This report analyzes the worldwide markets for Chiral Technology in US$ Million by the following Chiral Technology Enabling Products: Intermediates, Analytical, and Others. The End Use markets also analyzed in the report include Pharmaceuticals, and Agrochemicals. The report provides separate comprehensive analytics for the US, Japan, Europe, and Rest of World. Annual estimates and forecasts are provided for the period 2009 through 2017. Also, a six-year historic analysis is provided for these markets. The report profiles 37 companies including many key and niche players such as Albemarle Corporation, BASF SE, Cambrex Corp., Chiral Quest Inc., Dalco ChromTech AB, Daicel Corporation., Chiral Technologies, Inc., Chiral Technologies Europe, DSM Pharmaceutical Products, Johnson Matthey PLC, Regis Technologies Inc., Shasun Pharmaceuticals Limited, Solvias, Sigma Aldrich Corp, and Suven Life Sciences Ltd. Market data and analytics are derived from primary and secondary research. Company profiles are primarily based upon search engine sources in the public domain.
Global Drug And Medication Industry
I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS
Study Reliability and Reporting Limitations I-1
Disclaimers I-2
Data Interpretation & Reporting Level I-3
Quantitative Techniques & Analytics I-3
Product Definitions and Scope of Study I-3
Chiral Technology Enabling Products I-4
Chiral Intermediates I-4
Analytical Products I-4
Other Products I-4
Chiral Technology End-Use Markets I-5
Pharmaceuticals I-5
Agrochemicals I-5
II. EXECUTIVE SUMMARY
1. MARKET OVERVIEW II-1
Bright Outlook for the Global Chiral Technology Market II-1
Table 1: World Chiral Technology Enabling Products Market by
Segment (2011): Percentage Share Breakdown by Value Sales for
Chiral Intermediates, Chiral Analytical Products, and Others
(includes corresponding Graph/Chart) II-1
Good Tidings for Chiral Technology II-1
Market Drivers II-3
Demand for Chiral-based Therapeutic Drugs Augments Growth II-3
New Legislations Push Chiral Technology Demand II-3
Key Market Trends II-3
Organizations Extend Approaches II-3
Companies’ Association with Universities II-3
Trends in Chiral Processes II-4
Increasing Reliance on Generic Approaches II-4
Predominant Use of Polysaccharides Derivatives as CSPs II-4
Automation: Introduction of Instruments Supporting Chiral
Processes, a Growing Trend II-4
2. CHIRAL TECHNOLOGY II-5
An Insight into Chiral Technology II-5
Techniques Used for Achieving Single-Isomers II-5
Table 2: World Chiral Technology Market (2011): Percentage
Breakdown of Revenues by Techniques- Traditional Methods,
Asymmetric Methods, and Biological Methods (includes
corresponding Graph/Chart) II-6
Importance and Advancements II-6
3. CHIRAL TECHNOLOGY - AN OVERVIEW II-7
Definitions II-7
Chiral Technology Enabling Products II-7
Chiral Intermediates II-7
Analytical Products II-7
Other Products II-7
Chiral Technology End-Use Markets II-8
Pharmaceuticals II-8
Agrochemicals II-8
Description II-8
Functioning of Chiral Molecules II-9
Chiral Preparation Process II-9
Traditional Methods II-9
Biological Methods II-10
Asymmetric Methods II-10
Chiral Separation II-11
Factors Influencing the Efficacy of Chiral Separations II-11
Recent Approaches in Chiral Separations II-11
Extensive Use of Supercritical Fluid Chromatography (SFC) II-11
Chromatography - The Widely Used Method for Separation II-12
How it Works? II-12
Chiral Mobile Phase Additive (CMPA) II-13
Chiral Stationary Phase (CSP) II-13
List of Newly Introduced Generic Versions of Derivatized
Amylose and Cellulose Phases II-14
Challenges and Novel Concepts in the Development of Chiral
Stationary Phases II-14
Novel Concepts II-14
Chiral Recognition II-15
Protein Chiral Stationary Phases II-15
Carbohydrate Columns II-15
Pirkle Columns II-15
Crystallization II-16
Solvent Extraction II-16
Kinetic Resolution II-17
Capillary Electrophoresis II-17
Receptor Based Resolution II-17
Miscellaneous Separative Techniques II-18
Chiral Synthesis II-18
4. CHIRAL TECHNOLOGY - DEVELOPMENT VIS-À-VIS ACQUISITION II-19
In-House Creation & Development II-19
Acquisition of Technology II-19
“Economics” of Chiral Technology II-20
5. CHIRAL ANALYSIS II-21
Chiral Analysis: A Primer II-21
Chiral Analysis Products II-21
Chiral Analytical Chromatography II-21
Chiral Liquid Chromatography II-21
Supercritical Fluid Chromatography - Substitute to LC for
Enantiomer Separations II-22
Chiral Gas Chromatography II-22
Chiral Simulated Moving Bed Chromatography II-22
Partition Chromatography II-22
Adsorption Chromatography II-23
Computer Assisted Resolution II-23
Chiral Polarimetry II-23
Other Chiral Analytical Techniques II-24
Calorimetry II-24
Differential Scanning Calorimetry (DSC) II-24
Enzymatic Assay II-24
Immunoassay II-24
Isotope Dilution II-25
Nuclear Magnetic Resonance (NMR) II-25
X-Ray Crystallography II-25
6. APPLICATION MARKETS II-26
Pharmaceuticals - The Largest Market II-26
Changing Face of the Pharmaceutical Industry: A Review II-26
Analysis of Chiral Drugs II-26
Select Companies Involved in Chiral Technology Market II-27
Single-Enantiomer Drugs Worldwide II-28
Drugs Built on Chiral Technology II-28
Analgesics II-28
Anesthetics II-28
Anti-Infective Products II-29
Cardiovascular System (CVS) Products II-29
Angiotensin-Converting Enzyme (ACE) Inhibitors II-29
Beta-Blockers II-29
Calcium Channel Blockers II-29
Diuretics II-30
Vasodilators II-30
Central Nervous System (CNS) Agents II-30
Anticonvulsants II-30
Sedatives and Tranquilizers II-30
Stimulants and Antidepressants II-30
Oncogenic (Cancer-Treatment) Products II-31
Biochemicals II-31
Oligonucleotides II-31
Oxyacids II-31
Amino Acids II-31
Sugars and Other Oligosaccharides II-33
Vitamins II-33
Peptides II-34
Pesticides - A Thriving Market II-34
Herbicides II-35
Insecticides II-35
Fungicides II-36
Other Products II-36
Liquid Crystals II-36
Flavor and Aroma Chemicals II-36
7. CHIRAL ISOMERISM II-37
Organic Chemical Isomerism Types II-37
Structural Isomerism II-37
Chain Isomerism II-37
Position Isomerism II-37
Functional Group Isomerism II-37
Stereoisomerism II-37
Dynamic Isomerism (Tautomerism) II-38
Patents II-38
8. REGULATORY & ENVIRONMENTAL ISSUES - A REVIEW II-39
9. PRODUCT INTRODUCTIONS/INNOVATIONS II-40
Phenomenex Introduces Chiral Screening Service II-40
AminoLogics Develops a Novel Chiral Converting Molecule for
Amino Acids II-40
Chiral Technologies Worldwide to Display 3-ìm and Protein-
based Reversed Phase Columns II-40
Chiral Technologies Introduces 3µm Chiral Stationary Phases
for Rapid Analysis II-41
Chiral Technologies Introduces 5µm Versions of Polysaccharide-
Based Chiral Stationary II-41
Semba Launches Semba Octave™ Chromatography System II-41
Modular SFC to Launch Chiral Centrifugal Fraction Collector
and Sample Concentration System II-42
Chiral Technologies Introduces New Versions of Immobilized IC
and IA Chiral Phases II-42
PDR-Chiral Develops AutoMDS for Automated Screening of Chiral
and Achiral Substances II-43
10. PRODUCT INTRODUCTIONS/INNOVATIONS - A HISTORIC PERSPECTIVE
BUILDER II-44
Waters Introduces New Products Under the UPLC Line II-44
Sigma-Aldrich/Supelco Introduces Astec CHIROBIOTIC™ Chiral
HPLC Columns II-44
Sigma-Aldrich/Supelco Introduces Astec CYCLOBOND™ Chiral HPLC
Columns II-45
Chiral Technologies Introduces CHIRALPAK® IC Columns Under
Polysaccharide Product Range II-45
Degussa Develops Novel Processes to Synthesize (S) CAP II-45
Regis Technologies, Inc. Launches RegisPack Chiral Columns II-46
Sigma-Aldrich Introduces ChiroSolv™ Kits II-46
Sigma-Aldrich Launches Ascentis Express HPLC Columns II-46
Evolved Nanomaterial Releases Revolutionary Analytical Chiral
Column II-46
BASF Develops Novel Process to Produce Chiral Intermediates II-47
Sepiatech Launches Sepmatix Parallel HPLC system II-47
MACHEREY-NAGEL Launches Novel NUCLEOCEL CSP Columns II-47
11. RECENT INDUSTRY ACTIVITY II-49
Daicel Chemical Industries Announces Renaming to Daicel Corp. II-49
WR Grace Takes Over Synthetech II-49
Daicel Chiral to Start a New Branch in Beijing II-49
Saltigo Concludes Process Development Agreement with Reuter
Chemische II-49
Chiral Technologies Europe Inks Global Licensing Agreement
with University of Vienna II-50
Shasun Announces Change of Name II-50
CT Worldwide Announces the Launch of a Novel Microsite II-50
Chiral Technologies Partners with Vanderbilt University’s
Program in Drug Discovery II-50
DSM Renews Co-Operation Agreement with Fudan University II-51
Chiral Technologies Europe Inks Distribution Agreement with
HICHROM II-51
12. STRATEGIC CORPORATE DEVELOPMENTS - A HISTORIC PERSPECTIVE BUILDER II-52
Dow Sells Dowpharma Small Molecules Business II-52
Daicel Chemical Establishes New Subsidiary in China II-52
Chiral Technologies Europe Takes Over ChromTech II-52
Cambrex to Buy ProSyntest AS II-52
Johnson Matthey and X-Zyme Sign Licensing Agreement II-53
Chiral Quest Starts a New Production Facility II-53
Chiral Quest Completes Reverse Merger with Surg II II-53
DSM and IEP Extend Partnership II-53
Shasun Chemicals Acquires Rhodia Pharma Solutions II-54
Sigma-Aldrich Corp Acquires Astec II-54
Solvias Receives License for MeOBIPHEP Catalyst Technology II-54
Codexis Acquires Juelich Fine Chemicals II-54
13. FOCUS ON SELECT PLAYERS II-55
Albemarle Corporation (USA) II-55
BASF SE (Germany) II-55
Cambrex Corp. (USA) II-55
Chiral Quest Inc. (US) II-56
Dalco ChromTech AB (Sweden) II-56
Daicel Corporation (Japan) II-56
Chiral Technologies Worldwide II-57
Chiral Technologies, Inc. (USA) II-57
Chiral Technologies Europe (France) II-57
DSM Pharmaceutical Products (The Netherlands) II-57
Johnson Matthey PLC (UK) II-58
Regis Technologies, Inc. (USA) II-58
Shasun Pharmaceuticals Limited (India) II-59
Solvias (Switzerland) II-59
Sigma Aldrich Corp. (USA) II-59
Suven Life Sciences Ltd. (USA) II-59
14. GLOBAL MARKET PERSPECTIVE II-61
Table 3: World Recent Past, Current & Future Analysis for
Chiral Technology Enabling Products by Geographic Region - US,
Japan, Europe, and Rest of World Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2009 through 2017 (includes corresponding Graph/Chart) II-61
Table 4: World Historic Review for Chiral Technology Enabling
Products by Geographic Region - US, Japan, Europe, and Rest of
World Markets Independently Analyzed with Annual Sales Figures
in US$ Million for Years 2003 through 2008 (includes
corresponding Graph/Chart) II-62
Table 5: World 15-Year Perspective for Chiral Technology
Enabling Products by Geographic Region - Percentage Breakdown
of Value Sales for US, Japan, Europe, and Rest of World
Markets for Years 2003, 2011 & 2017 (includes corresponding
Graph/Chart) II-63
Table 6: World Recent Past, Current & Future Analysis for
Chiral Intermediates by Geographic Region - US, Japan, Europe,
and Rest of World Markets Independently Analyzed with Annual
Sales Figures in US$ Million for Years 2009 through 2017
(includes corresponding Graph/Chart) II-64
Table 7: World Historic Review for Chiral Intermediates by
Geographic Region - US, Japan, Europe, and Rest of World
Markets Independently Analyzed with Annual Sales Figures in
US$ Million for Years 2003 through 2008 (includes
corresponding Graph/Chart) II-65
Table 8: World 15-Year Perspective for Chiral Intermediates by
Geographic Region - Percentage Breakdown of Value Sales for
US, Japan, Europe, and Rest of World Markets for Years 2003,
2011 & 2017 (includes corresponding Graph/Chart) II-66
Table 9: World Recent Past, Current & Future Analysis for
Chiral Analytical Products by Geographic Region - US, Japan,
Europe, and Rest of World Markets Independently Analyzed with
Annual Sales Figures in US$ Million for Years 2009 through
2017 (includes corresponding Graph/Chart) II-67
Table 10: World Historic Review for Chiral Analytical Products
by Geographic Region - US, Japan, Europe, and Rest of World
Markets Independently Analyzed with Annual Sales Figures in
US$ Million for Years 2003 through 2008 (includes
corresponding Graph/Chart) II-68
Table 11: World 15-Year Perspective for Chiral Analytical
Products by Geographic Region - Percentage Breakdown of Value
Sales for US, Japan, Europe, and Rest of World Markets for
Years 2003, 2011 & 2017 (includes corresponding Graph/Chart) II-69
Table 12: World Recent Past, Current & Future Analysis for
Other* Chiral Technology Enabling Products by Geographic
Region - US, Japan, Europe, and Rest of World Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2009 through 2017 (includes corresponding
Graph/Chart) II-70
Table 13: World Historic Review for Other* Chiral Technology
Enabling Products by Geographic Region - US, Japan, Europe,
and Rest of World Markets Independently Analyzed with Annual
Sales Figures in US$ Million for Years 2003 through 2008
(includes corresponding Graph/Chart) II-71
Table 14: World 15-Year Perspective for Other* Chiral
Technology Enabling Products by Geographic Region - Percentage
Breakdown of Value Sales for US, Japan, Europe, and Rest of
World Markets for Years 2003, 2011 & 2017 (includes
corresponding Graph/Chart) II-72
Table 15: World Recent Past, Current & Future Analysis for
Chiral Technology in Pharmaceuticals by Geographic Region -
US, Japan, Europe, and Rest of World Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2009 through 2017 (includes corresponding Graph/Chart) II-73
Table 16: World Historic Review for Chiral Technology in
Pharmaceuticals by Geographic Region - US, Japan, Europe, and
Rest of World Markets Independently Analyzed with Annual Sales
Figures in US$ Million for Years 2003 through 2008 (includes
corresponding Graph/Chart) II-74
Table 17: World 15-Year Perspective for Chiral Technology in
Pharmaceuticals by Geographic Region - Percentage Breakdown of
Value Sales for US, Japan, Europe, and Rest of World Markets
for Years 2003, 2011 & 2017 (includes corresponding
Graph/Chart) II-75
Table 18: World Recent Past, Current & Future Analysis for
Chiral Technology in Agrochemicals by Geographic Region - US,
Japan, Europe, and Rest of World Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2009 through 2017 (includes corresponding Graph/Chart) II-76
Table 19: World Historic Review for Chiral Technology in
Agrochemicals by Geographic Region - US, Japan, Europe, and
Rest of World Markets Independently Analyzed with Annual Sales
Figures in US$ Million for Years 2003 through 2008 (includes
corresponding Graph/Chart) II-77
Table 20: World 15-Year Perspective for Chiral Technology in
Agrochemicals by Geographic Region - Percentage Breakdown of
Value Sales for US, Japan, Europe, and Rest of World Markets
for Years 2003, 2011 & 2017 (includes corresponding
Graph/Chart) II-78
III. MARKET
1. THE UNITED STATES III-1
A.Market Analysis III-1
Overview III-1
B.Market Analytics III-2
Table 21: The US Recent Past, Current and Future Analysis
for Chiral Technology Enabling Products by Product Segment -
Intermediates, Analytical, and Other Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2009 through 2017 (includes corresponding Graph/Chart) III-2
Table 22: The US Historic Review for Chiral Technology
Enabling Products by Product Segment - Intermediates,
Analytical, and Other Markets Independently Analyzed with
Annual Sales Figures in US$ Million for Years 2003 through
2008 (includes corresponding Graph/Chart) III-3
Table 23: The US 15-Year Perspective for Chiral Technology
Enabling Products by Product Segment - Percentage Breakdown
of Value Sales for Intermediates, Analytical, and Other
Markets for Years 2003, 2011 & 2017 (includes corresponding
Graph/Chart) III-4
Table 24: The US Recent Past, Current & Future Analysis for
Chiral Technology by End-Use Segment - Pharmaceuticals, and
Agrochemicals Markets Independently Analyzed with Annual
Sales Figures in US$ Million for Years 2009 through 2017
(includes corresponding Graph/Chart) III-5
Table 25: The US Historic Review for Chiral Technology by
End-Use Segment - Pharmaceuticals, and Agrochemicals Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2003 through 2008 (includes corresponding
Graph/Chart) III-6
Table 26: The US 15-Year Perspective for Chiral Technology
by End-Use Segment - Percentage Breakdown of Value Sales for
Pharmaceuticals, and Agrochemicals Markets for Years 2003,
2011 & 2017 (includes corresponding Graph/Chart) III-7
2. JAPAN III-8
Market Analytics III-8
Table 27: Japanese Recent Past, Current & Future Analysis
for Chiral Technology Enabling Products by Product Segment -
Intermediates, Analytical, and Other Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2009 through 2017 (includes corresponding Graph/Chart) III-8
Table 28: Japanese Historic Review for Chiral Technology
Enabling Products by Product Segment - Intermediates,
Analytical, and Other Markets Independently Analyzed with
Annual Sales Figures in US$ Million for Years 2003 through
2008 (includes corresponding Graph/Chart) III-9
Table 29: Japanese 15-Year Perspective for Chiral Technology
Enabling Products by Product Segment - Percentage Breakdown
of Value Sales for Intermediates, Analytical, and Other
Markets for Years 2003, 2011 & 2017 (includes corresponding
Graph/Chart) III-10
Table 30: Japanese Recent Past, Current & Future Analysis
for Chiral Technology by End-Use Segment - Pharmaceuticals,
and Agrochemicals Markets Independently Analyzed with Annual
Sales Figures in US$ Million for Years 2009 through 2017
(includes corresponding Graph/Chart) III-11
Table 31: Japanese Historic Review for Chiral Technology by
End-Use Segment - Pharmaceuticals, and Agrochemicals Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2009 through 2017 (includes corresponding
Graph/Chart) III-12
Table 32: Japanese 15-Year Perspective for Chiral Technology
by End-Use Segment - Percentage Breakdown of Value Sales for
Pharmaceuticals and Agrochemicals Markets for Years 2003,
2011 & 2017 (includes corresponding Graph/Chart) III-13
3. EUROPE III-14
A.Market Analysis III-14
Overview III-14
B.Market Analytics III-15
Table 33: European Recent Past, Current & Future Analysis
for Chiral Technology Enabling Products by Product Segment -
Intermediates, Analytical, and Other Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2009 through 2017 (includes corresponding Graph/Chart) III-15
Table 34: European Historic Review for Chiral Technology
Enabling Products by Product Segment - Intermediates,
Analytical, and Other Markets Independently Analyzed with
Annual Sales Figures in US$ Million for Years 2003 through
2008 (includes corresponding Graph/Chart) III-16
Table 35: European 15-Year Perspective for Chiral Technology
Enabling Products by Product Segment - Percentage Breakdown
of Value Sales for Intermediates, Analytical, and Other
Markets for Years 2003, 2011 & 2017 (includes corresponding
Graph/Chart) III-17
Table 36: European Recent Past, Current and Future Analysis
for Chiral Technology by End-Use Segment - Pharmaceuticals,
and Agrochemicals Markets Independently Analyzed with Annual
Sales Figures in US$ Million for Years 2009 through 2017
(includes corresponding Graph/Chart) III-18
Table 37: European Historic Review for Chiral Technology by
End-Use Segment - Pharmaceuticals, and Agrochemicals Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2003 through 2008 (includes corresponding
Graph/Chart) III-19
Table 38: European 15-Year Perspective for Chiral Technology
by End-Use Segment - Percentage Breakdown of Value Sales for
Pharmaceuticals, and Agrochemicals Markets for Years 2003,
2011 & 2017 (includes corresponding Graph/Chart) III-20
4. REST OF WORLD III-21
A.Market Analysis III-21
India III-21
Chiral Drugs in the Indian Market III-21
China-A Hub for Pharmaceutical Manufacturing III-21
B.Market Analytics III-22
Table 39: Rest of World Recent Past, Current & Future
Analysis for Chiral Technology Enabling Products by Product
Segment - Intermediates, Analytical, and Other Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2009 through 2017 (includes corresponding
Graph/Chart) III-22
Table 40: Rest of World Historic Review for Chiral
Technology Enabling Products by Product Segment -
Intermediates, Analytical, and Other Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2003 through 2008 (includes corresponding Graph/Chart) III-23
Table 41: Rest of World 15-Year Perspective for Chiral
Technology Enabling Products by Product Segment - Percentage
Breakdown of Value Sales for Intermediates, Analytical, and
Other Markets for Years 2003, 2011 & 2017 (includes
corresponding Graph/Chart) III-24
Table 42: Rest of World Recent Past, Current & Future
Analysis for Chiral Technology by End-Use Segment -
Pharmaceuticals, and Agrochemicals Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2009 through 2017 (includes corresponding Graph/Chart) III-25
Table 43: Rest of World Historic Review for Chiral
Technology by End-Use Segment - Pharmaceuticals, and
Agrochemicals Markets Independently Analyzed with Annual
Sales Figures in US$ Million for Years 2003 through 2008
(includes corresponding Graph/Chart) III-26
Table 44: Rest of World 15-Year Perspective for Chiral
Technology by End-Use Segment - Percentage Breakdown of
Value Sales for Pharmaceuticals, and Agrochemicals Markets
for Years 2003, 2011 & 2017 (includes corresponding
Graph/Chart) III-27
IV. COMPETITIVE LANDSCAPE
Total Companies Profiled: 37 (including Divisions/Subsidiaries - 46)
------------------------------------------
Region/Country Players
------------------------------------------
The United States 27
Canada 1
Japan 2
Europe 12
France 4
Germany 1
The United Kingdom 2
Italy 1
Rest of Europe 4
Asia-Pacific (Excluding Japan) 4
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