7-ADCA Production & Market in China

7-ADCA Production & Market in China

AIM

? To outline the Chinese 7-ADCA industry from aspects of production, import & export.
? To summarize & introduce the Chinese 7-ADCA manufacturers
? To introduce the research situation on the above intermediates in China
? To evaluate the competitiveness of Chinese 7-ADCA industry
? To summarize the cephalosporin industry in brief

Scope

This project mainly researches 7-ADCA along the value chain, including
• Cefalexin
• Cefradine
• Cefaclor
• Cefadroxil
Highlights

China has begun the research on 7-ADCA since the Sixth Five-Year period (1980-1984). But for a long time, there was not commercial production due to lagged production route and low yield. China started commercial production of 7-ADCA in 1999. In the past years, the production of 7-ADCA was weak, and there are only 3 active manufacturers of 7-ADCA as of October 2003.

Chinese producers are not very optimistic about their future competitive ability because the production cost is high, and quite a large number of 7-ADCA consumers prefer imported 7-ADCA, whose price is lower than domestic product.

Some oversea pharmaceutical manufacturers, such as Italy Antibioticos and Netherlands Chemferm, have already set up joint ventures in China to engage in the production of cefradine, cefaclor, etc. These joint ventures possess quite a large share of cephalosporin market (about 35%), and they would like to use the imported 7-ADCA. The total import quantity of 7-ADCA is about 700 tonnes in China in 2001, of which 400 tonnes were imported by these two joint ventures.

Chinese production technology of 7-ADCA was not mature, and the cost for water and electricity is large.

The domestic supply of 7-ADCA can't meet the demand, and quite a large quantity of 7-ADCA needs to be imported. 7-ADCA has the largest import volume among all cephalosporin intermediates bulk pharmaceuticals. The import quantity of 7-ADCA in Jan 2003 occupied 44.92% of total imported cephalosporin intermediates bulk pharmaceuticals.



North China Pharmaceutical Co., Ltd. Beta Co., Ltd., Guangzhou Prospro Fine Chemical Co., Ltd., Shandong Lukang Pharmaceutical Group Luyuan Co., Ltd., Sichuan Pharmaceutical Co., Ltd.

TABLE OF CONTENTS
1. Introduction
2. Methodology & Sources
3. Glossary
4. Executive Summary
6. Siutation of 7-ADCA
6.1 Production Situation of 7-ADCA in the Past Years
6.2 Import & Export Analysis of 7-ADCA in 2001
6.2.1 Import Situation –Breakdown by Origin
6.2.2 Import Situation – Breakdown by Importers
6.2.3 Export Situation
6.3 Brief Summary on Downstream Products of 7-ADCA
6.3.1 Cefalexin
6.3.2 Cefradine
6.3.3 Cefaclor
6.3.4 Cefadroxil
6.4 Information of Raw Materials for 7-ADCA
6.5 Research Situation of 7-ADCA in China
6.5.1 Flowchart of 7-ADCA
6.5.2 Production Method of 7-ADCA & Active Researchers in China
6.6 Manufacturers of 7-ADCA
6.6.1 North China Pharmaceutical Co., Ltd. Beta Co., Ltd.
……….
6.6.4 Manufacturers who Stopped Production:
7. Mass Balance of 7-ACA & 7-ADCA in 2000
8. Government Management on the Production of 7-ACA & 7-ADCA in China
9. Conclusion & Recommendation

LIST OF TABLES
Table 6.1-1 Summary of 7-ADCA in China
Table 1. List of 7-ADCA manufacturers in China
Table 2. Production Situation 7-ADCA in China
Table 6.2.1-1 Origins of imported 7-ADCA in 2001
Table 6.2.2-1 Importers of 7-ADCA in 2001
Table 3.7-ADCA Import Analysis in 2002 - by major Importers
Table 4.7-ADCA Import Analysis in 2002 - by Origin country
Table 5. Production Situation of major 7-ADCA derivatives in China (MTs/year)
Table 6.3.1-1 The production of cefalexin in the past years (Unit: MT)
Table 6.3.1-2 The import & export of cephalexin in the past years
Table 6.3.1-3 The production of cefalexin in the past years (Unit: MT)
Table 6.3.1-4 Manufacturers of cefalexin in China (Unit: MT)-year 2000
Table 6.3.1-5 Manufacturers of cefalexin in China (Unit: MT)-year 2002
Table 6.3.1-6 The import & export of cephalexin in the past years
Table 6.3.2-1 The production of cefradine in the past years (Unit: MT)
Table 6.3.2-2 The import & export of cefradine in the past years
Table 6.3.2-3 The production of cefradine in the past years (Unit: MT)
Table 6.3.2-4 The import & export of cefradine in the past years
Table 6.3.2-5 Manufacturers of cefradine in China (Unit: MT) -year 2000
Table 6.3.2-6 Manufacturers of cefradine in China (Unit: MT)-year 2002
Table 6.3.3-1 The import & export of cefaclor in the past years
Table 6.3.3-2 The import & export of cefaclor in the past years
Table 6.3.4-1 The production of cefadroxil in the past years (Unit: MT)
Table 6.3.4-2 The production of cefadroxil in the past years (Unit: MT)
Table 6.3.4-3 Manufacturers of cefadroxil in China (Unit: MT)-year 2002

LIST OF FIGURES
Flowchart of 7-ADCA