World Orthopedic Prosthetics Market

World Orthopedic Prosthetics Market

This report analyzes the worldwide markets for Orthopedic Prosthetics in Millions of US$. The specific product segments analyzed are Hip Prosthesis, Knee Prosthesis, and Secondary Joint Prosthesis (Shoulder Prosthesis, & Other Secondary Joint Prosthesis). The report provides separate comprehensive analytics for the US, Canada, Japan, Europe, Asia Pacific, Latin America, and Rest of World. Annual forecasts are provided for each region for the period of 2001 through 2015. A ten-year historic analysis is also provided for these markets with annual market analytics. The report profiles 64 companies including many key and niche players worldwide such as Biomet Inc., Corin Group PLC, DePuy Orthopedics Inc., DJO Surgical, Smith & Nephew PLC, Stryker Corp., Wright Medical Group Inc., and Zimmer Holdings Inc. Market data and analytics are derived from primary and secondary research. Company profiles are mostly extracted from URL research and reported select online sources.

ORTHOPEDIC PROSTHETICS MCP-3224
A GLOBAL STRATEGIC BUSINESS REPORT


CONTENTS


I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS
Study Reliability and Reporting Limitations I-1
Disclaimers I-2
Data Interpretation & Reporting Level I-2
Quantitative Techniques & Analytics I-3
Product Definitions and Scope of Study I-3
Hip Prosthesis I-3
Knee Prosthesis I-4
Secondary Joint Prosthesis I-4

II. EXECUTIVE SUMMARY

1. Global Market Overview and Analysis II-1
Current and Future Analysis II-1
Major Growth Drives for the Industry II-1
Growing Obese Population Drives Demand for Joint Replacement
Surgeries II-2
Rising Life Expectancy & Active Lifestyle Drive Demand for
Joint Replacement Procedures II-2
Cost Containment Issues II-2
Developing Markets Hold Enormous Growth Potential II-2
Revision Procedures Buoy Growth II-3
Minimally Invasive Surgery - Attracts Attention II-3
Demand for Premium Implants Continues II-3
Growing Demand for Total Hip Replacement in Young People II-3
Hip Resurfacing Replacement - for Younger Generation II-4
Gender-Specific Orthopedic Devices Gain Momentum II-4

2. Competitive Scenario II-5
Mergers and Acquisitions Timeline in the Worldwide Orthopedic
Prosthetics Industry: 1997-2006 II-5
Table 1: Leading Players in Worldwide Orthopedic
Prosthetics/Reconstructive Market (2005): Percentage
Breakdown of Value Sales for Zimmer, DePuy (J&J), Stryker,
Biomet, Smith & Nephew, and Others (includes corresponding
Graph/Chart) II-6

Table 2: Leading Players in Worldwide Hip Prosthesis Market
(2004-2006): Percentage Breakdown of Dollar Sales by Company
for Zimmer,J&J DePuy, Stryker, Biomet, Smith & Nephew, Wright
Medical, and Others (includes corresponding Graph/Chart) II-6

Table 3: Leading Players in Worldwide Knee Prosthesis Market
(2004-2006): Percentage Breakdown of Dollar Sales by Company
for Zimmer Holdings, J&J DePuy, Stryker Corporation, Biomet,
Smith & Nephew, and Others (includes corresponding
Graph/Chart) II-7

Table 4: Leading Players in World Market for Extremities
(2004-2006E) - Percentage Share Breakdown of Dollar Sales by
Company for DePuy, Zimmer, Stryker, Biomet, Smith & Nephew
Orthopedics, and Others (includes corresponding Graph/Chart) II-7
Peer Group Analysis II-8
Zimmer Holdings, Inc. II-8
DePuy, Inc. II-8
Stryker Corp. II-9
Biomet, Inc. II-9
Smith& Nephew, Inc. II-10

3. Foreword to the Orthopedic Industry II-11
Mergers and Acquisitions in the Worldwide Orthopedics
Industry: 1997-2007 II-11
Orthopedic Orthotics & Prosthetics II-12
Table 5: Global Orthopedic Market (2005): Percentage
Breakdown of Value Sales for Reconstructive Joint
Replacement, Spine, Trauma and Craniomaxillofacial, Operating
Room Equipment, Orthobiologics, Arthroscopy, and Others
(includes corresponding Graph/Chart) II-12

4. Orthopedic Prosthetics- Product Overview II-13
Hip Prostheses II-13
Total Hip Replacement II-13
Conditions Requiring Total Hip Replacement II-13
Materials Used... II-14
Cemented Hip Implants II-14
Cementless Hip Implants II-14
Complications Following THR II-14
Partial Hip Replacement II-14
Revision Hip Procedures II-14
Types of Hip Implants II-15
Ceramic-on-Ceramic II-15
Metal-on-Metal II-15
Highly Cross-Linked Polyethylene II-16
Ceramic-on-Polyethylene II-16
Metal-on-Polyethylene II-16
Product Portfolio of Major Players in the Hip Implants Market II-16
Knee Prostheses II-16
Functional Aspects of the Knee II-17
Implant Design II-17
Unicondylar Knee Replacements II-17
Fixed and Mobile Bearing Knees II-18
Mobile Bearing Total Knee Replacement Prostheses II-18
Revision Surgeries II-18
Secondary Joint Prostheses II-18
Shoulder Prosthesis II-19
Ankle Prosthesis II-19
Elbow Prosthesis II-19
Finger Prosthesis II-19

5. Product Trends II-20
Alternate-Bearing Materials in the Hip Implants Market II-20
Diamond-on-Diamond Technology II-20
Cementless Procedures Gain Ground II-20
Trabecular Metal Technology II-21
Surface Modification Technology II-21
Novel Minimally Invasive Approaches II-21
Zimmer Launches Quad-Sparing Total Knee Replacement II-21
Zimmer Launches New Minimally Invasive Hip Procedure Hip
Procedure II-21
DePuy Orthopaedics Introduces New Mini-Incision Technique in
Hip Replacement II-22

6. Major Prosthesis Technologies - An Overview II-23
Artificial Disc Technology II-23
Artificial Total Disc II-24
Allografts II-25
Osteoinductive Agents/Bone Graft Factors II-25
The Hip Hinge Technology II-26
Resorbables II-26
Cell Therapy - Chondrocyte Transplantation II-26

7. Recent Technological Developments II-27
Innovative Joint Prosthesis Developed II-27
US-Based Inventor Designs New Knee Prosthesis II-27
US Inventors Develop New Modular Prosthetic Knee System II-27
Californian Inventor Develops Orthopedic Implant Surface
Configuration II-27
Indiana Inventor Designs New Prosthetic Implant II-27
New Orthopedic Implant Application Method Developed II-27
US-Based Inventors Develops Stem Extension for Leg and Knee
Implants II-28
US-Based Inventor Develops New Prosthesis Hip Implant II-28

8. Product Innovations/Introductions II-29
FDA Grants Approval for DJO’s X-alt™ Polyethylene Liner II-29
Smith & Nephew Introduce R3? Acetabular System II-29
Smith & Nephew Introduces VERILAST? Knee Replacement Technology II-29
Exactech to Launch New Cartilage Repair Technology II-29
Wright Medical Expands Orthopedic Hip Offerings II-29
Zimmer Holdings Introduces Zimmer® DTO™ Implants II-30
Japan Regulatory Approves Wright’s CONSERVE® Plus II-30
Smith & Nephew Rolls Out Globally JOURNEY? DEUCE? Knee System II-30
Wright Extends its Hip Product Offerings II-30
FDA Approves Cormet™ Hip Resurfacing System of Corin II-31
Exactech Gains FDA Clearance for its Novation™ Ceramic AHS™
Hip System II-31
Biomet to Roll Out Minimally Invasive Hip Stems II-31
Wright Launches EVOLVE® PROLINE System II-31
AIC Receives CE Mark Approval for its New AIC Hip Buffer™
Polymer Implant II-32
Portland Gains FDA Approval to Market Beacon Primary Knee
System in the US II-32
Portland Develops a New Cemented Hip Replacement Product II-32
Smith and Nephew Receives FDA Clearance to Market Birmingham
Hip Brand in the US II-32
Kobayashi Rolls Out New Kiapex Hip Prosthesis System II-33
ABS Gains FDA and CE Mark Approvals for its OrthoGlide Medial
Knee Implant II-33
FDA Approves Biomet’s Regenerex™ Porous Titanium Construct
Acetabular System II-33
Smith & Nephew Introduces New JOURNEY* Bi-Cruciate Stabilized
Knee System II-33
Wright Medical Unveils New CLAWT Plate for Foot & Ankle
Reconstructive Surgeries II-34
Wright Medical Introduces New PROFEMUR® RENAISSANCE™ Total Hip
System II-34
Wright Medical Group Rolls Out A-CLASS™ Polyethylene Liner for
LINEAGE® Hip Implants II-34
FDA Grants PMA Clearance for Zimmer’s Trilogy AB® Ceramic-on-
Ceramic Acetabular System II-34
Zimmer Develops Implant Systems Based on Trabecular Metal
Technology II-34
FDA Clears Zimmer’s Gender Solutions Artificial Knee for Women II-35
Stryker Launches Triathlon Knee System for Women II-35
DePuy Introduces ASR XL Metal-on-Metal Total Hip Replacement
Device II-35
Smith & Nephew Introduces New EMPERION* Modular Hip System II-35
FDA Clears Stryker’s LFIT(TM) Anatomic Femoral Heads with X3(
R) Liners II-36
Wright Medical Unveils CHARLOTTE™ Foot & Ankle System II-36
Wright Medical Group Introduces A-CLASS™ Advanced Metal II-36
Smith & Nephew Unveils AchieveCAS* for Performing Accurate
Knee Implant Procedures II-36
Smith & Nephew Unveils LEGION Revision Knee System with
OXINIUM Material II-37
Encore Gains FDA Approval - To Market New Reverse Shoulder
Prosthesis® II-37
FDA Approves Biomet’s C2a-Taper™ Ceramic-On- Ceramic Hip System II-37
Biomet Obtains FDA Clearance for ArComXL™ II-37
DePuy Orthopedics Introduces New Biologic Shoulder Implant II-38
Zimmer Launches First High Flexion Unicompartmental Knee II-38
DePuy Orthopaedics Introduces Uni-Compartmental Knee Implant II-38
DePuy Orthopaedics Introduces Agility™ Total Ankle System II-39
Biomet’s Meniscal Unicompartmental System in the US II-39
Smith & Nephew’s Uncemented Porous Coated Knees II-39
Smith & Nephew’s Bone Graft Substitute II-39
Stryker’s Revolutionary Ceramic-on-ceramic Hip Replacement in
the US II-39
Wright Medical’s Ceramic Hip II-39

9. Recent Industry Activity II-40
Wright Medical to Take Over INBONE Technologies II-40
Encore Medical of DJO Renamed to DJO Surgical II-40
Wright Medical Acquires Foot Surgery Division of DARCO
International II-40
Smith & Nephew Acquires Plus Orthopedics II-40
DJO Concludes Merger with ReAble Therapeutics II-41
Wright Medical Purchases Metasurg’s Foot and Ankle Implants II-41
Wright Medical Buys External Fixation Product Line of R&R Medical II-41
Regeneration Technologies and Wright Medical Partner to
Develop Innovative Implants II-41
Biomet Merges with LVB Acquisition II-41
Kensey Nash and Biomet Sign Exclusive Distribution Agreement II-41
FDA Approves Zimmer® NexGen® LPS-Flex Mobile Knee II-42
Regeneration Technologies and Zimmer Holdings Ink 10-year
Distribution Agreement II-42
Corin and Stryker Enter into a Distribution Concord II-42
Blackstone Capital Partners Inks Definitive Agreement to
Acquire Encore II-42
Integra Takes Over KMI in a Cash Transaction II-42
MAKO Licenses New Orthopedic Implant Material Rights from UF II-43
Hanger Acquires Regional Artificial Limb & Brace Co. and
Temple Medical II-43
Stryker Enters into Distribution Agreement with Corin Group II-43
Smith & Nephew Inks Exclusive Licensing Agreement with ART for
Developing Knee Prosthetic II-43
Encore Medical Takes Over Osteoimplant Technology II-43
Stryker & Wright Medical Award Titanium Powder Contract to AP&C II-44
Corin Group Establishes New Subsidiary in China II-44
Zimmer Completes the Acquisition of Implex II-44
Smith & Nephew Acquires MMT II-44
Exactech Acquires Total Shoulder System of Teknimed II-44
Zimmer Acquires Centerpulse II-45
Hanger Acquires Advanced Bio-Mechanics and Northern Virginia
Orthotics & Prosthetics II-45
Virtual Scopics Collaborates with Anderson Orthopaedic
Research Institute II-45

10. Focus on Select Players II-46
Biomet, Inc. (US) II-46
Corin Group PLC (UK) II-46
DePuy Orthopedics, Inc. (USA) II-46
DJO Surgical (USA) II-46
Smith & Nephew Plc (UK) II-47
Stryker Corp. (USA) II-47
Wright Medical Group, Inc. (USA) II-48
Zimmer Holdings, Inc. (USA) II-48

11. Global Market Perspective II-49
Table 6: World Recent Past, Current & Future Analysis for
Orthopedic Prosthetics by Geographic Region - US, Canada,
Japan, Europe, Asia-Pacific (excluding Japan), Latin America
and Rest of World Independently Analyzed with Annual Sales
Figures in US$ Million for Years 2001 through 2010 (includes
corresponding Graph/Chart) II-49

Table 7: World Long-term Projections Orthopedic Prosthetics by
Geographic Region - US, Canada, Japan, Europe, Asia-Pacific
(excluding Japan), Latin America and Rest of World
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2011 through 2015 (includes corresponding
Graph/Chart) II-50

Table 8: World Historic Review for Orthopedic Prosthetics by
Geographic Region - US, Canada, Japan, Europe, Asia-Pacific
(excluding Japan), Latin America and Rest of World
Independently Analyzed with Annual Sales Figures in US$
Million for Years 1995 through 2000 (includes corresponding
Graph/Chart) II-51

Table 9: World 15-Year Perspective for Orthopedic Prosthetics
by Geographic Region - Percentage Breakdown of Dollar Sales
for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan),
Latin America and Rest of World Markets for Years 1998, 2008,
& 2012 (includes corresponding Graph/Chart) II-52

Table 10: World Recent Past, Current & Future Analysis for Hip
Prosthesis by Geographic Region - US, Canada, Japan, Europe,
Asia-Pacific (excluding Japan), Latin America and Rest of
World Independently Analyzed with Annual Sales Figures in US$
Million for Years 2001 through 2010 (includes corresponding
Graph/Chart) II-53

Table 11: Term-term Projections Hip Prosthesis by Geographic
Region - US, Canada, Japan, Europe, Asia-Pacific (excluding
Japan), Latin America and Rest of World Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2001
through 2010 (includes corresponding Graph/Chart) II-54

Table 12: World Historic Review for Hip Prosthesis by
Geographic Region - US, Canada, Japan, Europe, Asia- Pacific
(excluding Japan), Latin America and Rest of World
Independently Analyzed with Annual Sales Figures in US$
Million for Years 1995 through 2000 (includes corresponding
Graph/Chart) II-55

Table 13: World 15-Year Perspective for Hip Prosthesis by
Geographic Region - Percentage Breakdown of Dollar Sales for
US, Canada, Japan, Europe, Asia-Pacific (excluding Japan),
Latin America and Rest of World Markets for Years 1998, 2008,&
2012 (includes corresponding Graph/Chart) II-56

Table 14: World Recent Past, Current & Future Analysis for
Knee Prosthesis by Geographic Region - US, Canada, Japan,
Europe, Asia-Pacific (excluding Japan), Latin America and Rest
of World Independently Analyzed with Annual Sales Figures in
US$ Million for Years 2001 through 2010 (includes
corresponding Graph/Chart) II-57

Table 15: WorldLong-term Projections Knee Prosthesis by
Geographic Region - US, Canada, Japan, Europe, Asia- Pacific
(excluding Japan), Latin America and Rest of World
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2001 through 2010 (includes corresponding
Graph/Chart) II-58

Table 16: World Historic Review for Knee Prosthesis by
Geographic Region - US, Canada, Japan, Europe, Asia-Pacific
(excluding Japan), Latin America and Rest of World
Independently Analyzed with Annual Sales Figures in US$
Million for Years 1995 through 2000 (includescorresponding
Graph/Chart) II-59

Table 17: World 15-Year Perspective for Knee Prosthesis by
Geographic Region - Percentage Breakdown of Dollar Sales for
US, Canada, Japan, Europe, Asia-Pacific (excluding Japan),
Latin America and Rest of World Markets for Years 1998, 2008,&
2012 (includes corresponding Graph/Chart) II-60

Table 18: World Recent Past, Current & Future Analysis for
Secondary Joint Prosthesis by Geographic Region - US, Canada,
Japan, Europe, Asia-Pacific (excluding Japan), Latin America
and Rest of World Independently Analyzed with Annual Sales
Figures in US$ Million for Years 2001 through 2010 (includes
corresponding Graph/Chart) II-61

Table 19: WorldLong-term Projections Secondary Joint
Prosthesis by Geographic Region - US, Canada, Japan, Europe,
Asia-Pacific (excluding Japan), Latin America and Rest of
World Independently Analyzed with Annual Sales Figures in US$
Million for Years 2011 through 2015 (includes corresponding
Graph/Chart) II-62

Table 20: World Historic Review for Secondary Joint Prosthesis
by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific
(excluding Japan), Latin America and Rest of World
Independently Analyzed with Annual Sales Figures in US$
Million for Years 1995 through 2000 (includes corresponding
Graph/Chart) II-63

Table 21: World 15-Year Perspective for Secondary Joint
Prosthesis by Geographic Region - Percentage Breakdown of
Value Sales for US, Canada, Japan, Europe, Asia-Pacific
(excluding Japan), Latin America and Rest of World Markets for
Years 1998, 2008,& 2012 (includes corresponding Graph/Chart) II-64

Table 22: World Recent Past, Current & Future Analysis for
Secondary Joint Prosthesis by Product Segment - Shoulder and
Other Secondary Joint Prosthesis Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2001 through 2010 (includes corresponding Graph/Chart) II-65

Table 23: World Long-term Projections for Secondary Joint
Prosthesis by Product Segment - Shoulder and Other Secondary
Joint Prosthesis Markets Independently Analyzed with Annual
Sales Figures in US$ Million for Years 2011 through 2015
(includes corresponding Graph/Chart) II-66

Table 24: World Historic Review for Secondary Joint Prosthesis
by by Product Segment - Shoulder and Other Secondary Joint
Prosthesis Markets Independently Analyzed with Annual Sales
Figures in US$ Million for Years 1995 through 2000 (includes
corresponding Graph/Chart) II-67

Table 25: World 15-Year Perspective for Secondary Joint
Prosthesis for Secondary Joint Prosthesis by Product Segment -
Shoulder and Other Secondary Joint Prosthesis Markets for
Years 1998, 2008 & 2012 II-67

Table 26: World Recent Past, Current & Future Analysis for
Shoulder Prosthesis by Geographic Region - US, Canada, Japan,
Europe, Asia-Pacific (excluding Japan), Latin America and Rest
of World Independently Analyzed with Annual Sales Figures in
US$ Million for Years 2001 through 2010 (includes
corresponding Graph/Chart) II-68

Table 27: WorldLong-term Projections Shoulder Prosthesis by
Geographic Region - US, Canada, Japan, Europe, Asia-Pacific
(excluding Japan), Latin America and Rest of World
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2011 through 2015 (includes corresponding
Graph/Chart) II-69

Table 28: World Historic Review for Shoulder Prosthesis by
Geographic Region - US, Canada, Japan, Europe, Asia- Pacific
(excluding Japan), Latin America and Rest of World
Independently Analyzed with Annual Sales Figures in US$
Million for Years 1995 through 2000 (includes corresponding
Graph/Chart) II-70

Table 29: World 15-Year Perspective for Shoulder Prosthesis by
Geographic Region - Percentage Breakdown of Dollar Sales for
US, Canada, Japan, Europe, Asia-Pacific (excluding Japan),
Latin America and Rest of World Markets for Years 1998, 2008,&
2012 (includes corresponding Graph/Chart) II-71

Table 30: World Recent Past, Current & Future Analysis Other
Secondary Joint Prosthesis by Geographic Region - US, Canada,
Japan, Europe, Asia-Pacific (excluding Japan), Latin America
and Rest of World Markets Independently Analyzed with Annual
Sales Figures in US$ Million for Years 2001 through 2010
(includes corresponding Graph/Chart) II-72

Table 31: World Long-term Projections for Other Secondary
Joint Prosthesis by Geographic Region - US, Canada, Japan,
Europe, Asia-Pacific (excluding Japan), Latin America and Rest
of World Markets Independently Analyzed with Annual Sales
Figures in US$ Million for Years 2011 through 2015 (includes
corresponding Graph/Chart) II-73

Table 32: World Historic Review for Other Secondary Joint
Prosthesis by Geographic Region - US, Canada, Japan, Europe,
Asia-Pacific (excluding Japan), Latin America and Rest of
World Markets Independently Analyzed with Annual Sales Figures
in US$ Million for Years 1995 through 2000 (includes
corresponding Graph/Chart) II-74

Table 33: World 15-Year Perspective for Other Secondary Joint
Prosthesis by Geographic Region - Percentage Breakdown of
Value Sales for US, Canada, Japan, Europe,Asia-Pacific
(excluding Japan), Latin America and Rest of World Markets for
Years 1998, 2008 & 2012 (includes corresponding Graph/Chart) II-75

III. MARKET

1. The United States III-1
A.Market Analysis III-1
Issues & Trends III-1
Rising Demand for Hip and Knee Replacement Surgeries in the US III-1
Advancements in Prosthetic Implants Foster Demand for Joint
Replacement Procedures III-2
Reconstructive Products - Growth Drivers III-2
Demographics III-2
Table 34: Percentage of Population in terms of Age Groups
in the US (includes corresponding Graph/Chart) III-2

Table 35: Population of the Elderly in the US (in
Millions): Population of 50-54, 55-59, 60-64, 65-69 and
70-74 Age Groups for 2001(E), 2006(E) and 2011(E )
(includes corresponding Graph/Chart) III-3
Innovations: Ameliorate Industry Growth III-3
Younger Patients - New Target III-3
Price/Mix Shift III-3
Medicare Reimbursement: A Macro Catalyst III-4
Knee Implants Market III-4
Table 36: Knee Implants Market in the US (2004): Percentage
Breakdown by Value Sales for Implant Type - Cemented
Femoral, Cemented Tibial, Cementless Femoral,Cementless
Tibial and Polyethylene Liner (includes corresponding
Graph/Chart) III-4

Table 37: Knee Implant Procedures in the US: 2000- 2007 (In
Thousands) (includes corresponding Graph/Chart) III-4
Hip Implants Market III-5
New Materials Emerge as Polyethylene Alternatives III-5
Table 38: Hip Implant Procedures in the US: 2000- 2007 (In
Thousands) (includes corresponding Graph/Chart) III-5
Shift from Cemented to Press-Fit Procedures III-5
Major Players III-5
Table 39: Leading Players in the US Hip Implants Market
(2004-05): Percentage Breakdown by Value Sales for Zimmer,
Depuy, Stryker, Biomet, Smith & Nephew, Wright Medical and
Others (includes corresponding Graph/Chart) III-6

Table 40: Leading Players in the US Knee Implants Market
(2004-05): Percentage Breakdown by Value Sales for Zimmer,
Depuy, Stryker, Biomet, Smith & Nephew, Wright Medical and
Others (includes corresponding Graph/Chart) III-6
Product Launches III-7
Strategic Corporate Developments III-18
Key Players III-23
Biomet, Inc. III-23
DePuy Orthopedics, Inc. III-23
DJO Surgical III-23
Exactech, Inc. III-24
Stryker Corporation III-24
Wright Medical Group, Inc. III-25
Zimmer Holdings, Inc. III-25
B.Market Analytics III-26
Table 41: US Recent Past, Current & Future Analysis for
Orthopedic Prosthetics by Product Segment -Hip Prosthesis,
Knee Prosthesis, and Secondary Joint Prosthesis (Shoulder
Prosthesis and Other Joint Prosthesis) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2001 through 2010 (includes corresponding Graph/Chart) III-26

Table 42: US Long-term Projections for Orthopedic
Prosthetics by Product Segment -Hip Prosthesis, Knee
Prosthesis, and Secondary Joint Prosthesis (Shoulder
Prosthesis and Other Joint Prosthesis) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2001 through 2010 (includes corresponding Graph/Chart) III-27

Table 43: US Historic Review for Orthopedic Prosthetics by
Product Segment - Hip Prosthesis, Knee Prosthesis, and
Secondary Joint Prosthesis (Shoulder Prosthesis and Other
Joint Prosthesis) Markets Independently Analyzed with Annual
Sales Figures in US$ Million for Years 1995 through 2000
(includes corresponding Graph/Chart) III-27

Table 44: US 15-Year Perspective for Orthopedic Prosthetics
by Product Segment - Percentage Breakdown of Value Sales for
Hip Prosthesis, Knee Prosthesis, and Secondary Joint
Prosthesis (Shoulder Prosthesis and Other Joint Prosthesis)
Markets for 1998, 2008,& 2012 (includes corresponding
Graph/Chart) III-28

2. Canada III-29
Market Analysis III-29
Strategic Corporate Development III-29
Table 45: Canadian Recent Past, Current & Future Market
Analysis for Orthopedic Prosthetics by Product Segment -Hip
Prosthesis, Knee Prosthesis, and Secondary Joint Prosthesis
(Shoulder Prosthesis and Other Joint Prosthesis) Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2001 through 2010 (includescorresponding
Graph/Chart) III-29

Table 46: Canadian Long-term Projections for Orthopedic
Prosthetics by Product Segment -Hip Prosthesis, Knee
Prosthesis, and Secondary Joint Prosthesis (Shoulder
Prosthesis and Other Joint Prosthesis) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2011 through 2015 (includescorresponding Graph/Chart) III-30

Table 47: Canadian Historic Review for Orthopedic
Prosthetics by Product Segment - Hip Prosthesis, Knee
Prosthesis, and Secondary Joint Prosthesis (Shoulder
Prosthesis and Other Joint Prosthesis) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
1995 through 2000 (includes corresponding Graph/Chart) III-30

Table 48: Canadian 15-Year Perspective for Orthopedic
Prosthetics by Product Segment - Percentage Breakdown of
Value Sales for Hip Prosthesis, Knee Prosthesis, and
Secondary Joint Prosthesis (Shoulder Prosthesis and Other
Joint Prosthesis) Markets for 1998, 2008,& 2012 (includes
corresponding Graph/Chart) III-31

3. Japan III-32
A.Market Analysis III-32
Current & Future Analysis III-32
Growth Boosters III-32
Driven by Innovations III-32
Aging Population Propels Sales III-32
Government Resorts to Reimbursement Cuts for Orthopedics Sector III-32
Players in Japanese Orthopedic Implants Market III-33
Table 49: Leading Players in the Japanese Knee Implants
Market (2005): Percentage Breakdown by Value Sales for
Zimmer, Stryker, DePuy- J&J, Wright Medical Group, Biomet,
Smith& Nephew and Others (includes corresponding
Graph/Chart) III-33
Product Launch III-33
B.Market Analytics III-34
Table 50: Japanese Recent Past, Current & Future Market
Analysis for Orthopedic Prosthetics by Product Segment -Hip
Prosthesis, Knee Prosthesis, and Secondary Joint Prosthesis
(Shoulder Prosthesis and Other Joint Prosthesis) Markets
Independently Analyzed with Annual Sales Figures in US$
Million forYears 2001 through 2010 (includes corresponding
Graph/Chart) III-34

Table 51: Japanese Long-term Projections for Orthopedic
Prosthetics by Product Segment -Hip Prosthesis, Knee
Prosthesis, and Secondary Joint Prosthesis (Shoulder
Prosthesis and Other Joint Prosthesis) Markets Independently
Analyzed with Annual Sales Figures in US$ Million forYears
2011 through 2015 (includes corresponding Graph/Chart) III-35

Table 52: Japanese Historic Review for Orthopedic
Prosthetics by Product Segment - Hip Prosthesis, Knee
Prosthesis, and Secondary Joint Prosthesis (Shoulder
Prosthesis and Other Joint Prosthesis) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
1995 through 2000 (includes corresponding Graph/Chart) III-35

Table 53: Japanese 15-Year Perspective for Orthopedic
Prosthetics by Product Segment - Percentage Breakdown of
Value Sales for Hip Prosthesis, Knee Prosthesis, and
Secondary Joint Prosthesis (Shoulder Prosthesis and Other
Joint Prosthesis) Markets for 1998, 2008,& 2012 (includes
corresponding Graph/Chart) III-36

4. Europe III-37
A.Market Analysis III-37
Outlook III-37
Demographics Drive Growth III-37
European Hip and Knee Replacement Market III-37
Growth Drivers III-37
Increase in Elderly Population Fuels Demand for Joint
Replacement Procedures III-37
Reduced Waiting Time & Effective Clinical Outcomes Boost
Industry Prospects III-37
Revision Surgeries - A Major Growth Area III-37
Technological Advancements Ensure Higher Demand for
Replacement Procedures III-38
Market Restraints III-38
Reimbursements Scenario in Europe III-38
Competitive Scenario III-38
Trends Driving the Implants Segment III-38
Table 54: Leading Players in European Hip Implants Market
(2004): Percentage Breakdown by Value Sales for
DePuy/Johnson & Johnson, Stryker, Zimmer, Biomet and Others
(includes corresponding Graph/Chart) III-39
Modular Systems Turn the Most Common Form of Knee Implant
in Europe III-39
Table 55: Leading Players in European Knee Implants Market
(2004): Percentage Breakdown by Value Sales for DePuy-
J&J, Zimmer, Stryker, Biomet and Others (includes
corresponding Graph/Chart) III-39
B.Market Analytics III-40
Table 56: European Recent Past, Current & Future Market
Analysis for Orthopedic Prosthetics by Geographic Region -
France, Germany, UK, Italy & Rest of Europe Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2001 through 2010 (includes corresponding
Graph/Chart) III-40

Table 57: European Long-term Projections for Orthopedic
Prosthetics by Geographic Region - France, Germany, UK,
Italy & Rest of Europe Markets Independently Analyzed with
Annual Sales Figures in US$ Million for Years 2011 through
2015 (includes corresponding Graph/Chart) III-41

Table 58: European Recent Past, Current & Future Market
Analysis for Orthopedic Prosthetics by Product Segment -Hip
Prosthesis, Knee Prosthesis, and Secondary Joint Prosthesis
(Shoulder Prosthesis and Other Joint Prosthesis) Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2004 through 2010 (includes corresponding
Graph/Chart) III-42

Table 59: European Long-term Projections for Orthopedic
Prosthetics by Product Segment -Hip Prosthesis, Knee
Prosthesis, and Secondary Joint Prosthesis (Shoulder
Prosthesis and Other Joint Prosthesis) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2011 through 2015 (includes corresponding Graph/Chart) III-42

Table 60: European Historic Review for Orthopedic
Prosthetics by Geographic Region - France, Germany, UK,
Italy & Rest of Europe Markets Independently Analyzed with
Annual Sales Figures in US$ Million for Years 1995 through
2000 (includes corresponding Graph/Chart) III-43

Table 61: European Historic Review for Orthopedic
Prosthetics by Product Segment - Hip Prosthesis, Knee
Prosthesis, and Secondary Joint Prosthesis (Shoulder
Prosthesis and Other Joint Prosthesis) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
1995 through 2000 (includes corresponding Graph/Chart) III-43

Table 62: European 15-Year Perspective for Orthopedic
Prosthetics by Geographic Region - Percentage Breakdown of
Value Sales for France, Germany, UK, Italy & Rest of Europe
Markets for Years 1998, 2008,& 2012 (includes corresponding
Graph/Chart) III-44

Table 63: European 15-Year Perspective for Orthopedic
Prosthetics by Product Segment - Percentage Breakdown of
Value Sales for Hip Prosthesis, Knee Prosthesis, and
Secondary Joint Prosthesis (Shoulder Prosthesis and Other
Joint Prosthesis) Markets for 1998, 2008,& 2012 (includes
corresponding Graph/Chart) III-44

4a. France III-45
A.Market Analysis III-45
Current & Future Analysis III-45
Orthopedic Market in France III-45
Demographics Underpinning Growth III-45
Table 64: Percentage Breakdown of Population by Age Group
in France includes corresponding Graph/Chart) III-45
B.Market Analytics III-46
Table 65: French Recent Past, Current & Future Market
Analysis for Orthopedic Prosthetics by Product Segment -Hip
Prosthesis, Knee Prosthesis, and Secondary Joint Prosthesis
(Shoulder Prosthesis and Other Joint Prosthesis) Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2001 through 2010 (includes corresponding
Graph/Chart) III-46

Table 66: French Long-term Projections for Orthopedic
Prosthetics by Product Segment -Hip Prosthesis, Knee
Prosthesis, and Secondary Joint Prosthesis (Shoulder
Prosthesis and Other Joint Prosthesis) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2011 through 2015 (includes corresponding Graph/Chart) III-46

Table 67: French Historic Review for Orthopedic Prosthetics
by Product Segment - Hip Prosthesis, Knee Prosthesis, and
Secondary Joint Prosthesis (Shoulder Prosthesis and Other
Joint Prosthesis) Markets Independently Analyzed with Annual
Sales Figures in US$ Million for Years 1995 through 2000
(includes corresponding Graph/Chart) III-47

Table 68: French 15-Year Perspective for Orthopedic
Prosthetics by Product Segment - Percentage Breakdown of
Value Sales for Hip Prosthesis, Knee Prosthesis, and
Secondary Joint Prosthesis (Shoulder Prosthesis and Other
Joint Prosthesis) Markets for 1998, 2008,& 2012 (includes
corresponding Graph/Chart) III-47

4b. Germany III-48
A.Market Analysis III-48
Orthopedic Products in Germany III-48
Demographic Profile III-48
Table 69: Percentage Breakdown of Population by Age Group
in France (includes corresponding Graph/Chart) III-48
Key Players III-48
AAP Implantate AG III-48
Aesculap Implant Systems Inc III-49
B.Market Analytics III-49
Table 70: German Recent Past, Current & Future Analysis for
Orthopedic Prosthetics by Product Segment -Hip Prosthesis,
Knee Prosthesis, and Secondary Joint Prosthesis (Shoulder
Prosthesis and Other Joint Prosthesis) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2001 through 2010 (includes corresponding Graph/Chart) III-49

Table 71: German Long-term Projections Orthopedic
Prosthetics by Product Segment -Hip Prosthesis, Knee
Prosthesis, and Secondary Joint Prosthesis (Shoulder
Prosthesis and Other Joint Prosthesis) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2011 through 2015 (includes corresponding Graph/Chart) III-50

Table 72: German Historic Review for Orthopedic Prosthetics
by Product Segment - Hip Prosthesis, Knee Prosthesis, and
Secondary Joint Prosthesis (Shoulder Prosthesis and Other
Joint Prosthesis) Markets Independently Analyzed with Annual
Sales Figures in US$ Million for Years 1995 through 2000
(includes corresponding Graph/Chart) III-50

Table 73: German 15-Year Perspective for Orthopedic
Prosthetics by Product Segment - Percentage Breakdown of
Value Sales for Hip Prosthesis, Knee Prosthesis, and
Secondary Joint Prosthesis (Shoulder Prosthesis and Other
Joint Prosthesis) Markets for 1998, 2008,& 2012 (includes
corresponding Graph/Chart) III-51

4c. The United Kingdom III-52
A.Market Analysis III-52
Total Hip Replacement Statistics III-52
Shoulder & Small Joint Implants III-52
Demographic Profile III-52
Table 74: Percentage Breakdown of Population by Age Group
in UK (includes corresponding Graph/Chart) III-52
Leading Players III-52
Issues & Trends III-53
Aging Baby Boomer Generation Fuels Demand for Knee
Replacement Surgeries in the UK III-53
Trends in Primary and Revision Joint (Hip and Knee)
Replacement Procedures III-53
Key Players III-53
Corin Group PLC III-53
Finsbury Orthopaedics III-53
Smith & Nephew Plc III-53
B.Market Analytics III-54
Table 75: uk Recent Past, Current & Future Analysis for
Orthopedic Prosthetics by Product Segment -Hip Prosthesis,
Knee Prosthesis, and Secondary Joint Prosthesis (Shoulder
Prosthesis and Other Joint Prosthesis) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2004 through 2010 (includes corresponding Graph/Chart) III-54

Table 76: uk Long-term Projections Orthopedic Prosthetics by
Product Segment -Hip Prosthesis, Knee Prosthesis, and
Secondary Joint Prosthesis (Shoulder Prosthesis and Other
Joint Prosthesis) Markets Independently Analyzed with Annual
Sales Figures in US$ Million for Years 2011 through 2015
(includes corresponding Graph/Chart) III-55

Table 77: uk Historic Review for Orthopedic Prosthetics by
Product Segment - Hip Prosthesis, Knee Prosthesis, and
Secondary Joint Prosthesis (Shoulder Prosthesis and Other
Joint Prosthesis) Markets Independently Analyzed with Annual
Sales Figures in US$ Million for Years 1995 through 2000
(includes corresponding Graph/Chart) III-55

Table 78: uk 15-Year Perspective for Orthopedic Prosthetics
by Product Segment - Percentage Breakdown of Value Sales for
Hip Prosthesis, Knee Prosthesis, and Secondary Joint
Prosthesis (Shoulder Prosthesis and Other Joint Prosthesis)
Markets for 1998, 2008,& 2012 (includes corresponding
Graph/Chart) III-56

4d. Italy III-57
A.Market Analysis III-57
Demographic Profile III-57
Table 79: Percentage Breakdown of Population by Age Group
in Italy (includes corresponding Graph/Chart) III-57
B.Market Analytics III-58
Table 80: Italian Recent Past, Current & Future Analysis for
Orthopedic Prosthetics by Product Segment -Hip Prosthesis,
Knee Prosthesis, and Secondary Joint Prosthesis (Shoulder
Prosthesis and Other Joint Prosthesis) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2001 through 2010 (includes corresponding Graph/Chart) III-58

Table 81: Italian Long-term Projections Orthopedic
Prostmetics by Product Segment -Hip Prosthesis, Knee
Prosthesis, and Secondary Joint Prosthesis (Shoulder
Prosthesis and Other Joint Prosthesis) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2011 through 2015 (includes corresponding Graph/Chart) III-58

Table 82: Italian Historic Review for Orthopedic Prosthetics
by Product Segment - Hip Prosthesis, Knee Prosthesis,and
Secondary Joint Prosthesis (Shoulder Prosthesis and Other
Joint Prosthesis) Markets Independently Analyzed with Annual
Sales Figures in US$ Million for Years 1995 through 2000
(includes corresponding Graph/Chart) III-59

Table 83: Italian 15-Year Perspective for Orthopedic
Prosthetics by Product Segment - Percentage Breakdown of
Value Sales for Hip Prosthesis, Knee Prosthesis, and
Secondary Joint Prosthesis (Shoulder Prosthesis and Other
Joint Prosthesis) Markets for 1998, 2008,& 2012 (includes
corresponding Graph/Chart) III-59

4e. Rest of Europe III-60
A.Market Analysis III-60
Overview of Select Markets in Europe III-60
Austria III-60
Czech Republic III-60
Spain III-61
Switzerland III-61
Ukraine III-61
Strategic Corporate Development III-62
B.Market Analytics III-62
Table 84: Rest of Europe Recent Past, Current & Future
Analysis for Orthopedic Prosthetics by Product Segment -Hip
Prosthesis, Knee Prosthesis, and Secondary Joint Prosthesis
(Shoulder Prosthesis and Other Joint Prosthesis) Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2001 through 2010 (includes corresponding
Graph/Chart) III-62

Table 85: Rest of Europe Long-term Projections Orthopedic
Prosthetics by Product Segment -Hip Prosthesis, Knee
Prosthesis, and Secondary Joint Prosthesis (Shoulder
Prosthesis and Other Joint Prosthesis) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2011 through 2015 (includes corresponding Graph/Chart) III-63

Table 86: Rest of Europe Market for Orthopedic Prosthetics -
Historic Review by Product Segment for Hip Prosthesis, Knee
Prosthesis, and Secondary Joint Prosthesis (Shoulder
Prosthesis and Other Joint Prosthesis) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
1995 through 2000 (includes corresponding Graph/Chart) III-63

Table 87: Rest of Europe 15-Year Perspective for Orthopedic
Prosthetics by Product Segment - Percentage Breakdown of
Value Sales for Hip Prosthesis, Knee Prosthesis, and
Secondary Joint Prosthesis (Shoulder Prosthesis and Other
Joint Prosthesis) Markets for 1998, 2008,& 2012 (includes
corresponding Graph/Chart) III-64

5. Asia-Pacific III-65
A.Market Analysis III-65
Factors Influencing Demand for Joint Replacement Procedures III-65
Hip Implants Market in Asia - Potential for Growth III-65
Declining Reimbursements - Means to Reduce Financial Burden III-65
Overview of Select Markets in Asia III-66
Australia III-66
China III-66
India III-66
Regulatory Impact on Orthopedic Devices Industry III-67
India - A Favored Destination for Low-Cost Orthopedic
Surgical Procedures III-67
New Zealand III-67
Government Funding for Increasing Number of Hip and Knee
Replacement Surgeries III-67
South Korea III-67
Imports III-68
Competition III-68
Table 88: Leading Players in the Korean Hip Implants
Market (2004): Percentage Breakdown by Value Sales for
Stryker, Zimmer, Depuy, and Others (includes
corresponding Graph/Chart) III-69

Table 89: Leading Players in the Korean Hip Implants
Market (2004): Percentage Breakdown by Value Sales for
Stryker, Zimmer, Depuy, and Others (includes
corresponding Graph/Chart) III-69
Taiwan III-69
Strategic Corporate Developments III-69
B.Market Analytics III-70
Table 90: Asia-Pacific Recent Past, Current & Future
Analysis for Orthopedic Prosthetics by Product Segment -Hip
Prosthesis, Knee Prosthesis, and Secondary Joint Prosthesis
(Shoulder Prosthesis and Other Joint Prosthesis) Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2001 through 2010 (includes corresponding
Graph/Chart) III-70

Table 91: Asia-Pacific Long-term Projections Orthopedic
Prosthetics by Product Segment -Hip Prosthesis, Knee
Prosthesis, and Secondary Joint Prosthesis (Shoulder
Prosthesis and Other Joint Prosthesis) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2011 through 2015 (includes corresponding Graph/Chart) III-70

Table 92: Asia-Pacific Market for Orthopedic Prosthetics -
Historic Review by Product Segment for Hip Prosthesis, Knee
Prosthesis, and Secondary Joint Prosthesis (Shoulder
Prosthesis and Other Joint Prosthesis) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
1995 through 2000 (includes corresponding Graph/Chart) III-71

Table 93: Asia-Pacific 15-Year Perspective for Orthopedic
Prosthetics by Product Segment - Percentage Breakdown of
Value Sales for Hip Prosthesis, Knee Prosthesis, and
Secondary Joint Prosthesis (Shoulder Prosthesis and Other
Joint Prosthesis) Markets for 1998, 2008,& 2012 (includes
corresponding Graph/Chart) III-71

6. Latin America III-72
Market Analysis III-72
Table 94: Latin American Recent Past, Current & Future
Analysis for Orthopedic Prosthetics by Product Segment -Hip
Prosthesis, Knee Prosthesis, and Secondary Joint Prosthesis
(Shoulder Prosthesis and Other Joint Prosthesis) Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2001 through 2010 (includes corresponding
Graph/Chart) III-72

Table 95: Latin American Long-term Projections Orthopedic
Prosthetics by Product Segment -Hip Prosthesis, Knee
Prosthesis, and Secondary Joint Prosthesis (Shoulder
Prosthesis and Other Joint Prosthesis) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2011 through 2015 (includes corresponding Graph/Chart) III-73

Table 96: Latin American Market for Orthopedic Prosthetics -
Historic Review by Product Segment for Hip Prosthesis, Knee
Prosthesis, and Secondary Joint Prosthesis (Shoulder
Prosthesis and Other Joint Prosthesis) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
1995 through 2000 (includes corresponding Graph/Chart) III-73

Table 97: Latin American 15-Year Perspective for Orthopedic
Prosthetics by Product Segment - Percentage Breakdown of
Dollar Sales for Hip Prosthesis, Knee Prosthesis, and
Secondary Joint Prosthesis (Shoulder Prosthesis and Other
Joint Prosthesis) Markets for 1998, 2008,& 2012 (includes
corresponding Graph/Chart) III-74

7. Rest of World III-75
A.Market Analysis III-75
Israel