Microarray Markets

Microarray Markets

A microarray is an arrangement of miniaturized test sites or “spots” on a surface. Each spot is usually no more than 250 micrometers in diameter and contains biological molecules—usually DNA or protein—which act as probes for a test sample applied to the array. The surface may be a glass slide, a plastic plate with wells or a polymer bead. The microarray format allows many tests or experiments to be performed simultaneously, in parallel, leading to the generation of huge amounts of biological information for the application of only a tiny amount of sample.

Microarrays are often also known as “biochips”. The purpose of this TriMark Publications report is to describe the specific segment of the microarray market aimed at analysis of proteins and DNA. Protein microarray applications include: 1) expression profiling; 2) serum-based diagnostics; 3) protein-protein binding assays; 4 drug-target binding; and 5) receptor epitope binding. It examines the market for DNA and protein array testing equipment and supplies using screening reagents and instruments for analysis of individual components in blood, serum or plasma.

It defines the dollar volume of sales, both worldwide and in the U.S., and analyzes the factors that influence the size and the growth of the market segments. Also examined are the subsections of each market segment, including the research labs, hospital labs, and commercial laboratories. Additionally, the numbers of institutions using this type of testing and the factors that influence purchases are discussed. The report surveys almost all of the companies known to be marketing, manufacturing or developing instruments and reagents for the protein array market in the U.S. Each company is discussed in depth with a section on its history, product line, business and marketing analysis, and a subjective commentary of the company’s market position. 
 

1. Overview

1.1 Statement of Report

1.2 About This Report

1.3 Scope of the Report

1.4 Objectives

1.5 Methodology

1.6 Executive Summary

2. Overview of Microarrays

2.1 History of Microarrays

2.2 Genomics and Proteomics

2.2.1 Genetic Variability and Disease

2.3 General Theory of Microarrays

2.4 DNA Microarrays

2.5 Protein Microarrays

2.6 Tissue Microarrays

3. DNA Microarrays

3.1 Advantages and Drivers

3.2 Limitations and Barriers to Commercialization

3.3 DNA Microarray Technology Platforms

3.3.1 Reasons Why Researchers Utilize DNA Microarrays

3.3.2 Factors for Difficulties Applying DNA Microarrays Technology

3.4 Key Attributes of DNA Microarray Software

3.5 Applications

3.6 Future Directions for DNA Microarray Technology

3.6.1 High-Throughput Array Technology

3.6.2 Emerging Microarray Trends

3.6.3 Emerging Microarray Applications

3.6.4 Key Points for Developing Microarray Based Applications

3.7 Competitive Landscape for DNA Microarrays

4. Protein Microarrays

4.1 Critical Factors for Microarray Content

4.2 Key Findings on Use of Microarrays

4.3 Advantages and Drivers

4.4 Limitations and Barriers to Commercialization

4.5 Key Experimental Parameters of Protein Microarray Technology for Current and Future Users

4.6 Reasons Why Researchers Utilize Protein Microarrays

4.7 Factors for Adoption of Protein Microarrays Technology

4.8 Top Suppliers of Protein Microarray Slides and Products

4.9 Factors that Influence Sale Decisions

4.10 Future Innovations in Protein Microarray Technology

5. Current DNA Microarrays

5.1 Key Players

5.2.1 Microarray-Based Commercial Genotyping Activity

5.2.2 Location Analysis

5.3 Future Innovations in DNA Microarray Technology

6. Current Protein Microarrays

6.1 Protein Profiling Microarrays—Antibody Arrays

6.2 Protein Profiling Microarrays—Reverse Phase Microarrays

6.3 Multiplex Sandwich Microarrays—Planar

6.4 Multiplex Sandwich Immunoassays—Bead Based

6.5 Microarrays for Protein Function Studies

6.6 High Growth Applications

6.6.1 Cytokine Arrays

6.6.2 Whole Proteome Arrays

6.6.3 Microarray-Based Commercial Genotyping Activity

6.6.3.1 Microarray-Based Genotyping Applications

6.6.3.2 Microbial Applications

6.6.3.3 The Market for Microbial Genotyping Products

6.6.3.4 Comparative Genomic Hybridization (CGH)

6.6.4 ChIP-on-Chip Analysis

7. Technology

7.1 Production of Microarrays

7.2 2-D Versus 3-D Technology

7.3 Substrates and Surface Chemistries

7.4 Detection Methods

7.5 Instruments

7.6 Data Management and Informatics in Gene Expression

8. Applications

8.1 DNA Microarrays in Gene Expression

8.2 DNA Microarrays in SNP Analysis

8.3 DNA Microarrays in Cancer

8.4 Protein Expression

8.4.1 Cytokine Applications

8.4.2 Protein Function

8.4.3 Protein-Protein Interactions

8.5 Target /Biomarker Discovery

8.6 Drug Discovery and Development (Gene and Protein Microarrays)

8.7 Clinical Diagnostics (Gene and Protein Microarrays)

8.8 RNA Microarrays

8.9 Oligo Microarrays

8.10 Yeast Microarrays

8.11 Antibody Arrays

8.12 Arrays for Toxicogenomics

9. The Commercial Opportunity for Microarrays

9.1 Market Drivers for Microarrays

9.2 Market Restraints for Microarrays

9.3 Key Players

9.4 Market Size, Strategic Trends and Competitive Landscape for Protein Arrays

9.5 Marketing and Distribution

9.6 Protein Arrays Market Analysis

9.7 Genes Associated with Major Diseases

9.8 Software and Data Analysis

9.8.1 Supplier of DNA Microarray Analysis Software

9.8.2 Satisfaction with Software Features

9.8.3 Satisfaction with Software

9.8.4 Supplier Factors in Software Purchase Decision

9.8.5 Suppliers’ Role in Improving Data Sharing for DNA Microarrays

10. Company Profiles

10.1 Manufacturers

LIST OF FIGURES

Figure 6.1: Cytokines and Growth Factors: Sources of Microarrays for Cytokine Research

Figure 8.1: Microbial Genotyping: Applications for DNA Microarrays

Figure 8.2: Source of Variation in Microarray Data

Figure 8.3: Toxicogenomics: DNA Microarrays

LIST OF TABLES

Table 3.1: Microarray Product Revenue: Arrays, Reagents and Instruments, 2005 and 2010

Table 3.2: Microarray Market Drivers

Table 3.3: Microarray Market Barriers

Table 3.4: Unit Pricing of DNA Microarrays, 2000-2010

Table 3.5: Steps in the Design and Implementation of a DNA Microarray Experiment

Table 3.6: Microarray Applications

Table 3.7: List of DNA Array Manufacturers

Table 4.1: Critical Factors for Microarray Content

Table 4.2: Top Three Suppliers of Treated Protein Microarray Surfaces for Self-Printing

Table 4.3: Top Suppliers of Commercially Available Protein Microarrays

Table 4.4: Top Suppliers of Protein Microarray Readers

Table 5.1: Affymetrix Sales of Probe Arrays, 2000-2007

Table 5.2: Affymetrix Total Product Sales, 1999-2007

Table 5.3: Affymetrix Instrument Sales, 2000-2007

Table 6.1: Microarray Genetic Testing

Table 6.2: ChIP-on-Chip Microarray Market Size Projections, 2005-2011

Table 8.1: Applications of Biochips by Class

Table 8.2: Diagnostics Microarray Market Size Projections, 2005-2011

Table 8.3: HTS Microarray Market Size Projections, 2005-2011

Table 8.4: Pharmacogenomics Microarray Market Size Projections, 2005-2011

Table 8.5: Toxicology Screening Microarray Market Size Projections, 2005-2011

Table 8.6: Expression Profiling Microarray Market Size Projections, 2005-2011

Table 9.1: Market Share of Microarray Products, 2006

Table 9.2: Affymetrix Product Sales

Table 9.3: Leading Microarray Companies

Table 9.4: Worldwide Microarray Market Size, 2004-2012

Table 9.5: Microarray Market Share by Technology Type

Table 9.6: DNA Microarray U.S. Market Size, 2005-2011

Table 9.7: DNA Microarray Worldwide Market Size, 2002-2011

Table 9.8: Biochip Market by Usage, 2003 and 2007