Cardiovascular Medicine: Diagnostics, Drugs and Devices

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Cardiovascular Medicine: Diagnostics, Drugs and Devices

Report price : $ 4 850
Publication date : November 2007

This report contains: Descriptions of various types of cardiovascular diagnostics such as in vitro tests and in vivo imaging techniques, devices such as drug eluting stents, and drugs such as Pfizer's blockbuster Lipitor; The current market status of cardiovascular diagnostics, devices and drugs, along with trends and forecasts for growth over the next 5 years; Technological issues including the latest developments and a thorough patent analysis; Analysis of the cardiovascular diagnostics, devices and drugs industry, both from a market and application perspective; Information about the major players in each market, including Medtronic and Boston Scientific in devices, Sanofi-Aventis and BMS in drugs, and Abbott in devices.

INTRODUCTION STUDY GOALS AND OBJECTIVES REASONS FOR DOING THE STUDY INTENDED AUDIENCE SCOPE OF REPORT INFORMATION SOURCES ANALYST’S CREDENTIALS RELATED REPORTS FROM BCC RESEARCH BCC ONLINE SERVICES DISCLAIMER

SUMMARY THE CARDIOVASCULAR DIAGNOSTIC, DRUG, AND DEVICE MARKETS

SUMMARY TABLE WORLDWIDE REVENUE OF CARDIOVASCULAR DIAGNOSTICS, DRUGS, AND DEVICES, THROUGH 2012 ($ BILLIONS)

SUMMARY FIGURE WORLDWIDE REVENUE OF CARDIOVASCULAR DIAGNOSTICS, DRUGS, AND DEVICES, 2005-2012 ($ BILLIONS)

OVERVIEW WHAT IS CARDIOVASCULAR (CV) DISEASE? CAUSES OF CARDIOVASCULAR DISEASE CAUSES OF CARDIOVASCULAR DISEASE (CONTINUED) CARDIOVASCULAR DIAGNOSTICS CARDIOVASCULAR MEDICINE CARDIOVASCULAR DEVICES

CARDIOVASCULAR DISEASES DISEASES OF THE HEART (CARDIO) AND DISEASES OF THE BLOOD VESSELS (VASCULAR) DISEASES OF THE HEART Coronary Artery Disease (CAD) Coronary Heart Disease (CHD) Cardiomyopathy Valvular Heart Disease Pericardial Disease Congenital Heart Disease Heart Failure DISEASE OF BLOOD VESSELS Arteriosclerosis and Atherosclerosis High Blood Pressure Stroke Aneurysm Peripheral Arterial Disease and Claudication (PAD) Vasculitis Venous Incompetence Venous Thrombosis Varicose Veins Lymphedema EPIDEMIOLOGY OF CARDIOVASCULAR DISEASE Global Distribution Pattern in 2004 Age Gender Role of Risk Factors Risk Factors Psychological and Social Factors Prevention of Cardiovascular Disease

PREVALANCE OF CARDIOVASCULAR DISEASES MAJOR CAUSE OF DEATH THE EPIDEMIOLOGICAL TRANSITION PREVALENCE OF HEART DISEASE IN VARIOUS CATEGORIES Age Gender Race/ Ethnicity Education

TABLE 1 PREVALENCE OF STROKE, MYOCARDIAL INFARCTION, AND ANGINA PECTORIS BY VARIOUS CATEGORIES, 2005

FIGURE 1 PREVALENCE OF STROKE, MYOCARDIAL INFARCTION, AND ANGINA PECTORIS BY AGE GROUP, 2005 (%)

FIGURE 2 PREVALENCE OF STROKE, MYOCARDIAL INFARCTION, AND ANGINA PECTORIS BY GENDER, 2005 (%)

FIGURE 3 PREVALENCE OF STROKE, MYOCARDIAL INFARCTION, AND ANGINA PECTORIS BY RACE/ETHINICITY, 2005 (%)

FIGURE 4 PREVALENCE OF STROKE, MYOCARDIAL INFARCTION, AND ANGINA PECTORIS BY EDUCATION 2005 (%)

PREVALENCE OF CARDIOVASCULAR DISEASES IN THE U.S.

TABLE 2 PREVALENCE OF CARDIOVASCULAR DISEASES IN U.S., 2005 (MILLION PEOPLE)

FIGURE 5 PREVALENCE OF CARDIOVASCULAR DISEASES IN THE U.S., 2005 (MILLION PEOPLE)

COST OF CARDIOVASCULAR DISEASES IN THE U.S.

TABLE 3 COST OF CARDIOVASCULAR DISEASES IN U.S. THROUGH 2012 ($ BILLIONS)

FIGURE 6 COST OF CARDIOVASCULAR DISEASES IN THE U.S., 2005-2012 ($ BILLIONS)

PREVALENCE AND COST OF CARDIOVASCULAR

DISEASES IN EUROPE

MORTALITY DUE TO CARDIOVASCULAR DISEASES U.S

TABLE 4 MORTALITY DUE TO CARDIOVASCULAR DISEASES IN THE U.S., 2005 (%)

TABLE 4 (CONTINUED)

FIGURE 7 MORTALITY DUE TO CARDIOVASCULAR DISEASES IN THE U.S. 2005 (%)

Europe

TABLE 5 MORTALITY DUE TO CARDIOVASCULAR DISEASES IN EUROPE, 2005 (%)

FIGURE 8 MORTALITY DUE TO CARDIOVASCULAR DISEASES IN THE U.S., 2005 (%)

REGULATORY ISSUES CARDIOVASCULAR DRUGS APPROVED BY FDA

TABLE 6 CARDIOVASCULAR DRUGS APPROVED BY FDA, 2002-2007*

FIGURE 9 CARDIOVASCULAR DRUGS APPROVED BY FDA, 2002-2007*

CARDIOVASCULAR DEVICES APPROVED BY THE FDA

TABLE 7 CARDIOVASCULAR DEVICES APPROVED BY THE FDA, 2002-2007*

TABLE 7 (CONTINUED)

FIGURE 10 CARDIOVASCULAR DEVICES APPROVED BY THE FDA 2002-2007*

CARDIOVASCULAR DRUGS RECALLED BY FDA

TABLE 8 CARDIOVASCULAR DRUGS RECALLED BY THE FDA, 2002-2007*

CARDIOVASCULAR DEVICES RECALLED BY FDA

TABLE 9 CARDIOVASCULAR DEVICES RECALLED BY THE FDA, 2002-2007*

TABLE 9 (CONTINUED)

FIGURE 11 CARDIOVASCULAR DEVICES RECALLED BY FDA, 2002-2007*

FIGURE 11 (CONTINUED)

NEW DRUG APPLICATIONS

NEW DRUG APPLICATIONS (CONTINUED)

CARDIOVASCULAR DIAGNOSTICS DIAGNOSTICS DEFINITION IN VITRO DIAGNOSTIC BIOMARKERS Aspartate Aminotransferase (AST/GOT) Lactate Dehydrogenase and its Isoenzyme LD Creatine Kinase (CK) and its Isoenzyme MB Myoglobin Cardiac Troponins Reasons behind the Replacement of CKMB with Troponins Myoglobin/Carbonic Anhydrase III Ratio Glycogen Phosphorylase Isoenzyme BB Heart Type Fatty Acid Binding Protein COMPARISON BETWEEN CTNT AND CTNL Natriuretic Peptides as Cardiac Biomarkers

TABLE 10 NT-PROBNP IN ACUTE SITUATIONS

TABLE 11 NT-PROBNP IN PRIMARY CARE SETTING

POINT-OF-CARE TESTING

NEED FOR THE POCT

TABLE 12 ADVANTAGES OF POINT OF CARE TESTING

TABLE 13 DISADVANTAGES OF POINT OF CARE TESTING

Past, Present, and Future of Point-of-Care Testing

Past

Present

Future

DETERMINING WHETHER TO USE POC CARDIAC

TESTING IN THE ED

Considerations of Turnaround Times

The Importance of Quantitative Results

Concerns about Standardization

VENUES FOR POC TESTING

TABLE 14 VENUES FOR POC TESTING

IN VIVO DIAGNOSTICS

ECHOCARDIOGRAPHY

Need of the Echocardiography

TABLE 15 TYPES OF ECHOCARDIOGRAMS

ULTRASOUND

TABLE 16 TYPES OF DOPPLER ULTRASOUND

Advantages of Ultrasound

MRI

Need of MRI Scan

POSITRON EMISSION TOMOGRAPHY

COMPUTED TOMOGRAPHY

Electron-Beam Computed Tomography (EBCT or

Ultrafast CT)

Electron-Beam Computed (Continued)

CARDIOVASCULAR THERAPY CARDIOVASCULAR DRUGS ANTI-ANGINAL AGENTS

TABLE 17 COMMONLY USED ANTI-ANGINAL AGENTS

ANTI-ARRHYTHMIC AGENTS

TABLE 18 COMMONLY USED ANTI-ARRHYTHMIC AGENTS

ANTI-HYPERTENSIVE DRUGS

TABLE 19 COMMONLY USED ANTI-HYPERTENSIVE AGENTS

ANTI-THROMBOTIC AGENTS

BLOOD LIPID LOWERING AGENTS

TABLE 20 COMMONLY USED BLOOD LIPID LOWERING AGENTS

DRUGS USED TO TREAT CONGESTIVE HEART FAILURE

TABLE 21 COMMONLY USED DRUGS TO TREAT CONGESTIVE HEART FAILURE

CARDIOVASCULAR DEVICES

PACEMAKERS

TABLE 22 PACEMAKERS

Defibrillators

Manual External Defibrillators

Manual Internal Defibrillator

Automated External Defibrillator

Semi-automated External Defibrillator

Implantable Cardioverter Defibrillator

Drug-Eluting Stents (DES)

Catheters

Valves

Mechanical Heart Valve

Biological Heart Valve

Ventricular Assist Device

Guidewires

Artificial Heart

CARDIAC RESYNCHRONIZATION THERAPY

Cardiac Resynchronization Therapy

Cardiac Resynchronization Therapy Devices

Difference between Biventricular Pacemaker and

Standard Pacemaker

Use of CRT

Benefits of CRT

Potential Risks with Biventricular Pacemakers

INDUSTRY STRUCTURE CARDIOVASCULAR DIAGNOSTICS CARDIAC BIOMARKERS

TABLE 23 PRESENT CARDIAC MARKER TESTING

Market Shares for Companies Providing Biomarker Tests

TABLE 24 MARKET SHARE OF COMPANIES PROVIDING BIOMARKER TESTS, 2006 (%)

FIGURE 12 MARKET SHARE OF COMPANIES PROVIDING BIOMARKER TESTS, 2006 (%)

Effect of POCT on the Growth of Cardiac Biomarker

Testing in Laboratory

POINT OF TESTING FOR CARDIAC BIOMARKERS

TABLE 25 PRESENT POINT-OF-CARE TESTING FOR CARDIAC BIOMARKERS

Market Shares for Companies Providing Biomarker Tests

TABLE 26 MARKET SHARE OF COMPANIES PROVIDING POINT-OFCARE TESTING FOR CARDIAC BIOMARKERS, 2006 (%)

FIGURE 13 MARKET SHARE OF COMPANIES PROVIDING POINT-OF CARE TESTING FOR CARDIAC BIOMARKERS, 2006 (%)

Factors Influencing the Growth of Point-of-Care Testing

Challenges for the Manufacturers

IN-VIVO DIAGNOSTICS

TABLE 27 PRESENT IMAGING SYSTEMS FOR IN-VIVO DIAGNOSIS

Market Shares for Companies Providing In-Vivo

Diagnostics

TABLE 28 MARKET SHARE OF COMPANIES PROVIDING IN-VIVO DIAGNOSTICS, 2006 (%)

FIGURE 14 MARKET SHARE OF COMPANIES PROVIDING IN-VIVO DIAGNOSTICS, 2006 (%)

Factors Affecting the Growth of Cardiac Imaging or In

vivo Diagnostics

CARDIOVASCULAR DRUGS

ANTI-ANGINAL AGENTS

TABLE 29 GLOBAL MARKET LEADERS OF ANTI-ANGINAL AGENTS

Market Shares for Anti-anginal Agents

TABLE 30 MARKET SHARE OF COMPANIES MANUFACTURING ANTI-ANGINAL AGENTS, 2006 (%)

FIGURE 15 MARKET SHARE OF COMPANIES MANUFACTURING ANTI-ANGINAL AGENTS, 2006 (%)

ANTI-ARRYHTHMIC AGENTS

TABLE 31 GLOBAL MARKET LEADERS OF ANTI-ARRHYTHMIC AGENTS

Market Shares for Anti-arrhythmic Agents

TABLE 32 MARKET SHARE OF COMPANIES MANUFACTURING ANTI-ARRHYTHMIC AGENTS, 2006 (%)

FIGURE 16 MARKET SHARE OF COMPANIES MANUFACTURING ANTI-ARRHYTHMIC AGENTS, 2006 (%)

ANTI-HYPERTENSIVE AGENTS

TABLE 33 GLOBAL MARKET LEADERS OF ANTI-HYPERTENSIVE AGENTS

Market Shares for Anti-hypertensive Agents

TABLE 34 MARKET SHARE OF COMPANIES MANUFACTURING ANTI-HYPERTENSIVE AGENTS, 2006 (%)

FIGURE 17 MARKET SHARE OF COMPANIES MANUFACTURING ANTI-HYPERTENSIVE AGENTS, 2006 (%)

ANTI-THROMBOTIC AGENTS

TABLE 35 GLOBAL MARKET LEADERS OF ANTI-THROMBOTIC AGENTS

Market Shares for Anti-thrombotic Agents

TABLE 36 MARKET SHARE OF COMPANIES MANUFACTURING ANTI-THROMBOTIC AGENTS, 2006 (%)

FIGURE 18 MARKET SHARE OF COMPANIES MANUFACTURING ANTI-THROMBOTIC AGENTS, 2006 (%)

BLOOD LIPID LOWERING AGENTS

TABLE 37 GLOBAL MARKET LEADERS OF BLOOD LIPID LOWERING AGENTS

Market Shares for Blood Lipid Lowering Agents

TABLE 38 MARKET SHARE OF COMPANIES MANUFACTURING BLOOD LIPID LOWERING AGENTS, 2006 (%)

FIGURE 19 MARKET SHARE OF COMPANIES MANUFACTURING BLOOD LIPID LOWERING AGENTS, 2006 (%)

DRUGS TREATING CONGESTIVE HEART FAILURE

TABLE 39 GLOBAL MARKET LEADERS OF DRUGS TREATING CONGESTIVE HEART FAILURE

Market Shares for Drugs Treating Congestive Heart

Failure

TABLE 40 MARKET SHARE OF COMPANIES MANUFACTURING DRUGS TREATING CONGESTIVE HEART FAILURE, 2006 (%)

TABLE 40 (CONTINUED)

FIGURE 20 MARKET SHARE OF COMPANIES MANUFACTURING DRUGS TREATING CONGESTIVE HEART FAILURE, 2006 (%)

FACTORS AFFECTING THE SALES OF CARDIOVASCULAR

DRUGS

Price Control/Price pressure

Expiration of Patents

MAJOR FACTORS FOR FUTURE GROWTH

Life Expectancy

Access of Senior Citizens to Prescription Drugs

Patent Protection

Drugs Portfolio Management

Significant Potential of Developing Countries

CARDIOVASCULAR DEVICES

PACEMAKERS

TABLE 41 GLOBAL MARKET LEADERS OF MANUFACTURERS OF PACEMAKERS

Market Shares of Companies Manufacturing Pacemakers

TABLE 42 MARKET SHARE OF COMPANIES MANUFACTURING PACEMAKERS, 2006 (%)

FIGURE 21 MARKET SHARE OF COMPANIES MANUFACTURING PACEMAKERS, 2006 (%)

CARDIOVERTER DEFIBRILLATORS

TABLE 43 GLOBAL MARKET LEADERS OF MANUFACTURERS OF CONVENTIONAL CARDIOVERTER DEFIBRILLATORS

TABLE 44 GLOBAL MARKET LEADERS OF MANUFACTURERS OF CRT-DEFIBRILLATORS

Market Shares of Companies Manufacturing

Conventional Cardioverter Defibrillators

TABLE 45 MARKET SHARE OF COMPANIES MANUFACTURING CONVENTIONAL CARDIOVERTER DEFIBRILLATORS, 2006 (%)

FIGURE 22 MARKET SHARE OF COMPANIES MANUFACTURING CONVENTIONAL CARDIOVERTER DEFIBRILLATORS, 2006 (%)

Market Shares of Companies Manufacturing CRTDefibrillators

TABLE 46 MARKET SHARE OF COMPANIES MANUFACTURING CRT-DEFIBRILLATORS, 2006 (%)

FIGURE 23 MARKET SHARE OF COMPANIES MANUFACTURING CRT-DEFIBRILLATORS, 2006 (%)

DRUG ELUTING STENTS

TABLE 47 GLOBAL MARKET LEADERS OF MANUFACTURERS OF DRUG ELUTING STENTS

Market Shares of Companies Manufacturing Drug

Eluting Stents

TABLE 48 MARKET SHARE OF COMPANIES MANUFACTURING DRUG ELUTING STENTS, 2006 (%)

FIGURE 24 MARKET SHARE OF COMPANIES MANUFACTURING DRUG ELUTING STENTS, 2006 (%)

CATHETERS

TABLE 49 GLOBAL MARKET LEADERS OF MANUFACTURERS OF CATHETERS

TABLE 49 (CONTINUED)

Market Shares of Companies Manufacturing Catheters

TABLE 50 MARKET SHARE OF COMPANIES MANUFACTURING CATHETERS, 2006 (%)

FIGURE 25 MARKET SHARE OF COMPANIES MANUFACTURING CATHETERS, 2006 (%)

HEART VALVES

TABLE 51 GLOBAL MARKET LEADERS OF MANUFACTURERS OF HEART VALVES

Market Shares of Companies Manufacturing Heart

Valves

TABLE 52 MARKET SHARE OF COMPANIES MANUFACTURING HEART VALVES, 2006 (%)

FIGURE 26 MARKET SHARE OF COMPANIES MANUFACTURING HEART VALVES, 2006 (%)

VENTRICULAR ASSIST DEVICE

TABLE 53 GLOBAL MARKET LEADERS OF MANUFACTURERS OF VENTRICULAR ASSIST DEVICES

Market Shares of Companies Manufacturing Ventricular

Assist Devices

TABLE 54 MARKET SHARE OF COMPANIES MANUFACTURING VENTRICULAR ASSIST DEVICES, 2006 (%)

FIGURE 27 MARKET SHARE OF COMPANIES MANUFACTURING VENTRICULAR ASSIST DEVICES, 2006 (%)

GUIDE WIRES

TABLE 55 GLOBAL MARKET LEADERS OF MANUFACTURERS OF GUIDE WIRES

Market Shares of Companies Manufacturing Guidewires

TABLE 56 MARKET SHARE OF COMPANIES MANUFACTURING GUIDEWIRES, 2006 (%)

FIGURE 28 MARKET SHARE OF COMPANIES MANUFACTURING GUIDEWIRES, 2006 (%)

FACTORS AFFECTING THE SALES OF CARDIOVASCULAR

DEVICES

Aging Baby-Boomers

Regulation

Competitive Landscape of Technology

Shortening of Patent Lives

Business Taxes

MARKET ANALYSIS OF CARDIOVASCULAR DIAGNOSTICS CARDIAC BIOMARKERS

TABLE 57 GLOBAL SALES OF CARDIAC BIOMARKERS, THROUGH 2012 ($ MILLIONS)

FIGURE 29 GLOBAL SALES OF CARDIAC BIOMARKERS, 2005-2012 ($ MILLIONS)

CARDIAC MARKER TESTING BY TYPE

TABLE 58 ESTIMATED WORLDWIDE MARKET FOR CARDIAC MARKER TESTING BY TYPE, THROUGH 2012 ($ MILLIONS)

FIGURE 30 GLOBAL SALES OF CARDIAC BIOMARKERS, BY TYPE, 2005-2012 ($ MILLIONS)

POINT-OF-CARE TESTING

TABLE 59 GLOBAL SALES OF POINT-OF-CARE TESTING, THROUGH 2012 ($ MILLIONS)

FIGURE 31 GLOBAL SALES OF POINT-OF-CARE TESTING, 2005-2012 ($ MILLIONS)

IN VIVO DIAGNOSTICS

In Vivo Diagnostics (Continued)

TABLE 60 GLOBAL SALES OF IN-VIVO DIAGNOSTICS, THROUGH 2012 ($ MILLIONS)

FIGURE 32 GLOBAL SALES OF IN VIVO DIAGNOSTICS. 2005-2012 ($ MILLIONS)

TOTAL MARKET SHARES OF CARDIOVASCULAR

DIAGNOSTICS WORLDWIDE

TABLE 61 WORLDWIDE MARKET SHARE OF CARDIOVASCULAR DIAGNOSTICS, 2006 (%)

FIGURE 33 WORLDWIDE MARKET SHARE OF CARDIOVASCULAR DIAGNOSTICS, 2006 (%)

MARKET ANALYSIS OF CARDIOVASCULAR DRUGS ANTI-ANGINAL AGENTS

TABLE 62 GLOBAL SALES OF ANTI-ANGINAL DRUGS, THROUGH 2012 ($ BILLIONS)

FIGURE 34 GLOBAL SALES OF ANTI-ANGINAL DRUGS, 2005-2012 ($ BILLIONS)

ANTI-ARRHYTHMIC AGENTS

TABLE 63 GLOBAL SALES OF ANTI-ARRHYTHMIC DRUGS, THROUGH 2012 ($ BILLIONS)

FIGURE 35 GLOBAL SALES OF ANTI-ARRHYTHMIC DRUGS, 2005-2012 ($ BILLIONS)

ANTI-HYPERTENSIVE AGENTS

TABLE 64 GLOBAL SALES OF ANTI-HYPERTENSIVE DRUGS, THROUGH 2012 ($ BILLIONS)

FIGURE 36 GLOBAL SALES OF ANTI-HYPERTENSIVE DRUGS, 2005-2012 ($ BILLIONS)

ANTI-THROMBOTIC AGENTS

TABLE 65 GLOBAL SALES OF ANTI-THROMBOTIC DRUGS, THROUGH 2012 ($ BILLIONS)

FIGURE 37 GLOBAL SALES OF ANTI-THROMBOTIC DRUGS, 2005-2012 ($ BILLIONS)

BLOOD LIPID LOWERING AGENTS

TABLE 66 GLOBAL SALES OF BLOOD LIPID LOWERING DRUGS, THROUGH 2012 ($ BILLIONS)

FIGURE 38 GLOBAL SALES OF BLOOD LIPID LOWERING DRUGS, 2005-2012 ($ BILLIONS)

DRUGS USED TO TREAT CONGESTIVE HEART FAILURE

TABLE 67 GLOBAL SALES OF DRUGS USED TO TREAT CONGESTIVE HEART FAILURE, THROUGH 2012 ($ BILLIONS)

FIGURE 39 GLOBAL SALES OF DRUGS USED TO TREAT CONGESTIVE HEART FAILURE, 2005-2012 ($ BILLIONS)

TOTAL WORLDWIDE MARKET SHARES OF CARDIOVASCULAR DRUGS

TABLE 68 MARKET SHARE OF CARDIOVASCULAR DRUGS, 2006 (%)

FIGURE 40 MARKET SHARE OF CARDIOVASCULAR DRUGS, 2006

(%)

CARDIOVASCULAR DEVICES MARKET ANALYSIS PACEMAKERS

TABLE 69 GLOBAL SALES OF PACEMAKERS, THROUGH 2012 ($ MILLIONS)

FIGURE 41 GLOBAL SALES OF PACEMAKERS, 2005-2012 ($ MILLIONS)

IMPLANTABLE CARDIOVERTER DEFIBRILLATORS

TABLE 70 GLOBAL SALES OF CONVENTIONAL IMPLANTABLE CARDIOVERTER DEVICES, THROUGH 2012 ($ MILLIONS)

FIGURE 42 GLOBAL SALES OF IMPLANTABLE CARDIOVERTER DEVICES, 2005-2012 ($ MILLIONS)

TABLE 71 GLOBAL SALES OF CRT-DEFIBRILLATORS, THROUGH 2012 ($ MILLIONS)

FIGURE 43 GLOBAL SALES OF IMPLANTABLE CRTDEFIBRILLATORS, 2005-2012 ($ MILLIONS)

DRUG ELUTING STENTS (DES) AND GRAFTS

Drug Eluting Stents (DES) and Grafts (Continued)

TABLE 72 GLOBAL SALES OF DRUG ELUTING STENTS AND GRAFTS, THROUGH 2012 ($ MILLIONS)

FIGURE 44 GLOBAL SALES OF DRUG ELUTING STENTS AND GRAFTS, 2005-2012 ($ MILLIONS)

CATHETERS

TABLE 73 GLOBAL SALES OF CATHETERS, THROUGH 2012 ($ MILLIONS)

FIGURE 45 GLOBAL SALES OF CATHETERS, 2005-2012 ($ MILLIONS)

HEART VALVES

TABLE 74 GLOBAL SALES OF HEART VALVES, THROUGH 2012 ($ MILLIONS)

FIGURE 46 GLOBAL SALES OF HEART VALVES, THROUGH 2012 ($ MILLIONS)

VENTRICULAR ASSIST DEVICES

TABLE 75 GLOBAL SALES OF VENTRICULAR ASSIST DEVICES, THROUGH 2012 ($ MILLIONS)

FIGURE 47 GLOBAL SALES OF VENTRICULAR ASSIST DEVICES, 2005-2012 ($ MILLIONS)

GUIDEWIRES

TABLE 76 GLOBAL SALES OF GUIDEWIRES, THROUGH 2012 ($ MILLIONS)

FIGURE 48 GLOBAL SALES OF GUIDEWIRES, 2005-2012 ($ MILLIONS)

ARTIFICIAL HEART

TOTAL MARKET SHARES OF CARDIOVASCULAR DEVICES WORLDWIDE

TABLE 77 MARKET SHARE OF CARDIOVASCULAR DEVICES, 2006 (%)

FIGURE 49 MARKET SHARE OF CARDIOVASCULAR DEVICES, 2006 (%)

NEW DEVELOPMENTS/TECHNOLOGICAL INNOVATIONS DIAGNOSTICS SIEMENS MEDICAL SOLUTIONS NEUROSONIX LTD UNIVERSITY HOSPITAL MANNHEIM AND OSPEDALI RIUNITI DI BERGAMO SORIN PHILIPS TOPSPIN MEDICAL SONOSITE, INC. DATASCOPE CORPORATION RESPONSE BIOMEDICAL ASTRAZENECA BMS & PFIZER DECODE GENETICS ENCYSIVE PHARMACEUTICALS INC. EPIX PHARMACEUTICALS, INC LEXICON PHARMACEUTICALS MERCK & COMPANY MOMENTA PHARMACEUTICALS, INC NILE THERAPEUTICS, INC PHARMACOPEIA SANOFI-AVENTIS TAKEDA PHARMACEUTICAL UNIVERSITY OF NORTH CAROLINA DEVICES ABBOTT ABIOMED, INC ATS MEDICAL CARDIATIS CRYOCATH TECHNOLOGIES, INC. CRYOCOR, INC. EDWARD LIFESCIENCES MEDTRONIC, INC. METHODIST DEBAKEY HEART CENTER ST. JUDE MEDICAL, INC. STEM CELLS AND HEART DISEASE STEM CELLS AND HEART DISEASE (CONTINUED)

PATENT ANALYSIS TOTAL PATENTS PATENTS BY YEAR

TABLE 78 TOTAL NUMBER OF SIGNIFICANT PATENTS, 2005-2007

FIGURE 50 NUMBER OF PATENTS, 2005-2007

FIGURE 51 NUMBER OF PATENTS, SHARE BY YEAR, 2005-2007 (%)

PATENTS BY COUNTRY

TABLE 79 TOTAL NUMBER OF PATENTS BY COUNTRY, 2005-2007

FIGURE 52 TOTAL NUMBER OF PATENTS BY COUNTRY, 2005-2007

DIAGNOSTICS PATENTS

PATENTS BY YEAR

TABLE 80 PATENTS FOR DIAGNOSTICS BY YEAR, 2005-2007

FIGURE 53 PATENTS FOR DIAGNOSTICS BY YEAR, 2005-2007

PATENTS BY COUNTRY

TABLE 81 PATENTS BY COUNTRY FOR DIAGNOSTICS, 2005-2007

FIGURE 54 PATENTS BY COUNTRY FOR DIAGNOSTICS, 2005-2007

PATENTS BY COMPANY

TABLE 82 NUMBER OF PATENTS BY COMPANY FOR DIAGNOSTICS

TABLE 82 (CONTINUED)

FIGURE 55 TOTAL NUMBER OF PATENTS BY COMPANY FOR DIAGNOSTICS, 2005-2007

PATENTS BY ASSIGNEE

TABLE 83 NUMBER OF PATENTS BY ASSIGNEE FOR DIAGNOSTICS, 2005-2007

FIGURE 56 NUMBER OF PATENTS BY ASSIGNEE FOR DIAGNOSTICS, 2005-2007

DRUG PATENTS

PATENTS BY COUNTRY

TABLE 84 PATENTS BY COUNTRY FOR DRUGS, 2005-2007

FIGURE 57 PATENTS BY COUNTRY FOR DRUGS, 2005-2007

PATENTS BY COMPANY

TABLE 85 NUMBER OF PATENTS BY COMPANY FOR DRUGS, 2005-2007

TABLE 85 (CONTINUED)

FIGURE 58 TOTAL NUMBER OF PATENTS BY COMPANY FOR DRUGS, 2005-2007

Patents by Assignee

TABLE 86 NUMBER OF PATENTS BY ASSIGNEE FOR DEVICES, 2005-2007

FIGURE 59 NUMBER OF PATENTS BY ASSIGNEE FOR DRUGS, 2005-2007

DEVICE PATENTS

PATENTS BY YEAR

TABLE 87 PATENTS FOR DEVICES BY YEAR, 2005-2007

FIGURE 60 PATENTS FOR DEVICES BY YEAR, 2005-2007

PATENTS BY COUNTRY

TABLE 88 PATENTS BY COUNTRY FOR DEVICES, 2005-2007

FIGURE 61 PATENTS BY COUNTRY FOR DEVICES, 2005-2007

PATENTS BY COMPANY

TABLE 89 NUMBER OF PATENTS BY COMPANY FOR DEVICES, 2005-2007

TABLE 89 (CONTINUED)

FIGURE 62 TOTAL NUMBER OF PATENTS BY COMPANY FOR DEVICES, 2005-2007

PATENTS BY ASSIGNEE

TABLE 90 NUMBER OF PATENTS BY ASSIGNEE FOR DEVICES, 2005-2007

FIGURE 63 NUMBER OF PATENTS BY ASSIGNEE FOR DEVICES, 2005-2007

COMPANY PROFILES FOR DIAGNOSTICS ABBOTT LABORATORIES INC AXIS-SHIELD PLC BAYER AG BECKMAN COULTER INC BIOMÉRIEUX INC BIOSITE INCORPORATED BIOSOUND ESAOTE INC CAMBRIDGE HEART INC. CHOLESTECH COVIDIEN DADE BEHRING INC DELTEX MEDICAL GROUP PLC EPIX PHARMACEUTICALS, INC. EP MEDSYSTEMS FONAR CORPORATION GE HEALTHCARE HYPERTENSION DIAGNOSTIC INC. INVERNESS MEDICAL INNOVATIONS, INC MALLINCKRODT MEDISON AMERICA INC MORTARA INSTRUMENT INC OLYMPUS AMERICA INC. ORTHO-CLINICAL DIAGNOSTICS, INC. (JOHNSON & JOHNSON CO.) PHILIPS MEDICAL SYSTEM PREMD INC RESPONSE BIOMEDICAL CORP. ROCHE HOLDING SIEMENS SONOSITE SONOSITE (CONTINUED) COMPANY PROFILES FOR DRUGS ABBOTT LABORATORIES INC ASTRAZENECA PLC BAYER HEALTHCARE PHARMACEUTICALS INC. BIOVAIL CORPORATION BOEHRINGER INGELHEIM BRISTOL-MYERS SQUIBB COMPANY CV THERAPEUTICS INC HOFFMAN-LA ROCHE INC. KRKA GROUP LES LABORATORIES SERVIER MERCK & CO. INC. MERCK KGAA NOVARTIS AG PFIZER INC SANOFI AVENTIS SCHERING PLOUGH SOLVAY S.A. UCB WYETH ZENTIVA N.V.

COMPANY PROFILES FOR DEVICES AMBU INTERNATIONAL AS ANGIODYNAMICS INC ASAHI INTECC CO., LTD. ATS MEDICAL INC BACCHUS VASCULAR BIOHEART INC BIOSENSOR INTERNATIONAL GROUP BOSTON SCIENTIFIC CORPORATION CARDIMA INC CONOR MEDSYSTEMS, LLC COOK GROUP CORDIS CORPORATION (JOHNSON &JOHNSON CO.) COREVALVE C.R. BARD INC CRYOCATH CRYOCOR DATASCOPE CORP. EDWARD LIFESCIENCES CORP. GOODMAN CO. LTD HANSEN MEDICAL HOSPIRA JAPAN LIFELINE MEDTRONIC MERIT MEDICAL SYSTEM INC. NMT MEDICAL INC. POSSIS MEDICAL SORIN GROUP ST.JUDE MEDICAL TERUMO THORATEC VASCULAR SOLUTIONS INC WORLD HEART CORP ZOLL MEDICAL INC.

APPENDIX

TABLE 91 ACRONYMS

TABLE 91 (CONTINUED)

LIST OF TABLES

SUMMARY TABLE WORLDWIDE REVENUE OF CARDIOVASCULAR DIAGNOSTICS, DRUGS, AND DEVICES, THROUGH 2012 ($ BILLIONS)

TABLE 1 PREVALENCE OF STROKE, MYOCARDIAL INFARCTION, AND ANGINA PECTORIS BY VARIOUS CATEGORIES, 2005

TABLE 2 PREVALENCE OF CARDIOVASCULAR DISEASES IN U.S., 2005 (MILLION PEOPLE)

TABLE 3 COST OF CARDIOVASCULAR DISEASES IN U.S. THROUGH 2012 ($ BILLIONS)

TABLE 4 MORTALITY DUE TO CARDIOVASCULAR DISEASES IN THE U.S., 2005 (%)

TABLE 5 MORTALITY DUE TO CARDIOVASCULAR DISEASES IN EUROPE, 2005 (%)

TABLE 6 CARDIOVASCULAR DRUGS APPROVED BY FDA, 2002-2007*

TABLE 7 CARDIOVASCULAR DEVICES APPROVED BY THE FDA, 2002-2007*

TABLE 8 CARDIOVASCULAR DRUGS RECALLED BY THE FDA, 2002-2007*

TABLE 9 CARDIOVASCULAR DEVICES RECALLED BY THE FDA, 2002-2007*

TABLE 10 NT-PROBNP IN ACUTE SITUATIONS

TABLE 11 NT-PROBNP IN PRIMARY CARE SETTING

TABLE 12 ADVANTAGES OF POINT OF CARE TESTING

TABLE 13 DISADVANTAGES OF POINT OF CARE TESTING

TABLE 14 VENUES FOR POC TESTING

TABLE 15 TYPES OF ECHOCARDIOGRAMS

TABLE 16 TYPES OF DOPPLER ULTRASOUND

TABLE 17 COMMONLY USED ANTI-ANGINAL AGENTS

TABLE 18 COMMONLY USED ANTI-ARRHYTHMIC AGENTS

TABLE 19 COMMONLY USED ANTI-HYPERTENSIVE AGENTS

TABLE 20 COMMONLY USED BLOOD LIPID LOWERING AGENTS

TABLE 21 COMMONLY USED DRUGS TO TREAT CONGESTIVE HEART FAILURE

TABLE 22 PACEMAKERS

TABLE 23 PRESENT CARDIAC MARKER TESTING

TABLE 24 MARKET SHARE OF COMPANIES PROVIDING BIOMARKER TESTS, 2006 (%)

TABLE 25 PRESENT POINT-OF-CARE TESTING FOR CARDIAC BIOMARKERS

TABLE 26 MARKET SHARE OF COMPANIES PROVIDING POINT-OFCARE TESTING FOR CARDIAC BIOMARKERS, 2006 (%)

TABLE 27 PRESENT IMAGING SYSTEMS FOR IN-VIVO DIAGNOSIS

TABLE 28 MARKET SHARE OF COMPANIES PROVIDING IN-VIVO DIAGNOSTICS, 2006 (%)

TABLE 29 GLOBAL MARKET LEADERS OF ANTI-ANGINAL AGENTS

TABLE 30 MARKET SHARE OF COMPANIES MANUFACTURING ANTIANGINAL AGENTS, 2006 (%)

TABLE 31 GLOBAL MARKET LEADERS OF ANTI-ARRHYTHMIC AGENTS

TABLE 32 MARKET SHARE OF COMPANIES MANUFACTURING ANTIARRHYTHMIC AGENTS, 2006 (%)

TABLE 33 GLOBAL MARKET LEADERS OF ANTI-HYPERTENSIVE AGENTS

TABLE 34 MARKET SHARE OF COMPANIES MANUFACTURING ANTIHYPERTENSIVE AGENTS, 2006 (%)

TABLE 35 GLOBAL MARKET LEADERS OF ANTI-THROMBOTIC AGENTS

TABLE 36 MARKET SHARE OF COMPANIES MANUFACTURING ANTITHROMBOTIC AGENTS, 2006 (%)

TABLE 37 GLOBAL MARKET LEADERS OF BLOOD LIPID LOWERING AGENTS

TABLE 38 MARKET SHARE OF COMPANIES MANUFACTURING BLOOD LIPID LOWERING AGENTS, 2006 (%)

TABLE 39 GLOBAL MARKET LEADERS OF DRUGS TREATING CONGESTIVE HEART FAILURE

TABLE 40 MARKET SHARE OF COMPANIES MANUFACTURING DRUGS TREATING CONGESTIVE HEART FAILURE, 2006 (%)

TABLE 41 GLOBAL MARKET LEADERS OF MANUFACTURERS OF PACEMAKERS

TABLE 42 MARKET SHARE OF COMPANIES MANUFACTURING PACEMAKERS, 2006 (%)

TABLE 43 GLOBAL MARKET LEADERS OF MANUFACTURERS OF CONVENTIONAL CARDIOVERTER DEFIBRILLATORS

TABLE 44 GLOBAL MARKET LEADERS OF MANUFACTURERS OF CRTDEFIBRILLATORS

TABLE 45 MARKET SHARE OF COMPANIES MANUFACTURING CONVENTIONAL CARDIOVERTER DEFIBRILLATORS, 2006 (%)

TABLE 46 MARKET SHARE OF COMPANIES MANUFACTURING CRTDEFIBRILLATORS, 2006 (%)