Nanostructured Materials for the Biomedical, Pharmaceutical, and Cosmetic Markets

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Nanostructured Materials for the Biomedical, Pharmaceutical, and Cosmetic Markets

Nanostructured Materials for the Biomedical, Pharmaceutical, and Cosmetic Markets

Report price : $ 4 850
Publication date : November 2007

Nanostructured Materials for the Biomedical, Pharmaceutical, and Cosmetic Markets

This report contains: Descriptions of various types of nanoparticles including nanoparticulate ceramics, metals, alloys, and semiconductors in the form of dry powders, liquid dispersions, coatings and bulk materials; The current market status for nanoparticles, trends and forecasts for growth over the next 5 years; Discussion of organic nanoparticles such as lipids and dendrimers that are expected to play a significant role in future applications; Analysis of nanomaterials-related patents issued during the past 2 years; Profiles of major and minor companies working with nanoparticles.

INTRODUCTION REASON FOR THE STUDY AND ITS IMPORTANCE OBJECTIVES OF THIS STUDY AND ITS CONTRIBUTION AUDIENCE FOR THIS REPORT SCOPE AND CONTENT OF THIS REPORT METHODOLOGY AND INFORMATION SOURCES ANALYST CREDENTIALS RELATED BCC REPORTS BCC ONLINE SERVICES DISCLAIMER

EXECUTIVE SUMMARY

SUMMARY TABLE TOTAL WORLD MARKET PROJECTIONS FOR

NANOPARTICLES IN BIOMEDICAL, PHARMACEUTICAL AND

COSMETIC APPLICATIONS, THROUGH 2012 ($ MILLIONS)

SUMMARY FIGURE TOTAL WORLD MARKET SHARE PROJECTIONS

FOR BIOMEDICAL, PHARMACEUTICAL AND COSMETIC

APPLICATIONS OF NANOPARTICLES, 2006-2012 (%)

OVERVIEW TERMINOLOGY PRODUCTS AND PROPERTIES

TABLE 1 SUMMARY OF PROPERTY CHANGES AT THE NANOCRYSTALLINE-SIZE SCALE

CATALYTIC

ELECTRICAL

MAGNETIC

Magnetic (Continued)

MECHANICAL

OPTICAL AND ELECTRONIC

HISTORICAL BACKGROUND

HISTORICAL BACKGROUND (CONTINUED)

FIGURE 1 TIMELINE OF INDUSTRY EVENTS, 1920-2000

NANOPARTICLE TECHNOLOGIES PARTICLE PRODUCTION TECHNOLOGIES FOR PRODUCING INORGANIC NANOPARTICLES

TABLE 2 CLASSES OF INORGANIC NANOPARTICLE PRODUCTION METHODS

TABLE 3 PARTICLE PRODUCTION TECHNOLOGIES AND COMPANIES USING THEM

TABLE 3 (CONTINUED)

Gas-Phase Processing

Gas Condensation with Thermal Evaporation

Vacuum Evaporation on Running Liquids (VERL)

FIGURE 2 SCHEMATIC OF THE MODIFIED VERL PROCESS TO PRODUCE METAL NANOSUSPENSIONS

Thermal Plasma Synthesis

Combustion Synthesis

Wet-Chemical Processes

Chemical Precipitation

Hydrothermal Processing

Sol-Gel Processing

FIGURE 3 SOL-GEL SYNTHESIS FLOW CHART

Solid-State Processes

High-Energy Milling

Mechanochemical Synthesis

TECHNOLOGIES FOR PRODUCING ORGANIC

NANOPARTICLES

Lipids

Dendrimers

PRODUCING STABLE DISPERSIONS

PRODUCTION OF COATINGS, COMPONENTS, AND DEVICES

COATINGS

Slurry-Coating Routes

Dip Coating

Spin Coating

Comparison with Vapor-Deposition Techniques

TABLE 4 COMPARISON OF COATING TECHNOLOGIES

Electrophoretic Deposition

Jet-Printing Process

Thermal Spray Coating

Direct Production of Nanostructured Coatings and Bulk

Solids

Electrodeposition

Amorphous Crystallization

COMPONENTS AND DEVICES

Consolidation of Nanoparticles into Components

Three-Dimensional Gel Lamination

Dynamic-Magnetic Consolidation

Field-Assisted Sintering Techniques

Quasi-Isostatic Pressure Process

Shockwave Compaction

Sinter Forging

Severe Plastic Deformation

SELF-ASSEMBLY OF NANOPARTICLES

“BRICKS-AND-MORTAR”APPROACH ORDERS GOLD

PARTICLES

MICELLES ENABLE ASSEMBLY OF NANOLAMINATES

VIRAL BIOTEMPLATE ORGANIZES NANOMETAL

PARTICLES INTO ARRAYS

MAGNETIC NANOPARTICLE DISPERSIONS SELFASSEMBLE

INTO ORDERED ARRAYS

U.S. PATENT ANALYSIS

Introduction

Trends by Country

Trends by Assignee

FIGURE 4 U.S. PATENT TRENDS BY ASSIGNEE’S COUNTRY (NUMBER OF PATENTS ISSUED BETWEEN 10/15/2005 AND 10/15/2007)

FIGURE 5 SHARES OF U.S. PATENTS BY ASSIGNEE (%)

TABLE 5 COMPANIES AND INSTITUTIONS AWARDED TWO OR MORE NANOMATERIAL-RELATED PATENTS BETWEEN OCTOBER 15, 2005 AND OCTOBER 15, 2007

Trends by Emphasis: Production versus Application

FIGURE 6 SHARES OF PATENTS ISSUED BY EMPHASIS (%)

INDUSTRY STRUCTURE PRODUCERS

TABLE 6 COMPANIES WORLDWIDE INVOLVED IN NANOPARTICLE DEVELOPMENT OR PRODUCTION FOR BIOMEDICAL AND COSMETIC APPLICATIONS

TABLE 7 (CONTINUED)

FIGURE 7 GEOGRAPHICAL DISTRIBUTION OF COMPANIES INVOLVED IN NANOPARTICLE DEVELOPMENT OR PRODUCTION FOR BIOMEDICAL AND COSMETIC APPLICATIONS (%)

COMMERCIAL PRODUCTS

NANOPARTICLE PRICING

TABLE 7 FACTORS THAT IMPACT THE PRICING OF NANOPARTICLES

COMMERCIALIZATION STRATEGIES

INTERNATIONAL COMPETITION

REGULATORY ENVIRONMENT

REGULATION IN THE U.S

U.S. Food and Drug Administration

Medical Devices

Drugs and Biologicals

Combination Products

U.S. Environmental Protection Agency

Other Agencies

REGULATION OVERSEAS

GOVERNMENT FUNDING

NATIONAL NANOTECHNOLOGY INITIATIVE (NNI)

TABLE 8 NNI BUDGET REQUESTS FOR NATIONAL INSTITUTES OF HEALTH, 2004-2008 ($ MILLIONS)

FIGURE 8 RECENT TRENDS IN U.S. NATIONAL NANOTECHNOLOGY INITIATIVE SPENDING ON BIOMEDICAL R&D NANOTECHNOLOGY RESEARCH, FY 2004-2008 (BUDGET REQUESTS IN $ MILLIONS)

THE ADVANCED TECHNOLOGY PROGRAM (ATP)

Background

Relevant Awards

TABLE 9 ADVANCED TECHNOLOGY PROGRAM AWARDS RELATED TO BIOMEDICAL, PHARMACEUTICAL, AND COSMETIC APPLICATIONS OF NANOPARTICLES, 1999-2008 ($ MILLIONS)

SMALL BUSINESS INNOVATION RESEARCH (SBIR) AND SMALL BUSINESS TECHNOLOGY TRANSFER (STTR)

PROGRAMS

Background

Relevant Awards

TABLE 10 RECIPIENTS OF THREE OR MORE NANOMATERIALSRELATED PHASE I SBIR/STTR AWARDS, 1991-2007 (NUMBERS ARE LOWER-BOUNDS)

WORLD MARKETS INTRODUCTION WORLD MARKETS OVERVIEW OVERALL MARKET FOR NANOPARTICLES IN BIOMEDICAL, PHARMACEUTICAL, AND COSMETIC APPLICATIONS

FIGURE 9 WORLD MARKET PROJECTIONS FOR NANOPARTICLES IN BIOMEDICAL, PHARMACEUTICAL AND COSMETIC APPLICATIONS, 2006-2012 ($ MILLIONS)

FIGURE 10 WORLD MARKET FORECAST FOR NANOPARTICLES IN BIOMEDICAL, PHARMACEUTICAL, AND COSMETIC APPLICATIONS, 2006-2012 (MILLION KG)

MARKET SEGMENTATION BY APPLICATION

Segmentation in Terms of Value

TABLE 11 WORLD MARKET PROJECTIONS FOR NANOPARTICLES IN BIOMEDICAL, PHARMACEUTICAL, AND COSMETIC APPLICATIONS BY TYPE OF APPLICATION IN TERMS OF VALUE, THROUGH 2012 ($ MILLIONS)

TABLE 11 (CONTINUED)

FIGURE 11 WORLD NANOPARTICLES MARKET SHARE PROJECTIONS BY APPLICATION, 2006-2012 (%)

Segmentation in Terms of Volume

TABLE 12 WORLD MARKET PROJECTIONS FOR NANOPARTICLES IN BIOMEDICAL, PHARMACEUTICAL, AND COSMETIC APPLICATIONS BY APPLICATION IN TERMS OF VOLUME, THROUGH 2012 (KG)

MARKET SEGMENTATION BY MATERIAL TYPE

Segmentation in Terms of Value

TABLE 13 WORLD MARKET PROJECTIONS FOR NANOPARTICLES IN BIOMEDICAL, PHARMACEUTICAL, AND COSMETIC APPLICATIONS BY MATERIAL TYPE IN TERMS OF VALUE, THROUGH 2012 ($ MILLIONS)

FIGURE 12 WORLD MARKET SHARE PROJECTIONS FOR NANOPARTICLES BY MATERIAL TYPE, 2006-2012 (%)

Segmentation in Terms of Volume

TABLE 14 WORLD MARKET PROJECTIONS FOR NANOPARTICLES IN BIOMEDICAL, PHARMACEUTICAL, AND COSMETIC APPLICATIONS BY MATERIAL TYPE IN TERMS OF VOLUME, THROUGH 2012 (KG)

DETAILED MARKET ANALYSIS

ANTIMICROBIAL MATERIALS

Background

Materials, Production, and Technical Requirements

Commercial and Regulatory Status

Antimicrobial Materials

TABLE 15 ANTIMICROBIAL PRODUCTS INCORPORATING SILVER NANOPARTICLES

Nucryst Pharmaceuticals

Surfacine Development Co

Try Co

Fraunhofer Institute

Mineral Supplements

World Markets

FIGURE 13 PROJECTED TRENDS IN THE WORLD MARKET FOR NANOPARTICULATE SILVER USED IN ANTIMICROBIAL APPLICATIONS, 2006-2012 ($ MILLIONS)

Antimicrobial Dressings

TABLE 16 WORLD MARKET PROJECTIONS FOR NANOPARTICULATE SILVER, THROUGH 2012 (KG/$ MILLIONS)

Dietary Supplements

BIOLOGICAL DETECTION AND LABELING

Background

Materials, Production, and Technical Requirements

TABLE 17 BASIC REQUIREMENTS OF DIAGNOSTIC TESTS

Commercial and Regulatory Status

Established Applications

Colloidal Gold

TABLE 18 RAPID DIAGNOSTIC TESTS THAT USE GOLD NANOPARTICLES AS LABELS

Nanoprobes, Inc.

Orasure Technologies, Inc

Dendrimers

Emerging Technologies and Applications

TABLE 19 EMERGING NANOPARTICLE-BASED TECHNOLOGIES FOR BIODETECTION AND LABELING BY COMPANY

TABLE 20 COMPARISON OF VARIOUS TYPES OF EMERGING NANOPARTICULATE LABELING TECHNOLOGIES

BioCrystal, Ltd

Evident Technologies

MagnaBioSciences, LLC

Microcosm, Inc

Nanocrystal Technologies, LP

Nanosphere, Inc.

NymoxPharmaceutical Corp

Quantum Dot Corp.

TABLE 21 COMPARISON BETWEEN QDOTS AND CONVENTIONAL ORGANIC DYES

World Markets

TABLE 22 WORLD MARKET PROJECTIONS FOR NANOPARTICLES IN BIODETECTION AND LABELING APPLICATIONS, THROUGH 2012 (KG/$ MILLIONS)

FIGURE 14 PROJECTED TRENDS IN THE WORLD MARKET FOR NANOPARTICLES USED IN BIODETECTION AND LABELING APPLICATIONS, 2006-2012 ($ MILLIONS)

Colloidal Gold

TABLE 23 WORLD MARKET PROJECTIONS FOR NANOPARTICULATE GOLD USED IN BIOLABELING APPLICATIONS, THROUGH 2012 (KG/$ MILLIONS)

Dendrimers

TABLE 24 WORLD MARKET PROJECTIONS FOR DENDRIMERS

USED IN BIOLABELING APPLICATIONS, THROUGH 2012 (KG/$ MILLIONS)

Semiconductor Nanoparticles

TABLE 25 WORLD MARKETPROJECTIONS FOR SEMICONDUCTOR

NANOPARTICLES USED IN BIOLABELING APPLICATIONS, THROUGH 2012 (KG/$ MILLIONS)

Superparamagnetic Particles

TABLE 26 WORLD MARKET PROJECTIONS FOR SUPERPARAMAGNETIC NANOPARTICLES USED IN BIOLABELING APPLICATIONS, THROUGH 2012 (KG/$ MILLIONS)

BIOMAGNETIC SEPARATIONS

Background

Materials, Production, and Technical Requirements

Commercial and Regulatory Status

TABLE 27 PRODUCERS OF SUPERPARAMAGNETIC MICROSPHERES FOR BIOLOGICAL SEPARATION APPLICATIONS

World Markets

TABLE 28 WORLD MARKETS FOR IRON OXIDE NANOPARTICLES IN BIOMAGNETIC SEPARATIONS, THROUGH 2012 (KG/$ MILLIONS)

FIGURE 15 PROJECTED TRENDS IN THE WORLD MARKET FOR NANOPARTICULATE IRON OXIDE USED IN BIOSEPARATION APPLICATIONS, 2006-2012 ($ MILLIONS)

DRUG DELIVERY

Background

TABLE 29 CRITERIA FOR A NANOPARTICULATE DRUG DELIVERY VEHICLE

Materials, Production, and Technical Requirements

Commercial and Regulatory Status

TABLE 30 COMPANIES ACTIVE IN THE DEVELOPMENT OF NANOPARTICLES FOR DRUG-DELIVERY APPLICATIONS

Cytimmune Sciences

TABLE 31 TIMELINE OF NEW DRUG DEVELOPMENT PROCESS

PowderMed, Ltd

SkyePharma

Starpharma

World Markets

TABLE 32 WORLD MARKET PROJECTIONS FOR DENDRIMERBASED DRUG DELIVERY SYSTEMS, THROUGH 2012 (KG/$ MILLIONS)

MAGNETIC RESONANCE IMAGING (MRI) CONTRAST

AGENTS

Background

TABLE 33 TYPES OF CONTRAST AGENTS USED FOR MRI IMAGING

Materials, Production, and Technical Requirements

Commercial and Regulatory Status

TABLE 34 SUPERPARAMAGNETIC IRON OXIDE CONTRAST MEDIA: REGULATORY AND MARKETING STATUS

World Markets

TABLE 35 WORLD MARKET PROJECTIONS FOR NANOPARTICULATE IRON OXIDE USED IN MRI CONTRAST MEDIA, THROUGH 2012 (KG/$ MILLIONS)

FIGURE 16 PROJECTED TRENDS IN THE WORLD MARKET FOR NANOPARTICULATE IRON OXIDE USED IN MRI CONTRAST APPLICATIONS, 2006-2012 ($ MILLIONS)

TRANSFECTION REAGENTS

Background

Materials, Production, and Technical Requirements

Commercial and Regulatory Status

World Markets

TABLE 36 WORLD MARKET PROJECTIONS FOR DENDRIMERS USED IN TRANSFECTON REAGENTS, THROUGH 2012

FIGURE 17 PROJECTED TRENDS IN THE WORLD MARKET FOR DENDRIMERS USED IN TRANSFECTION REAGENTS, 2006-2012 ($ MILLIONS)

ANTIOXIDANTS

Background

Materials, Production, and Technical Requirements

Commercial and Regulatory Status

World Markets

TABLE 37 WORLD MARKET PROJECTIONS FOR SILICA HYDRIDE NANOPARTICLES USED IN NUTRACEUTICALS, THROUGH 2012 (KG/$ MILLIONS)

FIGURE 18 PROJECTED TRENDS IN THE WORLD MARKET FOR SILICA HYDRIDE NANOPARTICLES USED IN ANTIOXIDANT NUTRACEUTICAL, 2006-2012 ($ MILLIONS)

ORTHOPEDIC AND DENTAL APPLICATIONS

Background

Materials, Production, and Technical Requirements

Commercial and Regulatory Status

TABLE 38 COMPANIES ACTIVE IN DEVELOPING NANOPARTICLEBASED BIOACTIVE CERAMICS

World Markets

TABLE 39 WORLD MARKET PROJECTIONS FOR NANOPARTICLEBASED SYNTHETIC BONE AND TOOTH ENAMELS, THROUGH 2012 (KG/$ MILLIONS)

FIGURE 19 PROJECTED TRENDS IN THE WORLD MARKET FOR NANOPARTICULATE HYDROXYAPATITE, 2006-2012 ($ MILLIONS)

World Markets (Continued)

SUNSCREENS AND UV-PROTECTIVE COSMETICS

Background

TABLE 40 SUNSCREEN INORGANIC AND ORGANIC ACTIVE INGREDIENTS

Materials, Production, and Technical Requirements

TABLE 41 TECHNICAL REQUIREMENTS FOR NANOPARTICLES IN UV-SHIELDING APPLICATIONS

Commercial and Regulatory Status

TABLE 42 PRODUCERS OF TIO2 AND ZNO PARTICLES AND DISPERSIONS

Commercial and Regulatory Status (Continued)

TABLE 43 SUNSCREEN AND DAILY-USE SKIN PROTECTION PRODUCTS CONTAINING NANOPARTICULATE TIO2 AND ZNO

Recent Developments

Process for Preparing Passivated TiO2

Nanoparticles

Titanium Dioxide Coated with Silicon Dioxide

Coated TiO2 Nanoparticles

World Markets

TABLE 44 PROJECTED TRENDS IN WORLDWIDE SUNSCREEN SALES, THROUGH 2012 ($ BILLIONS)

FIGURE 20 PROJECTED TRENDS IN THE WORLD MARKET FOR TIO2 AND ZNO NANOPARTICLES USED IN SUNCREENS AND OTHER SKIN CARE PRODUCTS, 2006-2012 ($ MILLIONS)

TABLE 45 WORLD MARKET PROJECTIONS FOR TIO2 AND ZNO NANOPARTICLES IN SUNSCREEN APPLICATIONS, THROUGH 2012 (KG/$ MILLIONS)

COMPANY PROFILES ADVANCED NANOTECHNOLOGY, LTD AMAG PHARMACEUTICALS, INC ALTAIR NANOTECHNOLOGIES, INC ANGSTROM MEDICA, INC. APHIOS CORP ARGONIDE CORP BANGS LABORATORIES, INC BASF AG BERKELEY ADVANCED BIOMATERIALS, INC BIOPHAN TECHNOLOGIES, INC. CAPSULUTION NANOSCIENCE AG CYTIMMUNE SCIENCES, INC. DENDRITECH, INC DENDRITIC NANOTECHNOLOGIES, INC. DOW CHEMICAL CO. DONG SEO, INC DYNAL BIOTECH ASA ELEMENTIS SPECIALTIES EMD CHEMICALS, INC. EVIDENT TECHNOLOGIES EVONIK DEGUSSA GMBH FLAMEL TECHNOLOGIES S.A. INFRAMAT CORP INVITROGEN CORP ISHIHARA SANGYO KAISHA, LTD KEMIRA SPECIALTY MAGNABIOSCIENCES, LLC MICROCOSM, INC MICROMOD PARTIKELTECHNOLOGIE GMBH NANOCARRIER CORP., LTD. NANOPHASE TECHNOLOGIES CORP NANOPROBES, INC. NANOSPHERE, INC NOVAVAX, INC NUCRYST PHARMACEUTICALS NYMOX PHARMACEUTICAL CORP. ORASURE TECHNOLOGIES, INC ORTHOVITA, INC OSI PHARMACEUTICALS, INC PHARMASOL GMBH POLYSCIENCES, INC. POWDERMED, LTD QUANTUM DOT CORP. QIAGEN N.V RBC LIFE SCIENCES, INC SACHTLEBEN CHEMIE GMBH SHOWA DENKO K.K SKYEPHARMA, PLC SOMALOGIC, INC. STARPHARMA HOLDINGS, LTD. SURFACINE DEVELOPMENT CO. TAYCA CORP.

LIST OF TABLES

SUMMARY TABLE TOTAL WORLD MARKET PROJECTIONS FOR NANOPARTICLES IN BIOMEDICAL, PHARMACEUTICAL AND COSMETIC APPLICATIONS, THROUGH 2012 ($ MILLIONS)