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Global Flow Cytometry Market

  • March 2016
  • -
  • TriMark Publications
  • -
  • 166 pages

Flow cytometry is a laboratory analytical technique that can rapidly measure multiple parameters of individual cells or particles as they pass through a beam of light, typically a laser. The global flow cytometry market remains one of the fastest-growing segments of life sciences and clinical diagnostics markets. In the current life sciences research, pharmaceutical drug discovery and development, and clinical diagnostics markets, flow cytometry offers some of the brightest promise for growth and innovation. The purpose of this TriMark Publications report is to provide a detailed analysis of the global flow cytometry market, including size, growth, technology platforms, applications, new instrumentation, industry trends and the internal structure of the sector. The study covers highly attractive growth areas such as stem cell research, biomarkers and companion diagnostics, CD4 testing, high throughput screening and immunology and vaccine development. It also analyzes almost all of the companies known to be marketing, manufacturing or developing flow cytometry products in the U.S. and worldwide. Additionally, this review provides detailed tables, charts and figures with past and projected sales data by geographic region for North America, Europe, Asia-Pacific and the emerging BRIC (Brazil, Russia, India and China) markets.

Table Of Contents

Global Flow Cytometry Market










TABLE OF CONTENTS



1. Overview 8

1.1 Statement of Report 8

1.2 About This Report 9

1.3 Scope of the Report 10

1.4 Methodology 10



2. Executive Summary 13

2.1 Global Flow Cytometry Market Projected to Reach $5.9 Billion by 2020 13

2.2 Three Major Companies Command Over Half the Global Flow Cytometry Market 13

2.3 Reagents and Consumables are the Fastest Growing Product Group 13

2.4 Flow Cytometry will Advance Research and Development of New Cellular
Therapies, Biologics and Vaccines 14

2.5 There is an Urgent Need for Point of Care Flow Cytometry in Resource Limited
Countries 14



3. Market Environment 16

3.1 Global Economic Uncertainty 16

3.2 Lower Healthcare Utilization 16

3.3 Reduced Government Funding for Life Science Research 16

3.4 Consolidation of the Pharmaceutical Industry and Outsourcing to CROs 16

3.5 Global Aid to Resource Limited Countries 17



4. Flow Cytometry is a Dynamic Market 18

4.1 Market Leaders Strengthen their Dominant Position 18

4.2 Trends in the Global Flow Cytometry Market 19

4.2.1 More Lasers, More Fluorescent Dyes, More Data 19

4.2.2 Personal Flow Cytometers Moving Flow Cytometry Out of Core Laboratories 19

4.2.3 High Throughput Screening and Clinical Diagnostic Flow Cytometry Driving
Workflow Automation 20

4.2.4 Portable POC Flow Cytometry Bringing CD4 Testing to Clinics and Remote
Areas in Resource Limited Countries 20

4.2.5 Cell Sorters are Scaled Up for Clinical Scale Cell Sorting 20

4.3 Growth Opportunities in the Global Flow Cytometry Market 20

4.3.1 Microfluidics, Next Generation Cell Analysis and Sorting 20

4.3.2 Integrating Complementary Technologies Enable New Applications 21

4.3.3 A Gap and Challenge for Computational Data Analysis 21

4.3.4 High Growth Applications in Applied Markets Require Specialty Flow
Cytometers 22

4.4 Strategic Considerations 22

4.4.1 The Flow Cytometry Market is Highly Competitive 22

4.4.2 County to Country Dynamics Impact International Operations 23

4.4.3 Governments are the Largest Funders of Life Science Research 23

4.4.4 Reimbursement for Clinical Diagnostics Impacts Acceptance of New Tests 23



5. The Global Flow Cytometry Market 25

5.1 Projected Global Flow Cytometry Market Revenue Through 2020 25

5.2 Market Drivers 25

5.3 Market Restrictors 26



6. Flow Cytometry Users 28

6.1 Pharmaceutical, Biotechnology, CROs 28

6.2 Clinical Diagnostic 28

6.3 Academic, Government, Private Foundations 29

6.4 Applied Science 29



7. Flow Cytometry Market Competitive Landscape 30

7.1 Competitors and Market Share 30

7.2 Key Players 31

7.2.1 BD Biosciences 31

7.2.2 Beckman Coulter 36

7.2.3 Thermo Fisher Scientific 41

7.2.4 Luminex Corporation 45

7.2.5 MilliporeSigma 49

7.2.6 Sysmex 53

7.2.7 Miltenyi Biotec 56



8. Global Flow Cytometry Market Analysis by Product 59

8.1 Projected Flow Cytometry Revenue by Product 59

8.2 Projected Flow Cytometry Instrument Revenue 63

8.2.1 Competitive Features of Flow Cytometry Instruments 64

8.2.1.1 High Performance Multicolor Flow Cytometers 64

8.2.1.2 Compact Flow Cytometers 67

8.2.1.3 Handheld Flow Cytometers 68

8.2.1.4 Cell Sorters 69

8.2.1.5 Flow Cytometry Imaging Systems 72

8.2.1.6 Mass Cytometry Systems 72

8.2.1.7 Multiplex Bead Flow Cytometry Systems 73

8.2.1.8 Flow Cytometry End-to-End Workflow Solutions 74

8.2.1.9 Considerations when Purchasing a Flow Cytometry Instrument 75

8.3 Projected Flow Cytometry Reagents and Consumables Revenue 76

8.3.1 Selecting Flow Cytometry Reagents 76

8.3.2 Leading Flow Cytometry Reagent Suppliers 78

8.4 Flow Cytometry Software and Bioinformatics Developers 79



9. Global Flow Cytometry Market Analysis by Region 82

9.1 Projected Flow Cytometry Market Revenue by Region 82

9.2 North America Flow Cytometry Market 84

9.2.1 North American Flow Cytometry Market Projected Revenue 84

9.2.2 Research Segment 85

9.2.3 Pharmaceutical and Biotechnology Segment 86

9.2.4 Clinical Diagnostics Segment 87

9.3 Western Europe Flow Cytometry Market 88

9.3.1 Western Europe Flow Cytometry Market Projected Revenue 88

9.3.2 Research Segment 89

9.3.3 Pharmaceutical and Biotechnology Segment 90

9.3.4 Clinical Diagnostics Segment 90

9.4 Asia-Pacific Flow Cytometry Market 91

9.4.1 Asia-Pacific Flow Cytometry Market Projected Revenue 91

9.4.2 Research Segment 91

9.4.3 Pharmaceutical and Biotechnology Segment 91

9.4.4 Clinical Diagnostics Segment 92

9.5 Emerging High Growth Markets 92

9.5.1 Emerging High Growth Markets Projected Revenue 92

9.5.2 China Flow Cytometry Market 95

9.5.2.1 China Market Projected Revenue 95

9.5.2.2 Research Segment 95

9.5.2.3 Pharmaceutical and Biotechnology Segment 96

9.5.2.4 Clinical Diagnostics Segment 96

9.5.3 India Flow Cytometry Market 97

9.5.3.1 India Market Projected Revenue 97

9.5.3.2 Research Segment 97

9.5.3.3 Pharmaceutical and Biotechnology Segment 98

9.5.3.4 Clinical Diagnostics Segment 98

9.5.4 Brazil Flow Cytometry Market 99

9.5.4.1 Brazil Market Projected Revenue 99

9.5.4.2 Research Segment 99

9.5.4.3 Pharmaceutical and Biotechnology Segment 100

9.5.4.4 Clinical Diagnostics Segment 100

9.5.5 Russian Federation, Central and Eastern Europe Flow Cytometry Market 100



10. The POC Flow Cytometry Market in Resource Limited Countries 102

10.1 Global Response to AIDS Epidemic Rapidly Increasing Demand for CD4 Testing
102

10.2 Clinics in Rural Regions do not have CD4 Testing Capability 103

10.3 Tiered Laboratory System in Resource Limited Countries 104

10.4 The Flow Cytometry and POC Flow Cytometry Market Projected Revenue,
2015-2020 104

10.5 The Global Flow Cytometry and POC Flow Cytometry Market by Region 107

10.5.1 The Flow Cytometry and POC Flow Cytometry Market Revenue by Region 107

10.5.2 South Africa POC Flow Cytometry Market 109

10.5.3 Nigeria POC Flow Cytometry Market 109

10.5.4 India POC Flow Cytometry Market 110

10.5.5 China POC Flow Cytometry Market 110

12.5.6 Russian Federation, Eastern Europe and Central Asia POC Flow Cytometry
Market 111

10.5.7 Latin America POC Flow Cytometry Market 111

10.6 Competitors in the Flow Cytometry and POC Flow Market in Resource Limited
Countries 112

10.6.1 Competitor's Flow Cytometry Flow Cytometers and POC Flow Cytometry
Analyzers 113



11. Recent Industry Developments, 2014-2016 117



12. Flow Cytometry Applications 123

12.1 Research Applications 123

12.1.1 Cell Signaling 123

12.1.2 Cell Proliferation 123

12.1.3 Cell Viability 124

12.1.4 Apoptosis 124

12.1.5 Cell Cycle Analysis 124

12.1.6 Intracellular Ion Measurement 124

12.1.7 Single Cell Gene Expression Analysis 125

12.1.8 Immunology and Immunotherapy 125

12.1.9 Stem Cell Research 126

12.1.10 Microbiology 127

12.2 Clinical Diagnostics 128

12.2.1 Regulatory Control of Flow Cytometry Clinical Diagnostic Applications 128

12.2.2 CD4 Lymphocyte Count 128

12.2.3 Immunophenotyping Leukemias and Lymphomas 129

12.2.4 Minimum Residual Disease 129

12.2.5 Anti-Neutrophil Antibody Detection in Auto-Immune and Immunodeficiency
Disease 129

12.2.6 Platelet-Associated Immunoglobulin Assays 129

12.2.7 Reticulocyte Count 130

12.2.8 HLA Crossmatching and Cell Analysis for Stem Cell and Organ
Transplantation 130

12.2.9 Paroxysmal Nocturnal Hemoglobinuria 130

12.2.10 Clinical Microbiology 131

12.3 Pharmaceutical and Biopharmaceutical Drug Discovery and Development 131

12.3.1 Drug Discovery and High Throughput Flow Cytometry 131

12.3.2 Preclinical Toxicology and Safety 132

12.3.3 Biomarkers and Drug Development 132

12.3.4 GMP Manufacture of Biologicals 133

12.3.5 Vaccine Development 133

12.4 Global Health 134

12.4.1 HIV/AIDS, Malaria, Tuberculosis 134

12.4.2 Tropical Medicine 134

12.5 Applied Sciences 135

12.5.1 Marine and Environmental Biology 136

12.5.2 Plant Biology 137

12.5.3 Veterinary Medicine 137

12.5.4 Food and Beverage Industry 138

12.5.5 BioDefense 138



13. Flow Cytometry Technology 139

13.1 Principle of Flow Cytometry 139

13.2 Fluidics 139

13.3 Optics 140

13.4 Electronics 141

13.5 Data Analysis 141

13.6 Cell Sorting 142

13.7 Labeling and Detection 142

13.8 Multiplex Bead Assays 143

13.9 Imaging Flow Cytometry 144

13.10 Mass Cytometry 145



14. New Flow Cytometry Technology 146

14.1 Microfluidics Flow Cytometry Technologies 146

14.2 Technologies for Rapid CD4 Testing 148



15. History of Flow Cytometry 150



16. Company Profiles 152

16.1 Abcam 152

16.2 Alere, Inc. 152

16.3 ALPCO Diagnostics 152

16.4 Apogee Flow Systems 152

16.5 Bangs Laboratories, a Division of Polysciences 153

16.6 Bay Bioscience 153

16.7 BD Biosciences (a Business Group within Becton Dickinson and Company (BD))
153

16.8 Beckman Coulter (Business within Danaher) 154

16.9 Bio-Rad Laboratories 155

16.10 BioVision 155

16.11 Cell Signaling Technology 156

16.12 Cira Discovery Sciences 156

16.13 Clarient Diagnostic Services, Inc. 156

16.14 Cytobank, Inc. 156

16.15 CytoBuoy, B.V 156

16.16 CytonomeST 156

16.17 Dako, an Agilent Technologies Company 157

16.18 DeNovo Software 157

16.19 Fluidigm Corporation 157

16.20 Handyem 158

16.21 IntelliCyt Corporation 158

16.22 Luminex Corporation 158

16.23 MBio Diagnostics 158

16.24 MilliporeSigma (Division of Merck KGaA Germany) 159

16.25 Miltenyi Biotec 160

16.26 Orflow Technologies 160

16.27 Sysmex 160

16.28 PointCare Technologies 161

16.29 Promega Corporation 161

16.30 Randamp;D Systems (Techne Corporation) 161

16.31 Santa Cruz Biotechnology 162

16.32 Soft Flow Hungary, Ltd. 162

16.33 Sony Biotechnology, Inc. 162

16.34 SouthernBiotech 162

16.35 Spherotech 162

16.36 Stratedigm 162

16.37 TaKaRa Clontech 162

16.38 Thermo Fisher Scientific 163

16.39 Tree Star 164

16.40 TTP LabTech 164

16.41 Union Biometrica 164

16.42 United States Biological Life Sciences 164

16.43 Verity Software House 165



17. Acronyms Used in This Report 166




INDEX OF FIGURES



Figure 6.1: Flow Cytometry Market by Laboratory Type, 2015 28

Figure 7.1: Flow Cytometry Competitors' Market Share, 2015 31

Figure 8.1: Flow Cytometry Market Distribution by Product Revenue, 2015 60

Figure 8.2: Flow Cytometry Market Distribution by Product Revenue, 2020 60

Figure 8.3: Projected Flow Cytometry Revenue Growth by Product (CAGR), 2014-2020
61

Figure 9.1: Global Flow Cytometry Market Revenue by Region, 2015 83

Figure 9.2: Projected Flow Cytometry Market Revenue by Region, 2014-2020 83

Figure 9.3: Flow Cytometry Projected Growth Rate by Region, CAGR 2014-2020 84

Figure 9.4: Western Europe Flow Cytometry Market by Country, 2015 89

Figure 9.5: Emerging High Growth Countries Projected Flow Cytometry Revenue by
Country, 2014-2020 94

Figure 9.6: Emerging Countries Flow Cytometry Revenue Share by Country, 2015 94

Figure 9.7: Emerging Countries Flow Cytometry Market Share by Country, 2020 95

Figure 10.1: CD4 Flow Cytometry Product Revenue Projection, 2014-2020 105

Figure 10.2: Flow Cytometry and POC Market Revenue by Region, 2015 108

Figure 10.3: Competitor's Share by Revenue, CD4 Flow Cytometry, 2015 112

Figure 10.4: Market Share, CD4 Counting Instruments in Middle- to Low-Income
Countries, 2013 112

Figure 13.1: Schematic of a Flow Cell 139

Figure 13.2: Schematic of a Flow Cytometer Optical Layout 140

Figure 13.3: Example of a Dot Plot of Lysed Whole Blood 141

Figure 13.4: Fluorescence Intensity Histogram 142

Figure 13.5: Principle of Multiplex Bead Assay 144




INDEX OF TABLES



Table 5.1: Flow Cytometry Projected Market Revenue, 2014-2020 25

Table 5.2: Flow Cytometry Market Drivers 26

Table 5.3: Flow Cytometry Market Restrictors 27

Table 7.1: BD Biosciences Flow Cytometry Product Line 33

Table 7.2: BD Biosciences Flow Cytometry Branded Reagents 35

Table 7.3: Beckman Coulter Flow Cytometry Product Line 38

Table 7.4: Beckman Coulter Branded Flow Cytometry Kits and Reagents 40

Table 7.5: Thermo Fisher Scientific Flow Cytometry Reagents 43

Table 7.6: Thermo Fisher Scientific Flow Cytometry Instruments 44

Table 7.7: Luminex Instruments for Multiple Assay Analysis 47

Table 7.8: Luminex Branded Multiplex Assays and Reagents 48

Table 7.9: MilliporeSigma Flow Cytometry Platforms 51

Table 7.10: MilliporeSigma Flow Cytometry Instruments, Kits, Reagents 52

Table 7.11: Sysmex Partec Flow Cytometry Product Line 55

Table 7.12: Sysmex Partec Flow Cytometry Instruments 55

Table 7.13: Sysmex Partec Reagents and Kits 55

Table 7.14: Miltenyi Biotec Cell Separation Products 58

Table 7.15: Miltenyi Biotec Flow Cytometry Product Line 58

Table 8.1: Flow Cytometry Projected Revenue by Product, 2014-2020 60

Table 8.2: Suppliers of Flow Cytometry Instruments, Reagents and Software 61

Table 8.3: Features: High Performance Multicolor Flow Cytometers 64

Table 8.4: Compact Flow Cytometers 67

Table 8.5: Handheld Flow Cytometers 69

Table 8.6: Features: Cell Sorters 69

Table 8.7: Mass Cytometry Technology Features 73

Table 8.8: Multiplex Instrument Features 73

Table 8.9: Considerations when Selecting a Flow Cytometer 76

Table 8.10: Manufacturers of Flow Cytometry Antibodies, Fluorophores, Kits,
Reagents, Sample Prep 78

Table 8.11: Flow Cytometry Software Developers 80

Table 9.1: Projected Flow Cytometry Market Revenue by Region, 2014-2020 83

Table 9.2: Flow Cytometry Projected Growth Rate by Region, CAGR 2014-2020 84

Table 9.3: North America Flow Cytometry Market Projected by Product, 2014-2020
84

Table 9.4: NIH Historical Appropriations, 2008-2016 85

Table 9.5: NIH Funding for Selected Disease Categories, 2016 85

Table 9.6: Flow Cytometry Systems in NIH Flow Cytometry Core Facilities 86

Table 9.7: CROs Specializing in Flow Cytometry Services 86

Table 9.8: Western Europe Flow Cytometry Market Projected by Product, 2014-2020
88

Table 9.9: Asia-Pacific Flow Cytometry Projected Market by Product, 20143-2020
91

Table 9.10: Emerging High Growth Countries Projected Flow Cytometry Revenue,
2014-2020 93

Table 10.1: Population of People Living with HIV/AIDS, 2014 102

Table 10.2: Projected Number of People Accessing ART Under the UNAIDS Fast-Track
Strategy,

2014-2020 103

Table 10.3: Optimal Features of a POC CD4 Test 103

Table 10.4: Flow Cytometry and POC Flow Cytometry Market Revenue, 2014-2020 105

Table 10.5: CD4 Flow Cytometry Product Revenue Projection, 2014-2020 106

Table 10.6: CD4 Flow Cytometry and POC Cytometry Market Drivers and Restrictors
107

Table 10.7: Global Distribution of People Living with HIV by Country 108

Table 10.8: Flow Cytometry and POC Flow Cytometry Market Revenue by Region, 2015
109

Table 10.9: CD4 Platforms for Resource Limited Countries 115

Table 12.1: Cell Types, Proteins and Microbes Detected by Flow Cytometry 123

Table 12.2: Flow Cytometry Applications in Stem Cell Research 126

Table 12.3: Microorganisms Detected by Flow Cytometry 127

Table 12.4: Flow Cytometry Clinical Diagnostic Applications 128

Table 12.5: Advantages of Flow Cytometry for High Throughput Screening 131

Table 12.6: Flow Cytometry Applications for Preclinical Toxicology and Safety
132

Table 12.7: NIH Definition of Biomarkers 133

Table 12.7: Neglected Tropical Diseases 135

Table 12.8: Flow Cytometry Products for Applied Markets 135

Table 13.1: Common Fluorophores Used in Flow Cytometry 143

Table 15.1: Differences between Hematology Analyzers and Flow Cytometers 150

Table 15.2: Flow Cytometry Timeline 151

Table 20.1: List of Acronyms Used in this Report 166






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