Electrical and magnetic stimulation is theprimary focus of this Kalorama Information Report. Rather than attempting todefine and classify all of the varying electrostimulatory methods, this reportgroups technologies into basic categories based on application and complexity.

The audience for this report includestechnical directors, business development managers, investors, and analysts whowant a panoramic view, at a quantitative level, of the technology and medicalapplications of electrical and magnetic stimulation. This is a far-reachingfield, and this report thus serves as a survey aimed at providing insight aboutthe realm of market possibilities. Two general segments are discussed withvarious sub-segments included:


External ElectricalStimulation Devices:



  • Bone Growth Simulation

  • Transcutaneous ElectricalNerve Stimulation (TENS)

  • Ultrasound-AcceleratedFracture Healing


Implanted Electrical Simulation Devices

  • Bone Growth Stimulation

  • Cardiac ResynchronizationTherapy

  • Deep Brain Stimulation

  • Gastric Electrical Stimulation

  • Implantable Cardiac Pacemakers

  • ImplantableCardioverter-Defibrillators

  • Sacral Nerve Stimulation

  • Spinal Cord Stimulation

  • Vagus Nerve Stimulation


Companies involved in the market areprofiled to provide an understanding of today’s competitive environment andmarketing strategies.

Demand for both electrical and magnetic neurostimulationtechnologies is expected to grow moderately during the next few years.


TENS is commonly used for pain management.Despite controversy over the degree to which TENS is more effective thanplacebo in reducing pain, the market for TENS equipment continues to remain steady. Electromuscular stimulation (EMS) of muscle tissue can aid in the recuperation ofoverworked muscles. Technological progress continues in EMS,especially with microprocessors that allow protection against the risk ofburning and elimination of electrical pain. Transcranial magnetic stimulation (TMS) isa non-invasive technique that uses an electromagnet placed on the patient’sscalp to alter brain activity. Repetitive TMS (rTMS), which uses varyingfrequencies and intensities of magnetic fields, seems to have therapeuticvalue. During the previous years, rTMS has received a growing attention in thepopular and scientific media. The market forecasts reflect growing professionalmedical acceptance. The demand of electrostimulation productsbased on external electrodes is expected to benefit from innovativedevelopments in FES designed to augmentmovement of atrophied muscles, promote new nerve function, and provideinterfaces between nerve cells and computing devices. The market for treating depression is oneof the most promising applications of neurotechnology devices. The potentialmarket opportunity is huge, with between over 20 million people in the U.S.alone who could potentially benefit.


A new group of active electrodes are underdevelopment. These can connect nerve cells to microcircuits and provide aliving link between living tissues and hardware. Direct interfaces betweensmall networks of nerve cells and microdevices are advancing the understandingof nerves and leading the way to a new generation of hybrid devices thatcommunicate between computers and biological neural networks. There are severalresearch teams in the U.S.and Europe that are currently working onso-called neural-silicon hybrid chips. Wireless technology could lead to the replacementof leads with small radios that can transmit and receive information andenergy.


Table Of Contents

CHAPTER ONE: EXECUTIVE SUMMARY


  • Electrostimulation and Neuroprosthetic Technology Introduction

    andnbsp;



  • Scope of This Report

    andnbsp;



  • A Strong Market Foundation

    andnbsp;



  • Future Directions

    andnbsp;



  • Market Size and Projections

    andnbsp;




CHAPTER TWO: INTRODUCTION TO ELECTROSTIMULATION AND RELATED TECHNOLOGIES

  • Stimulation Therapeutics for Muscles and Nerves

    andnbsp;



  • Medical Applications of External Electrode Modalities

    • Electrical Stimulation

      andnbsp;



    • Measurement and Diagnosis

      andnbsp;



    • Stimulation by Magnetic Field Pulses

      andnbsp;



    • Ultrasonic and Short Wavelength Diathermy

      andnbsp;




    andnbsp;



  • Medical Applications of Implanted Electrode Modalities

    • Bladder Stimulators

      andnbsp;



    • Carotid Sinus Nerve Stimulation

      andnbsp;



    • Cochlear Implant

      andnbsp;



    • Deep Brain Stimulation

      andnbsp;



    • Electrical Continence

      andnbsp;



    • Electrical Nerve Stimulation

      andnbsp;



    • Pelvic Floor Stimulation

      andnbsp;



    • Phrenic Nerve Stimulation

      andnbsp;



    • Sacral Nerve Stimulation

      andnbsp;



    • Spinal Cord Stimulation

      andnbsp;



    • Vagus Nerve Stimulation

      andnbsp;




    andnbsp;



  • Characteristics of the Electrostimulation Market

    • Market Segmentation of Neurostimulation Modalities

      andnbsp;




    andnbsp;



  • Market Trends and Assumptions

    andnbsp;



  • Competitive Landscape and Issues

    • Applicable Industrial and Regulatory Codes

      andnbsp;



    • Companies in the Electrostimulation Market

      andnbsp;




    andnbsp;



  • End-User Segments

    andnbsp;




CHAPTER THREE : EXTERNAL ELECTRICAL STIMULATION DEVICES

  • Introduction

    andnbsp;



  • External Electrostimulation Technologies

    andnbsp;



  • Bone Growth Stimulation

    • Market Analysis

      andnbsp;




    andnbsp;



  • EMS, NMS, TENS

    • Transcutaneous Electrical Nerve Stimulation (TENS)

      andnbsp;



    • Early Observations of Pain Relief

      andnbsp;



    • Physiological Model Theories

      andnbsp;



    • Interferential Current

      andnbsp;



    • Galvanic Stimulation

      andnbsp;



    • Electrodes

      andnbsp;



    • Market Analysis

      andnbsp;




    andnbsp;



  • Ultrasound-Accelerated Fracture Healing

    • Market Analysis

      andnbsp;




    andnbsp;



  • Other Treatments

    • ECT

      andnbsp;



    • TMS and rTMS

      andnbsp;




    andnbsp;



  • Market Forecasts for Electrostimulation With External Electrodes

    andnbsp;




CHAPTER FOUR: IMPLANTED ELECTRICAL AND NEUROLOGICAL STIMULATION DEVICES

  • Introduction

    andnbsp;



  • Types of Implanted Electrode Systems

    andnbsp;



  • Implanted Bone Growth Stimulators

    • Market Analysis

      andnbsp;




    andnbsp;



  • Cardiac Rhythm Management

    • Cardiac Resynchronization Therapy

      andnbsp;



    • Implantable Cardiac Pacemakers

      andnbsp;



    • Implantable Cardioverter-Defibrillators

      andnbsp;



    • Market Analysis

      andnbsp;




    andnbsp;



  • Spinal Cord Stimulation (SCS)

    • Basic Implementation

      andnbsp;



    • SCS vs TENS in Pain Relief

      andnbsp;



    • Cost-Benefit Analysis of SCS

      andnbsp;



    • Market Analysis

      andnbsp;




    andnbsp;



  • Sacral Nerve Stimulation (SNS)

    • Control of Urinary Incontinence

      andnbsp;



    • Control of Fecal Incontinence

      andnbsp;



    • Market Analysis

      andnbsp;




    andnbsp;



  • Vagus Nerve Stimulation (VNS)

    • Seizure Control in Epilepsy

      andnbsp;



    • Treatment of Depression

      andnbsp;



    • Market Analysis

      andnbsp;




    andnbsp;



  • Deep Brain Stimulation (DBS)

    • Treatment of Neurological Movement Disorders

      andnbsp;



    • Market Analysis

      andnbsp;




    andnbsp;



  • Gastric Electrical Stimulation (GES)

    • Market Analysis

      andnbsp;




    andnbsp;



  • Market Analysis for Implanted Electrical and Neurological Stimulation Devices

    andnbsp;




CHAPTER FIVE: INDUSTRY TRENDS AND ISSUES

  • New Innovations

    • Brain Stimulation

      andnbsp;



    • Obstructive Sleep Apnea

      andnbsp;



    • Neurostim and Obesity

      andnbsp;



    • Implantable Therapy for Resistant Hypertension

      andnbsp;



    • Pain Therapy

      andnbsp;



    • Epilepsy

      andnbsp;




    andnbsp;



  • New Developments and Alternative Technologies

    • Magnetic Stimulation

      andnbsp;



    • Transcranial Magnetic Stimulation (TMS)

      andnbsp;



    • Magnetic Stimulation and Depression Treatment

      andnbsp;



    • Magnetic Stimulation and Neurological Trauma Therapy

      andnbsp;



    • Magnetic Stimulation and Auditory Hallucinations

      andnbsp;



    • Magnetic Stimulation and the Effects on Cerebral Blood Flow

      andnbsp;



    • TMS Potential

      andnbsp;



    • TMS/rTMS Instrument Parameters

      andnbsp;



    • Neuroprosthetics

      andnbsp;



    • Functional Electrical Stimulation (FES)

      andnbsp;



    • Bidirectional Neuroprotheses

      andnbsp;



    • Cochlear Implants

      andnbsp;



    • Retinal Implants

      andnbsp;



    • Neurostimulation for Depression

      andnbsp;



    • The Neuron-Silicon Interface

      andnbsp;



    • Physiology of EMS Applications

      • Endurance Training by Increased Oxygen Supply

        andnbsp;



      • Muscle Recovery via Increased Blood Flow

        andnbsp;




      andnbsp;



    • Muscle Diagnostics with Electromyography

      andnbsp;



    • Uncertainties in Electrostimulation Business Development Management

      andnbsp;



    • Future advancements

      andnbsp;



    • New technology challenges




CHAPTER SIX: MARKET SUMMARY

  • Total Market Overview

    andnbsp;



  • Geographical Market Analysis


andnbsp;



    CHAPTER SEVEN: COMPANY PROFILES






      LIST OF EXHIBITS

      andnbsp;


      CHAPTER ONE: EXECUTIVE SUMMARY



      • Summary Table: Electrical and Neurostimulation Equipment/Device Market by Application Method, 2010-2017

        andnbsp;



      • Summary Figure: Electrical and Neurostimulation Equipment/Device Market by Application Method, 2010-2017

        andnbsp;




      CHAPTER TWO: INTRODUCTION TO ELECTROSTIMULATION AND RELATED TECHNOLOGIES

      • Table 2-1: Energy/Radiation Stimulation Medical Electronics Products

        andnbsp;



      • Table 2-2: Implanted Electrode Stimulation Technologies

        andnbsp;



      • Table 2-3: Market Drivers Impacting Electrostimulation Equipment Sales

        andnbsp;



      • Table 2-4: Market Restraints Limiting Electrostimulation Equipment Sales

        andnbsp;



      • Table 2-5: Standard Industrial Codes (SIC) for Electrical/Magnetic Stimulation Equipment

        andnbsp;



      • Table 2-6: North American Industry Classification System (NAICS) Codes for Electrical/Magnetic Stimulation Equipment

        andnbsp;



      • Table 2-7: Major Players by Segment, 2012

        andnbsp;



      • Table 2-8: US Healthcare Practitioners by Occupation Title, 2010

        andnbsp;




      CHAPTER THREE: EXTERNAL ELECTRICAL STIMULATION DEVICES

      • Table 3-1: Electrode Stimulation Modalities with External Electrodes Type and Description

        andnbsp;



      • Table 3-2The World Market for External Bone Growth Stimulation Devices 2010-2017

        andnbsp;



      • Figure 3-1: The World Market for External Bone Growth Stimulation Devices 2010-2017

        andnbsp;



      • Table 3-3: TENS and EMS Stimulation Modes

        andnbsp;



      • Table 3-4: The World Market for TENS and EMS Devices 2010-2017

        andnbsp;



      • Figure 3-2: The World Market for TENS and EMS Devices 2010-2017

        andnbsp;



      • Table 3-5: The World Market for Ultrasound-Accelerated Fracture Healing Systems 2010-2017

        andnbsp;



      • Figure 3-3: The World Market for Ultrasound-Accelerated Fracture Healing Systems 2010-2017

        andnbsp;



      • Table 3-6: The World Market for Other External Electrostimulation Devices 2010-2017

        andnbsp;



      • Figure 3-4: The World Market for Other External Electrostimulation Devices 2010-2017

        andnbsp;



      • Table 3-7: External Electrostimulation Device Market by Product Type 2010-2017

        andnbsp;



      • Figure 3-5: External Electrostimulation Device Market by Product Type 2010-2017

        andnbsp;



      • Figure 3-6: External Electrostimulation Device Market by Product Type 2012 and 2017

        andnbsp;




      CHAPTER FOUR: IMPLANTED ELECTRICAL AND NEUROLOGICAL STIMULATION DEVICES

      • Table 4-1: The World Market for Implantable Bone Growth Stimulation Devices 2010-2017

        andnbsp;



      • Figure 4-1: The World Market for Implantable Bone Growth Stimulation Devices 2010-2017

        andnbsp;



      • Table 4-2: The World Market for Implantable Cardiac Rhythm Management Devices 2010-2017

        andnbsp;



      • Figure 4-1: The World Market for Implantable Cardiac Rhythm Management Devices 2010-2017

        andnbsp;



      • Table 4-3: The World Market for Spinal Cord Stimulation Devices 2010-2017

        andnbsp;



      • Figure 4-2: The World Market for Spinal Cord Stimulation Devices 2010-2017

        andnbsp;



      • Table 4-4: The World Market for Sacral Nerve Stimulation Devices 2010-2017

        andnbsp;



      • Figure 4-3: The World Market for Sacral Nerve Stimulation Devices 2010-2017

        andnbsp;



      • Table 4-5: The World Market for Vagus Nerve Stimulation Devices 2010-2017

        andnbsp;



      • Figure 4-4: The World Market for Vagus Nerve Stimulation Devices 2010-2017

        andnbsp;



      • Table 4-6: The World Market for Deep Brain Stimulation Devices 2010-2017

        andnbsp;



      • Figure 4-5: The World Market for Deep Brain Stimulation Devices 2010-2017

        andnbsp;



      • Table 4-7: The World Market for Gastric Electrical Stimulation Devices 2010-2017

        andnbsp;



      • Figure 4-6: The World Market for Gastric Electrical Stimulation Devices 2010-2017

        andnbsp;



      • Table 4-8: Implantable Electrical and Neurological Stimulation Market by Product Segment 2010-2017

        andnbsp;



      • Figure 4-7: Implantable Electrical and Neurological Stimulation Market by Product Segment 2010-2017

        andnbsp;



      • Figure 4-8: Implantable Electrical and Neurological Stimulation Market by Product Segment 2012 and 2017

        andnbsp;




      CHAPTER SIX: MARKET SUMMARY

      • Table 6-1: Electrical and Neurostimulation Equipment/Device Market by Application Method, 2010-2017

        andnbsp;



      • Figure 6-1: Electrical and Neurostimulation Equipment/Device Market by Application Method, 2010-2017

        andnbsp;



      • Figure 6-2: Electrical and Neurostimulation Equipment/Device Market by Application Method, 2012 and 2017

        andnbsp;



      • Table 6-2: Electrical and Neurostimulation Equipment/Device Market Estimated Sales by Geographic Region 2010-2017

        andnbsp;



      • Figure 6-4: Electrical and Neurostimulation Equipment/Device Market Estimated Sales by Geographic Region 2010-2017

        andnbsp;



      • Figure 6-5: Electrical and Neurostimulation Equipment/Device Market Estimated Sales by Geographic Region 2012 and 2017

        andnbsp;




      andnbsp;



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