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Organ and Tissue Transplantation and Alternatives

  • March 2015
  • -
  • BCC Research
  • -
  • 196 pages

REPORT HIGHLIGHTS

The global market for organ and tissue transplantation products and devices reached $55.6 billion in 2014. This market is estimated to grow at a compound annual growth rate (CAGR) of 6.8% to reach $62.9 billion by 2015 and $88.1 billion by 2020.

This report provides:
An overview of the global markets for organ and tissue transplantation and alternatives.
Analyses of global market trends, with data from 2014, estimates for 2015 and projections of CAGR through 2020.
Detailed examination of procurement and preservation, solid organ transplantation, tissue transplantation, immunosuppressives and other pharmaceuticals, post-transplantation concerns, as well as alternatives to transplantation.
Coverage of post-transplant immunosuppression and monitoring methods and post-transplant drug regimens and patient and graft survival rates.
In-depth analysis of the market's dynamics, specifically growth drivers, inhibitors, and opportunities
Comprehensive profiles of major players in the industry.

SCOPE OF REPORT

This report offers forecasts, by product segment, from 2015 through 2020, including supporting analyses for projections. Product segments covered consist of the solid organ (e.g., kidneys, liver, heart-lung, pancreas, intestines) and the tissue transplantation (e.g., bone, skin, cornea, heart valve) markets, along with the pharmaceuticals that accompany each market.
Also included are experimental xenografts and artificial organs; tissue transplants; and cell transplants (e.g., bone marrow, cord blood, peripheral blood, islet cell). The report touches on the use of fetal cells, stem cells and altered cancer cells.
The arrangement of this report offers an overview of the key elements in the transplantation process: tissue typing, procurement and preservation, immunosuppressants for solid organ and tissue transplants and postoperative monitoring. International markets are discussed, and information is provided on industry structure and the regulatory environment.

Within each section are discussions of commercialization opportunities for each segment of the market. New or emerging devices, techniques and pharmaceuticals are highlighted.
Profiles of more than 50 leading companies involved with solid organ transplantation, tissue transplantation, and alternative technologies are included. The report provides information on company placement within the market and strategic analyses of the companies’ available and emerging products.
An appendix featuring various terms and processes used in transplantation is provided at the end of the report.
This report cites autologous products only in relation to their impact on the market for allografts. It does not include blood products, with the exception of peripheral and umbilical cord blood as a source of stem cells.

Table Of Contents

Organ and Tissue Transplantation and Alternatives

Chapter- 1: Introduction - Complimentary 4

REASONS FOR DOING THE STUDY
STUDY GOALS AND OBJECTIVES
SCOPE OF REPORT
METHODOLOGIES AND INFORMATION SOURCES
ANALYST'S CREDENTIALS
RELATED BCC RESEARCH REPORTS
BCC RESEARCH WEBSITE
DISCLAIMER

Chapter- 2: SUMMARY 4

COST OF CARE
GLOBAL MARKET
SOLID ORGAN PRESERVATION
IMMUNOSUPPRESSION
DONATION
SOFT TISSUE MARKET
ORGAN ALTERNATIVES
GLOBAL MARKET PROJECTIONS

Chapter- 3: INDUSTRY OVERVIEW 28

HISTORY OF TRANSPLANTATION
INDUSTRY ACQUISITIONS
NECESSARY COMPONENTS TO ORGAN AND TISSUE TRANSPLANTATION
OVERVIEW OF THE DONATION PROCESS
THE TRANSPLANTATION PROCESS
SOLID ORGANS
TISSUE TRANSPLANTATION IN THE U.S.
TRANSPLANTATION TRENDS OUTSIDE THE U.S.
TRENDS IN LIVING AND CADAVERIC DONATIONS OUTSIDE THE U.S.
GLOBAL SOLID ORGAN TRANSPLANTATION
LIMITED ORGAN SUPPLY CURTAILS TRANSPLANTATIONS
KEY FACTORS IN INDUSTRY GROWTH
KEY FACTORS INHIBITING GROWTH
REGULATIONS AND REIMBURSEMENT
REGULATIONS IN THE U.S.
REGULATIONS OUTSIDE THE U.S.
REIMBURSEMENT IN THE U.S.
REIMBURSEMENT OUTSIDE THE U.S.

Chapter- 4: TISSUE TYPING TECHNOLOGIES 6

ROLE OF TISSUE TYPING IN TRANSPLANTATION
TISSUE TYPING TECHNOLOGIES
HLA ANALYSIS METHODS
GLOBAL TISSUE TYPING MARKET
REGIONAL ANALYSIS

Chapter- 5: SOLID ORGAN PROCUREMENT AND PRESERVATION 19

DEFINITION OF BRAIN DEATH
ORGANS OBTAINED FOR TRANSPLANT
INCREASING SUPPLY IN THE U.S.
THE TRANSPLANT GROWTH AND MANAGEMENT COLLABORATIVE
SUPPLY MANAGEMENT
ORGAN PROCUREMENT OUTSIDE THE U.S.
ALLOCATION CRITERIA IN THE U.S.
ALLOCATION CRITERIA IN THE EU
SOLID ORGAN PRESERVATION
GLOBAL MARKET FOR ORGAN PRESERVATION METHODS
MARKET FOR PRESERVATION SOLUTIONS
GLOBAL MARKET SHARE OF ORGAN PRESERVATION SOLUTIONS
MACHINE PERFUSION
PRESERVATION SOLUTIONS IN DEVELOPMENT

Chapter- 6: TISSUE PRODUCTS 24

GLOBAL TISSUE MARKET, BY REGION
SOFT TISSUE REPAIR AND REPLACEMENT
PROJECTED GLOBAL SOFT TISSUE MARKET, BY REGION
HEART VALVES
CORNEA
BLOOD STEM CELLS
THE ORTHOBIOLOGICS MARKET
SKIN GRAFTS
VASCULAR TISSUE TRANSPLANTATION
Table 22 : PROJECTED GLOBAL TISSUE GRAFTING MARKET, BY TISSUE TYPE THROUGH 2020

Chapter- 7: IMMUNOSUPPRESSANTS, ANTI-INFECTIVES AND POST-TRANSPLANT MONITORING 26

TOLERANCE OF TRANSPLANTED ORGANS
COMMON ANTI-REJECTION DRUG PROTOCOLS
TYPES OF IMMUNOSUPPRESSANTS
CALCINEURIN INHIBITORS
ANTI-PROLIFERATIVE AGENTS
M-TOR INHIBITORS
MONOCLONAL AND POLYCLONAL ANTIBODY PRODUCTS
T-CELL COSTIMULATION BLOCKER
TREATMENTS BY STAGE OF PROCEDURE
MAINTENANCE THERAPY
IMMUNOSUPPRESSANT USE IN PEDIATRIC TRANSPLANTATION
ADVANCES IN POST-OPERATIVE DESENSITIZATION
GLOBAL IMMUNOSUPPRESSANT MARKET
ANTI-INFECTIVES AND POST-TRANSPLANT MONITORING IN ORGAN AND TISSUE TRANSPLANTATION

Chapter- 8: ALTERNATIVE DEVICES AND TECHNOLOGIES 21

ALTERNATIVES TO HEART TRANSPLANTATION
OPPORTUNITIES IN THE ORTHOPEDIC DEVICE MARKET
MARKET LEADERS IN ORTHOPEDIC REPLACEMENTS
HIP
KNEE
SPINE
EXTREMITIES
ALTERNATIVES TO CORNEAL TRANSPLANTATION
ALTERNATIVES TO INTESTINAL TRANSPLANTATION
ALTERNATIVES TO PANCREAS TRANSPLANTATION
ALTERNATIVES TO LIVER TRANSPLANTATION
ALTERNATIVES TO VASCULAR TRANSPLANTATION
REGIONAL ANALYSIS
Table 51 : PROJECTED GLOBAL MARKET FOR TRANSPLANTATION ALTERNATIVE DEVICES, THROUGH 2020

Chapter- 9: EMERGING PROCEDURES AND PRODUCTS IN DEVELOPMENT 10

ORGAN PRESERVATION SOLUTIONS IN DEVELOPMENT
REGENERATIVE MEDICINE
STEM CELL RESEARCH
ADVANCES IN CARDIOVASCULAR TREATMENTS
IMMUNOSUPPRESSIVE AGENTS IN DEVELOPMENT
PHARMACEUTICAL PIPELINE DEVELOPMENT
EXTREMITY REPAIR/REPLACEMENT

Chapter- 10: COMPANY DIRECTORY 51

TISSUE TYPING/DIAGNOSTICS
PRESERVATION SOLUTIONS (SOLID ORGAN/CELL/TISSUE)/ TRANSPORT SYSTEMS
TRANSPLANT PHARMACEUTICALS (IMMUNOSUPPRESSANTS, POST-TRANSPLANT PHARMACEUTICALS)
MECHANICAL HEART IMPLANTS
HEART VALVES
JOINT/ORTHOPEDIC IMPLANTS
TISSUE/BONE REGENERATIVE PRODUCTS

Chapter- 11: APPENDIX 3

Table 67 : DEFINITIONS

List of Tables

Summary Table : PROJECTED GLOBAL MARKET FOR TRANSPLANTATION PRODUCTS AND DEVICES, THROUGH 2020
Table 1 : TIMELINE OF ORGAN TRANSPLANTATION HISTORY, 1900-2012
Table 2 : SELECTED TRANSPLANT INDUSTRY ACQUISITIONS, 2010-EARLY 2015
Table 3 : U.S. ORGAN/TISSUE TRANSPLANTS: AVERAGE FIRST YEAR COST, ESTIMATED NUMBER OF PROCEDURES, AND VALUE BY TYPE OF ORGAN TRANSPLANT, 2011
Table 4 : ORGAN DONATIONS IN EUROPE, BY TYPE, 2012-2013
Table 5 : GLOBAL ACTIVITY IN ORGAN TRANSPLANTATION, 2012
Table 6 : U.S. GRAFT SURVIVAL RATES, BY ORGAN AND YEARS
Table 7 : IMMUNOSUPPRESSIVE DRUGS CURRENTLY COVERED BY MEDICARE*
Table 8 : OVERVIEW OF MEDICARE IMMUNOSUPPRESSIVE DRUG COVERAGE
Table 9 : TISSUE TYPING TECHNOLOGIES
Table 10 : PROJECTED GLOBAL MARKET FOR TISSUE TYPING, THROUGH 2020
Table 11 : PROJECTED GLOBAL TISSUE TYPING MARKET, BY REGION, THROUGH 2020
Table 12 : U.S. ORGAN RECIPIENTS WHO PREVIOUSLY HAD A TRANSPLANT: ALL ORGANS, 2007-2013
Table 13 : PERCENT OF U.S. ORGAN DISCARDS, BY TYPE, 2012
Table 14 : MEDIAN U.S. WAITLIST TIME FOR POTENTIAL RECIPIENTS, BY ORGAN AND NUMBER OF MONTHS, 2008
Table 15 : COLD ISCHEMIA TIME FOR TRANSPLANTED ORGANS
Table 16 : PROJECTED GLOBAL MARKET FOR ORGAN PRESERVATION METHODS, THROUGH 2020
Table 17 : OPTIMAL PRESERVATION SOLUTION DESIGN
Table 18 : MAJOR ORGAN PRESERVATION SOLUTIONS
Table 19 : PROJECTED GLOBAL MARKET FOR SOLID ORGAN PRESERVATION SOLUTIONS (NOT INCLUDING THE PAPWORTH COCKTAIL) BY GEOGRAPHIC REGION, THROUGH 2020
Table 20 : ADVANTAGES AND DISADVANTAGES OF MACHINE PERFUSION
Table 21 : PROJECTED GLOBAL MARKET FOR MACHINE PERFUSION /ORGAN TRANSPORT SYSTEMS, THROUGH 2020
Table 22 : PROJECTED GLOBAL TISSUE GRAFTING MARKET, BY TISSUE TYPE THROUGH 2020
Table 23 : PROJECTED GROWTH IN TISSUE MARKET REVENUES, BY REGION, THROUGH 2020
Table 24 : CARTILAGE AND SOFT TISSUE BIOLOGICS AND BIOMATERIALS
Table 25 : PROJECTED GLOBAL MARKET FOR SOFT TISSUE REPAIR AND REPLACEMENT, THROUGH 2020
Table 26 : PROJECTED GLOBAL MARKET FOR SOFT TISSUE REPAIR AND REPLACEMENT, BY REGION, THROUGH 2020
Table 27 : GLOBAL HEART VALVE MARKET, THROUGH 2020
Table 28 : PROJECTED GLOBAL MARKET FOR HEART VALVES, BY REGION, THROUGH 2020
Table 29 : PROJECTED GLOBAL GROWTH OF CORNEAL TRANSPLANT MARKET, THROUGH 2020*
Table 30 : PROJECTED GLOBAL MARKET FOR BLOOD STEM CELL TRANSPLANTATION, THROUGH 2020
Table 31 : PROJECTED GLOBAL MARKET FOR ORTHOBIOLOGICAL PRODUCTS, THROUGH 2020*
Table 32 : HUMAN BONE PRODUCTS AND MARKETERS
Table 33 : SYNTHETIC BONE-REPLACEMENT PRODUCTS AND MARKETERS
Table 34 : PROJECTED GLOBAL GROWTH OF SKIN GRAFTS, THROUGH 2020
Table 35 : PROJECTED GLOBAL VASCULAR TISSUE TRANSPLANTATION MARKET, THROUGH 2020
Table 36 : PROJECTED GLOBAL MARKET FOR IMMUNOSUPPRESSANTS USED IN TRANSPLANTS, BY TYPE, THROUGH 2020
Table 37 : IMMUNOSUPPRESSANT DRUGS APPROVED IN THE U.S., THE EU, AND JAPAN, THROUGH 2014
Table 38 : IMMUNOSUPPRESSANTS BY DRUG CLASS, GENERIC NAME, BRAND NAME, AND MANUFACTURER
Table 39 : GLOBAL MARKET FOR CALCINEURIN INHIBITORS TO TREAT ORGAN TRANSPLANT REJECTION, THROUGH 2020
Table 40 : GLOBAL MARKET FOR ANTI-PROLIFERATIVE AGENTS TO TREAT ORGAN TRANSPLANT REJECTION, THROUGH 2020
Table 41 : PROJECTED GLOBAL MARKET FOR M-TOR INHIBITORS TO TREAT ORGAN TRANSPLANT REJECTION, THROUGH 2020
Table 42 : ANTIBODY PRODUCTS FOR TREATMENT OF ORGAN TRANSPLANT REJECTION
Table 43 : PROJECTED GLOBAL MARKET FOR POLYCLONAL ANTIBODY PRODUCTS, THROUGH 2020
Table 44 : PROJECTED GLOBAL MARKET FOR T-CELL COSTIMULATION BLOCKERS, THROUGH 2020
Table 45 : IMMUNOSUPPRESSANT USE FOR INDUCTION BY ORGAN IN U.S., 2012*
Table 46 : IMMUNOSUPPRESSANT USE FOR MAINTENANCE (UP TO 2 YEARS POST-TRANSPLANT) BY ORGAN, 2010*
Table 47 : PROJECTED GLOBAL MARKET FOR IMMUNOSUPPRESSANTS, BY REGION, THROUGH 2020
Table 48 : COMMON ANTI-INFECTIVE AND IMMUNOSUPPRESSANT AGENTS AND INTERACTIONS, 2012*
Table 49 : POST-TRANSPLANT INFECTIONS BY TYPE OF TRANSPLANT, WITH COMMON TIME FRAMES FOR INFECTION
Table 50 : RECOMMENDED POST-TRANSPLANT CARE, 2012
Table 51 : PROJECTED GLOBAL MARKET FOR TRANSPLANTATION ALTERNATIVE DEVICES, THROUGH 2020
Table 52 : GLOBAL MARKET FOR ARTIFICIAL HEART DEVICES, THROUGH 2020
Table 53 : GLOBAL MARKET FOR TOTAL ARTIFICIAL HEARTS, THROUGH 2020
Table 54 : GLOBAL MARKET FOR VADS, THROUGH 2020
Table 55 : SELECTED GLOBAL COMMERCIAL OPPORTUNITIES FOR NEW DEVICES IN THE FUTURE
Table 56 : PROJECTED GLOBAL MARKET FOR ORTHOPEDIC DEVICES USED IN TRANSPLANTATION, THROUGH 2020
Table 57 : PROJECTED GLOBAL MARKET FOR HIP REPLACEMENTS, THROUGH 2020
Table 58 : PROJECTED GLOBAL MARKET FOR KNEE REPLACEMENTS, THROUGH 2020
Table 59 : PROJECTED GLOBAL MARKET FOR SPINAL RECONSTRUCTIVE PRODUCTS, THROUGH 2020
Table 60 : PROJECTED GLOBAL MARKET FOR EXTREMITY REPAIR/REPLACEMENTS, THROUGH 2020
Table 61 : THERAPEUTIC INDICATIONS FOR PTK
Table 62 : INDICATIONS FOR BIOARTIFICIAL LIVER TRANSPLANTATION
Table 63 : PROJECTED GLOBAL MARKET FOR ORTHOPEDIC AND CARDIAC ALTERNATIVE THERAPIES, BY REGION, THROUGH 2020
Table 64 : TYPES OF REGENERATIVE CELLULAR THERAPIES
Table 65 : SELECTED IMMUNOSUPPRESSIVE AGENTS IN DEVELOPMENT, 2015
Table 66 : PHARMACEUTICAL PIPELINE/DEVICE BY MANUFACTURER, TYPE OF PRODUCT, INDICATIONS FOR USE, AND STAGE OF CLINICAL TESTING
Table 67 : DEFINITIONS

List of Figures

Summary Figure : PROJECTED GLOBAL MARKET SHARE OF TRANSPLANTATION PRODUCTS AND DEVICES, 2015 AND 2020
Figure 1 : GLOBAL MARKET SHARES IN TISSUE TYPING TECHNOLOGIES BY MARKET LEADER, 2014
Figure 2 : GLOBAL MARKET SHARE OF ORGAN PRESERVATION SOLUTIONS 2013
Figure 3 : GLOBAL TISSUE MARKET SHARES BY REGION, 2015 AND 2020
Figure 4 : GLOBAL SOFT TISSUE MARKET, BY REGION, IN 2015 AND 2020
Figure 5 : LEADING HEART VALVE SUPPLIERS, 2014
Figure 6 : PROJECTED GLOBAL MARKET SHARES OF IMMUNOSUPPRESSIVES BY TYPE, THROUGH 2020
Figure 7 : PROJECTED GLOBAL MARKET FOR IMMUNOSUPPRESSANTS, BY REGION, 2015 AND 2020
Figure 8 : GLOBAL MARKET FOR ORTHOPEDIC DEVICES, BY TYPE, 2015 AND 2020
Figure 9 : ORTHOPEDIC REPLACEMENT DEVICE MARKET, BY COMPANY MARKET SHARE, 2014
Figure 10 : GLOBAL MARKET SHARES OF THE SPINAL RECONSTRUCTION MARKET BY COMPANY, 2013
Figure 11 : PROJECTED GLOBAL MARKET FOR ORTHOPEDIC IMPLANT PRODUCTS, BY REGION, 2015 AND 2020

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