTS 38
2.4.1 Market for quantum dots 38
2.4.2 Key players 40
2.4.2.1 Manufacturers and End Users 40
2.4.2.2 Nanomaterials suppliers 40
2.4.2.3 Application manufacturers 40
2.5 NANOCOATINGS 41
2.5.1 Market for Nanocoatings 41
2.5.2 Key players 43
2.5.2.1 Manufacturers and End Users 43
2.5.2.2 Nanomaterials suppliers 44
2.5.2.3 Application manufacturers 44
3 PHARMACEUTICALS 46
3.1 FORMULATION 46
3.1.1 TECHNOLOGY PROVIDERS 47
3.1.1.1 Fluorescently encoded microparticles for multiple analysis and design of drug delivery 47
3.1.1.2 Pharmaceutical formulations of nanoparticulate systems 47
3.1.1.3 Formulation of pharmaceutical compounds at the nanoscale 48
3.1.1.4 Fluoropolymer materials platform for drug therapy 48
3.1.1.5 Nanotechnology to accelerate the chiral drug development process 50
3.1.1.6 DNA nanoparticle technologies to produce safe and effective DNA drugs 51
3.1.1.7 Cell based electrophysiology chip for the discovery of drugs for ion channel diseases 52
3.1.1.8 Drug profiling using smart materials 53
3.1.1.9 Nanoemulsions 54
3.1.1.10 Water-based materials using nanotechnology to enhance bioavailability and solubility of existing and new drugs 55
3.1.1.11 Supercritical fluids for enhancing solubility and bioavailability 56
3.1.1.12 Dendrimer nanotechnology products for pharmaceuticals 57
3.1.1.13 Novel method and formulation of drugs to treat and reduce the spread of respiratory infections 57
3.2 DRUG DELIVERY 60
3.2.1 TECHNOLOGY PROVIDERS 61
3.2.1.1 Nano-device platform for various encapsulation applications 61
3.2.1.2 Responsive nanoparticles for drug delivery 63
3.2.1.3 Nanoscale cochleate drug delivery 64
3.2.1.4 Nanoencapsulated anti-cancer drugs 65
3.2.1.5 Nanoparticle cancer treatment and therapeutic vaccines 66
3.2.1.6 Nanotechnology-based delivery platforms for vaccines and therapeutics 68
3.2.1.7 Marine extracted nano injectors for delivering drugs into the epidermis skin layer 68
3.2.1.8 Porous nanoparticles for various encapsulation applications 69
3.2.1.9 Nanoscale therapeutic anti-bodies 71
3.2.1.10 Nano carriers 72
3.2.1.11 Nanocrystals for drug delivery 73
3.2.1.12 Drug delivery coatings 74
3.2.1.13 Nanocapsules 75
3.2.1.14 Characterization of dynamic colloidal structures 75
3.2.1.15 Nanocapsulation of different oily and water-soluble substances 76
3.2.1.16 New treatments for cancer based on nano and bio 76
3.2.1.17 Nanoparticle anti-cancer agents 77
3.2.1.18 Nanoencapsulation for delivery of active ingredients 80
3.2.1.19 Micro-needle arrays 81
3.2.1.20 Nanopores for brachytherapy, inhalation, transdermal and implant delivery methods 83
3.2.1.21 New micro spraying systems for drug delivery 84
3.2.1.22 Delivery systems based on coated nanomaterials 84
3.2.1.23 Creation of nutritional, clinical nutrition and drug delivery systems based on carbohydrates 85
3.2.1.24 Carbon nanotubes for life science applications 86
3.2.1.25 Nanoparticle coated microcrystals 89
3.2.1.26 Smart materials for encapsulation 90
3.2.1.27 University 5 UK: Novel chemical method of making hollow spherical silica shells 90
3.2.1.28 Stealth particles’ fabricated and coated with surfactants and phosolipids 92
3.2.1.29 University 7 UK: Controlling the delivery of small molecules from nanoporous solids 92
3.2.1.30 Controlled release from layered materials 93
3.2.1.31 Smart materials for encapsulation 93
3.2.1.32 Anti-microbial nanoencapsulation 94
3.2.1.33 University 11 UK: Anti-microbial encapsulation 94
3.2.1.34 Nanocomposite controlled release 95
4 MEDICAL SUPPLIES AND DEVICES 98
4.1 IMPLANTS 98
4.1.1 TECHNOLOGY PROVIDERS 99
4.1.1.1 Hydroxyapatite nanoparticles for bone graft substitutes 99
4.1.1.2 Stimulation electrodes using nanotechnology 100
4.1.1.3 Sol gel coatings for synthetic bone graft substitutes 101
4.1.1.4 Implantable life supporting devices using novel biocompatible polymeric materials 102
4.1.1.5 Nano-titania implants 102
4.1.1.6 Nanocoating of drug eluting stents and orthopaedic implants 103
4.1.1.7 Dental implant coated by a nanostructured titanium oxide film 105
4.1.1.8 Stetch receptors for prosthesis 107
4.1.1.9 Nanocoatings for medical implants 108
4.1.1.10 Anti-microbial resistant surfaces for medical implants 108
4.2 MEDICAL DEVICE COATINGS 110
4.2.1 TECHNOLOGY PROVIDERS 111
4.2.1.1 Nanoscale plasma coating for medical devices 111
4.2.1.2 Light activated anti-microbials 111
4.2.1.3 Silver nanoparticle antimicrobial surface treatment for medical devices 112
4.2.1.4 Coatings for medical devices 113
4.2.1.5 Easy-to-clean hydrophobic coatings 115
4.2.1.6 Biocompatible nanocoatings 116
4.2.1.7 Bioactive coatings 118
4.2.1.8 Nanostructured surfaces and textures 118
4.2.1.9 Sol-Gel based multifunctional coatings for medical applications 119
4.2.1.10 Anti-fouling nanocoatings 119
4.2.1.11 Passive, nano-film hydroxyapatite coating for drug-eluding stents 120
4.2.1.12 Anti-biofilm compounds 122
4.2.1.13 Anti-microbial metal ion delivery from water soluble glass 124
4.2.1.14 Nanocoatings for surface functionalization 124
4.2.1.15 Modification and characterization of polymeric, metallic and ceramic material surfaces 127
4.2.1.16 Hydrogels and nano-carriers 128
4.2.1.17 Method for disinfecting small water lines 128
4.2.1.18 Nanotechnology for hygienic surfaces 130
4.2.1.19 Non-stick nanoparticulate coating that prevents bacteria and other living cells from 131
4.2.1.20 Nanostructured anti-bacterial surfaces 133
4.3 WOUND CARE 134
4.3.1 TECHNOLOGY PROVIDERS 135
4.3.1.1 Nanosilver and nanogold gels for anti-microbial burn and wound dressings 135
4.3.1.2 Textiles for wound dressing 136
4.3.1.3 Controlled release bandages medical dressings 136
5 DIAGNOSTICS AND THERAPIES 138
5.1.1 TECHNOLOGY PROVIDERS 139
5.1.1.1 Nanoparticles with functional properties for biochemical applications 139
5.1.1.2 Bioseparation gene transfection and detection systems 140
5.1.1.3 Genome sequencing via synthesis of nucleic acids 140
5.1.1.4 Minimally invasive cancer therapy 141
5.1.1.5 Novel nano-engineered material surfaces for the bio-molecular attachment and detection 142
5.1.1.6 Magnetic nanoparticles for rare cell isolation 143
5.1.1.7 Iron oxide nanoparticles to treat anemia 144
5.1.1.8 Fluorescent markers for use in biological research and testing 144
5.1.1.9 Therapeutics from its polymeric nanoparticle technology platform 145
5.1.1.10 Nanotransponders 146
5.1.1.11 Liquid crystals for the rapid detection of molecular interactions 147
5.1.1.12 Non-invasive medical therapies using patented nanoparticles 148
5.1.1.13 Non-invasive product that kills cancer using localized lethal heat 148
5.1.1.14 Nanosensors and devices 150
5.1.1.15 Nanobiosensors 151
5.1.1.16 Nanoarray biochips 152
5.1.1.17 Medical diagnostic imaging 153
5.1.1.18 Immunoassays for automated biochemistry analysers. 155
5.1.1.19 Smart card diagnostics 155
5.1.1.20 Reagents for immunoturbidimetry 156
5.1.1.21 Nanosensors and nano biosensors 157
5.1.1.22 Nanosensors 158
5.1.1.23 Nanowire biosensors 159
5.1.1.24 Silicon-based chips/sensors for pH and pressure 160
5.1.1.25 Novel microfluidic technology 161
5.1.1.26 Micro- and nano-replication 163
5.1.1.27 Top-down approach for designing optical nano-biosensors and biochips “on-demand” 164
5.1.1.28 Encapsulation of radioactive nanoparticle for diagnostic and curative purposes 168
5.1.1.29 Redox enzymes 169
5.1.1.30 Nanocells 170
5.1.1.31 Nanoscale biosensors for pathogen detection and diagnosis 172
6 REGENERATIVE MEDICINE 175
6.1 TISSUE ENGINEERING 176
6.1.1 TECHNOLOGY PROVIDERS 176
6.1.1.1 Nanostructured hydroxyapatite for tissue engineering 176
6.1.1.2 Nanoemulsions capable of targeting and binding to the specific receptors of LDL existing on the surface of cellular membranes 176
6.1.1.3 Control of the regeneration of diseased tissue 177
6.1.1.4 Self-assembling nanoscale scaffolds 179
6.1.1.5 Nano grafting of combinatorial polymer brushes 180
6.1.1.6 Tissue engineering products utilising magnetic nanoparticles 181
6.1.1.7 Nano wrinkles of scaffolding for controlled cell growth 183
6.1.1.8 Fabrication of synthetic biomaterials that induce a cellular response similar to that found in-vivo 184
7 GLOSSARY OF TERMS 185