World Pain Management Markets

World Pain Management Markets

This report analyzes the worldwide markets for Pain Management in Millions of US$. The specific product segments analyzed are Pain Management Pharmaceuticals, Pain Management Devices, and Pain Management Services. The report provides separate comprehensive analytics for the US, Canada, Japan, Europe, Asia-Pacific, Latin America, and Rest of World. Annual forecasts are provided for each region for the period of 2001 through 2010. A ten-year historic analysis is also provided for these markets with annual market analytics. The report profiles 131 companies including many key and niche players worldwide such as AstraZeneca PLC, Elan Corporation PLC, Eli Lilly and Company, Glaxo Smithkline Plc, Johnson & Johnson, Merck & Co., Inc., Novartis Pharmaceuticals Corporation, Organon International, Inc., Pfizer, Inc., Purdue Pharma, Sanofi Aventis, and Wyeth. Market data and analytics are derived from primary and secondary research. Company profiles are mostly extracted from URL research and reported select online sources.

CONTENTS


I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

Study Reliability and Reporting Limitations I-1
Disclaimers I-2
Data Interpretation & Reporting Level I-2
CAGR Disparities Between Historic & Current Data I-2
Quantitative Techniques & Analytics I-3
Product Definitions and Scope of Study I-3
Pain Management Pharmaceuticals I-4
Pain Management Pharmaceuticals I-4
Pain Management Services I-4

II. EXECUTIVE SUMMARY

1. Industry Overview II-1
Pain Management Market to Witness Steady Growth II-1
Factors Affecting Pain Management Industry II-1
Challenges Faced II-2
Trends and Issues II-2
Generic Drugs Hogs Limelight II-2
Cox II Crisis Tarnishes Industry Growth II-2
Novel Therapies to Propel Opioid and Non- Opioid Therapies II-3
Neuropathic Pain - Still an Underserved Market II-3
Cyclin-dependent kinase 5 (Cdk5) II-4
Drug Dynamics in the Migraine Market II-4
Pain Pathways - Gain a Second Look II-5
Leading Players II-6
Table 1: Leading Players in the Global Pain Management
Pharmaceuticals Market (2006): Market Share by Sales for
Pfizer, Johnson & Johnson, Novartis, GlaxoSmithkline, and
Others (includes corresponding Graph/Chart) II-6
Status of Major Pipeline Drugs for Pain Management: 2007 II-6

2. Product Overview II-7
Pain Management: An Overview II-7
Managing Pain II-7
What is Pain? II-7
Assessment of Pain II-7
Pain Management II-8
Pain Management for Neonates II-8
Pain Management in Kids II-9
Pain Management in Older Adult Surgical Patients II-9
Pain Therapeutics - An Introduction II-10
Treatment of Pain II-10
Pharmacologic Method II-10
Non-pharmacological Method II-11
Invasive Procedures II-12
Palliative Care II-12
Alternative Methods II-13
Acupuncture II-13
Biofeedback II-13
Bioelectromagnetic Therapy II-13
Biomagnetism and Magnetotherapy II-13
Guided Imagery II-14
Manual/Massage Therapies II-14
Aromatherapy Massage II-14
Swedish Massage II-14
Deep Tissue Massage II-14
Neuromuscular Therapy II-14
Myofascial Release II-14
Manual Lymph Drainage II-15
Cranial Sacral Therapy II-15
Reflexology II-15
Naturopathy II-15
Relaxation Therapy II-16
Transcendental Meditation II-16
Classification of Pain II-16
Acute Pain II-16
Postoperative pain II-17
Labor pain II-17
Visceral pain II-17
Migraine II-17
Treatment of Migraine II-17
Chronic Pain II-18
Cancer pain II-18
Back Pain II-18
Neuropathic Pain II-19
Arthritic Pain II-19
HIV-Related Pain II-19
Diabetic Neuropathy II-20
Osteo-and Rheumatoid Arthritis Pain II-20
Pain Management Products and Services II-21
Pain Management Pharmaceuticals II-21
Nonprescription Drugs II-21
Acetaminophen II-21
Aspirin II-21
Ibuprofen II-21
Ketoprofen II-21
Naproxen II-21
Pramoxine II-22
Counterirritants II-22
Triethanolamine Salicylate (Trolamine) II-22
Prescription Drugs II-22
General Anesthetics II-22
Local Anesthetics II-22
Non-steroidal Anti-Inflammatories (NSAIDs) II-23
Non-opioid Analgesics II-23
Opioid Analgesics II-23
Pain Management Devices II-25
Electrical Spinal Cord Stimulators II-25
Electrical Stimulus Devices II-26
Transcutaneous Electric Nerve Stimulators (TENS) II-26
Patient-Controlled Analgesia Infusion Devices II-26
Pain Management Services II-26
Home Care/Providence Home Health II-26
Providence Hospices II-26
Pain Management Centers and Clinics II-27
Pain Rehabilitation Programs II-27

3. Regulatory Environment II-28
An Overview of Pain Management Regulation II-28
OTC Painkillers to Carry Conspicuous Safety Warnings II-28
Federal Regulatory Norms of Controlled Substances II-29
DEA Regulations II-29

4. Product Innovations/Introductions II-30
Mallinckrodt Introduces Novel Pain Relieving Agent II-30
Shionogi Unveils Cancer Pain Management Drug II-30
NeuroTherm Launches RF Generators for Treatment of Heel Pain II-30
McNeil Brings Chewable TYLENOL® GoTabs Tablets II-30
Barr Unveils Generic Version of ACTIQ® II-30
Orthofix Unveils e-PainCare II-31
Organon Innovates Org 25969 II-31
Orthofix’s BREG Division Launches Polar Care Motorized Cold
Therapy System II-31
Zynex Develops New Pain Management Device II-31
Eli Lilly and Company Develops Cymbalta II-31
Pfizer’s Lyrica Gets Nod from the EC II-32
New Pain Management Infusion Pumps from Sorenson II-32
McKinley Unveils Accufuser Pain Management System II-32

5. Recent Industry Activity II-33
Neuromed to Acquire US Rights for Oros Hydromorphone from Alza II-33
China Aoxing to Acquire Chinese Pharmaceutical Company,
Shijiazhuang Le Ren II-33
Vyteris Holdings to Acquire Lehigh Valley Technologies II-33
Younger America Pockets Life Without Pain II-34
PainCare Divests Center for Pain Management II-34
Grand Slam Acquires IOMED II-34
Ligand Accomplishes Divesture of AVINZA II-34
CeNeS and Ergomed Collaborate for Phase II Trials of NMDA
Antagonist CNS 5161 II-34
Sorenson Secures Approval to Market Ambulatory Infusion Pump
in China II-35
PainCare Pockets CPMASC II-35
Moog Takes Over Mckinley Medical Corp II-35
PainCare Acquires REC, CareFirst Medical Associates II-35
CLL Pharma Acquires Synt:em II-36
AstraZeneca Partners with Pozen to Bring Novel Pain Management
Therapy II-36
Great Outdoors Acquires Somatic Systems Institute II-36
PainCare Partners with Solstice Neurosciences to Offer Pain
Management in CD II-36
Elan Confers Eisai with European Rights of Prialt II-36
Evotec Partners with Apeiron Biologics to Bring Novel Pain
Therapy II-36
Alpaca Enterprises Acquires Neuroscience Therapy Corp II-37
PainCare Holdings Acquires Desert Pain Medicine Group. II-37
Wex Pharma Inks Agreement With Boston Children’s Hospital II-37
Glenmark Inks Agreement with LVT to Market Pain Management
Products II-37
EKR Attains North American Marketing Rights for Gelclair II-37
Grand Slam Acquires Cefar Medical II-37
Omeros Acquires Nura II-37
Hospira Inks Agreement with Premier II-38
Pain Therapeutics Enters into Alliance with King Pharmaceuticals II-38
Corgentech Merges with AlgoRx II-38
Elder Pharmaceuticals Ventures into the Indian Pain Management
Market II-38
Xanodyne Acquires Pharmaceutical Assets of aaiPharma II-38
Pro-Dex Acquires Dental Technology From IntraVantage II-39
Encore Medical Acquires Compex Technologies II-39
Sosei Acquires Arakis II-39
Corgentech Signs Definitive Merger Agreement With AlgoRx II-39
Elder Pharmaceuticals Enters into Marketing Agreement with TRB
Chemedica II-39
University Pain Management Center Signs Agreement with Somnia II-40
Entelos and Organon to Extend Rheumatoid Arthritis (RA)
Collaboration II-40
NovaMed Establishes a New Pain Management Center at Indiana II-40
Organon and Uriach Collaborate on Developing Kinase Inhibitors II-40
Toray and Nippon To Co-Develop THCR II-41
AAIPharma Acquires Pain Products II-41
PainCare & Spine & Pain Center in a Definitive Merger Agreement II-41
Elan and Ingenium in a Strategic Alliance II-41

6. Focus on Select Key Players II-42
AstraZeneca PLC (UK) II-42
Eli Lilly and Company (USA) II-42
Glaxo Smithkline Plc (UK) II-42
Johnson & Johnson (USA) II-42
Merck & Co., Inc (USA) II-43
Novartis Pharmaceuticals Corporation (USA) II-43
Pfizer Inc. (USA) II-43
Purdue Pharma (USA) II-43
Sanofi Aventis (France) II-43
Wyeth (USA) II-44

7. Global Market Perspective II-45
Table 2: World Recent Past, Current & Future Analysis for Pain
Management by Geographic Region - US, Canada, Japan, Europe,
Asia-Pacific (excluding Japan), Latin America, and Rest of
World Markets Independently Analyzed with Annual Revenue
Figures in US$ Million for Years 2001 through 2010 (includes
corresponding Graph/Chart) II-45

Table 3: World* Recent Past, Current & Future Analysis for
Pain Management by Geographic Region - US, Canada, Japan,
Europe, Asia-Pacific (excluding Japan), Latin America, and
Rest of World Markets Independently Analyzed with Annual
Revenue Figures in US$ Million for Years 2011 through 2015
(includes corresponding Graph/Chart) II-46

Table 4: World Historic Review for Pain Management by
Geographic Region - US, Canada, Japan, Europe, Asia- Pacific
(excluding Japan), Latin America, and Rest of World Markets
Independently Analyzed with Annual Revenue Figures in US$
Million for Years 1991 through 2000 (includes corresponding
Graph/Chart) II-47

Table 5: World 20-Year Perspective for Pain Management by
Geographic Region - Percentage Breakdown of Dollar Revenue for
US, Canada, Japan, Europe, Asia-Pacific (excluding Japan),
Latin America and Rest of World Markets for Years 1991, 1997,
2007 & 2010 (includes corresponding Graph/Chart) II-48

Table 6: World Recent Past, Current & Future Analysis for Pain
Management Pharmaceuticals by Geographic Region - US, Canada,
Japan, Europe, Asia-Pacific (excluding Japan), Latin America
and Rest of World Markets Independently Analyzed with Annual
Revenue Figures in US$ Million for Years 2001 through 2010
(includes corresponding Graph/Chart) II-49

Table 7: World* Recent Past, Current & Future Analysis for
Pain Management Pharmaceuticals by Geographic Region - US,
Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin
America and Rest of World Markets Independently Analyzed with
Annual Revenue Figures in US$ Million for Years 2011 through
2015 (includes corresponding Graph/Chart) II-50

Table 8: World Historic Review for Pain Management
Pharmaceuticals by Geographic Region - US, Canada, Japan,
Europe, Asia-Pacific (excluding Japan), Latin America and Rest
of World Markets Independently Analyzed with Annual Revenue
Figures in US$ Million for Years 1991 through 2000 (includes
corresponding Graph/Chart) II-51

Table 9: World 20-Year Perspective for Pain Management
Pharmaceuticals by Geographic Region - Percentage Breakdown of
Dollar Revenue for US, Canada, Japan, Europe, Asia-Pacific
(Excluding Japan), Latin America and Rest of World Markets for
Years 1991, 1997, 2007 & 2010 (includes corresponding
Graph/Chart) II-52

Table 10: World Recent Past, Current & Future Analysis for
Pain Management Devices by Geographic Region - US, Canada,
Japan, Europe, Asia-Pacific (excluding Japan), Latin America
and Rest of World Markets Independently Analyzed with Annual
Revenue Figures in US$ Million for Years 2001 through 2010
(includes corresponding Graph/Chart) II-53

Table 11: World* Recent Past, Current & Future Analysis for
Pain Management Devices by Geographic Region - US, Canada,
Japan, Europe, Asia-Pacific (excluding Japan), Latin America
and Rest of World Markets Independently Analyzed with Annual
Revenue Figures in US$ Million for Years 2011 through 2015
(includes corresponding Graph/Chart) II-54

Table 12: World Historic Review for Pain Management Devices by
Geographic Region - US, Canada, Japan, Europe, Asia-Pacific
(excluding Japan), Latin America and Rest of World Markets
Independently Analyzed with Annual Revenue Figures in US$
Million for Years 1991 through 2000 (includes corresponding
Graph/Chart) II-55

Table 13: World 20-Year Perspective for Pain Management
Devices by Geographic Region - Percentage Breakdown of Dollar
Revenue for US, Canada, Japan, Europe, Asia-Pacific (excluding
Japan), Latin America and Rest of World Markets for Years
1991, 1997, 2007 & 2010 (includes corresponding Graph/Chart) II-56

Table 14: World Recent Past, Current & Future Analysis for
Pain Management Services by Geographic Region - US, Canada,
Japan, Europe, Asia-Pacific (excluding Japan), Latin America
and Rest of World Markets Independently Analyzed with Annual
Revenue Figures in US$ Million for Years 2001 through 2010
(includes corresponding Graph/Chart) II-57

Table 15: World Long-Term Projections for Pain Management
Services by Geographic Region - US, Canada, Japan, Europe,
Asia-Pacific (excluding Japan), Latin America and Rest of
World Markets Independently Analyzed with Annual Revenue
Figures in US$ Million for Years 2011 through 2015 (includes
corresponding Graph/Chart) II-58

Table 16: World Historic Review for Pain Management Services
by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific
(excluding Japan), Latin America and Rest of World Markets
Independently Analyzed with Annual Revenue Figures in US$
Million for Years 1991 through 2000 (includes corresponding
Graph/Chart) II-59

Table 17: World 20-Year Perspective for Pain Management
Services by Geographic Region - Percentage Breakdown of Dollar
Revenue for US, Canada, Japan, Europe, Asia-Pacific (excluding
Japan), Latin America and Rest of World Markets for Years
1991, 1997, 2007 & 2010 (includes corresponding Graph/Chart) II-60


III. MARKET

1. The United States III-1
A.Market Analysis III-1
Current & Future Analysis III-1
Pain Statistics in the US III-1
Industry Overview III-2
Measures to Thwart Drug Abuse III-2
Market for Cancer Pain Therapeutics III-2
Leading Players/Brands III-3
Table 18: Leading Oral Pain Relievers in the US Market for
Pain Management (2006) - Percentage Breakdown of Value
Sales by Brand for Orajel, Anbesol, Baby Orajel, Colgate
Peroxyl, Zilactin, Glyoxide, Hyland's, Dentek Temparin,
Orajel Mouth Aid, and Others (includes corresponding
Graph/Chart) III-3

Table 19: Leading OTC Pain Relievers in the US Market for
Pain Management (2006) - Percentage Breakdown of Value
Sales by Brand for Advil, Tylenol, Aleve, Bayer, Tylenol
PM, Motrin IB, Excedrin, Tylenol Arthritis, Excedrin
Migraine, Private label, and Others (includes
corresponding Graph/Chart) III-3
Product Launches III-4
Strategic Corporate Developments III-7
Key Players III-13
Eli Lilly and Company III-13
Johnson & Johnson III-13
Merck & Co., Inc. III-13
Novartis Pharmaceuticals Corporation III-13
Pfizer, Inc. III-14
Purdue Pharma III-14
Wyeth III-14
B.Market Analytics III-15
Table 20: US Recent Past, Current & Future Analysis for Pain
Management by Product Segment - Pain Management
Pharmaceuticals, Pain Management Devices and Pain Management
Services Markets Independently Analyzed with Annual Revenue
Figures in US$ Million for Years 2001 through 2010 (includes
corresponding Graph/Chart) III-15

Table 21: US Long-Term Projections for Pain Management by
Product Segment - Pain Management Pharmaceuticals, Pain
Management Devices and Pain Management Services Markets
Independently Analyzed with Annual Revenue Figures in US$
Million for Years 2011 through 2015 (includes corresponding
Graph/Chart) III-15

Table 22: US Historic Review for Pain Management by Product
Segment - Pain Management Pharmaceuticals, Pain Management
Devices and Pain Management Services Markets Independently
Analyzed with Annual Revenue Figures in US$ Million for
Years 1991 through 2000 (includes corresponding Graph/Chart) III-16

Table 23: US 20-Year Perspective for Pain Management by
Product Segment - Percentage Breakdown of Dollar Revenue for
Pain Management Pharmaceuticals, Pain Management Devices and
Pain Management Services Markets for 1991, 1997, 2007 & 2010
(Includes corresponding graphs/chart) III-16

2. Canada III-17
Market Analysis III-17
Table 24: Canadian Recent Past, Current & Future Analysis
for Pain Management by Product Segment - Pain Management
Pharmaceuticals, Pain Management Devices and Pain Management
Services Markets Independently Analyzed with Annual Revenue
Figures in US$ Million for Years 2001 through 2010 (includes
corresponding Graph/Chart) III-17

Table 25: Canadian Long-Term Projections for Pain Management
by Product Segment - Pain Management Pharmaceuticals, Pain
Management Devices and Pain Management Services Markets
Independently Analyzed with Annual Revenue Figures in US$
Million for Years 2011 through 2015 (includes corresponding
Graph/Chart) III-18

Table 26: Canadian Historic Review for Pain Management by
Product Segment - Pain Management Pharmaceuticals, Pain
Management Devices and Pain Management Services Markets
Independently Analyzed with Annual Revenue Figures in US$
Million for Years 1991 through 2000 (includes corresponding
Graph/Chart) III-18

Table 27: Canadian 20-Year Perspective for Pain Management
by Product Segment - Percentage Breakdown of Dollar Revenue
for Pain Management Pharmaceuticals, Pain Management Devices
and Pain Management Services Markets for 1991, 1997, 2007 &
2010 (includes corresponding Graph/Chart) III-19

3. Japan III-20
A.Market Analysis III-20
Current & Future Analysis III-20
Strategic Corporate Developments III-20
B.Market Analytics III-21
Table 28: Japanese Recent Past, Current & Future Analysis
for Pain Management by Product Segment - Pain Management
Pharmaceuticals, Pain Management Devices and Pain Management
Services Markets Independently Analyzed with Annual Revenue
Figures in US$ Million for Years 2001 through 2010 (includes
corresponding Graph/Chart) III-21

Table 29: Japanese Long-Term Projections for Pain Management
by Product Segment -Pain Management Pharmaceuticals, Pain
Management Devices and Pain Management Services Markets
Independently Analyzed with Annual Revenue Figures in US$
Million for Years 2011 through 2015 (includes corresponding
Graph/Chart) III-21

Table 30: Japanese Historic Review for Pain Management by
Product Segment - Pain Management Pharmaceuticals, Pain
Management Devices and Pain Management Services Markets
Independently Analyzed with Annual Revenue Figures in US$
Million for Years 1991 through 2000 (includes corresponding
Graph/Chart) III-22

Table 31: Japanese 20-Year Perspective for Pain Management
by Product Segment - Percentage Breakdown of Dollar Revenue
for Pain Management Pharmaceuticals, Pain Management Devices
and Pain Management Services Markets for 1991, 1997, 2007 &
2010 (includes corresponding Graph/Chart) III-22

4. Europe III-23
A.Market Analysis III-23
Current & Future Analysis III-23
Strategic Corporate Developments III-23
B.Market Analytics III-24
Table 32: European Recent Past, Current & Future Analysis
for Pain Management by Geographic Region - France, Germany,
UK, Italy, Spain, Russia & Rest of Europe Markets
Independently Analyzed with Annual Revenue Figures in US$
Million for Years 2001 through 2010 (includes corresponding
Graph/Chart) III-24

Table 33: European Long-Term Projections for Pain Management
by Geographic Region - France, Germany, UK, Italy, Spain,
Russia & Rest of Europe Markets Independently Analyzed with
Annual Revenue Figures in US$ Million for Years 2011 through
2015 (includes corresponding Graph/Chart) III-25

Table 34: European Recent Past, Current & Future Analysis
for Pain Management by Product Segment - Pain Management
Pharmaceuticals, Pain Management Devices and Pain Management
Services Markets Independently Analyzed with Annual Revenue
Figures in US$ Million for Years 2001 through 2010 (includes
corresponding Graph/Chart) III-25

Table 35: European Long-Term Projections s for Pain
Management by Product Segment - Pain Management
Pharmaceuticals, Pain Management Devices and Pain Management
Services Markets Independently Analyzed with Annual Revenue
Figures in US$ Million for Years 2011 through 2015 (includes
corresponding Graph/Chart) III-26

Table 36: European Historic Review for Pain Management by
Geographic Region - France, Germany, UK, Italy, Spain,
Russia & Rest of Europe Markets Independently Analyzed with
Annual Revenue Figures in US$ Million for Years 1991 through
2000 (includes corresponding Graph/Chart) III-26

Table 37: European Historic Review for Pain Management by
Product Segment - Pain Management Pharmaceuticals, Pain
Management Devices And Pain Management Services Markets
Independently Analyzed With Annual Revenue Figures in US$
Million For Years 1991 through 2000 (includes corresponding
Graph/Chart) III-27

Table 38: European 20-Year Perspective for Pain Management
by Geographic Region - Percentage Breakdown of Dollar
Revenue for France, Germany, UK, Italy, Spain, Russia & Rest
of Europe Markets for Years 1991, 1997, 2007 & 2010
(includes corresponding Graph/Chart) III-27

Table 39: European 20-Year Perspective for Pain Management
by Product Segment - Percentage Breakdown of Dollar Revenue
for Pain Management Pharmaceuticals, Pain Management Devices
and Pain Management Services Markets for 1991, 1997, 2007 &
2010 (includes corresponding Graph/Chart) III-28

4a. France III-29
A.Market Analysis III-29
Strategic Corporate Developments III-29
Key Player Review III-29
Sanofi Aventis III-29
B.Market Analytics III-30
Table 40: French Recent Past, Current & Future Analysis for
Pain Management by Product Segment - Pain Management
Pharmaceuticals, Pain Management Devices and Pain Management
Services Markets Independently Analyzed with Annual Revenue
Figures in US$ Million for Years 2001 through 2010 (includes
corresponding Graph/Chart) III-30

Table 41: French Long-Term Projections for Pain Management
by Product Segment - Pain Management Pharmaceuticals, Pain
Management Devices and Pain Management Services Markets
Independently Analyzed with Annual Revenue Figures in US$
Million for Years 2011 through 2015 (includes corresponding
Graph/Chart) III-30

Table 42: French Historic Review for Pain Management by
Product Segment - Pain Management Pharmaceuticals, Pain
Management Devices and Pain Management Services Markets
Independently Analyzed with Annual Revenue Figures in US$
Million for Years 1991 through 2000 (includes corresponding
Graph/Chart) III-31

Table 43: French 20-Year Perspective for Pain Management by
Product Segment - Percentage Breakdown of Dollar Revenue for
Pain Management Pharmaceuticals, Pain Management Devices and
Pain Management Services Markets for 1991, 1997, 2007 & 2010
(includes corresponding Graph/Chart) III-31

4b. Germany III-32
Market Analysis III-32
Table 44: German Recent Past, Current & Future Analysis for
Pain Management by Product Segment - Pain Management
Pharmaceuticals, Pain Management Devices and Pain Management
Services Markets Independently Analyzed with Annual Revenue
Figures in US$ Million for Years 2001 through 2010 (includes
corresponding Graph/Chart) III-32

Table 45: German Long-Term Projections for Pain Management
by Product Segment -Pain Management Pharmaceuticals, Pain
Management Devices and Pain Management Services Markets
Independently Analyzed with Annual Revenue Figures in US$
Million for Years 2011 through 2015 (includes corresponding
Graph/Chart) III-33

Table 46: German Historic Review for Pain Management by
Product Segment - Pain Management Pharmaceuticals, Pain
Management Devices and Pain Management Services Markets
Independently Analyzed with Annual Revenue Figures in US$
Million for Years 1991 through 2000 (includes corresponding
Graph/Chart) III-33

Table 47: German 20-Year Perspective for Pain Management by
Product Segment - Percentage Breakdown of Dollar Revenue for
Pain Management Pharmaceuticals, Pain Management Devices and
Pain Management Services Markets for 1991, 1997, 2007 & 2010
(includes corresponding Graph/Chart) III-34

4c. United Kingdom III-35
A.Market Analysis III-35
UK Pain Statistics III-35
Key Player Review III-35
Glaxo Smithkline Plc III-35
AstraZeneca Plc III-36
B.Market Analytics III-36
Table 48: UK Recent Past, Current & Future Analysis for Pain
Management by Product Segment -Pain Management
Pharmaceuticals, Pain Management Devices and Pain Management
Services Markets Independently Analyzed with Annual Revenue
Figures in US$ Million for Years 2001 through 2010 (includes
corresponding Graph/Chart) III-36

Table 49: UK Long-Term Projections for Pain Management by
Product Segment -Pain Management Pharmaceuticals, Pain
Management Devices and Pain Management Services Markets
Independently Analyzed with Annual Revenue Figures in US$
Million for Years 2011 through 2015 (includes corresponding
Graph/Chart) III-37

Table 50: UK Historic Review for Pain Management by Product
Segment - Pain Management Pharmaceuticals, Pain Management
Devices and Pain Management Services Markets Independently
Analyzed with Annual Revenue Figures in US$ Million for
Years 1991 through 2000 (includes corresponding Graph/Chart) III-37

Table 51: UK 20-Year Perspective for Pain Management by
Product Segment - Percentage Breakdown of Dollar Revenue for
Pain Management Pharmaceuticals, Pain Management Devices and
Pain Management Services Markets for 1991, 1997, 2007 & 2010
(includes corresponding Graph/Chart) III-38

4d. Italy III-39
Market Analysis III-39
Table 52: Italian Recent Past, Current & Future Analysis for
Pain Management by Product Segment - Pain Management
Pharmaceuticals, Pain Management Devices and Pain Management
Services Markets Independently Analyzed with Annual Revenue
Figures in US$ Million for Years 2001 through 2010 (includes
corresponding Graph/Chart) III-39

Table 53: Italian Long-Term Projections for Pain Management
by Product Segment -Pain Management Pharmaceuticals, Pain
Management Devices and Pain Management Services Markets
Independently Analyzed with Annual Revenue Figures in US$
Million for Years 2011 through 2015 (includes corresponding
Graph/Chart) III-40

Table 54: Italian Historic Review for Pain Management by
Product Segment - Pain Management Pharmaceuticals, Pain
Management Devices and Pain Management Services Markets
Independently Analyzed with Annual Revenue Figures in US$
Million for Years 1991 through 2000 (includes corresponding
Graph/Chart) III-40

Table 55: Italian 20-Year Perspective for Pain Management by
Product Segment - Percentage Breakdown of Dollar Revenue for
Pain Management Pharmaceuticals, Pain Management Devices and
Pain Management Services Markets for 1991, 1997, 2007 & 2010
(includes corresponding Graph/Chart) III-41

4e. Spain III-42
Market Analysis III-42
Table 56: Spanish Recent Past, Current & Future Analysis for
Pain Management by Product Segment - Pain Management
Pharmaceuticals, Pain Management Devices and Pain Management
Services Markets Independently Analyzed with Annual Revenue
Figures in US$ Million for Years 2001 through 2010 (includes
corresponding Graph/Chart) III-42

Table 57: Spanish Long-Term Projections for Pain Management
by Product Segment -Pain Management Pharmaceuticals, Pain
Management Devices and Pain Management Services Markets
Independently Analyzed with Annual Revenue Figures in US$
Million for Years 2011 through 2015 (includes corresponding
Graph/Chart) III-43

Table 58: Spanish Historic Review for Pain Management by
Product Segment - Pain Management Pharmaceuticals, Pain
Management Devices and Pain Management Services Markets
Independently Analyzed with Annual Revenue Figures in US$
Million for Years 1991 through 2000 (includes corresponding
Graph/Chart) III-43

Table 59: Spanish 20-Year Perspective for Pain Management by
Product Segment - Percentage Breakdown of Dollar Revenue for
Pain Management Pharmaceuticals, Pain Management Devices and
Pain Management Services Markets for 1991, 1997, 2007 & 2010
(includes corresponding Graph/Chart) III-44

4f. Russia III-45
Market Analysis III-45
Table 60: Russian Recent Past, Current & Future Analysis for
Pain Management by Product Segment - Pain Management
Pharmaceuticals, Pain Management Devices and Pain Management
Services Markets Independently Analyzed with Annual Revenue
Figures in US$ Million for Years 2001 through 2010 (includes
corresponding Graph/Chart) III-45

Table 61: Russian Long-Term Projections for Pain Management
by Product Segment -Pain Management Pharmaceuticals, Pain
Management Devices and Pain Management Services Markets
Independently Analyzed with Annual Revenue Figures in US$
Million for Years 2011 through 2015 (includes corresponding
Graph/Chart) III-46

Table 62: Russian Historic Review for Pain Management by
Product Segment - Pain Management Pharmaceuticals, Pain
Management Devices and Pain Management Services Markets
Independently Analyzed with Annual Revenue Figures in US$
Million for Years 1991 through 2000 (includes corresponding
Graph/Chart) III-46

Table 63: Russian 20-Year Perspective for Pain Management by
Product Segment - Percentage Breakdown of Dollar Revenue for
Pain Management Pharmaceuticals, Pain Management Devices and
Pain Management Services Markets for 1991, 1997, 2007 & 2010
(includes corresponding Graph/Chart) III-47

4g. Rest of Europe III-48
A.Market Analysis III-48
Strategic Corporate Development III-48
B.Market Analytics III-49
Table 64: Rest of Europe Recent Past, Current & Future
Analysis for Pain Management by Product Segment -Pain
Management Pharmaceuticals, Pain Management Devices and Pain
Management Services Markets Independently Analyzed with
Annual Revenue Figures in US$ Million for Years 2001 through
2010 (includes corresponding Graph/Chart) III-49

Table 65: Rest of Europe Long-Term Projections for Pain
Management by Product Segment -Pain Management
Pharmaceuticals, Pain Management Devices and Pain Management
Services Markets Independently Analyzed with Annual Revenue
Figures in US$ Million for Years 2011 through 2015 (includes
corresponding Graph/Chart) III-50

Table 66: Rest of Europe Historic Review for Pain Management
by Product Segment - Pain Management Pharmaceuticals, Pain
Management Devices and Pain Management Services Markets
Independently Analyzed with Annual Revenue Figures in US$
Million for Years 1991 through 2000 (includes corresponding
Graph/Chart) III-50

Table 67: Rest of Europe 20-Year Perspective for Pain
Management by Product Segment - Percentage Breakdown of
Dollar Revenue for Pain Management Pharmaceuticals, Pain
Management Devices and Pain Management Services Markets for
1991, 1997, 2007 & 2010 (includes corresponding Graph/Chart) III-51

5. Asia-Pacific III-52
A.Market Analysis III-52
Current & Future Analysis III-52
India III-52
Strategic Corporate Developments III-52
B.Market Analytics III-53
Table 68: Asia-Pacific Recent Past, Current & Future
Analysis for Pain Management by Product Segment -Pain
Management Pharmaceuticals, Pain Management Devices and Pain
Management Services Markets Independently Analyzed with
Annual Revenue Figures in US$ Million for Years 2001 through
2010 (includes corresponding Graph/Chart) III-53

Table 69: Asia-Pacific Long-Term Projections for Pain
Management by Product Segment -Pain Management
Pharmaceuticals, Pain Management Devices and Pain Management
Services Markets Independently Analyzed with Annual Revenue
Figures in US$ Million for Years 2011 through 2015 (includes
corresponding Graph/Chart) III-54

Table 70: Asia-Pacific Historic Review for Pain Management
by Product Segment - Pain Management Pharmaceuticals, Pain
Management Devices and Pain Management Services Markets
Independently Analyzed with Annual Revenue Figures in US$
Million for Years 1991 through 2000 (includes corresponding
Graph/Chart) III-54

Table 71: Asia-Pacific 20-Year Perspective for Pain
Management by Product Segment - Percentage Breakdown of
Dollar Revenue for Pain Management Pharmaceuticals, Pain
Management Devices and Pain Management Services Markets for
1991, 1997, 2007 & 2010 (includes corresponding Graph/Chart) III-55

6. Latin America III-56
Market Analysis III-56
Table 72: Latin America Recent Past, Current & Future
Analysis for Pain Management by Product Segment -Pain
Management Pharmaceuticals, Pain Management Devices and Pain
Management Services Markets Independently Analyzed with
Annual Revenue Figures in US$ Million for Years 2001 through
2010 (includes corresponding Graph/Chart) III-56

Table 73: Latin America Long-Term Projections for Pain
Management by Product Segment -Pain Management
Pharmaceuticals, Pain Management Devices and Pain Management
Services Markets Independently Analyzed with Annual Revenue
Figures in US$ Million for Years 2011 through 2015 (includes
corresponding Graph/Chart) III-57

Table 74: Latin America Historic Review for Pain Management
by Product Segment - Pain Management Pharmaceuticals, Pain
Management Devices and Pain Management Services Markets
Independently Analyzed with Annual Revenue Figures in US$
Million for Years 1991 through 2000 (includes corresponding
Graph/Chart) III-57

Table 75: Latin America 20-Year Perspective for Pain
Management by Product Segment - Percentage Breakdown of
Dollar Revenue for Pain Management Pharmaceuticals, Pain
Management Devices and Pain Management Services Markets for
1991, 1997, 2007 & 2010 (includes corresponding Graph/Chart) III-58

7. Rest of World III-59
Market Analysis III-59
Table 76: Rest of World Recent Past, Current & Future
Analysis for Pain Management by Product Segment - Pain
Management Pharmaceuticals, Pain Management Devices and Pain
Management Services Markets Independently Analyzed with
Annual Revenue Figures in US$ Million for Years 2001 through
2010 (includes corresponding Graph/Chart) III-59

Table 77: Rest of World Long-Term Projections s for Pain
Management by Product Segment - Pain Management
Pharmaceuticals, Pain Management Devices and Pain Management
Services Markets Independently Analyzed with Annual Revenue
Figures in US$ Million for Years 2011 through 2015 (includes
corresponding Graph/Chart) III-60

Table 78: Rest of World Historic Review for Pain Management
by Product Segment - Pain Management Pharmaceuticals, Pain
Management Devices and Pain Management Services Markets
Independently Analyzed with Annual Revenue Figures in US$
Million for Years 1991 through 2000 (includes corresponding
Graph/Chart) III-60

Table 79: Rest of World 20-Year Perspective for Pain
Management by Product Segment - Percentage Breakdown of
Dollar Revenue for Pain Management Pharmaceuticals, Pain
Management Devices and Pain Management Services Markets for
1991, 1997, 2007 & 2010 (includes corresponding Graph/Chart) III-61


IV. COMPETITIVE LANDSCAPE