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Brain Tumor - Pipeline Review, H2 2014

  • July 2014
  • -
  • Global Markets Direct
  • -
  • 90 pages

Brain Tumor - Pipeline Review, H2 2014

Summary

Global Markets Direct’s, ‘Brain Tumor - Pipeline Review, H2 2014’, provides an overview of the Brain Tumor’s therapeutic pipeline.

This report provides comprehensive information on the therapeutic development for Brain Tumor, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Brain Tumor and special features on late-stage and discontinued projects.

Global Markets Direct’s report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct’s proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct’s team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis.

The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products.

Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease.

Scope

- The report provides a snapshot of the global therapeutic landscape of Brain Tumor
- The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities
- The report reviews key players involved in the therapeutics development for Brain Tumor and enlists all their major and minor projects
- The report summarizes all the dormant and discontinued pipeline projects
- A review of the Brain Tumor products under development by companies and universities/research institutes based on information derived from company and industry-specific sources
- Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages
- A detailed assessment of monotherapy and combination therapy pipeline projects
- Coverage of the Brain Tumor pipeline on the basis of target, MoA, route of administration and molecule type
- Latest news and deals relating related to pipeline products

Reasons to buy

- Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies
- Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
- Develop strategic initiatives by understanding the focus areas of leading companies
- Identify and understand important and diverse types of therapeutics under development for Brain Tumor
- Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline
- Devise corrective measures for pipeline projects by understanding Brain Tumor pipeline depth and focus of Indication therapeutics
- Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope
- Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline

Table Of Contents

Brain Tumor - Pipeline Review, H2 2014
Table of Contents
Table of Contents 2
List of Tables 5
List of Figures 6
Introduction 7
Global Markets Direct Report Coverage 7
Brain Tumor Overview 8
Therapeutics Development 9
Pipeline Products for Brain Tumor - Overview 9
Pipeline Products for Brain Tumor - Comparative Analysis 10
Brain Tumor - Therapeutics under Development by Companies 11
Brain Tumor - Therapeutics under Investigation by Universities/Institutes 13
Brain Tumor - Pipeline Products Glance 14
Clinical Stage Products 14
Early Stage Products 15
Brain Tumor - Products under Development by Companies 16
Brain Tumor - Products under Investigation by Universities/Institutes 17
Brain Tumor - Companies Involved in Therapeutics Development 18
Chong Kun Dang Pharmaceutical Corp. 18
Pfizer Inc. 19
Bayer AG 20
Nanobiotix 21
Hutchison MediPharma Limited 22
Siena Biotech S.p.A. 23
Oncovir, Inc. 24
DEKK-TEC, Inc. 25
SignPath Pharma Inc 26
CalAsia Pharmaceuticals, Inc. 27
Brain Tumor - Therapeutics Assessment 28
Assessment by Monotherapy Products 28
Assessment by Combination Products 29
Assessment by Target 30
Assessment by Mechanism of Action 33
Assessment by Route of Administration 36
Assessment by Molecule Type 38
Drug Profiles 40
DM-CHOC-PEN - Drug Profile 40
Product Description 40
Mechanism of Action 40
RandD Progress 40
beloranib - Drug Profile 41
Product Description 41
Mechanism of Action 41
RandD Progress 41
Poly-ICLC - Drug Profile 44
Product Description 44
Mechanism of Action 44
RandD Progress 44
GliAtak - Drug Profile 46
Product Description 46
Mechanism of Action 46
RandD Progress 46
indoximod - Drug Profile 47
Product Description 47
Mechanism of Action 47
RandD Progress 47
dianhydrogalactitol - Drug Profile 49
Product Description 49
Mechanism of Action 49
RandD Progress 49
HMPL-813 - Drug Profile 51
Product Description 51
Mechanism of Action 51
RandD Progress 51
DC/AAT + DC/AAT-Flu + DC/KLH - Drug Profile 52
Product Description 52
Mechanism of Action 52
RandD Progress 52
CIGB-128 - Drug Profile 53
Product Description 53
Mechanism of Action 53
RandD Progress 53
Cell Therapy for Brain Cancer - Drug Profile 55
Product Description 55
Mechanism of Action 55
RandD Progress 55
HOOI - Drug Profile 56
Product Description 56
Mechanism of Action 56
RandD Progress 56
Tankyrase/Wnt Inhibitors - Drug Profile 57
Product Description 57
Mechanism of Action 57
RandD Progress 57
Bispecific Antibody for Brain Tumor - Drug Profile 58
Product Description 58
Mechanism of Action 58
RandD Progress 58
Bay-846 - Drug Profile 59
Product Description 59
Mechanism of Action 59
RandD Progress 59
NBTX-TOPO - Drug Profile 60
Product Description 60
Mechanism of Action 60
RandD Progress 60
VO-100 - Drug Profile 61
Product Description 61
Mechanism of Action 61
RandD Progress 61
PF-06463922 - Drug Profile 62
Product Description 62
Mechanism of Action 62
RandD Progress 62
Small Molecules to Inhibit Hsp90 Alpha and TRAP1 for Brain Cancer - Drug Profile 64
Product Description 64
Mechanism of Action 64
RandD Progress 64
Polymeric Nanocurcumin - Drug Profile 65
Product Description 65
Mechanism of Action 65
RandD Progress 65
Monoclonal Antibody to Inhibit EGFR for Brain Tumor - Drug Profile 67
Product Description 67
Mechanism of Action 67
RandD Progress 67
Brain Tumor - Recent Pipeline Updates 68
Brain Tumor - Dormant Projects 79
Brain Tumor - Discontinued Products 80
Brain Tumor - Product Development Milestones 81
Featured News and Press Releases 81
May 20, 2014: Oncolytics Biotech Collaborators to Present Positive Brain Cancer Clinical Trial Data at the 50th Annual ASCO Meeting 81
Dec 16, 2013: Angiochem Demonstrates Peptide Antibody Conjugate That Successfully Crosses the Blood Brain Barrier and Increases Survival in HER-2 Positive Brain Tumors 81
Nov 16, 2013: Burzynski Clinic Presents Over Five Years Survival Data From Phase II Trials of ANP for Inoperable Brain Tumors at the Congress 82
Mar 18, 2013: Anti-nausea Drug Halts Growth Of Brain Tumors, Research Finds 82
Dec 17, 2012: new immune therapy successfully treats brain tumors in mice 83
Aug 18, 2011: Cell Therapeutics Announces Enrollment Of Phase II Study Of OPAXIO In Combination With Temozolomide And Radiotherapy In Brain Tumors 84
Jun 06, 2011: CTI Announces Interim Results Of Phase II Study Of OPAXIO In Combination With Temozolomide And Radiotherapy In Brain Tumors 85
Feb 02, 2011: Antisense Pharma Receives Approval For Clinical Studies In South Korea And Taiwan In Malignant Brain Tumors 85
Nov 02, 2010: Antisense Pharma's Trabedersen In Malignant Brain Tumors: Phase IIb Data Published In Neuro-Oncology 86
Oct 29, 2010: Novartis Drug Afinitor Approved by FDA as First Medication for Children and Adults with a Benign Brain Tumor Associated with Tuberous Sclerosis. 87
Appendix 89
Methodology 89
Coverage 89
Secondary Research 89
Primary Research 89
Expert Panel Validation 89
Contact Us 90
Disclaimer 90

List of Tables

Number of Products under Development for Brain Tumor, H2 2014 9
Number of Products under Development for Brain Tumor - Comparative Analysis, H2 2014 10
Number of Products under Development by Companies, H2 2014 12
Number of Products under Investigation by Universities/Institutes, H2 2014 13
Comparative Analysis by Clinical Stage Development, H2 2014 14
Comparative Analysis by Early Stage Development, H2 2014 15
Products under Development by Companies, H2 2014 16
Products under Investigation by Universities/Institutes, H2 2014 17
Brain Tumor - Pipeline by Chong Kun Dang Pharmaceutical Corp., H2 2014 18
Brain Tumor - Pipeline by Pfizer Inc., H2 2014 19
Brain Tumor - Pipeline by Bayer AG, H2 2014 20
Brain Tumor - Pipeline by Nanobiotix, H2 2014 21
Brain Tumor - Pipeline by Hutchison MediPharma Limited, H2 2014 22
Brain Tumor - Pipeline by Siena Biotech S.p.A., H2 2014 23
Brain Tumor - Pipeline by Oncovir, Inc., H2 2014 24
Brain Tumor - Pipeline by DEKK-TEC, Inc., H2 2014 25
Brain Tumor - Pipeline by SignPath Pharma Inc, H2 2014 26
Brain Tumor - Pipeline by CalAsia Pharmaceuticals, Inc., H2 2014 27
Assessment by Monotherapy Products, H2 2014 28
Assessment by Combination Products, H2 2014 29
Number of Products by Stage and Target, H2 2014 32
Number of Products by Stage and Mechanism of Action, H2 2014 35
Number of Products by Stage and Route of Administration, H2 2014 37
Number of Products by Stage and Molecule Type, H2 2014 39
Brain Tumor Therapeutics - Recent Pipeline Updates, H2 2014 68
Brain Tumor - Dormant Projects, H2 2014 79
Brain Tumor - Discontinued Products, H2 2014 80

List of Figures

Number of Products under Development for Brain Tumor, H2 2014 9
Number of Products under Development for Brain Tumor - Comparative Analysis, H2 2014 10
Number of Products under Development by Companies, H2 2014 11
Number of Products under Investigation by Universities/Institutes, H2 2014 13
Comparative Analysis by Clinical Stage Development, H2 2014 14
Comparative Analysis by Early Stage Products, H2 2014 15
Assessment by Monotherapy Products, H2 2014 28
Number of Products by Top 10 Target, H2 2014 30
Number of Products by Stage and Top 10 Target, H2 2014 31
Number of Products by Top 10 Mechanism of Action, H2 2014 33
Number of Products by Stage and Top 10 Mechanism of Action, H2 2014 34
Number of Products by Top 10 Route of Administration, H2 2014 36
Number of Products by Stage and Top 10 Route of Administration, H2 2014 37
Number of Products by Top 10 Molecule Type, H2 2014 38
Number of Products by Stage and Top 10 Molecule Type, H2 2014 39

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