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Excipients in Pharmaceuticals

  • March 2016
  • -
  • BCC Research
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  • 158 pages

This BCC Research study provides an overview of the current and future global market for pharmaceutical excipients. It explores present and future strategies within the market as well as innovations in the market, hold ups and needs. Forecast provided for the period 2015-2020.

This BCC Research report discusses AD disease related events, etiology and epidemiology of AD by providing information on prevalence and incidence rates, diagnostic tools and equipment, and by introducing important scientific and technological frameworks in the global market for AD therapeutics and diagnostics. Forecast provided through 2020.

Use this report to:

Analyze the areas of market growth in pharmaceutical excipients manufacturing.
Provide an overview of the current and future characteristics of the global market for pharmaceutical excipients.
Discuss the strengths and weakness of each type of excipient in light of the new technologies, growing competition, and changing customer needs.

Highlights

The global excipients market should reach nearly $6.9 billion by 2020 from over $6.2 billion in 2015, a compound annual growth rate (CAGR) of 1.9% from 2015 to 2020.
The organic excipients market should reach $6.3 billion by 2020 from nearly $5.8 billion in 2015, a CAGR of 1.7% from 2015 to 2020.
The inorganic excipients market should reach $433.7 million by 2020 from $351.9 million in 2015, a CAGR of 4.3% from 2015 to 2020.

STUDY OBJECTIVES


Pharmaceutical excipients are natural or synthetic ingredients used along with the active ingredient in a drug formulation. Pharmaceutical excipients are used as fillers and diluents, binders, suspension and viscosity agents, coatings, flavoring agents, disintegrants, colorants, lubricants and glidants and preservatives. Excipients are categorized into three main classes, organic excipients, inorganic excipients and USP water (purified water produced per United States Pharmacopeia {USP} standards).

BCC’s goal in conducting this study is to provide an overview of the current and future global market for pharmaceutical excipients. This report explores present and future strategies within the market as well as innovations in the market, hold ups and needs.

The classifications, comparisons and usage of these products are also discussed.

A detailed analysis of the pharmaceutical excipients industry structure has been conducted. Revenues are broken down by region. Sales figures are estimated for the five-year period from 2015 through 2020. The report also covers significant patents and their allotments in each category.

REASONS FOR DOING THIS STUDY

Excipients are an integral part of the pharmaceutical industry. Advancements in pharmaceutical science and technology have led to the availability of a wide range of excipients for drug formulation and development. The introduction of new excipients with technologies like nanotechnology and spray drying has helped to bring important changes to the excipients market. Extensive research in the field of pharmaceutical excipients analysis shows their use in developing efficient products.

R&D spending, along with increasing competition, patent expiries and new technologies are giving new direction to the market. Advancements, new product launches and modern technologies will influence market growth in the future. This study looks at almost all the systems affected by these factors.

Acquisition strategies and collaborations by companies are also covered in this report. This study discusses the strength and weaknesses of each type of excipients in light of new technologies, growing competition, and changing customer needs.

Table Of Contents

Excipients in Pharmaceuticals
CHAPTER 1 INTRODUCTION 2
STUDY OBJECTIVES 2
REASONS FOR DOING THIS STUDY 2
CONTRIBUTIONS OF THE STUDY AND INTENDED AUDIENCE 2
SCOPE OF THE STUDY 3
METHODOLOGY 3
INFORMATION SOURCES 3
ANALYSTS' CREDENTIALS 3
RELATED BCC RESEARCH REPORTS 4
BCC RESEARCH WEBSITE 4
DISCLAIMER 4
CHAPTER 2 EXECUTIVE SUMMARY 7
SUMMARY TABLE GLOBAL EXCIPIENT MARKET BY MATERIAL TYPE, THROUGH 2020
($ MILLIONS) 7
SUMMARY FIGURE GLOBAL EXCIPIENT MARKET BY MATERIAL TYPE, 2013-2020 ($
MILLIONS) 7
CHAPTER 3 OVERVIEW 10
DEFINITIONS 10
WHAT AN EXCIPIENT IS 11
PHARMACEUTICAL EXCIPIENTS 11
EXCIPIENT SELECTION 11
TABLE 1 CHARACTERISTICS CONSIDERED FOR EXCIPIENT SELECTION 11
TABLE 2 CHARACTERISTICS OF AN IDEAL EXCIPIENT 12
EXCIPIENT INTERACTIONS 12
DRUG-EXCIPIENT INTERACTIONS 13
Physical Interactions 13
TABLE 3 TYPES OF PHYSICAL INTERACTIONS 13
Chemical Interactions 13
TABLE 4 TYPES OF CHEMICAL INTERACTIONS 14
Biopharmaceutical Interactions 15
EXCIPIENT-EXCIPIENT INTERACTION 16
Co-processed Excipient 16
PACKAGE-EXCIPIENT INTERACTIONS 16
TABLE 5 PACKAGE-EXCIPIENT INTERACTIONS 17
CLASSIFICATION OF PHARMACEUTICAL EXCIPIENTS 18
MATERIAL TYPE 18
Organic Chemicals 18
Inorganic Chemicals 19
USP Water 19
FUNCTIONAL USE 19
Solid Dosage Forms 19
Liquid Dosage Forms 19
Semi-solid Dosage Forms 19
Therapeutic Usage 20
TABLE 6 SOME EXCIPIENTS AND THEIR THERAPEUTIC FUNCTIONS 20
DELIVERY SYSTEMS 20
Injectables 20
Oral Delivery Systems 20
Topical Delivery Systems 21
Advanced Delivery Systems 22
Cyclodextrins 22
Polysaccharides 22
Implants 22
Liposomes 23
Microspheres 23
Microparticles 23
Nanoparticles 23
Protein-coated Microcrystals (PCMCs) 24
Osmotic Pump Systems 24
Transdermal Drug Delivery 24
Single Layer Drug in Adhesive 25
Multi Layer Drug in Adhesive 25
Reservoir 25
Matrix. 25
Vapor Patch 25
Transmucosal delivery 25
GLOBAL HEALTHCARE TRENDS 26
GLOBAL INNOVATION 26
AGEING WORKFORCE AND POPULATION 26
REGULATION AND TAXATION 26
EDUCATION 27
RandD FUNDING AND CONCENTRATION 27
DECLINING BARRIERS FOR ENTREPRENEURS 27
DIFFERENCES IN LABOR PRODUCTIVITY 27
CHAPTER 4 REGULATORY AND NEW DEVELOPMENTS 29
RECENT DEVELOPMENTS IN THE PHARMACEUTICAL EXCIPIENTS INDUSTRY
(2014 TO 2015) 29
TABLE 7 NEW PRODUCTS LAUNCHED, 2014 AND 2015 36
MERGERS AND ACQUISITIONS 37
TABLE 8 MERGERS AND ACQUISITIONS, 2014-2015 38
CHAPTER 5 MARKET ANALYSIS 43
MARKET SIZE 44
TABLE 9 GLOBAL EXCIPIENT MARKET BY MATERIAL TYPE, THROUGH 2020 ($
MILLIONS) 44
FIGURE 1 GLOBAL EXCIPIENT MARKET BY MATERIAL TYPE, 2013-2020 ($ MILLIONS) 45
ORGANIC CHEMICALS 45
MARKET SIZE 46
TABLE 10 GLOBAL ORGANIC CHEMICAL EXCIPIENT MARKET BY MATERIAL TYPE,
THROUGH 2020 ($ MILLIONS) 47
FIGURE 2 GLOBAL ORGANIC CHEMICAL EXCIPIENT MARKET BY MATERIAL TYPE,
2013-2020 ($ MILLIONS) 47
CARBOHYDRATES 48
TABLE 11 GLOBAL CARBOHYDRATE EXCIPIENT MARKET BY TYPE, THROUGH 2020
($ MILLIONS) 48
FIGURE 3 GLOBAL CARBOHYDRATE EXCIPIENT MARKET BY TYPE, 2013-2020 ($
MILLIONS) 48
CELLULOSE 49
TABLE 12 GLOBAL CELLULOSE EXCIPIENT MARKET BY TYPE, THROUGH 2020 ($
MILLIONS) 51
FIGURE 4 GLOBAL CELLULOSE EXCIPIENT MARKET BY TYPE, 2013-2020 ($
MILLIONS) 51
SUGARS 52
TABLE 13 GLOBAL SUGAR EXCIPIENT MARKET BY TYPE, THROUGH 2020 ($
MILLIONS) 52
FIGURE 5 GLOBAL SUGAR EXCIPIENT MARKET BY TYPE, 2013-2020 ($ MILLIONS) 52
Actual Sugars 53
TABLE 14 GLOBAL ACTUAL SUGARS EXCIPIENT MARKET BY TYPE, THROUGH 2020
($ MILLIONS) 54
FIGURE 6 GLOBAL ACTUAL SUGAR EXCIPIENT MARKET BY TYPE, 2013-2020 ($
MILLIONS) 54
Sugar Alcohols (Polyols) 55
TABLE 15 GLOBAL SUGAR ALCOHOL (POLYOL) EXCIPIENT MARKET BY TYPE,
THROUGH 2020 ($ MILLIONS) 55
FIGURE 7 GLOBAL SUGAR ALCOHOL (POLYOL) EXCIPIENT MARKET BY TYPE,
2013-2020 ($ MILLIONS) 55
Artificial Sweeteners 56
TABLE 16 GLOBAL ARTIFICIAL SWEETENER EXCIPIENT MARKET, THROUGH 2020 ($
MILLIONS) 56
FIGURE 8 GLOBAL ARTIFICIAL SWEETENER EXCIPIENT MARKET, 2013-2020 ($
MILLIONS) 56
STARCHES 57
TABLE 17 GLOBAL STARCHES EXCIPIENT MARKET BY TYPE, THROUGH 2020 ($
MILLIONS) 59
FIGURE 9 GLOBAL STARCHES EXCIPIENT MARKET BY TYPE, 2013-2020 ($ MILLIONS) 59
PETROCHEMICALS 60
TABLE 18 GLOBAL PETROCHEMICAL EXCIPIENT MARKET BY TYPE, THROUGH 2020
($ MILLIONS) 61
FIGURE 10 GLOBAL PETROCHEMICAL EXCIPIENT MARKET BY TYPE, 2013-2020 ($
MILLIONS) 61
GLYCOLS 62
TABLE 19 GLOBAL GLYCOL EXCIPIENT MARKET BY TYPE, THROUGH 2020 ($
MILLIONS) 63
FIGURE 11 GLOBAL GLYCOL EXCIPIENT MARKET BY TYPE, 2013-2020 ($ MILLIONS) 63
MINERAL HYDROCARBONS 64
TABLE 20 GLOBAL MINERAL HYDROCARBON EXCIPIENT MARKET BY TYPE,
THROUGH 2020 ($ MILLIONS) 65
FIGURE 12 GLOBAL MINERAL HYDROCARBON EXCIPIENT MARKET BY TYPE,
2013-2020 ($ MILLIONS) 65
OLEOCHEMICALS 65
TABLE 21 GLOBAL OLEOCHEMICAL EXCIPIENT MARKET BY TYPE, THROUGH 2020 ($
MILLIONS) 68
FIGURE 13 GLOBAL OLEOCHEMICAL EXCIPIENT MARKET BY TYPE, 2013-2020 ($
MILLIONS) 68
PROTEINS 68
TABLE 22 GLOBAL PROTEINS (GELATIN) EXCIPIENT MARKET, THROUGH 2020 ($
MILLIONS) 70
FIGURE 14 GLOBAL PROTEINS (GELATIN) EXCIPIENT MARKET, 2013-2020 ($
MILLIONS) 70
OTHER ORGANIC CHEMICALS 70
TABLE 23 GLOBAL OTHER ORGANIC CHEMICAL EXCIPIENT MARKET, THROUGH
2020 ($ MILLIONS) 72
FIGURE 15 GLOBAL OTHER ORGANIC CHEMICAL EXCIPIENT MARKET, 2013-2020 ($
MILLIONS) 72
INORGANIC EXCIPIENTS 72
MARKET SIZE 73
TABLE 24 GLOBAL INORGANIC CHEMICAL EXCIPIENT MARKET BY TYPE, THROUGH
2020 ($ MILLIONS) 73
FIGURE 16 GLOBAL INORGANIC CHEMICAL EXCIPIENT MARKET BY TYPE, 2013-2020
($ MILLIONS) 73
CALCIUM SALTS 74
TABLE 25 GLOBAL CALCIUM SALTS EXCIPIENT MARKET BY TYPE, THROUGH 2020 ($
MILLIONS) 75
FIGURE 17 GLOBAL CALCIUM SALTS EXCIPIENT MARKET BY TYPE, 2013-2020 ($
MILLIONS) 75
HALITES 76
TABLE 26 GLOBAL HALITES MARKET, THROUGH 2020 ($ MILLIONS) 76
FIGURE 18 GLOBAL HALITE MARKET, 2013-2020 ($ MILLIONS) 76
METAL OXIDES 77
TABLE 27 GLOBAL METAL OXIDES EXCIPIENT MARKET BY TYPE, THROUGH 2020 ($
MILLIONS) 78
FIGURE 19 GLOBAL METAL OXIDES EXCIPIENT MARKET BY TYPE, 2013-2020 ($
MILLIONS) 78
SILICATES 78
TABLE 28 GLOBAL SILICATES EXCIPIENT MARKET BY TYPE, THROUGH 2020 ($
MILLIONS) 79
FIGURE 20 GLOBAL SILICATES EXCIPIENT MARKET BY TYPE, 2013-2020 ($
MILLIONS) 79
OTHER INORGANIC EXCIPIENTS 80
TABLE 29 GLOBAL OTHER INORGANIC EXCIPIENTS MARKET BY TYPE, THROUGH
2020 ($ MILLIONS) 81
FIGURE 21 GLOBAL OTHER INORGANIC EXCIPIENTS MARKET BY TYPE, 2013-2020
($ MILLIONS) 81
USP WATER (PHARMACEUTICAL WATER) 81
MARKET SIZE 82
TABLE 30 GLOBAL USP WATER EXCIPIENT MARKET BY TYPE, THROUGH 2020 ($
MILLIONS) 83
FIGURE 22 GLOBAL USP WATER EXCIPIENT MARKET BY TYPE, 2013-2020 ($
MILLIONS) 83
MARKET BY FUNCTIONAL USES 83
TABLE 31 GLOBAL EXCIPIENT FUNCTIONAL USES MARKET BY TYPE, THROUGH
2020 ($ MILLIONS) 85
FIGURE 23 GLOBAL EXCIPIENT FUNCTIONAL USES MARKET BY TYPE, 2013-2020 ($
MILLIONS) 85
EMOLLIENTS 85
Market Size 86
TABLE 32 GLOBAL EMOLLIENTS EXCIPIENT MARKET BY MATERIAL, THROUGH 2020
($ MILLIONS) 86
FIGURE 24 GLOBAL EMOLLIENTS EXCIPIENT MARKET BY MATERIAL, 2013-2020 ($
MILLIONS) 86
FILLERS 87
Market Size 87
TABLE 33 GLOBAL EXCIPIENT FILLER MARKET BY TYPE, THROUGH 2020 ($
MILLIONS) 88
FIGURE 25 GLOBAL EXCIPIENT FILLER MARKET BY TYPE, 2013-2020 ($ MILLIONS) 88
VEHICLES 88
Market Size 89
TABLE 34 GLOBAL VEHICLE EXCIPIENT MARKET BY TYPE, THROUGH 2020 ($
MILLIONS) 89
FIGURE 26 GLOBAL VEHICLE EXCIPIENT MARKET BY TYPE, 2013-2020 ($ MILLIONS) 89
COATINGS 90
Market Size 90
TABLE 35 GLOBAL COATINGS EXCIPIENT MARKET BY TYPE, THROUGH 2020 ($
MILLIONS) 91
FIGURE 27 GLOBAL COATINGS EXCIPIENT MARKET BY TYPE, 2013-2020 ($
MILLIONS) 91
DISINTEGRANTS 92
Market Size 93
TABLE 36 GLOBAL SUPERDISINTEGRANT EXCIPIENT MARKET BY TYPE, THROUGH
2020 ($ MILLIONS) 93
FIGURE 28 GLOBAL SUPERDISINTEGRANT EXCIPIENT MARKET BY TYPE, 2013-2020
($ MILLIONS) 93
FLAVORS 94
Market Size 94
TABLE 37 GLOBAL FLAVORS EXCIPIENT MARKET BY TYPE, THROUGH 2020 ($
MILLIONS) 94
FIGURE 29 GLOBAL FLAVORS EXCIPIENT MARKET BY TYPE, 2013-2020 ($ MILLIONS) 94
COLORANTS 95
Market Size 95
TABLE 38 GLOBAL COLORANT EXCIPIENT MARKET BY TYPE, THROUGH 2020 ($
MILLIONS) 96
FIGURE 30 GLOBAL COLORANT EXCIPIENT MARKET BY TYPE, 2013-2020 ($
MILLIONS) 96
OTHER EXCIPIENT FUNCTIONS 96
CHAPTER 6 INDUSTRY STRUCTURE 100
ORGANIC EXCIPIENTS 100
CARBOHYDRATE SUPPLIERS 100
TABLE 39 MAJOR SUPPLIERS OF CARBOHYDRATE EXCIPIENTS, 2015 100
Market Share 101
TABLE 40 GLOBAL MARKET SHARE OF MAJOR CARBOHYDRATES SUPPLIERS, 2015
(%) 101
FIGURE 31 GLOBAL MARKET SHARE OF MAJOR CARBOHYDRATES SUPPLIERS, 2015
(%) 102
PETROCHEMICAL SUPPLIERS 103
TABLE 41 MAJOR SUPPLIERS OF PETROCHEMICAL EXCIPIENTS, 2015 103
Market Share 103
TABLE 42 GLOBAL MARKET SHARE OF MAJOR PETROCHEMICAL SUPPLIERS, 2015
(%) 104
FIGURE 32 GLOBAL MARKET SHARE OF MAJOR PETROCHEMICAL SUPPLIERS, 2015
(%) 104
OLEOCHEMICAL, PROTEINS AND OTHER EXCIPIENTS SUPPLIERS 104
TABLE 43 MAJOR SUPPLIERS OF OLEOCHEMICALS, PROTEINS AND OTHER
EXCIPIENTS, 2015 105
Market Share 105
TABLE 44 GLOBAL MARKET SHARE OF MAJOR OLEOCHEMICAL SUPPLIERS, 2015 (%) 106
FIGURE 33 GLOBAL MARKET SHARE OF MAJOR OLEOCHEMICAL SUPPLIERS, 2015
(%) 106
TABLE 45 GLOBAL MARKET SHARE OF MAJOR PROTEIN SUPPLIERS, 2015 (%) 107
FIGURE 34 GLOBAL MARKET SHARE OF MAJOR PROTEIN SUPPLIERS, 2015 (%) 107
TABLE 46 GLOBAL MARKET SHARE OF MAJOR OTHER ORGANIC EXCIPIENTS
SUPPLIERS, 2015 (%) 108
FIGURE 35 GLOBAL MARKET SHARE OF MAJOR OTHER ORGANIC EXCIPIENTS
SUPPLIERS, 2015 (%) 108
INORGANIC EXCIPIENTS 108
TABLE 47 MAJOR INORGANIC EXCIPIENT SUPPLIERS, 2015 109
MARKET SHARE OF CALCIUM SALTS 109
TABLE 48 GLOBAL MARKET SHARE OF MAJOR CALCIUM SALTS SUPPLIERS, 2015 (%) 110
FIGURE 36 GLOBAL MARKET SHARE OF MAJOR CALCIUM SALTS SUPPLIERS, 2015
(%) 110
MARKET SHARE OF HALITES 110
TABLE 49 GLOBAL MARKET SHARE OF MAJOR HALITES SUPPLIERS, 2015 (%) 111
FIGURE 37 GLOBAL MARKET SHARE OF MAJOR HALITES SUPPLIERS, 2015 (%) 111
MARKET SHARE OF METAL OXIDES 111
TABLE 50 GLOBAL MARKET SHARE OF MAJOR METAL OXIDES SUPPLIERS, 2015 (%) 112
FIGURE 38 GLOBAL MARKET SHARE OF MAJOR METAL OXIDES SUPPLIERS, 2015 (%) 112
MARKET SHARE OF SILICATES 112
TABLE 51 GLOBAL MARKET SHARE OF MAJOR SILICATES SUPPLIERS, 2015 (%) 113
FIGURE 39 GLOBAL MARKET SHARE OF MAJOR SILICATES SUPPLIERS, 2015 (%) 113
MARKET SHARE OF OTHER INORGANIC CHEMICALS 113
TABLE 52 GLOBAL MARKET SHARE OF MAJOR OTHER INORGANIC EXCIPIENTS
SUPPLIERS, 2015 (%) 114
FIGURE 40 GLOBAL MARKET SHARE OF MAJOR OTHER INORGANIC EXCIPIENTS
SUPPLIERS, 2015 (%) 114
USP WATER SUPPLIERS 114
CHAPTER 7 PATENT ANALYSIS 116
PATENTS BY YEAR 116
TABLE 53 NUMBER OF PATENTS BY YEAR, 2013-OCTOBER 2015 116
FIGURE 41 NUMBER OF PATENTS BY YEAR, 2013-OCTOBER 2015 117
PATENTS BY CATEGORY 117
TABLE 54 NUMBER OF PATENTS BY CATEGORY FOR EXCIPIENTS IN THE
PHARMACEUTICAL INDUSTRY, 2013-OCTOBER 2015 117
FIGURE 42 NUMBER OF PATENTS BY CATEGORY FOR EXCIPIENTS IN THE
PHARMACEUTICAL INDUSTRY, 2013-OCTOBER 2015 117
PATENTS BY COMPANY 118
TABLE 55 NUMBER OF U.S. PATENTS FOR EXCIPIENTS BY COMPANY,
2013-OCTOBER 2015 118
PATENTS BY COUNTRY 120
TABLE 56 NUMBER OF U.S. PATENTS BY COUNTRY FOR EXCIPIENTS,
2013-OCTOBER 2015 120
TABLE 57 EXCIPIENT PATENTS BY COUNTRY, 2013-OCTOBER 2015 (NUMBER/%) 121
PATENTS BY ASSIGNEE 122
TABLE 58 NUMBER OF EXCIPIENT PATENTS BY ASSIGNEE, 2013-OCTOBER 2015 122
FIGURE 43 NUMBER OF EXCIPIENT PATENTS BY ASSIGNEE, 2013-OCTOBER 2015 122
CHAPTER 8 CURRENT SITUATION 125
CURRENT SCENARIO IN EXCIPIENTS INDUSTRY 125
REQUIREMENT OF NEW REGULATIONS 125
GDUFA RE-AUTHORIZATION 126
INAPPROPRIATE EXCIPIENT STABILITY TESTING 126
STANDARDS FOR PHARMACEUTICAL EXCIPIENTS 126
INSIGHT ON ELEMENTAL IMPURITIES 127
RAPIDLY GROWING EMERGING MARKETS 127
NANOTECHNOLOGY IN EXCIPIENTS 127
EU GUIDELINES ON GMP FOR EXCIPIENTS 128
EXCIPIENT GMP STANDARDS IMPLEMENTATION 128
DELAY OF ANDA REVIEW 128
EXCIPACT CERTIFICATION 129
TABLE 59 LIST OF COMPANIES WITH EXCIPACT CERTIFICATES 129
CHAPTER 9 COMPANY PROFILES 132
ABBOTT LABORATORIES 132
ADM 132
AKZO NOBEL 133
AMERICHEM PHARMACEUTICAL CORP. 134
ARLA FOODS A.M.B.A. 134
ASAHI KASEI CORP. 135
ASHLAND INC. 135
ASSOCIATED BRITISH FOODS PLC. 136
BASF SE 136
BAXTER INTERNATIONAL INC. 138
BLANVER FARMOQUIMICA, LTDA. 138
BRENNTAG GROUP 139
CHEMISCHE FABRIK BUDENHEIM KG 139
CABOT CORP. 140
CALUMET SPECIALTY PRODUCTS PARTNERS, LP 140
CARGILL INC. 141
COLORCON INC. 141
CORBION 142
CRISTAL GLOBAL (NATIONAL TITANIUM DIOXIDE CO. LTD.) 142
CRODA INTERNATIONAL PLC 143
CSL BEHRING LLC 143
CTD HOLDINGS INC. 144
DOW CHEMICAL CO. 144
DUPONT 145
EASTMAN CHEMICAL CO. 145
EVONIK INDUSTRIES AG 146
FERRO CORP. 146
FMC CORP. 147
FOREMOST FARMS USA 148
FUJI HEALTH SCIENCE INC. 148
GATTEFOSSEE 149
GELITA AG 149
GRAIN PROCESSING CORP. 149
GRIFOLS INTERNATIONAL S.A. 150
HILMAR CHEESE CO. INC. 150
IMERYS 151
INGREDION INC. 151
INNOPHOS INC. 152
J.M. HUBER CORP. 152
JOST CHEMICAL CO. 153
JRS PHARMA GMBH and CO. KG 153
KOSTER KEUNEN HOLLAND B.V. 154
KRONOS WORLDWIDE INC. 154
LANXESS A.G. 155
LUBRIZOL CORP. 155
LYONDELLBASELL INDUSTRIES 155
MEGGLE AG. 156
MERCK KGAA 156
MINERALS TECHNOLOGIES INC. 157
MUTCHLER INC. PHARMACEUTICAL INGREDIENTS 157
NITTA GELATIN INC. 158
NORDZUCKER AG 158
NOVOZYMES A/S 159
NUSIL TECHNOLOGY LLC 159
OMYA 160
PERRIGO CO. PLC. 160
PandG CHEMICALS 161
R.T. VANDERBILT CO. INC. 161
ROQUETTE FRERES 162
ROUSSELOT S.A.S. 163
SASOL LTD. ADR 163
SENSIENT TECHNOLOGIES CORP. 163
SEPPIC S.A. 164
SHIN-ETSU CHEMICAL CO. LTD. 164
SOLVAY S.A. 165
SPI PHARMA INC. 166
STEPAN SPECIALTY PRODUCTS LLC. 166
USG CORP. 166
W.R. GRACE and CO. 167
WEISHARDT GROUP 167

LIST OF TABLES

SUMMARY TABLE GLOBAL EXCIPIENT MARKET BY MATERIAL TYPE, THROUGH 2020
($ MILLIONS) 7
TABLE 1 CHARACTERISTICS CONSIDERED FOR EXCIPIENT SELECTION 11
TABLE 2 CHARACTERISTICS OF AN IDEAL EXCIPIENT 12
TABLE 3 TYPES OF PHYSICAL INTERACTIONS 13
TABLE 4 TYPES OF CHEMICAL INTERACTIONS 14
TABLE 5 PACKAGE-EXCIPIENT INTERACTIONS 17
TABLE 6 SOME EXCIPIENTS AND THEIR THERAPEUTIC FUNCTIONS 20
TABLE 7 NEW PRODUCTS LAUNCHED, 2014 AND 2015 36
TABLE 8 MERGERS AND ACQUISITIONS, 2014-2015 38
TABLE 9 GLOBAL EXCIPIENT MARKET BY MATERIAL TYPE, THROUGH 2020 ($
MILLIONS) 44
TABLE 10 GLOBAL ORGANIC CHEMICAL EXCIPIENT MARKET BY MATERIAL TYPE,
THROUGH 2020 ($ MILLIONS) 47
TABLE 11 GLOBAL CARBOHYDRATE EXCIPIENT MARKET BY TYPE, THROUGH 2020 ($
MILLIONS) 48
TABLE 12 GLOBAL CELLULOSE EXCIPIENT MARKET BY TYPE, THROUGH 2020 ($
MILLIONS) 51
TABLE 13 GLOBAL SUGAR EXCIPIENT MARKET BY TYPE, THROUGH 2020 ($ MILLIONS) 52
TABLE 14 GLOBAL ACTUAL SUGARS EXCIPIENT MARKET BY TYPE, THROUGH 2020 ($
MILLIONS) 54
TABLE 15 GLOBAL SUGAR ALCOHOL (POLYOL) EXCIPIENT MARKET BY TYPE,
THROUGH 2020 ($ MILLIONS) 55
TABLE 16 GLOBAL ARTIFICIAL SWEETENER EXCIPIENT MARKET, THROUGH 2020 ($
MILLIONS) 56
TABLE 17 GLOBAL STARCHES EXCIPIENT MARKET BY TYPE, THROUGH 2020 ($
MILLIONS) 59
TABLE 18 GLOBAL PETROCHEMICAL EXCIPIENT MARKET BY TYPE, THROUGH 2020 ($
MILLIONS) 61
TABLE 19 GLOBAL GLYCOL EXCIPIENT MARKET BY TYPE, THROUGH 2020 ($
MILLIONS) 63
TABLE 20 GLOBAL MINERAL HYDROCARBON EXCIPIENT MARKET BY TYPE, THROUGH
2020 ($ MILLIONS) 65
TABLE 21 GLOBAL OLEOCHEMICAL EXCIPIENT MARKET BY TYPE, THROUGH 2020 ($
MILLIONS) 68
TABLE 22 GLOBAL PROTEINS (GELATIN) EXCIPIENT MARKET, THROUGH 2020 ($
MILLIONS) 70
TABLE 23 GLOBAL OTHER ORGANIC CHEMICAL EXCIPIENT MARKET, THROUGH 2020
($ MILLIONS) 72
TABLE 24 GLOBAL INORGANIC CHEMICAL EXCIPIENT MARKET BY TYPE, THROUGH
2020 ($ MILLIONS) 73
TABLE 25 GLOBAL CALCIUM SALTS EXCIPIENT MARKET BY TYPE, THROUGH 2020 ($
MILLIONS) 75
TABLE 26 GLOBAL HALITES MARKET, THROUGH 2020 ($ MILLIONS) 76
TABLE 27 GLOBAL METAL OXIDES EXCIPIENT MARKET BY TYPE, THROUGH 2020 ($
MILLIONS) 78
TABLE 28 GLOBAL SILICATES EXCIPIENT MARKET BY TYPE, THROUGH 2020 ($
MILLIONS) 79
TABLE 29 GLOBAL OTHER INORGANIC EXCIPIENTS MARKET BY TYPE, THROUGH
2020 ($ MILLIONS) 81
TABLE 30 GLOBAL USP WATER EXCIPIENT MARKET BY TYPE, THROUGH 2020 ($
MILLIONS) 83
TABLE 31 GLOBAL EXCIPIENT FUNCTIONAL USES MARKET BY TYPE, THROUGH 2020
($ MILLIONS) 85
TABLE 32 GLOBAL EMOLLIENTS EXCIPIENT MARKET BY MATERIAL, THROUGH 2020
($ MILLIONS) 86
TABLE 33 GLOBAL EXCIPIENT FILLER MARKET BY TYPE, THROUGH 2020 ($ MILLIONS) 88
TABLE 34 GLOBAL VEHICLE EXCIPIENT MARKET BY TYPE, THROUGH 2020 ($
MILLIONS) 89
TABLE 35 GLOBAL COATINGS EXCIPIENT MARKET BY TYPE, THROUGH 2020 ($
MILLIONS) 91
TABLE 36 GLOBAL SUPERDISINTEGRANT EXCIPIENT MARKET BY TYPE, THROUGH
2020 ($ MILLIONS) 93
TABLE 37 GLOBAL FLAVORS EXCIPIENT MARKET BY TYPE, THROUGH 2020 ($
MILLIONS) 94
TABLE 38 GLOBAL COLORANT EXCIPIENT MARKET BY TYPE, THROUGH 2020 ($
MILLIONS) 96
TABLE 39 MAJOR SUPPLIERS OF CARBOHYDRATE EXCIPIENTS, 2015 100
TABLE 40 GLOBAL MARKET SHARE OF MAJOR CARBOHYDRATES SUPPLIERS, 2015 (%) 101
TABLE 41 MAJOR SUPPLIERS OF PETROCHEMICAL EXCIPIENTS, 2015 103
TABLE 42 GLOBAL MARKET SHARE OF MAJOR PETROCHEMICAL SUPPLIERS, 2015 (%) 104
TABLE 43 MAJOR SUPPLIERS OF OLEOCHEMICALS, PROTEINS AND OTHER
EXCIPIENTS, 2015 105
TABLE 44 GLOBAL MARKET SHARE OF MAJOR OLEOCHEMICAL SUPPLIERS, 2015 (%) 106
TABLE 45 GLOBAL MARKET SHARE OF MAJOR PROTEIN SUPPLIERS, 2015 (%) 107
TABLE 46 GLOBAL MARKET SHARE OF MAJOR OTHER ORGANIC EXCIPIENTS
SUPPLIERS, 2015 (%) 108
TABLE 47 MAJOR INORGANIC EXCIPIENT SUPPLIERS, 2015 109
TABLE 48 GLOBAL MARKET SHARE OF MAJOR CALCIUM SALTS SUPPLIERS, 2015 (%) 110
TABLE 49 GLOBAL MARKET SHARE OF MAJOR HALITES SUPPLIERS, 2015 (%) 111
TABLE 50 GLOBAL MARKET SHARE OF MAJOR METAL OXIDES SUPPLIERS, 2015 (%) 112
TABLE 51 GLOBAL MARKET SHARE OF MAJOR SILICATES SUPPLIERS, 2015 (%) 113
TABLE 52 GLOBAL MARKET SHARE OF MAJOR OTHER INORGANIC EXCIPIENTS
SUPPLIERS, 2015 (%) 114
TABLE 53 NUMBER OF PATENTS BY YEAR, 2013-OCTOBER 2015 116
TABLE 54 NUMBER OF PATENTS BY CATEGORY FOR EXCIPIENTS IN THE
PHARMACEUTICAL INDUSTRY, 2013-OCTOBER 2015 117
TABLE 55 NUMBER OF U.S. PATENTS FOR EXCIPIENTS BY COMPANY, 2013-OCTOBER
2015 118
TABLE 56 NUMBER OF U.S. PATENTS BY COUNTRY FOR EXCIPIENTS, 2013-OCTOBER
2015 120
TABLE 57 EXCIPIENT PATENTS BY COUNTRY, 2013-OCTOBER 2015 (NUMBER/%) 121
TABLE 58 NUMBER OF EXCIPIENT PATENTS BY ASSIGNEE, 2013-OCTOBER 2015 122
TABLE 59 LIST OF COMPANIES WITH EXCIPACT CERTIFICATES 129

LIST OF FIGURES

SUMMARY FIGURE GLOBAL EXCIPIENT MARKET BY MATERIAL TYPE, 2013-2020 ($
MILLIONS) 7
FIGURE 1 GLOBAL EXCIPIENT MARKET BY MATERIAL TYPE, 2013-2020 ($ MILLIONS) 45
FIGURE 2 GLOBAL ORGANIC CHEMICAL EXCIPIENT MARKET BY MATERIAL TYPE,
2013-2020 ($ MILLIONS) 47
FIGURE 3 GLOBAL CARBOHYDRATE EXCIPIENT MARKET BY TYPE, 2013-2020 ($
MILLIONS) 48
FIGURE 4 GLOBAL CELLULOSE EXCIPIENT MARKET BY TYPE, 2013-2020 ($ MILLIONS) 51
FIGURE 5 GLOBAL SUGAR EXCIPIENT MARKET BY TYPE, 2013-2020 ($ MILLIONS) 52
FIGURE 6 GLOBAL ACTUAL SUGAR EXCIPIENT MARKET BY TYPE, 2013-2020 ($
MILLIONS) 54
FIGURE 7 GLOBAL SUGAR ALCOHOL (POLYOL) EXCIPIENT MARKET BY TYPE,
2013-2020 ($ MILLIONS) 55
FIGURE 8 GLOBAL ARTIFICIAL SWEETENER EXCIPIENT MARKET, 2013-2020 ($
MILLIONS) 56
FIGURE 9 GLOBAL STARCHES EXCIPIENT MARKET BY TYPE, 2013-2020 ($ MILLIONS) 59
FIGURE 10 GLOBAL PETROCHEMICAL EXCIPIENT MARKET BY TYPE, 2013-2020 ($
MILLIONS) 61
FIGURE 11 GLOBAL GLYCOL EXCIPIENT MARKET BY TYPE, 2013-2020 ($ MILLIONS) 63
FIGURE 12 GLOBAL MINERAL HYDROCARBON EXCIPIENT MARKET BY TYPE,
2013-2020 ($ MILLIONS) 65
FIGURE 13 GLOBAL OLEOCHEMICAL EXCIPIENT MARKET BY TYPE, 2013-2020 ($
MILLIONS) 68
FIGURE 14 GLOBAL PROTEINS (GELATIN) EXCIPIENT MARKET, 2013-2020 ($
MILLIONS) 70
FIGURE 15 GLOBAL OTHER ORGANIC CHEMICAL EXCIPIENT MARKET, 2013-2020 ($
MILLIONS) 72
FIGURE 16 GLOBAL INORGANIC CHEMICAL EXCIPIENT MARKET BY TYPE, 2013-2020
($ MILLIONS) 73
FIGURE 17 GLOBAL CALCIUM SALTS EXCIPIENT MARKET BY TYPE, 2013-2020 ($
MILLIONS) 75
FIGURE 18 GLOBAL HALITE MARKET, 2013-2020 ($ MILLIONS) 76
FIGURE 19 GLOBAL METAL OXIDES EXCIPIENT MARKET BY TYPE, 2013-2020 ($
MILLIONS) 78
FIGURE 20 GLOBAL SILICATES EXCIPIENT MARKET BY TYPE, 2013-2020 ($ MILLIONS) 79
FIGURE 21 GLOBAL OTHER INORGANIC EXCIPIENTS MARKET BY TYPE, 2013-2020 ($
MILLIONS) 81
FIGURE 22 GLOBAL USP WATER EXCIPIENT MARKET BY TYPE, 2013-2020 ($
MILLIONS) 83
FIGURE 23 GLOBAL EXCIPIENT FUNCTIONAL USES MARKET BY TYPE, 2013-2020 ($
MILLIONS) 85
FIGURE 24 GLOBAL EMOLLIENTS EXCIPIENT MARKET BY MATERIAL, 2013-2020 ($
MILLIONS) 86
FIGURE 25 GLOBAL EXCIPIENT FILLER MARKET BY TYPE, 2013-2020 ($ MILLIONS) 88
FIGURE 26 GLOBAL VEHICLE EXCIPIENT MARKET BY TYPE, 2013-2020 ($ MILLIONS) 89
FIGURE 27 GLOBAL COATINGS EXCIPIENT MARKET BY TYPE, 2013-2020 ($ MILLIONS) 91
FIGURE 28 GLOBAL SUPERDISINTEGRANT EXCIPIENT MARKET BY TYPE, 2013-2020
($ MILLIONS) 93
FIGURE 29 GLOBAL FLAVORS EXCIPIENT MARKET BY TYPE, 2013-2020 ($ MILLIONS) 94
FIGURE 30 GLOBAL COLORANT EXCIPIENT MARKET BY TYPE, 2013-2020 ($ MILLIONS) 96
FIGURE 31 GLOBAL MARKET SHARE OF MAJOR CARBOHYDRATES SUPPLIERS, 2015
(%) 102
FIGURE 32 GLOBAL MARKET SHARE OF MAJOR PETROCHEMICAL SUPPLIERS, 2015
(%) 104
FIGURE 33 GLOBAL MARKET SHARE OF MAJOR OLEOCHEMICAL SUPPLIERS, 2015 (%) 106
FIGURE 34 GLOBAL MARKET SHARE OF MAJOR PROTEIN SUPPLIERS, 2015 (%) 107
FIGURE 35 GLOBAL MARKET SHARE OF MAJOR OTHER ORGANIC EXCIPIENTS
SUPPLIERS, 2015 (%) 108
FIGURE 36 GLOBAL MARKET SHARE OF MAJOR CALCIUM SALTS SUPPLIERS, 2015 (%) 110
FIGURE 37 GLOBAL MARKET SHARE OF MAJOR HALITES SUPPLIERS, 2015 (%) 111
FIGURE 38 GLOBAL MARKET SHARE OF MAJOR METAL OXIDES SUPPLIERS, 2015 (%) 112
FIGURE 39 GLOBAL MARKET SHARE OF MAJOR SILICATES SUPPLIERS, 2015 (%) 113
FIGURE 40 GLOBAL MARKET SHARE OF MAJOR OTHER INORGANIC EXCIPIENTS
SUPPLIERS, 2015 (%) 114
FIGURE 41 NUMBER OF PATENTS BY YEAR, 2013-OCTOBER 2015 117
FIGURE 42 NUMBER OF PATENTS BY CATEGORY FOR EXCIPIENTS IN THE
PHARMACEUTICAL INDUSTRY, 2013-OCTOBER 2015 117
FIGURE 43 NUMBER OF EXCIPIENT PATENTS BY ASSIGNEE, 2013-OCTOBER 2015 122

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