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Cancer Cachexia - Pipeline Review, H1 2016

  • February 2016
  • -
  • Global Markets Direct
  • -
  • 113 pages

Cancer Cachexia - Pipeline Review, H1 2016

Summary

Global Markets Direct’s, ‘Cancer Cachexia - Pipeline Review, H1 2016’, provides an overview of the Cancer Cachexia pipeline landscape.

The report provides comprehensive information on the therapeutics under development for Cancer Cachexia, complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. The report also covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases. Additionally, the report provides an overview of key players involved in therapeutic development for Cancer Cachexia and features dormant and discontinued projects.

Global Markets Direct’s report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct’s proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources. Drug profiles featured in the report undergoes periodic review following a stringent set of processes to ensure that all the profiles are updated with the latest set of information. Additionally, various dynamic tracking processes ensure that the most recent developments are captured on a real time basis.

The report helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage.

Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data.

Scope

- The report provides a snapshot of the global therapeutic landscape of Cancer Cachexia
- The report reviews pipeline therapeutics for Cancer Cachexia by companies and universities/research institutes based on information derived from company and industry-specific sources
- The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages
- The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
- The report reviews key players involved Cancer Cachexia therapeutics and enlists all their major and minor projects
- The report assesses Cancer Cachexia therapeutics based on drug target, mechanism of action (MoA), route of administration (RoA) and molecule type
- The report summarizes all the dormant and discontinued pipeline projects
- The report reviews latest news related to pipeline therapeutics for Cancer Cachexia

Reasons to buy

- Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
- Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
- Identify and understand important and diverse types of therapeutics under development for Cancer Cachexia
- Identify potential new clients or partners in the target demographic
- Develop strategic initiatives by understanding the focus areas of leading companies
- Plan mergers and acquisitions effectively by identifying key players and it’s most promising pipeline therapeutics
- Devise corrective measures for pipeline projects by understanding Cancer Cachexia pipeline depth and focus of Indication therapeutics
- Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope
- Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline

Table Of Contents

Cancer Cachexia - Pipeline Review, H1 2016
Table of Contents
Table of Contents 2
List of Tables 6
List of Figures 7
Introduction 8
Global Markets Direct Report Coverage 8
Cancer Cachexia Overview 9
Therapeutics Development 10
Pipeline Products for Cancer Cachexia - Overview 10
Pipeline Products for Cancer Cachexia - Comparative Analysis 11
Cancer Cachexia - Therapeutics under Development by Companies 12
Cancer Cachexia - Therapeutics under Investigation by Universities/Institutes 14
Cancer Cachexia - Pipeline Products Glance 15
Late Stage Products 15
Clinical Stage Products 16
Early Stage Products 17
Cancer Cachexia - Products under Development by Companies 18
Cancer Cachexia - Products under Investigation by Universities/Institutes 20
Cancer Cachexia - Companies Involved in Therapeutics Development 21
Acacia Pharma Limited 21
Aeterna Zentaris Inc. 22
Aphios Corporation 23
Atara Biotherapeutics, Inc. 24
Eli Lilly and Company 25
Helsinn Healthcare S.A. 26
Incyte Corporation 27
Novartis AG 28
Obexia AG 29
PsiOxus Therapeutics Limited 30
RaQualia Pharma Inc. 31
Viking Therapeutics, Inc. 32
Cancer Cachexia - Therapeutics Assessment 33
Assessment by Monotherapy Products 33
Assessment by Combination Products 34
Assessment by Target 35
Assessment by Mechanism of Action 37
Assessment by Route of Administration 39
Assessment by Molecule Type 41
Drug Profiles 43
(formoterol fumarate + megestrol acetate) - Drug Profile 43
Product Description 43
Mechanism of Action 43
RandD Progress 43
anamorelin hydrochloride - Drug Profile 44
Product Description 44
Mechanism of Action 44
RandD Progress 44
Antibody to Inhibit Parathyroid Hormone Related Protein for Cancer Cachexia - Drug Profile 46
Product Description 46
Mechanism of Action 46
RandD Progress 46
Aptamer to Activate Calcineurin A for Genetic Disorders and Musculoskeletal Disorders - Drug Profile 47
Product Description 47
Mechanism of Action 47
RandD Progress 47
ATA-842 - Drug Profile 48
Product Description 48
Mechanism of Action 48
RandD Progress 48
AUSRM-057 - Drug Profile 49
Product Description 49
Mechanism of Action 49
RandD Progress 49
bimagrumab - Drug Profile 50
Product Description 50
Mechanism of Action 50
RandD Progress 50
C-1889 - Drug Profile 52
Product Description 52
Mechanism of Action 52
RandD Progress 52
DLN-101 - Drug Profile 54
Product Description 54
Mechanism of Action 54
RandD Progress 54
dronabinol - Drug Profile 55
Product Description 55
Mechanism of Action 55
RandD Progress 55
espindolol - Drug Profile 56
Product Description 56
Mechanism of Action 56
RandD Progress 56
EXT-400 - Drug Profile 58
Product Description 58
Mechanism of Action 58
RandD Progress 58
Foxo1-nRNA - Drug Profile 59
Product Description 59
Mechanism of Action 59
RandD Progress 59
HM-03 - Drug Profile 60
Product Description 60
Mechanism of Action 60
RandD Progress 60
landogrozumab - Drug Profile 61
Product Description 61
Mechanism of Action 61
RandD Progress 61
macimorelin acetate - Drug Profile 62
Product Description 62
Mechanism of Action 62
RandD Progress 62
Monoclonal Antibody to Antagonize TWEAK Receptor for Cachexia - Drug Profile 64
Product Description 64
Mechanism of Action 64
RandD Progress 64
Monoclonal Antibody to Antagonize TWEAK Receptor for Cachexia and Cancer Cachexia - Drug Profile 65
Product Description 65
Mechanism of Action 65
RandD Progress 65
NBD Peptide - Drug Profile 66
Product Description 66
Mechanism of Action 66
RandD Progress 66
OBX-1201 - Drug Profile 68
Product Description 68
Mechanism of Action 68
RandD Progress 68
RQ-00433412 - Drug Profile 69
Product Description 69
Mechanism of Action 69
RandD Progress 69
ruxolitinib phosphate - Drug Profile 70
Product Description 70
Mechanism of Action 70
RandD Progress 70
Small Molecule to Inhibit ATGL for Cancer Cachexia and Type 2 Diabetes - Drug Profile 75
Product Description 75
Mechanism of Action 75
RandD Progress 75
Synthetic Peptide to Inhibit Melanocortin Receptor for Cancer Cachexia - Drug Profile 76
Product Description 76
Mechanism of Action 76
RandD Progress 76
Synthetic Peptides for Cancer Cachexia - Drug Profile 77
Product Description 77
Mechanism of Action 77
RandD Progress 77
tertomotide - Drug Profile 78
Product Description 78
Mechanism of Action 78
RandD Progress 78
VK-5211 - Drug Profile 80
Product Description 80
Mechanism of Action 80
RandD Progress 80
Cancer Cachexia - Recent Pipeline Updates 82
Cancer Cachexia - Dormant Projects 101
Cancer Cachexia - Discontinued Products 103
Cancer Cachexia - Product Development Milestones 104
Featured News and Press Releases 104
Oct 30, 2014: New Data on Fatigue from ROMANA 1, a Pivotal Phase III Study of Anamorelin in Advanced NSCLC Patients with Cachexia Presented at 2014 Chicago Multidisciplinary Symposium in Thoracic Oncology 104
Mar 04, 2013: PsiOxus Therapeutics Completes Patient Enrollment For Phase II Wasting Disease Therapeutic MT-102 105
Aug 28, 2012: Aeterna Zentaris Recruits First Patient For Phase IIA Trial In Cancer Cachexia With AEZS-130 105
Mar 08, 2012: Michael E. DeBakey Veterans Affairs Medical Center Initiates Phase IIa Trial In Cancer Cachexia With Aeterna Zentaris's Ghrelin Agonist, AEZS-130 106
Dec 08, 2011: PsiOxus Therapeutics To Present Data On MT-102 At Cachexia Conference 107
Dec 06, 2011: Acacia Pharma Announces Positive Results From Phase IIa Cancer Cachexia Study 108
Nov 28, 2011: FDA Grants IND To Investigator At Baylor College Of Medicine For Phase IIa Trial With AEZS-130 In Cancer Cachexia 108
Mar 17, 2011: PsiOxus Therapeutics Initiates Phase II Clinical Study Of Wasting Disease Therapeutic MT-102 109
Dec 16, 2010: Myotec Therapeutics Completes Merger With Hybrid BioSystems To Form PsiOxus Therapeutics 110
Apr 26, 2007: Sapphire Therapeutics, Inc. to Present Results From Anamorelin Phase II Cachexia/Anorexia Studies at American Society of Clinical Oncology and Endocrine Society Annual Meetings in June 111
Appendix 112
Methodology 112
Coverage 112
Secondary Research 112
Primary Research 112
Expert Panel Validation 112
Contact Us 112
Disclaimer 113

List of Tables
Number of Products under Development for Cancer Cachexia, H1 2016 10
Number of Products under Development for Cancer Cachexia - Comparative Analysis, H1 2016 11
Number of Products under Development by Companies, H1 2016 13
Number of Products under Investigation by Universities/Institutes, H1 2016 14
Comparative Analysis by Late Stage Development, H1 2016 15
Comparative Analysis by Clinical Stage Development, H1 2016 16
Comparative Analysis by Early Stage Development, H1 2016 17
Products under Development by Companies, H1 2016 18
Products under Development by Companies, H1 2016 (Contd..1) 19
Products under Investigation by Universities/Institutes, H1 2016 20
Cancer Cachexia - Pipeline by Acacia Pharma Limited, H1 2016 21
Cancer Cachexia - Pipeline by Aeterna Zentaris Inc., H1 2016 22
Cancer Cachexia - Pipeline by Aphios Corporation, H1 2016 23
Cancer Cachexia - Pipeline by Atara Biotherapeutics, Inc., H1 2016 24
Cancer Cachexia - Pipeline by Eli Lilly and Company, H1 2016 25
Cancer Cachexia - Pipeline by Helsinn Healthcare S.A., H1 2016 26
Cancer Cachexia - Pipeline by Incyte Corporation, H1 2016 27
Cancer Cachexia - Pipeline by Novartis AG, H1 2016 28
Cancer Cachexia - Pipeline by Obexia AG, H1 2016 29
Cancer Cachexia - Pipeline by PsiOxus Therapeutics Limited, H1 2016 30
Cancer Cachexia - Pipeline by RaQualia Pharma Inc., H1 2016 31
Cancer Cachexia - Pipeline by Viking Therapeutics, Inc., H1 2016 32
Assessment by Monotherapy Products, H1 2016 33
Assessment by Combination Products, H1 2016 34
Number of Products by Stage and Target, H1 2016 36
Number of Products by Stage and Mechanism of Action, H1 2016 38
Number of Products by Stage and Route of Administration, H1 2016 40
Number of Products by Stage and Molecule Type, H1 2016 42
Cancer Cachexia Therapeutics - Recent Pipeline Updates, H1 2016 82
Cancer Cachexia - Dormant Projects, H1 2016 101
Cancer Cachexia - Dormant Projects (Contd..1), H1 2016 102
Cancer Cachexia - Discontinued Products, H1 2016 103

List of Figures
Number of Products under Development for Cancer Cachexia, H1 2016 10
Number of Products under Development for Cancer Cachexia - Comparative Analysis, H1 2016 11
Number of Products under Development by Companies, H1 2016 12
Comparative Analysis by Late Stage Development, H1 2016 15
Comparative Analysis by Clinical Stage Development, H1 2016 16
Comparative Analysis by Early Stage Products, H1 2016 17
Assessment by Monotherapy Products, H1 2016 33
Number of Products by Top 10 Targets, H1 2016 35
Number of Products by Stage and Top 10 Targets, H1 2016 35
Number of Products by Top 10 Mechanism of Actions, H1 2016 37
Number of Products by Stage and Top 10 Mechanism of Actions, H1 2016 37
Number of Products by Routes of Administration, H1 2016 39
Number of Products by Stage and Routes of Administration, H1 2016 39
Number of Products by Molecule Types, H1 2016 41
Number of Products by Stage and Molecule Types, H1 2016 41

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